Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF527	84503	broad.mit.edu	37	19	37880337	37880337	+	Missense_Mutation	SNP	A	A	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr19:37880337A>T	ENST00000436120.2	+	5	1493	c.1386A>T	c.(1384-1386)agA>agT	p.R462S	ZNF527_ENST00000587349.1_Intron	NM_032453.1	NP_115829.1	Q8NB42	ZN527_HUMAN	zinc finger protein 527	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	33			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AACATCAGAGAATTCATACCG	0.403000													4	63					0	0	1	0	0
EBNA1BP2	10969	broad.mit.edu	37	1	43630368	43630368	+	Silent	SNP	C	C	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:43630368C>A	ENST00000431635.2	-	9	1129	c.981G>T	c.(979-981)cgG>cgT	p.R327R	EBNA1BP2_ENST00000236051.2_Silent_p.R272R	NM_001159936.1	NP_001153408.1	Q99848	EBP2_HUMAN	EBNA1 binding protein 2	272					ribosome biogenesis	membrane fraction|nucleolus	protein binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)	16	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTGTCTTGGCCCGGAAGCTAG	0.527000													11	55					5.16669e-11	7.33959e-11	1	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144882638	144882638	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:144882638G>C	ENST00000369359.4	-	27	3830	c.3792C>G	c.(3790-3792)agC>agG	p.S1264R	PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.S1264R|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.S1127R|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.S1127R|PDE4DIP_ENST00000313382.9_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1127					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCCCTTCCTTGCTACTCAGCA	0.468000			T	PDGFRB	MPD								19	224					0	0	1	0	0
MYRF	745	broad.mit.edu	37	11	61549225	61549225	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr11:61549225G>A	ENST00000278836.5	+	22	3041	c.2945G>A	c.(2944-2946)gGc>gAc	p.G982D	MYRF_ENST00000389602.4_Missense_Mutation_p.G373D|MYRF_ENST00000265460.5_Missense_Mutation_p.G947D|TMEM258_ENST00000535042.1_Intron	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		GGTTTCCATGGCCGGGCCCGC	0.672000													10	37					0	0	1	0	0
TSPAN11	441631	broad.mit.edu	37	12	31132592	31132592	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr12:31132592G>A	ENST00000261177.9	+	5	502	c.443G>A	c.(442-444)cGa>cAa	p.R148Q	TSPAN11_ENST00000546076.1_Missense_Mutation_p.R148Q|TSPAN11_ENST00000535215.1_Missense_Mutation_p.R77Q|TSPAN11_ENST00000544427.1_Missense_Mutation_p.R138Q	NM_001080509.2	NP_001073978.1	A1L157	TSN11_HUMAN	tetraspanin 11	148						integral to membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)	11	all_lung(12;3.11e-10)|Lung NSC(12;5.24e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					TCAGTGGACCGACTCCAGCAG	0.572000													3	32					0	0	1	0	0
ZNF354A	6940	broad.mit.edu	37	5	178139986	178139986	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr5:178139986T>C	ENST00000335815.2	-	5	1090	c.893A>G	c.(892-894)tAc>tGc	p.Y298C		NM_005649.2	NP_005640.2	O60765	Z354A_HUMAN	zinc finger protein 354A	298					regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(7)|lung(3)|ovary(2)|skin(2)|stomach(2)	19	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		TTTACATCTGTAGGATTTCTC	0.383000													11	57					0	0	1	0	0
ZNF704	619279	broad.mit.edu	37	8	81577153	81577153	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr8:81577153C>A	ENST00000327835.3	-	6	1055	c.824G>T	c.(823-825)cGa>cTa	p.R275L		NM_001033723.2	NP_001028895.1	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	275						intracellular	zinc ion binding			lung(9)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			AGTTTCTGTTCGGCTTGAATC	0.577000													8	77					1.12685e-05	1.43934e-05	1	1	0
SH3BP5	9467	broad.mit.edu	37	3	15311359	15311359	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr3:15311359G>A	ENST00000383791.3	-	4	576	c.356C>T	c.(355-357)aCg>aTg	p.T119M	SH3BP5_ENST00000465894.2_5'UTR|SH3BP5_ENST00000408919.3_De_novo_Start_InFrame|SH3BP5_ENST00000426925.1_De_novo_Start_InFrame|SH3BP5_ENST00000253688.5_De_novo_Start_InFrame	NM_004844.4	NP_004835.2	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	119					intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding			NS(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	12						GAAGTCCTGCGTGGCTTTCTG	0.577000													5	95					0	0	1	0	0
ZNF706	51123	broad.mit.edu	37	8	102213947	102213947	+	Missense_Mutation	SNP	A	A	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr8:102213947A>T	ENST00000520347.1	-	2	2979	c.23T>A	c.(22-24)aTt>aAt	p.I8N	ZNF706_ENST00000517844.1_Missense_Mutation_p.I8N|ZNF706_ENST00000311212.4_Missense_Mutation_p.I8N|ZNF706_ENST00000519744.1_Missense_Mutation_p.I8N|ZNF706_ENST00000518336.1_Missense_Mutation_p.I8N|ZNF706_ENST00000519882.1_Missense_Mutation_p.I8N|ZNF706_ENST00000520984.1_Missense_Mutation_p.I8N|ZNF706_ENST00000521272.1_Missense_Mutation_p.I8N			Q9Y5V0	ZN706_HUMAN	zinc finger protein 706	8						intracellular	zinc ion binding			large_intestine(1)|ovary(2)	3	all_cancers(14;3.3e-07)|all_epithelial(15;3.47e-09)|Lung NSC(17;3.44e-05)|all_lung(17;0.000117)		Epithelial(11;8.57e-11)|all cancers(13;1.43e-08)|OV - Ovarian serous cystadenocarcinoma(57;1.43e-05)			CTGAGACTGAATTTTCTGCTG	0.393000													10	37					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													4	62					0	0	1	0	0
RGS5	8490	broad.mit.edu	37	1	163117184	163117184	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:163117184T>C	ENST00000313961.5	-	5	771	c.494A>G	c.(493-495)gAt>gGt	p.D165G	RGS5_ENST00000527988.1_Missense_Mutation_p.D57G|RGS5_ENST00000530507.1_Missense_Mutation_p.D169G|RGS5_ENST00000367903.3_Missense_Mutation_p.D185G	NM_001254749.1|NM_003617.3	NP_001241678.1|NP_003608.1	O15539	RGS5_HUMAN	regulator of G-protein signaling 5	165	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(1)|lung(12)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20			LUSC - Lung squamous cell carcinoma(543;0.187)			AGGCAGAGAATCCTTTTCCAT	0.443000													16	54					0	0	1	0	0
OR14I1	401994	broad.mit.edu	37	1	248845027	248845027	+	Silent	SNP	T	T	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:248845027T>C	ENST00000342623.3	-	1	602	c.579A>G	c.(577-579)gtA>gtG	p.V193V		NM_001004734.1	NP_001004734.1	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I, member 1	193					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(4)|large_intestine(2)|lung(24)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	35						TCAAAAACTCTACAAAGAAAA	0.478000													19	43					0	0	1	0	0
CLMN	79789	broad.mit.edu	37	14	95688095	95688095	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr14:95688095G>T	ENST00000298912.4	-	4	370	c.257C>A	c.(256-258)tCc>tAc	p.S86Y		NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	86	Actin-binding.|CH 1.					integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		ATGCGACGAGGATTTGTATTC	0.438000													3	27					0.004672	0.00510895	1	1	0
LHCGR	3973	broad.mit.edu	37	2	48915911	48915911	+	Missense_Mutation	SNP	C	C	A	rs149957775		TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr2:48915911C>A	ENST00000294954.7	-	11	1046	c.1025G>T	c.(1024-1026)cGa>cTa	p.R342L	LHCGR_ENST00000405626.1_Missense_Mutation_p.R315L|LHCGR_ENST00000403273.1_Intron|LHCGR_ENST00000401907.1_Intron|LHCGR_ENST00000344775.3_Missense_Mutation_p.R280L|STON1-GTF2A1L_ENST00000402114.2_Intron	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	342					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	AGGAGCACATCGGGGTGTCTT	0.428000													15	110					3.52763e-06	4.62241e-06	1	1	0
MAX	4149	broad.mit.edu	37	14	65544713	65544713	+	Silent	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr14:65544713G>A	ENST00000284165.6	-	4	361	c.213C>T	c.(211-213)atC>atT	p.I71I	MAX_ENST00000358402.4_Silent_p.I62I|MAX_ENST00000358664.4_Silent_p.I71I|MAX_ENST00000341653.2_Intron|MAX_ENST00000557746.1_Silent_p.I62I|MAX_ENST00000557277.1_5'UTR|MAX_ENST00000556979.1_Silent_p.I71I|MAX_ENST00000556443.1_Silent_p.I62I|MAX_ENST00000555932.1_Intron|MAX_ENST00000555667.1_Silent_p.I62I|MAX_ENST00000555419.1_Silent_p.I35I	NM_145113.1	NP_660088.1	P61244	MAX_HUMAN	MYC associated factor X	71	Helix-loop-helix motif.				transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	17				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		GCATATACTGGATATATTCTG	0.493000													7	35					0	0	1	0	0
TNFRSF10A	8797	broad.mit.edu	37	8	23054712	23054712	+	Silent	SNP	C	C	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr8:23054712C>A	ENST00000221132.3	-	9	1084	c.1020G>T	c.(1018-1020)ccG>ccT	p.P340P		NM_003844.3	NP_003835.3	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily, member 10a	340					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			NS(2)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|skin(1)	16		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		CAGCTTCTGCCGGTCCCTGTA	0.562000													7	85					8.12818e-05	9.5774e-05	1	1	0
GPRC5B	51704	broad.mit.edu	37	16	19884024	19884024	+	Silent	SNP	C	C	G			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr16:19884024C>G	ENST00000300571.2	-	2	335	c.144G>C	c.(142-144)ctG>ctC	p.L48L	GPRC5B_ENST00000569847.1_Silent_p.L48L|GPRC5B_ENST00000535671.1_Silent_p.L48L|GPRC5B_ENST00000569479.1_Silent_p.L48L|GPRC5B_ENST00000537135.1_Silent_p.L74L	NM_016235.1	NP_057319.1	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5, member B	48										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						CCAGGTCGCACAGGGACACGT	0.652000													10	45					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225750440	225750440	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr2:225750440G>A	ENST00000409592.3	-	7	790	c.677C>T	c.(676-678)tCc>tTc	p.S226F	DOCK10_ENST00000258390.7_Missense_Mutation_p.S232F			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	232	PH.						GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		GGGTTCTTTGGATATTTTCTC	0.363000													5	21					0	0	1	0	0
WHAMMP3	339005	broad.mit.edu	37	15	23191911	23191911	+	RNA	SNP	C	C	T	rs147199465	by1000genomes	TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr15:23191911C>T	ENST00000400153.2	-	0	1785					NR_003521.1																						TGATTTTCTTCGCACTGATCC	0.408000													4	33					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22941413	22941413	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr19:22941413G>T	ENST00000397104.3	-	5	1024	c.1025C>A	c.(1024-1026)gCt>gAt	p.A342D	ZNF99_ENST00000596209.1_Missense_Mutation_p.A433D					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ACGCTTAAAAGCTTTGCCACA	0.363000													5	31					0.000602214	0.000673063	1	1	0
ZACN	353174	broad.mit.edu	37	17	74077707	74077707	+	Missense_Mutation	SNP	G	G	A	rs146722649		TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr17:74077707G>A	ENST00000334586.5	+	7	834	c.751G>A	c.(751-753)Ggg>Agg	p.G251R	EXOC7_ENST00000589210.1_3'UTR|EXOC7_ENST00000591724.1_Intron|EXOC7_ENST00000607838.1_3'UTR|EXOC7_ENST00000332065.5_3'UTR	NM_180990.3	NP_851321.2	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	251	Leu-rich.				response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	11						TGACGTGTGCGGGGGGTTGCT	0.612000													10	129					0	0	1	0	0
FCHO1	23149	broad.mit.edu	37	19	17883286	17883286	+	Silent	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr19:17883286G>A	ENST00000594202.1	+	10	894	c.615G>A	c.(613-615)gaG>gaA	p.E205E	FCHO1_ENST00000596951.1_Silent_p.E205E|FCHO1_ENST00000596536.1_Silent_p.E205E|FCHO1_ENST00000252771.7_Silent_p.E205E|FCHO1_ENST00000539407.1_Silent_p.E205E|FCHO1_ENST00000389133.4_Silent_p.E205E|FCHO1_ENST00000595033.1_Silent_p.E155E|FCHO1_ENST00000597512.1_Silent_p.E212E|FCHO1_ENST00000600676.1_Silent_p.E205E	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	205										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						CCATGGAGGAGACACACCTGA	0.582000													4	32					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	102991263	102991263	+	Nonsense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr11:102991263G>T	ENST00000375735.2	+	7	1231	c.1087G>T	c.(1087-1089)Gaa>Taa	p.E363*	DYNC2H1_ENST00000334267.7_Nonsense_Mutation_p.E363*|DYNC2H1_ENST00000398093.3_Nonsense_Mutation_p.E363*	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	363	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TCGAGTATTTGAACCTTTTAC	0.338000													25	142					4.72057e-08	6.2941e-08	1	1	0
HSF5	124535	broad.mit.edu	37	17	56536222	56536222	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr17:56536222C>T	ENST00000323777.3	-	5	1736	c.1627G>A	c.(1627-1629)Ggg>Agg	p.G543R		NM_001080439.1	NP_001073908.1	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	543						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	16	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTAGCAGGCCCCATTTCTGAA	0.468000													10	143					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													6	34					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10300161	10300161	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr17:10300161C>T	ENST00000403437.2	-	31	4415	c.4321G>A	c.(4321-4323)Gcc>Acc	p.A1441T	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1441					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						GCTGCACAGGCTGCATTAGAC	0.468000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				8	51					0	0	1	0	0
TOP3A	7156	broad.mit.edu	37	17	18205695	18205695	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr17:18205695C>T	ENST00000321105.5	-	7	911	c.697G>A	c.(697-699)Gtg>Atg	p.V233M	TOP3A_ENST00000542570.1_Missense_Mutation_p.V138M	NM_004618.3	NP_004609.1	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	233					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(2)|urinary_tract(1)	36						TCTGCCAGCACCTCAGGAAAA	0.512000													3	27					0	0	1	0	0
ZNF727	442319	broad.mit.edu	37	7	63529299	63529299	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr7:63529299G>C	ENST00000550760.3	+	2	213	c.34G>C	c.(34-36)Gaa>Caa	p.E12Q	RP11-3N2.13_ENST00000445978.1_RNA	NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	12	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						TGTGGCTGTAGAATTCTCCCC	0.423000													3	13					0	0	1	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106070416	106070416	+	Missense_Mutation	SNP	A	A	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chrX:106070416A>C	ENST00000357242.5	+	7	1226	c.1052A>C	c.(1051-1053)aAg>aCg	p.K351T	TBC1D8B_ENST00000276175.3_Missense_Mutation_p.K351T|TBC1D8B_ENST00000310452.2_Missense_Mutation_p.K351T|TBC1D8B_ENST00000481617.2_Missense_Mutation_p.K351T	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	351	GRAM 2.					intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GCTATAGATAAGACAAATGAT	0.348000													16	170					0	0	1	0	0
CROT	54677	broad.mit.edu	37	7	87022300	87022300	+	Silent	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr7:87022300G>T	ENST00000331536.3	+	17	1820	c.1635G>T	c.(1633-1635)ctG>ctT	p.L545L	CROT_ENST00000442291.1_Silent_p.L545L|CROT_ENST00000419147.2_Silent_p.L573L	NM_021151.3	NP_066974.2	Q9UKG9	OCTC_HUMAN	carnitine O-octanoyltransferase	545					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	CAACAAGTCTGGTTGGCTATT	0.408000													21	126					4.35082e-09	6.01204e-09	1	1	0
OR4S2	219431	broad.mit.edu	37	11	55418445	55418445	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr11:55418445G>T	ENST00000312422.2	+	1	66	c.66G>T	c.(64-66)gaG>gaT	p.E22D		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	22					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				CAGAGATTGAGAAAGTTTGTT	0.373000													4	65					0.150653	0.154725	1	1	0
CPD	1362	broad.mit.edu	37	17	28776584	28776584	+	Missense_Mutation	SNP	A	A	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr17:28776584A>T	ENST00000225719.4	+	13	2963	c.2887A>T	c.(2887-2889)Act>Tct	p.T963S	CPD_ENST00000543464.2_Missense_Mutation_p.T716S	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	963	Carboxypeptidase-like 3.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						GGGACAGAGCACTGAATATCG	0.353000													12	91					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28968923	28968923	+	Silent	SNP	C	C	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr18:28968923C>T	ENST00000359747.4	+	5	488	c.459C>T	c.(457-459)aaC>aaT	p.N153N	RP11-534N16.1_ENST00000581856.1_RNA|DSG4_ENST00000308128.4_Silent_p.N153N|RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	153	Cadherin 1.		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TAAATGATAACGCTCCAGTCT	0.413000													27	71					0	0	1	0	0
IGKV1D-16	28901	broad.mit.edu	37	2	90139426	90139426	+	RNA	SNP	C	C	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr2:90139426C>A	ENST00000492446.1	+	0	224																											GAGAAAGCCCCTAAGTCCCTG	0.527000													21	188					2.37509e-13	3.50499e-13	1	1	0
RRP12	23223	broad.mit.edu	37	10	99161040	99161040	+	Translation_Start_Site	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr10:99161040G>A	ENST00000370992.4	-	0	60				RP11-452K12.7_ENST00000422848.1_RNA|RRP12_ENST00000315563.6_5'UTR|RRP12_ENST00000414986.1_De_novo_Start_OutOfFrame	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)							integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		TTCCAGGGACGTAGAAACACG	0.512000													3	25					0	0	1	0	0
SNTG1	54212	broad.mit.edu	37	8	51442786	51442786	+	Silent	SNP	T	T	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr8:51442786T>C	ENST00000522124.1	+	10	1177	c.516T>C	c.(514-516)agT>agC	p.S172S	SNTG1_ENST00000517473.1_Silent_p.S172S|SNTG1_ENST00000518864.1_Silent_p.S172S|SNTG1_ENST00000276467.5_Silent_p.S172S	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	172					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TCTGTGACAGTGGCTTACATC	0.448000													6	65					0	0	1	0	0
TUBGCP3	10426	broad.mit.edu	37	13	113200110	113200110	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr13:113200110G>C	ENST00000261965.3	-	11	1424	c.1238C>G	c.(1237-1239)tCt>tGt	p.S413C	TUBGCP3_ENST00000375669.3_Missense_Mutation_p.S413C|TUBGCP3_ENST00000462580.1_5'UTR	NM_006322.4	NP_006313.1	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	413					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|urinary_tract(1)	25	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					CTGCACCAGAGACCGCATGTA	0.512000													8	95					0	0	1	0	0
FAM26F	441168	broad.mit.edu	37	6	116784525	116784525	+	Missense_Mutation	SNP	T	T	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr6:116784525T>A	ENST00000368605.1	+	3	700	c.605T>A	c.(604-606)gTt>gAt	p.V202D	RP1-93H18.6_ENST00000476099.1_RNA|FAM26F_ENST00000368606.3_Missense_Mutation_p.V30D	NM_001010919.1	NP_001010919.1	Q5R3K3	FA26F_HUMAN	family with sequence similarity 26, member F	202						integral to membrane				large_intestine(2)|lung(1)	3				GBM - Glioblastoma multiforme(226;0.0402)|all cancers(137;0.0627)|OV - Ovarian serous cystadenocarcinoma(136;0.0655)|Epithelial(106;0.231)		CTATCTCCAGTTAGTTTTCTG	0.393000													15	94					0	0	1	0	0
CXCL6	6372	broad.mit.edu	37	4	74702522	74702522	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr4:74702522T>C	ENST00000226317.5	+	1	309	c.55T>C	c.(55-57)Tgc>Cgc	p.C19R	CXCL6_ENST00000515050.1_Missense_Mutation_p.C19R	NM_002993.3	NP_002984.1	P80162	CXCL6_HUMAN	chemokine (C-X-C motif) ligand 6	19					cell-cell signaling|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding			large_intestine(1)|lung(7)	8	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			GGGCTCCTTGTGCGCGCTGCT	0.731000													3	8					0	0	1	0	0
SLC35D1	23169	broad.mit.edu	37	1	67517708	67517708	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:67517708T>C	ENST00000235345.5	-	4	464	c.379A>G	c.(379-381)Aca>Gca	p.T127A	SLC35D1_ENST00000506472.2_Missense_Mutation_p.T48A	NM_015139.2	NP_055954.1	Q9NTN3	S35D1_HUMAN	solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1	127					chondroitin sulfate biosynthetic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	integral to endoplasmic reticulum membrane	UDP-glucuronic acid transmembrane transporter activity|UDP-N-acetylgalactosamine transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(4)	10					Lorazepam(DB00186)	AGTTTCTTTGTGCTGAACAGT	0.289000													5	61					0	0	1	0	0
GLUL	2752	broad.mit.edu	37	1	182354917	182354917	+	Missense_Mutation	SNP	T	T	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:182354917T>A	ENST00000311223.5	-	6	1477	c.581A>T	c.(580-582)aAt>aTt	p.N194I	GLUL_ENST00000491322.1_5'UTR|GLUL_ENST00000417584.2_Missense_Mutation_p.N194I|GLUL_ENST00000331872.6_Missense_Mutation_p.N194I|GLUL_ENST00000339526.4_Missense_Mutation_p.N194I	NM_002065.5	NP_002056.2	P15104	GLNA_HUMAN	glutamate-ammonia ligase	194					cell proliferation|glutamine biosynthetic process|neurotransmitter uptake	cytosol|Golgi apparatus|mitochondrion	ATP binding|glutamate decarboxylase activity|glutamate-ammonia ligase activity|identical protein binding			endometrium(2)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(1)	16					Asparaginase(DB00023)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)|L-Methionine(DB00134)	GACCTCGGCATTAGTCCCCGC	0.517000													46	286					0	0	1	0	0
GALNT12	79695	broad.mit.edu	37	9	101585613	101585613	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr9:101585613G>T	ENST00000375011.3	+	2	447	c.447G>T	c.(445-447)tgG>tgT	p.W149C		NM_024642.4	NP_078918.3	Q8IXK2	GLT12_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	149	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)|endometrium(2)|large_intestine(3)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(62;0.0559)				ATGAAGCCTGGTCAACTCTCC	0.418000													4	66					0.00024832	0.000290343	1	1	0
CDH7	1005	broad.mit.edu	37	18	63547761	63547761	+	Silent	SNP	G	G	T	rs142025693		TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr18:63547761G>T	ENST00000397968.2	+	12	2415	c.1989G>T	c.(1987-1989)acG>acT	p.T663T	CDH7_ENST00000323011.3_Silent_p.T663T	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	663					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				AGGAGGACACGGAAGCGTTTG	0.493000													16	44					4.14922e-12	6.00649e-12	1	1	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587518	43587518	+	RNA	SNP	C	C	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr17:43587518C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tgccgtgagccgagatcgcgt	0.498000													8	10					0	0	1	0	0
HAPLN1	1404	broad.mit.edu	37	5	82940364	82940364	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr5:82940364C>A	ENST00000274341.4	-	4	1443	c.593G>T	c.(592-594)tGg>tTg	p.W198L		NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	198	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		CCCGCCCCGCCAGGCGTCGTA	0.617000													10	42					3.86212e-05	4.7727e-05	1	1	0
PZP	5858	broad.mit.edu	37	12	9313709	9313709	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr12:9313709G>T	ENST00000261336.2	-	23	2820	c.2792C>A	c.(2791-2793)gCt>gAt	p.A931D	PZP_ENST00000539983.1_5'UTR|PZP_ENST00000381997.2_Missense_Mutation_p.A717D	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						AGACACATTAGCACCTTTAGA	0.418000													8	55					0.000274275	0.000315832	1	1	0
EYS	346007	broad.mit.edu	37	6	66205197	66205197	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr6:66205197G>A	ENST00000503581.1	-	4	644	c.107C>T	c.(106-108)cCc>cTc	p.P36L	EYS_ENST00000393380.2_Missense_Mutation_p.P36L|EYS_ENST00000342421.5_Missense_Mutation_p.P36L|EYS_ENST00000370616.2_Missense_Mutation_p.P36L|EYS_ENST00000370618.3_Missense_Mutation_p.P36L|EYS_ENST00000370621.3_Missense_Mutation_p.P36L	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	36					response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						ATATGATGAGGGTTGTGGATG	0.388000													16	101					0	0	1	0	0
LOC100505782	100505782	broad.mit.edu	37	17	39580816	39580816	+	RNA	SNP	G	G	C	rs72485487	by1000genomes	TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr17:39580816G>C	ENST00000432258.1	+	0	3405																											AGATCAGCTGGGAAGGCTGAG	0.587000													3	37					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14336661	14336661	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr5:14336661C>T	ENST00000344204.4	+	11	1895	c.1871C>T	c.(1870-1872)gCg>gTg	p.A624V	TRIO_ENST00000509967.2_Missense_Mutation_p.A575V|TRIO_ENST00000537187.1_Missense_Mutation_p.A624V	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	624					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					TACACCAATGCGGATAAATTA	0.488000													4	52					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241710412	241710412	+	Silent	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr2:241710412G>A	ENST00000498729.2	-	15	1563	c.1317C>T	c.(1315-1317)agC>agT	p.S439S	KIF1A_ENST00000320389.7_Silent_p.S430S	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	430					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TGGCCTCCTCGCTGCCCGGGG	0.652000													3	40					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48655562	48655562	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr17:48655562C>G	ENST00000352832.5	+	9	2310	c.1938C>G	c.(1936-1938)agC>agG	p.S646R	CACNA1G_ENST00000507896.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000507510.2_Missense_Mutation_p.S646R|CACNA1G_ENST00000515765.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000514181.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000510115.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000510366.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000507609.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000514717.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000513689.2_Missense_Mutation_p.S646R|CACNA1G_ENST00000507336.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000513964.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000512389.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000503485.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000515411.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000505165.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000502264.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000442258.2_Missense_Mutation_p.S646R|CACNA1G_ENST00000515165.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000429973.2_Missense_Mutation_p.S646R|CACNA1G_ENST00000416767.4_Missense_Mutation_p.S646R|CACNA1G_ENST00000360761.4_Missense_Mutation_p.S646R|CACNA1G_ENST00000514079.1_Missense_Mutation_p.S646R|CACNA1G_ENST00000359106.5_Missense_Mutation_p.S646R|CACNA1G_ENST00000358244.5_Missense_Mutation_p.S646R|CACNA1G_ENST00000354983.4_Missense_Mutation_p.S646R	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	646					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCTGCCAAAGCTCTTGCAAGA	0.602000													4	48					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30092425	30092425	+	RNA	SNP	C	C	G			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr18:30092425C>G	ENST00000567636.1	+	0	800					NR_003558.1																						TCCCCCTGGTCCACCCCCTCC	0.547000													8	68					0	0	1	0	0
IFNA7	3444	broad.mit.edu	37	9	21201678	21201678	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr9:21201678C>A	ENST00000239347.3	-	1	526	c.487G>T	c.(487-489)Gcc>Tcc	p.A163S		NM_021057.2	NP_066401.2	P01567	IFNA7_HUMAN	interferon, alpha 7	163					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(6)	12				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		ACCTCCCAGGCACAAGGGCTG	0.418000													34	334					2.75727e-19	4.19105e-19	1	1	0
ZMYM3	9203	broad.mit.edu	37	X	70466527	70466527	+	Nonsense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chrX:70466527G>T	ENST00000373998.1	-	14	3027	c.2330C>A	c.(2329-2331)tCa>tAa	p.S777*	ZMYM3_ENST00000373984.3_Nonsense_Mutation_p.S779*|ZMYM3_ENST00000373988.1_Nonsense_Mutation_p.S779*|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000353904.2_Nonsense_Mutation_p.S777*|ZMYM3_ENST00000314425.5_Nonsense_Mutation_p.S777*	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	777					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					CTGGGGTTTTGACTCAGGAGA	0.488000													3	26					0.004672	0.00510895	1	1	0
ZNF543	125919	broad.mit.edu	37	19	57839339	57839339	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr19:57839339A>G	ENST00000321545.4	+	4	854	c.509A>G	c.(508-510)aAa>aGa	p.K170R		NM_213598.3	NP_998763.2	Q08ER8	ZN543_HUMAN	zinc finger protein 543	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(2)|large_intestine(8)|lung(11)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		ATTACACAGAAACAAGTTTCA	0.433000													14	74					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4839054	4839054	+	Silent	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr7:4839054G>A	ENST00000399583.3	-	15	3370	c.3183C>T	c.(3181-3183)gaC>gaT	p.D1061D	RADIL_ENST00000538469.1_Silent_p.D821D|RADIL_ENST00000536091.1_3'UTR	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	1061	PDZ.				cell adhesion|multicellular organismal development|signal transduction		protein binding	p.D1061D(1)		NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CTGTTTCCACGTCGGACTTCG	0.642000													4	51					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33549426	33549426	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr5:33549426G>T	ENST00000504830.1	-	21	4523	c.4188C>A	c.(4186-4188)gaC>gaA	p.D1396E	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.D1311E	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1396	TSP type-1 6.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GGTTCCGGTGGTCCCGGCTGT	0.577000										HNSCC(64;0.19)			10	57					0.000442599	0.000505828	1	1	0
CRYBB2	1415	broad.mit.edu	37	22	25623918	25623918	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr22:25623918C>T	ENST00000398215.2	+	4	443	c.272C>T	c.(271-273)aCg>aTg	p.T91M		NM_000496.2	NP_000487.1	P43320	CRBB2_HUMAN	crystallin, beta B2	91	Beta/gamma crystallin 'Greek key' 2.				response to stimulus|visual perception		structural constituent of eye lens			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)	10						AGCCGAAGGACGGACTCCCTC	0.597000													5	59					0	0	1	0	0
RAB3IP	117177	broad.mit.edu	37	12	70195461	70195461	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr12:70195461C>T	ENST00000550536.1	+	8	1595	c.1138C>T	c.(1138-1140)Cgg>Tgg	p.R380W	RAB3IP_ENST00000483530.2_Missense_Mutation_p.R364W|RAB3IP_ENST00000362025.5_Missense_Mutation_p.R380W|RAB3IP_ENST00000553099.1_Missense_Mutation_p.R158W|RAB3IP_ENST00000325555.9_Missense_Mutation_p.R158W|RAB3IP_ENST00000551641.1_Missense_Mutation_p.R158W|RAB3IP_ENST00000247833.7_Missense_Mutation_p.R364W|RAB3IP_ENST00000550847.1_Missense_Mutation_p.R71W|AC025263.3_ENST00000550437.1_Missense_Mutation_p.R5W	NM_001278402.1|NM_175623.2	NP_001265331.1|NP_783322.1	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein	380					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding	p.R380W(1)		NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			ACAACCTATCCGGTTTGTGAA	0.403000													7	39					0	0	1	0	0
DISP1	84976	broad.mit.edu	37	1	223177897	223177897	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:223177897C>T	ENST00000284476.6	+	8	3322	c.3158C>T	c.(3157-3159)gCc>gTc	p.A1053V		NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)	1053					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		GTAGACTTTGCCGTCCATTAT	0.542000													23	87					0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61941839	61941839	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr20:61941839G>C	ENST00000422202.1	+	10	1459	c.1391G>C	c.(1390-1392)gGc>gCc	p.G464A	COL20A1_ENST00000326996.6_Missense_Mutation_p.G457A|COL20A1_ENST00000435874.1_Missense_Mutation_p.G464A|COL20A1_ENST00000358894.6_Missense_Mutation_p.G457A			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	457	Fibronectin type-III 2.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					GTTGGCGAAGGCCTGCGGGGC	0.692000													3	13					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113518987	113518987	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr8:113518987G>T	ENST00000297405.5	-	29	5072	c.4828C>A	c.(4828-4830)Cat>Aat	p.H1610N	CSMD3_ENST00000352409.3_Missense_Mutation_p.H1610N|CSMD3_ENST00000343508.3_Missense_Mutation_p.H1570N|CSMD3_ENST00000455883.2_Missense_Mutation_p.H1506N	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1610	CUB 9.					integral to membrane|plasma membrane		p.H1610Y(1)|p.H1570Y(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TCTCTGCTATGCGGATATGGA	0.383000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	56					6.40141e-05	7.72234e-05	1	1	0
ARRDC3	57561	broad.mit.edu	37	5	90678629	90678629	+	Splice_Site	SNP	C	C	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr5:90678629C>T	ENST00000265138.3	-	1	547		c.e1+1			NM_020801.2	NP_065852.1	Q96B67	ARRD3_HUMAN	arrestin domain containing 3						signal transduction	cytoplasm	protein binding			breast(2)|endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	18		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		CAAAAACTTACCTCTTTCGTG	0.363000													6	91					0	0	1	0	0
L1CAM	3897	broad.mit.edu	37	X	153138062	153138062	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chrX:153138062C>A	ENST00000370060.1	-	4	371	c.182G>T	c.(181-183)gGc>gTc	p.G61V	L1CAM_ENST00000361699.4_Missense_Mutation_p.G61V|L1CAM_ENST00000543994.1_Missense_Mutation_p.G63V|L1CAM_ENST00000538883.1_Missense_Mutation_p.G63V|L1CAM_ENST00000370055.1_Missense_Mutation_p.G56V|L1CAM_ENST00000370057.3_Missense_Mutation_p.G61V|L1CAM_ENST00000361981.3_Missense_Mutation_p.G56V	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	61	Ig-like C2-type 1.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTCGGGCTTGCCACTGGCCTC	0.597000													5	57					0.217242	0.220139	1	1	0
POLA2	23649	broad.mit.edu	37	11	65063373	65063373	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr11:65063373T>C	ENST00000265465.3	+	17	2090	c.1559T>C	c.(1558-1560)aTt>aCt	p.I520T	POLA2_ENST00000534785.1_Intron|POLA2_ENST00000541089.1_Missense_Mutation_p.I312T	NM_002689.2	NP_002680.2	Q14181	DPOA2_HUMAN	polymerase (DNA directed), alpha 2, accessory subunit	520					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding			endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	11					Dacarbazine(DB00851)	GACATGGCCATTGACTATGAG	0.532000													10	129					0	0	1	0	0
CC2D1A	54862	broad.mit.edu	37	19	14038722	14038722	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr19:14038722G>T	ENST00000318003.7	+	23	2574	c.2333G>T	c.(2332-2334)cGg>cTg	p.R778L	CC2D1A_ENST00000589606.1_Missense_Mutation_p.R778L	NM_017721.4	NP_060191.3	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	778					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	27			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			GATGGTCGCCGGCCCACAGGG	0.617000													15	139					3.27435e-08	4.40444e-08	1	1	0
ITIH6	347365	broad.mit.edu	37	X	54785265	54785265	+	Silent	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chrX:54785265G>T	ENST00000218436.6	-	8	1271	c.1242C>A	c.(1240-1242)gtC>gtA	p.V414V		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	414	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										GCGCCTGACGGACATTGGAGA	0.617000													4	36					0.000602214	0.000673063	1	1	0
EDIL3	10085	broad.mit.edu	37	5	83549983	83549983	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr5:83549983G>T	ENST00000296591.5	-	2	533	c.115C>A	c.(115-117)Cca>Aca	p.P39T	EDIL3_ENST00000380138.3_Missense_Mutation_p.P39T	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	39	EGF-like 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		GCCAATCCTGGCAAACAGATA	0.398000													4	37					0.150653	0.154725	1	1	0
MAX	4149	broad.mit.edu	37	14	65544712	65544712	+	Nonsense_Mutation	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr14:65544712G>A	ENST00000284165.6	-	4	362	c.214C>T	c.(214-216)Cag>Tag	p.Q72*	MAX_ENST00000358402.4_Nonsense_Mutation_p.Q63*|MAX_ENST00000358664.4_Nonsense_Mutation_p.Q72*|MAX_ENST00000341653.2_Intron|MAX_ENST00000557746.1_Nonsense_Mutation_p.Q63*|MAX_ENST00000557277.1_5'UTR|MAX_ENST00000556979.1_Nonsense_Mutation_p.Q72*|MAX_ENST00000556443.1_Nonsense_Mutation_p.Q63*|MAX_ENST00000555932.1_Intron|MAX_ENST00000555667.1_Nonsense_Mutation_p.Q63*|MAX_ENST00000555419.1_Nonsense_Mutation_p.Q36*	NM_145113.1	NP_660088.1	P61244	MAX_HUMAN	MYC associated factor X	72	Helix-loop-helix motif.				transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	17				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		CGCATATACTGGATATATTCT	0.493000													7	34					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152329055	152329055	+	Missense_Mutation	SNP	G	G	T	rs145274102		TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:152329055G>T	ENST00000388718.5	-	3	1279	c.1207C>A	c.(1207-1209)Cgc>Agc	p.R403S	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	403	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTTGAAAAGCGGCCACAGGAA	0.428000													5	111					1.23904e-05	1.56945e-05	1	1	0
LOC100130331	100130331	broad.mit.edu	37	1	238090615	238090615	+	RNA	SNP	T	T	C	rs2790341	byFrequency	TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:238090615T>C	ENST00000450451.1	+	0	2121					NR_027247.2																						TCAGGGTCACTCACACGGTGC	0.622000													3	29					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113326771	113326771	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr8:113326771G>C	ENST00000297405.5	-	48	7680	c.7436C>G	c.(7435-7437)cCa>cGa	p.P2479R	CSMD3_ENST00000352409.3_Missense_Mutation_p.P2409R|CSMD3_ENST00000343508.3_Missense_Mutation_p.P2439R|CSMD3_ENST00000455883.2_Missense_Mutation_p.P2375R	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2479	CUB 14.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TTGAAGATTTGGGTAACTGTC	0.378000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			9	49					0	0	1	0	0
NFIC	4782	broad.mit.edu	37	19	3449068	3449068	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr19:3449068T>C	ENST00000589123.1	+	7	1108	c.988T>C	c.(988-990)Tcc>Ccc	p.S330P	NFIC_ENST00000341919.3_Missense_Mutation_p.S339P|NFIC_ENST00000586919.1_Missense_Mutation_p.S306P|NFIC_ENST00000395111.3_Missense_Mutation_p.S330P|NFIC_ENST00000346156.5_Missense_Mutation_p.S306P|NFIC_ENST00000443272.2_Missense_Mutation_p.S339P|NFIC_ENST00000590282.1_Missense_Mutation_p.S339P	NM_001245005.1|NM_205843.2	NP_001231934.1|NP_995315.1	P08651	NFIC_HUMAN	nuclear factor I/C (CCAAT-binding transcription factor)	339					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		CAACAGCCCGTCCCCCCAGGA	0.667000													5	24					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255260	140255260	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr5:140255260C>A	ENST00000398631.2	+	1	203	c.203C>A	c.(202-204)tCc>tAc	p.S68Y	PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGGTGGCGTCCAAAAGACAC	0.627000													22	119					3.10358e-05	3.86676e-05	1	1	0
TBX5	6910	broad.mit.edu	37	12	114793760	114793760	+	Nonsense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr12:114793760G>T	ENST00000310346.4	-	9	1800	c.1134C>A	c.(1132-1134)tgC>tgA	p.C378*	TBX5_ENST00000349716.5_Nonsense_Mutation_p.C328*|TBX5_ENST00000405440.2_Nonsense_Mutation_p.C378*	NM_000192.3	NP_000183.2	Q99593	TBX5_HUMAN	T-box 5	378					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(29)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TGGCATACATGCAAGCTTGCC	0.607000													9	59					0.000274275	0.000315832	1	1	0
USH2A	7399	broad.mit.edu	37	1	216262362	216262362	+	Silent	SNP	T	T	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:216262362T>A	ENST00000366943.2	-	23	5264	c.4878A>T	c.(4876-4878)atA>atT	p.I1626I	USH2A_ENST00000307340.3_Silent_p.I1626I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1626	Laminin G-like 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TACCTGTATATATCCCATCCA	0.343000										HNSCC(13;0.011)			14	100					0	0	1	0	0
DAGLA	747	broad.mit.edu	37	11	61504754	61504754	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr11:61504754C>A	ENST00000257215.5	+	14	1588	c.1472C>A	c.(1471-1473)aCc>aAc	p.T491N		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	491					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		CAGTATCCGACCCTCAAGTGC	0.652000													26	183					1.77063e-15	2.66471e-15	1	1	0
LOC101927209	101927209	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													4	61					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769253	31769253	+	Silent	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr19:31769253G>A	ENST00000240587.4	-	2	1773	c.1446C>T	c.(1444-1446)gaC>gaT	p.D482D		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	482					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.D299D(1)|p.D482D(1)		breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					TAGGTTTCTCGTCAGTGACCG	0.478000													31	207					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52526862	52526862	+	Missense_Mutation	SNP	C	C	A	rs139166058	byFrequency	TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr14:52526862C>A	ENST00000216286.5	-	3	746	c.747G>T	c.(745-747)caG>caT	p.Q249H	NID2_ENST00000541773.1_Missense_Mutation_p.Q196H	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	249	NIDO.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					TTTTCACAGACTGTTCAGTGC	0.448000													7	18					1	1	1	1	0
SLC20A2	6575	broad.mit.edu	37	8	42275467	42275467	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr8:42275467C>T	ENST00000342228.3	-	11	2182	c.1813G>A	c.(1813-1815)Gtg>Atg	p.V605M	SLC20A2_ENST00000520262.1_Missense_Mutation_p.V605M|SLC20A2_ENST00000520179.1_Missense_Mutation_p.V605M	NM_006749.4	NP_006740.1	Q08357	S20A2_HUMAN	solute carrier family 20 (phosphate transporter), member 2	605					interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			breast(1)|endometrium(6)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|stomach(1)	26	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			ATCCAGCCCACGGCCACCACC	0.582000													7	41					0	0	1	0	0
CTSO	1519	broad.mit.edu	37	4	156847223	156847223	+	Splice_Site	SNP	C	C	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr4:156847223C>A	ENST00000433477.3	-	8	1001		c.e8-1			NM_001334.2	NP_001325.1	P43234	CATO_HUMAN	cathepsin O						proteolysis	lysosome	cysteine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(3)|prostate(1)	16	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.05)|Kidney(143;0.0627)|COAD - Colon adenocarcinoma(41;0.148)		TCTGCAATACCTAAGGGAAAA	0.313000													6	20					0.217242	0.220139	1	1	0
FLNC	2318	broad.mit.edu	37	7	128491575	128491575	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr7:128491575G>T	ENST00000325888.8	+	35	5996	c.5735G>T	c.(5734-5736)gGc>gTc	p.G1912V	RP11-309L24.2_ENST00000469965.1_RNA|FLNC_ENST00000346177.6_Missense_Mutation_p.G1879V	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1912					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						AACAAGGATGGCACCTGCACC	0.602000													12	58					5.50884e-06	7.15678e-06	1	1	0
IGKV3-7	28915	broad.mit.edu	37	2	89278276	89278276	+	RNA	SNP	C	C	G			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr2:89278276C>G	ENST00000390247.2	-	0	155																											TACAATTTCTCTGGTGGTATC	0.448000													8	79					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59405017	59405017	+	Silent	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr8:59405017G>A	ENST00000301645.3	-	5	1247	c.1110C>T	c.(1108-1110)ttC>ttT	p.F370F		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	370					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				GGTGCAAAGTGAAATCCTCCT	0.408000									Neonatal Giant Cell Hepatitis				7	77					0	0	1	0	0
MMEL1	79258	broad.mit.edu	37	1	2541155	2541155	+	Silent	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:2541155G>A	ENST00000288709.6	-	5	621	c.381C>T	c.(379-381)taC>taT	p.Y127Y	MMEL1_ENST00000502556.1_Silent_p.Y136Y|MMEL1_ENST00000378412.3_Silent_p.Y136Y	NM_033467.3	NP_258428.2	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	136					proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity			cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|urinary_tract(1)	27	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CAAAGATGCTGTATCTTGAGT	0.617000													9	47					0	0	1	0	0
UBP1	7342	broad.mit.edu	37	3	33442469	33442469	+	Silent	SNP	T	T	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr3:33442469T>C	ENST00000283629.3	-	10	1600	c.1071A>G	c.(1069-1071)tcA>tcG	p.S357S	UBP1_ENST00000486388.1_5'UTR|UBP1_ENST00000283628.5_Silent_p.S357S|UBP1_ENST00000447368.2_Silent_p.S321S	NM_001128161.1|NM_014517.4	NP_001121633.1|NP_055332.3	Q9NZI7	UBIP1_HUMAN	upstream binding protein 1 (LBP-1a)	357					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|urinary_tract(2)	23						CAGAGGTCTGTGAAGCTCCAT	0.353000													11	43					0	0	1	0	0
CLK2	1196	broad.mit.edu	37	1	155239391	155239391	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:155239391C>A	ENST00000368361.4	-	3	602	c.287G>T	c.(286-288)cGg>cTg	p.R96L	CLK2_ENST00000361168.5_Missense_Mutation_p.R96L|CLK2_ENST00000536801.1_Missense_Mutation_p.R96L|CLK2_ENST00000355560.4_Missense_Mutation_p.R95L			P49760	CLK2_HUMAN	CDC-like kinase 2	96						nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	22	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			ATAGGAATGCCGATAGTCTGT	0.587000								Other conserved DNA damage response genes					20	118					1.64113e-05	2.06159e-05	1	1	0
RFWD3	55159	broad.mit.edu	37	16	74660379	74660379	+	Silent	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr16:74660379G>A	ENST00000361070.4	-	12	2140	c.2043C>T	c.(2041-2043)atC>atT	p.I681I	RFWD3_ENST00000571750.1_Silent_p.I681I	NM_018124.3	NP_060594.3	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	681					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	26						GGCAGGAGCAGATTGGATTTC	0.443000													15	64					0	0	1	0	0
SLC38A11	151258	broad.mit.edu	37	2	165768148	165768148	+	Nonsense_Mutation	SNP	C	C	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr2:165768148C>A	ENST00000303735.4	-	8	1057	c.727G>T	c.(727-729)Gag>Tag	p.E243*	SLC38A11_ENST00000409662.1_Nonsense_Mutation_p.E265*|SLC38A11_ENST00000409058.1_Nonsense_Mutation_p.E296*|SLC38A11_ENST00000409149.3_Nonsense_Mutation_p.E265*	NM_173512.2	NP_775783.1	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	265					amino acid transport|sodium ion transport	integral to membrane				endometrium(2)|large_intestine(4)|lung(8)|ovary(1)	15						GCGCTTACCTCTCTTGTCACA	0.388000													6	28					1	1	1	1	0
ZEB2	9839	broad.mit.edu	37	2	145155885	145155885	+	Silent	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr2:145155885G>T	ENST00000558170.2	-	8	4053	c.2869C>A	c.(2869-2871)Cgg>Agg	p.R957R	ZEB2_ENST00000409487.3_Silent_p.R957R|ZEB2_ENST00000539609.3_Silent_p.R933R|ZEB2_ENST00000303660.4_Silent_p.R957R	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	957						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding	p.R957W(1)		breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		CCTTGTTTCCGCTGGTACTTT	0.408000													11	67					6.40141e-05	7.72234e-05	1	1	0
DCHS2	54798	broad.mit.edu	37	4	155250781	155250781	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr4:155250781G>T	ENST00000357232.3	-	11	2446	c.2447C>A	c.(2446-2448)tCc>tAc	p.S816Y	DCHS2_ENST00000339452.1_Missense_Mutation_p.S1271Y	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	816	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TCGTGGTGGGGAGCCGCGGTC	0.547000													6	49					0.0381472	0.0405481	1	1	0
OR7A5	26659	broad.mit.edu	37	19	14938325	14938325	+	Silent	SNP	A	A	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr19:14938325A>C	ENST00000322301.3	-	2	816	c.729T>G	c.(727-729)tcT>tcG	p.S243S	OR7A5_ENST00000594432.1_Silent_p.S243S|OR7A5_ENST00000601611.1_Intron			Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A, member 5	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26						CTGAGAGGTGAGATGCACAGG	0.468000													5	73					0	0	1	0	0
CROT	54677	broad.mit.edu	37	7	87022301	87022301	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr7:87022301G>T	ENST00000331536.3	+	17	1821	c.1636G>T	c.(1636-1638)Gtt>Ttt	p.V546F	CROT_ENST00000442291.1_Missense_Mutation_p.V546F|CROT_ENST00000419147.2_Missense_Mutation_p.V574F	NM_021151.3	NP_066974.2	Q9UKG9	OCTC_HUMAN	carnitine O-octanoyltransferase	546					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	AACAAGTCTGGTTGGCTATTT	0.403000													20	123					1.33834e-09	1.8663e-09	1	1	0
UBR4	23352	broad.mit.edu	37	1	19440472	19440472	+	Nonsense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:19440472G>T	ENST00000375267.2	-	76	11298	c.11295C>A	c.(11293-11295)tgC>tgA	p.C3765*	UBR4_ENST00000375218.3_Nonsense_Mutation_p.C180*|UBR4_ENST00000375254.3_Nonsense_Mutation_p.C3765*|UBR4_ENST00000375217.2_Nonsense_Mutation_p.C3758*|UBR4_ENST00000375226.2_Nonsense_Mutation_p.C3741*			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	3765					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CATTCACTTTGCAGAGCAGGT	0.512000											OREG0013168	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	129					9.57634e-11	1.34778e-10	1	1	0
OR5L2	26338	broad.mit.edu	37	11	55595409	55595409	+	Missense_Mutation	SNP	T	T	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr11:55595409T>A	ENST00000378397.1	+	1	715	c.715T>A	c.(715-717)Tcc>Acc	p.S239T		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				CAAAGCTTTCTCCACCTGTGC	0.483000										HNSCC(27;0.073)			16	93					0	0	1	0	0
SLC5A1	6523	broad.mit.edu	37	22	32477942	32477942	+	Silent	SNP	C	C	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr22:32477942C>A	ENST00000266088.4	+	6	817	c.567C>A	c.(565-567)gcC>gcA	p.A189A	SLC5A1_ENST00000543737.1_Silent_p.A62A	NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	189					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						CAATCACTGCCCTTTACACAA	0.473000													7	56					8.12818e-05	9.5774e-05	1	1	0
SLC24A3	57419	broad.mit.edu	37	20	19664974	19664974	+	Silent	SNP	C	C	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr20:19664974C>T	ENST00000328041.6	+	11	1253	c.1056C>T	c.(1054-1056)atC>atT	p.I352I		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	352						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GCATGTTGATCAATGAGGTAC	0.532000													4	20					0	0	1	0	0
GPR114	221188	broad.mit.edu	37	16	57601917	57601917	+	Missense_Mutation	SNP	C	C	T	rs143764238		TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr16:57601917C>T	ENST00000340339.4	+	9	1494	c.971C>T	c.(970-972)gCg>gTg	p.A324V	GPR114_ENST00000394361.4_3'UTR|GPR114_ENST00000349457.3_Missense_Mutation_p.A324V	NM_153837.1	NP_722579.1	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114	324					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(5)|ovary(2)|stomach(1)|urinary_tract(1)	23						CTGCACTACGCGCTGCTCAGC	0.607000													5	29					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr12:25398284C>T	ENST00000311936.3	-	2	226	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000256078.4_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			6	24					0	0	1	0	0
FOLH1	2346	broad.mit.edu	37	11	49204780	49204780	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr11:49204780G>A	ENST00000340334.7	-	8	1164	c.796C>T	c.(796-798)Cgt>Tgt	p.R266C	FOLH1_ENST00000356696.3_Missense_Mutation_p.R281C|FOLH1_ENST00000533034.1_Missense_Mutation_p.R266C|FOLH1_ENST00000343844.4_5'UTR|FOLH1_ENST00000256999.2_Missense_Mutation_p.R281C	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	281					proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity	p.R281C(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	GCAATTCCACGCCTATAAGCA	0.343000													6	33					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35425721	35425721	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr8:35425721G>C	ENST00000287272.2	+	3	448	c.428G>C	c.(427-429)gGt>gCt	p.G143A	UNC5D_ENST00000453357.2_Missense_Mutation_p.G138A|UNC5D_ENST00000404895.2_Missense_Mutation_p.G143A|UNC5D_ENST00000420357.1_Missense_Mutation_p.G143A|UNC5D_ENST00000416672.1_Missense_Mutation_p.G143A			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	143	Ig-like.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		AGCCACCTGGGTACCTCCAAG	0.522000													21	70					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103901076	103901076	+	Silent	SNP	G	G	C			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr10:103901076G>C	ENST00000278070.2	+	5	2850	c.2811G>C	c.(2809-2811)ctG>ctC	p.L937L	PPRC1_ENST00000413464.2_Silent_p.L937L	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	937	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		ATCCTTGCCTGCCCCCCCCAC	0.602000													4	33					0	0	1	0	0
CCDC9	26093	broad.mit.edu	37	19	47761660	47761660	+	Splice_Site	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr19:47761660G>A	ENST00000221922.6	+	2	225	c.3_splice	c.e2+1	p.M1_splice		NM_015603.2	NP_056418.1	Q9Y3X0	CCDC9_HUMAN	coiled-coil domain containing 9	1										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|urinary_tract(1)	12		all_cancers(25;0.0432)|all_epithelial(76;0.00812)|Medulloblastoma(540;0.0208)|all_neural(266;0.0416)|Hepatocellular(1079;0.114)		OV - Ovarian serous cystadenocarcinoma(262;8.51e-95)|Epithelial(262;1.15e-92)|all cancers(93;7.67e-84)|GBM - Glioblastoma multiforme(486;0.024)|STAD - Stomach adenocarcinoma(1328;0.183)		CCAGCGAAATGGTGAGGCTGA	0.557000													4	46					0	0	1	0	0
BACH2	60468	broad.mit.edu	37	6	90660323	90660323	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr6:90660323G>A	ENST00000257749.4	-	7	2209	c.1502C>T	c.(1501-1503)cCg>cTg	p.P501L	RP3-512E2.2_ENST00000445838.1_RNA|RP3-512E2.2_ENST00000413986.1_RNA|BACH2_ENST00000537989.1_Missense_Mutation_p.P501L|BACH2_ENST00000343122.3_Missense_Mutation_p.P501L	NM_021813.2	NP_068585.1	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 2	501						nucleus	protein dimerization activity|sequence-specific DNA binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	45		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		GATTGGTACCGGGCAGCTGGT	0.662000													14	45					0	0	1	0	0
MINK1	50488	broad.mit.edu	37	17	4789857	4789857	+	Silent	SNP	G	G	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr17:4789857G>A	ENST00000355280.6	+	10	1081	c.885G>A	c.(883-885)gaG>gaA	p.E295E	MINK1_ENST00000453408.3_Silent_p.E295E|MINK1_ENST00000347992.7_Silent_p.E295E	NM_001024937.3|NM_015716.4|NM_153827.4	NP_001020108.1|NP_056531.1|NP_722549.2	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1	295					JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						AGCCCACGGAGCGGCAGGTCC	0.587000													12	63					0	0	1	0	0
SGK2	10110	broad.mit.edu	37	20	42195004	42195004	+	Missense_Mutation	SNP	T	T	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr20:42195004T>A	ENST00000341458.4	+	1	268	c.49T>A	c.(49-51)Tgc>Agc	p.C17S	SGK2_ENST00000373077.1_Intron|SGK2_ENST00000373092.3_Intron|SGK2_ENST00000373100.1_Intron|SGK2_ENST00000426287.1_Missense_Mutation_p.C17S|SGK2_ENST00000423407.3_Intron	NM_016276.3	NP_057360.2	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2	17					intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CGGTGGCAGGTGCACAGGTAG	0.582000													5	77					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr13:25161397C>G	ENST00000453498.1	+	0	921																											TGAAACATCTCTACAACTGGA	0.343000													6	41					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100675990	100675990	+	Silent	SNP	C	C	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr7:100675990C>T	ENST00000306151.4	+	3	1357	c.1293C>T	c.(1291-1293)agC>agT	p.S431S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	431	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GTGAAGCCAGCTCATCTCCCA	0.493000													50	320					0	0	1	0	0
PHRF1	57661	broad.mit.edu	37	11	605711	605711	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr11:605711G>T	ENST00000264555.5	+	12	1569	c.1441G>T	c.(1441-1443)Gtg>Ttg	p.V481L	PHRF1_ENST00000416188.2_Missense_Mutation_p.V480L|PHRF1_ENST00000413872.2_Missense_Mutation_p.V479L|PHRF1_ENST00000533464.1_Missense_Mutation_p.V477L	NM_020901.2	NP_065952.2	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	481							RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						GCCCGTCTCCGTGGGGCTTTC	0.652000													5	33					0.014758	0.0159093	1	1	0
PPARGC1A	10891	broad.mit.edu	37	4	23797458	23797458	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr4:23797458C>A	ENST00000264867.2	-	13	2503	c.2384G>T	c.(2383-2385)aGc>aTc	p.S795I	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	795					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				CCTGCGCAAGCTTCTCTGAGC	0.448000													10	55					6.40141e-05	7.72234e-05	1	1	0
CDK18	5129	broad.mit.edu	37	1	205495937	205495937	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:205495937G>T	ENST00000360066.2	+	8	1002	c.701G>T	c.(700-702)gGg>gTg	p.G234V	CDK18_ENST00000429964.2_Missense_Mutation_p.G234V|CDK18_ENST00000506784.1_Missense_Mutation_p.G264V|CDK18_ENST00000509056.1_3'UTR	NM_002596.3|NM_212502.2|NM_212503.2	NP_002587.2|NP_997667.1|NP_997668.1	Q07002	CDK18_HUMAN	cyclin-dependent kinase 18	232	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			breast(2)|endometrium(2)|large_intestine(2)|lung(10)|stomach(2)|urinary_tract(1)	19						GACCACTGTGGGAACCTCATG	0.627000													19	90					1.2644e-06	1.67121e-06	1	1	0
KIAA0556	23247	broad.mit.edu	37	16	27751673	27751673	+	Silent	SNP	T	T	A	rs148704304	byFrequency	TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr16:27751673T>A	ENST00000261588.4	+	15	2074	c.2055T>A	c.(2053-2055)acT>acA	p.T685T		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	685										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						AGAATTCTACTAATTGCAGGA	0.488000													12	109					0	0	1	0	0
TMEM119	338773	broad.mit.edu	37	12	108985527	108985527	+	Silent	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr12:108985527G>T	ENST00000392806.3	-	2	801	c.633C>A	c.(631-633)ggC>ggA	p.G211G		NM_181724.2	NP_859075.2	Q4V9L6	TM119_HUMAN	transmembrane protein 119	211						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|skin(1)	7						CCTCCTGGCTGCCCTTCTCCT	0.692000													9	41					5.4927e-09	7.52154e-09	1	1	0
CDH7	1005	broad.mit.edu	37	18	63547762	63547762	+	Nonsense_Mutation	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr18:63547762G>T	ENST00000397968.2	+	12	2416	c.1990G>T	c.(1990-1992)Gaa>Taa	p.E664*	CDH7_ENST00000323011.3_Nonsense_Mutation_p.E664*	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	664					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				GGAGGACACGGAAGCGTTTGA	0.498000													16	45					2.48551e-13	3.63266e-13	1	1	0
PCDHA6	56142	broad.mit.edu	37	5	140208077	140208077	+	Missense_Mutation	SNP	C	C	A	rs139629080		TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr5:140208077C>A	ENST00000529310.1	+	1	515	c.401C>A	c.(400-402)cCg>cAg	p.P134Q	PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.P134Q|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTTGTTCCCGGTAGAGGAA	0.547000													7	131					8.12818e-05	9.5774e-05	1	1	0
MCM2	4171	broad.mit.edu	37	3	127325633	127325633	+	Silent	SNP	C	C	T	rs143514266	byFrequency	TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr3:127325633C>T	ENST00000265056.7	+	6	1318	c.1074C>T	c.(1072-1074)gcC>gcT	p.A358A		NM_004526.2	NP_004517.2	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	358					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(2)|stomach(1)	6						GCCAGTCGGCCGGCCCCTTTG	0.577000													6	64					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248437045	248437045	+	Silent	SNP	G	G	T			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr1:248437045G>T	ENST00000318021.2	-	1	93	c.72C>A	c.(70-72)gtC>gtA	p.V24V		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCATGAAGAGGACTTGGTGGG	0.483000													25	75					2.48779e-11	3.5674e-11	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141243003	141243003	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr2:141243003C>G	ENST00000389484.3	-	59	10305	c.9334G>C	c.(9334-9336)Gaa>Caa	p.E3112Q		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3112					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGGATACTTCAATGATTCTT	0.408000										TSP Lung(27;0.18)			6	44					0	0	1	0	0
HOXD10	3236	broad.mit.edu	37	2	176983781	176983782	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr2:176983781_176983782delAA	ENST00000249501.4	+	2	1100_1101	c.845_846delAA	c.(844-846)gfs	p.E282fs	HOXD10_ENST00000490088.2_3'UTR	NM_002148.3	NP_002139.2	P28358	HXD10_HUMAN	homeobox D10	282						nucleus	sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		CTGGAATTAGAAAAAGAGTTCT	0.470													9	85	---	---	---	---					
GPR98	84059	broad.mit.edu	37	5	90159639	90159639	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr5:90159639delC	ENST00000405460.2	+	83	17917	c.17821delC	c.(17821-17823)tgfs	p.L5941fs	GPR98_ENST00000425867.2_Frame_Shift_Del_p.L1602fs	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	5941					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGCTAAACTTCTGACTCACAT	0.423													23	103	---	---	---	---					
PCDHB11	56125	broad.mit.edu	37	5	140581672	140581672	+	Frame_Shift_Del	DEL	G	G	-			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr5:140581672delG	ENST00000354757.3	+	1	2325	c.2325delG	c.(2323-2325)cafs	p.Q775fs	PCDHB11_ENST00000536699.1_Frame_Shift_Del_p.Q410fs	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		775					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTAATATCCAGGCAAAAGGTC	0.413													7	54	---	---	---	---					
RP11-428C19.4	0	broad.mit.edu	37	11	19296062	19296063	+	RNA	INS	-	-	A	rs34104745		TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr11:19296062_19296063insA	ENST00000527978.1	+	0	339																											gactctgtttcaaaaaaaaaaa	0.480													3	6	---	---	---	---					
OR4S2	219431	broad.mit.edu	37	11	55418468	55418468	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr11:55418468delC	ENST00000312422.2	+	1	89	c.89delC	c.(88-90)ttfs	p.S30fs		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				GTGGTGTTTTCTTTCTTCTAC	0.388													7	87	---	---	---	---					
HERC2P2	400322	broad.mit.edu	37	15	23312379	23312379	+	RNA	DEL	C	C	-			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr15:23312379delC	ENST00000560464.1	-	0	3118																											TTGTTAttttctttttttttt	0.398													4	7	---	---	---	---					
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	-	G	rs2981599		TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr16:3119304_3119305insG	ENST00000525643.2	+	7	847_848	c.515_516insG	c.(514-516)gaafs	p.E172fs	IL32_ENST00000526464.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000551513.1_Frame_Shift_Ins_p.E209fs|IL32_ENST00000531965.1_Frame_Shift_Ins_p.E162fs|IL32_ENST00000008180.9_Frame_Shift_Ins_p.E152fs|IL32_ENST00000551122.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000382213.3_Frame_Shift_Ins_p.E163fs|IL32_ENST00000529699.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000396887.3_Frame_Shift_Ins_p.E115fs|IL32_ENST00000534507.1_Frame_Shift_Ins_p.E218fs|IL32_ENST00000549213.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000325568.5_Frame_Shift_Ins_p.E172fs|IL32_ENST00000548246.1_Frame_Shift_Ins_p.E132fs|IL32_ENST00000440815.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000530538.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000528163.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000529550.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000548476.1_Frame_Shift_Ins_p.E218fs|IL32_ENST00000552664.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000396890.2_Frame_Shift_Ins_p.E218fs|IL32_ENST00000530890.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000548652.1_Frame_Shift_Ins_p.E163fs|IL32_ENST00000552356.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000552936.1_Frame_Shift_Ins_p.E196fs|IL32_ENST00000444393.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000533097.2_Frame_Shift_Ins_p.E172fs			P24001	IL32_HUMAN	interleukin 32	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	15						CCACGGGGGGACAAGGAGGAGC	0.574													8	243	---	---	---	---					
CMTR2	55783	broad.mit.edu	37	16	71318334	71318334	+	Frame_Shift_Del	DEL	A	A	-			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr16:71318334delA	ENST00000338099.5	-	3	1826	c.1490delT	c.(1489-1491)tgfs	p.L497fs	FTSJD1_ENST00000434935.2_Frame_Shift_Del_p.L497fs			Q8IYT2	FTSJ1_HUMAN		497						integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CTTTCCCTCCAAAATATGCCA	0.363													16	50	---	---	---	---					
SLC35G3	146861	broad.mit.edu	37	17	33521207	33521207	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr17:33521207delC	ENST00000297307.5	-	1	205	c.120delG	c.(118-120)ctfs	p.L41fs		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	41						integral to membrane											GGGCCACCAGCAGGCCACTGG	0.667													9	68	---	---	---	---					
AC007204.2	0	broad.mit.edu	37	19	20067365	20067367	+	RNA	DEL	AGG	AGG	-			TCGA-J2-A4AG-01A-11D-A24D-08	TCGA-J2-A4AG-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7af4b457-894f-481c-bdbd-6193a4768598	97c2e58b-97a4-406a-8c0e-25f468156922	g.chr19:20067365_20067367delAGG	ENST00000592245.1	+	0	72																											AAGCTGGGCAAGGAGAACTCGGG	0.621													3	5	---	---	---	---