Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RYR3	6263	broad.mit.edu	37	15	33872315	33872315	+	Silent	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr15:33872315C>A	ENST00000389232.4	+	13	1477	c.1407C>A	c.(1405-1407)ctC>ctA	p.L469L	RYR3_ENST00000415757.3_Silent_p.L469L	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	469					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCCGCTCACTCAAAAACAGAC	0.443000													6	13					0.0215528	0.0228072	1	1	0
VCAN	1462	broad.mit.edu	37	5	82837386	82837386	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr5:82837386G>T	ENST00000265077.3	+	8	9129	c.8564G>T	c.(8563-8565)gGc>gTc	p.G2855V	VCAN_ENST00000342785.4_Intron|VCAN_ENST00000502527.2_Intron|VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000343200.5_Missense_Mutation_p.G1868V|VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000512090.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2855	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ATAGACGTCGGCTCATCTGTA	0.468000													17	112					4.14922e-12	7.21603e-12	1	1	0
PCF11	51585	broad.mit.edu	37	11	82879581	82879581	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr11:82879581G>C	ENST00000298281.4	+	8	2656	c.2204G>C	c.(2203-2205)gGc>gCc	p.G735A		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	735	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						AGATTCGCCGGCCTGGATACA	0.448000													14	99					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63547940	63547940	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr18:63547940G>T	ENST00000397968.2	+	12	2594	c.2168G>T	c.(2167-2169)gGt>gTt	p.G723V	CDH7_ENST00000323011.3_Missense_Mutation_p.G723V	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	723					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				GTTGATCCTGGTGCTCCTCCT	0.408000													17	110					1.5739e-10	2.55918e-10	1	1	0
VPS13C	54832	broad.mit.edu	37	15	62270944	62270944	+	Missense_Mutation	SNP	T	T	C	rs143708476		TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr15:62270944T>C	ENST00000261517.5	-	23	2244	c.2171A>G	c.(2170-2172)aAc>aGc	p.N724S	VPS13C_ENST00000249837.3_Missense_Mutation_p.N681S|VPS13C_ENST00000395896.4_Missense_Mutation_p.N724S|VPS13C_ENST00000395898.3_Missense_Mutation_p.N681S	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	724					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						ATCTTTACTGTTGAGCTAAAA	0.294000													8	54					0	0	1	0	0
INSC	387755	broad.mit.edu	37	11	15197518	15197518	+	Silent	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr11:15197518C>A	ENST00000379554.3	+	3	475	c.429C>A	c.(427-429)gcC>gcA	p.A143A	INSC_ENST00000528567.1_Silent_p.A96A|INSC_ENST00000424273.1_Silent_p.A96A|INSC_ENST00000530161.1_Silent_p.A96A|INSC_ENST00000379556.3_Silent_p.A96A|INSC_ENST00000525218.1_Silent_p.A96A	NM_001031853.3	NP_001027024.3	Q1MX18	INSC_HUMAN	inscuteable homolog (Drosophila)	143					cell differentiation|nervous system development	cytoplasm	binding			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(3)|lung(24)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49						AGAAGCTGGCCCAGGACCGCT	0.647000													3	20					1	1	1	1	0
RYR2	6262	broad.mit.edu	37	1	237729883	237729883	+	Silent	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:237729883G>A	ENST00000366574.2	+	28	3548	c.3231G>A	c.(3229-3231)gtG>gtA	p.V1077V	RYR2_ENST00000360064.6_Silent_p.V1075V|RYR2_ENST00000542537.1_Silent_p.V1061V	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1077	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAGCCGAAGTGTGCAGCGGCA	0.502000													7	48					0	0	1	0	0
SMARCA1	6594	broad.mit.edu	37	X	128599832	128599832	+	Silent	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:128599832G>A	ENST00000371122.4	-	22	2935	c.2806C>T	c.(2806-2808)Ctg>Ttg	p.L936L	SMARCA1_ENST00000371121.3_Silent_p.L924L|SMARCA1_ENST00000371123.1_Silent_p.L924L	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	936					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						TTGGCATCCAGGGCTTTCTTG	0.348000													13	186					0	0	1	0	0
BRWD3	254065	broad.mit.edu	37	X	79932147	79932147	+	Silent	SNP	T	T	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:79932147T>C	ENST00000373275.4	-	41	5586	c.5370A>G	c.(5368-5370)gaA>gaG	p.E1790E		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1790										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						CCCTGGCTTTTTCTGTCATTT	0.353000													11	69					0	0	1	0	0
ZNF841	284371	broad.mit.edu	37	19	52569093	52569093	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr19:52569093T>C	ENST00000389534.4	-	7	2501	c.2042A>G	c.(2041-2043)tAc>tGc	p.Y681C	ZNF841_ENST00000359973.2_Intron|ZNF841_ENST00000594295.1_Missense_Mutation_p.Y681C|ZNF432_ENST00000598446.1_Intron|ZNF841_ENST00000426391.2_Missense_Mutation_p.Y565C	NM_001136499.1	NP_001129971.1	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	565					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|lung(3)	11						ATTACAGTGGTAAGGGTTCTC	0.393000													6	49					0	0	1	0	0
GOLT1A	127845	broad.mit.edu	37	1	204172024	204172024	+	Splice_Site	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:204172024G>A	ENST00000308302.3	-	2	302	c.117_splice	c.e2+1	p.N39_splice		NM_198447.1	NP_940849.1	Q6ZVE7	GOT1A_HUMAN	golgi transport 1A	39					protein transport|vesicle-mediated transport	Golgi membrane|integral to membrane				kidney(1)|lung(2)|urinary_tract(1)	4	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.244)			GGAGACTCACGTTTCCAAAGG	0.498000													6	64					0	0	1	0	0
RPAP1	26015	broad.mit.edu	37	15	41814988	41814988	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr15:41814988T>A	ENST00000304330.4	-	19	2833	c.2717A>T	c.(2716-2718)cAg>cTg	p.Q906L	RPAP1_ENST00000561603.1_Missense_Mutation_p.Q906L	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	906	Leu-rich.					nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CTTGTGGATCTGGGCCAGGGT	0.612000													5	29					0	0	1	0	0
IRF6	3664	broad.mit.edu	37	1	209969711	209969711	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:209969711C>A	ENST00000367021.3	-	4	533	c.361G>T	c.(361-363)Ggc>Tgc	p.G121C	IRF6_ENST00000542854.1_Missense_Mutation_p.G26C	NM_006147.3	NP_006138.1	O14896	IRF6_HUMAN	interferon regulatory factor 6	121					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	28				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		ATGATCGAGCCCTGGGGCTGA	0.512000										HNSCC(57;0.16)			6	47					5.9392e-07	8.13589e-07	1	1	0
PCDH11X	27328	broad.mit.edu	37	X	91132560	91132560	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:91132560G>T	ENST00000373094.1	+	2	2166	c.1321G>T	c.(1321-1323)Gct>Tct	p.A441S	PCDH11X_ENST00000373097.1_Missense_Mutation_p.A441S|PCDH11X_ENST00000395337.2_Missense_Mutation_p.A441S|PCDH11X_ENST00000504220.1_Missense_Mutation_p.A441S|PCDH11X_ENST00000361655.2_Missense_Mutation_p.A441S|PCDH11X_ENST00000298274.8_Missense_Mutation_p.A441S|PCDH11X_ENST00000361724.1_Missense_Mutation_p.A441S|PCDH11X_ENST00000373088.1_Missense_Mutation_p.A441S|PCDH11X_ENST00000406881.1_Missense_Mutation_p.A441S	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	441	Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						GGCTGCAGATGCTGGCAAACC	0.408000													12	137					4.7546e-09	7.37148e-09	1	1	0
NENF	29937	broad.mit.edu	37	1	212617691	212617691	+	Silent	SNP	A	A	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:212617691A>T	ENST00000366988.3	+	3	306	c.249A>T	c.(247-249)ggA>ggT	p.G83G	NENF_ENST00000473900.1_3'UTR	NM_013349.4	NP_037481.1	Q9UMX5	NENF_HUMAN	neudesin neurotrophic factor	83	Cytochrome b5 heme-binding.					extracellular space	heme binding			endometrium(1)|kidney(1)|large_intestine(2)	4				all cancers(67;0.00967)|OV - Ovarian serous cystadenocarcinoma(81;0.0108)|GBM - Glioblastoma multiforme(131;0.0325)|Epithelial(68;0.132)		AGTTTTATGGACGAGGAGCCC	0.572000													6	41					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107289059	107289059	+	Silent	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr9:107289059C>A	ENST00000277216.3	-	1	431	c.432G>T	c.(430-432)ctG>ctT	p.L144L		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	144					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						ATACAGAAGTCAGCAGTACAT	0.423000													13	157					4.3838e-07	6.13119e-07	1	1	0
ARAP1	116985	broad.mit.edu	37	11	72410115	72410115	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr11:72410115G>A	ENST00000359373.5	-	18	3327	c.2476C>T	c.(2476-2478)Cgg>Tgg	p.R826W	ARAP1_ENST00000495878.1_5'UTR|ARAP1_ENST00000334211.8_Missense_Mutation_p.R581W|ARAP1_ENST00000426523.1_Missense_Mutation_p.R581W|ARAP1_ENST00000393609.3_Missense_Mutation_p.R826W|ARAP1_ENST00000393605.3_Missense_Mutation_p.R586W|ARAP1_ENST00000429686.1_Missense_Mutation_p.R520W|ARAP1_ENST00000455638.2_Missense_Mutation_p.R826W			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	826	PH 3.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						AGGTACAGCCGTTCTCCCTCC	0.597000													8	130					0	0	1	0	0
NGLY1	55768	broad.mit.edu	37	3	25775411	25775411	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr3:25775411C>A	ENST00000428257.1	-	8	1265	c.1158G>T	c.(1156-1158)aaG>aaT	p.K386N	NGLY1_ENST00000467224.1_5'UTR|NGLY1_ENST00000417874.2_Missense_Mutation_p.K362N|NGLY1_ENST00000422724.2_3'UTR|NGLY1_ENST00000396649.3_Missense_Mutation_p.K404N|NGLY1_ENST00000280700.5_Missense_Mutation_p.K404N	NM_001145293.1	NP_001138765.1	Q96IV0	NGLY1_HUMAN	N-glycanase 1	404					glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)	18						CTTCTTTAACCTTAGTTCTTC	0.343000													9	77					2.17888e-05	2.75807e-05	1	1	0
GRIA3	2892	broad.mit.edu	37	X	122551379	122551379	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:122551379G>T	ENST00000264357.5	+	11	1919	c.1627G>T	c.(1627-1629)Ggc>Tgc	p.G543C	GRIA3_ENST00000542149.1_Missense_Mutation_p.G543C|GRIA3_ENST00000371251.1_Missense_Mutation_p.G543C|GRIA3_ENST00000541091.1_Missense_Mutation_p.G527C|GRIA3_ENST00000371256.5_Missense_Mutation_p.G543C	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	543					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	ATCAAAACCAGGCGTATTCTC	0.423000													20	293					5.35267e-07	7.43426e-07	1	1	0
MYL10	93408	broad.mit.edu	37	7	101265410	101265410	+	Silent	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr7:101265410C>A	ENST00000223167.4	-	5	597	c.420G>T	c.(418-420)acG>acT	p.T140T		NM_138403.4	NP_612412.2	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	140						mitochondrion	calcium ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	12						TCAGGAACACCGTGAAGTTGA	0.622000													9	77					0.00829132	0.00906155	1	1	0
OR8H2	390151	broad.mit.edu	37	11	55873323	55873323	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr11:55873323G>T	ENST00000313503.1	+	1	805	c.805G>T	c.(805-807)Gga>Tga	p.G269*		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	269					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TTATTCCTTGGGAAGAGATCA	0.363000										HNSCC(53;0.14)			17	133					3.45872e-05	4.35059e-05	1	1	0
SF3B1	23451	broad.mit.edu	37	2	198266512	198266512	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr2:198266512C>A	ENST00000335508.5	-	16	2415	c.2324G>T	c.(2323-2325)cGa>cTa	p.R775L		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	775					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CTGGAATTCTCGAATAAGGAT	0.358000			Mis		myelodysplastic syndrome								10	89					0.00621372	0.00686598	1	1	0
TRIOBP	11078	broad.mit.edu	37	22	38119239	38119239	+	Missense_Mutation	SNP	C	C	T	rs139454337	by1000genomes	TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr22:38119239C>T	ENST00000406386.3	+	7	931	c.676C>T	c.(676-678)Cgg>Tgg	p.R226W	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	226					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GGCAAGGCTCCGGGGAGAAAG	0.652000													4	27					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20673935	20673935	+	Missense_Mutation	SNP	G	G	T	rs142440636	byFrequency	TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr11:20673935G>T	ENST00000525748.1	+	15	2444	c.2171G>T	c.(2170-2172)tGt>tTt	p.C724F	SLC6A5_ENST00000528440.1_3'UTR	NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	724					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	ATGCTCGCCTGTTCCGTCATC	0.463000													19	130					5.03518e-11	8.46249e-11	1	1	0
DSC3	1825	broad.mit.edu	37	18	28611064	28611064	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr18:28611064C>T	ENST00000434452.1	-	3	383	c.229G>A	c.(229-231)Ggg>Agg	p.G77R	DSC3_ENST00000360428.4_Missense_Mutation_p.G77R	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	77					homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			TACACTGACCCATCATTTAGA	0.413000													4	47					0	0	1	0	0
SEC63	11231	broad.mit.edu	37	6	108224067	108224067	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr6:108224067C>A	ENST00000369002.4	-	12	1369	c.1190G>T	c.(1189-1191)cGg>cTg	p.R397L		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	397	SEC63 1.				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		ATTAGAAACCCGTCTAAGATT	0.393000													11	169					4.68919e-08	6.99879e-08	1	1	0
SPTA1	6708	broad.mit.edu	37	1	158623173	158623173	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:158623173G>C	ENST00000368148.3	-	22	3259	c.3079C>G	c.(3079-3081)Cca>Gca	p.P1027A	SPTA1_ENST00000368147.3_Missense_Mutation_p.P1027A	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1027	SH3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TAGACAGCTGGGACAATGCCC	0.552000													14	86					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36697096	36697096	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr22:36697096G>T	ENST00000216181.5	-	22	2869	c.2639C>A	c.(2638-2640)gCa>gAa	p.A880E		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	880					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						CAATTTCTCTGCCATGAGCTG	0.592000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated		OREG0026520	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	57					7.48243e-07	1.00435e-06	1	1	0
DNAH10	196385	broad.mit.edu	37	12	124297757	124297757	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr12:124297757A>T	ENST00000409039.3	+	19	2862	c.2837A>T	c.(2836-2838)cAg>cTg	p.Q946L		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	946	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGCCCACCTCAGAAGGGGGAG	0.388000													10	57					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101559447	101559447	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr7:101559447A>T	ENST00000360264.3	+	2	136	c.116A>T	c.(115-117)gAg>gTg	p.E39V	CUX1_ENST00000546411.2_Missense_Mutation_p.E28V|CUX1_ENST00000425244.2_Missense_Mutation_p.E39V|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000437600.4_Missense_Mutation_p.E39V|CUX1_ENST00000292538.4_Missense_Mutation_p.E39V|CUX1_ENST00000556210.1_Missense_Mutation_p.E28V|CUX1_ENST00000550008.2_Missense_Mutation_p.E28V|CUX1_ENST00000292535.7_Missense_Mutation_p.E28V|CUX1_ENST00000549414.2_Missense_Mutation_p.E28V|CUX1_ENST00000547394.2_Missense_Mutation_p.E39V	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	28					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						GATGAAAGTGAGCAGTCCAGA	0.512000													15	187					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25427661	25427661	+	RNA	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr15:25427661C>A	ENST00000424208.1	+	0	272					NR_003305.1																						CCGAGGTCCCCAGGAGGGCCC	0.552000													10	151					1.76689e-08	2.69755e-08	1	1	0
NCSTN	23385	broad.mit.edu	37	1	160320040	160320040	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:160320040G>T	ENST00000368063.1	+	6	802	c.522_splice	c.e6+1	p.Q174_splice	NCSTN_ENST00000392212.4_Splice_Site_p.Q174_splice|NCSTN_ENST00000294785.5_Splice_Site_p.Q194_splice|NCSTN_ENST00000535857.1_Splice_Site_p.Q194_splice|NCSTN_ENST00000368065.4_5'UTR|NCSTN_ENST00000459963.1_3'UTR			Q92542	NICA_HUMAN	nicastrin	194					amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(2)	34	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCATCAAGCAGGTAATGACAC	0.448000													17	144					3.32936e-07	4.68924e-07	1	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76528937	76528937	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr16:76528937C>A	ENST00000307431.8	+	15	2593	c.2208C>A	c.(2206-2208)tgC>tgA	p.C736*	CNTNAP4_ENST00000377504.4_Nonsense_Mutation_p.C688*|CNTNAP4_ENST00000478060.1_Nonsense_Mutation_p.C664*|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000476707.1_Nonsense_Mutation_p.C740*	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	737	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AGTATTACTGCAATTGTGATG	0.358000													11	162					4.68919e-08	6.99879e-08	1	1	0
COL21A1	81578	broad.mit.edu	37	6	55939056	55939056	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr6:55939056C>A	ENST00000244728.5	-	20	2336	c.1939G>T	c.(1939-1941)Ggc>Tgc	p.G647C	COL21A1_ENST00000535941.1_Missense_Mutation_p.G647C|COL21A1_ENST00000370808.2_Missense_Mutation_p.G47C|COL21A1_ENST00000370819.1_Missense_Mutation_p.G644C|COL21A1_ENST00000467045.1_5'UTR	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	647	Collagen-like 3.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CCAGGCTGGCCTGGTGAGCCA	0.323000													21	111					1.10513e-12	1.95599e-12	1	1	0
MAGEA4	4103	broad.mit.edu	37	X	151092209	151092209	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:151092209C>A	ENST00000360243.2	+	3	340	c.73C>A	c.(73-75)Ctg>Atg	p.L25M	MAGEA4_ENST00000393921.1_Missense_Mutation_p.L25M|MAGEA4_ENST00000276344.2_Missense_Mutation_p.L25M|MAGEA4_ENST00000370340.3_Missense_Mutation_p.L25M|MAGEA4_ENST00000393920.1_Missense_Mutation_p.L25M|MAGEA4_ENST00000370337.4_Missense_Mutation_p.L25M|MAGEA4_ENST00000370335.1_Missense_Mutation_p.L25M	NM_001011550.1	NP_001011550.1	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	25							protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					GGCCCTGGGCCTGGTGGGTGC	0.612000													5	78					1.23904e-05	1.57839e-05	1	1	0
NLRP2	55655	broad.mit.edu	37	19	55501531	55501531	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr19:55501531A>T	ENST00000543010.1	+	9	2651	c.2508A>T	c.(2506-2508)agA>agT	p.R836S	NLRP2_ENST00000339757.7_Missense_Mutation_p.R814S|NLRP2_ENST00000538819.1_Missense_Mutation_p.R812S|NLRP2_ENST00000537859.1_Missense_Mutation_p.R814S|NLRP2_ENST00000448584.2_Missense_Mutation_p.R836S|NLRP2_ENST00000427260.2_Missense_Mutation_p.R813S|NLRP2_ENST00000391721.4_Missense_Mutation_p.R812S|NLRP2_ENST00000263437.6_Missense_Mutation_p.R833S	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	836					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CAACTTTGAGACACCCCAAGT	0.522000													14	80					0	0	1	0	0
ARHGEF4	50649	broad.mit.edu	37	2	131688546	131688546	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr2:131688546C>A	ENST00000409359.1	+	3	3782	c.2584C>A	c.(2584-2586)Cca>Aca	p.P862T	ARHGEF4_ENST00000326016.5_Missense_Mutation_p.P6T|ARHGEF4_ENST00000409303.1_Missense_Mutation_p.P6T|ARHGEF4_ENST00000392953.3_Missense_Mutation_p.P6T|ARHGEF4_ENST00000428230.2_Missense_Mutation_p.P6T|ARHGEF4_ENST00000525839.1_Missense_Mutation_p.P6T			Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor (GEF) 4	6					apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|cervix(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(4)	29		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		CTGGGAAGAACCAGCAGGTGA	0.572000													6	51					0.00116845	0.00132778	1	1	0
OR4S2	219431	broad.mit.edu	37	11	55418856	55418856	+	Silent	SNP	T	T	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr11:55418856T>A	ENST00000312422.2	+	1	477	c.477T>A	c.(475-477)gcT>gcA	p.A159A		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	159					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				TCCAAGTGGCTCTGGTAGTCC	0.433000													54	304					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101190237	101190237	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:101190237G>T	ENST00000294728.2	+	4	820	c.719G>T	c.(718-720)gGc>gTc	p.G240V	VCAM1_ENST00000370115.1_Missense_Mutation_p.G240V|VCAM1_ENST00000347652.2_Missense_Mutation_p.G240V|VCAM1_ENST00000370119.4_Missense_Mutation_p.G178V	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	240	Ig-like C2-type 3.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	CAAGAAGGTGGCTCTGTGACC	0.413000													9	88					3.09899e-07	4.39572e-07	1	1	0
TMEM176A	55365	broad.mit.edu	37	7	150500761	150500761	+	Silent	SNP	C	C	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr7:150500761C>T	ENST00000484928.1	+	5	977	c.396C>T	c.(394-396)gcC>gcT	p.A132A	TMEM176A_ENST00000004103.3_Silent_p.A132A|TMEM176A_ENST00000461345.1_Silent_p.A73A			Q96HP8	T176A_HUMAN	transmembrane protein 176A	132						integral to membrane				breast(1)|endometrium(1)|lung(7)|ovary(2)|stomach(1)	12			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCATCGCTGCCCTCAAACTTT	0.537000													17	94					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000557334.1_Missense_Mutation_p.G12C|KRAS_ENST00000256078.4_Missense_Mutation_p.G12C|KRAS_ENST00000556131.1_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			7	22					3.09899e-07	4.39572e-07	1	1	0
MUC16	94025	broad.mit.edu	37	19	9058318	9058318	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr19:9058318G>T	ENST00000397910.4	-	3	29331	c.29128C>A	c.(29128-29130)Cct>Act	p.P9710T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9712	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGACTTTCAGGACCCCTGCTC	0.488000													11	44					3.86212e-05	4.76805e-05	1	1	0
IGFN1	91156	broad.mit.edu	37	1	201186487	201186487	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:201186487C>A	ENST00000335211.4	+	17	9798	c.9668C>A	c.(9667-9669)gCa>gAa	p.A3223E	IGFN1_ENST00000295591.8_Missense_Mutation_p.A383E	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						ACATGGACAGCACCTCGGGGC	0.652000													7	96					1.06961e-07	1.56148e-07	1	1	0
ROBO4	54538	broad.mit.edu	37	11	124765390	124765390	+	Silent	SNP	A	A	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr11:124765390A>T	ENST00000306534.3	-	6	1484	c.999T>A	c.(997-999)ccT>ccA	p.P333P	ROBO4_ENST00000533054.1_Silent_p.P188P	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	333	Fibronectin type-III 1.				angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CGTTGCTGTCAGGGCCTCGAG	0.612000													8	89					0	0	1	0	0
KIAA0232	9778	broad.mit.edu	37	4	6863370	6863370	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr4:6863370G>T	ENST00000307659.5	+	7	1716	c.1261G>T	c.(1261-1263)Gag>Tag	p.E421*	KIAA0232_ENST00000425103.1_Nonsense_Mutation_p.E421*	NM_014743.2	NP_055558.2	Q92628	K0232_HUMAN	KIAA0232	421							ATP binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(12)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	41						AAGTAAACTAGAGACCACATA	0.418000													9	71					1.12685e-05	1.454e-05	1	1	0
GALNT14	79623	broad.mit.edu	37	2	31135133	31135133	+	Missense_Mutation	SNP	C	C	T	rs149431826		TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr2:31135133C>T	ENST00000349752.5	-	14	2095	c.1456G>A	c.(1456-1458)Gcc>Acc	p.A486T	GALNT14_ENST00000486564.1_5'UTR|GALNT14_ENST00000420311.2_Missense_Mutation_p.A451T|GALNT14_ENST00000406653.1_Missense_Mutation_p.A466T|GALNT14_ENST00000356174.3_Missense_Mutation_p.A453T|GALNT14_ENST00000324589.5_Missense_Mutation_p.A491T	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	486	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.A486T(1)		cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					ACCACTGGGGCGCCAGGGAAC	0.557000													9	82					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401495	77401495	+	Silent	SNP	T	T	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr16:77401495T>A	ENST00000282849.5	-	4	1039	c.621A>T	c.(619-621)gcA>gcT	p.A207A	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	207					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TCTTCTCCTCTGCTGTCCTTT	0.547000													10	73					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158639307	158639307	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:158639307C>A	ENST00000368148.3	-	14	1904	c.1724G>T	c.(1723-1725)cGt>cTt	p.R575L	SPTA1_ENST00000368147.3_Missense_Mutation_p.R575L	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	575					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton	p.R575H(1)		NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CAGCAATCTACGTCTAGTGGC	0.443000													22	275					2.89027e-11	4.89876e-11	1	1	0
TIAM1	7074	broad.mit.edu	37	21	32492919	32492919	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr21:32492919C>A	ENST00000286827.3	-	29	5014	c.4543G>T	c.(4543-4545)Gtg>Ttg	p.V1515L	TIAM1_ENST00000541036.1_Missense_Mutation_p.V1455L	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1515					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						GCACCCTTCACGGACTCACAG	0.552000													9	57					2.74318e-10	4.31997e-10	1	1	0
OR6K3	391114	broad.mit.edu	37	1	158687040	158687040	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:158687040T>A	ENST00000368146.1	-	1	913	c.914A>T	c.(913-915)tAt>tTt	p.Y305F	OR6K3_ENST00000368145.1_Missense_Mutation_p.Y289F			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	305					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					TCTCAGGCTATAAATGATGGG	0.418000													25	161					0	0	1	0	0
OR14K1	343170	broad.mit.edu	37	1	247902447	247902447	+	Silent	SNP	C	C	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:247902447C>T	ENST00000283225.2	+	1	531	c.531C>T	c.(529-531)tgC>tgT	p.C177C	RP11-634B7.4_ENST00000449298.1_RNA					olfactory receptor, family 14, subfamily K, member 1											NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|lung(18)|ovary(1)|urinary_tract(1)	27						AGTTCTTCTGCGATGTCCCTG	0.453000													23	217					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160035560	160035560	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr2:160035560C>T	ENST00000263635.6	+	14	2633	c.2396C>T	c.(2395-2397)tCc>tTc	p.S799F	TANC1_ENST00000454300.1_Missense_Mutation_p.S693F	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	799						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						GACGCCCTCTCCTGCTTCCTC	0.562000													22	163					0	0	1	0	0
CNKSR2	22866	broad.mit.edu	37	X	21608721	21608721	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:21608721C>A	ENST00000425654.2	+	13	2030	c.1550C>A	c.(1549-1551)tCa>tAa	p.S517*	CNKSR2_ENST00000485012.1_3'UTR|CNKSR2_ENST00000279451.4_Nonsense_Mutation_p.S547*|CNKSR2_ENST00000543067.1_Nonsense_Mutation_p.S498*|CNKSR2_ENST00000379510.3_Nonsense_Mutation_p.S547*	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	547					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						CAGCACAAATCAAAGAAGAAA	0.398000													5	42					0.184627	0.186492	1	1	0
EIF4G3	8672	broad.mit.edu	37	1	21268711	21268711	+	Silent	SNP	T	T	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:21268711T>A	ENST00000602326.1	-	12	1369	c.786A>T	c.(784-786)atA>atT	p.I262I	EIF4G3_ENST00000374927.4_Silent_p.I256I|EIF4G3_ENST00000374935.3_Intron|EIF4G3_ENST00000374937.3_Silent_p.I262I|EIF4G3_ENST00000536266.1_5'UTR|EIF4G3_ENST00000400422.1_Silent_p.I256I|EIF4G3_ENST00000356916.3_Silent_p.I267I|EIF4G3_ENST00000264211.8_Silent_p.I256I	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	256					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CTATGGATACTATTGCAGTAG	0.483000													13	124					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155215151	155215151	+	Missense_Mutation	SNP	C	C	A	rs149981533		TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr3:155215151C>A	ENST00000460012.1	-	15	2119	c.1762G>T	c.(1762-1764)Gtg>Ttg	p.V588L	PLCH1_ENST00000414191.1_Missense_Mutation_p.V588L|PLCH1_ENST00000494598.1_Missense_Mutation_p.V606L|PLCH1_ENST00000340059.7_Missense_Mutation_p.V606L|PLCH1_ENST00000447496.2_Missense_Mutation_p.V606L|PLCH1_ENST00000334686.6_Missense_Mutation_p.V588L			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	606					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TTTGTGTACACAACCAAATCA	0.453000													9	88					4.68919e-08	6.99879e-08	1	1	0
SIPA1L2	57568	broad.mit.edu	37	1	232650439	232650439	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:232650439C>A	ENST00000366630.1	-	2	1005	c.647G>T	c.(646-648)cGa>cTa	p.R216L	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.R216L			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	216					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				ATTTTCTACTCGGTACCCTCT	0.498000													26	172					7.07758e-08	1.04082e-07	1	1	0
MUC16	94025	broad.mit.edu	37	19	9045880	9045880	+	Silent	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr19:9045880G>T	ENST00000397910.4	-	5	35954	c.35751C>A	c.(35749-35751)tcC>tcA	p.S11917S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11919	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTGTGTTCCAGGAGGTCACAG	0.498000													9	110					0.000442599	0.00051766	1	1	0
ACOX3	8310	broad.mit.edu	37	4	8398716	8398716	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr4:8398716T>A	ENST00000356406.5	-	9	1081	c.1004A>T	c.(1003-1005)cAg>cTg	p.Q335L	ACOX3_ENST00000503233.1_Missense_Mutation_p.Q335L|ACOX3_ENST00000413009.2_Missense_Mutation_p.Q335L	NM_003501.2	NP_003492.2	O15254	ACOX3_HUMAN	acyl-CoA oxidase 3, pristanoyl	335					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(17)|prostate(1)|skin(3)|stomach(1)	42						GGGTCCAAACTGACGCCGAGT	0.537000													10	66					0	0	1	0	0
TST	7263	broad.mit.edu	37	22	37407157	37407157	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr22:37407157C>T	ENST00000403892.3	-	2	1539	c.805G>A	c.(805-807)Gtg>Atg	p.V269M	TST_ENST00000249042.3_Missense_Mutation_p.V269M	NM_001270483.1	NP_001257412.1	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase (rhodanese)	269	Rhodanese 2.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	7						TACACGGCCACATCAGGCTTG	0.647000													8	77					0	0	1	0	0
CDON	50937	broad.mit.edu	37	11	125864182	125864182	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr11:125864182C>A	ENST00000392693.3	-	14	2774	c.2647G>T	c.(2647-2649)Gaa>Taa	p.E883*	CDON_ENST00000263577.7_Nonsense_Mutation_p.E883*|CDON_ENST00000531738.1_Nonsense_Mutation_p.E260*	NM_001243597.1|NM_016952.4	NP_001230526.1|NP_058648.4	Q4KMG0	CDON_HUMAN	cell adhesion associated, oncogene regulated	883	Fibronectin type-III 3.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(9)|ovary(3)|prostate(2)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	61	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		GACTTACCTTCTACAACATCC	0.388000													8	44					0.00307968	0.00347986	1	1	0
OR2G6	391211	broad.mit.edu	37	1	248685229	248685229	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:248685229C>A	ENST00000343414.4	+	1	314	c.282C>A	c.(280-282)taC>taA	p.Y94*		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.Y94Y(1)		NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCATGAGCTACGGTGGCTGTG	0.532000													10	127					0.000673444	0.00076965	1	1	0
ADCK1	57143	broad.mit.edu	37	14	78374163	78374163	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr14:78374163G>T	ENST00000238561.5	+	7	858	c.759G>T	c.(757-759)tgG>tgT	p.W253C	ADCK1_ENST00000341211.5_Missense_Mutation_p.W185C	NM_020421.3	NP_065154.2	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1	260	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(2)	25			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		GAATCCACTGGGACCTGTCCA	0.577000													5	35					0.184627	0.186492	1	1	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414902	14414902	+	RNA	SNP	G	G	A	rs2821609	by1000genomes	TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr21:14414902G>A	ENST00000507941.1	+	0	95																											CCAGCTTGACGTCCTTGATGG	0.443000													4	41					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	133041305	133041305	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr7:133041305G>T	ENST00000253861.4	+	6	1014	c.985G>T	c.(985-987)Gtt>Ttt	p.V329F	EXOC4_ENST00000393161.2_Missense_Mutation_p.V329F|EXOC4_ENST00000539845.1_Missense_Mutation_p.V228F	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	329					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				GGGGGAGAACGTTACTGTGGA	0.463000													4	54					0.00909568	0.0097803	1	1	0
GALNT7	51809	broad.mit.edu	37	4	174169303	174169303	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr4:174169303G>T	ENST00000265000.4	+	2	382	c.299G>T	c.(298-300)gGa>gTa	p.G100V	GALNT7_ENST00000512285.1_Missense_Mutation_p.G100V	NM_017423.2	NP_059119.2	Q86SF2	GALT7_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)	100					protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|liver(1)|lung(9)	19		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		CACCATGCTGGAGGAGATTCC	0.458000													9	56					3.09899e-07	4.39572e-07	1	1	0
ZNF566	84924	broad.mit.edu	37	19	36967454	36967454	+	Silent	SNP	A	A	G			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr19:36967454A>G	ENST00000454319.1	-	2	140	c.6T>C	c.(4-6)gcT>gcC	p.A2A	ZNF566_ENST00000493391.1_5'UTR|ZNF566_ENST00000472909.2_5'UTR|ZNF566_ENST00000424129.2_Silent_p.A2A|ZNF566_ENST00000434377.2_Silent_p.A2A|ZNF566_ENST00000392170.2_Silent_p.A2A	NM_001145343.1|NM_001145344.1|NM_001145345.1	NP_001138815.1|NP_001138816.1|NP_001138817.1	Q969W8	ZN566_HUMAN	zinc finger protein 566	2					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24	Esophageal squamous(110;0.162)					ATCTCACCTGAGCCATGGCTC	0.398000													9	55					0	0	1	0	0
CA5BP1	340591	broad.mit.edu	37	X	15706830	15706830	+	RNA	SNP	C	C	A	rs4060	by1000genomes	TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:15706830C>A	ENST00000380334.2	+	0	74																											GGGGCGATCGCCAGTCACCCA	0.532000													4	59					0.00909568	0.0097803	1	1	0
HECTD4	283450	broad.mit.edu	37	12	112688129	112688129	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr12:112688129T>A	ENST00000550722.1	-	25	3726	c.3331A>T	c.(3331-3333)Agc>Tgc	p.S1111C	HECTD4_ENST00000377560.5_Missense_Mutation_p.S1085C|HECTD4_ENST00000430131.2_Missense_Mutation_p.S835C	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		GGAGAGGGGCTCGGAGTAAGG	0.547000													12	87					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112824042	112824042	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr5:112824042T>C	ENST00000408903.3	-	1	485	c.70A>G	c.(70-72)Agc>Ggc	p.S24G		NM_001085377.1	NP_001078846.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	552					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		ctgctgctgctgccgctgccg	0.731000													3	12					0	0	1	0	0
MSL3	10943	broad.mit.edu	37	X	11778537	11778537	+	Silent	SNP	A	A	G			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:11778537A>G	ENST00000337339.2	+	3	228	c.201A>G	c.(199-201)gcA>gcG	p.A67A	MSL3_ENST00000312196.4_Silent_p.A67A|MSL3_ENST00000398527.2_Silent_p.A55A|MSL3_ENST00000380693.3_5'UTR|MSL3_ENST00000361672.2_5'UTR	NM_078628.1	NP_523352.1	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3 homolog (Drosophila)	67	Chromo.				histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	19						ATAGATGGGCAGCAGAAGATC	0.378000													8	113					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459708	107459708	+	Silent	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr2:107459708C>A	ENST00000409382.3	-	2	1336	c.726G>T	c.(724-726)cgG>cgT	p.R242R	ST6GAL2_ENST00000409087.3_Silent_p.R242R|ST6GAL2_ENST00000361686.4_Silent_p.R242R	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	242					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						GCCCGGCCTCCCGCTTCCCGC	0.682000													3	13					6.4e-05	7.75758e-05	1	1	0
PRLR	5618	broad.mit.edu	37	5	35070364	35070364	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr5:35070364G>T	ENST00000382002.5	-	7	973	c.547C>A	c.(547-549)Cat>Aat	p.H183N	PRLR_ENST00000509934.1_5'UTR|PRLR_ENST00000348262.3_Missense_Mutation_p.H183N|PRLR_ENST00000397391.3_Missense_Mutation_p.H112N|PRLR_ENST00000310101.5_Missense_Mutation_p.H183N|PRLR_ENST00000513753.1_Missense_Mutation_p.H183N|PRLR_ENST00000542609.1_Missense_Mutation_p.H183N|PRLR_ENST00000342362.5_Missense_Mutation_p.H82N|PRLR_ENST00000511486.1_Missense_Mutation_p.H82N|PRLR_ENST00000231423.3_Missense_Mutation_p.H183N	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	183	Fibronectin type-III 2.				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	CCAGCAAAATGGATCTAAGGT	0.398000													9	75					0.000673444	0.00076965	1	1	0
SIM1	6492	broad.mit.edu	37	6	100841683	100841683	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr6:100841683G>T	ENST00000369208.3	-	11	2032	c.1250C>A	c.(1249-1251)cCg>cAg	p.P417Q	SIM1_ENST00000262901.4_Missense_Mutation_p.P417Q			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	417	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CAGAAGCTGCGGAGAGGCCGT	0.587000													6	46					1.6384e-10	2.60063e-10	1	1	0
AQR	9716	broad.mit.edu	37	15	35192938	35192938	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr15:35192938C>A	ENST00000156471.5	-	20	2353	c.2128G>T	c.(2128-2130)Gcc>Tcc	p.A710S		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	710						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		TCAAGGGTGGCAATCTGATTG	0.413000													8	126					1.26484e-09	1.97632e-09	1	1	0
OSM	5008	broad.mit.edu	37	22	30661059	30661059	+	Missense_Mutation	SNP	C	C	A	rs140074040	by1000genomes	TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr22:30661059C>A	ENST00000215781.2	-	2	149	c.109G>T	c.(109-111)Gtg>Ttg	p.V37L	OSM_ENST00000403463.1_Intron|OSM_ENST00000403389.1_Missense_Mutation_p.V16L	NM_020530.4	NP_065391.1	P13725	ONCM_HUMAN	oncostatin M	37					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|skin(3)	11			Epithelial(10;0.206)			CCAAGGAGCACGCGGTACTCT	0.582000													18	175					5.01169e-05	6.14932e-05	1	1	0
TESK1	7016	broad.mit.edu	37	9	35609227	35609227	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr9:35609227C>T	ENST00000336395.5	+	10	1619	c.1369C>T	c.(1369-1371)Cct>Tct	p.P457S	TESK1_ENST00000498522.1_3'UTR	NM_006285.2	NP_006276.2	Q15569	TESK1_HUMAN	testis-specific kinase 1	457					cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	27			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AGGTCCTGGCCCTCCCGCTGT	0.706000													6	86					0	0	1	0	0
DEFB118	117285	broad.mit.edu	37	20	29956509	29956509	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr20:29956509C>G	ENST00000253381.2	+	1	89	c.56C>G	c.(55-57)cCa>cGa	p.P19R		NM_054112.2	NP_473453.1	Q96PH6	DB118_HUMAN	defensin, beta 118	19					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				breast(1)|endometrium(1)|lung(7)|ovary(3)|pancreas(1)|prostate(1)	14	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CAAGTGATCCCAGGTAATCAG	0.498000													7	65					0	0	1	0	0
RASGRP4	115727	broad.mit.edu	37	19	38911777	38911777	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr19:38911777C>A	ENST00000454404.2	-	3	485	c.272G>T	c.(271-273)tGg>tTg	p.W91L	RASGRP4_ENST00000587753.1_Missense_Mutation_p.W91L|RASGRP4_ENST00000587738.1_Missense_Mutation_p.W91L|RASGRP4_ENST00000426920.2_Missense_Mutation_p.W91L|RASGRP4_ENST00000293062.9_Missense_Mutation_p.W91L|RASGRP4_ENST00000433821.2_Missense_Mutation_p.W91L|RASGRP4_ENST00000586305.1_Missense_Mutation_p.W91L	NM_001146205.1|NM_170604.2	NP_001139677.1|NP_733749.1	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4	91	N-terminal Ras-GEF.				activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			cervix(1)|kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|prostate(3)|skin(1)	23	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CGGCAGCACCCAGCTGTGCAT	0.622000													11	72					3.07112e-06	4.04094e-06	1	1	0
TBC1D12	23232	broad.mit.edu	37	10	96271394	96271394	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr10:96271394A>T	ENST00000225235.4	+	9	1854	c.1744A>T	c.(1744-1746)Agg>Tgg	p.R582W	TBC1D12_ENST00000485048.1_3'UTR	NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12	582	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CACATGCTACAGGCCTGATGT	0.323000													27	181					0	0	1	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798280	55798280	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr11:55798280C>G	ENST00000313555.1	+	1	386	c.386C>G	c.(385-387)cCa>cGa	p.P129R		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					ATCTGCAACCCACTGCTCTAT	0.473000													7	107					0	0	1	0	0
TRIM3	10612	broad.mit.edu	37	11	6472274	6472274	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr11:6472274C>T	ENST00000525074.1	-	9	2112	c.1718G>A	c.(1717-1719)gGc>gAc	p.G573D	TRIM3_ENST00000537602.1_Missense_Mutation_p.G495D|TRIM3_ENST00000536344.1_Missense_Mutation_p.G454D|TRIM3_ENST00000359518.3_Missense_Mutation_p.G573D|TRIM3_ENST00000345851.3_Missense_Mutation_p.G573D	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	573					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATGAGGCGGCCAGCTCCAAT	0.517000													7	44					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37482000	37482000	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr10:37482000G>T	ENST00000374660.1	+	32	2809	c.2710G>T	c.(2710-2712)Gat>Tat	p.D904Y	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.D785Y|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.D785Y|ANKRD30A_ENST00000475522.1_3'UTR			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	960						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AGAGTCTCCTGATAATGATGG	0.294000													20	138					3.99206e-14	7.25829e-14	1	1	0
GABARAPL1	23710	broad.mit.edu	37	12	10373180	10373180	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr12:10373180A>T	ENST00000421801.2	+	3	605	c.311A>T	c.(310-312)tAc>tTc	p.Y104F	GABARAPL1_ENST00000544284.1_Intron|GABARAPL1_ENST00000546017.1_Intron|GABARAPL1_ENST00000266458.5_Intron|GABARAPL1_ENST00000545887.1_Intron|GABARAPL1_ENST00000545047.1_3'UTR|GABARAPL1_ENST00000543602.1_Missense_Mutation_p.Y104F|GABARAPL1_ENST00000539170.1_Intron|GABARAPL1_ENST00000535576.1_Intron			Q9H0R8	GBRL1_HUMAN	GABA(A) receptor-associated protein like 1	0						autophagic vacuole|endoplasmic reticulum|Golgi apparatus|membrane|microtubule	beta-tubulin binding|GABA receptor binding			NS(1)|lung(1)	2						GTTGCACAATACTGGATGCCG	0.493000													13	35					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92498130	92498130	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr11:92498130C>A	ENST00000298047.6	+	5	4087	c.4070C>A	c.(4069-4071)cCt>cAt	p.P1357H	FAT3_ENST00000525166.1_Missense_Mutation_p.P1207H|FAT3_ENST00000409404.2_Missense_Mutation_p.P1357H|RP11-203F8.1_ENST00000529884.1_RNA			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1357	Cadherin 12.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCCCCTTCACCTATACCATTG	0.493000										TCGA Ovarian(4;0.039)			5	71					0.000602214	0.000696202	1	1	0
IL1RAPL1	11141	broad.mit.edu	37	X	29973778	29973778	+	Silent	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:29973778C>A	ENST00000378993.1	+	11	2605	c.1932C>A	c.(1930-1932)ggC>ggA	p.G644G	IL1RAPL1_ENST00000302196.4_Silent_p.G644G	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	644	Interaction with NCS1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						CCTCCATAGGCAATCAGCATA	0.507000													5	35					0.000602214	0.000696202	1	1	0
MSL3	10943	broad.mit.edu	37	X	11778536	11778536	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:11778536C>A	ENST00000337339.2	+	3	227	c.200C>A	c.(199-201)gCa>gAa	p.A67E	MSL3_ENST00000312196.4_Missense_Mutation_p.A67E|MSL3_ENST00000398527.2_Missense_Mutation_p.A55E|MSL3_ENST00000380693.3_5'UTR|MSL3_ENST00000361672.2_5'UTR	NM_078628.1	NP_523352.1	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3 homolog (Drosophila)	67	Chromo.				histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	19						GATAGATGGGCAGCAGAAGAT	0.373000													8	113					0.0381472	0.0399447	1	1	0
ZNF154	7710	broad.mit.edu	37	19	58214095	58214095	+	Silent	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr19:58214095G>T	ENST00000512439.2	-	3	418	c.222C>A	c.(220-222)gcC>gcA	p.A74A	AC003006.7_ENST00000599221.1_Intron|AC003006.7_ENST00000596085.1_Intron|ZNF154_ENST00000426889.1_Silent_p.A74A			Q13106	ZN154_HUMAN	zinc finger protein 154	74	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(3)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TCACAAACAAGGCTCTGCCCA	0.478000													10	72					7.48243e-07	1.00435e-06	1	1	0
ZNF546	339327	broad.mit.edu	37	19	40520078	40520078	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr19:40520078T>C	ENST00000347077.4	+	7	1117	c.901T>C	c.(901-903)Tac>Cac	p.Y301H	ZNF546_ENST00000596894.1_Intron|ZNF546_ENST00000600094.1_Missense_Mutation_p.Y275H	NM_178544.3	NP_848639.2	Q86UE3	ZN546_HUMAN	zinc finger protein 546	301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(15)|lung(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	34	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TGTGAAACCCTACGAGTGTAA	0.418000													12	142					0	0	1	0	0
KCNB1	3745	broad.mit.edu	37	20	47990864	47990864	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr20:47990864G>C	ENST00000371741.4	-	2	1399	c.1233C>G	c.(1231-1233)atC>atG	p.I411M		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	411					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TATTGACGATGATGGGGATGG	0.507000													10	82					0	0	1	0	0
SLITRK2	84631	broad.mit.edu	37	X	144906478	144906478	+	Silent	SNP	G	G	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:144906478G>C	ENST00000370490.1	+	1	6790	c.2535G>C	c.(2533-2535)ctG>ctC	p.L845L	SLITRK2_ENST00000434188.2_Silent_p.L845L|SLITRK2_ENST00000413937.2_Silent_p.L845L|SLITRK2_ENST00000428560.2_Silent_p.L845L|SLITRK2_ENST00000447897.2_Silent_p.L845L			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	845						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGTCAGCTGTGAAGGGAAA	0.453000													5	66					0	0	1	0	0
UBR1	197131	broad.mit.edu	37	15	43282228	43282228	+	Splice_Site	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr15:43282228G>A	ENST00000290650.4	-	34	3926	c.3848_splice	c.e34+1	p.S1283_splice	UBR1_ENST00000382177.2_3'UTR	NM_174916.2	NP_777576.1	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin 1	1283					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		AGATACTTACGAAGACTCAAC	0.323000													3	17					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915013	119915013	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr7:119915013C>A	ENST00000331113.4	+	1	1292	c.327C>A	c.(325-327)caC>caA	p.H109Q		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	109					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding	p.H109H(2)		NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					ATCCTCGCCACGAGTGCATCT	0.527000													25	188					7.92952e-12	1.36716e-11	1	1	0
TLR2	7097	broad.mit.edu	37	4	154624528	154624528	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr4:154624528G>T	ENST00000260010.6	+	1	1877	c.469G>T	c.(469-471)Gga>Tga	p.G157*		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	157					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				CCTGAGAGTGGGAAATATGGA	0.368000													8	100					5.18039e-06	6.77175e-06	1	1	0
CIDEB	27141	broad.mit.edu	37	14	24774918	24774918	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr14:24774918A>T	ENST00000336557.5	-	8	1883	c.581T>A	c.(580-582)cTg>cAg	p.L194Q	NOP9_ENST00000267425.3_3'UTR|CIDEB_ENST00000554411.1_Missense_Mutation_p.L194Q|CIDEB_ENST00000556756.1_Missense_Mutation_p.L3Q|CIDEB_ENST00000258807.5_Missense_Mutation_p.L194Q			Q9UHD4	CIDEB_HUMAN	cell death-inducing DFFA-like effector b	194					apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis	cytosol				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|urinary_tract(1)	7				GBM - Glioblastoma multiforme(265;0.0181)		GGAAATTCCCAGCAACATATG	0.567000													5	63					0	0	1	0	0
GLP2R	9340	broad.mit.edu	37	17	9757867	9757867	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr17:9757867C>A	ENST00000262441.5	+	5	1073	c.560C>A	c.(559-561)tCc>tAc	p.S187Y	GLP2R_ENST00000574745.1_Missense_Mutation_p.S7Y	NM_004246.1	NP_004237.1	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor	187					G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				endometrium(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	44					Glucagon recombinant(DB00040)	GTGGGATACTCCTTCTCTCTT	0.522000													25	319					1.64293e-13	2.96024e-13	1	1	0
GRIA3	2892	broad.mit.edu	37	X	122551380	122551380	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:122551380G>T	ENST00000264357.5	+	11	1920	c.1628G>T	c.(1627-1629)gGc>gTc	p.G543V	GRIA3_ENST00000542149.1_Missense_Mutation_p.G543V|GRIA3_ENST00000371251.1_Missense_Mutation_p.G543V|GRIA3_ENST00000541091.1_Missense_Mutation_p.G527V|GRIA3_ENST00000371256.5_Missense_Mutation_p.G543V	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	543					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	TCAAAACCAGGCGTATTCTCA	0.423000													20	291					4.96729e-08	7.35895e-08	1	1	0
OR6K3	391114	broad.mit.edu	37	1	158687666	158687666	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:158687666C>G	ENST00000368146.1	-	1	287	c.288G>C	c.(286-288)aaG>aaC	p.K96N	OR6K3_ENST00000368145.1_Missense_Mutation_p.K80N			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	96					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					TGGAGAGCATCTTGGGAATGG	0.453000													29	236					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1207118	1207118	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr19:1207118C>A	ENST00000326873.7	+	1	1379	c.206C>A	c.(205-207)tCg>tAg	p.S69*	STK11_ENST00000585748.1_Intron	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	69	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(3)|p.S69*(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGCTGGACTCGGAGACGCTG	0.597000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			3	24					0.115264	0.120067	1	1	0
BTK	695	broad.mit.edu	37	X	100612562	100612562	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:100612562G>A	ENST00000308731.7	-	13	1275	c.1112C>T	c.(1111-1113)tCc>tTc	p.S371F	BTK_ENST00000372880.1_Intron	NM_000061.2	NP_000052.1	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	371	SH2.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			breast(4)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(25)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TTTGAGCCTGGATATGAGTCC	0.507000									Agammaglobulinemia, X-linked				18	85					0	0	1	0	0
ATP7A	538	broad.mit.edu	37	X	77264618	77264618	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:77264618C>A	ENST00000341514.6	+	7	1882	c.1727C>A	c.(1726-1728)gCc>gAc	p.A576D	ATP7A_ENST00000350425.4_Intron|ATP7A_ENST00000343533.5_Missense_Mutation_p.A576D	NM_000052.5	NP_000043.3	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	576	HMA 6.				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						ATGACGTGTGCCTCCTGCGTA	0.388000													24	358					2.70639e-06	3.58463e-06	1	1	0
CCT6P1	643253	broad.mit.edu	37	7	65222986	65222986	+	RNA	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr7:65222986G>T	ENST00000442266.1	+	0	578																											GAATTCTGGCGTTTTTTACAA	0.289000													3	14					0.150653	0.154516	1	1	0
TMPRSS4	56649	broad.mit.edu	37	11	117979592	117979592	+	Silent	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr11:117979592G>T	ENST00000534111.1	+	7	823	c.558G>T	c.(556-558)ctG>ctT	p.L186L	TMPRSS4_ENST00000437212.3_Silent_p.L188L|TMPRSS4_ENST00000522307.1_Silent_p.L41L|TMPRSS4_ENST00000523251.1_Silent_p.L148L|TMPRSS4_ENST00000522824.1_Silent_p.L183L	NM_001083947.1|NM_001173551.1|NM_019894.3	NP_001077416.1|NP_001167022.1|NP_063947.1	Q9NRS4	TMPS4_HUMAN	transmembrane protease, serine 4	188	SRCR.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)		CAGGCTCCCTGGTCTCCCTGC	0.577000													11	76					3.86212e-05	4.76805e-05	1	1	0
FLOT2	2319	broad.mit.edu	37	17	27209210	27209210	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr17:27209210C>T	ENST00000394906.2	-	9	867	c.790G>A	c.(790-792)Gac>Aac	p.D264N	FLOT2_ENST00000585169.1_Missense_Mutation_p.D209N|FLOT2_ENST00000394908.4_Missense_Mutation_p.D209N|FLOT2_ENST00000577789.1_5'UTR			Q14254	FLOT2_HUMAN	flotillin 2	209					cell adhesion|epidermis development	cell surface|endocytic vesicle|endosome|membrane fraction				endometrium(3)|lung(6)|prostate(1)|urinary_tract(1)	11	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;3.26e-06)|all cancers(11;1.76e-05)|BRCA - Breast invasive adenocarcinoma(11;0.00015)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			ATCTTGGTGTCTGCCATGAAC	0.527000													8	105					0	0	1	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74914361	74914361	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr11:74914361C>A	ENST00000289575.5	+	13	2233	c.1838C>A	c.(1837-1839)cCc>cAc	p.P613H	SLCO2B1_ENST00000341411.4_Missense_Mutation_p.P386H|SLCO2B1_ENST00000454962.2_Missense_Mutation_p.P386H|SLCO2B1_ENST00000525650.1_Missense_Mutation_p.P469H|SLCO2B1_ENST00000428359.2_Missense_Mutation_p.P591H|SLCO2B1_ENST00000532236.1_Missense_Mutation_p.P497H	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	613					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity	p.P613L(1)		breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	GCCTGGATGCCCAGCCCCGTG	0.637000													16	68					1.02788e-11	1.75707e-11	1	1	0
PIGR	5284	broad.mit.edu	37	1	207106505	207106505	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:207106505C>A	ENST00000356495.4	-	7	1895	c.1712G>T	c.(1711-1713)cGc>cTc	p.R571L		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	571						extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						GCTGACATCGCGGGACCCTGC	0.537000													6	55					5.9392e-07	8.13589e-07	1	1	0
TRIML1	339976	broad.mit.edu	37	4	189068468	189068468	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr4:189068468C>A	ENST00000332517.3	+	6	1489	c.1349C>A	c.(1348-1350)cCa>cAa	p.P450Q	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	450	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CCCTGCCTCCCAAATGAGGGG	0.572000													8	109					0.000157383	0.000187361	1	1	0
DNAJB8	165721	broad.mit.edu	37	3	128181655	128181655	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr3:128181655A>T	ENST00000469083.1	-	2	2991	c.434T>A	c.(433-435)aTg>aAg	p.M145K	DNAJB8_ENST00000319153.3_Missense_Mutation_p.M145K			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	145					protein folding		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		GAAGGCCTCCATGAAGGCCGG	0.622000													6	44					0	0	1	0	0
SERPINB12	89777	broad.mit.edu	37	18	61234132	61234132	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr18:61234132A>T	ENST00000382768.1	+	7	1166	c.1166A>T	c.(1165-1167)gAa>gTa	p.E389V	SERPINB12_ENST00000269491.1_Missense_Mutation_p.E369V			Q96P63	SPB12_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 12	369					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(5)|lung(19)|skin(1)	26						GTTGTCTCGGAAAGGTCACTA	0.453000													12	81					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559037	140559037	+	Silent	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr5:140559037C>A	ENST00000239444.2	+	1	1667	c.1422C>A	c.(1420-1422)gtC>gtA	p.V474V		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		474	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGGCAGCGTCAGCGCCACAG	0.657000													36	383					1.67305e-13	2.98758e-13	1	1	0
CNTNAP2	26047	broad.mit.edu	37	7	146997278	146997278	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr7:146997278C>A	ENST00000361727.3	+	9	1910	c.1394C>A	c.(1393-1395)gCc>gAc	p.A465D		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	465	Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CGCTTCCTAGCCAAGGAAAAT	0.403000										HNSCC(39;0.1)			18	118					1.56452e-12	2.74478e-12	1	1	0
GPR50	9248	broad.mit.edu	37	X	150349475	150349475	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:150349475C>A	ENST00000218316.3	+	2	1489	c.1420C>A	c.(1420-1422)Ccc>Acc	p.P474T		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	474	Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCAGCAACCCCAAGCCCAT	0.552000													30	409					1.12875e-08	1.73654e-08	1	1	0
PRG4	10216	broad.mit.edu	37	1	186269344	186269344	+	Splice_Site	SNP	G	G	T	rs61729243	byFrequency	TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:186269344G>T	ENST00000445192.2	+	3	243	c.199_splice	c.e3+1	p.A66_splice	PRG4_ENST00000367486.3_Splice_Site_p.A66_splice|PRG4_ENST00000367485.4_Splice_Site_p.A66_splice|PRG4_ENST00000367483.4_Intron|PRG4_ENST00000367484.3_Intron	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	66	SMB 1.|SMB 2.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						TCTGCACTGCGGGTAAGTCCT	0.547000													12	130					1.61879e-10	2.60063e-10	1	1	0
USP26	83844	broad.mit.edu	37	X	132159646	132159646	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:132159646G>C	ENST00000511190.1	-	6	3072	c.2603C>G	c.(2602-2604)gCc>gGc	p.A868G	USP26_ENST00000406273.1_Missense_Mutation_p.A868G|USP26_ENST00000370832.1_Missense_Mutation_p.A868G	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	868					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					CTGCATCTGGGCCTCCTGGAT	0.433000													7	127					0	0	1	0	0
CEP128	145508	broad.mit.edu	37	14	81296585	81296585	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr14:81296585C>A	ENST00000216517.6	-	14	1529	c.1252G>T	c.(1252-1254)Gat>Tat	p.D418Y	CEP128_ENST00000555265.1_Intron|CEP128_ENST00000281129.3_Intron			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	818						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						TCTTTACAATCCAAATCTTGA	0.289000													3	6					1	1	1	1	0
CDH6	1004	broad.mit.edu	37	5	31322957	31322957	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr5:31322957C>A	ENST00000265071.2	+	12	2180	c.1915C>A	c.(1915-1917)Cag>Aag	p.Q639K		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	639					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						TCTGAGGCGGCAGCGAAAAAA	0.453000													14	75					1.5739e-10	2.55918e-10	1	1	0
TM9SF4	9777	broad.mit.edu	37	20	30753155	30753155	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr20:30753155G>A	ENST00000217315.5	+	18	2126	c.1786G>A	c.(1786-1788)Gtc>Atc	p.V596I	TM9SF4_ENST00000398022.2_Missense_Mutation_p.V613I			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	613						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGCCCTCATGGTCTTGTCCTT	0.527000													16	110					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85341199	85341199	+	Silent	SNP	C	C	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr15:85341199C>T	ENST00000299927.3	+	3	2521	c.2499C>T	c.(2497-2499)ccC>ccT	p.P833P	ZNF592_ENST00000560079.2_Silent_p.P833P			Q92610	ZN592_HUMAN	zinc finger protein 592	833					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CATTCTGCCCCATGGCCTTCA	0.612000													10	55					0	0	1	0	0
EPN2	22905	broad.mit.edu	37	17	19216559	19216559	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr17:19216559C>T	ENST00000314728.5	+	7	1598	c.1114C>T	c.(1114-1116)Cct>Tct	p.P372S	EPN2_ENST00000395618.3_Missense_Mutation_p.P87S|EPN2_ENST00000395620.2_Missense_Mutation_p.P315S|EPN2_ENST00000347697.2_Missense_Mutation_p.P315S|EPN2_ENST00000575595.1_Missense_Mutation_p.P80S|EPN2_ENST00000571254.1_Missense_Mutation_p.P308S|EPN2_ENST00000395626.1_Missense_Mutation_p.P372S	NM_014964.4	NP_055779.2	O95208	EPN2_HUMAN	epsin 2	372	6 X 3 AA repeats of [DE]-P-W.				endocytosis		lipid binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	19	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					GCCAGCGGCTCCTGCGAGTAC	0.662000													7	67					0	0	1	0	0
FKBP15	23307	broad.mit.edu	37	9	115935780	115935780	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr9:115935780C>T	ENST00000238256.3	-	23	2602	c.2485G>A	c.(2485-2487)Gca>Aca	p.A829T		NM_015258.1	NP_056073.1	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	829					endocytosis|protein folding	axon|early endosome	actin binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(9)|ovary(3)|urinary_tract(1)	26						TCTCTCTGTGCGCACACCTCC	0.488000													6	62					0	0	1	0	0
LIM2	3982	broad.mit.edu	37	19	51890567	51890567	+	Missense_Mutation	SNP	C	C	G	rs142234866		TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr19:51890567C>G	ENST00000221973.3	-	2	173	c.131G>C	c.(130-132)cGg>cCg	p.R44P	LIM2_ENST00000596399.1_Missense_Mutation_p.R44P	NM_030657.3	NP_085915.2	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa	44					cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		CAGGCAGTACCGCCACAGGCC	0.672000													16	85					0	0	1	0	0
HFM1	164045	broad.mit.edu	37	1	91784760	91784760	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:91784760G>A	ENST00000370425.3	-	25	2785	c.2687C>T	c.(2686-2688)tCa>tTa	p.S896L	HFM1_ENST00000462405.1_5'UTR|HFM1_ENST00000370424.3_Missense_Mutation_p.S575L|HFM1_ENST00000294696.5_Missense_Mutation_p.S128L	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	896	SEC63.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TACAAAATCTGACAACCCTAA	0.284000													7	50					0	0	1	0	0
LRRC8B	23507	broad.mit.edu	37	1	90048428	90048428	+	Silent	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:90048428G>A	ENST00000330947.2	+	5	579	c.219G>A	c.(217-219)ctG>ctA	p.L73L	LRRC8B_ENST00000439853.1_Silent_p.L73L|LRRC8B_ENST00000358200.4_Silent_p.L73L	NM_001134476.1	NP_001127948.1	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member B	73						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	26		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		GGGACATCCTGAAAGCCAGCA	0.542000													8	110					0	0	1	0	0
FTMT	94033	broad.mit.edu	37	5	121187742	121187742	+	Silent	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr5:121187742C>A	ENST00000321339.1	+	1	93	c.84C>A	c.(82-84)ctC>ctA	p.L28L		NM_177478.1	NP_803431.1	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial	28					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	33		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		GCTTCGCGCTCCCGCTGCGTT	0.751000													3	22					0.004672	0.00519111	1	1	0
GPR158	57512	broad.mit.edu	37	10	25885645	25885645	+	Missense_Mutation	SNP	G	G	A	rs140090961		TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr10:25885645G>A	ENST00000376351.3	+	10	2431	c.2072G>A	c.(2071-2073)cGa>cAa	p.R691Q	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	691						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GACATGGGCCGATCTGGATCC	0.448000													10	54					0	0	1	0	0
KLHL3	26249	broad.mit.edu	37	5	137028039	137028039	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr5:137028039C>A	ENST00000508657.1	-	5	1079	c.365G>T	c.(364-366)gGc>gTc	p.G122V	KLHL3_ENST00000541417.1_Missense_Mutation_p.A36S|KLHL3_ENST00000309755.4_Missense_Mutation_p.G154V|KLHL3_ENST00000394937.3_Missense_Mutation_p.G154V|KLHL3_ENST00000506491.1_Missense_Mutation_p.G72V	NM_001257194.1	NP_001244123.1	Q9UH77	KLHL3_HUMAN	kelch-like family member 3	154						cytoplasm|cytoskeleton	actin binding|structural molecule activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)	21		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		TGCACGGATGCCCAGGCAATT	0.597000													4	29					1.23904e-05	1.57839e-05	1	1	0
MAGEE1	57692	broad.mit.edu	37	X	75650066	75650066	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:75650066G>C	ENST00000361470.2	+	1	2021	c.1743G>C	c.(1741-1743)atG>atC	p.M581I		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	581	MAGE 1.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						GGCCAAAGATGGGCCTCCTGA	0.512000													5	30					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142572678	142572678	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr7:142572678C>A	ENST00000359396.3	-	10	1510	c.1265G>T	c.(1264-1266)gGg>gTg	p.G422V		NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	422					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					GAATGGGCCCCCAAGGATGGT	0.532000													10	111					5.16669e-11	8.61114e-11	1	1	0
NTNG1	22854	broad.mit.edu	37	1	107867473	107867473	+	Silent	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:107867473G>A	ENST00000370067.1	+	3	1443	c.816G>A	c.(814-816)ggG>ggA	p.G272G	NTNG1_ENST00000370071.2_Silent_p.G272G|NTNG1_ENST00000477948.1_3'UTR|NTNG1_ENST00000370068.1_Silent_p.G272G|NTNG1_ENST00000370072.3_Silent_p.G272G|NTNG1_ENST00000370070.2_Silent_p.G272G|NTNG1_ENST00000370073.2_Silent_p.G272G|NTNG1_ENST00000370074.4_Silent_p.G272G|NTNG1_ENST00000542803.1_Silent_p.G272G|NTNG1_ENST00000370061.3_Silent_p.G272G|NTNG1_ENST00000370065.1_Silent_p.G272G|NTNG1_ENST00000370066.1_Silent_p.G272G			Q9Y2I2	NTNG1_HUMAN	netrin G1	272	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CAGCCGTTGGGGAAATATTTG	0.453000													11	58					0	0	1	0	0
OR13C8	138802	broad.mit.edu	37	9	107331895	107331895	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr9:107331895G>T	ENST00000335040.1	+	1	447	c.447G>T	c.(445-447)tgG>tgT	p.W149C		NM_001004483.1	NP_001004483.1	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C, member 8	149					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|skin(1)	25						CTGGGTCCTGGGTCACTGGGC	0.502000													9	75					0.000442599	0.00051766	1	1	0
CPD	1362	broad.mit.edu	37	17	28788988	28788988	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr17:28788988A>G	ENST00000225719.4	+	19	3800	c.3724A>G	c.(3724-3726)Aca>Gca	p.T1242A	CPD_ENST00000543464.2_Missense_Mutation_p.T995A	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	1242	Carboxypeptidase-like 3.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						AAAGGTACAAACAAAAGAGGG	0.393000													13	83					0	0	1	0	0
STRBP	55342	broad.mit.edu	37	9	125920674	125920674	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr9:125920674G>C	ENST00000447404.2	-	9	1174	c.870C>G	c.(868-870)gaC>gaG	p.D290E	STRBP_ENST00000348403.5_Missense_Mutation_p.D290E|STRBP_ENST00000360998.3_Missense_Mutation_p.D276E			Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	290	DZF.				multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(6)|prostate(1)|skin(2)	26						CATCTGTTGGGTCTCGCTCAC	0.413000													7	70					0	0	1	0	0
GNL3L	54552	broad.mit.edu	37	X	54584913	54584913	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:54584913G>C	ENST00000336470.4	+	15	1630	c.1491G>C	c.(1489-1491)caG>caC	p.Q497H	GNL3L_ENST00000360845.2_Missense_Mutation_p.Q497H	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	497					ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						ACCGTCATCAGATGGGGTGGG	0.522000													14	87					0	0	1	0	0
HERC3	8916	broad.mit.edu	37	4	89602477	89602477	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr4:89602477G>T	ENST00000402738.1	+	21	2746		c.e21+1		HERC3_ENST00000264345.3_Splice_Site|HERC3_ENST00000543130.1_Splice_Site	NM_001271602.1|NM_014606.1	NP_001258531.1|NP_055421.1	Q15034	HERC3_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 3						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|prostate(2)|skin(2)	45				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		CTGAAGGAAGGTACAAAGCTA	0.433000													17	69					1.45105e-14	2.66248e-14	1	1	0
OR6K3	391114	broad.mit.edu	37	1	158687044	158687044	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:158687044T>A	ENST00000368146.1	-	1	909	c.910A>T	c.(910-912)Att>Ttt	p.I304F	OR6K3_ENST00000368145.1_Missense_Mutation_p.I288F			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					AGGCTATAAATGATGGGATTG	0.413000													27	165					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142242938	142242938	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr3:142242938G>T	ENST00000350721.4	-	22	4170	c.4049C>A	c.(4048-4050)gCt>gAt	p.A1350D	ATR_ENST00000383101.3_Missense_Mutation_p.A1286D	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	1350					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						GAGCAACCGAGCTTGAGAGTT	0.408000								Other conserved DNA damage response genes					10	103					1.08611e-07	1.57407e-07	1	1	0
WDR83OS	51398	broad.mit.edu	37	19	12779979	12779979	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr19:12779979A>T	ENST00000596731.1	-	2	2071	c.119T>A	c.(118-120)cTg>cAg	p.L40Q	CTD-2192J16.24_ENST00000597961.1_Missense_Mutation_p.L38Q|WDR83OS_ENST00000222190.5_Missense_Mutation_p.L40Q|WDR83_ENST00000418543.3_Intron	NM_016145.3	NP_057229.1	Q9Y284	CS056_HUMAN	WD repeat domain 83 opposite strand	40						integral to membrane											GATCATGCCCAGCAGGTTCAT	0.632000													4	56					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101436172	101436172	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr12:101436172G>T	ENST00000392979.3	+	11	1336	c.975G>T	c.(973-975)atG>atT	p.M325I	ANO4_ENST00000299222.9_5'UTR|ANO4_ENST00000392977.3_Missense_Mutation_p.M360I	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	360						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						ACACCGGCATGCTCTTCCCAG	0.493000										HNSCC(74;0.22)			9	65					0.00448238	0.00503638	1	1	0
RAB41	347517	broad.mit.edu	37	X	69502667	69502667	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:69502667G>C	ENST00000374473.2	+	3	245	c.199G>C	c.(199-201)Gac>Cac	p.D67H	RAB41_ENST00000276066.4_Missense_Mutation_p.D66H			Q5JT25	RAB41_HUMAN	RAB41, member RAS oncogene family	67					protein transport|small GTPase mediated signal transduction		GTP binding			breast(2)|endometrium(4)|large_intestine(2)|lung(4)|ovary(2)	14						TGTTGGAATTGACTTCTTGTC	0.433000													7	116					0	0	1	0	0
MIR519A2	574500	broad.mit.edu	37	19	54265622	54265622	+	RNA	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr19:54265622G>A	ENST00000384990.1	+	0	25					NR_030222.1																						CCTCTACAGGGAAGCGCTTTC	0.408000													24	162					0	0	1	0	0
METTL21B	25895	broad.mit.edu	37	12	58174040	58174040	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr12:58174040G>T	ENST00000333012.5	+	4	478	c.431G>T	c.(430-432)gGg>gTg	p.G144V	RP11-571M6.15_ENST00000553083.1_Intron|METTL21B_ENST00000551420.1_5'UTR|METTL21B_ENST00000548256.1_Missense_Mutation_p.G102V|RP11-571M6.15_ENST00000471530.1_Intron|METTL21B_ENST00000300209.8_Missense_Mutation_p.G98W	NM_206914.1	NP_996797.1	Q96AZ1	MT21B_HUMAN	methyltransferase like 21B	0						integral to membrane|intracellular	methyltransferase activity			endometrium(1)|lung(1)	2						TCTCTCAGGGGGGGATGTTAC	0.587000													6	34					1.6384e-10	2.60063e-10	1	1	0
NAV1	89796	broad.mit.edu	37	1	201759701	201759701	+	Missense_Mutation	SNP	C	C	A	rs142843126	byFrequency	TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:201759701C>A	ENST00000367296.4	+	12	3659	c.3239C>A	c.(3238-3240)tCt>tAt	p.S1080Y	IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000295624.6_Missense_Mutation_p.S1080Y|NAV1_ENST00000367295.1_Missense_Mutation_p.S689Y|NAV1_ENST00000367302.1_Missense_Mutation_p.S1036Y|NAV1_ENST00000469130.1_Intron|NAV1_ENST00000367300.3_Missense_Mutation_p.S1023Y|NAV1_ENST00000367297.4_Intron	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1080					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						AGGATGCAATCTGAGGTAGGG	0.458000													6	92					3.59834e-05	4.49792e-05	1	1	0
ABCC4	10257	broad.mit.edu	37	13	95847155	95847155	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr13:95847155G>A	ENST00000376887.4	-	9	1312	c.1198C>T	c.(1198-1200)Cgt>Tgt	p.R400C	ABCC4_ENST00000431522.1_Missense_Mutation_p.R400C|ABCC4_ENST00000538287.1_3'UTR|ABCC4_ENST00000536256.1_Missense_Mutation_p.R325C|ABCC4_ENST00000412704.1_Missense_Mutation_p.R400C	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	400					platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	GGCAGCTGACGGTTGCGCTGT	0.378000													8	32					0	0	1	0	0
KCNF1	3754	broad.mit.edu	37	2	11053626	11053626	+	Silent	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr2:11053626C>A	ENST00000295082.1	+	1	1564	c.1074C>A	c.(1072-1074)ccC>ccA	p.P358P		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	358						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		AGAGCATCCCCCAGTCCTTCT	0.592000													5	57					0.184627	0.186492	1	1	0
CCL1	6346	broad.mit.edu	37	17	32688895	32688895	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr17:32688895A>T	ENST00000225842.3	-	2	166	c.97T>A	c.(97-99)Tgt>Agt	p.C33S		NM_002981.1	NP_002972.1	P22362	CCL1_HUMAN	chemokine (C-C motif) ligand 1	33					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity						Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		GAGAAGCAACATCTGGAGAAG	0.438000											OREG0024322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	113					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126389937	126389937	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr4:126389937G>C	ENST00000394329.3	+	11	12183	c.12170G>C	c.(12169-12171)gGa>gCa	p.G4057A	FAT4_ENST00000335110.5_Missense_Mutation_p.G2320A	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4057	Laminin G-like 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GTGTCAGATGGACATTTTCAC	0.368000													22	131					0	0	1	0	0
GYPC	2995	broad.mit.edu	37	2	127453712	127453712	+	Silent	SNP	T	T	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr2:127453712T>C	ENST00000259254.4	+	4	712	c.381T>C	c.(379-381)ttT>ttC	p.F127F	GYPC_ENST00000356887.7_Silent_p.F106F|GYPC_ENST00000464053.1_3'UTR|GYPC_ENST00000409836.3_Silent_p.F108F	NM_002101.4	NP_002092.1	P04921	GLPC_HUMAN	glycophorin C (Gerbich blood group)	127						cortical cytoskeleton|integral to plasma membrane	protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|prostate(2)|urinary_tract(1)	13	Colorectal(110;0.0533)			BRCA - Breast invasive adenocarcinoma(221;0.075)		AGGAGTACTTTATTTGAGGGA	0.547000													8	26					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85634326	85634326	+	Silent	SNP	C	C	G	rs150169644	byFrequency	TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr4:85634326C>G	ENST00000322366.6	-	50	8384	c.7977G>C	c.(7975-7977)acG>acC	p.T2659T	WDFY3_ENST00000295888.4_Silent_p.T2676T			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	2676						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GCTCCACACTCGTGTTTGGTC	0.383000													36	199					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961164	34961164	+	Silent	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:34961164C>A	ENST00000329357.5	+	1	252	c.216C>A	c.(214-216)cgC>cgA	p.R72R		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	72										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						TTGTTTGTCGCCGTGACGAGT	0.532000													5	90					0.014758	0.0157	1	1	0
BRINP3	339479	broad.mit.edu	37	1	190068102	190068102	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:190068102G>T	ENST00000367462.3	-	8	1578	c.1347C>A	c.(1345-1347)tgC>tgA	p.C449*	FAM5C_ENST00000534846.1_Nonsense_Mutation_p.C347*|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		449						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					CGCATGTCAGGCAGGCAGAGG	0.637000													9	81					5.68852e-11	9.40252e-11	1	1	0
PLCB4	5332	broad.mit.edu	37	20	9364878	9364878	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr20:9364878A>T	ENST00000378501.2	+	11	899	c.884A>T	c.(883-885)tAt>tTt	p.Y295F	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000334005.3_Missense_Mutation_p.Y295F|PLCB4_ENST00000278655.4_Missense_Mutation_p.Y295F|PLCB4_ENST00000414679.2_Missense_Mutation_p.Y295F|PLCB4_ENST00000378493.1_Missense_Mutation_p.Y295F|PLCB4_ENST00000378473.3_Missense_Mutation_p.Y295F	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	295					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						TTTTGCAGATATCTGATGTCA	0.408000													23	94					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150947476	150947476	+	Silent	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr5:150947476G>A	ENST00000261800.5	-	1	1029	c.1017C>T	c.(1015-1017)agC>agT	p.S339S		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	339					epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AATAAGGGCCGCTCCCACTCC	0.502000													37	177					0	0	1	0	0
KRT19	3880	broad.mit.edu	37	17	39680656	39680656	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr17:39680656T>C	ENST00000361566.3	-	4	857	c.797A>G	c.(796-798)gAt>gGt	p.D266G		NM_002276.4	NP_002267.2			keratin 19											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	12		Breast(137;0.00038)				GGCTTCAGCATCCTTCCGGTT	0.592000													12	121					0	0	1	0	0
RLF	6018	broad.mit.edu	37	1	40661420	40661420	+	Silent	SNP	A	A	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:40661420A>C	ENST00000372771.4	+	4	618	c.591A>C	c.(589-591)ccA>ccC	p.P197P		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	197					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			CTCAACAGCCAGTAGAAACGG	0.353000													13	70					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35876376	35876376	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr5:35876376T>A	ENST00000303115.3	+	8	1297	c.1168T>A	c.(1168-1170)Tgc>Agc	p.C390S	IL7R_ENST00000343305.4_3'UTR	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	390					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GTCCCTAGACTGCAGGGAGAG	0.542000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						6	53					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228467095	228467095	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:228467095T>C	ENST00000570156.2	+	32	8707	c.8633T>C	c.(8632-8634)gTg>gCg	p.V2878A	OBSCN_ENST00000359599.6_Missense_Mutation_p.V1296A|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000284548.11_Missense_Mutation_p.V2449A|OBSCN_ENST00000422127.1_Missense_Mutation_p.V2449A|OBSCN_ENST00000366707.4_5'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1878	Ig-like 28.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				ACCGGGCCCGTGCACTTCACC	0.692000													4	46					0	0	1	0	0
ZNF566	84924	broad.mit.edu	37	19	36967453	36967453	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr19:36967453G>A	ENST00000454319.1	-	2	141	c.7C>T	c.(7-9)Cag>Tag	p.Q3*	ZNF566_ENST00000493391.1_5'UTR|ZNF566_ENST00000472909.2_5'UTR|ZNF566_ENST00000424129.2_Nonsense_Mutation_p.Q3*|ZNF566_ENST00000434377.2_Nonsense_Mutation_p.Q3*|ZNF566_ENST00000392170.2_Nonsense_Mutation_p.Q3*	NM_001145343.1|NM_001145344.1|NM_001145345.1	NP_001138815.1|NP_001138816.1|NP_001138817.1	Q969W8	ZN566_HUMAN	zinc finger protein 566	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.Q3*(2)		breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24	Esophageal squamous(110;0.162)					TATCTCACCTGAGCCATGGCT	0.398000													10	55					0	0	1	0	0
TIMM8A	1678	broad.mit.edu	37	X	100603638	100603638	+	Silent	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:100603638G>A	ENST00000372902.3	-	1	546	c.15C>T	c.(13-15)tcC>tcT	p.S5S	TIMM8A_ENST00000480575.1_5'UTR	NM_004085.3	NP_004076.1	O60220	TIM8A_HUMAN	translocase of inner mitochondrial membrane 8 homolog A (yeast)	5					nervous system development|protein import into mitochondrial inner membrane|transmembrane transport	mitochondrial inner membrane|mitochondrial intermembrane space protein transporter complex	protein binding			endometrium(1)|lung(1)	2						CGGAGGAAGAGGAGGAGGAAT	0.607000													6	103					0	0	1	0	0
SACM1L	22908	broad.mit.edu	37	3	45776857	45776857	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr3:45776857C>T	ENST00000389061.5	+	14	1435	c.1231C>T	c.(1231-1233)Caa>Taa	p.Q411*	SACM1L_ENST00000541314.1_Nonsense_Mutation_p.Q350*|SACM1L_ENST00000418611.1_Nonsense_Mutation_p.Q308*	NM_014016.3	NP_054735.3	Q9NTJ5	SAC1_HUMAN	SAC1 suppressor of actin mutations 1-like (yeast)	411	SAC.					Golgi apparatus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		ACTTCAGGCCCAACTTCAGGT	0.383000													5	74					0	0	1	0	0
OPTC	26254	broad.mit.edu	37	1	203472699	203472699	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:203472699C>A	ENST00000367222.2	+	7	966	c.850C>A	c.(850-852)Cag>Aag	p.Q284K		NM_014359.3	NP_055174.1	Q9UBM4	OPT_HUMAN	opticin	284						proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			breast(1)|cervix(1)|kidney(5)|large_intestine(3)|lung(8)|pancreas(1)|stomach(1)	20			BRCA - Breast invasive adenocarcinoma(75;0.109)			AGAGACCATGCAGAGAGACGT	0.562000													6	106					0.0381472	0.0399447	1	1	0
OR2L2	26246	broad.mit.edu	37	1	248202038	248202038	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:248202038G>T	ENST00000366479.2	+	1	565	c.469G>T	c.(469-471)Gct>Tct	p.A157S	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CAACTCTTGTGCTCACACAGT	0.433000													33	232					3.90053e-15	7.2232e-15	1	1	0
MUC16	94025	broad.mit.edu	37	19	9077796	9077796	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr19:9077796C>A	ENST00000397910.4	-	3	9853	c.9650G>T	c.(9649-9651)aGc>aTc	p.S3217I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3218	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GATCTCTGGGCTGATGCTGGG	0.488000													19	129					3.8784e-16	7.31774e-16	1	1	0
PLXNA3	55558	broad.mit.edu	37	X	153690500	153690500	+	Silent	SNP	G	G	A	rs139573527	byFrequency	TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chrX:153690500G>A	ENST00000369682.3	+	4	1342	c.1167G>A	c.(1165-1167)ctG>ctA	p.L389L		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	389	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCTGTGGGCTGGTGTTGAACC	0.637000													5	71					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25339257	25339257	+	RNA	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr15:25339257C>A	ENST00000546682.1	+	0	1110				SNHG14_ENST00000553108.1_RNA|SNORD116-24_ENST00000384549.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						ATACCGTCATCTTCGTTGAAC	0.433000													27	192					3.65163e-15	6.82547e-15	1	1	0
APOB	338	broad.mit.edu	37	2	21229787	21229787	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr2:21229787G>T	ENST00000233242.1	-	26	10080	c.9953C>A	c.(9952-9954)cCa>cAa	p.P3318Q		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3318					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTTGAAATCTGGAAGAGAAAG	0.403000													23	113					4.54149e-19	8.65045e-19	1	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84705711	84705711	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr15:84705711G>T	ENST00000286744.5	+	29	5165	c.4941G>T	c.(4939-4941)tgG>tgT	p.W1647C	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.W1647C	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1647						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			CAATTTCCTGGCGGCACTGTC	0.527000													9	38					0.00829132	0.00906155	1	1	0
AGAP10	728127	broad.mit.edu	37	10	47207828	47207828	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr10:47207828C>A	ENST00000355232.3	-	5	3467	c.455G>T	c.(454-456)aGc>aTc	p.S152I	RP11-144G6.12_ENST00000605970.1_RNA|AGAP10_ENST00000413193.2_Missense_Mutation_p.S223I|AGAP10_ENST00000452145.2_Missense_Mutation_p.S127I					ArfGAP with GTPase domain, ankyrin repeat and PH domain 10									p.S223I(4)		endometrium(5)|kidney(3)|lung(1)|prostate(2)|urinary_tract(1)	12						TGTACAGTTGCTTCTTCTTAT	0.264000													4	41					0.00909568	0.0097803	1	1	0
TAS1R2	80834	broad.mit.edu	37	1	19168283	19168283	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:19168283G>T	ENST00000375371.3	-	5	1552	c.1531C>A	c.(1531-1533)Cac>Aac	p.H511N		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	511					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CAGCAGACGTGGATGCCCACA	0.577000													9	76					7.48243e-07	1.00435e-06	1	1	0
ZCWPW1	55063	broad.mit.edu	37	7	100013643	100013643	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr7:100013643G>A	ENST00000398027.2	-	8	953	c.706C>T	c.(706-708)Cat>Tat	p.H236Y	ZCWPW1_ENST00000360951.4_Missense_Mutation_p.H237Y|ZCWPW1_ENST00000324725.6_Missense_Mutation_p.H116Y|ZCWPW1_ENST00000490721.1_Missense_Mutation_p.H116Y	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	236							zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ATCTGAGAATGATCCTGAACT	0.428000													17	184					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156816444	156816444	+	Silent	SNP	C	C	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:156816444C>A	ENST00000368195.3	-	8	2073	c.1677G>T	c.(1675-1677)ggG>ggT	p.G559G	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	559	Fibronectin type-III 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTAGGGTCACCCCTGGCTCCT	0.612000													7	51					2.0095e-06	2.67933e-06	1	1	0
CROCC	9696	broad.mit.edu	37	1	17185383	17185384	+	RNA	INS	-	-	C	rs33920141	by1000genomes	TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr1:17185383_17185384insC	ENST00000414128.1	+	0	646																											ACTAAATTTTTAGTGCAATAAT	0.465													2	4	---	---	---	---					
COL6A3	1293	broad.mit.edu	37	2	238289948	238289949	+	Frame_Shift_Ins	INS	-	-	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr2:238289948_238289949insA	ENST00000295550.4	-	5	1958_1959	c.1506_1507insT	c.(1504-1509)cacaacfs	p.N503fs	COL6A3_ENST00000346358.4_Frame_Shift_Ins_p.N503fs|COL6A3_ENST00000409809.1_Frame_Shift_Ins_p.N297fs|COL6A3_ENST00000472056.1_Frame_Shift_Ins_p.N96fs|COL6A3_ENST00000392004.3_Frame_Shift_Ins_p.N297fs|COL6A3_ENST00000392003.2_Frame_Shift_Ins_p.N96fs|COL6A3_ENST00000353578.4_Frame_Shift_Ins_p.N297fs|COL6A3_ENST00000347401.3_Frame_Shift_Ins_p.N302fs	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	503	Nonhelical region.|VWFA 3.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTTTTTGTTGGATGGGTATTGA	0.505													27	150	---	---	---	---					
PCDHB5	26167	broad.mit.edu	37	5	140515722	140515722	+	Frame_Shift_Del	DEL	A	A	-			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr5:140515722delA	ENST00000231134.5	+	1	923	c.706delA	c.(706-708)atfs	p.N236fs		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		236	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTGGATAATAATGACAACGC	0.537													48	279	---	---	---	---					
ADAM2	2515	broad.mit.edu	37	8	39618747	39618747	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr8:39618747delC	ENST00000265708.4	-	15	1664	c.1561delG	c.(1561-1563)tafs	p.V521fs	ADAM2_ENST00000347580.4_Frame_Shift_Del_p.V502fs|ADAM2_ENST00000379853.2_Frame_Shift_Del_p.V395fs|ADAM2_ENST00000521880.1_Frame_Shift_Del_p.V521fs	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	521	Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TTTCCAGATACATCAGTCTTT	0.318													7	116	---	---	---	---					
CRH	1392	broad.mit.edu	37	8	67089559	67089561	+	In_Frame_Del	DEL	GCG	GCG	-			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr8:67089559_67089561delGCG	ENST00000276571.3	-	2	598_600	c.152_154delCGC	c.(151-156)cag>c	p.PQ51del		NM_000756.2	NP_000747.1	P06850	CRF_HUMAN	corticotropin releasing hormone	51					female pregnancy|negative regulation of circadian sleep/wake cycle, REM sleep|parturition|positive regulation of circadian sleep/wake cycle, wakefulness|positive regulation of cortisol secretion|signal transduction|synaptic transmission	extracellular region|soluble fraction	neuropeptide hormone activity			breast(1)|endometrium(1)|lung(2)|urinary_tract(1)	5		all_cancers(86;2.58e-06)|all_epithelial(80;6.27e-09)|all_lung(136;0.000414)|Lung NSC(129;0.0011)	Epithelial(68;0.0136)|all cancers(69;0.0507)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)		Corticotropin(DB01285)	TGCTCGGACTGCGGCGGCGGCTG	0.734											OREG0018805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
PRB2	653247	broad.mit.edu	37	12	11546831	11546832	+	Frame_Shift_Ins	INS	-	-	A			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr12:11546831_11546832insA	ENST00000389362.4	-	3	215_216	c.180_181insT	c.(178-183)ccccccfs	p.PP60fs	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			CCTTGTGGGGGTGGTCCTTGTG	0.584													151	419	---	---	---	---					
BCL11B	64919	broad.mit.edu	37	14	99641544	99641546	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr14:99641544_99641546delCTC	ENST00000345514.2	-	3	1680_1682	c.1414_1416delGAG	c.(1414-1416)del	p.E472del	BCL11B_ENST00000443726.2_In_Frame_Del_p.E349del|BCL11B_ENST00000357195.3_In_Frame_Del_p.E543del	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	543						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CCAGTAGCAGctcctcctcctcc	0.700			T	TLX3	T-ALL								2	4	---	---	---	---					
TICRR	90381	broad.mit.edu	37	15	90126152	90126152	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr15:90126152delC	ENST00000268138.7	+	2	995	c.890delC	c.(889-891)gcfs	p.A297fs	TICRR_ENST00000560985.1_Frame_Shift_Del_p.A297fs|RP11-429B14.1_ENST00000559041.1_RNA					TOPBP1-interacting checkpoint and replication regulator																		GAGTATGAGGCCTCGTTTCCA	0.358													22	105	---	---	---	---					
LRRC37A11P	342666	broad.mit.edu	37	17	37196001	37196002	+	RNA	DEL	AG	AG	-	rs34712077		TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr17:37196001_37196002delAG	ENST00000425901.2	+	0	2604					NR_033753.2																						GAATACAGACAGAAAAGAATTT	0.327													4	2	---	---	---	---					
TBC1D3P1-DHX40P1	653645	broad.mit.edu	37	17	58090681	58090682	+	RNA	DEL	TT	TT	-			TCGA-NJ-A55O-01A-11D-A25L-08	TCGA-NJ-A55O-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7F2249D6-3A40-444B-9DFD-50B2AE21EE71	F6915BCD-2DD4-49F4-A6BF-29217410DC90	g.chr17:58090681_58090682delTT	ENST00000407042.3	-	0	609																											CTCTGAATGATTTTTTTTTTTT	0.455													3	3	---	---	---	---