Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
ACOT7	11332	broad.mit.edu	37	1	6354951	6354951	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:6354951T>C	uc001ams.2	-	7	989	c.832A>G	c.(832-834)ATT>GTT	p.I278V	ACOT7_uc010nzq.1_Missense_Mutation_p.I163V|ACOT7_uc001amt.2_Missense_Mutation_p.I268V|ACOT7_uc001amu.2_RNA|ACOT7_uc001amv.2_RNA|ACOT7_uc001amq.2_Missense_Mutation_p.I227V|ACOT7_uc001amr.2_Missense_Mutation_p.I248V	NM_181864	NP_863654	O00154	BACH_HUMAN	acyl-CoA thioesterase 7 isoform hBACHb	278	Acyl coenzyme A hydrolase 2.					mitochondrion|nucleus	carboxylesterase activity|fatty-acyl-CoA binding|palmitoyl-CoA hydrolase activity				0	Ovarian(185;0.0634)|all_lung(157;0.175)	all_cancers(23;1.42e-38)|all_epithelial(116;3.96e-23)|all_lung(118;3.69e-08)|Lung NSC(185;8.52e-07)|all_hematologic(16;6.92e-06)|Colorectal(325;4.53e-05)|Acute lymphoblastic leukemia(12;5e-05)|all_neural(13;0.000164)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;9.16e-37)|GBM - Glioblastoma multiforme(13;5.89e-29)|OV - Ovarian serous cystadenocarcinoma(86;7.63e-19)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;2.06e-05)|Kidney(185;7.74e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00129)|BRCA - Breast invasive adenocarcinoma(365;0.00132)|STAD - Stomach adenocarcinoma(132;0.00195)|READ - Rectum adenocarcinoma(331;0.0481)		TGAAAATTAATGGCGTCCACG	0.542													9	37	---	---	---	---	PASS
ACOT7	11332	broad.mit.edu	37	1	6409851	6409851	+	Silent	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:6409851T>A	uc001ams.2	-	2	406	c.249A>T	c.(247-249)GCA>GCT	p.A83A	ACOT7_uc010nzq.1_Intron|ACOT7_uc001amt.2_Silent_p.A73A|ACOT7_uc001amu.2_RNA|ACOT7_uc001amv.2_RNA|ACOT7_uc001amq.2_Silent_p.A32A|ACOT7_uc001amr.2_Silent_p.A53A	NM_181864	NP_863654	O00154	BACH_HUMAN	acyl-CoA thioesterase 7 isoform hBACHb	83	Acyl coenzyme A hydrolase 1.					mitochondrion|nucleus	carboxylesterase activity|fatty-acyl-CoA binding|palmitoyl-CoA hydrolase activity				0	Ovarian(185;0.0634)|all_lung(157;0.175)	all_cancers(23;1.42e-38)|all_epithelial(116;3.96e-23)|all_lung(118;3.69e-08)|Lung NSC(185;8.52e-07)|all_hematologic(16;6.92e-06)|Colorectal(325;4.53e-05)|Acute lymphoblastic leukemia(12;5e-05)|all_neural(13;0.000164)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;9.16e-37)|GBM - Glioblastoma multiforme(13;5.89e-29)|OV - Ovarian serous cystadenocarcinoma(86;7.63e-19)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;2.06e-05)|Kidney(185;7.74e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00129)|BRCA - Breast invasive adenocarcinoma(365;0.00132)|STAD - Stomach adenocarcinoma(132;0.00195)|READ - Rectum adenocarcinoma(331;0.0481)		TGATGGCGCCTGCCTCCTCGA	0.622													10	17	---	---	---	---	PASS
LUZP1	7798	broad.mit.edu	37	1	23418882	23418882	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:23418882C>G	uc001bgk.2	-	4	2257	c.1873G>C	c.(1873-1875)GAA>CAA	p.E625Q	LUZP1_uc010odv.1_Missense_Mutation_p.E625Q|LUZP1_uc001bgl.2_Missense_Mutation_p.E625Q|LUZP1_uc001bgm.1_Missense_Mutation_p.E625Q	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	625						nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		TTAACCCCTTCTTTATGTGAG	0.468													34	115	---	---	---	---	PASS
CSMD2	114784	broad.mit.edu	37	1	34158623	34158623	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:34158623G>A	uc001bxn.1	-	25	3868	c.3839C>T	c.(3838-3840)TCG>TTG	p.S1280L	CSMD2_uc001bxm.1_Missense_Mutation_p.S1320L|CSMD2_uc001bxo.1_Missense_Mutation_p.S193L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1280	CUB 8.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CACCTGCCCCGACACCTCTCC	0.572													61	67	---	---	---	---	PASS
DLGAP3	58512	broad.mit.edu	37	1	35351752	35351752	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:35351752G>A	uc001byc.2	-	4	1521	c.1521C>T	c.(1519-1521)ATC>ATT	p.I507I		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	507					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				AGCCGGCCTGGATGGCCCGGA	0.692													5	5	---	---	---	---	PASS
CSF3R	1441	broad.mit.edu	37	1	36933539	36933539	+	Missense_Mutation	SNP	C	A	A	rs148104401	byFrequency	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:36933539C>A	uc001caw.1	-	14	1926	c.1748G>T	c.(1747-1749)CGT>CTT	p.R583L	CSF3R_uc001cat.1_Missense_Mutation_p.R146L|CSF3R_uc009vvc.1_Missense_Mutation_p.R112L|CSF3R_uc001cau.1_5'UTR|CSF3R_uc001cav.1_Missense_Mutation_p.R583L|CSF3R_uc001cax.1_Missense_Mutation_p.R583L|CSF3R_uc001cay.1_Missense_Mutation_p.R583L	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	583	Fibronectin type-III 5.|Extracellular (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	GACAAAGCCACGGGAGGAGGC	0.637													11	13	---	---	---	---	PASS
ZC3H12A	80149	broad.mit.edu	37	1	37947224	37947224	+	Silent	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:37947224G>T	uc001cbb.3	+	4	756	c.606G>T	c.(604-606)CTG>CTT	p.L202L	ZC3H12A_uc001cbc.1_5'UTR	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	202					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGCGGGAACTGGAGAAGAAGA	0.597													5	80	---	---	---	---	PASS
MACF1	23499	broad.mit.edu	37	1	39833823	39833823	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:39833823C>T	uc010oiu.1	+	14	8226	c.8095C>T	c.(8095-8097)CTC>TTC	p.L2699F	MACF1_uc010ois.1_Missense_Mutation_p.L2197F|MACF1_uc001cda.1_Missense_Mutation_p.L2105F|MACF1_uc001cdc.1_Missense_Mutation_p.L1284F|MACF1_uc001cdb.1_Missense_Mutation_p.L1284F	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4264	LRR 15.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTGACAGGAGCTCAATTTGGA	0.423													13	33	---	---	---	---	PASS
LEPR	3953	broad.mit.edu	37	1	66067350	66067350	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:66067350G>T	uc001dci.2	+	9	1472	c.1270G>T	c.(1270-1272)GAA>TAA	p.E424*	LEPR_uc001dcg.2_Nonsense_Mutation_p.E424*|LEPR_uc001dch.2_Nonsense_Mutation_p.E424*|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Nonsense_Mutation_p.E424*|LEPR_uc001dck.2_Nonsense_Mutation_p.E424*	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	424	Extracellular (Potential).|Ig-like.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TCGCTATGCTGAATTATATGT	0.353													7	11	---	---	---	---	PASS
MSH4	4438	broad.mit.edu	37	1	76342658	76342658	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:76342658C>A	uc001dhd.1	+	10	1384	c.1343C>A	c.(1342-1344)GCT>GAT	p.A448D		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	448					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						TTATTAAGAGCTTACTATGGT	0.279								MMR					8	19	---	---	---	---	PASS
PRKACB	5567	broad.mit.edu	37	1	84663425	84663425	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:84663425G>T	uc001djj.2	+	7	824	c.560G>T	c.(559-561)GGG>GTG	p.G187V	PRKACB_uc001djl.2_Missense_Mutation_p.G234V|PRKACB_uc010ort.1_Missense_Mutation_p.G194V|PRKACB_uc001djn.2_Missense_Mutation_p.G191V|PRKACB_uc010oru.1_Missense_Mutation_p.G175V|PRKACB_uc001djp.2_Missense_Mutation_p.G193V|PRKACB_uc001djq.2_Missense_Mutation_p.G157V|PRKACB_uc010orv.1_Missense_Mutation_p.G174V|PRKACB_uc001dji.2_Missense_Mutation_p.G187V|PRKACB_uc001djk.2_Missense_Mutation_p.G234V|PRKACB_uc009wcf.1_Missense_Mutation_p.G193V	NM_002731	NP_002722	P22694	KAPCB_HUMAN	cAMP-dependent protein kinase catalytic subunit	187	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|regulation of insulin secretion|synaptic transmission|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|magnesium ion binding|protein binding			lung(2)|ovary(1)	3				all cancers(265;0.00536)|Epithelial(280;0.0161)|OV - Ovarian serous cystadenocarcinoma(397;0.141)		ACAGACTTTGGGTTTGCCAAA	0.318													5	32	---	---	---	---	PASS
LRRC8D	55144	broad.mit.edu	37	1	90400188	90400188	+	Missense_Mutation	SNP	T	C	C	rs112842021		TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:90400188T>C	uc001dnm.2	+	3	1986	c.1561T>C	c.(1561-1563)TGC>CGC	p.C521R	LRRC8D_uc001dnn.2_Missense_Mutation_p.C521R	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	521	LRR 1.					integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		GCTCCACCTCTGCCACTGCCC	0.453													36	53	---	---	---	---	PASS
PIAS3	10401	broad.mit.edu	37	1	145580518	145580518	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:145580518C>G	uc001eoc.1	+	7	909	c.818C>G	c.(817-819)TCT>TGT	p.S273C	NBPF10_uc001emp.3_Intron|PIAS3_uc010oyy.1_3'UTR|PIAS3_uc001eod.1_5'UTR	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	273	PINIT.				positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TACTCCTTGTCTGTGTACCTG	0.512													31	43	---	---	---	---	PASS
HIST2H2BE	8349	broad.mit.edu	37	1	149858024	149858024	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:149858024G>T	uc001etc.2	-	1	209	c.167C>A	c.(166-168)TCG>TAG	p.S56*	HIST2H2AC_uc001etd.2_5'Flank	NM_003528	NP_003519	Q16778	H2B2E_HUMAN	histone cluster 2, H2be	56					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GGCCTTGGACGAGATGCCGGT	0.592													6	196	---	---	---	---	PASS
SELENBP1	8991	broad.mit.edu	37	1	151337409	151337409	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:151337409G>C	uc001exx.2	-	11	1296	c.1249C>G	c.(1249-1251)CTC>GTC	p.L417V	SELENBP1_uc010pcy.1_Missense_Mutation_p.L459V|SELENBP1_uc001exy.2_Missense_Mutation_p.L314V|SELENBP1_uc001exz.2_Missense_Mutation_p.L314V|SELENBP1_uc010pcz.1_Missense_Mutation_p.L355V|SELENBP1_uc009wms.2_Missense_Mutation_p.L253V|SELENBP1_uc009wmt.2_Missense_Mutation_p.L314V|SELENBP1_uc001eya.2_Missense_Mutation_p.L353V|SELENBP1_uc009wmu.2_3'UTR	NM_003944	NP_003935	Q13228	SBP1_HUMAN	selenium binding protein 1	417					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding				0	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CACCTGATGAGATCAGGGTAA	0.572													4	23	---	---	---	---	PASS
BCAN	63827	broad.mit.edu	37	1	156626131	156626131	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:156626131G>T	uc001fpp.2	+	9	2336	c.2000G>T	c.(1999-2001)GGG>GTG	p.G667V		NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	667	EGF-like.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GAGGAGGAAGGGGTCCGCTGC	0.642													31	33	---	---	---	---	PASS
FCRL3	115352	broad.mit.edu	37	1	157650786	157650786	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:157650786G>A	uc001frb.2	-	12	2234	c.1942C>T	c.(1942-1944)CCA>TCA	p.P648S	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.P648S|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Missense_Mutation_p.P374S|FCRL3_uc001frc.1_Missense_Mutation_p.P648S	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	648	ITIM motif 1.|Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					CTGTACATTGGCTCCAGCTCC	0.587													4	49	---	---	---	---	PASS
FCRL1	115350	broad.mit.edu	37	1	157773754	157773754	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:157773754C>A	uc001frg.2	-	3	313	c.200G>T	c.(199-201)AGC>ATC	p.S67I	FCRL1_uc001frf.2_5'Flank|FCRL1_uc001frh.2_Missense_Mutation_p.S67I|FCRL1_uc001fri.2_Missense_Mutation_p.S67I|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	67	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CTTGGGGGAGCTGCTCCAGCC	0.562													35	34	---	---	---	---	PASS
APCS	325	broad.mit.edu	37	1	159557995	159557995	+	Silent	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:159557995C>A	uc001ftv.2	+	2	265	c.169C>A	c.(169-171)CGA>AGA	p.R57R		NM_001639	NP_001630	P02743	SAMP_HUMAN	serum amyloid P component precursor	57	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			ovary(1)|breast(1)	2	all_hematologic(112;0.0429)					CTTGTGTTTTCGAGCCTATAG	0.428													4	68	---	---	---	---	PASS
CCDC19	25790	broad.mit.edu	37	1	159856431	159856431	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:159856431C>T	uc001fui.2	-	6	655	c.637G>A	c.(637-639)GAG>AAG	p.E213K	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Missense_Mutation_p.E128K|CCDC19_uc001ful.2_Missense_Mutation_p.E128K|CCDC19_uc009wtc.1_Missense_Mutation_p.E213K	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	213	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			TGCTGCTTCTCCAGGATTTGG	0.478													9	257	---	---	---	---	PASS
HSPA6	3310	broad.mit.edu	37	1	161495234	161495234	+	Silent	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:161495234G>T	uc001gap.2	+	2	1446	c.786G>T	c.(784-786)CTG>CTT	p.L262L	HSPA6_uc001gaq.2_Silent_p.L262L	NM_002155	NP_002146	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	262					response to unfolded protein		ATP binding			skin(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			AGCGTGCCCTGCGCAGGCTGC	0.632													7	9	---	---	---	---	PASS
KIFAP3	22920	broad.mit.edu	37	1	169993642	169993642	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:169993642C>G	uc001ggv.2	-	9	1208	c.937G>C	c.(937-939)GAT>CAT	p.D313H	KIFAP3_uc010plx.1_Missense_Mutation_p.D15H	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	313					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTGTCCCGATCAAGGGCTTTC	0.358													5	25	---	---	---	---	PASS
MYOC	4653	broad.mit.edu	37	1	171605340	171605340	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:171605340C>T	uc001ghu.2	-	3	1262	c.1240G>A	c.(1240-1242)GAA>AAA	p.E414K	MYOC_uc010pmk.1_Missense_Mutation_p.E356K	NM_000261	NP_000252	Q99972	MYOC_HUMAN	myocilin precursor	414	Olfactomedin-like.		E -> K.		anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			lung(1)	1	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					CAGGTTTGTTCGAGTTCCAGA	0.527													35	87	---	---	---	---	PASS
METTL13	51603	broad.mit.edu	37	1	171753518	171753518	+	Missense_Mutation	SNP	G	T	T	rs149343407	byFrequency	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:171753518G>T	uc001ghz.2	+	2	1139	c.792G>T	c.(790-792)AGG>AGT	p.R264S	METTL13_uc001gia.2_Missense_Mutation_p.R178S|METTL13_uc001gib.2_Intron|METTL13_uc010pml.1_Missense_Mutation_p.R263S	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	264							methyltransferase activity|protein binding			kidney(1)	1						GCAAGGCCAGGCTGGGGAGTG	0.677													7	21	---	---	---	---	PASS
TNN	63923	broad.mit.edu	37	1	175052998	175052998	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:175052998C>T	uc001gkl.1	+	5	1274	c.1161C>T	c.(1159-1161)CCC>CCT	p.P387P	TNN_uc010pmx.1_Silent_p.P387P	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	387	Fibronectin type-III 2.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GATATGGCCCCATGACAGGAC	0.537													24	39	---	---	---	---	PASS
TNR	7143	broad.mit.edu	37	1	175372563	175372563	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:175372563C>T	uc001gkp.1	-	2	770	c.689G>A	c.(688-690)TGT>TAT	p.C230Y	TNR_uc009wwu.1_Missense_Mutation_p.C230Y|TNR_uc010pmz.1_Missense_Mutation_p.C230Y	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	230	Cys-rich.|EGF-like 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GAGTTCGGAACAGTCATCCCC	0.632													38	78	---	---	---	---	PASS
ABL2	27	broad.mit.edu	37	1	179078459	179078459	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:179078459C>A	uc001gmj.3	-	12	2230	c.1943G>T	c.(1942-1944)AGG>ATG	p.R648M	ABL2_uc010pnf.1_Missense_Mutation_p.R648M|ABL2_uc010png.1_Missense_Mutation_p.R627M|ABL2_uc010pnh.1_Missense_Mutation_p.R627M|ABL2_uc001gmg.3_Missense_Mutation_p.R633M|ABL2_uc001gmi.3_Missense_Mutation_p.R633M|ABL2_uc001gmh.3_Missense_Mutation_p.R612M|ABL2_uc010pne.1_Missense_Mutation_p.R612M	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	648					axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GCCCCCCTTCCTATCCCTGGT	0.537			T	ETV6	AML								9	165	---	---	---	---	PASS
CACNA1E	777	broad.mit.edu	37	1	181740495	181740495	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:181740495T>C	uc001gow.2	+	36	5113	c.4948T>C	c.(4948-4950)TTT>CTT	p.F1650L	CACNA1E_uc009wxs.2_Missense_Mutation_p.F1538L|CACNA1E_uc001gox.1_Missense_Mutation_p.F876L|CACNA1E_uc009wxt.2_Missense_Mutation_p.F876L	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1650	Extracellular (Potential).|IV.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CCGGAGTTTCTTTGGGTCCCT	0.473													3	12	---	---	---	---	PASS
KIF21B	23046	broad.mit.edu	37	1	200946364	200946364	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:200946364G>A	uc001gvs.1	-	31	4618	c.4301C>T	c.(4300-4302)GCC>GTC	p.A1434V	KIF21B_uc001gvr.1_Missense_Mutation_p.A1421V|KIF21B_uc009wzl.1_Missense_Mutation_p.A1434V|KIF21B_uc010ppn.1_Missense_Mutation_p.A1421V	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1434	WD 3.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GATGCGGACGGCATTGCCCGA	0.632													29	79	---	---	---	---	PASS
PPP1R12B	4660	broad.mit.edu	37	1	202400696	202400696	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:202400696G>T	uc001gya.1	+	8	1234	c.1090G>T	c.(1090-1092)GAG>TAG	p.E364*	PPP1R12B_uc001gxy.2_Nonsense_Mutation_p.E364*|PPP1R12B_uc009xad.1_Nonsense_Mutation_p.E170*|PPP1R12B_uc009xae.1_Nonsense_Mutation_p.E364*|PPP1R12B_uc001gxz.1_Nonsense_Mutation_p.E364*	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	364	Glu-rich.				regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			CAGCTCAGAGGAGGAGGAAGG	0.418													69	88	---	---	---	---	PASS
SPATA17	128153	broad.mit.edu	37	1	218036154	218036154	+	Silent	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:218036154A>G	uc001hlh.1	+	10	1070	c.1044A>G	c.(1042-1044)TCA>TCG	p.S348S	SPATA17_uc001hli.2_Silent_p.S348S	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	348						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		AGCTCTTCTCAAAGTATGGAA	0.284													43	52	---	---	---	---	PASS
OBSCN	84033	broad.mit.edu	37	1	228456387	228456387	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:228456387G>T	uc009xez.1	+	17	5062	c.5018G>T	c.(5017-5019)CGC>CTC	p.R1673L	OBSCN_uc001hsn.2_Missense_Mutation_p.R1673L|OBSCN_uc001hso.2_Missense_Mutation_p.R119L	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1673	Ig-like 17.			RV -> HM (in Ref. 1; CAC85750).	apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TCGAAAGTGCGCGTGGAGGCC	0.687													41	44	---	---	---	---	PASS
NUP133	55746	broad.mit.edu	37	1	229596457	229596457	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:229596457T>A	uc001htn.2	-	20	2837	c.2745A>T	c.(2743-2745)TTA>TTT	p.L915F		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	915					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				TGGGCTGAGATAATAATTTGC	0.348													22	51	---	---	---	---	PASS
TAF5L	27097	broad.mit.edu	37	1	229730434	229730434	+	Silent	SNP	C	T	T	rs148664199		TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:229730434C>T	uc001htq.2	-	5	1546	c.1380G>A	c.(1378-1380)TCG>TCA	p.S460S		NM_014409	NP_055224	O75529	TAF5L_HUMAN	PCAF associated factor 65 beta isoform a	460	WD 4.				histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				AAAGCCTCACCGAGTTCCCCT	0.582													21	113	---	---	---	---	PASS
LYST	1130	broad.mit.edu	37	1	235840490	235840490	+	Splice_Site	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:235840490T>A	uc001hxj.2	-	50	11116	c.10941_splice	c.e50-1	p.R3647_splice	LYST_uc001hxi.2_Splice_Site_p.R871_splice	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator						defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TAGCATAACCTGAAAGAAAAA	0.363									Chediak-Higashi_syndrome				21	23	---	---	---	---	PASS
GPR137B	7107	broad.mit.edu	37	1	236343287	236343287	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:236343287G>A	uc001hxq.2	+	4	887	c.796G>A	c.(796-798)GTC>ATC	p.V266I	GPR137B_uc001hxr.1_Missense_Mutation_p.V48I|GPR137B_uc009xge.2_RNA	NM_003272	NP_003263	O60478	G137B_HUMAN	G protein-coupled receptor 137B	266	Extracellular (Potential).					integral to plasma membrane|membrane fraction					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			GAACAAGAGCGTCCATTCCTT	0.468													20	71	---	---	---	---	PASS
HNRNPU	3192	broad.mit.edu	37	1	245020153	245020153	+	Silent	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:245020153T>A	uc001iaz.1	-	9	1838	c.1620A>T	c.(1618-1620)GCA>GCT	p.A540A	HNRNPU_uc001iaw.1_RNA|HNRNPU_uc001iax.1_RNA|HNRNPU_uc001iay.1_Silent_p.A264A|HNRNPU_uc001iba.1_Silent_p.A521A|HNRNPU_uc001ibb.1_Silent_p.A228A	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U	540					CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			TCTTAAAACCTGCCACCTATA	0.363													34	70	---	---	---	---	PASS
AHCTF1	25909	broad.mit.edu	37	1	247050612	247050612	+	Silent	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:247050612T>C	uc001ibu.1	-	19	2380	c.2373A>G	c.(2371-2373)ACA>ACG	p.T791T	AHCTF1_uc001ibv.1_Silent_p.T800T|AHCTF1_uc009xgs.1_5'UTR	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	791	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TGGGAGTGTCTGTTTTGTTGG	0.353													44	40	---	---	---	---	PASS
OR2W5	441932	broad.mit.edu	37	1	247654714	247654714	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:247654714C>T	uc001icz.1	+	1	285	c.285C>T	c.(283-285)CAC>CAT	p.H95H		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	95					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TCACCTACCACGGCTGTGTGG	0.557													42	36	---	---	---	---	PASS
OR2G2	81470	broad.mit.edu	37	1	247752503	247752503	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:247752503A>T	uc010pyy.1	+	1	842	c.842A>T	c.(841-843)TAC>TTC	p.Y281F		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	281	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TCTCTCTTCTACACTGTGGTA	0.358													72	100	---	---	---	---	PASS
OR2L8	391190	broad.mit.edu	37	1	248112725	248112725	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:248112725T>A	uc001idt.1	+	1	566	c.566T>A	c.(565-567)ATG>AAG	p.M189K	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CTGGCCTGCATGGACACCTGG	0.468													16	33	---	---	---	---	PASS
OR2L8	391190	broad.mit.edu	37	1	248112726	248112726	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:248112726G>T	uc001idt.1	+	1	567	c.567G>T	c.(565-567)ATG>ATT	p.M189I	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TGGCCTGCATGGACACCTGGG	0.473													16	32	---	---	---	---	PASS
DNMT3A	1788	broad.mit.edu	37	2	25467478	25467478	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:25467478T>C	uc002rgc.2	-	14	1855	c.1598A>G	c.(1597-1599)TAC>TGC	p.Y533C	DNMT3A_uc002rgd.2_Missense_Mutation_p.Y533C|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.Y344C	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	533	Interaction with the PRC2/EED-EZH2 complex (By similarity).|ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTAGGACTGGTAGCCGTCGTC	0.602			Mis|F|N|S		AML								15	3	---	---	---	---	PASS
LTBP1	4052	broad.mit.edu	37	2	33525541	33525541	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:33525541A>G	uc002ros.2	+	21	3262	c.3262A>G	c.(3262-3264)AAT>GAT	p.N1088D	LTBP1_uc002rot.2_Missense_Mutation_p.N762D|LTBP1_uc002rou.2_Missense_Mutation_p.N761D|LTBP1_uc002rov.2_Missense_Mutation_p.N708D|LTBP1_uc010ymz.1_Missense_Mutation_p.N761D|LTBP1_uc010yna.1_Missense_Mutation_p.N708D|LTBP1_uc010ynb.1_Missense_Mutation_p.N27D	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1087	EGF-like 9; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TCAGCAAGGGAATCTATGTGT	0.488													39	23	---	---	---	---	PASS
DYNC2LI1	51626	broad.mit.edu	37	2	44016793	44016793	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:44016793T>C	uc002rtk.2	+	5	349	c.253T>C	c.(253-255)TGG>CGG	p.W85R	DYNC2LI1_uc002rth.2_Missense_Mutation_p.W85R|DYNC2LI1_uc002rti.2_Missense_Mutation_p.W85R|DYNC2LI1_uc002rtj.2_Missense_Mutation_p.W85R|DYNC2LI1_uc002rtl.2_Missense_Mutation_p.W85R|DYNC2LI1_uc010ynz.1_5'UTR	NM_016008	NP_057092	Q8TCX1	DC2L1_HUMAN	dynein 2 light intermediate chain isoform 1	85						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CGCTCACTTTTGGGAACTCGG	0.378													34	13	---	---	---	---	PASS
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48808748	48808748	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:48808748C>T	uc010yol.1	+	1	1023	c.976C>T	c.(976-978)CCA>TCA	p.P326S	STON1_uc002rwo.3_Missense_Mutation_p.P326S|STON1_uc010fbm.2_Missense_Mutation_p.P326S|STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.P326S|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Missense_Mutation_p.P326S	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	326					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ACAGCTTGATCCATATTGTAG	0.378													7	265	---	---	---	---	PASS
FSHR	2492	broad.mit.edu	37	2	49210251	49210251	+	Silent	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:49210251G>T	uc002rww.2	-	7	653	c.579C>A	c.(577-579)ACC>ACA	p.T193T	FSHR_uc002rwx.2_Silent_p.T193T|FSHR_uc010fbn.2_Silent_p.T167T|FSHR_uc010fbo.1_RNA	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	193	LRR 7.|Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	CATCTAGTTGGGTTCCATTGA	0.368									Gonadal_Dysgenesis_46_XX				11	72	---	---	---	---	PASS
CCDC88A	55704	broad.mit.edu	37	2	55576722	55576722	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:55576722C>T	uc002ryv.2	-	9	1656	c.814G>A	c.(814-816)GAG>AAG	p.E272K	CCDC88A_uc010yoz.1_Missense_Mutation_p.E272K|CCDC88A_uc010ypa.1_Missense_Mutation_p.E272K|CCDC88A_uc010ypb.1_Missense_Mutation_p.E174K	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	272	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						AACAACTGCTCAGTCTTTTCC	0.328													11	23	---	---	---	---	PASS
CCDC85A	114800	broad.mit.edu	37	2	56603032	56603032	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:56603032C>G	uc002rzn.2	+	5	2036	c.1534C>G	c.(1534-1536)CCT>GCT	p.P512A		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	512										breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ACATGCCACACCTTCCCAGCA	0.473													21	50	---	---	---	---	PASS
KIAA1841	84542	broad.mit.edu	37	2	61319611	61319611	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:61319611G>T	uc002saw.3	+	11	1404	c.1101G>T	c.(1099-1101)TGG>TGT	p.W367C	KIAA1841_uc002sax.3_Missense_Mutation_p.W221C|KIAA1841_uc002say.2_Missense_Mutation_p.W367C	NM_001129993	NP_001123465	Q6NSI8	K1841_HUMAN	KIAA1841 protein isoform a	367											0			Epithelial(17;0.193)			ATAAGACATGGGATGTTCATG	0.284													8	384	---	---	---	---	PASS
USP34	9736	broad.mit.edu	37	2	61459593	61459593	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:61459593C>T	uc002sbe.2	-	58	7129	c.7107G>A	c.(7105-7107)GTG>GTA	p.V2369V	USP34_uc002sbf.2_Silent_p.V519V	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	2369					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			TTACCTGTCTCACAATTTGAT	0.308													81	149	---	---	---	---	PASS
USP34	9736	broad.mit.edu	37	2	61459646	61459646	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:61459646C>G	uc002sbe.2	-	58	7076	c.7054G>C	c.(7054-7056)GAT>CAT	p.D2352H	USP34_uc002sbf.2_Missense_Mutation_p.D502H	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	2352					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			CAGTCGTCATCAGCCATACGA	0.308													69	152	---	---	---	---	PASS
APLF	200558	broad.mit.edu	37	2	68772369	68772369	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:68772369A>T	uc002sep.2	+	8	1384	c.1211A>T	c.(1210-1212)TAT>TTT	p.Y404F	APLF_uc002seq.1_RNA|APLF_uc010fdf.2_Missense_Mutation_p.Y380F|APLF_uc002ser.1_Missense_Mutation_p.Y135F	NM_173545	NP_775816	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	404					double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			ovary(2)	2						GATAGTGATTATGGAGGTGTA	0.413													21	38	---	---	---	---	PASS
ARHGAP25	9938	broad.mit.edu	37	2	69046265	69046265	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:69046265G>T	uc002seu.2	+	9	1375	c.1011G>T	c.(1009-1011)CAG>CAT	p.Q337H	ARHGAP25_uc010fdg.2_Missense_Mutation_p.Q338H|ARHGAP25_uc010yql.1_Missense_Mutation_p.Q298H|ARHGAP25_uc002sev.2_Missense_Mutation_p.Q331H|ARHGAP25_uc002sew.2_Missense_Mutation_p.Q330H|ARHGAP25_uc002sex.2_Missense_Mutation_p.Q331H|ARHGAP25_uc002sey.2_Missense_Mutation_p.Q64H	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	337	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						GGACTCCTCAGATCCAAAGAG	0.498													8	341	---	---	---	---	PASS
DCTN1	1639	broad.mit.edu	37	2	74593698	74593698	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:74593698G>A	uc002skx.2	-	22	2827	c.2516C>T	c.(2515-2517)GCT>GTT	p.A839V	DCTN1_uc002skt.1_5'Flank|DCTN1_uc002skv.2_Missense_Mutation_p.A705V|DCTN1_uc002sku.2_Missense_Mutation_p.A705V|DCTN1_uc002skw.1_Missense_Mutation_p.A815V|DCTN1_uc010ffd.2_Missense_Mutation_p.A819V|DCTN1_uc002sky.2_Missense_Mutation_p.A802V	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	839					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						CTGCAGCACAGCCACGACCCA	0.582													53	136	---	---	---	---	PASS
TMEM150A	129303	broad.mit.edu	37	2	85826823	85826823	+	Silent	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:85826823C>A	uc002spw.1	-	6	1120	c.399G>T	c.(397-399)GTG>GTT	p.V133V	TMEM150A_uc002spx.1_Silent_p.V49V|TMEM150A_uc002spz.1_Silent_p.V80V|TMEM150A_uc002sqa.1_Silent_p.V49V|TMEM150A_uc002spy.1_Silent_p.V133V	NM_001031738	NP_001026908	Q86TG1	T150A_HUMAN	transmembrane protein 150A isoform 1	133	Extracellular (Potential).					integral to membrane|plasma membrane					0						TGGCATGATCCACCTGGGCCC	0.607													5	59	---	---	---	---	PASS
EIF2AK3	9451	broad.mit.edu	37	2	88857340	88857340	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:88857340T>C	uc002stc.3	-	17	3467	c.3265A>G	c.(3265-3267)AGA>GGA	p.R1089G		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	1089	Cytoplasmic (Potential).				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						GACCTCTGTCTGAGCACTGTT	0.453													42	29	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	89384807	89384807	+	RNA	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:89384807C>T	uc010ytr.1	-	50		c.5333G>A			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		CTGGTGGATGCACCATAGATG	0.577													23	13	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	89417018	89417018	+	RNA	SNP	C	T	T	rs77497402		TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:89417018C>T	uc010ytr.1	-	42		c.4584G>A			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		TGATACCAGCCTAAATCATTT	0.527													48	18	---	---	---	---	PASS
KIAA1310	55683	broad.mit.edu	37	2	97276805	97276805	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:97276805C>T	uc002swn.3	-	10	1303	c.1157G>A	c.(1156-1158)AGA>AAA	p.R386K	KIAA1310_uc002swh.3_Missense_Mutation_p.R274K|KIAA1310_uc002swi.3_Missense_Mutation_p.R287K|KIAA1310_uc002swj.3_RNA|KIAA1310_uc002swk.3_Missense_Mutation_p.R299K|KIAA1310_uc010fhz.2_Missense_Mutation_p.R180K|KIAA1310_uc002swl.3_Missense_Mutation_p.R287K|KIAA1310_uc002swm.3_RNA|KIAA1310_uc010yur.1_Missense_Mutation_p.R180K|KIAA1310_uc002swp.1_Missense_Mutation_p.R287K|KIAA1310_uc002swq.1_Missense_Mutation_p.R158K|KIAA1310_uc010fhy.1_Missense_Mutation_p.R287K	NM_001115016	NP_001108488	Q9P2N6	K1310_HUMAN	hypothetical protein LOC55683 isoform a	386											0						TCTTACCCCTCTGGGGCCATC	0.512													49	70	---	---	---	---	PASS
MAP4K4	9448	broad.mit.edu	37	2	102452415	102452415	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:102452415C>T	uc002tbg.2	+	9	803	c.748C>T	c.(748-750)CCT>TCT	p.P250S	MAP4K4_uc002tbc.2_Missense_Mutation_p.P250S|MAP4K4_uc002tbd.2_Missense_Mutation_p.P250S|MAP4K4_uc002tbe.2_Missense_Mutation_p.P250S|MAP4K4_uc002tbf.2_Missense_Mutation_p.P250S|MAP4K4_uc010yvy.1_Missense_Mutation_p.P250S|MAP4K4_uc002tbh.2_Missense_Mutation_p.P250S|MAP4K4_uc002tbi.2_Intron|MAP4K4_uc010yvz.1_Missense_Mutation_p.P230S|MAP4K4_uc010fiw.1_Missense_Mutation_p.P92S|MAP4K4_uc002tbj.1_Missense_Mutation_p.P146S	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	250	Protein kinase.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CAGAAACCCTCCTCCCCGGCT	0.408													6	22	---	---	---	---	PASS
SLC9A4	389015	broad.mit.edu	37	2	103142717	103142717	+	Splice_Site	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:103142717G>A	uc002tbz.3	+	11	2408	c.1951_splice	c.e11-1	p.A651_splice		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen						regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						GCTACCCACAGGCTGGCACCA	0.418													36	72	---	---	---	---	PASS
RANBP2	5903	broad.mit.edu	37	2	109384025	109384025	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:109384025A>G	uc002tem.3	+	20	7156	c.7030A>G	c.(7030-7032)AAA>GAA	p.K2344E		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2344	RanBD1 3.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						CAGATATGATAAAGATGTTGG	0.363													109	145	---	---	---	---	PASS
DPP10	57628	broad.mit.edu	37	2	116572495	116572495	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:116572495G>A	uc002tla.1	+	20	2284	c.1827G>A	c.(1825-1827)CTG>CTA	p.L609L	DPP10_uc002tlb.1_Silent_p.L559L|DPP10_uc002tlc.1_Silent_p.L605L|DPP10_uc002tle.2_Silent_p.L613L|DPP10_uc002tlf.1_Silent_p.L602L	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	609	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						TCCAGGGTCTGAAAATTTTGC	0.383													15	59	---	---	---	---	PASS
CNTNAP5	129684	broad.mit.edu	37	2	125671847	125671847	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:125671847A>C	uc002tno.2	+	24	4267	c.3903A>C	c.(3901-3903)AAA>AAC	p.K1301N	CNTNAP5_uc010flu.2_Missense_Mutation_p.K1302N	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	1301	Cytoplasmic (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GCGAGTGTAAACGGGAATATT	0.408													17	33	---	---	---	---	PASS
POLR2D	5433	broad.mit.edu	37	2	128610593	128610593	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:128610593C>A	uc002tpj.2	-	2	215	c.160G>T	c.(160-162)GAA>TAA	p.E54*	POLR2D_uc002tpk.2_Nonsense_Mutation_p.E54*	NM_004805	NP_004796	O15514	RPB4_HUMAN	DNA directed RNA polymerase II polypeptide D	54					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA-directed RNA polymerase activity|nucleotide binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0675)		AGCTCCTGTTCGTCCTCTGCA	0.418													9	68	---	---	---	---	PASS
SAP130	79595	broad.mit.edu	37	2	128707902	128707902	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:128707902G>A	uc002tpp.2	-	16	2608	c.2476C>T	c.(2476-2478)CTA>TTA	p.L826L	SAP130_uc002tpn.2_Silent_p.L586L|SAP130_uc002tpo.2_Silent_p.L606L|SAP130_uc010fmd.2_Silent_p.L861L	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	826	Pro-rich.				histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		CCAGGTGGTAGGTCACTTGTA	0.488													37	47	---	---	---	---	PASS
SAP130	79595	broad.mit.edu	37	2	128747236	128747236	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:128747236C>G	uc002tpp.2	-	13	1892	c.1760G>C	c.(1759-1761)GGC>GCC	p.G587A	SAP130_uc002tpn.2_Missense_Mutation_p.G348A|SAP130_uc002tpo.2_Missense_Mutation_p.G332A|SAP130_uc010fmd.2_Missense_Mutation_p.G587A|SAP130_uc002tpq.1_Missense_Mutation_p.G560A	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	587					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		TCCCTGTGTGCCAAGTGGTGC	0.567													22	42	---	---	---	---	PASS
UGGT1	56886	broad.mit.edu	37	2	128913974	128913974	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:128913974T>A	uc002tps.2	+	21	2423	c.2245T>A	c.(2245-2247)TCC>ACC	p.S749T	UGGT1_uc010fme.1_Missense_Mutation_p.S624T|UGGT1_uc002tpr.2_Missense_Mutation_p.S725T	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	749					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						AGGAATGTCCTCCAAGGAAAT	0.299													14	28	---	---	---	---	PASS
MGAT5	4249	broad.mit.edu	37	2	135180449	135180449	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:135180449G>C	uc002ttv.1	+	13	1898	c.1753G>C	c.(1753-1755)GAG>CAG	p.E585Q		NM_002410	NP_002401	Q09328	MGT5A_HUMAN	N-acetylglucosaminyltransferase V	585	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0964)		CAACAATCAGGAGGAAGTAGA	0.433													6	62	---	---	---	---	PASS
LRP1B	53353	broad.mit.edu	37	2	141072507	141072507	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:141072507G>T	uc002tvj.1	-	83	13774	c.12802C>A	c.(12802-12804)CTA>ATA	p.L4268I		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4268	Extracellular (Potential).|EGF-like 11.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATTTACCTAGAACTGATGGT	0.353										TSP Lung(27;0.18)			15	22	---	---	---	---	PASS
LRP1B	53353	broad.mit.edu	37	2	141081480	141081480	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:141081480G>A	uc002tvj.1	-	81	13468	c.12496C>T	c.(12496-12498)CGT>TGT	p.R4166C		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4166	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTTTATAACGATGAGATATC	0.244										TSP Lung(27;0.18)			6	13	---	---	---	---	PASS
LRP1B	53353	broad.mit.edu	37	2	141533709	141533709	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:141533709C>T	uc002tvj.1	-	33	6430	c.5458G>A	c.(5458-5460)GGG>AGG	p.G1820R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1820	Extracellular (Potential).|LDL-receptor class B 18.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGAACTACCCCAGAAGTCTTA	0.418										TSP Lung(27;0.18)			7	32	---	---	---	---	PASS
NEB	4703	broad.mit.edu	37	2	152427088	152427088	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:152427088T>C	uc010fnx.2	-	80	12129	c.11938A>G	c.(11938-11940)ATG>GTG	p.M3980V	NEB_uc002txr.2_Missense_Mutation_p.M403V	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3980					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCCGCCTTCATTTCATCCCAG	0.483													5	9	---	---	---	---	PASS
SCN2A	6326	broad.mit.edu	37	2	166210793	166210793	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:166210793A>G	uc002udc.2	+	17	3301	c.3011A>G	c.(3010-3012)CAG>CGG	p.Q1004R	SCN2A_uc002udd.2_Missense_Mutation_p.Q1004R|SCN2A_uc002ude.2_Missense_Mutation_p.Q1004R	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1004	II.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AATAATCTCCAGATTGCTGTG	0.383													27	75	---	---	---	---	PASS
SCN1A	6323	broad.mit.edu	37	2	166870332	166870332	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:166870332C>A	uc010zcz.1	-	18	3612	c.3594G>T	c.(3592-3594)AGG>AGT	p.R1198S	SCN1A_uc002udo.3_Missense_Mutation_p.R1078S|SCN1A_uc010fpk.2_Missense_Mutation_p.R1050S	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1209	III.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GGAAACACGTCCTTCTCAGGT	0.398													13	19	---	---	---	---	PASS
SCN1A	6323	broad.mit.edu	37	2	166870333	166870333	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:166870333C>T	uc010zcz.1	-	18	3611	c.3593G>A	c.(3592-3594)AGG>AAG	p.R1198K	SCN1A_uc002udo.3_Missense_Mutation_p.R1078K|SCN1A_uc010fpk.2_Missense_Mutation_p.R1050K	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1209	III.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GAAACACGTCCTTCTCAGGTT	0.398													13	20	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179605328	179605328	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:179605328C>A	uc010zfh.1	-	46	12343	c.12119G>T	c.(12118-12120)GGG>GTG	p.G4040V	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.G3973V|TTN_uc010zfj.1_Missense_Mutation_p.G3848V|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGATAATTCCCTTCAGGTTC	0.388													15	71	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179665403	179665403	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:179665403G>A	uc002und.2	-	4	527	c.302C>T	c.(301-303)ACA>ATA	p.T101I	TTN_uc010zfg.1_Missense_Mutation_p.T101I|TTN_uc010zfh.1_Missense_Mutation_p.T101I|TTN_uc010zfi.1_Missense_Mutation_p.T101I|TTN_uc010zfj.1_Missense_Mutation_p.T101I|TTN_uc002unb.2_Missense_Mutation_p.T101I			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	101							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGTGGTGCTGTCTCAGCTGC	0.498													20	40	---	---	---	---	PASS
COL3A1	1281	broad.mit.edu	37	2	189876412	189876412	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:189876412G>T	uc002uqj.1	+	51	4430	c.4313G>T	c.(4312-4314)AGA>ATA	p.R1438I		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1438	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AAGGCTGTGAGACTACCTATT	0.393													9	30	---	---	---	---	PASS
GLS	2744	broad.mit.edu	37	2	191795262	191795262	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:191795262G>T	uc002usf.2	+	13	1789	c.1525G>T	c.(1525-1527)GGC>TGC	p.G509C	GLS_uc002use.2_Missense_Mutation_p.G509C|GLS_uc002usg.1_Missense_Mutation_p.G170C|GLS_uc002ush.2_Missense_Mutation_p.G170C|GLS_uc010zgi.1_Missense_Mutation_p.G80C|GLS_uc010zgj.1_Missense_Mutation_p.G14C	NM_014905	NP_055720	O94925	GLSK_HUMAN	glutaminase precursor	509					cellular amino acid biosynthetic process|glutamate secretion|glutamine catabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity			ovary(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00625)|Epithelial(96;0.0744)|all cancers(119;0.181)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GGATAAGATGGGCAACAGTGT	0.398													16	52	---	---	---	---	PASS
TRAK2	66008	broad.mit.edu	37	2	202250994	202250994	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:202250994G>T	uc002uyb.3	-	14	2356	c.1910C>A	c.(1909-1911)CCA>CAA	p.P637Q		NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	637				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding				0						CCCTGTTACTGGCTTGGATGT	0.418													4	26	---	---	---	---	PASS
ABCA12	26154	broad.mit.edu	37	2	215843761	215843761	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:215843761G>A	uc002vew.2	-	32	4964	c.4744C>T	c.(4744-4746)CCA>TCA	p.P1582S	ABCA12_uc002vev.2_Missense_Mutation_p.P1264S|ABCA12_uc010zjn.1_Missense_Mutation_p.P509S	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1582					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTTAAATTTGGACTCTAAGAG	0.458													12	38	---	---	---	---	PASS
RHBDD1	84236	broad.mit.edu	37	2	227773574	227773574	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:227773574A>C	uc002voi.2	+	5	813	c.692A>C	c.(691-693)CAA>CCA	p.Q231P	RHBDD1_uc010fxc.2_Missense_Mutation_p.Q231P|RHBDD1_uc002voj.2_Missense_Mutation_p.Q62P	NM_032276	NP_115652	Q8TEB9	RHBD1_HUMAN	rhomboid domain containing 1	231						integral to membrane	serine-type endopeptidase activity			ovary(1)	1		Renal(207;0.023)|all_lung(227;0.13)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;1.47e-11)|all cancers(144;1.52e-08)|Lung(261;0.0128)|LUSC - Lung squamous cell carcinoma(224;0.0175)		CCAGGACGGCAATACTACTTT	0.318													12	28	---	---	---	---	PASS
SPHKAP	80309	broad.mit.edu	37	2	228884383	228884383	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:228884383G>T	uc002vpq.2	-	7	1234	c.1187C>A	c.(1186-1188)GCA>GAA	p.A396E	SPHKAP_uc002vpp.2_Missense_Mutation_p.A396E|SPHKAP_uc010zlx.1_Missense_Mutation_p.A396E	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	396						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CACGGATTCTGCTAAATTTGT	0.448													19	37	---	---	---	---	PASS
SPHKAP	80309	broad.mit.edu	37	2	228996713	228996713	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:228996713T>C	uc002vpq.2	-	2	168	c.121A>G	c.(121-123)ATC>GTC	p.I41V	SPHKAP_uc002vpp.2_Missense_Mutation_p.I41V|SPHKAP_uc010zlx.1_Missense_Mutation_p.I41V	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	41						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CAGGCTGTGATGGAGTTCCCC	0.473													12	28	---	---	---	---	PASS
ALPP	250	broad.mit.edu	37	2	233245354	233245354	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:233245354T>G	uc002vsq.2	+	8	1052	c.887T>G	c.(886-888)ATG>AGG	p.M296R	ALPP_uc002vsr.2_5'Flank	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	296						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		CCTGGAGACATGAAATACGAG	0.627													4	36	---	---	---	---	PASS
UGT1A3	54659	broad.mit.edu	37	2	234638577	234638577	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:234638577A>G	uc002vuy.2	+	1	805	c.805A>G	c.(805-807)ATC>GTC	p.I269V	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Missense_Mutation_p.I269V	NM_019093	NP_061966	P35503	UD13_HUMAN	UDP glycosyltransferase 1 family, polypeptide A3	269					flavonoid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CCCCAGGCCAATCATGCCCAA	0.507													31	78	---	---	---	---	PASS
COL6A3	1293	broad.mit.edu	37	2	238277716	238277716	+	Nonsense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:238277716G>A	uc002vwl.2	-	10	4675	c.4390C>T	c.(4390-4392)CGA>TGA	p.R1464*	COL6A3_uc002vwo.2_Nonsense_Mutation_p.R1258*|COL6A3_uc010znj.1_Nonsense_Mutation_p.R857*	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1464	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TTGAGTCTTCGAACAATCCTG	0.473													5	33	---	---	---	---	PASS
FARP2	9855	broad.mit.edu	37	2	242407665	242407665	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr2:242407665G>A	uc002wbi.1	+	18	2121	c.2004G>A	c.(2002-2004)AAG>AAA	p.K668K		NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	668	DH.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		AGCTGCAGAAGGTCTGCTACT	0.552													28	48	---	---	---	---	PASS
MYH15	22989	broad.mit.edu	37	3	108147433	108147433	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:108147433T>A	uc003dxa.1	-	28	3725	c.3668A>T	c.(3667-3669)CAG>CTG	p.Q1223L		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1223	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						CTTGACCTGCTGTAGATTTTC	0.483													30	85	---	---	---	---	PASS
DPPA2	151871	broad.mit.edu	37	3	109023411	109023411	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:109023411C>A	uc003dxo.2	-	7	1012	c.765G>T	c.(763-765)AGG>AGT	p.R255S		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	255						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						AAATCATCCTCCTGTGAGTGG	0.517													5	67	---	---	---	---	PASS
ABHD10	55347	broad.mit.edu	37	3	111698038	111698038	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:111698038C>G	uc003dyk.3	+	1	211	c.130C>G	c.(130-132)CGG>GGG	p.R44G	ABHD10_uc011bhq.1_5'UTR	NM_018394	NP_060864	Q9NUJ1	ABHDA_HUMAN	abhydrolase domain containing 10 precursor	44						mitochondrion	serine-type peptidase activity				0						GCGGGCGCCACGGTGGCTCCC	0.662													14	24	---	---	---	---	PASS
DTX3L	151636	broad.mit.edu	37	3	122288682	122288682	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:122288682C>T	uc003efk.2	+	3	1835	c.1746C>T	c.(1744-1746)TGC>TGT	p.C582C	DTX3L_uc010hrj.2_Intron	NM_138287	NP_612144	Q8TDB6	DTX3L_HUMAN	deltex 3-like	582	RING-type.				histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)	4				GBM - Glioblastoma multiforme(114;0.0459)		ATGAATTCTGCGCCCCTTGTA	0.453													7	155	---	---	---	---	PASS
SEMA5B	54437	broad.mit.edu	37	3	122645282	122645282	+	Silent	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:122645282A>G	uc003efz.1	-	9	1397	c.1093T>C	c.(1093-1095)TTG>CTG	p.L365L	SEMA5B_uc011bju.1_Silent_p.L307L|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Silent_p.L365L|SEMA5B_uc010hro.1_Silent_p.L307L|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	365	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		TGCTCCGGCAAGTGGAAGGCA	0.602													11	18	---	---	---	---	PASS
ALG1L	200810	broad.mit.edu	37	3	125651529	125651529	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:125651529C>A	uc003eig.1	-	3	288	c.124G>T	c.(124-126)GGA>TGA	p.G42*		NM_001015050	NP_001015050	Q6GMV1	ALG1L_HUMAN	asparagine-linked glycosylation 1-like	42							transferase activity, transferring glycosyl groups				0						AGGTTGTGTCCATCAAGAGTA	0.373													5	84	---	---	---	---	PASS
SOX14	8403	broad.mit.edu	37	3	137483975	137483975	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:137483975G>C	uc003erm.1	+	1	397	c.349G>C	c.(349-351)GGC>CGC	p.G117R		NM_004189	NP_004180	O95416	SOX14_HUMAN	SRY-box 14	117					negative regulation of transcription from RNA polymerase II promoter|nervous system development|transcription, DNA-dependent	nucleus	sequence-specific DNA binding				0						GGCCTCCGACGGCCTCCTGAG	0.692													15	6	---	---	---	---	PASS
CLSTN2	64084	broad.mit.edu	37	3	140281797	140281797	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:140281797A>C	uc003etn.2	+	14	2547	c.2357A>C	c.(2356-2358)GAG>GCG	p.E786A		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	786	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						TTCAACTTGGAGGTGAGTGGG	0.552										HNSCC(16;0.037)			11	28	---	---	---	---	PASS
SLITRK3	22865	broad.mit.edu	37	3	164906580	164906580	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:164906580C>A	uc003fej.3	-	2	2483	c.2039G>T	c.(2038-2040)CGA>CTA	p.R680L	SLITRK3_uc003fek.2_Missense_Mutation_p.R680L	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	680	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						TCGACGCCTTCGGAGCACGTA	0.522										HNSCC(40;0.11)			48	36	---	---	---	---	PASS
GOLIM4	27333	broad.mit.edu	37	3	167758633	167758633	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:167758633C>A	uc003ffe.2	-	7	969	c.625G>T	c.(625-627)GAG>TAG	p.E209*	GOLIM4_uc011bpe.1_Nonsense_Mutation_p.E209*|GOLIM4_uc011bpf.1_Intron|GOLIM4_uc011bpg.1_Intron	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	209	Potential.|Golgi targeting.|Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						TGTTCATGCTCGGAGAGTAAA	0.413													4	106	---	---	---	---	PASS
SAMD7	344658	broad.mit.edu	37	3	169644749	169644749	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:169644749C>G	uc003fgd.2	+	6	966	c.699C>G	c.(697-699)AGC>AGG	p.S233R	SAMD7_uc003fge.2_Missense_Mutation_p.S233R|SAMD7_uc011bpo.1_Missense_Mutation_p.S134R	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	233										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			AAGCACCCAGCAACCAGAAGT	0.483													75	86	---	---	---	---	PASS
PRKCI	5584	broad.mit.edu	37	3	170002300	170002300	+	Silent	SNP	G	A	A	rs146346249		TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:170002300G>A	uc003fgs.2	+	12	1357	c.1119G>A	c.(1117-1119)GGG>GGA	p.G373G		NM_002740	NP_002731	P41743	KPCI_HUMAN	protein kinase C, iota	373	Protein kinase.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			ATGAGCGAGGGATAATTTATA	0.318													20	41	---	---	---	---	PASS
PIK3CA	5290	broad.mit.edu	37	3	178917478	178917478	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:178917478G>A	uc003fjk.2	+	3	510	c.353G>A	c.(352-354)GGT>GAT	p.G118D		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	118					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G118D(6)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TTTATTAAAGGTTTTGCTATC	0.338		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			9	21	---	---	---	---	PASS
ACTL6A	86	broad.mit.edu	37	3	179287884	179287884	+	Silent	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:179287884G>T	uc003fjw.2	+	3	305	c.132G>T	c.(130-132)GTG>GTT	p.V44V	ACTL6A_uc003fjx.2_Silent_p.V2V|ACTL6A_uc003fjy.2_Silent_p.V2V	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	44					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			TTGGTATGGTGGTAGAAAGAG	0.408													5	94	---	---	---	---	PASS
MUC4	4585	broad.mit.edu	37	3	195515841	195515841	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:195515841G>A	uc011bto.1	-	2	3070	c.2610C>T	c.(2608-2610)GGC>GGT	p.G870G	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Silent_p.G752G	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	875	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GATGAAAGGTGCCGGGGACGA	0.592													9	18	---	---	---	---	PASS
RNF168	165918	broad.mit.edu	37	3	196199439	196199439	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:196199439T>C	uc003fwq.2	-	6	1505	c.967A>G	c.(967-969)AAA>GAA	p.K323E	RNF168_uc010iah.2_Missense_Mutation_p.K156E|uc010iag.1_5'Flank	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	323					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		CATAACTCTTTCCCATGATTG	0.468													9	59	---	---	---	---	PASS
NCAPG	64151	broad.mit.edu	37	4	17826672	17826672	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr4:17826672G>A	uc003gpp.2	+	10	1641	c.1465G>A	c.(1465-1467)GAA>AAA	p.E489K	NCAPG_uc011bxj.1_5'UTR	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	489					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		AAGAAAGAAAGAACTCAAGGT	0.388													4	9	---	---	---	---	PASS
DHX15	1665	broad.mit.edu	37	4	24578074	24578074	+	Nonsense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr4:24578074G>C	uc003gqx.2	-	2	467	c.299C>G	c.(298-300)TCA>TGA	p.S100*		NM_001358	NP_001349	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 15	100					mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(1)	1		Breast(46;0.0503)				GGCATGCGTTGAATGAGCAGA	0.453													35	73	---	---	---	---	PASS
SLC34A2	10568	broad.mit.edu	37	4	25677904	25677904	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr4:25677904T>A	uc003grr.2	+	13	1687	c.1606T>A	c.(1606-1608)TTC>ATC	p.F536I	SLC34A2_uc003grs.2_Missense_Mutation_p.F535I|SLC34A2_uc010iev.2_Missense_Mutation_p.F535I	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	536	Helical; Name=M7; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				CCTGATCATCTTCTTCTTCCT	0.607													52	85	---	---	---	---	PASS
UGDH	7358	broad.mit.edu	37	4	39511414	39511414	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr4:39511414C>A	uc003guk.1	-	6	1093	c.777G>T	c.(775-777)CAG>CAT	p.Q259H	UGDH_uc011byp.1_Missense_Mutation_p.Q162H|UGDH_uc003gul.1_Missense_Mutation_p.Q192H	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	259					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	TTCCAATTCTCTGGTCCATTC	0.323													19	25	---	---	---	---	PASS
YIPF7	285525	broad.mit.edu	37	4	44631420	44631420	+	Silent	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr4:44631420C>G	uc010ifx.1	-	4	515	c.498G>C	c.(496-498)CTG>CTC	p.L166L	YIPF7_uc010ify.1_3'UTR	NM_182592	NP_872398	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	166	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0						GACACATTACCAGAAGCAAGG	0.438													5	9	---	---	---	---	PASS
COX7B2	170712	broad.mit.edu	37	4	46736995	46736995	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr4:46736995C>A	uc003gxf.2	-	3	395	c.215G>T	c.(214-216)AGA>ATA	p.R72I	COX7B2_uc010ige.2_RNA	NM_130902	NP_570972	Q8TF08	CX7B2_HUMAN	cytochrome c oxidase subunit VIIb2 precursor	72	Mitochondrial intermembrane (By similarity).					integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity				0						TGGGGTAACTCTGCCAACAGG	0.428													16	27	---	---	---	---	PASS
ATP10D	57205	broad.mit.edu	37	4	47548682	47548682	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr4:47548682G>C	uc003gxk.1	+	10	1602	c.1438G>C	c.(1438-1440)GAA>CAA	p.E480Q	ATP10D_uc003gxl.1_5'UTR|ATP10D_uc003gxj.3_Missense_Mutation_p.E465Q	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	480	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CTCTGAAGATGAAGATTTTAT	0.468													5	83	---	---	---	---	PASS
EREG	2069	broad.mit.edu	37	4	75246733	75246733	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr4:75246733C>G	uc003hie.1	+	3	323	c.157C>G	c.(157-159)CAG>GAG	p.Q53E	EREG_uc003hid.2_Missense_Mutation_p.Q47E	NM_001432	NP_001423	O14944	EREG_HUMAN	epiregulin preproprotein	53					angiogenesis|cell-cell signaling|cytokine-mediated signaling pathway|epidermal growth factor receptor signaling pathway|female meiosis|keratinocyte differentiation|keratinocyte proliferation|luteinizing hormone signaling pathway|mRNA transcription|negative regulation of epithelial cell proliferation|negative regulation of smooth muscle cell differentiation|negative regulation of transcription, DNA-dependent|oocyte maturation|organ morphogenesis|ovarian cumulus expansion|ovulation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of DNA replication|positive regulation of epidermal growth factor receptor activity|positive regulation of fibroblast proliferation|positive regulation of innate immune response|positive regulation of interleukin-6 biosynthetic process|positive regulation of mitosis|positive regulation of phosphorylation|positive regulation of smooth muscle cell proliferation|primary follicle stage|wound healing	extracellular space|integral to plasma membrane	epidermal growth factor receptor binding|growth factor activity			breast(1)|skin(1)	2			Lung(101;0.196)			TTTTACAGTTCAGACAGAAGA	0.398													17	55	---	---	---	---	PASS
NAAA	27163	broad.mit.edu	37	4	76852392	76852392	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr4:76852392C>T	uc003hjb.2	-	4	628	c.564G>A	c.(562-564)AAG>AAA	p.K188K	NAAA_uc003hja.2_Silent_p.K188K|NAAA_uc003hjc.3_Silent_p.K188K|NAAA_uc003hjd.3_RNA|NAAA_uc011cbq.1_Silent_p.K87K	NM_014435	NP_055250	Q02083	NAAA_HUMAN	N-acylethanolamine acid amidase isoform 1	188					lipid metabolic process	lysosome	hydrolase activity			skin(1)	1						AAACTGTAAACTTGTGTGGGC	0.393													10	22	---	---	---	---	PASS
QRFPR	84109	broad.mit.edu	37	4	122301679	122301679	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr4:122301679C>A	uc010inj.1	-	1	503	c.124G>T	c.(124-126)GGA>TGA	p.G42*	QRFPR_uc010ink.1_RNA|QRFPR_uc003ids.2_Nonsense_Mutation_p.G42*|QRFPR_uc010inl.1_Nonsense_Mutation_p.G42*	NM_198179	NP_937822	Q96P65	QRFPR_HUMAN	G protein-coupled receptor 103	42	Extracellular (Potential).					plasma membrane	neuropeptide Y receptor activity				0						TTGGCGCGTCCCGGCAGCTCT	0.657													7	3	---	---	---	---	PASS
TRPC3	7222	broad.mit.edu	37	4	122825537	122825537	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr4:122825537C>A	uc003ieg.2	-	8	2267	c.2193G>T	c.(2191-2193)ATG>ATT	p.M731I	TRPC3_uc010inr.2_Missense_Mutation_p.M603I|TRPC3_uc003ief.2_Missense_Mutation_p.M658I|TRPC3_uc011cgl.1_Missense_Mutation_p.M395I	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	646	Helical; (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						AAACGACCACCATAGTTACAT	0.328													8	15	---	---	---	---	PASS
TBC1D9	23158	broad.mit.edu	37	4	141592006	141592006	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr4:141592006C>T	uc010ioj.2	-	7	1406	c.1134G>A	c.(1132-1134)ATG>ATA	p.M378I		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	378						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				ATAGGAAGGTCATCCTGTTTC	0.448													10	88	---	---	---	---	PASS
TMEM144	55314	broad.mit.edu	37	4	159136383	159136383	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr4:159136383G>T	uc003ipx.2	+	4	670	c.150G>T	c.(148-150)TTG>TTT	p.L50F	TMEM144_uc010iqi.2_RNA	NM_018342	NP_060812	Q7Z5S9	TM144_HUMAN	transmembrane protein 144	50	Helical; (Potential).					integral to membrane					0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0539)		CCATATGGTTGGTTGCCTTGG	0.398													5	61	---	---	---	---	PASS
KLKB1	3818	broad.mit.edu	37	4	187159519	187159519	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr4:187159519G>T	uc003iyy.2	+	6	669	c.598G>T	c.(598-600)GGT>TGT	p.G200C	KLKB1_uc011clc.1_5'UTR|KLKB1_uc011cld.1_Missense_Mutation_p.G162C	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	200					blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		TTCAGAAATTGGTAATTGTAG	0.289													19	22	---	---	---	---	PASS
SLC9A3	6550	broad.mit.edu	37	5	485314	485314	+	Silent	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:485314C>G	uc003jbe.2	-	4	820	c.708G>C	c.(706-708)GCG>GCC	p.A236A	SLC9A3_uc011clx.1_Silent_p.A236A	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	236	Extracellular (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CACCTCCCAGCGCCACGAAAG	0.632													95	39	---	---	---	---	PASS
SEMA5A	9037	broad.mit.edu	37	5	9202306	9202306	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:9202306G>C	uc003jek.2	-	9	1405	c.693C>G	c.(691-693)TTC>TTG	p.F231L		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	231	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CTCGGAAAAAGAAGTAGGTAA	0.433													18	105	---	---	---	---	PASS
DNAH5	1767	broad.mit.edu	37	5	13714594	13714594	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:13714594C>A	uc003jfd.2	-	75	13087	c.13045G>T	c.(13045-13047)GAT>TAT	p.D4349Y	DNAH5_uc003jfc.2_Missense_Mutation_p.D517Y	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4349					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CGGGTCTCATCCCCTCCACCA	0.587									Kartagener_syndrome				11	123	---	---	---	---	PASS
CDH18	1016	broad.mit.edu	37	5	19591282	19591282	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:19591282C>G	uc003jgc.2	-	6	1260	c.883G>C	c.(883-885)GCT>CCT	p.A295P	CDH18_uc003jgd.2_Missense_Mutation_p.A295P|CDH18_uc011cnm.1_Missense_Mutation_p.A295P	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	295	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CCAGTGTCAGCATCATTTGCC	0.403													18	37	---	---	---	---	PASS
OSMR	9180	broad.mit.edu	37	5	38919038	38919038	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:38919038C>G	uc003jln.1	+	11	1826	c.1459C>G	c.(1459-1461)CCA>GCA	p.P487A	OSMR_uc011cpj.1_5'UTR	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	487	Fibronectin type-III 2.|Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					CCATTCCATTCCAGCACCAGC	0.438													19	135	---	---	---	---	PASS
PLCXD3	345557	broad.mit.edu	37	5	41382017	41382017	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:41382017C>T	uc003jmm.1	-	2	825	c.723G>A	c.(721-723)TCG>TCA	p.S241S		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	241					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						ATATAAAAAACGATCCCTTCT	0.502													19	112	---	---	---	---	PASS
FAM169A	26049	broad.mit.edu	37	5	74101044	74101044	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:74101044C>G	uc003kdm.2	-	7	779	c.736G>C	c.(736-738)GGA>CGA	p.G246R	FAM169A_uc010izm.2_Missense_Mutation_p.G186R|FAM169A_uc003kdl.2_Missense_Mutation_p.G64R	NM_015566	NP_056381	Q9Y6X4	F169A_HUMAN	hypothetical protein LOC26049	246											0						TACCAGTGTCCAACACCTTCA	0.383													16	8	---	---	---	---	PASS
FTMT	94033	broad.mit.edu	37	5	121187749	121187749	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:121187749C>T	uc003kss.2	+	1	100	c.91C>T	c.(91-93)CGT>TGT	p.R31C		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	31					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		GCTCCCGCTGCGTTGGGCCCC	0.766													8	1	---	---	---	---	PASS
HARS	3035	broad.mit.edu	37	5	140056476	140056476	+	Silent	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:140056476G>T	uc003lgv.2	-	10	1039	c.957C>A	c.(955-957)TCC>TCA	p.S319S	HARS_uc003lgu.2_Silent_p.S250S|HARS_uc011czm.1_Silent_p.S279S|HARS_uc003lgw.2_Silent_p.S299S|HARS_uc011czn.1_Silent_p.S259S|HARS_uc010jfu.2_Silent_p.S319S|HARS_uc011czo.1_Silent_p.S245S|HARS_uc011czp.1_Silent_p.S205S|HARS_uc011czq.1_Silent_p.S209S	NM_002109	NP_002100	P12081	SYHC_HUMAN	histidyl-tRNA synthetase	319					histidyl-tRNA aminoacylation	cytosol	ATP binding|histidine-tRNA ligase activity			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		L-Histidine(DB00117)	TCAGGTCAAAGGAGATCTGTG	0.552													5	82	---	---	---	---	PASS
PCDHB13	56123	broad.mit.edu	37	5	140594237	140594237	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:140594237T>A	uc003lja.1	+	1	729	c.542T>A	c.(541-543)GTC>GAC	p.V181D		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	181	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TATTTTCGGGTCCTCACCCGC	0.498													7	34	---	---	---	---	PASS
PCDHGB3	56102	broad.mit.edu	37	5	140750236	140750236	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:140750236G>A	uc003ljw.1	+	1	275	c.275G>A	c.(274-276)CGA>CAA	p.R92Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc011dat.1_Missense_Mutation_p.R92Q	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	92	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTATAGACCGAGAGGAGATT	0.443													15	164	---	---	---	---	PASS
GLRA1	2741	broad.mit.edu	37	5	151239385	151239385	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:151239385A>T	uc003lut.2	-	4	724	c.437T>A	c.(436-438)CTA>CAA	p.L146Q	GLRA1_uc003lur.2_Missense_Mutation_p.L146Q|GLRA1_uc003lus.2_Missense_Mutation_p.L63Q	NM_001146040	NP_001139512	P23415	GLRA1_HUMAN	glycine receptor, alpha 1 isoform 1 precursor	146	Extracellular (Probable).				muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGAGATCCTTAGCAATTTGTT	0.527													26	32	---	---	---	---	PASS
GEMIN5	25929	broad.mit.edu	37	5	154316660	154316660	+	Silent	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:154316660G>T	uc003lvx.3	-	2	335	c.252C>A	c.(250-252)ACC>ACA	p.T84T	GEMIN5_uc011ddk.1_Silent_p.T84T	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	84	WD 1.				ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CGTCGGAGCTGGTGGCACAGA	0.473													5	70	---	---	---	---	PASS
SGCD	6444	broad.mit.edu	37	5	156186285	156186285	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:156186285C>A	uc003lwd.3	+	8	1230	c.754C>A	c.(754-756)CCT>ACT	p.P252T	SGCD_uc003lwc.3_Missense_Mutation_p.P253T	NM_001128209	NP_001121681	Q92629	SGCD_HUMAN	delta-sarcoglycan isoform 3	252	Extracellular (Potential).				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma					0	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATCCTACACGCCTACAGGAAC	0.493													44	24	---	---	---	---	PASS
TIMD4	91937	broad.mit.edu	37	5	156381726	156381726	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:156381726G>A	uc003lwh.2	-	2	157	c.100C>T	c.(100-102)CAC>TAC	p.H34Y	TIMD4_uc010jii.2_Missense_Mutation_p.H34Y	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	34	Ig-like V-type.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTCACCCGGTGACCCAAAACC	0.512													11	4	---	---	---	---	PASS
ATP10B	23120	broad.mit.edu	37	5	160097495	160097495	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:160097495C>T	uc003lym.1	-	7	1497	c.650G>A	c.(649-651)TGT>TAT	p.C217Y	ATP10B_uc003lyp.2_Missense_Mutation_p.C217Y|ATP10B_uc011deg.1_Missense_Mutation_p.C261Y|ATP10B_uc003lyo.2_Missense_Mutation_p.C189Y	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	217	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTTCACGACACATCTTTGCTT	0.463													37	54	---	---	---	---	PASS
ODZ2	57451	broad.mit.edu	37	5	167671566	167671566	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:167671566C>A	uc010jjd.2	+	26	5635	c.5635C>A	c.(5635-5637)CTG>ATG	p.L1879M	ODZ2_uc003lzr.3_Missense_Mutation_p.L1649M|ODZ2_uc003lzt.3_Missense_Mutation_p.L1252M|ODZ2_uc010jje.2_Missense_Mutation_p.L1143M	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CAGCAGCGGGCTGGCAGCTGT	0.577													29	14	---	---	---	---	PASS
FOXI1	2299	broad.mit.edu	37	5	169535450	169535450	+	Silent	SNP	G	T	T	rs56128152	byFrequency	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr5:169535450G>T	uc003mai.3	+	2	1017	c.972G>T	c.(970-972)CCG>CCT	p.P324P	FOXI1_uc003maj.3_Silent_p.P229P	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	324					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCTTCTCCCCGCTCACCAACC	0.622									Pendred_syndrome				15	12	---	---	---	---	PASS
F13A1	2162	broad.mit.edu	37	6	6224962	6224962	+	Silent	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:6224962G>T	uc003mwv.2	-	7	1053	c.930C>A	c.(928-930)GTC>GTA	p.V310V	F13A1_uc011dib.1_Silent_p.V247V	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	310					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GGCCATACCGGACTGGATTCT	0.443													49	82	---	---	---	---	PASS
RREB1	6239	broad.mit.edu	37	6	7231198	7231198	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:7231198G>T	uc003mxc.2	+	10	3256	c.2866G>T	c.(2866-2868)GCC>TCC	p.A956S	RREB1_uc003mxb.2_Missense_Mutation_p.A956S|RREB1_uc010jnx.2_Missense_Mutation_p.A956S	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	956					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				TCCCAGCGAAGCCAAGAAGCC	0.612													8	9	---	---	---	---	PASS
HIST1H3B	8358	broad.mit.edu	37	6	26032069	26032069	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:26032069C>T	uc003nfs.1	-	1	220	c.220G>A	c.(220-222)GAA>AAA	p.E74K		NM_003537	NP_003528	P68431	H31_HUMAN	histone cluster 1, H3b	74					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						TGGGCGATTTCTCGCACCAGG	0.607													24	48	---	---	---	---	PASS
ZNF323	64288	broad.mit.edu	37	6	28297448	28297448	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:28297448C>T	uc003nla.2	-	2	413	c.13G>A	c.(13-15)GAG>AAG	p.E5K	ZNF323_uc003nld.2_Missense_Mutation_p.E5K|ZNF323_uc010jra.2_Missense_Mutation_p.E5K|ZNF323_uc003nlb.2_Intron|ZNF323_uc010jrb.2_Intron|ZNF323_uc003nlc.2_Missense_Mutation_p.E5K	NM_001135216	NP_001128688	Q96LW9	ZN323_HUMAN	zinc finger protein 323	5					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TACTGTTCCTCTGTTGAAGCC	0.423													23	40	---	---	---	---	PASS
OR14J1	442191	broad.mit.edu	37	6	29274902	29274902	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:29274902G>A	uc011dln.1	+	1	436	c.436G>A	c.(436-438)GTG>ATG	p.V146M		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AGTGATAGCTGTGTGGATTGC	0.483													34	45	---	---	---	---	PASS
STK19	8859	broad.mit.edu	37	6	31948290	31948290	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:31948290C>T	uc003nyv.2	+	6	1006	c.878C>T	c.(877-879)CCT>CTT	p.P293L	STK19_uc003nyt.2_Missense_Mutation_p.P246L|STK19_uc011dox.1_Missense_Mutation_p.P250L|STK19_uc003nyw.2_Missense_Mutation_p.P289L|STK19_uc010jtn.1_RNA|C4A_uc011doy.1_5'Flank|C4A_uc011doz.1_5'Flank|C4A_uc011dpa.1_5'Flank	NM_032454	NP_115830	P49842	STK19_HUMAN	serine/threonine kinase 19 isoform 2	293						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(4)	4						CTAGCTGTGCCTGGAGCTGGG	0.587													9	12	---	---	---	---	PASS
MEP1A	4224	broad.mit.edu	37	6	46787396	46787396	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:46787396G>A	uc010jzh.1	+	7	553	c.511G>A	c.(511-513)GAC>AAC	p.D171N	MEP1A_uc011dwg.1_5'UTR|MEP1A_uc011dwh.1_Missense_Mutation_p.D199N|MEP1A_uc011dwi.1_Missense_Mutation_p.D71N	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	171	Extracellular (Potential).|Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			GTCAAGGACGGACCGGGATGA	0.478													6	135	---	---	---	---	PASS
GPR116	221395	broad.mit.edu	37	6	46826157	46826157	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:46826157G>A	uc003oyo.3	-	17	3772	c.3483C>T	c.(3481-3483)GTC>GTT	p.V1161V	GPR116_uc011dwj.1_Silent_p.V716V|GPR116_uc011dwk.1_Silent_p.V590V|GPR116_uc003oyp.3_Silent_p.V1019V|GPR116_uc003oyq.3_Silent_p.V1161V|GPR116_uc010jzi.1_Silent_p.V833V	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	1161	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			TGAGCCAACAGACATTCTTCC	0.547													15	19	---	---	---	---	PASS
TFAP2D	83741	broad.mit.edu	37	6	50740417	50740417	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:50740417C>A	uc003paf.2	+	8	1711	c.1199C>A	c.(1198-1200)ACA>AAA	p.T400K	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	400	H-S-H (helix-span-helix), dimerization.						DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					ACTTTCCAAACAGTTCTCAGT	0.458													16	33	---	---	---	---	PASS
GCLC	2729	broad.mit.edu	37	6	53372322	53372322	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:53372322T>C	uc003pbw.1	-	9	1428	c.1040A>G	c.(1039-1041)GAC>GGC	p.D347G	GCLC_uc003pbv.1_Missense_Mutation_p.D71G	NM_001498	NP_001489	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	347					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			ovary(1)|central_nervous_system(1)	2	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	TATCGTCAAGTCGATGTCATT	0.383													14	45	---	---	---	---	PASS
RIMS1	22999	broad.mit.edu	37	6	72974741	72974741	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:72974741C>G	uc003pga.2	+	20	3257	c.3180C>G	c.(3178-3180)CAC>CAG	p.H1060Q	RIMS1_uc011dyb.1_Intron|RIMS1_uc003pgc.2_Intron|RIMS1_uc010kaq.2_Intron|RIMS1_uc011dyc.1_Intron|RIMS1_uc010kar.2_Intron|RIMS1_uc011dyd.1_Intron|RIMS1_uc003pgf.2_Intron|RIMS1_uc003pgg.2_Intron|RIMS1_uc003pgi.2_Intron|RIMS1_uc003pgh.2_Intron|RIMS1_uc003pgd.2_Missense_Mutation_p.H277Q|RIMS1_uc003pge.2_Intron|RIMS1_uc011dye.1_Intron|RIMS1_uc011dyf.1_Intron|RIMS1_uc010kas.1_Intron	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1060					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GCAGTTCTCACTGGAATATTT	0.383													3	7	---	---	---	---	PASS
KHDC1	80759	broad.mit.edu	37	6	73951416	73951416	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:73951416G>C	uc003pgo.2	-	5	1051	c.550C>G	c.(550-552)CTG>GTG	p.L184V	KHDC1_uc011dyl.1_Intron|KHDC1_uc003pgn.3_Missense_Mutation_p.L111V	NM_030568	NP_085045	Q4VXA5	KHDC1_HUMAN	KH homology domain containing 1	184						integral to membrane	RNA binding			skin(1)	1						TCGTTGGTCAGAGGCTGGCTT	0.567													6	65	---	---	---	---	PASS
CNR1	1268	broad.mit.edu	37	6	88854319	88854319	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:88854319C>T	uc011dzq.1	-	2	4238	c.675G>A	c.(673-675)AAG>AAA	p.K225K	CNR1_uc010kbz.2_Silent_p.K225K|CNR1_uc011dzr.1_Silent_p.K225K|CNR1_uc011dzs.1_Silent_p.K225K|CNR1_uc003pmq.3_Silent_p.K225K|CNR1_uc011dzt.1_Silent_p.K225K|CNR1_uc010kca.2_Silent_p.K192K	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	225	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	TGACAATCCTCTTATAGGCCA	0.597													10	17	---	---	---	---	PASS
ASCC3	10973	broad.mit.edu	37	6	101103640	101103640	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:101103640T>C	uc003pqk.2	-	17	3087	c.2758A>G	c.(2758-2760)ACT>GCT	p.T920A	ASCC3_uc011eai.1_Missense_Mutation_p.T822A	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	920					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TAAAGATAAGTGTAACTTATC	0.333													5	16	---	---	---	---	PASS
LAMA4	3910	broad.mit.edu	37	6	112463333	112463333	+	Silent	SNP	G	A	A	rs35772073	byFrequency	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:112463333G>A	uc003pvu.2	-	20	2964	c.2655C>T	c.(2653-2655)CTC>CTT	p.L885L	LAMA4_uc003pvv.2_Silent_p.L878L|LAMA4_uc003pvt.2_Silent_p.L878L	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	885	Laminin G-like 1.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TTTTGCTTCCGAGGTACAGGA	0.453													23	48	---	---	---	---	PASS
GJA1	2697	broad.mit.edu	37	6	121767995	121767995	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:121767995T>A	uc003pyr.2	+	2	252	c.2T>A	c.(1-3)ATG>AAG	p.M1K	GJA1_uc011ebo.1_5'UTR|GJA1_uc011ebp.1_5'UTR	NM_000165	NP_000156	P17302	CXA1_HUMAN	connexin 43	1					cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			ovary(2)	2				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	CCAGGCAACATGGGTGACTGG	0.443													48	68	---	---	---	---	PASS
C6orf58	352999	broad.mit.edu	37	6	127901587	127901587	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:127901587T>C	uc003qbh.2	+	3	578	c.566T>C	c.(565-567)TTT>TCT	p.F189S		NM_001010905	NP_001010905	Q6P5S2	CF058_HUMAN	hypothetical protein LOC352999 precursor	189						extracellular region					0				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		TGGAACACCTTTTACCAGGTT	0.378													7	17	---	---	---	---	PASS
L3MBTL3	84456	broad.mit.edu	37	6	130363886	130363886	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:130363886T>A	uc003qbt.2	+	3	212	c.42T>A	c.(40-42)GAT>GAA	p.D14E	L3MBTL3_uc003qbu.2_Missense_Mutation_p.D14E	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	14					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		AAGAGTTTGATGTGTTCAGTG	0.388													11	24	---	---	---	---	PASS
PHACTR2	9749	broad.mit.edu	37	6	144093534	144093534	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:144093534G>T	uc003qjq.3	+	7	1469	c.1339G>T	c.(1339-1341)GGG>TGG	p.G447W	PHACTR2_uc010khh.2_Missense_Mutation_p.G367W|PHACTR2_uc010khi.2_Missense_Mutation_p.G458W|PHACTR2_uc003qjr.3_Missense_Mutation_p.G378W	NM_014721	NP_055536	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2 isoform 3	447							actin binding|protein phosphatase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		TGACTCGGACGGGCCTATCTT	0.517													8	15	---	---	---	---	PASS
UTRN	7402	broad.mit.edu	37	6	144768768	144768768	+	Nonsense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:144768768C>T	uc003qkt.2	+	15	1845	c.1753C>T	c.(1753-1755)CAA>TAA	p.Q585*	UTRN_uc010khq.1_Nonsense_Mutation_p.Q585*	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	585	Interaction with SYNM.|Spectrin 4.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AATGAAGCGTCAAACATTGGA	0.388													23	59	---	---	---	---	PASS
SYNE1	23345	broad.mit.edu	37	6	152642923	152642923	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:152642923A>T	uc010kiw.2	-	83	16618	c.16016T>A	c.(16015-16017)GTT>GAT	p.V5339D	SYNE1_uc003qot.3_Missense_Mutation_p.V5268D|SYNE1_uc003qou.3_Missense_Mutation_p.V5339D|SYNE1_uc010kiz.2_Missense_Mutation_p.V1094D	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5339	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CGTTTCCTGAACCCAACATTT	0.398										HNSCC(10;0.0054)			12	26	---	---	---	---	PASS
IGF2R	3482	broad.mit.edu	37	6	160491005	160491005	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:160491005T>A	uc003qta.2	+	31	4506	c.4358T>A	c.(4357-4359)CTG>CAG	p.L1453Q		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1453	10.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		ATAATTGTCCTGAAATACGTT	0.557													11	9	---	---	---	---	PASS
PDE10A	10846	broad.mit.edu	37	6	165752791	165752791	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr6:165752791C>T	uc003qun.2	-	21	2365	c.2124G>A	c.(2122-2124)AAG>AAA	p.K708K	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Silent_p.K638K|PDE10A_uc003quo.2_Silent_p.K718K	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	708					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CTTCATCCTTCTTGTCTCTGT	0.353													7	36	---	---	---	---	PASS
PAPOLB	56903	broad.mit.edu	37	7	4900374	4900374	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:4900374C>A	uc003snk.2	-	1	1252	c.1068G>T	c.(1066-1068)AAG>AAT	p.K356N	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	355					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		ACCACTCTGCCTTACTTAGCA	0.403													35	38	---	---	---	---	PASS
ISPD	729920	broad.mit.edu	37	7	16341084	16341084	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:16341084T>C	uc010ktx.2	-	5	797	c.797A>G	c.(796-798)TAC>TGC	p.Y266C	ISPD_uc010kty.2_Missense_Mutation_p.Y216C	NM_001101426	NP_001094896	A4D126	ISPD_HUMAN	notch1-induced protein isoform a	266					isoprenoid biosynthetic process		nucleotidyltransferase activity			ovary(1)	1						ATCTCGTTTGTAGGTCACCTA	0.383										Multiple Myeloma(15;0.18)			16	11	---	---	---	---	PASS
DNAH11	8701	broad.mit.edu	37	7	21892087	21892087	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:21892087G>T	uc003svc.2	+	68	10951	c.10920G>T	c.(10918-10920)TTG>TTT	p.L3640F		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3640	AAA 5 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TTTATTAGTTGGTATTGACAA	0.294									Kartagener_syndrome				4	36	---	---	---	---	PASS
DBNL	28988	broad.mit.edu	37	7	44100498	44100498	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:44100498G>A	uc003tjp.3	+	13	1374	c.1276G>A	c.(1276-1278)GTG>ATG	p.V426M	DBNL_uc003tjo.3_Missense_Mutation_p.V427M|DBNL_uc003tjr.3_Missense_Mutation_p.V299M|DBNL_uc003tjq.3_Missense_Mutation_p.V435M|DBNL_uc011kbm.1_Missense_Mutation_p.V402M|DBNL_uc011kbn.1_Missense_Mutation_p.V323M|DBNL_uc011kbo.1_Missense_Mutation_p.V327M|DBNL_uc011kbp.1_Missense_Mutation_p.V378M|DBNL_uc011kbq.1_Missense_Mutation_p.V351M|DBNL_uc011kbr.1_Missense_Mutation_p.V375M|DBNL_uc011kbs.1_Missense_Mutation_p.V331M	NM_001014436	NP_001014436	Q9UJU6	DBNL_HUMAN	drebrin-like isoform b	426	SH3.				activation of JUN kinase activity|cellular component disassembly involved in apoptosis|endocytosis|Rac protein signal transduction	cell cortex|cytoskeleton|cytosol|lamellipodium	actin binding|enzyme activator activity|identical protein binding			skin(1)	1						TGCCAACTACGTGGAGCTCAT	0.577													11	22	---	---	---	---	PASS
AEBP1	165	broad.mit.edu	37	7	44153224	44153224	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:44153224C>A	uc003tkb.2	+	21	3146	c.2841C>A	c.(2839-2841)AAC>AAA	p.N947K	AEBP1_uc003tkc.3_Missense_Mutation_p.N522K|AEBP1_uc003tkd.2_Missense_Mutation_p.N197K	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	947	Interaction with PTEN (By similarity).|Required for transcriptional repression (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GAATCTTGAACCCGGGTGAGT	0.512													4	38	---	---	---	---	PASS
ADCY1	107	broad.mit.edu	37	7	45697428	45697428	+	Silent	SNP	C	T	T	rs142228376	byFrequency	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:45697428C>T	uc003tne.3	+	6	1269	c.1251C>T	c.(1249-1251)GAC>GAT	p.D417D	ADCY1_uc003tnd.2_Silent_p.D192D	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	417	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GGCAGTACGACGTGTGGTCCA	0.627													9	13	---	---	---	---	PASS
ZNF479	90827	broad.mit.edu	37	7	57188613	57188613	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:57188613G>T	uc010kzo.2	-	5	780	c.509C>A	c.(508-510)TCA>TAA	p.S170*		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			ATTGGAATTTGAAAATTTACC	0.299													11	20	---	---	---	---	PASS
PCLO	27445	broad.mit.edu	37	7	82579540	82579540	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:82579540C>T	uc003uhx.2	-	6	10653	c.10364G>A	c.(10363-10365)CGG>CAG	p.R3455Q	PCLO_uc003uhv.2_Missense_Mutation_p.R3455Q|PCLO_uc010lec.2_Missense_Mutation_p.R420Q	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3386					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CACATAGCTCCGATCTGTGGC	0.428													28	38	---	---	---	---	PASS
ABCB4	5244	broad.mit.edu	37	7	87053341	87053341	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:87053341G>A	uc003uiv.1	-	17	2168	c.2092C>T	c.(2092-2094)CTG>TTG	p.L698L	ABCB4_uc003uiw.1_Silent_p.L698L|ABCB4_uc003uix.1_Silent_p.L698L	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	698	Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					AGGACCTTCAGAAAGGACACT	0.398													43	64	---	---	---	---	PASS
SAMD9	54809	broad.mit.edu	37	7	92733928	92733928	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:92733928T>G	uc003umf.2	-	3	1739	c.1483A>C	c.(1483-1485)AAT>CAT	p.N495H	SAMD9_uc003umg.2_Missense_Mutation_p.N495H	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	495						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			AACCTGCCATTGCAGAAAATC	0.383													18	38	---	---	---	---	PASS
PON1	5444	broad.mit.edu	37	7	95025658	95025658	+	Missense_Mutation	SNP	C	G	G	rs146627952	byFrequency	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:95025658C>G	uc011kih.1	-	1	30	c.5G>C	c.(4-6)GGG>GCG	p.G2A	PON3_uc003unt.2_Missense_Mutation_p.G2A|PON3_uc011kii.1_Missense_Mutation_p.G2A			P27169	PON1_HUMAN	SubName: Full=cDNA FLJ57644, highly similar to Serum paraoxonase/arylesterase 1 (EC 3.1.1.2);	2					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	CACGAGCTTCCCCATGGTCTC	0.701													16	34	---	---	---	---	PASS
OCM2	4951	broad.mit.edu	37	7	97619402	97619402	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:97619402G>T	uc003upc.2	-	1	15	c.15C>A	c.(13-15)GAC>GAA	p.D5E		NM_006188	NP_006179	P0CE71	OCM2_HUMAN	oncomodulin-like	5							calcium ion binding				0						CACTGAGCACGTCCGTGATGC	0.557													14	44	---	---	---	---	PASS
ZAN	7455	broad.mit.edu	37	7	100346014	100346014	+	Silent	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:100346014G>T	uc003uwj.2	+	11	1335	c.1170G>T	c.(1168-1170)GGG>GGT	p.G390G	ZAN_uc003uwk.2_Silent_p.G390G|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	390	MAM 3.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AGACTTCCGGGGATGGTGGAC	0.542													28	25	---	---	---	---	PASS
MUC17	140453	broad.mit.edu	37	7	100683043	100683043	+	Silent	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:100683043C>A	uc003uxp.1	+	3	8399	c.8346C>A	c.(8344-8346)GTC>GTA	p.V2782V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2782	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|45.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GCATACCTGTCACCACTTCTA	0.473													65	197	---	---	---	---	PASS
CADPS2	93664	broad.mit.edu	37	7	122047709	122047709	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:122047709C>A	uc010lkp.2	-	19	2794	c.2631G>T	c.(2629-2631)GAG>GAT	p.E877D	CADPS2_uc011knx.1_Missense_Mutation_p.E252D|CADPS2_uc003vkg.3_Missense_Mutation_p.E571D|CADPS2_uc010lkq.2_Missense_Mutation_p.E871D	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	877	Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						CCCAAAATTTCTCTGCATGTT	0.383													15	25	---	---	---	---	PASS
TAS2R16	50833	broad.mit.edu	37	7	122635373	122635373	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:122635373T>C	uc003vkl.1	-	1	382	c.316A>G	c.(316-318)AAG>GAG	p.K106E		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	106	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						GAAGAGACCTTGATGCAGTAG	0.378													18	39	---	---	---	---	PASS
METTL2B	55798	broad.mit.edu	37	7	128141953	128141953	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:128141953C>G	uc003vnf.2	+	9	1157	c.1120C>G	c.(1120-1122)CTG>GTG	p.L374V	METTL2B_uc003vng.2_Missense_Mutation_p.L309V|METTL2B_uc011kop.1_Missense_Mutation_p.L238V	NM_018396	NP_060866	Q6P1Q9	MTL2B_HUMAN	methyltransferase like 2B	374							methyltransferase activity			skin(1)	1						CAAGCCCCTTCTGTCCAGCAC	0.458													59	108	---	---	---	---	PASS
FAM71F1	84691	broad.mit.edu	37	7	128359064	128359064	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:128359064C>G	uc003vno.1	+	3	667	c.614C>G	c.(613-615)ACC>AGC	p.T205S	FAM71F1_uc010llo.1_Missense_Mutation_p.T106S|FAM71F1_uc011koq.1_Missense_Mutation_p.T97S|FAM71F1_uc003vnm.1_RNA|FAM71F1_uc003vnn.1_Missense_Mutation_p.T106S|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Missense_Mutation_p.T205S	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	205										skin(1)	1						TCCATCACCACCAAAGACCCT	0.507													34	74	---	---	---	---	PASS
PLXNA4	91584	broad.mit.edu	37	7	131864554	131864554	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:131864554C>A	uc003vra.3	-	20	3995	c.3766G>T	c.(3766-3768)GTG>TTG	p.V1256L		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1256	Helical; (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GCAATGAGCACGGCCACGATG	0.622													6	11	---	---	---	---	PASS
ZNF746	155061	broad.mit.edu	37	7	149191588	149191588	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:149191588G>A	uc003wfw.2	-	2	302	c.31C>T	c.(31-33)CCG>TCG	p.P11S	ZNF746_uc010lpi.2_Missense_Mutation_p.P11S	NM_152557	NP_689770	Q6NUN9	ZN746_HUMAN	zinc finger protein 746 isoform 2	11					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|breast(1)	3	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			ATCGTCCACGGAGAAATCTTT	0.547													21	53	---	---	---	---	PASS
GIMAP8	155038	broad.mit.edu	37	7	150171512	150171512	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:150171512G>C	uc003whj.2	+	4	1425	c.1095G>C	c.(1093-1095)AGG>AGC	p.R365S		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	365						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		TTCTTACCAGGAAAGAAGATT	0.383													46	85	---	---	---	---	PASS
GALNTL5	168391	broad.mit.edu	37	7	151699823	151699823	+	Missense_Mutation	SNP	G	T	T	rs149988530		TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:151699823G>T	uc003wkp.2	+	6	906	c.683G>T	c.(682-684)AGC>ATC	p.S228I	GALNTL5_uc003wkq.2_5'UTR|GALNTL5_uc003wkr.2_RNA|GALNTL5_uc003wks.2_RNA|GALNTL5_uc010lqf.2_Missense_Mutation_p.S117I	NM_145292	NP_660335	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	228	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		TTCCTGGACAGCCACTGTGAG	0.502													15	19	---	---	---	---	PASS
PTPRN2	5799	broad.mit.edu	37	7	157926395	157926395	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:157926395C>T	uc003wno.2	-	9	1651	c.1530G>A	c.(1528-1530)GCG>GCA	p.A510A	PTPRN2_uc003wnp.2_Silent_p.A493A|PTPRN2_uc003wnq.2_Silent_p.A510A|PTPRN2_uc003wnr.2_Silent_p.A472A|PTPRN2_uc011kwa.1_Silent_p.A533A	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	510	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TGTAGCCCCGCGCCTCTTCCT	0.662													23	42	---	---	---	---	PASS
EPB49	2039	broad.mit.edu	37	8	21937755	21937755	+	Silent	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:21937755G>C	uc011kyt.1	+	11	1129	c.900G>C	c.(898-900)CGG>CGC	p.R300R	EPB49_uc010ltl.2_Silent_p.R300R|EPB49_uc011kys.1_Silent_p.R260R|EPB49_uc010ltn.2_Silent_p.R275R|EPB49_uc011kyu.1_Silent_p.R300R|EPB49_uc011kyv.1_Silent_p.R300R|EPB49_uc010ltq.2_Silent_p.R300R	NM_001114136	NP_001107608	Q08495	DEMA_HUMAN	erythrocyte membrane protein band 4.9 isoform 1	300	Interaction with RASGRF2.				actin filament bundle assembly|actin filament capping	actin cytoskeleton|nucleus	actin binding			central_nervous_system(1)	1				Colorectal(74;9.05e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0631)		CCCTGAGCCGGGTAAGGTCTC	0.587													39	47	---	---	---	---	PASS
NRG1	3084	broad.mit.edu	37	8	32463185	32463185	+	Silent	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:32463185C>A	uc003xiv.2	+	3	901	c.384C>A	c.(382-384)ACC>ACA	p.T128T	NRG1_uc003xip.2_Silent_p.T343T|NRG1_uc003xir.2_Silent_p.T128T|NRG1_uc010lvl.2_Silent_p.T128T|NRG1_uc010lvm.2_Silent_p.T128T|NRG1_uc010lvn.2_Silent_p.T128T|NRG1_uc003xis.2_Silent_p.T128T|NRG1_uc011lbf.1_Silent_p.T128T|NRG1_uc010lvo.2_Silent_p.T128T|NRG1_uc003xiu.2_Silent_p.T128T|NRG1_uc003xiw.2_Silent_p.T128T|NRG1_uc003xit.2_Silent_p.T128T|NRG1_uc010lvr.2_5'UTR|NRG1_uc010lvs.2_5'UTR|NRG1_uc010lvp.2_Silent_p.T94T|NRG1_uc010lvq.2_Silent_p.T94T|NRG1_uc003xix.2_Silent_p.T18T	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	128	Extracellular (Potential).|Ig-like C2-type.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		CCAATATCACCATCGTGGAAT	0.403													5	64	---	---	---	---	PASS
C8orf22	492307	broad.mit.edu	37	8	49985441	49985441	+	Nonsense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:49985441C>T	uc003xqq.3	+	2	235	c.52C>T	c.(52-54)CGA>TGA	p.R18*		NM_001007176	NP_001007177	Q8WWR9	PDPFL_HUMAN	hypothetical protein LOC492307	18											0		all_cancers(86;0.0452)|all_epithelial(80;0.000863)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				TCAGTATTATCGAAGTAAGTT	0.413													69	69	---	---	---	---	PASS
PCMTD1	115294	broad.mit.edu	37	8	52773466	52773466	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:52773466C>G	uc003xqx.3	-	2	587	c.246G>C	c.(244-246)TTG>TTC	p.L82F	PCMTD1_uc003xqw.3_Missense_Mutation_p.L82F|PCMTD1_uc011ldn.1_Intron|PCMTD1_uc010lya.2_Intron|PCMTD1_uc011ldo.1_Missense_Mutation_p.L82F	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	82						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				TAAGAAAAGACAATCCTGGTT	0.328													25	23	---	---	---	---	PASS
C8orf34	116328	broad.mit.edu	37	8	69699678	69699678	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:69699678G>C	uc010lyz.2	+	12	1247	c.1198G>C	c.(1198-1200)GAT>CAT	p.D400H	C8orf34_uc003xyb.2_Missense_Mutation_p.D375H	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	400					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			TCTTTTGCAGGATGAATCCTT	0.348													8	22	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77776369	77776369	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:77776369G>T	uc003yav.2	+	11	10671	c.10284G>T	c.(10282-10284)GAG>GAT	p.E3428D		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3424						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGCACAAAGAGAAAACAATCA	0.448										HNSCC(33;0.089)			53	55	---	---	---	---	PASS
ZFAND1	79752	broad.mit.edu	37	8	82630427	82630427	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:82630427C>T	uc003ycj.1	-	2	102	c.88G>A	c.(88-90)GGA>AGA	p.G30R	ZFAND1_uc010lzx.1_Missense_Mutation_p.G30R|ZFAND1_uc003yck.1_5'UTR	NM_024699	NP_078975	Q8TCF1	ZFAN1_HUMAN	zinc finger, AN1-type domain 1	30	AN1-type 1.						zinc ion binding			ovary(1)	1						CAAAATATTCCTGAACAATCA	0.264													10	36	---	---	---	---	PASS
DCAF4L2	138009	broad.mit.edu	37	8	88885761	88885761	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:88885761C>A	uc003ydz.2	-	1	536	c.439G>T	c.(439-441)GTG>TTG	p.V147L		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	147										ovary(1)	1						GCAAGTCCCACGAAGCACAGC	0.542													43	28	---	---	---	---	PASS
DCAF4L2	138009	broad.mit.edu	37	8	88885967	88885967	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:88885967A>G	uc003ydz.2	-	1	330	c.233T>C	c.(232-234)CTG>CCG	p.L78P		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	78										ovary(1)	1						GGTATTCGCCAGTATGCGGTT	0.542													52	54	---	---	---	---	PASS
EIF3E	3646	broad.mit.edu	37	8	109226865	109226865	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:109226865G>A	uc003ymu.2	-	10	1060	c.1032C>T	c.(1030-1032)TTC>TTT	p.F344F	EIF3E_uc003ymt.2_Silent_p.F295F|EIF3E_uc003ymv.2_Silent_p.F251F|EIF3E_uc010mci.1_Intron	NM_001568	NP_001559	P60228	EIF3E_HUMAN	eukaryotic translation initiation factor 3,	344	PCI.				negative regulation of translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|eukaryotic translation initiation factor 3 complex|PML body	protein N-terminus binding			ovary(2)|kidney(1)	3			OV - Ovarian serous cystadenocarcinoma(57;6.84e-10)			GGATGCGACAGAAAGTCTCAA	0.353													31	36	---	---	---	---	PASS
CSMD3	114788	broad.mit.edu	37	8	113240998	113240998	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:113240998G>A	uc003ynu.2	-	70	11110	c.10951C>T	c.(10951-10953)CTT>TTT	p.L3651F	CSMD3_uc003yns.2_Missense_Mutation_p.L2853F|CSMD3_uc003ynt.2_Missense_Mutation_p.L3611F|CSMD3_uc011lhx.1_Missense_Mutation_p.L3482F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3651	Helical; (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGTTTATAAAGATAAAATCCA	0.299										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			21	29	---	---	---	---	PASS
CSMD3	114788	broad.mit.edu	37	8	113240999	113240999	+	Nonsense_Mutation	SNP	A	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:113240999A>T	uc003ynu.2	-	70	11109	c.10950T>A	c.(10948-10950)TAT>TAA	p.Y3650*	CSMD3_uc003yns.2_Nonsense_Mutation_p.Y2852*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.Y3610*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.Y3481*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3650	Helical; (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GTTTATAAAGATAAAATCCAA	0.303										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			23	28	---	---	---	---	PASS
CSMD3	114788	broad.mit.edu	37	8	113564935	113564935	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:113564935G>A	uc003ynu.2	-	26	4408	c.4249C>T	c.(4249-4251)CGT>TGT	p.R1417C	CSMD3_uc003yns.2_Missense_Mutation_p.R689C|CSMD3_uc003ynt.2_Missense_Mutation_p.R1377C|CSMD3_uc011lhx.1_Missense_Mutation_p.R1313C	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1417	Extracellular (Potential).|CUB 8.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCTTTAAAACGACCTCCACAT	0.353										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	45	---	---	---	---	PASS
ZHX2	22882	broad.mit.edu	37	8	123965654	123965654	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:123965654A>G	uc003ypk.1	+	3	2471	c.1904A>G	c.(1903-1905)AAA>AGA	p.K635R		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	635	Homeobox 4.					cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			GCAATTGCAAAAAGTCAAGAA	0.567													22	78	---	---	---	---	PASS
ADCY8	114	broad.mit.edu	37	8	131812772	131812772	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:131812772G>T	uc003ytd.3	-	15	3216	c.2960C>A	c.(2959-2961)TCC>TAC	p.S987Y	ADCY8_uc010mds.2_Missense_Mutation_p.S856Y	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	987	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TCCTGGGATGGAGGCAAACAT	0.493										HNSCC(32;0.087)			61	58	---	---	---	---	PASS
FAM135B	51059	broad.mit.edu	37	8	139160773	139160773	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:139160773A>T	uc003yuy.2	-	14	3609	c.3438T>A	c.(3436-3438)CAT>CAA	p.H1146Q	FAM135B_uc003yux.2_Missense_Mutation_p.H1047Q|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.H708Q|FAM135B_uc003yvb.2_Missense_Mutation_p.W674R	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1146										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CATCCAGGCCATGGACACAGA	0.348										HNSCC(54;0.14)			26	24	---	---	---	---	PASS
BAI1	575	broad.mit.edu	37	8	143624780	143624780	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr8:143624780A>G	uc003ywm.2	+	28	4613	c.4430A>G	c.(4429-4431)TAT>TGT	p.Y1477C		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1477	Cytoplasmic (Potential).|Necessary for interaction with MAGI1.				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					AAGTCGCGGTATGCAGAACTG	0.632													13	19	---	---	---	---	PASS
KIAA1432	57589	broad.mit.edu	37	9	5770270	5770270	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr9:5770270C>G	uc003zji.2	+	22	3464	c.3371C>G	c.(3370-3372)TCT>TGT	p.S1124C	KIAA1432_uc003zjl.3_Missense_Mutation_p.S1087C|ERMP1_uc011lme.1_Intron	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	1203						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TCACCTTTATCTAATAAAGGT	0.393													9	65	---	---	---	---	PASS
TYRP1	7306	broad.mit.edu	37	9	12695754	12695754	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr9:12695754G>T	uc003zkv.3	+	3	803	c.625G>T	c.(625-627)GGT>TGT	p.G209C		NM_000550	NP_000541	P17643	TYRP1_HUMAN	tyrosinase-related protein 1 precursor	209	Lumenal, melanosome (Potential).				melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity			lung(1)	1		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)		GGAAAGCTTTGGTGAAGTGGA	0.433									Oculocutaneous_Albinism				4	47	---	---	---	---	PASS
BNC2	54796	broad.mit.edu	37	9	16436420	16436420	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr9:16436420G>T	uc003zml.2	-	6	1912	c.1772C>A	c.(1771-1773)ACC>AAC	p.T591N	BNC2_uc011lmw.1_Missense_Mutation_p.T496N|BNC2_uc003zmm.2_Missense_Mutation_p.T549N|BNC2_uc003zmq.1_Missense_Mutation_p.T605N|BNC2_uc003zmr.1_Missense_Mutation_p.T628N|BNC2_uc003zmp.1_Missense_Mutation_p.T619N|BNC2_uc010mij.1_Missense_Mutation_p.T513N|BNC2_uc011lmv.1_Missense_Mutation_p.T417N|BNC2_uc003zmo.1_Missense_Mutation_p.T513N|BNC2_uc003zmj.2_Missense_Mutation_p.T356N|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.T356N|BNC2_uc003zmn.1_Missense_Mutation_p.T356N	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	591	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		GATGGGACTGGTTGGGAGGGA	0.527													44	25	---	---	---	---	PASS
KLHL9	55958	broad.mit.edu	37	9	21333994	21333994	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr9:21333994C>T	uc003zoy.2	-	1	1436	c.865G>A	c.(865-867)GAT>AAT	p.D289N	KLHL9_uc003zow.2_Intron|KLHL9_uc003zox.2_RNA	NM_018847	NP_061335	Q9P2J3	KLHL9_HUMAN	kelch-like 9	289					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				ovary(3)|skin(1)	4				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		GCAGTTCTATCTGACTGCATC	0.423													7	56	---	---	---	---	PASS
UBAP2	55833	broad.mit.edu	37	9	33923422	33923422	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr9:33923422G>T	uc003ztq.1	-	25	2964	c.2851C>A	c.(2851-2853)CCC>ACC	p.P951T	UBAP2_uc011loc.1_Missense_Mutation_p.P860T|UBAP2_uc011lod.1_Missense_Mutation_p.P684T|UBAP2_uc011loe.1_Missense_Mutation_p.P706T|UBAP2_uc011lof.1_Missense_Mutation_p.P876T|UBAP2_uc003ztn.1_Missense_Mutation_p.P190T|UBAP2_uc003zto.1_Missense_Mutation_p.P190T|UBAP2_uc003ztp.1_Missense_Mutation_p.P190T	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	951										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		TGCTGGAAGGGAGGTGTGGGA	0.587													7	209	---	---	---	---	PASS
CREB3	10488	broad.mit.edu	37	9	35736623	35736623	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr9:35736623G>A	uc003zxv.2	+	9	1469	c.1016G>A	c.(1015-1017)CGA>CAA	p.R339Q	CREB3_uc010mla.2_Missense_Mutation_p.R258Q	NM_006368	NP_006359	O43889	CREB3_HUMAN	cAMP responsive element binding protein 3	363	Lumenal (Potential).|Pro-rich.				chemotaxis|induction of positive chemotaxis|interspecies interaction between organisms|negative regulation of cell cycle|positive regulation of calcium ion transport|positive regulation of cell migration|positive regulation of transcription, DNA-dependent|reactivation of latent virus|regulation of cell proliferation	cytosol|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|integral to membrane|nucleus|nucleus	cAMP response element binding protein binding|CCR1 chemokine receptor binding|DNA binding|protein dimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity				0	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)	GBM - Glioblastoma multiforme(74;0.0285)		CCTCTCTGCCGAGGTCCCATC	0.582											OREG0019176	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	126	---	---	---	---	PASS
ASTN2	23245	broad.mit.edu	37	9	119249690	119249690	+	Missense_Mutation	SNP	C	A	A	rs16933591	byFrequency	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr9:119249690C>A	uc004bjs.1	-	20	3546	c.3445G>T	c.(3445-3447)GTC>TTC	p.V1149F	ASTN2_uc004bjr.1_Missense_Mutation_p.V1145F|ASTN2_uc004bjt.1_Missense_Mutation_p.V1098F|ASTN2_uc004bjp.1_Missense_Mutation_p.V242F|ASTN2_uc004bjq.1_Missense_Mutation_p.V201F|ASTN2_uc011lxr.1_Missense_Mutation_p.V201F|ASTN2_uc011lxs.1_Missense_Mutation_p.V201F|ASTN2_uc011lxt.1_Missense_Mutation_p.V201F|ASTN2_uc004bjo.1_5'UTR	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	1149	Extracellular (Potential).|Fibronectin type-III.					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						TAGATACTGACTTCAGGGACC	0.507													40	58	---	---	---	---	PASS
ZNF79	7633	broad.mit.edu	37	9	130197393	130197393	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr9:130197393A>G	uc004bqw.3	+	3	544	c.130A>G	c.(130-132)ACG>GCG	p.T44A	ZNF79_uc011maf.1_Missense_Mutation_p.T20A|ZNF79_uc011mag.1_Missense_Mutation_p.T20A	NM_007135	NP_009066	Q15937	ZNF79_HUMAN	zinc finger protein 79	44	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						CAGCAGTGTGACGGTAGCTTT	0.512													39	18	---	---	---	---	PASS
MAN1B1	11253	broad.mit.edu	37	9	140002866	140002866	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr9:140002866C>T	uc004cld.2	+	13	1958	c.1923C>T	c.(1921-1923)ATC>ATT	p.I641I	MAN1B1_uc011mep.1_3'UTR|MAN1B1_uc010ncc.2_RNA|MAN1B1_uc004clf.1_Silent_p.I314I|MAN1B1_uc004clg.1_RNA	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase	641	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		ATTCTTCCATCAACAATGTCC	0.602													8	79	---	---	---	---	PASS
CACNA1B	774	broad.mit.edu	37	9	140773552	140773552	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr9:140773552G>A	uc004cog.2	+	2	476	c.331G>A	c.(331-333)GTG>ATG	p.V111M	uc004cof.1_Intron	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	111	Helical; Name=S1 of repeat I; (Potential).|I.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CAACTGCATCGTGCTGGCCCT	0.647													5	39	---	---	---	---	PASS
UPF2	26019	broad.mit.edu	37	10	12077311	12077311	+	Nonsense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:12077311T>A	uc001ila.2	-	1	586	c.112A>T	c.(112-114)AAA>TAA	p.K38*	UPF2_uc001ilb.2_Nonsense_Mutation_p.K38*|UPF2_uc001ilc.2_Nonsense_Mutation_p.K38*|UPF2_uc009xiz.1_Nonsense_Mutation_p.K38*	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	38	Glu/Lys-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				ATATCGTCTTTTGGCCTCTCC	0.453													49	52	---	---	---	---	PASS
ITGA8	8516	broad.mit.edu	37	10	15600177	15600177	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:15600177G>A	uc001ioc.1	-	26	2662	c.2662C>T	c.(2662-2664)CCT>TCT	p.P888S	ITGA8_uc010qcb.1_Missense_Mutation_p.P873S	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	888	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						CTGAGCTCAGGGGTGTCCTCT	0.458													14	17	---	---	---	---	PASS
CUBN	8029	broad.mit.edu	37	10	16873262	16873262	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:16873262G>A	uc001ioo.2	-	65	10569	c.10517C>T	c.(10516-10518)TCA>TTA	p.S3506L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3506	CUB 26.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGAGGGTGATGAAGTCCAGAT	0.368													5	48	---	---	---	---	PASS
GPR158	57512	broad.mit.edu	37	10	25886869	25886869	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:25886869G>A	uc001isj.2	+	11	2374	c.2314G>A	c.(2314-2316)GAG>AAG	p.E772K	GPR158_uc001isk.2_Missense_Mutation_p.E147K	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	772	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GTGCTCTAAAGAGGACAAGGA	0.572													13	117	---	---	---	---	PASS
GAD2	2572	broad.mit.edu	37	10	26569943	26569943	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:26569943A>T	uc001isp.2	+	12	1666	c.1163A>T	c.(1162-1164)AAC>ATC	p.N388I	GAD2_uc001isq.2_Missense_Mutation_p.N388I	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	388					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	TTTAGGGCCAACTCTGTGACG	0.498													34	64	---	---	---	---	PASS
APBB1IP	54518	broad.mit.edu	37	10	26830582	26830582	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:26830582G>A	uc001iss.2	+	11	1437	c.1116G>A	c.(1114-1116)ATG>ATA	p.M372I	APBB1IP_uc009xks.1_Missense_Mutation_p.M372I	NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	372	PH.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						AGCATAAAATGAAATATAAAG	0.303													9	26	---	---	---	---	PASS
KIAA1462	57608	broad.mit.edu	37	10	30318360	30318360	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:30318360C>T	uc001iux.2	-	2	776	c.717G>A	c.(715-717)GAG>GAA	p.E239E	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Silent_p.E101E|KIAA1462_uc009xle.1_Silent_p.E239E	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	239										ovary(4)	4						AACTCAGGCTCTCGGGGGAAA	0.458													34	68	---	---	---	---	PASS
ZNF37A	7587	broad.mit.edu	37	10	38407328	38407328	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:38407328G>A	uc001izk.2	+	8	2068	c.1249G>A	c.(1249-1251)GGG>AGG	p.G417R	ZNF37A_uc001izl.2_Missense_Mutation_p.G417R|ZNF37A_uc001izm.2_Missense_Mutation_p.G417R	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	417	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						TAATGAATGTGGGAAGTCATT	0.363													12	26	---	---	---	---	PASS
ZNF37A	7587	broad.mit.edu	37	10	38407329	38407329	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:38407329G>T	uc001izk.2	+	8	2069	c.1250G>T	c.(1249-1251)GGG>GTG	p.G417V	ZNF37A_uc001izl.2_Missense_Mutation_p.G417V|ZNF37A_uc001izm.2_Missense_Mutation_p.G417V	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	417	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						AATGAATGTGGGAAGTCATTC	0.368													13	25	---	---	---	---	PASS
C10orf72	196740	broad.mit.edu	37	10	50285339	50285339	+	Missense_Mutation	SNP	C	A	A	rs45489505	byFrequency	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:50285339C>A	uc001jhf.2	-	4	588	c.559G>T	c.(559-561)GTG>TTG	p.V187L		NM_001031746	NP_001026916	Q8IW00	CJ072_HUMAN	hypothetical protein LOC196740 isoform 1	187	Helical; (Potential).					integral to membrane|plasma membrane					0						AGGATCCCCACGCAGCACACG	0.522													12	29	---	---	---	---	PASS
CHAT	1103	broad.mit.edu	37	10	50824633	50824633	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:50824633C>T	uc001jhz.2	+	2	525	c.372C>T	c.(370-372)CCC>CCT	p.P124P	CHAT_uc001jhv.1_Silent_p.P6P|CHAT_uc001jhx.1_Silent_p.P6P|CHAT_uc001jhy.1_Silent_p.P6P|CHAT_uc001jia.2_Silent_p.P6P|CHAT_uc010qgs.1_Silent_p.P6P	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	124					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	CAAAAACTCCCAGCAGTGAGG	0.567													5	10	---	---	---	---	PASS
PCDH15	65217	broad.mit.edu	37	10	55569209	55569209	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:55569209T>C	uc010qhs.1	-	37	5011	c.4616A>G	c.(4615-4617)GAG>GGG	p.E1539G	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qht.1_Missense_Mutation_p.E1532G|PCDH15_uc010qhu.1_3'UTR	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GTATGTAGGCTCAGCTGCTGG	0.398										HNSCC(58;0.16)			35	45	---	---	---	---	PASS
PCDH15	65217	broad.mit.edu	37	10	55569211	55569211	+	Silent	SNP	A	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:55569211A>T	uc010qhs.1	-	37	5009	c.4614T>A	c.(4612-4614)GCT>GCA	p.A1538A	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qht.1_Silent_p.A1531A|PCDH15_uc010qhu.1_3'UTR	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ATGTAGGCTCAGCTGCTGGTG	0.393										HNSCC(58;0.16)			38	49	---	---	---	---	PASS
DDIT4	54541	broad.mit.edu	37	10	74034808	74034808	+	Silent	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:74034808C>G	uc001jsx.1	+	3	763	c.561C>G	c.(559-561)CCC>CCG	p.P187P		NM_019058	NP_061931	Q9NX09	DDIT4_HUMAN	RTP801	187					apoptosis					pancreas(1)	1						GACTCTGGCCCAAGATCCAGG	0.637											OREG0020262	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	13	---	---	---	---	PASS
CDHR1	92211	broad.mit.edu	37	10	85973009	85973009	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:85973009G>T	uc001kcv.2	+	16	1945	c.1945G>T	c.(1945-1947)GAC>TAC	p.D649Y	CDHR1_uc001kcw.2_Missense_Mutation_p.D649Y|CDHR1_uc009xst.2_Missense_Mutation_p.D353Y|CDHR1_uc001kcx.2_5'UTR	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	649	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						ACCTGGAAGGGACTGCCTATG	0.577													24	61	---	---	---	---	PASS
WAPAL	23063	broad.mit.edu	37	10	88260398	88260398	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:88260398G>C	uc001kdo.2	-	3	1044	c.602C>G	c.(601-603)GCT>GGT	p.A201G	WAPAL_uc001kdn.2_Missense_Mutation_p.A244G|WAPAL_uc009xsw.2_Missense_Mutation_p.A201G	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	201	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						GATTTCAGAAGCCACTGTAGT	0.373													24	36	---	---	---	---	PASS
LIPA	3988	broad.mit.edu	37	10	91005508	91005508	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:91005508G>T	uc001kga.3	-	3	322	c.154C>A	c.(154-156)CTA>ATA	p.L52I	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|LIPA_uc009xtq.2_Missense_Mutation_p.L52I	NM_000235	NP_000226	P38571	LICH_HUMAN	lipase A precursor	52					lipid catabolic process	lysosome	lipase activity|sterol esterase activity				0		Colorectal(252;0.0162)		GBM - Glioblastoma multiforme(2;0.00406)		GTCTCAACTAGGTATTCCTCA	0.418													4	34	---	---	---	---	PASS
LBX1	10660	broad.mit.edu	37	10	102987414	102987414	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:102987414G>A	uc001ksx.2	-	2	604	c.459C>T	c.(457-459)GCC>GCT	p.A153A	uc010qpy.1_5'Flank	NM_006562	NP_006553	P52954	LBX1_HUMAN	ladybird homeobox 1	153	Homeobox.				muscle organ development		sequence-specific DNA binding				0		Colorectal(252;0.234)		Epithelial(162;3.22e-09)|all cancers(201;1.79e-07)		GGTCGCGATCGGCGGGGGACA	0.582													10	68	---	---	---	---	PASS
SORCS3	22986	broad.mit.edu	37	10	106960916	106960916	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:106960916G>A	uc001kyi.1	+	16	2393	c.2166G>A	c.(2164-2166)AAG>AAA	p.K722K	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	722	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AAATATTCAAGAAACGTAAGC	0.478													16	34	---	---	---	---	PASS
C10orf96	374355	broad.mit.edu	37	10	118084555	118084555	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:118084555T>C	uc001lck.2	+	2	283	c.32T>C	c.(31-33)ATC>ACC	p.I11T		NM_198515	NP_940917	P0C7W6	CJ096_HUMAN	hypothetical protein LOC374355	11										ovary(2)	2		Lung NSC(174;0.204)|all_lung(145;0.248)		all cancers(201;0.014)		CAGCACATCATCTTCACCGAG	0.522													6	22	---	---	---	---	PASS
PNLIPRP3	119548	broad.mit.edu	37	10	118236315	118236315	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:118236315G>T	uc001lcl.3	+	11	1425	c.1324G>T	c.(1324-1326)GGG>TGG	p.G442W		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	442	PLAT.				lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		AAATACATCTGGGAAATATGG	0.303													11	22	---	---	---	---	PASS
HSPA12A	259217	broad.mit.edu	37	10	118440730	118440730	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:118440730G>A	uc001lct.2	-	9	1065	c.960C>T	c.(958-960)ACC>ACT	p.T320T	HSPA12A_uc001lcu.2_Silent_p.T237T	NM_025015	NP_079291	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	320							ATP binding			ovary(1)	1				all cancers(201;0.0158)		TCAGGTCTACGGTGCCACCGC	0.488													10	23	---	---	---	---	PASS
RGS10	6001	broad.mit.edu	37	10	121285580	121285580	+	Silent	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:121285580T>C	uc001lee.2	-	2	195	c.195A>G	c.(193-195)GCA>GCG	p.A65A	RGS10_uc001lef.2_Silent_p.A59A|RGS10_uc001leg.2_Silent_p.A73A	NM_002925	NP_002916	O43665	RGS10_HUMAN	regulator of G-protein signaling 10 isoform b	65	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|protein binding|signal transducer activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00105)|GBM - Glioblastoma multiforme(135;0.195)		AATCTTCACATGCTAGCCAAA	0.303													7	52	---	---	---	---	PASS
PWWP2B	170394	broad.mit.edu	37	10	134219163	134219163	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr10:134219163G>A	uc001lll.3	+	2	1188	c.1159G>A	c.(1159-1161)GAG>AAG	p.E387K	PWWP2B_uc009ybe.2_Missense_Mutation_p.E387K	NM_138499	NP_612508	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2 isoform 1	387											0		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		AAGTTCGGGTGAGGACGATGA	0.667													7	40	---	---	---	---	PASS
NLRP6	171389	broad.mit.edu	37	11	278571	278571	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:278571T>C	uc010qvs.1	+	1	2	c.2T>C	c.(1-3)ATG>ACG	p.M1T	NLRP6_uc010qvt.1_Missense_Mutation_p.M1T	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	1	DAPIN.					cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		AGAGACCCCATGGACCAGCCA	0.647													24	20	---	---	---	---	PASS
SIGIRR	59307	broad.mit.edu	37	11	408162	408162	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:408162C>T	uc001lpd.2	-	4	581	c.251G>A	c.(250-252)GGG>GAG	p.G84E	SIGIRR_uc001lpf.2_Missense_Mutation_p.G84E|SIGIRR_uc001lpe.1_Missense_Mutation_p.G84E|SIGIRR_uc001lpg.2_Missense_Mutation_p.G84E	NM_001135054	NP_001128526	Q6IA17	SIGIR_HUMAN	single Ig IL-1R-related molecule	84	Ig-like C2-type.|Extracellular (Potential).				acute-phase response|innate immune response|negative regulation of chemokine biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity	integral to membrane	protein binding|transmembrane receptor activity				0		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CACGTTGACCCCCAGGACACT	0.587													10	49	---	---	---	---	PASS
HRAS	3265	broad.mit.edu	37	11	534286	534286	+	Missense_Mutation	SNP	C	A	A	rs104894228		TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:534286C>A	uc001lpv.2	-	2	225	c.37G>T	c.(37-39)GGT>TGT	p.G13C	HRAS_uc010qvw.1_Missense_Mutation_p.G13C|HRAS_uc010qvx.1_Missense_Mutation_p.G13C|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	13	GTP.		G -> D (in FCSS).|G -> C (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G13R(34)|p.G13V(10)|p.G13D(9)|p.G13S(9)|p.G13C(6)|p.G13G(1)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TTGCCCACACCGCCGGCGCCC	0.642		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			13	7	---	---	---	---	PASS
KRTAP5-6	440023	broad.mit.edu	37	11	1718593	1718593	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:1718593T>G	uc001lua.2	+	1	169	c.118T>G	c.(118-120)TGC>GGC	p.C40G		NM_001012416	NP_001012416	Q6L8G9	KRA56_HUMAN	keratin associated protein 5-6	40	3.|6 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GCCCGTGTGCTGCTGTGTGCC	0.667													32	36	---	---	---	---	PASS
ART5	116969	broad.mit.edu	37	11	3660919	3660919	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:3660919C>A	uc001lyb.1	-	2	1133	c.740G>T	c.(739-741)TGG>TTG	p.W247L	ART5_uc001lyc.1_Missense_Mutation_p.W247L|ART5_uc001lyd.2_Intron|ART5_uc009yea.2_Intron	NM_053017	NP_443750	Q96L15	NAR5_HUMAN	ADP-ribosyltransferase 5 precursor	247						extracellular region	NAD(P)+-protein-arginine ADP-ribosyltransferase activity			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0336)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATTATAGCTCCAGAGAGTCAC	0.527													6	69	---	---	---	---	PASS
OR52E8	390079	broad.mit.edu	37	11	5878375	5878375	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:5878375C>A	uc010qzr.1	-	1	558	c.558G>T	c.(556-558)GAG>GAT	p.E186D	TRIM5_uc001mbq.1_Intron	NM_001005168	NP_001005168	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E,	186	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCCCATGTGCTCACAATAAG	0.483													5	58	---	---	---	---	PASS
OR52E4	390081	broad.mit.edu	37	11	5905533	5905533	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:5905533T>C	uc010qzs.1	+	1	11	c.11T>C	c.(10-12)ATC>ACC	p.I4T	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	4	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGCCTTCTATCAATGACACC	0.428													23	29	---	---	---	---	PASS
OR52B2	255725	broad.mit.edu	37	11	6190722	6190722	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:6190722C>A	uc010qzy.1	-	1	835	c.835G>T	c.(835-837)GCC>TCC	p.A279S		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	279	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAAAGATTGGCCAGCAAGATA	0.448													12	17	---	---	---	---	PASS
DCHS1	8642	broad.mit.edu	37	11	6655522	6655522	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:6655522C>T	uc001mem.1	-	3	2223	c.1813G>A	c.(1813-1815)GCG>ACG	p.A605T		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	605	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCACTATCCGCGTCTGTGGCT	0.572													13	14	---	---	---	---	PASS
HTATIP2	10553	broad.mit.edu	37	11	20398241	20398241	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:20398241A>G	uc009yia.1	+	4	485	c.419A>G	c.(418-420)AAT>AGT	p.N140S	HTATIP2_uc009yib.1_Missense_Mutation_p.N140S|HTATIP2_uc001mpx.2_Missense_Mutation_p.N174S|HTATIP2_uc001mpz.2_Missense_Mutation_p.N140S	NM_006410	NP_006401	Q9BUP3	HTAI2_HUMAN	HIV-1 Tat interactive protein 2, 30kDa isoform	140					angiogenesis|anti-apoptosis|apoptosis|cell differentiation|cellular amino acid metabolic process|induction of apoptosis|interspecies interaction between organisms|nuclear import|regulation of angiogenesis|regulation of transcription from RNA polymerase II promoter	cytoplasm|nuclear envelope	NAD binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|protein binding|transcription coactivator activity				0						AAATCAAGCAATTTTTTATAT	0.363													11	34	---	---	---	---	PASS
OR4X2	119764	broad.mit.edu	37	11	48267476	48267476	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:48267476T>C	uc001ngs.1	+	1	821	c.821T>C	c.(820-822)CTG>CCG	p.L274P		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	274	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACCGCGATCCTGAACCCTGTC	0.478													21	45	---	---	---	---	PASS
OR4S1	256148	broad.mit.edu	37	11	48328071	48328071	+	Silent	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:48328071C>G	uc010rhu.1	+	1	297	c.297C>G	c.(295-297)CTC>CTG	p.L99L		NM_001004725	NP_001004725	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S,	99	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGACCCAGCTCTTTTCTGCCC	0.493													3	49	---	---	---	---	PASS
OR4A15	81328	broad.mit.edu	37	11	55136005	55136005	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:55136005G>T	uc010rif.1	+	1	646	c.646G>T	c.(646-648)GCT>TCT	p.A216S		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	216	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATTGAAACTTGCTTGCACCAA	0.418													21	27	---	---	---	---	PASS
OR5D18	219438	broad.mit.edu	37	11	55587663	55587663	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:55587663C>T	uc010rin.1	+	1	558	c.558C>T	c.(556-558)CTC>CTT	p.L186L		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	186	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				CCTCACTACTCTCCCTTTCTT	0.408													19	58	---	---	---	---	PASS
ZFP91	80829	broad.mit.edu	37	11	58384716	58384716	+	Nonsense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:58384716G>A	uc001nmx.3	+	11	1418	c.1250G>A	c.(1249-1251)TGG>TAG	p.W417*	ZFP91_uc001nmy.3_Nonsense_Mutation_p.W416*|ZFP91-CNTF_uc010rkm.1_RNA	NM_053023	NP_444251	Q96JP5	ZFP91_HUMAN	zinc finger protein 91	417	C2H2-type 4.				activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				TCTCTTAATTGGCACATGAAG	0.413													14	38	---	---	---	---	PASS
OR5A1	219982	broad.mit.edu	37	11	59211431	59211431	+	Nonsense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:59211431C>T	uc001nnx.1	+	1	790	c.790C>T	c.(790-792)CGA>TGA	p.R264*		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						CGTGTACTTGCGACCCAGCTC	0.527													40	82	---	---	---	---	PASS
GANAB	23193	broad.mit.edu	37	11	62402444	62402444	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:62402444T>A	uc001nub.2	-	5	442	c.409A>T	c.(409-411)AGT>TGT	p.S137C	GANAB_uc001nua.2_Missense_Mutation_p.S137C|GANAB_uc001nuc.2_Missense_Mutation_p.S40C|GANAB_uc010rma.1_Missense_Mutation_p.S23C|GANAB_uc010rmb.1_Missense_Mutation_p.S23C	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	137					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						AACTCCACACTGTTCTCATCA	0.463													46	41	---	---	---	---	PASS
SLC22A12	116085	broad.mit.edu	37	11	64359261	64359261	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:64359261C>A	uc001oam.1	+	1	980	c.233C>A	c.(232-234)CCG>CAG	p.P78Q	SLC22A12_uc009ypr.1_Missense_Mutation_p.P78Q|SLC22A12_uc001oal.1_5'UTR|SLC22A12_uc009yps.1_Missense_Mutation_p.P78Q|SLC22A12_uc001oan.1_Missense_Mutation_p.P78Q|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	78					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						ATTTCCATCCCGCCGGGCCCC	0.692													8	11	---	---	---	---	PASS
KDM2A	22992	broad.mit.edu	37	11	66983395	66983395	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:66983395G>T	uc001ojw.2	+	8	1526	c.662G>T	c.(661-663)TGG>TTG	p.W221L	KDM2A_uc001ojx.2_RNA|KDM2A_uc001ojy.2_5'UTR	NM_012308	NP_036440	Q9Y2K7	KDM2A_HUMAN	F-box and leucine-rich repeat protein 11	221	JmjC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			ovary(4)|lung(3)|breast(1)|skin(1)	9						ACCTCTGTTTGGTATCACATC	0.428													6	164	---	---	---	---	PASS
MYEOV	26579	broad.mit.edu	37	11	69063118	69063118	+	Missense_Mutation	SNP	C	A	A	rs139486495		TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:69063118C>A	uc001oov.2	+	3	651	c.201C>A	c.(199-201)TTC>TTA	p.F67L	MYEOV_uc001oox.2_Intron|MYEOV_uc009ysl.2_Missense_Mutation_p.F67L|MYEOV_uc001oow.2_Missense_Mutation_p.F9L	NM_138768	NP_620123	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	67											0	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		CTGGACACTTCGTGGAGGGCT	0.582													4	50	---	---	---	---	PASS
PGM2L1	283209	broad.mit.edu	37	11	74062614	74062614	+	Nonsense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:74062614C>T	uc001ovb.1	-	6	859	c.563G>A	c.(562-564)TGG>TAG	p.W188*		NM_173582	NP_775853	Q6PCE3	PGM2L_HUMAN	phosphoglucomutase 2-like 1	188					glucose 1-phosphate metabolic process	cytosol	glucose-1,6-bisphosphate synthase activity|phosphoglucomutase activity			ovary(1)	1	Breast(11;3.32e-06)					ACCAGTTTCCCAGTAAACCTA	0.328													8	22	---	---	---	---	PASS
ODZ4	26011	broad.mit.edu	37	11	78380545	78380545	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:78380545T>A	uc001ozl.3	-	32	7308	c.6845A>T	c.(6844-6846)AAC>ATC	p.N2282I	ODZ4_uc001ozk.3_Missense_Mutation_p.N507I|ODZ4_uc009yvb.1_Missense_Mutation_p.N866I	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2282	Extracellular (Potential).|YD 21.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GCCAGCCCGGTTGTAGGCCTT	0.592													22	48	---	---	---	---	PASS
SYTL2	54843	broad.mit.edu	37	11	85415985	85415985	+	Silent	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:85415985T>C	uc010rth.1	-	14	2466	c.2190A>G	c.(2188-2190)CTA>CTG	p.L730L	SYTL2_uc010rtg.1_Silent_p.L731L|SYTL2_uc010rti.1_Silent_p.L706L|SYTL2_uc010rtj.1_Silent_p.L698L|SYTL2_uc001pav.2_Silent_p.L172L|SYTL2_uc010rte.1_Silent_p.L132L|SYTL2_uc001pax.2_Silent_p.L172L|SYTL2_uc001paz.2_Silent_p.L51L|SYTL2_uc001pba.2_Silent_p.L115L|SYTL2_uc001pay.2_Silent_p.L161L|SYTL2_uc001paw.2_Silent_p.L132L|SYTL2_uc009yvj.2_RNA|SYTL2_uc001pbd.2_Silent_p.L1028L|SYTL2_uc001pbb.2_Silent_p.L1068L|SYTL2_uc001pbc.2_Silent_p.L1052L|SYTL2_uc010rtf.1_Silent_p.L548L	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	730	C2 1.				intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		CCACCTCCCCTAGGAAACTAT	0.388													24	33	---	---	---	---	PASS
PICALM	8301	broad.mit.edu	37	11	85701428	85701428	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:85701428T>C	uc001pbm.2	-	13	1559	c.1273A>G	c.(1273-1275)ACT>GCT	p.T425A	PICALM_uc001pbl.2_Intron|PICALM_uc001pbn.2_Intron|PICALM_uc010rtl.1_Intron|PICALM_uc010rtk.1_Intron|PICALM_uc001pbo.1_Missense_Mutation_p.T57A	NM_007166	NP_009097	Q13492	PICAL_HUMAN	phosphatidylinositol-binding clathrin assembly	425					clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			urinary_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				GCATCTACAGTAGCAGAGAAA	0.338			T	MLLT10|MLL	TALL|AML|								6	19	---	---	---	---	PASS
EED	8726	broad.mit.edu	37	11	85988171	85988171	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:85988171C>A	uc001pbp.2	+	10	1573	c.1116C>A	c.(1114-1116)TTC>TTA	p.F372L	EED_uc010rtm.1_Missense_Mutation_p.F372L|EED_uc001pbq.2_Missense_Mutation_p.F372L|EED_uc001pbr.2_Missense_Mutation_p.F397L|EED_uc001pbs.2_Missense_Mutation_p.F292L|EED_uc010rtn.1_RNA	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	372	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.|WD 6.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				CTATGGATTTCTGGCAAAAGG	0.333													11	28	---	---	---	---	PASS
NAALAD2	10003	broad.mit.edu	37	11	89911209	89911209	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:89911209G>A	uc001pdf.3	+	16	1891	c.1782G>A	c.(1780-1782)TTG>TTA	p.L594L	NAALAD2_uc009yvx.2_Silent_p.L561L|NAALAD2_uc009yvy.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	594	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				CAGAAGCTTTGAAAAACTATG	0.338													26	32	---	---	---	---	PASS
ANGPTL5	253935	broad.mit.edu	37	11	101762074	101762074	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:101762074G>T	uc001pgl.2	-	9	1699	c.1103C>A	c.(1102-1104)TCA>TAA	p.S368*		NM_178127	NP_835228	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5 precursor	368	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		CTTGACAGGTGAGTTGTTTTT	0.333													23	47	---	---	---	---	PASS
EXPH5	23086	broad.mit.edu	37	11	108384542	108384542	+	Silent	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:108384542C>A	uc001pkk.2	-	6	1803	c.1692G>T	c.(1690-1692)GTG>GTT	p.V564V	EXPH5_uc010rvy.1_Silent_p.V376V|EXPH5_uc010rvz.1_Silent_p.V408V|EXPH5_uc010rwa.1_Silent_p.V488V	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	564					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CATGTGATACCACCATGCTAT	0.438													4	31	---	---	---	---	PASS
DSCAML1	57453	broad.mit.edu	37	11	117351887	117351887	+	Splice_Site	SNP	A	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:117351887A>T	uc001prh.1	-	13	2838	c.2836_splice	c.e13+1	p.E946_splice		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1						axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGGTGAAGGTACCTTGCACAG	0.627													6	23	---	---	---	---	PASS
KCNJ1	3758	broad.mit.edu	37	11	128709173	128709173	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:128709173G>T	uc001qeo.1	-	2	1074	c.1023C>A	c.(1021-1023)TTC>TTA	p.F341L	KCNJ1_uc001qep.1_Missense_Mutation_p.F322L|KCNJ1_uc001qeq.1_Missense_Mutation_p.F322L|KCNJ1_uc001qer.1_Missense_Mutation_p.F322L|KCNJ1_uc001qes.1_Missense_Mutation_p.F322L	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	341	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	TAAAGTTATGGAAATCCACTC	0.483													14	23	---	---	---	---	PASS
NTM	50863	broad.mit.edu	37	11	132016281	132016281	+	Silent	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:132016281G>T	uc001qgp.2	+	2	937	c.273G>T	c.(271-273)CTG>CTT	p.L91L	NTM_uc001qgm.2_Silent_p.L91L|NTM_uc010sch.1_Silent_p.L82L|NTM_uc010sci.1_Silent_p.L91L|NTM_uc010scj.1_Silent_p.L50L|NTM_uc001qgo.2_Silent_p.L91L|NTM_uc001qgq.2_Silent_p.L91L	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	91	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						TGGTCCTTCTGAGCAACACCC	0.567													22	43	---	---	---	---	PASS
NTM	50863	broad.mit.edu	37	11	132180054	132180054	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:132180054A>C	uc001qgp.2	+	5	1374	c.710A>C	c.(709-711)CAA>CCA	p.Q237P	NTM_uc001qgm.2_Missense_Mutation_p.Q237P|NTM_uc010sch.1_Missense_Mutation_p.Q228P|NTM_uc010sci.1_Missense_Mutation_p.Q237P|NTM_uc010scj.1_Missense_Mutation_p.Q196P|NTM_uc001qgo.2_Missense_Mutation_p.Q237P|NTM_uc001qgq.2_Missense_Mutation_p.Q237P|NTM_uc001qgr.2_5'UTR	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	237	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						CCCGTGGGACAAAAGGGGACA	0.483													42	83	---	---	---	---	PASS
B3GAT1	27087	broad.mit.edu	37	11	134253897	134253897	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr11:134253897C>T	uc001qhq.2	-	4	559	c.298G>A	c.(298-300)GCC>ACC	p.A100T	B3GAT1_uc001qhr.2_Missense_Mutation_p.A100T|B3GAT1_uc010scv.1_Missense_Mutation_p.A113T	NM_018644	NP_061114	Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1	100	Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)		GTCAGCTCGGCCTTCTGCACC	0.716													6	5	---	---	---	---	PASS
TULP3	7289	broad.mit.edu	37	12	3048522	3048522	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:3048522T>A	uc010seh.1	+	11	1322	c.1241T>A	c.(1240-1242)TTC>TAC	p.F414Y	TULP3_uc009zec.1_Missense_Mutation_p.F141Y|TULP3_uc010seg.1_RNA|TULP3_uc001qlj.2_Missense_Mutation_p.F414Y|TULP3_uc010sei.1_Missense_Mutation_p.F238Y	NM_003324	NP_003315	O75386	TULP3_HUMAN	tubby like protein 3 isoform 1	414					G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding				0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GATGACGTGTTCACACTGGAT	0.433													54	77	---	---	---	---	PASS
CHD4	1108	broad.mit.edu	37	12	6696922	6696922	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:6696922T>C	uc001qpo.2	-	24	3823	c.3659A>G	c.(3658-3660)AAA>AGA	p.K1220R	CHD4_uc001qpn.2_Missense_Mutation_p.K1213R|CHD4_uc001qpp.2_Missense_Mutation_p.K1217R	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1220					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						AGTGCCAAATTTGAGGATATC	0.493													24	32	---	---	---	---	PASS
CLEC1A	51267	broad.mit.edu	37	12	10224077	10224077	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:10224077C>T	uc001qxb.2	-	6	782	c.698G>A	c.(697-699)AGC>AAC	p.S233N	CLEC1A_uc009zhf.2_Missense_Mutation_p.S145N|CLEC1A_uc001qxc.2_Missense_Mutation_p.S145N|CLEC1A_uc001qxd.2_Missense_Mutation_p.S190N|CLEC1A_uc010sgx.1_Missense_Mutation_p.S131N	NM_016511	NP_057595	Q8NC01	CLC1A_HUMAN	C-type lectin-like receptor-1	233	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			ovary(1)|central_nervous_system(1)	2						ACAGTCTCTGCTTCTTGGGCT	0.383													33	83	---	---	---	---	PASS
PRB2	653247	broad.mit.edu	37	12	11546665	11546665	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:11546665C>G	uc010shk.1	-	3	382	c.347G>C	c.(346-348)GGA>GCA	p.G116A		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTGTGGCTTTCCTGGAGGAGA	0.597													10	372	---	---	---	---	PASS
GPRC5A	9052	broad.mit.edu	37	12	13061863	13061863	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:13061863G>T	uc001rba.2	+	2	1330	c.680G>T	c.(679-681)TGG>TTG	p.W227L	GPRC5A_uc001raz.2_Missense_Mutation_p.W227L	NM_003979	NP_003970	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5,	227	Helical; Name=6; (Potential).					cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	TGGGTGGCCTGGATCACCCTG	0.572													33	49	---	---	---	---	PASS
GRIN2B	2904	broad.mit.edu	37	12	13724888	13724888	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:13724888G>C	uc001rbt.2	-	10	2200	c.2021C>G	c.(2020-2022)CCT>CGT	p.P674R		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	674	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GAAGTCATTAGGTCTCTGGAA	0.323													10	12	---	---	---	---	PASS
SLCO1B3	28234	broad.mit.edu	37	12	21229461	21229461	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:21229461G>T	uc010sil.1	+	15	2071	c.2006G>T	c.(2005-2007)GGA>GTA	p.G669V	LST-3TM12_uc010sim.1_Missense_Mutation_p.G608V|LST-3TM12_uc010sin.1_Missense_Mutation_p.G561V			Q9NPD5	SO1B3_HUMAN	SubName: Full=Liver-specific organic anion transporter 3TM13; SubName: Full=Organic anion transporter LST-3c;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					AACAGCTGTGGAGCACGAGGG	0.348													41	70	---	---	---	---	PASS
GYS2	2998	broad.mit.edu	37	12	21712602	21712602	+	Silent	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:21712602G>C	uc001rfb.2	-	9	1467	c.1212C>G	c.(1210-1212)CTC>CTG	p.L404L		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	404					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						ATGCATCATAGAGTTTTTTTC	0.279													4	12	---	---	---	---	PASS
PPFIBP1	8496	broad.mit.edu	37	12	27832534	27832534	+	Silent	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:27832534C>A	uc001ric.1	+	19	2123	c.1746C>A	c.(1744-1746)TCC>TCA	p.S582S	PPFIBP1_uc010sjr.1_Silent_p.S413S|PPFIBP1_uc001rib.1_Silent_p.S576S|PPFIBP1_uc001ria.2_Silent_p.S551S|PPFIBP1_uc001rid.1_Silent_p.S429S|PPFIBP1_uc001rif.1_Silent_p.S89S	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	582					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					CTCCAGATTCCAAAAAGAAAT	0.458													6	148	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	12	31282805	31282805	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:31282805T>A	uc010sjy.1	-	24	3079	c.3079A>T	c.(3079-3081)AGT>TGT	p.S1027C						RecName: Full=Ovostatin homolog 1; Flags: Precursor;																		GTAAGAGCACTGAGCCTGTAA	0.348													7	12	---	---	---	---	PASS
MLL2	8085	broad.mit.edu	37	12	49420600	49420600	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:49420600A>C	uc001rta.3	-	48	15149	c.15149T>G	c.(15148-15150)CTG>CGG	p.L5050R		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5050					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GTCCAGGTTCAGCAGACGGGC	0.622			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			6	54	---	---	---	---	PASS
ITGA5	3678	broad.mit.edu	37	12	54794636	54794636	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:54794636G>A	uc001sga.2	-	25	2705	c.2637C>T	c.(2635-2637)GGC>GGT	p.G879G		NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	879	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						TCACCTCCAGGCCCTTTGGGT	0.572													12	19	---	---	---	---	PASS
AGAP2	116986	broad.mit.edu	37	12	58135800	58135800	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:58135800G>T	uc001spr.2	-	1	141	c.55C>A	c.(55-57)CAT>AAT	p.H19N	TSPAN31_uc001spt.2_5'Flank|TSPAN31_uc009zqb.2_5'Flank	NM_014770	NP_055585	Q99490	AGAP2_HUMAN	centaurin, gamma 1 isoform PIKE-S	Error:Variant_position_missing_in_Q99490_after_alignment					axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			central_nervous_system(3)|breast(2)	5						GCCACCTCATGTCGTCTGACT	0.587													22	46	---	---	---	---	PASS
LEMD3	23592	broad.mit.edu	37	12	65633948	65633948	+	Nonsense_Mutation	SNP	G	T	T	rs147072982	byFrequency	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:65633948G>T	uc001ssl.1	+	8	2062	c.2056G>T	c.(2056-2058)GAA>TAA	p.E686*	LEMD3_uc009zqo.1_Nonsense_Mutation_p.E685*	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	686					negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		AGCCTGCCAGGAAAACAAAGA	0.328													13	29	---	---	---	---	PASS
HELB	92797	broad.mit.edu	37	12	66700214	66700214	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:66700214A>T	uc001sti.2	+	3	725	c.697A>T	c.(697-699)ATA>TTA	p.I233L	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	233					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		TAAATGGATCATAGGGTCAGG	0.358													18	35	---	---	---	---	PASS
PPFIA2	8499	broad.mit.edu	37	12	81769626	81769626	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:81769626C>T	uc001szo.1	-	10	1241	c.1080G>A	c.(1078-1080)ATG>ATA	p.M360I	PPFIA2_uc010sue.1_Missense_Mutation_p.M260I|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	286										ovary(3)|lung(2)|pancreas(1)	6						GTTTATCATTCATGTCATGTA	0.408													8	15	---	---	---	---	PASS
RASSF9	9182	broad.mit.edu	37	12	86199616	86199616	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:86199616C>T	uc001taf.1	-	2	511	c.172G>A	c.(172-174)GAG>AAG	p.E58K		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	58	Ras-associating.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						TCATGTTCCTCAAGCAAAGCC	0.488													39	91	---	---	---	---	PASS
MYO1H	283446	broad.mit.edu	37	12	109849790	109849790	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:109849790C>T	uc010sxn.1	+	13	1454	c.1454C>T	c.(1453-1455)ACC>ATC	p.T485I		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	Error:Variant_position_missing_in_B4DNW6_after_alignment						myosin complex	motor activity				0						CACTTCGAAACGTACATACTT	0.393													6	7	---	---	---	---	PASS
DNAH10	196385	broad.mit.edu	37	12	124401007	124401007	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:124401007G>A	uc001uft.3	+	62	10397	c.10372G>A	c.(10372-10374)GCT>ACT	p.A3458T		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3458	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTTCCAGGTCGCTTCCTTTAA	0.507													44	76	---	---	---	---	PASS
ANKLE2	23141	broad.mit.edu	37	12	133327335	133327335	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr12:133327335C>G	uc001ukx.2	-	3	808	c.741G>C	c.(739-741)GAG>GAC	p.E247D	ANKLE2_uc001uky.3_Missense_Mutation_p.E185D	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	247						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		TAGCAAATTTCTCAGCGTCTT	0.393													12	33	---	---	---	---	PASS
POSTN	10631	broad.mit.edu	37	13	38154048	38154048	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr13:38154048G>T	uc001uwo.3	-	12	1728	c.1610C>A	c.(1609-1611)ACC>AAC	p.T537N	POSTN_uc010tet.1_Missense_Mutation_p.T65N|POSTN_uc001uwp.3_Missense_Mutation_p.T537N|POSTN_uc001uwr.2_Missense_Mutation_p.T537N|POSTN_uc001uwq.2_Missense_Mutation_p.T537N|POSTN_uc010teu.1_Missense_Mutation_p.T537N|POSTN_uc010tev.1_Missense_Mutation_p.T537N|POSTN_uc010tew.1_Missense_Mutation_p.T537N|POSTN_uc010tex.1_Missense_Mutation_p.T452N	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	537	FAS1 4.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		AGCATCATTGGTTGGCACAAA	0.408													14	29	---	---	---	---	PASS
TRPC4	7223	broad.mit.edu	37	13	38357173	38357173	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr13:38357173G>T	uc001uws.2	-	2	533	c.298C>A	c.(298-300)CTA>ATA	p.L100I	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Missense_Mutation_p.L100I|TRPC4_uc010tey.1_Missense_Mutation_p.L100I|TRPC4_uc010abw.2_Missense_Mutation_p.L100I|TRPC4_uc010abx.2_Missense_Mutation_p.L100I|TRPC4_uc010aby.2_Missense_Mutation_p.L100I	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	100	ANK 3.|Cytoplasmic (Potential).|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GCATGTAATAGAGCATCTCCA	0.264													11	20	---	---	---	---	PASS
PCDH8	5100	broad.mit.edu	37	13	53419706	53419706	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr13:53419706C>G	uc001vhi.2	-	2	2896	c.2693G>C	c.(2692-2694)GGA>GCA	p.G898A	PCDH8_uc001vhj.2_Missense_Mutation_p.G801A	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	898	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GAAGGAGTGTCCTTTCCACAC	0.587													11	29	---	---	---	---	PASS
DIAPH3	81624	broad.mit.edu	37	13	60590048	60590048	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr13:60590048T>A	uc001vht.2	-	7	989	c.770A>T	c.(769-771)CAG>CTG	p.Q257L	DIAPH3_uc001vhu.2_5'Flank|DIAPH3_uc001vhw.1_Missense_Mutation_p.Q246L|DIAPH3_uc010aed.1_Missense_Mutation_p.Q211L|DIAPH3_uc010aee.1_Missense_Mutation_p.Q187L|uc001vhx.2_Intron|uc001vhy.2_Intron	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	257	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		TGTACATACCTGCGTATTCAT	0.313													4	6	---	---	---	---	PASS
UCHL3	7347	broad.mit.edu	37	13	76179926	76179926	+	Missense_Mutation	SNP	C	T	T	rs139878255		TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr13:76179926C>T	uc001vjq.2	+	9	701	c.671C>T	c.(670-672)GCG>GTG	p.A224V	UCHL3_uc001vjr.2_Missense_Mutation_p.A188V	NM_006002	NP_005993	P15374	UCHL3_HUMAN	ubiquitin carboxyl-terminal esterase L3	224	Interaction with ubiquitin.				ubiquitin-dependent protein catabolic process	cytoplasm	cysteine-type peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity				0				GBM - Glioblastoma multiforme(99;0.0125)		AGATTTAATGCGATTGCTCTT	0.338													5	21	---	---	---	---	PASS
FAM155A	728215	broad.mit.edu	37	13	107822900	107822900	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr13:107822900C>T	uc001vql.2	-	3	1838	c.1322G>A	c.(1321-1323)GGA>GAA	p.G441E		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	441						integral to membrane	binding			skin(1)	1						AAAGCTCAGTCCGGCTGTGTT	0.527													15	25	---	---	---	---	PASS
MYO16	23026	broad.mit.edu	37	13	109704819	109704819	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr13:109704819G>T	uc001vqt.1	+	25	3104	c.2978G>T	c.(2977-2979)AGT>ATT	p.S993I	MYO16_uc010agk.1_Missense_Mutation_p.S1015I|MYO16_uc001vqu.1_Missense_Mutation_p.S793I|MYO16_uc010tjh.1_Missense_Mutation_p.S505I	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	993	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CTAGAACTTAGTAAGGTAGGA	0.279													20	26	---	---	---	---	PASS
CARKD	55739	broad.mit.edu	37	13	111290867	111290867	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr13:111290867G>C	uc001vrb.2	+	10	1050	c.1036G>C	c.(1036-1038)GAA>CAA	p.E346Q	CARKD_uc010tjj.1_Missense_Mutation_p.E328Q|CARKD_uc001vqz.2_RNA|CARKD_uc001vra.2_RNA|CARKD_uc010tjk.1_Missense_Mutation_p.E236Q|CARKD_uc010tjl.1_Missense_Mutation_p.E215Q|CARKD_uc001vrc.2_Nonstop_Mutation_p.*391S			Q8IW45	CARKD_HUMAN	RecName: Full=Carbohydrate kinase domain-containing protein; Flags: Precursor;	346										skin(1)	1						CAAGCTCTTTGAAACCTGAGC	0.617													3	32	---	---	---	---	PASS
ZNF828	283489	broad.mit.edu	37	13	115091162	115091162	+	Silent	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr13:115091162C>A	uc010ahb.2	+	3	2174	c.1845C>A	c.(1843-1845)TCC>TCA	p.S615S	ZNF828_uc001vuv.2_Silent_p.S615S|ZNF828_uc010tko.1_Silent_p.S615S	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	615	Mediates localization to the chromosome and the spindle and negatively regulates chromosome alignment.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		TATTTCCTTCCTCAAAGAAGC	0.373													6	140	---	---	---	---	PASS
OR4Q3	441669	broad.mit.edu	37	14	20216261	20216261	+	Silent	SNP	C	A	A	rs140842827	byFrequency	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr14:20216261C>A	uc010tkt.1	+	1	675	c.675C>A	c.(673-675)ACC>ACA	p.T225T		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCCTGATCACCCTGAGAACAC	0.493													6	100	---	---	---	---	PASS
METT11D1	64745	broad.mit.edu	37	14	21464794	21464794	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr14:21464794C>T	uc001vyn.2	+	13	1386	c.1189C>T	c.(1189-1191)CGC>TGC	p.R397C	METT11D1_uc001vym.2_Missense_Mutation_p.R397C|METT11D1_uc001vyo.2_Missense_Mutation_p.R397C|METT11D1_uc001vyp.2_Missense_Mutation_p.R239C|METT11D1_uc001vyq.2_Missense_Mutation_p.R239C|SLC39A2_uc001vyr.2_5'Flank|SLC39A2_uc001vys.2_5'Flank	NM_022734	NP_073571	Q9H7H0	MET17_HUMAN	methyltransferase 11 domain containing 1 isoform	397					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)		TAAACGGCCTCGCCATGTGCA	0.572													15	20	---	---	---	---	PASS
LRP10	26020	broad.mit.edu	37	14	23345565	23345565	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr14:23345565C>G	uc001whd.2	+	5	1961	c.1408C>G	c.(1408-1410)CGC>GGC	p.R470G	LRP10_uc001whe.2_Missense_Mutation_p.R346G	NM_014045	NP_054764	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein	470	Cytoplasmic (Potential).				endocytosis	coated pit|integral to membrane				central_nervous_system(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		CTATGCCATTCGCACCCAGGA	0.607													3	39	---	---	---	---	PASS
JPH4	84502	broad.mit.edu	37	14	24040344	24040344	+	Silent	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr14:24040344G>T	uc001wkq.2	-	6	2514	c.1596C>A	c.(1594-1596)CTC>CTA	p.L532L	JPH4_uc010tnr.1_Silent_p.L197L|JPH4_uc001wkr.2_Silent_p.L532L	NM_032452	NP_115828	Q96JJ6	JPH4_HUMAN	junctophilin 4	532	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				ovary(1)|pancreas(1)	2	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		TGCAGCCTCCGAGGAGTGGGG	0.677													6	148	---	---	---	---	PASS
AKAP6	9472	broad.mit.edu	37	14	33014470	33014470	+	Nonsense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr14:33014470C>G	uc001wrq.2	+	4	781	c.611C>G	c.(610-612)TCA>TGA	p.S204*	AKAP6_uc010aml.2_Nonsense_Mutation_p.S201*	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	204					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GTGGATGACTCAGGACAATTA	0.408													6	62	---	---	---	---	PASS
SYNE2	23224	broad.mit.edu	37	14	64450532	64450532	+	Silent	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr14:64450532A>G	uc001xgm.2	+	18	2309	c.2079A>G	c.(2077-2079)GAA>GAG	p.E693E	SYNE2_uc001xgl.2_Silent_p.E693E	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	693	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TATCTAAAGAAGAGAAAGCAA	0.284													7	19	---	---	---	---	PASS
SIPA1L1	26037	broad.mit.edu	37	14	72138262	72138262	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr14:72138262C>T	uc001xms.2	+	8	3030	c.2682C>T	c.(2680-2682)AGC>AGT	p.S894S	SIPA1L1_uc001xmt.2_Silent_p.S894S|SIPA1L1_uc001xmu.2_Silent_p.S894S|SIPA1L1_uc001xmv.2_Silent_p.S894S|SIPA1L1_uc010ttm.1_Silent_p.S369S	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	894					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		AAACAAAGAGCGTGGTCTTCA	0.463													25	52	---	---	---	---	PASS
DYNC1H1	1778	broad.mit.edu	37	14	102452390	102452390	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr14:102452390C>A	uc001yks.2	+	8	1992	c.1828C>A	c.(1828-1830)CAG>AAG	p.Q610K		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	610	Interaction with DYNC1I2 (By similarity).|Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CCAGCTGATCCAGCGCGTGAA	0.507													4	38	---	---	---	---	PASS
PPP1R13B	23368	broad.mit.edu	37	14	104251226	104251226	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr14:104251226C>G	uc001yof.1	-	3	466	c.183G>C	c.(181-183)ATG>ATC	p.M61I	PPP1R13B_uc001yog.1_5'UTR	NM_015316	NP_056131	Q96KQ4	ASPP1_HUMAN	apoptosis-stimulating protein of p53, 1	61					apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			ovary(1)	1		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				GTTCGTACATCATATGATCAA	0.388													4	51	---	---	---	---	PASS
OCA2	4948	broad.mit.edu	37	15	28230328	28230328	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr15:28230328G>C	uc001zbh.3	-	13	1356	c.1246C>G	c.(1246-1248)CGG>GGG	p.R416G	OCA2_uc010ayv.2_Missense_Mutation_p.R392G	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	416	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		CGGGAGAGCCGGTATGCCTGG	0.567									Oculocutaneous_Albinism				8	16	---	---	---	---	PASS
RYR3	6263	broad.mit.edu	37	15	34042220	34042220	+	Nonsense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr15:34042220G>A	uc001zhi.2	+	56	8310	c.8240G>A	c.(8239-8241)TGG>TAG	p.W2747*	RYR3_uc010bar.2_Nonsense_Mutation_p.W2747*	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2747	4.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CACAATATCTGGGCCAAGAAG	0.512													9	14	---	---	---	---	PASS
SPG11	80208	broad.mit.edu	37	15	44912449	44912449	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr15:44912449T>G	uc001ztx.2	-	15	2804	c.2773A>C	c.(2773-2775)ATT>CTT	p.I925L	SPG11_uc010ueh.1_Missense_Mutation_p.I925L|SPG11_uc010uei.1_Missense_Mutation_p.I925L|SPG11_uc001ztz.1_Missense_Mutation_p.I84L	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	925	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TTCTGGTTAATAACATCAACA	0.358													3	62	---	---	---	---	PASS
SHC4	399694	broad.mit.edu	37	15	49148318	49148318	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr15:49148318C>A	uc001zxb.1	-	8	1503	c.1074G>T	c.(1072-1074)GAG>GAT	p.E358D	SHC4_uc010uey.1_Missense_Mutation_p.E115D|SHC4_uc010uez.1_Missense_Mutation_p.E72D	NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	358	PID.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		TATGCACCTCCTCACTGTGAA	0.438													5	78	---	---	---	---	PASS
MNS1	55329	broad.mit.edu	37	15	56739137	56739137	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr15:56739137C>G	uc002adr.2	-	4	523	c.358G>C	c.(358-360)GAG>CAG	p.E120Q	MNS1_uc010bfo.2_5'UTR	NM_018365	NP_060835	Q8NEH6	MNS1_HUMAN	meiosis-specific nuclear structural 1	120	Potential.|Glu-rich.				meiosis					ovary(1)	1				all cancers(107;0.0196)|GBM - Glioblastoma multiforme(80;0.101)		TCTCTAAGCTCAATGCTGTTT	0.254													5	18	---	---	---	---	PASS
IGDCC4	57722	broad.mit.edu	37	15	65684253	65684253	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr15:65684253A>C	uc002aou.1	-	12	2399	c.2189T>G	c.(2188-2190)GTG>GGG	p.V730G	IGDCC4_uc002aot.1_Missense_Mutation_p.V318G	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	730	Extracellular (Potential).|Fibronectin type-III 3.					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GCCCTTCCACACTGCTGCATA	0.622													43	78	---	---	---	---	PASS
DIS3L	115752	broad.mit.edu	37	15	66621462	66621462	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr15:66621462G>A	uc010ujm.1	+	13	2371	c.2356G>A	c.(2356-2358)GGT>AGT	p.G786S	DIS3L_uc002app.2_Missense_Mutation_p.G703S|DIS3L_uc010bho.2_Missense_Mutation_p.G652S	NM_001143688	NP_001137160	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S.	786					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			ovary(2)	2						CCATCATTACGGTGAATCATA	0.433													15	25	---	---	---	---	PASS
SH2D7	646892	broad.mit.edu	37	15	78385066	78385066	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr15:78385066C>A	uc010blb.1	+	1	140	c.140C>A	c.(139-141)GCC>GAC	p.A47D		NM_001101404	NP_001094874	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	47											0						CAGAACGGTGCCCTGCCTCCC	0.607													5	10	---	---	---	---	PASS
ZNF598	90850	broad.mit.edu	37	16	2049631	2049631	+	Missense_Mutation	SNP	G	A	A	rs144186452	by1000genomes	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr16:2049631G>A	uc002cof.1	-	11	1934	c.1919C>T	c.(1918-1920)CCG>CTG	p.P640L	ZNF598_uc002coe.1_Missense_Mutation_p.P4L	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	640	Pro-rich.					intracellular	zinc ion binding			lung(1)|breast(1)	2						AGCAGGGGCCGGGCCCTCCAT	0.711													6	8	---	---	---	---	PASS
SRRM2	23524	broad.mit.edu	37	16	2812505	2812505	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr16:2812505G>T	uc002crk.2	+	11	2525	c.1976G>T	c.(1975-1977)CGC>CTC	p.R659L	SRRM2_uc002crj.1_Missense_Mutation_p.R563L|SRRM2_uc002crl.1_Missense_Mutation_p.R659L|SRRM2_uc010bsu.1_Missense_Mutation_p.R563L	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	659	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GGCCGCTCACGCTCCAGAACC	0.622													24	62	---	---	---	---	PASS
SRRM2	23524	broad.mit.edu	37	16	2813279	2813279	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr16:2813279C>T	uc002crk.2	+	11	3299	c.2750C>T	c.(2749-2751)CCC>CTC	p.P917L	SRRM2_uc002crj.1_Missense_Mutation_p.P821L|SRRM2_uc002crl.1_Missense_Mutation_p.P917L|SRRM2_uc010bsu.1_Missense_Mutation_p.P821L	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	917	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TCTCCACAACCCAAAGTGAAG	0.512													21	44	---	---	---	---	PASS
CLDN6	9074	broad.mit.edu	37	16	3066004	3066004	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr16:3066004G>T	uc002csu.3	-	2	79	c.19C>A	c.(19-21)CAG>AAG	p.Q7K		NM_021195	NP_067018	P56747	CLD6_HUMAN	claudin 6	7	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						CCCAGGATCTGCATTCCGGCA	0.602													7	17	---	---	---	---	PASS
MKL2	57496	broad.mit.edu	37	16	14340860	14340860	+	Silent	SNP	C	T	T	rs148779363	byFrequency	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr16:14340860C>T	uc010uza.1	+	12	1898	c.1743C>T	c.(1741-1743)ATC>ATT	p.I581I	MKL2_uc002dcg.2_Silent_p.I581I|MKL2_uc002dcj.2_5'Flank	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	570	Required for interaction with itself and with MKL1.|Potential.				cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						AGAAGCAAATCGAAGAGCTGA	0.507													5	49	---	---	---	---	PASS
ERN2	10595	broad.mit.edu	37	16	23712343	23712343	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr16:23712343G>T	uc002dma.3	-	12	1609	c.1440C>A	c.(1438-1440)GAC>GAA	p.D480E	ERN2_uc010bxp.2_Intron|ERN2_uc010bxq.1_Missense_Mutation_p.D288E	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	432	Helical; (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CTGCCAGCAGGTCTTGGGGTC	0.572													24	37	---	---	---	---	PASS
PRKCB	5579	broad.mit.edu	37	16	24196462	24196462	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr16:24196462G>T	uc002dmd.2	+	14	1761	c.1564G>T	c.(1564-1566)GTG>TTG	p.V522L	PRKCB_uc002dme.2_Missense_Mutation_p.V522L	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	522	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	TGGGAAGTCCGTGGATTGGTG	0.458													28	34	---	---	---	---	PASS
ABCC11	85320	broad.mit.edu	37	16	48234333	48234333	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr16:48234333G>A	uc002eff.1	-	14	2286	c.1936C>T	c.(1936-1938)CGC>TGC	p.R646C	ABCC11_uc002efg.1_Missense_Mutation_p.R646C|ABCC11_uc002efh.1_Missense_Mutation_p.R646C|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	646	ABC transporter 1.|Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				TAGACGGCGCGGGCCAGGCTG	0.582									Cerumen_Type				20	24	---	---	---	---	PASS
CES7	221223	broad.mit.edu	37	16	55883659	55883659	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr16:55883659C>T	uc002eip.2	-	11	1449	c.1300G>A	c.(1300-1302)GAG>AAG	p.E434K	CES7_uc002eio.2_Intron|CES7_uc002eiq.2_Missense_Mutation_p.E195K|CES7_uc002eir.2_Missense_Mutation_p.E328K	NM_001143685	NP_001137157	Q6NT32	EST5A_HUMAN	carboxylesterase 7 isoform 1	434						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.229)|Epithelial(162;0.231)		TGCCGAAACTCATAGAAGTAG	0.567													6	112	---	---	---	---	PASS
GAN	8139	broad.mit.edu	37	16	81397433	81397433	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr16:81397433G>T	uc002fgo.2	+	7	1269	c.1121G>T	c.(1120-1122)GGG>GTG	p.G374V		NM_022041	NP_071324	Q9H2C0	GAN_HUMAN	gigaxonin	374	Kelch 2.				cell death	cytoplasm|neurofilament	protein binding			ovary(2)	2		Colorectal(91;0.153)				GAGATAGATGGGATGCTGTAC	0.398													6	91	---	---	---	---	PASS
JPH3	57338	broad.mit.edu	37	16	87678227	87678227	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr16:87678227G>A	uc002fkd.2	+	2	1000	c.746G>A	c.(745-747)GGC>GAC	p.G249D	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	249	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		AGCGAGGCGGGCATGAGCACC	0.672													4	71	---	---	---	---	PASS
SPIRE2	84501	broad.mit.edu	37	16	89936621	89936621	+	Missense_Mutation	SNP	C	T	T	rs144349271		TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr16:89936621C>T	uc002foz.1	+	15	2138	c.2086C>T	c.(2086-2088)CGC>TGC	p.R696C	SPIRE2_uc010ciw.1_Missense_Mutation_p.R648C|SPIRE2_uc002fpa.1_Missense_Mutation_p.R648C|SPIRE2_uc010cix.1_Missense_Mutation_p.R563C	NM_032451	NP_115827	Q8WWL2	SPIR2_HUMAN	spire homolog 2	696					transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)	1		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		TACGCCACGACGCAGTCGCCA	0.607													8	2	---	---	---	---	PASS
VPS53	55275	broad.mit.edu	37	17	534816	534816	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr17:534816C>T	uc002frn.2	-	8	808	c.661G>A	c.(661-663)GAA>AAA	p.E221K	VPS53_uc002frk.2_5'UTR|VPS53_uc010cjo.1_Missense_Mutation_p.E221K|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Missense_Mutation_p.E192K|VPS53_uc002fro.2_Missense_Mutation_p.E23K|VPS53_uc010cjp.1_Intron	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	221					protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		GGAAACGCTTCTTCAAAATCT	0.498													7	44	---	---	---	---	PASS
CTNS	1497	broad.mit.edu	37	17	3563244	3563244	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr17:3563244G>A	uc002fwb.2	+	11	1538	c.945G>A	c.(943-945)CAG>CAA	p.Q315Q	CTNS_uc002fwa.2_Silent_p.Q315Q|CTNS_uc010ckj.2_Silent_p.Q315Q|CTNS_uc010vrv.1_Silent_p.Q168Q|CTNS_uc010vrw.1_Silent_p.Q207Q	NM_004937	NP_004928	O60931	CTNS_HUMAN	cystinosin isoform 2	315	Helical; (Potential).|PQ-loop 2.				ATP metabolic process|brain development|cognition|glutathione metabolic process	integral to membrane|late endosome|lysosomal membrane	L-cystine transmembrane transporter activity				0				COAD - Colon adenocarcinoma(5;0.0829)	L-Cystine(DB00138)	GCCTCCTGCAGATGTTCCTCC	0.627													6	9	---	---	---	---	PASS
TP53	7157	broad.mit.edu	37	17	7577120	7577120	+	Missense_Mutation	SNP	C	A	A	rs28934576	by1000genomes	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr17:7577120C>A	uc002gim.2	-	8	1012	c.818G>T	c.(817-819)CGT>CTT	p.R273L	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141L|TP53_uc010cng.1_Missense_Mutation_p.R141L|TP53_uc002gii.1_Missense_Mutation_p.R141L|TP53_uc010cnh.1_Missense_Mutation_p.R273L|TP53_uc010cni.1_Missense_Mutation_p.R273L|TP53_uc002gij.2_Missense_Mutation_p.R273L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	7	---	---	---	---	PASS
CCL3	6348	broad.mit.edu	37	17	34416024	34416024	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr17:34416024A>T	uc002hkv.2	-	3	375	c.273T>A	c.(271-273)AGT>AGA	p.S91R		NM_002983	NP_002974	P10147	CCL3_HUMAN	chemokine (C-C motif) ligand 3	91					cell-cell signaling|cellular calcium ion homeostasis|cellular component movement|cytoskeleton organization|exocytosis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|regulation of viral genome replication	extracellular space|soluble fraction	chemoattractant activity|chemokine activity|signal transducer activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCCCTCAGGCACTCAGCTCCA	0.627													21	23	---	---	---	---	PASS
SLC25A39	51629	broad.mit.edu	37	17	42398095	42398095	+	Silent	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr17:42398095C>G	uc002ign.2	-	9	850	c.696G>C	c.(694-696)CTG>CTC	p.L232L	SLC25A39_uc002igm.2_Silent_p.L224L|SLC25A39_uc002igo.2_Silent_p.L224L|SLC25A39_uc010wiw.1_Silent_p.L209L|SLC25A39_uc010czu.2_Silent_p.L100L|SLC25A39_uc010wix.1_3'UTR|SLC25A39_uc010wiy.1_3'UTR	NM_001143780	NP_001137252	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39 isoform a	232	Helical; Name=4; (Potential).|Solcar 2.				heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				upper_aerodigestive_tract(1)	1		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TGAACCAGTACAGGGCTTGGG	0.582													35	13	---	---	---	---	PASS
GRN	2896	broad.mit.edu	37	17	42429158	42429158	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr17:42429158C>A	uc002igp.1	+	10	1393	c.1174C>A	c.(1174-1176)CCA>ACA	p.P392T	GRN_uc002igr.1_Missense_Mutation_p.P186T	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	392					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		CTGTCCAATCCCAGAGGTATA	0.582													4	22	---	---	---	---	PASS
TBX21	30009	broad.mit.edu	37	17	45822322	45822322	+	Nonsense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr17:45822322C>T	uc002ilv.1	+	6	1409	c.1198C>T	c.(1198-1200)CGA>TGA	p.R400*		NM_013351	NP_037483	Q9UL17	TBX21_HUMAN	T-box 21	400					lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						GGCTGAGTTTCGAGCAGTCAG	0.652													10	24	---	---	---	---	PASS
SFRS1	6426	broad.mit.edu	37	17	56083716	56083716	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr17:56083716C>G	uc002ivi.2	-	2	576	c.367G>C	c.(367-369)GTG>CTG	p.V123L	SFRS1_uc002ivj.2_Missense_Mutation_p.V123L	NM_006924	NP_008855	Q07955	SRSF1_HUMAN	splicing factor, arginine/serine-rich 1 isoform	123	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA 5'-splice site recognition|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytoplasm|nuclear speck	nucleotide binding|RNA binding				0		Colorectal(1115;0.0691)		LUAD - Lung adenocarcinoma(1115;0.247)		GAGACAACCACTCTGTTTTCA	0.552													38	12	---	---	---	---	PASS
ACOX1	51	broad.mit.edu	37	17	73945424	73945424	+	Silent	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr17:73945424C>A	uc002jqf.2	-	12	1892	c.1602G>T	c.(1600-1602)GTG>GTT	p.V534V	ACOX1_uc010wsq.1_Silent_p.V496V|ACOX1_uc002jqe.2_Silent_p.V534V|ACOX1_uc010wsr.1_Silent_p.V466V	NM_007292	NP_009223	Q15067	ACOX1_HUMAN	acyl-Coenzyme A oxidase 1 isoform b	534				VV -> GL (in Ref. 1; AAA19113 and 2; AAA18595).	fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			ovary(1)	1						GCTTAACTACCACATAGTGGC	0.358													5	110	---	---	---	---	PASS
RNF213	57674	broad.mit.edu	37	17	78319717	78319717	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr17:78319717C>T	uc002jyh.1	+	4	2024	c.1801C>T	c.(1801-1803)CGG>TGG	p.R601W		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CAATCCATACCGGAAGCACTC	0.527													30	11	---	---	---	---	PASS
NDUFV2	4729	broad.mit.edu	37	18	9122569	9122569	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr18:9122569C>T	uc002knu.2	+	5	426	c.359C>T	c.(358-360)ACA>ATA	p.T120I		NM_021074	NP_066552	P19404	NDUV2_HUMAN	NADH dehydrogenase ubiquinone flavoprotein 2	120					cardiac muscle tissue development|mitochondrial electron transport, NADH to ubiquinone|nervous system development|transport	mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			ovary(1)	1					NADH(DB00157)	ACTTTTTATACAATGTATAAT	0.363													9	63	---	---	---	---	PASS
ZNF521	25925	broad.mit.edu	37	18	22805745	22805745	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr18:22805745G>T	uc002kvk.2	-	4	2384	c.2137C>A	c.(2137-2139)CTG>ATG	p.L713M	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.L713M|ZNF521_uc002kvl.2_Missense_Mutation_p.L493M	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	713	C2H2-type 16.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					ATGTCCAGCAGGTGTTTCTGA	0.453			T	PAX5	ALL								5	75	---	---	---	---	PASS
CDH7	1005	broad.mit.edu	37	18	63477173	63477173	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr18:63477173C>A	uc002ljz.2	+	3	769	c.444C>A	c.(442-444)GAC>GAA	p.D148E	CDH7_uc002lka.2_Missense_Mutation_p.D148E|CDH7_uc002lkb.2_Missense_Mutation_p.D148E	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	148	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				ATATCAACGACAATGAACCCA	0.507													4	71	---	---	---	---	PASS
CTDP1	9150	broad.mit.edu	37	18	77477810	77477810	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr18:77477810G>T	uc002lnh.1	+	10	2358	c.2211G>T	c.(2209-2211)AGG>AGT	p.R737S	CTDP1_uc002lni.1_Missense_Mutation_p.R737S|CTDP1_uc010drd.1_Missense_Mutation_p.R737S	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	737					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		CCTCCGACAGGGAGAACAGCC	0.677													19	4	---	---	---	---	PASS
CCDC94	55702	broad.mit.edu	37	19	4254382	4254382	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:4254382G>C	uc002lzv.3	+	4	334	c.301G>C	c.(301-303)GAG>CAG	p.E101Q		NM_018074	NP_060544	Q9BW85	CCD94_HUMAN	coiled-coil domain containing 94	101											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0348)|STAD - Stomach adenocarcinoma(1328;0.183)		CTACACCATGGAGCATGGAGC	0.403													22	36	---	---	---	---	PASS
TMEM146	257062	broad.mit.edu	37	19	5751819	5751819	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:5751819C>T	uc002mda.2	+	12	1210	c.1149C>T	c.(1147-1149)CAC>CAT	p.H383H	TMEM146_uc010duj.1_Silent_p.H41H	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	383	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						CTGAACTCCACGTTGGAAAGT	0.378													14	28	---	---	---	---	PASS
PNPLA6	10908	broad.mit.edu	37	19	7625941	7625941	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:7625941G>C	uc010xjq.1	+	32	4083	c.3888G>C	c.(3886-3888)GAG>GAC	p.E1296D	PNPLA6_uc002mgq.1_Missense_Mutation_p.E1248D|PNPLA6_uc010xjp.1_Missense_Mutation_p.E1221D|PNPLA6_uc002mgr.1_Missense_Mutation_p.E1248D|PNPLA6_uc002mgs.2_Missense_Mutation_p.E1286D|PNPLA6_uc002mgt.1_RNA	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	1287	Cytoplasmic (Potential).			E -> G (in Ref. 5; CAB43674).	cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						ACTTGGCAGAGATTGTGTCCC	0.642													4	8	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9072086	9072086	+	Silent	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:9072086A>G	uc002mkp.2	-	3	15564	c.15360T>C	c.(15358-15360)TCT>TCC	p.S5120S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5122	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGTGTTTATAGAAGGAAAAA	0.443													44	49	---	---	---	---	PASS
ZNF440	126070	broad.mit.edu	37	19	11943153	11943153	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:11943153A>G	uc002msp.1	+	4	1318	c.1162A>G	c.(1162-1164)AGG>GGG	p.R388G		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	388	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATATCATGAAAGGACTCACAC	0.443													30	38	---	---	---	---	PASS
ZNF536	9745	broad.mit.edu	37	19	30934940	30934940	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:30934940C>T	uc002nsu.1	+	2	609	c.471C>T	c.(469-471)CCC>CCT	p.P157P	ZNF536_uc010edd.1_Silent_p.P157P	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	157					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCGAGAAGCCCTTCAAGTGCC	0.652													16	32	---	---	---	---	PASS
ZNF181	339318	broad.mit.edu	37	19	35232191	35232191	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:35232191T>C	uc002nvu.3	+	4	1368	c.905T>C	c.(904-906)TTT>TCT	p.F302S	ZNF181_uc010xsa.1_Missense_Mutation_p.F301S|ZNF181_uc010xsb.1_Missense_Mutation_p.F301S|ZNF181_uc010xsc.1_Missense_Mutation_p.F237S	NM_001029997	NP_001025168	Q2M3W8	ZN181_HUMAN	zinc finger protein 181 isoform 1	302	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			GGGAAGGCCTTTAGCCATGTC	0.428													7	62	---	---	---	---	PASS
ZNF571	51276	broad.mit.edu	37	19	38055702	38055702	+	Nonsense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:38055702G>C	uc002ogt.2	-	4	1729	c.1628C>G	c.(1627-1629)TCA>TGA	p.S543*	uc002ogm.2_Intron|uc002ogn.2_Intron|ZNF540_uc002ogo.2_Intron|ZNF540_uc002ogp.2_Intron|ZNF540_uc002ogq.2_Intron|ZNF571_uc002ogr.1_Intron|uc002ogs.1_5'Flank|ZNF571_uc010efp.2_Nonsense_Mutation_p.S543*	NM_016536	NP_057620	Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	543	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGTAAGGTGTGAGCCACGAAT	0.423													4	29	---	---	---	---	PASS
PPP1R14A	94274	broad.mit.edu	37	19	38742961	38742961	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:38742961A>C	uc002ohq.2	-	3	493	c.300T>G	c.(298-300)TGT>TGG	p.C100W	PPP1R14A_uc010efv.2_Missense_Mutation_p.C73W	NM_033256	NP_150281	Q96A00	PP14A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	100	Inhibitory.				regulation of phosphorylation	cytoplasm	protein binding|protein phosphatase inhibitor activity				0	all_cancers(60;9.57e-07)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CAGGTTTCCCACATGACTTCA	0.522													11	11	---	---	---	---	PASS
GPR77	27202	broad.mit.edu	37	19	47844500	47844500	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:47844500G>A	uc010ela.1	+	2	662	c.444G>A	c.(442-444)GCG>GCA	p.A148A	GPR77_uc002pgk.1_Silent_p.A148A	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	148	Cytoplasmic (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		TTCAGCGGGCGTGCGGGGTGC	0.677													50	30	---	---	---	---	PASS
GPR77	27202	broad.mit.edu	37	19	47844501	47844501	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:47844501T>A	uc010ela.1	+	2	663	c.445T>A	c.(445-447)TGC>AGC	p.C149S	GPR77_uc002pgk.1_Missense_Mutation_p.C149S	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	149	Cytoplasmic (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		TCAGCGGGCGTGCGGGGTGCA	0.682													48	30	---	---	---	---	PASS
FPR2	2358	broad.mit.edu	37	19	52272195	52272195	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:52272195G>C	uc002pxr.2	+	2	329	c.284G>C	c.(283-285)TGG>TCG	p.W95S	FPR2_uc002pxs.3_Missense_Mutation_p.W95S|FPR2_uc010epf.2_Missense_Mutation_p.W95S	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	95	Extracellular (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						CCTTTTGGCTGGTTCCTGTGT	0.473													57	44	---	---	---	---	PASS
ZNF28	7576	broad.mit.edu	37	19	53304795	53304795	+	Nonsense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:53304795C>T	uc002qad.2	-	4	423	c.303G>A	c.(301-303)TGG>TGA	p.W101*	ZNF28_uc002qac.2_Nonsense_Mutation_p.W48*|ZNF28_uc010eqe.2_Nonsense_Mutation_p.W47*	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		CATCTTCTTTCCACTGAAACT	0.428													57	132	---	---	---	---	PASS
LILRB5	10990	broad.mit.edu	37	19	54758611	54758611	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:54758611C>G	uc002qex.2	-	6	1353	c.1242G>C	c.(1240-1242)GAG>GAC	p.E414D	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.E405D|LILRB5_uc002qey.2_Missense_Mutation_p.E414D|LILRB5_uc002qez.2_Missense_Mutation_p.E314D|LILRB5_uc002qfa.1_Missense_Mutation_p.E304D|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	414	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AGACCACGAGCTCCTGGGGGT	0.632													32	22	---	---	---	---	PASS
LILRB2	10288	broad.mit.edu	37	19	54782923	54782923	+	Silent	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:54782923A>G	uc002qfb.2	-	6	965	c.699T>C	c.(697-699)CCT>CCC	p.P233P	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Silent_p.P233P|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Silent_p.P233P|LILRB2_uc010yet.1_Silent_p.P117P|LILRB2_uc010yeu.1_Intron	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	233	Extracellular (Potential).|Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGCCACGACAGGACCCGGCT	0.577													36	47	---	---	---	---	PASS
LILRA1	11024	broad.mit.edu	37	19	55106308	55106308	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:55106308C>T	uc002qgh.1	+	4	431	c.249C>T	c.(247-249)TTC>TTT	p.F83F	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Silent_p.F83F	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	83	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		AGGGCCAGTTCCCCATCCCAT	0.567													7	129	---	---	---	---	PASS
LILRB1	10859	broad.mit.edu	37	19	55143129	55143129	+	Silent	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:55143129C>T	uc002qgj.2	+	5	589	c.249C>T	c.(247-249)TTC>TTT	p.F83F	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Silent_p.F83F|LILRB1_uc002qgk.2_Silent_p.F83F|LILRB1_uc002qgm.2_Silent_p.F83F|LILRB1_uc010erq.2_Silent_p.F83F|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	83	Ig-like C2-type 1.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		AGGGCCAGTTCCCCATCCCAT	0.567										HNSCC(37;0.09)			59	70	---	---	---	---	PASS
KIR2DS4	3809	broad.mit.edu	37	19	55351040	55351040	+	Missense_Mutation	SNP	G	A	A	rs3189418		TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:55351040G>A	uc002qhm.1	+	5	596	c.550G>A	c.(550-552)GAC>AAC	p.D184N	KIR2DS4_uc010yfj.1_Silent_p.P169P|KIR2DS4_uc010yfk.1_RNA|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_Silent_p.P176P|KIR2DS4_uc002qhn.1_Intron	NM_012314	NP_036446	P43632	KI2S4_HUMAN	killer cell immunoglobulin-like receptor, two	184	Extracellular (Potential).|Ig-like C2-type 2.					integral to plasma membrane	receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		ATTCCAGGCCGACTTTCCTCT	0.587													53	46	---	---	---	---	PASS
NLRP7	199713	broad.mit.edu	37	19	55451776	55451776	+	Silent	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:55451776G>T	uc002qih.3	-	4	487	c.411C>A	c.(409-411)ACC>ACA	p.T137T	NLRP7_uc002qig.3_Silent_p.T137T|NLRP7_uc002qii.3_Silent_p.T137T|NLRP7_uc010esk.2_Silent_p.T137T|NLRP7_uc010esl.2_Silent_p.T165T	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	137							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		CTTGCCAAAAGGTGTTCTTCC	0.453													218	208	---	---	---	---	PASS
TNNT1	7138	broad.mit.edu	37	19	55652325	55652325	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:55652325G>A	uc002qjb.3	-	9	402	c.313C>T	c.(313-315)CGG>TGG	p.R105W	TNNT1_uc002qiz.3_Missense_Mutation_p.R35W|TNNT1_uc002qja.3_Missense_Mutation_p.R35W|TNNT1_uc002qjc.3_Missense_Mutation_p.R105W|TNNT1_uc002qje.3_Missense_Mutation_p.R94W|TNNT1_uc002qjd.3_Missense_Mutation_p.R94W|TNNT1_uc002qjf.2_Missense_Mutation_p.R101W	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	105					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		GACCGGCGCCGCTCCTGGGAA	0.607											OREG0025677	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	20	---	---	---	---	PASS
NLRP5	126206	broad.mit.edu	37	19	56515098	56515098	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:56515098A>T	uc002qmj.2	+	2	79	c.79A>T	c.(79-81)ACA>TCA	p.T27S	NLRP5_uc002qmi.2_Missense_Mutation_p.T27S	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	27						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CACTCTTTCCACAGGTCCTAC	0.418													48	34	---	---	---	---	PASS
SIRPG	55423	broad.mit.edu	37	20	1616857	1616857	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:1616857G>C	uc002wfm.1	-	3	790	c.725C>G	c.(724-726)GCC>GGC	p.A242G	SIRPG_uc002wfn.1_Missense_Mutation_p.A242G|SIRPG_uc002wfo.1_Intron|uc002wfp.1_Intron	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	242	Extracellular (Potential).|Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						AGACAAGTTGGCAGTCCCACG	0.637													20	32	---	---	---	---	PASS
SIRPA	140885	broad.mit.edu	37	20	1915374	1915374	+	Nonsense_Mutation	SNP	G	T	T	rs141454528		TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:1915374G>T	uc002wfq.2	+	8	1600	c.1240G>T	c.(1240-1242)GAG>TAG	p.E414*	SIRPA_uc010zps.1_Nonsense_Mutation_p.E394*|SIRPA_uc002wfr.2_Nonsense_Mutation_p.E414*|SIRPA_uc002wfs.2_Nonsense_Mutation_p.E414*|SIRPA_uc002wft.2_Nonsense_Mutation_p.E414*	NM_001040022	NP_001035111	P78324	SHPS1_HUMAN	signal-regulatory protein alpha precursor	414	Cytoplasmic (Potential).				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			ovary(1)	1				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		GCATGAGCCCGAGAAGAATGC	0.338													51	59	---	---	---	---	PASS
SLC4A11	83959	broad.mit.edu	37	20	3218266	3218266	+	Silent	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:3218266A>G	uc002wig.2	-	1	108	c.60T>C	c.(58-60)CAT>CAC	p.H20H	SLC4A11_uc010zqe.1_Intron|SLC4A11_uc002wih.2_Intron|SLC4A11_uc010zqf.1_Intron	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	20	Cytoplasmic (Potential).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						CACCAGCCCCATGGACCAAGC	0.592													8	87	---	---	---	---	PASS
HSPA12B	116835	broad.mit.edu	37	20	3725561	3725561	+	Silent	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:3725561C>A	uc002wjd.2	+	5	382	c.279C>A	c.(277-279)GGC>GGA	p.G93G	HSPA12B_uc010zqi.1_Silent_p.G93G|HSPA12B_uc002wje.2_Silent_p.G6G|HSPA12B_uc010zqj.1_5'UTR	NM_052970	NP_443202	Q96MM6	HS12B_HUMAN	heat shock 70kD protein 12B	93							ATP binding				0						AATGGGAGGGCGGAGACCCGG	0.532													25	37	---	---	---	---	PASS
PRNP	5621	broad.mit.edu	37	20	4680514	4680514	+	Silent	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:4680514C>A	uc002wku.2	+	2	1011	c.648C>A	c.(646-648)ACC>ACA	p.T216T	PRNP_uc002wkv.2_Silent_p.T216T|PRNP_uc002wkw.2_Silent_p.T216T|PRNP_uc002wkx.2_Silent_p.T216T|PRNP_uc002wkt.1_Silent_p.T186T|PRNP_uc002wky.2_Silent_p.T216T|PRNP_uc010gbe.1_Silent_p.T216T	NM_001080122	NP_001073591	P04156	PRIO_HUMAN	prion protein preproprotein	216	Interaction with GRB2, ERI3 and SYN1 (By similarity).				axon guidance|cell cycle arrest|cellular copper ion homeostasis|metabolic process|negative regulation of activated T cell proliferation|negative regulation of calcineurin-NFAT signaling pathway|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-2 production|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell receptor signaling pathway|protein homooligomerization|response to oxidative stress	anchored to membrane|endoplasmic reticulum|extrinsic to membrane|Golgi apparatus|membrane raft|nucleus|plasma membrane	copper ion binding|identical protein binding|microtubule binding			central_nervous_system(1)	1					Tetracycline(DB00759)	TGTGTATCACCCAGTACGAGA	0.532													5	66	---	---	---	---	PASS
RALGAPA2	57186	broad.mit.edu	37	20	20493389	20493389	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:20493389G>C	uc002wrz.2	-	32	4767	c.4624C>G	c.(4624-4626)CTA>GTA	p.L1542V	RALGAPA2_uc010gcx.2_Missense_Mutation_p.L1246V|RALGAPA2_uc010zsg.1_Missense_Mutation_p.L990V|RALGAPA2_uc002wsa.1_Missense_Mutation_p.L314V	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1542					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						GGTTCATTTAGATTTAGCTGT	0.413													32	120	---	---	---	---	PASS
TMEM90B	79953	broad.mit.edu	37	20	24523840	24523840	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:24523840G>C	uc002wtw.1	+	2	740	c.107G>C	c.(106-108)AGA>ACA	p.R36T		NM_024893	NP_079169	Q9H7V2	SYNG1_HUMAN	transmembrane protein 90B	36	Cytoplasmic (Potential).				response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane					0						GCCGAGAGCAGAGATGGTCTG	0.562													5	90	---	---	---	---	PASS
ZNF337	26152	broad.mit.edu	37	20	25656728	25656728	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:25656728G>A	uc002wva.2	-	4	1718	c.1196C>T	c.(1195-1197)TCA>TTA	p.S399L	uc002wuz.2_RNA|ZNF337_uc010ztg.1_Missense_Mutation_p.S367L|ZNF337_uc002wvb.2_Missense_Mutation_p.S399L|ZNF337_uc002wvc.2_Missense_Mutation_p.S399L	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	399					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTCTCCCCTGAGTGTGTTCT	0.498													24	75	---	---	---	---	PASS
PLUNC	51297	broad.mit.edu	37	20	31825574	31825574	+	Silent	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:31825574C>A	uc002wyv.2	+	2	127	c.57C>A	c.(55-57)GCC>GCA	p.A19A	PLUNC_uc002wyt.3_Silent_p.A19A|PLUNC_uc002wyu.3_Silent_p.A19A	NM_130852	NP_570913	Q9NP55	PLUNC_HUMAN	palate, lung and nasal epithelium associated	19					innate immune response	extracellular region	lipid binding				0						AGACCATGGCCCAGTTTGGAG	0.552													15	32	---	---	---	---	PASS
PLUNC	51297	broad.mit.edu	37	20	31825575	31825575	+	Nonsense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:31825575C>T	uc002wyv.2	+	2	128	c.58C>T	c.(58-60)CAG>TAG	p.Q20*	PLUNC_uc002wyt.3_Nonsense_Mutation_p.Q20*|PLUNC_uc002wyu.3_Nonsense_Mutation_p.Q20*	NM_130852	NP_570913	Q9NP55	PLUNC_HUMAN	palate, lung and nasal epithelium associated	20					innate immune response	extracellular region	lipid binding				0						GACCATGGCCCAGTTTGGAGG	0.547													17	32	---	---	---	---	PASS
CHMP4B	128866	broad.mit.edu	37	20	32439921	32439921	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:32439921G>T	uc002xaa.2	+	4	678	c.522G>T	c.(520-522)GAG>GAT	p.E174D		NM_176812	NP_789782	Q9H444	CHM4B_HUMAN	chromatin modifying protein 4B	174	Potential.				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			ovary(1)|central_nervous_system(1)	2						TAGAACAGGAGGAACTAGACA	0.507													6	121	---	---	---	---	PASS
MYH7B	57644	broad.mit.edu	37	20	33575001	33575001	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:33575001A>G	uc002xbi.1	+	14	1276	c.1184A>G	c.(1183-1185)TAT>TGT	p.Y395C		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	353	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TGTGCCTGCTATAAGATCGTG	0.607													36	68	---	---	---	---	PASS
FAM83D	81610	broad.mit.edu	37	20	37580566	37580566	+	Silent	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:37580566T>C	uc002xjg.2	+	4	1292	c.1251T>C	c.(1249-1251)ATT>ATC	p.I417I		NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	387					cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)				GAAAGGCCATTGACGCTGCCA	0.567													15	22	---	---	---	---	PASS
MATN4	8785	broad.mit.edu	37	20	43932922	43932922	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:43932922C>A	uc002xnn.2	-	3	776	c.589G>T	c.(589-591)GAG>TAG	p.E197*	MATN4_uc002xno.2_Nonsense_Mutation_p.E197*|MATN4_uc002xnp.2_Nonsense_Mutation_p.E197*|MATN4_uc010zwr.1_Nonsense_Mutation_p.E145*|MATN4_uc002xnr.1_Nonsense_Mutation_p.E197*|RBPJL_uc002xns.2_5'Flank|RBPJL_uc002xnt.2_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	197	VWFA 1.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				TCGAAGGACTCTACGAGGAAG	0.627													5	80	---	---	---	---	PASS
SLC35C2	51006	broad.mit.edu	37	20	44986276	44986276	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:44986276C>A	uc002xro.2	-	3	798	c.257G>T	c.(256-258)AGA>ATA	p.R86I	SLC35C2_uc002xrp.2_Missense_Mutation_p.R86I|SLC35C2_uc002xrq.2_Missense_Mutation_p.R86I|SLC35C2_uc002xrr.2_Missense_Mutation_p.R86I|SLC35C2_uc010zxn.1_5'UTR|SLC35C2_uc010zxo.1_5'UTR|SLC35C2_uc010zxp.1_Missense_Mutation_p.R115I	NM_173179	NP_775271	Q9NQQ7	S35C2_HUMAN	solute carrier family 35, member C2 isoform a	86					transport	integral to membrane				ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GGGAGCCACTCTTCTGAGGTA	0.627													27	57	---	---	---	---	PASS
NCOA3	8202	broad.mit.edu	37	20	46254215	46254215	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:46254215T>G	uc002xtk.2	+	5	552	c.347T>G	c.(346-348)CTT>CGT	p.L116R	NCOA3_uc010ght.1_Missense_Mutation_p.L116R|NCOA3_uc002xtl.2_Missense_Mutation_p.L116R|NCOA3_uc002xtm.2_Missense_Mutation_p.L116R|NCOA3_uc002xtn.2_Missense_Mutation_p.L116R|NCOA3_uc010zyc.1_5'Flank	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	116	PAS.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						TTAGGACCGCTTTTACTTCAG	0.348													5	52	---	---	---	---	PASS
TSHZ2	128553	broad.mit.edu	37	20	51872343	51872343	+	Silent	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:51872343T>C	uc002xwo.2	+	2	3302	c.2346T>C	c.(2344-2346)TCT>TCC	p.S782S		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	782					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			AAGCACAATCTTGTATGTCCC	0.572													42	88	---	---	---	---	PASS
SPO11	23626	broad.mit.edu	37	20	55906898	55906898	+	Silent	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:55906898T>C	uc002xye.2	+	2	234	c.141T>C	c.(139-141)GTT>GTC	p.V47V	SPO11_uc002xyf.2_Intron	NM_012444	NP_036576	Q9Y5K1	SPO11_HUMAN	meiotic recombination protein SPO11 isoform a	47					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			breast(2)|skin(1)	3	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)			GTTCTGAGGTTCTTGCATCTA	0.328								Editing_and_processing_nucleases					7	152	---	---	---	---	PASS
ZNF831	128611	broad.mit.edu	37	20	57768671	57768671	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:57768671C>T	uc002yan.2	+	1	2597	c.2597C>T	c.(2596-2598)CCA>CTA	p.P866L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	866						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GGGGAGGTGCCAGGGGGCTCA	0.652													20	22	---	---	---	---	PASS
CDH26	60437	broad.mit.edu	37	20	58581786	58581786	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:58581786A>G	uc002ybe.2	+	17	2539	c.2239A>G	c.(2239-2241)ATG>GTG	p.M747V	CDH26_uc002ybf.1_Missense_Mutation_p.M286V|CDH26_uc010zzy.1_RNA|CDH26_uc002ybg.2_Missense_Mutation_p.M238V|CDH26_uc002ybh.2_Missense_Mutation_p.M80V|CDH26_uc002ybi.2_Missense_Mutation_p.M39V	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	706	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			AGATGCCACAATGCACAGACA	0.557													22	60	---	---	---	---	PASS
CDH4	1002	broad.mit.edu	37	20	60504842	60504842	+	Silent	SNP	G	A	A	rs151300553		TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:60504842G>A	uc002ybn.1	+	13	2195	c.2181G>A	c.(2179-2181)GCG>GCA	p.A727A	CDH4_uc002ybp.1_Silent_p.A653A	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	727	Extracellular (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CAGTGGCAGCGGCTGGTCTGG	0.607													12	34	---	---	---	---	PASS
LAMA5	3911	broad.mit.edu	37	20	60885614	60885614	+	Silent	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:60885614G>A	uc002ycq.2	-	76	10528	c.10461C>T	c.(10459-10461)TTC>TTT	p.F3487F		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	3487	Laminin G-like 4.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACAGCCGCTGAACCCGACGG	0.682													25	23	---	---	---	---	PASS
SLCO4A1	28231	broad.mit.edu	37	20	61288084	61288084	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:61288084C>T	uc002ydb.1	+	2	483	c.278C>T	c.(277-279)CCG>CTG	p.P93L	SLCO4A1_uc002ydc.1_RNA	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	93	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			GCCTTCGCACCGCCGTGCCTG	0.662													15	8	---	---	---	---	PASS
DIDO1	11083	broad.mit.edu	37	20	61525406	61525406	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr20:61525406C>T	uc002ydr.1	-	12	2977	c.2713G>A	c.(2713-2715)GAG>AAG	p.E905K	DIDO1_uc002yds.1_Missense_Mutation_p.E905K|DIDO1_uc002ydt.1_Missense_Mutation_p.E905K|DIDO1_uc002ydu.1_Missense_Mutation_p.E905K	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	905					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GGCACAGCCTCCGGCATCACC	0.502													36	116	---	---	---	---	PASS
RCAN1	1827	broad.mit.edu	37	21	35893803	35893803	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr21:35893803C>A	uc002yue.2	-	3	652	c.580G>T	c.(580-582)GGG>TGG	p.G194W	RCAN1_uc002yuc.2_Missense_Mutation_p.G113W|RCAN1_uc002yud.2_Missense_Mutation_p.G59W|RCAN1_uc002yub.2_Missense_Mutation_p.G139W|RCAN1_uc011adx.1_Missense_Mutation_p.G139W	NM_004414	NP_004405	P53805	RCAN1_HUMAN	calcipressin 1 isoform a	194					blood circulation|calcium-mediated signaling|central nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						TCACCTGGCCCCAGCTTGGAG	0.612													10	22	---	---	---	---	PASS
DGCR2	9993	broad.mit.edu	37	22	19055686	19055686	+	Silent	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr22:19055686C>A	uc002zoq.1	-	3	503	c.255G>T	c.(253-255)CGG>CGT	p.R85R	DGCR2_uc002zor.1_5'UTR|DGCR2_uc011agr.1_Silent_p.R44R	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	85	Extracellular (Potential).				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					CCCGCCCCTGCCGCGGATCCA	0.632													5	14	---	---	---	---	PASS
DGCR2	9993	broad.mit.edu	37	22	19055687	19055687	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr22:19055687C>A	uc002zoq.1	-	3	502	c.254G>T	c.(253-255)CGG>CTG	p.R85L	DGCR2_uc002zor.1_5'UTR|DGCR2_uc011agr.1_Missense_Mutation_p.R44L	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	85	Extracellular (Potential).				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					CCGCCCCTGCCGCGGATCCAC	0.627													6	12	---	---	---	---	PASS
KLHL22	84861	broad.mit.edu	37	22	20812204	20812204	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr22:20812204C>A	uc002zsl.1	-	5	1305	c.1196G>T	c.(1195-1197)AGG>ATG	p.R399M	KLHL22_uc011ahr.1_Missense_Mutation_p.R256M|KLHL22_uc002zsm.1_Missense_Mutation_p.R399M	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	399	Kelch 2.				cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GTAGATGTACCTGCCTACAAC	0.612													4	21	---	---	---	---	PASS
LOC96610	96610	broad.mit.edu	37	22	23135349	23135349	+	RNA	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr22:23135349G>T	uc011aim.1	+	251		c.11991G>T								Parts of antibodies, mostly variable regions.												0						CATGATTTATGATGTCAGTAA	0.552													29	427	---	---	---	---	PASS
SLC2A11	66035	broad.mit.edu	37	22	24225966	24225966	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr22:24225966T>C	uc002zyn.3	+	9	1091	c.992T>C	c.(991-993)GTA>GCA	p.V331A	SLC2A11_uc002zyl.1_3'UTR|SLC2A11_uc002zym.3_Missense_Mutation_p.V338A|SLC2A11_uc002zyo.3_RNA|SLC2A11_uc011ajc.1_Intron|SLC2A11_uc002zyp.3_Missense_Mutation_p.V334A	NM_001024938	NP_001020109	Q9BYW1	GTR11_HUMAN	glucose transporter protein 10 isoform c	331	Helical; Name=8; (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity			ovary(1)	1						CAGTGTGTGGTAATCGAGAGG	0.612													6	72	---	---	---	---	PASS
RFPL2	10739	broad.mit.edu	37	22	32588926	32588926	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr22:32588926C>A	uc003amg.3	-	4	1455	c.519G>T	c.(517-519)AAG>AAT	p.K173N	RFPL2_uc003ame.3_Missense_Mutation_p.K112N|RFPL2_uc003amf.3_Missense_Mutation_p.K83N|RFPL2_uc003amh.3_Missense_Mutation_p.K83N	NM_001098527	NP_001091997	O75678	RFPL2_HUMAN	ret finger protein-like 2 isoform 2	173	B30.2/SPRY.						zinc ion binding			skin(1)	1						TCTGCAGAATCTTCTTCAGCT	0.512													50	135	---	---	---	---	PASS
MCM5	4174	broad.mit.edu	37	22	35796559	35796559	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr22:35796559G>T	uc003anu.3	+	2	222	c.128G>T	c.(127-129)CGA>CTA	p.R43L	MCM5_uc010gwr.2_5'UTR|MCM5_uc003anv.3_Missense_Mutation_p.R43L	NM_006739	NP_006730	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	43					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)	1						CGGCAGTACCGAGTGGGCACC	0.672													10	20	---	---	---	---	PASS
RASD2	23551	broad.mit.edu	37	22	35943063	35943063	+	Silent	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr22:35943063C>G	uc003anx.2	+	2	412	c.207C>G	c.(205-207)CTC>CTG	p.L69L	RASD2_uc003any.2_Silent_p.L69L	NM_014310	NP_055125	Q96D21	RHES_HUMAN	RASD family, member 2 precursor	69					locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			lung(2)|skin(1)	3						TGTACCAGCTCGACATCCTGG	0.617													31	32	---	---	---	---	PASS
APOL5	80831	broad.mit.edu	37	22	36122449	36122449	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr22:36122449G>C	uc003aof.2	+	3	334	c.334G>C	c.(334-336)GAG>CAG	p.E112Q		NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5	112					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						GCACAAGTTTGAGCTAGAACA	0.458													6	66	---	---	---	---	PASS
CELSR1	9620	broad.mit.edu	37	22	46835291	46835291	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr22:46835291C>G	uc003bhw.1	-	3	4201	c.4201G>C	c.(4201-4203)GAT>CAT	p.D1401H		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1401	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GAGCGGGCATCCACCTCACAG	0.647													6	16	---	---	---	---	PASS
PLXNB2	23654	broad.mit.edu	37	22	50728775	50728775	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr22:50728775G>A	uc003bkv.3	-	3	345	c.239C>T	c.(238-240)CCG>CTG	p.P80L		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	80	Extracellular (Potential).|Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTCGATGGGCGGCGTGCACTT	0.652													9	15	---	---	---	---	PASS
SHOX	6473	broad.mit.edu	37	X	601814	601814	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chrX:601814T>C	uc004cph.1	+	5	1316	c.625T>C	c.(625-627)TTC>CTC	p.F209L	SHOX_uc004cpi.2_Missense_Mutation_p.F209L	NM_000451	NP_000442	O15266	SHOX_HUMAN	short stature homeobox isoform SHOXa	209					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACGGATGCCTTTCCAACAGGT	0.567													24	18	---	---	---	---	PASS
CSF2RA	1438	broad.mit.edu	37	X	1428351	1428351	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chrX:1428351G>C	uc010nct.2	+	14	1504	c.1182G>C	c.(1180-1182)TTG>TTC	p.L394F	CSF2RA_uc004cpq.2_3'UTR|CSF2RA_uc004cpn.2_Missense_Mutation_p.L394F|CSF2RA_uc004cpo.2_Missense_Mutation_p.L394F|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_Missense_Mutation_p.L261F|CSF2RA_uc004cpp.2_Missense_Mutation_p.D335H|CSF2RA_uc010ncv.2_Missense_Mutation_p.L428F|CSF2RA_uc004cpr.2_3'UTR	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	394	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	AAGAGGTCTTGACCGTGAAGG	0.527													6	133	---	---	---	---	PASS
ASMT	438	broad.mit.edu	37	X	1743268	1743268	+	Nonsense_Mutation	SNP	G	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chrX:1743268G>A	uc004cqd.2	+	4	496	c.351G>A	c.(349-351)TGG>TGA	p.W117*	ASMT_uc010ncy.2_Nonsense_Mutation_p.W117*|ASMT_uc004cqe.2_Nonsense_Mutation_p.W117*	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	117					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACCGGTGCTGGGGCCACCTGG	0.662													9	80	---	---	---	---	PASS
MAGEB1	4112	broad.mit.edu	37	X	30269565	30269565	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chrX:30269565T>A	uc004dcc.2	+	4	1275	c.955T>A	c.(955-957)TCC>ACC	p.S319T	MAGEB1_uc004dcd.2_Missense_Mutation_p.S319T|MAGEB1_uc004dce.2_Missense_Mutation_p.S319T	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	319											0						CCAAGTCCGATCCAGTGTTAG	0.547													34	13	---	---	---	---	PASS
CXorf22	170063	broad.mit.edu	37	X	35969926	35969926	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chrX:35969926G>C	uc004ddj.2	+	6	951	c.892G>C	c.(892-894)GAT>CAT	p.D298H	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	298										large_intestine(1)|lung(1)|ovary(1)	3						ACAGGGTACAGATATTCAACA	0.269													9	5	---	---	---	---	PASS
SUV39H1	6839	broad.mit.edu	37	X	48564683	48564683	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chrX:48564683C>T	uc004dkn.2	+	4	901	c.856C>T	c.(856-858)CGG>TGG	p.R286W	SUV39H1_uc011mmf.1_Missense_Mutation_p.R297W|SUV39H1_uc011mmg.1_RNA	NM_003173	NP_003164	O43463	SUV91_HUMAN	suppressor of variegation 3-9 homolog 1	286	Mediates interaction with MECOM (By similarity).|SET.				cell cycle|cell differentiation|chromatin silencing at rDNA|interspecies interaction between organisms|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|chromosome, centromeric region|condensed nuclear chromosome|rDNA heterochromatin	chromatin binding|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|zinc ion binding				0						GGCAGAGCGGCGGGGCCAGAT	0.592													5	21	---	---	---	---	PASS
KIAA2022	340533	broad.mit.edu	37	X	73963358	73963358	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chrX:73963358C>A	uc004eby.2	-	3	1651	c.1034G>T	c.(1033-1035)TGC>TTC	p.C345F		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	345					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TCGCTTGGGGCAGGTAGTAAA	0.463													27	7	---	---	---	---	PASS
CXorf26	51260	broad.mit.edu	37	X	75397617	75397617	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chrX:75397617G>C	uc004ecl.1	+	6	779	c.576G>C	c.(574-576)GAG>GAC	p.E192D		NM_016500	NP_057584	Q9BVG4	CX026_HUMAN	hypothetical protein LOC51260	192											0						atggaggagagaaaggagctg	0.040													14	5	---	---	---	---	PASS
DCX	1641	broad.mit.edu	37	X	110574147	110574147	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chrX:110574147C>T	uc004epd.2	-	5	1346	c.1174G>A	c.(1174-1176)GCA>ACA	p.A392T	DCX_uc011msv.1_Missense_Mutation_p.G392S|DCX_uc004epe.2_Missense_Mutation_p.A311T|DCX_uc004epf.2_Missense_Mutation_p.G311S|DCX_uc004epg.2_Missense_Mutation_p.A311T	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	392	Pro/Ser-rich.				axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						TGGTCGTTACCTGAGTCAGCT	0.527													75	30	---	---	---	---	PASS
CXorf61	203413	broad.mit.edu	37	X	115593069	115593069	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chrX:115593069C>A	uc004eqj.1	-	2	301	c.181G>T	c.(181-183)GAC>TAC	p.D61Y		NM_001017978	NP_001017978	Q5H943	KKLC1_HUMAN	chromosome X open reading frame 61	61	Extracellular (Potential).					integral to membrane|plasma membrane					0						CGAGAGAGGTCGTAGACTGCA	0.418													26	8	---	---	---	---	PASS
NKAP	79576	broad.mit.edu	37	X	119064021	119064021	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chrX:119064021A>C	uc004esh.2	-	8	1198	c.1031T>G	c.(1030-1032)ATT>AGT	p.I344S	NKAP_uc004esg.2_Missense_Mutation_p.I231S	NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	344	Necessary for interaction with HDAC3 and transcriptional repression.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						AAATGATGCAATTTCTTCACT	0.393													13	42	---	---	---	---	PASS
LOC388692	388692	broad.mit.edu	37	1	149285546	149285547	+	RNA	INS	-	A	A	rs144216017	by1000genomes	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:149285546_149285547insA	uc010pbf.1	+	1		c.6071_6072insA			LOC388692_uc001esg.3_5'Flank	NR_027002				Homo sapiens cDNA FLJ13580 fis, clone PLACE1008851.												0						ttctgtctctcaaaaaaaaTGC	0.163													8	4	---	---	---	---	
LOC388692	388692	broad.mit.edu	37	1	149287128	149287129	+	RNA	DEL	CT	-	-	rs140343451		TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:149287128_149287129delCT	uc010pbf.1	+	1		c.7653_7654delCT			LOC388692_uc001esg.3_5'Flank	NR_027002				Homo sapiens cDNA FLJ13580 fis, clone PLACE1008851.												0						GGGGACTGGCCTCTCTGCACGG	0.594													4	4	---	---	---	---	
SPTA1	6708	broad.mit.edu	37	1	158619725	158619725	+	Frame_Shift_Del	DEL	G	-	-			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr1:158619725delG	uc001fst.1	-	25	3689	c.3490delC	c.(3490-3492)CGCfs	p.R1164fs		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1164	Spectrin 11.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GAACCCCAGCGGGAATTCAAT	0.443													23	10	---	---	---	---	
Unknown	0	broad.mit.edu	37	3	184900714	184900714	+	RNA	DEL	A	-	-			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr3:184900714delA	uc003fpe.2	+	6		c.1133delA								Homo sapiens hypothetical LOC339926, mRNA (cDNA clone IMAGE:4838153).																		actttggaacaaaaggacaaa	0.000													4	2	---	---	---	---	
ABCB5	340273	broad.mit.edu	37	7	20795082	20795082	+	Frame_Shift_Del	DEL	G	-	-	rs61999295	byFrequency	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr7:20795082delG	uc003suw.3	+	19	2820	c.2274delG	c.(2272-2274)ACGfs	p.T758fs	ABCB5_uc010kuh.2_Frame_Shift_Del_p.T1203fs	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	758	Cytoplasmic (Potential).|ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						AAGCCAGGACGGGAAGGACAT	0.448													25	13	---	---	---	---	
AQP7P1	375719	broad.mit.edu	37	9	67289313	67289314	+	RNA	INS	-	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr9:67289313_67289314insT	uc004aen.1	-	1		c.179_180insA			AQP7P1_uc004aeo.1_RNA|AQP7P1_uc004aep.1_RNA					Homo sapiens cDNA FLJ46364 fis, clone TESTI4051015.												0						AGCTATCCCTGTGTCCCCAGTC	0.614													5	3	---	---	---	---	
NID2	22795	broad.mit.edu	37	14	52520416	52520416	+	Frame_Shift_Del	DEL	G	-	-			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr14:52520416delG	uc001wzo.2	-	5	1544	c.1310delC	c.(1309-1311)CCAfs	p.P437fs	NID2_uc010tqs.1_Frame_Shift_Del_p.P437fs|NID2_uc010tqt.1_Frame_Shift_Del_p.P437fs|NID2_uc001wzp.2_Frame_Shift_Del_p.P437fs	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	437						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					AGGATGAGCTGGGGGAACATC	0.547													46	26	---	---	---	---	
SPATA7	55812	broad.mit.edu	37	14	88892994	88892995	+	Frame_Shift_Ins	INS	-	A	A			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr14:88892994_88892995insA	uc001xwq.2	+	6	942_943	c.791_792insA	c.(790-792)AGAfs	p.R264fs	SPATA7_uc001xwr.2_Frame_Shift_Ins_p.R232fs|SPATA7_uc001xws.2_Frame_Shift_Ins_p.R200fs|SPATA7_uc001xwt.2_Frame_Shift_Ins_p.R158fs|SPATA7_uc001xwu.2_5'Flank	NM_018418	NP_060888	Q9P0W8	SPAT7_HUMAN	spermatogenesis-associated protein 7 isoform a	264					response to stimulus|visual perception					ovary(1)	1						CCTGCCAAAAGAAAAAAGGATT	0.366													34	19	---	---	---	---	
Unknown	0	broad.mit.edu	37	15	40617717	40617717	+	RNA	DEL	T	-	-	rs3214686		TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr15:40617717delT	uc001zlf.1	+	1		c.1037delT								Homo sapiens cDNA FLJ41776 fis, clone IMR322013053.																		TGTTTTTATCTTTTTTTTTTT	0.448													5	4	---	---	---	---	
IQGAP1	8826	broad.mit.edu	37	15	91010776	91010776	+	Frame_Shift_Del	DEL	T	-	-	rs1505936	byFrequency	TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr15:91010776delT	uc002bpl.1	+	18	2231	c.2130delT	c.(2128-2130)CCTfs	p.P710fs		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	710	WW.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			GGGatgaacctccaaattttg	0.323													49	52	---	---	---	---	
PRKCA	5578	broad.mit.edu	37	17	64738846	64738847	+	Frame_Shift_Ins	INS	-	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr17:64738846_64738847insC	uc002jfp.1	+	13	1536_1537	c.1492_1493insC	c.(1492-1494)TTCfs	p.F498fs	PRKCA_uc002jfo.1_Frame_Shift_Ins_p.F369fs	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	498	Protein kinase.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	GACCAGGACCTTCTGTGGGACT	0.475													22	39	---	---	---	---	
DPP9	91039	broad.mit.edu	37	19	4704256	4704257	+	Frame_Shift_Ins	INS	-	C	C			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr19:4704256_4704257insC	uc002mba.2	-	6	744_745	c.486_487insG	c.(484-489)CGCCTGfs	p.R162fs	DPP9_uc002mbb.2_Frame_Shift_Ins_p.R162fs|DPP9_uc002mbc.2_Frame_Shift_Ins_p.R162fs	NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	133_134					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		AAGACCCCCAGGCGTTTCCGCT	0.644													37	22	---	---	---	---	
Unknown	0	broad.mit.edu	37	22	20292917	20292918	+	RNA	INS	-	T	T			TCGA-18-3414-01A-01D-0983-08	TCGA-18-3414-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	239deee9-2791-4163-b777-fdf8c49c9e33	dc33f835-cd00-493e-98a9-48aa6b4ef73f	g.chr22:20292917_20292918insT	uc002zrw.1	+	1		c.1357_1358insT								Homo sapiens mRNA for KIAA1653 protein, partial cds.																		ctggctgtggcttgggcttttt	0.000													5	3	---	---	---	---