Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
CASP9	842	broad.mit.edu	37	1	15833532	15833532	+	Silent	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:15833532G>A	uc001awn.2	-	4	587	c.492C>T	c.(490-492)CTC>CTT	p.L164L	CASP9_uc001awm.1_Silent_p.L164L|CASP9_uc001awo.2_Intron|CASP9_uc001awp.2_Silent_p.L8L|CASP9_uc009voi.2_Silent_p.L8L|CASP9_uc010obm.1_Silent_p.L81L|CASP9_uc001awq.2_Silent_p.L81L	NM_001229	NP_001220	P55211	CASP9_HUMAN	caspase 9 isoform alpha preproprotein	164					activation of caspase activity by cytochrome c|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol	cysteine-type endopeptidase activity|enzyme activator activity|protein binding			central_nervous_system(1)|kidney(1)	2		Breast(348;0.000207)|all_lung(284;0.000211)|Colorectal(325;0.000259)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;8.49e-07)|COAD - Colon adenocarcinoma(227;4.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00013)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00763)|READ - Rectum adenocarcinoma(331;0.0655)		TGTTGATAATGAGGCAGTGGC	0.612													27	111	---	---	---	---	PASS
C1orf144	26099	broad.mit.edu	37	1	16721555	16721555	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:16721555G>A	uc001aym.3	+	4	549	c.379G>A	c.(379-381)GAA>AAA	p.E127K	C1orf144_uc010ocb.1_Missense_Mutation_p.E107K|C1orf144_uc001ayi.3_Missense_Mutation_p.E108K|C1orf144_uc001ayk.3_Missense_Mutation_p.E107K	NM_001114600	NP_001108072	Q7Z422	CA144_HUMAN	putative MAPK activating protein PM20,PM21	127											0		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(227;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;4.12e-05)|Kidney(64;0.00018)|KIRC - Kidney renal clear cell carcinoma(64;0.00267)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		CTCCCAACCCGAAGACAGCAG	0.448													12	57	---	---	---	---	PASS
ARID1A	8289	broad.mit.edu	37	1	27092947	27092947	+	Splice_Site	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:27092947G>C	uc001bmv.1	+	10	3252	c.2879_splice	c.e10-1	p.G960_splice	ARID1A_uc001bmt.1_Splice_Site_p.G960_splice|ARID1A_uc001bmu.1_Splice_Site_p.G960_splice|ARID1A_uc001bmw.1_Splice_Site_p.G577_splice	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a						androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CTCTTTTACAGGGATGGCAGC	0.448			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								20	36	---	---	---	---	PASS
ARID1A	8289	broad.mit.edu	37	1	27092948	27092948	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:27092948G>T	uc001bmv.1	+	10	3252	c.2879G>T	c.(2878-2880)GGG>GTG	p.G960V	ARID1A_uc001bmt.1_Missense_Mutation_p.G960V|ARID1A_uc001bmu.1_Missense_Mutation_p.G960V|ARID1A_uc001bmw.1_Missense_Mutation_p.G577V	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	960					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TCTTTTACAGGGATGGCAGCC	0.448			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								18	36	---	---	---	---	PASS
MAP3K6	9064	broad.mit.edu	37	1	27682928	27682928	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:27682928C>T	uc001bny.1	-	26	3837	c.3588G>A	c.(3586-3588)CAG>CAA	p.Q1196Q	MAP3K6_uc009vsw.1_Silent_p.Q1188Q	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	1196	Potential.				activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CATTCAGCCGCTGTAGAGCCC	0.612													19	28	---	---	---	---	PASS
LCK	3932	broad.mit.edu	37	1	32740636	32740636	+	Missense_Mutation	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:32740636A>T	uc001bux.2	+	4	368	c.230A>T	c.(229-231)GAC>GTC	p.D77V	LCK_uc001buy.2_Missense_Mutation_p.D77V|LCK_uc001buz.2_Missense_Mutation_p.D77V|LCK_uc010ohc.1_Missense_Mutation_p.D121V|LCK_uc001bva.2_Missense_Mutation_p.D135V	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	77	SH3.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	CCCTCTCACGACGGAGATCTG	0.597			T	TRB@	T-ALL								19	104	---	---	---	---	PASS
COL9A2	1298	broad.mit.edu	37	1	40767500	40767500	+	Silent	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:40767500C>A	uc001cfh.1	-	31	1924	c.1854G>T	c.(1852-1854)GGG>GGT	p.G618G	COL9A2_uc001cfi.1_Silent_p.G437G	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor	618	Triple-helical region 2 (COL2).				axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			TCCCTGGGGGCCCAGGCATCC	0.557													14	17	---	---	---	---	PASS
PTPRF	5792	broad.mit.edu	37	1	44056825	44056825	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:44056825G>A	uc001cjr.2	+	9	1472	c.1132G>A	c.(1132-1134)GGC>AGC	p.G378S	PTPRF_uc001cjs.2_Missense_Mutation_p.G378S|PTPRF_uc001cju.2_5'UTR|PTPRF_uc009vwt.2_5'UTR|PTPRF_uc001cjv.2_5'UTR	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	378	Extracellular (Potential).|Fibronectin type-III 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CAGCATTGGCGGCCTCAGCCC	0.662													40	55	---	---	---	---	PASS
PTPRF	5792	broad.mit.edu	37	1	44072012	44072012	+	Silent	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:44072012G>A	uc001cjr.2	+	20	3925	c.3585G>A	c.(3583-3585)CCG>CCA	p.P1195P	PTPRF_uc001cjs.2_Silent_p.P1186P|PTPRF_uc001cju.2_Silent_p.P573P|PTPRF_uc009vwt.2_Silent_p.P755P|PTPRF_uc001cjv.2_Silent_p.P655P|PTPRF_uc001cjw.2_Silent_p.P421P	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1195	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATGTGCTCCCGGAGACCTTTA	0.597													105	141	---	---	---	---	PASS
L1TD1	54596	broad.mit.edu	37	1	62672649	62672649	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:62672649G>T	uc001dae.3	+	3	651	c.349G>T	c.(349-351)GGG>TGG	p.G117W		NM_019079	NP_061952	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	117										ovary(1)|skin(1)	2						agggatggtagggaaaataga	0.050													62	97	---	---	---	---	PASS
KANK4	163782	broad.mit.edu	37	1	62740445	62740445	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:62740445G>C	uc001dah.3	-	3	708	c.331C>G	c.(331-333)CCG>GCG	p.P111A	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	111										ovary(3)|skin(2)|lung(1)	6						TTACCAAGCGGTGGTGACTGG	0.622													8	63	---	---	---	---	PASS
DOCK7	85440	broad.mit.edu	37	1	63018566	63018566	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:63018566C>G	uc001daq.2	-	22	2637	c.2603G>C	c.(2602-2604)GGG>GCG	p.G868A	DOCK7_uc001dan.2_Missense_Mutation_p.G760A|DOCK7_uc001dao.2_Missense_Mutation_p.G760A|DOCK7_uc001dap.2_Missense_Mutation_p.G868A|DOCK7_uc001dam.2_Missense_Mutation_p.G48A	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	868					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						TCCCAAACCCCCAGGACCTAG	0.388													14	25	---	---	---	---	PASS
LRRC7	57554	broad.mit.edu	37	1	70502271	70502271	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:70502271C>T	uc001dep.2	+	18	2168	c.2138C>T	c.(2137-2139)GCT>GTT	p.A713V	LRRC7_uc009wbg.2_Intron|LRRC7_uc001deq.2_5'UTR	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	713						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CAGACAACAGCTAAAGATGCA	0.433													55	108	---	---	---	---	PASS
LRRIQ3	127255	broad.mit.edu	37	1	74648482	74648482	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:74648482G>A	uc001dfy.3	-	3	505	c.313C>T	c.(313-315)CAT>TAT	p.H105Y	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	105	LRR 3.									ovary(2)	2						CCATTGTCATGAAGATAGAGT	0.308													21	30	---	---	---	---	PASS
PTGFR	5737	broad.mit.edu	37	1	79002362	79002362	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:79002362C>T	uc001din.2	+	3	1336	c.1070C>T	c.(1069-1071)GCA>GTA	p.A357V	PTGFR_uc001dim.2_3'UTR	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	357	Cytoplasmic (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	GAGAAATCAGCAAGCACCTAG	0.383													9	42	---	---	---	---	PASS
GSTM4	2948	broad.mit.edu	37	1	110200278	110200278	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:110200278C>T	uc001dyf.2	+	4	558	c.244C>T	c.(244-246)CGC>TGC	p.R82C	GSTM4_uc001dyg.2_Intron|GSTM4_uc009wfj.2_Intron|GSTM4_uc001dyh.2_Missense_Mutation_p.R82C|GSTM2_uc001dyi.2_Intron	NM_000850	NP_000841	Q03013	GSTM4_HUMAN	glutathione S-transferase mu 4 isoform 1	82	GST N-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0123)|Colorectal(144;0.0129)|Epithelial(280;0.0147)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.0471)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	CTACATTGCCCGCAAGCACAA	0.567													52	207	---	---	---	---	PASS
DCLRE1B	64858	broad.mit.edu	37	1	114454011	114454011	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:114454011C>T	uc001eeg.2	+	4	968	c.797C>T	c.(796-798)CCT>CTT	p.P266L	DCLRE1B_uc001eeh.2_Missense_Mutation_p.P140L|DCLRE1B_uc001eei.2_Missense_Mutation_p.P140L	NM_022836	NP_073747	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B (PSO2 homolog, S.	266					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding				0	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGCTCCCACCCTGATATCCAC	0.527								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					61	67	---	---	---	---	PASS
CHD1L	9557	broad.mit.edu	37	1	146765333	146765333	+	Silent	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:146765333C>G	uc001epm.3	+	21	2496	c.2433C>G	c.(2431-2433)GTC>GTG	p.V811V	uc001epp.2_Intron|CHD1L_uc001epn.3_Silent_p.V698V|CHD1L_uc010ozo.1_RNA|CHD1L_uc009wjg.2_RNA|CHD1L_uc009wjh.2_Silent_p.V717V|CHD1L_uc010ozp.1_Silent_p.V530V|CHD1L_uc001epo.3_Silent_p.V607V|CHD1L_uc009wji.2_Silent_p.V530V	NM_004284	NP_004275	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein	811	Macro.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(3)|lung(2)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.0487)					GTTCCAATGTCCTGTCTGGCA	0.463													20	329	---	---	---	---	PASS
HRNR	388697	broad.mit.edu	37	1	152187683	152187683	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:152187683C>T	uc001ezt.1	-	3	6498	c.6422G>A	c.(6421-6423)GGA>GAA	p.G2141E		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2141					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGATGACTGTCCTGATCTAGA	0.587													24	744	---	---	---	---	PASS
FLG	2312	broad.mit.edu	37	1	152277980	152277980	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:152277980G>T	uc001ezu.1	-	3	9418	c.9382C>A	c.(9382-9384)CAT>AAT	p.H3128N		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3128	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTACCGAATGCTCGTGGTGG	0.592									Ichthyosis				106	317	---	---	---	---	PASS
FLG	2312	broad.mit.edu	37	1	152278956	152278956	+	Missense_Mutation	SNP	G	C	C	rs137870179	byFrequency	TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:152278956G>C	uc001ezu.1	-	3	8442	c.8406C>G	c.(8404-8406)CAC>CAG	p.H2802Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2802	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGAATGCTCGTGGTGGTACC	0.597									Ichthyosis				85	492	---	---	---	---	PASS
FLG	2312	broad.mit.edu	37	1	152284451	152284451	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:152284451G>A	uc001ezu.1	-	3	2947	c.2911C>T	c.(2911-2913)CGT>TGT	p.R971C	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	971	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCAGATCCACGATGGTTTCTG	0.577									Ichthyosis				19	578	---	---	---	---	PASS
NES	10763	broad.mit.edu	37	1	156640164	156640164	+	Silent	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:156640164G>T	uc001fpq.2	-	4	3949	c.3816C>A	c.(3814-3816)CCC>CCA	p.P1272P		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1272	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGGGGCCCTCGGGGATCTCCC	0.642													76	142	---	---	---	---	PASS
OR10Z1	128368	broad.mit.edu	37	1	158576908	158576908	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:158576908G>T	uc010pio.1	+	1	680	c.680G>T	c.(679-681)AGG>ATG	p.R227M		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					GCAATACTGAGGATCCCCTCT	0.507													111	180	---	---	---	---	PASS
SPTA1	6708	broad.mit.edu	37	1	158590127	158590127	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:158590127C>A	uc001fst.1	-	44	6449	c.6250G>T	c.(6250-6252)GAC>TAC	p.D2084Y		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2084	Spectrin 20.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCCTCATGGTCTTTCTGCAGC	0.488													27	59	---	---	---	---	PASS
C1orf125	126859	broad.mit.edu	37	1	179452290	179452290	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:179452290G>T	uc001gmo.2	+	18	2152	c.2025G>T	c.(2023-2025)ATG>ATT	p.M675I	C1orf125_uc009wxg.2_RNA|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.M675I	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	675											0						TATTTAACATGATTCAACAAT	0.328													27	55	---	---	---	---	PASS
CEP350	9857	broad.mit.edu	37	1	180013242	180013242	+	Missense_Mutation	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:180013242A>T	uc001gnt.2	+	21	4939	c.4556A>T	c.(4555-4557)CAT>CTT	p.H1519L	CEP350_uc009wxl.2_Missense_Mutation_p.H1518L	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1519	Ser-rich.					centrosome|nucleus|spindle				ovary(4)	4						GACTCAAAGCATCAGAAGTAT	0.333													7	5	---	---	---	---	PASS
PRG4	10216	broad.mit.edu	37	1	186270769	186270769	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:186270769G>A	uc001gru.3	+	4	296	c.245G>A	c.(244-246)AGG>AAG	p.R82K	PRG4_uc001grt.3_Missense_Mutation_p.R41K|PRG4_uc009wyl.2_Missense_Mutation_p.R82K|PRG4_uc009wym.2_Missense_Mutation_p.R41K|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	82	SMB 2.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						GAGAGAGGGAGGGAGTGTGAC	0.488													8	84	---	---	---	---	PASS
CRB1	23418	broad.mit.edu	37	1	197298053	197298053	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:197298053C>T	uc001gtz.2	+	2	707	c.572C>T	c.(571-573)GCT>GTT	p.A191V	CRB1_uc010poz.1_Missense_Mutation_p.A122V|CRB1_uc001gty.1_Missense_Mutation_p.A191V|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.A191V|CRB1_uc010ppb.1_Missense_Mutation_p.A191V	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	191	Extracellular (Potential).|EGF-like 5; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GATGAATGTGCTTCAGATCCC	0.458													19	30	---	---	---	---	PASS
CHIT1	1118	broad.mit.edu	37	1	203192314	203192314	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:203192314G>T	uc001gzn.2	-	6	650	c.554C>A	c.(553-555)CCA>CAA	p.P185Q	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_Intron|CHIT1_uc009xal.1_5'UTR|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Missense_Mutation_p.P176Q	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	185					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						CTGCCCAGCTGGAACCGCTGC	0.572													48	96	---	---	---	---	PASS
CR2	1380	broad.mit.edu	37	1	207646467	207646467	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:207646467C>G	uc001hfw.2	+	10	2015	c.1921C>G	c.(1921-1923)CAG>GAG	p.Q641E	CR2_uc001hfv.2_Missense_Mutation_p.Q641E|CR2_uc009xch.2_Missense_Mutation_p.Q641E|CR2_uc009xci.1_Missense_Mutation_p.Q126E	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	641	Sushi 10.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						GGGCAGTAGTCAGATTCGTTG	0.383													33	69	---	---	---	---	PASS
CAMK1G	57172	broad.mit.edu	37	1	209768392	209768392	+	Missense_Mutation	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:209768392A>G	uc001hhd.2	+	2	166	c.64A>G	c.(64-66)ACC>GCC	p.T22A	CAMK1G_uc001hhf.3_Missense_Mutation_p.T22A|CAMK1G_uc001hhe.2_Missense_Mutation_p.T22A	NM_020439	NP_065172	Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	22						Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		CATCCGGAAAACCTTCATTTT	0.512													4	84	---	---	---	---	PASS
KCNH1	3756	broad.mit.edu	37	1	211192568	211192568	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:211192568G>T	uc001hib.2	-	6	759	c.589C>A	c.(589-591)CAG>AAG	p.Q197K	KCNH1_uc001hic.2_Missense_Mutation_p.Q197K	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	197	Cytoplasmic (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TGCTTGTACTGGGGAAGGATG	0.428													33	81	---	---	---	---	PASS
C1orf69	200205	broad.mit.edu	37	1	228362694	228362694	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:228362694G>T	uc001hsl.3	+	2	732	c.643G>T	c.(643-645)GAC>TAC	p.D215Y	C1orf69_uc010pvw.1_Missense_Mutation_p.D22Y	NM_001010867	NP_001010867	Q5T440	CAF17_HUMAN	hypothetical protein LOC200205 precursor	215					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity				0		Prostate(94;0.0405)				CCGGCTCGGGGACTTGTGGGA	0.657													9	24	---	---	---	---	PASS
TRIM11	81559	broad.mit.edu	37	1	228584678	228584678	+	Nonsense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:228584678C>A	uc001hss.2	-	5	1084	c.829G>T	c.(829-831)GGA>TGA	p.G277*	TRIM11_uc010pvx.1_Nonsense_Mutation_p.G276*|TRIM11_uc001hst.1_Nonsense_Mutation_p.G277*	NM_145214	NP_660215	Q96F44	TRI11_HUMAN	tripartite motif-containing 11	277	B30.2/SPRY.				response to virus	cytoplasm|nucleus	protein binding|zinc ion binding	p.G277*(1)		lung(3)|ovary(1)	4		Prostate(94;0.0724)				TCTACCAGTCCCGGGACCCTG	0.637													18	29	---	---	---	---	PASS
RYR2	6262	broad.mit.edu	37	1	237919649	237919649	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:237919649C>A	uc001hyl.1	+	81	11327	c.11207C>A	c.(11206-11208)GCG>GAG	p.A3736E	RYR2_uc010pya.1_Missense_Mutation_p.A151E	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3736					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GATCGTGGCGCGGCTGAGATG	0.478													18	39	---	---	---	---	PASS
FMN2	56776	broad.mit.edu	37	1	240255947	240255947	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:240255947G>T	uc010pyd.1	+	1	763	c.538G>T	c.(538-540)GAC>TAC	p.D180Y	FMN2_uc010pye.1_Missense_Mutation_p.D180Y	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	180					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTCGGGCTCGGACACGGACAT	0.552													12	48	---	---	---	---	PASS
WDR64	128025	broad.mit.edu	37	1	241964483	241964483	+	Missense_Mutation	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:241964483T>A	uc001hzf.1	+	17	2024	c.1871T>A	c.(1870-1872)CTG>CAG	p.L624Q	WDR64_uc001hzg.1_Missense_Mutation_p.L537Q	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	1071										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			CAAATAAATCTGGCTTCTTCC	0.383													30	103	---	---	---	---	PASS
CEP170	9859	broad.mit.edu	37	1	243329005	243329005	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:243329005G>T	uc001hzs.2	-	13	2665	c.2257C>A	c.(2257-2259)CAA>AAA	p.Q753K	CEP170_uc001hzt.2_Missense_Mutation_p.Q655K|CEP170_uc001hzu.2_Missense_Mutation_p.Q655K|CEP170_uc001hzv.1_Missense_Mutation_p.Q131K	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	753						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			TCCTCCCTTTGTTCTTGTTGT	0.383													16	226	---	---	---	---	PASS
TRIM58	25893	broad.mit.edu	37	1	248039277	248039277	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:248039277G>C	uc001ido.2	+	6	995	c.947G>C	c.(946-948)GGA>GCA	p.G316A	OR2W3_uc001idp.1_5'UTR	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	316	B30.2/SPRY.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GTGCAGGATGGAGAACCATGG	0.587													6	61	---	---	---	---	PASS
OR2L8	391190	broad.mit.edu	37	1	248112246	248112246	+	Silent	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:248112246C>G	uc001idt.1	+	1	87	c.87C>G	c.(85-87)CTC>CTG	p.L29L	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TCTTCATTCTCATTGTTTTCA	0.388													49	167	---	---	---	---	PASS
OR2L13	284521	broad.mit.edu	37	1	248263294	248263294	+	Missense_Mutation	SNP	T	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:248263294T>C	uc001ids.2	+	3	954	c.617T>C	c.(616-618)CTC>CCC	p.L206P		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	206	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			AGCCTCTTTCTCCTTTTCCCT	0.443													35	78	---	---	---	---	PASS
OR2M4	26245	broad.mit.edu	37	1	248402623	248402623	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:248402623G>C	uc010pzh.1	+	1	393	c.393G>C	c.(391-393)CAG>CAC	p.Q131H		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACCCTCTTCAGTACACCATCC	0.473													35	77	---	---	---	---	PASS
OR2T33	391195	broad.mit.edu	37	1	248436434	248436434	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr1:248436434G>T	uc010pzi.1	-	1	683	c.683C>A	c.(682-684)TCT>TAT	p.S228Y		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GGCTTCTGTAGAGCGCATGTG	0.512													9	45	---	---	---	---	PASS
ROCK2	9475	broad.mit.edu	37	2	11426670	11426670	+	Nonsense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:11426670G>A	uc002rbd.1	-	3	768	c.319C>T	c.(319-321)CAG>TAG	p.Q107*		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	107	Protein kinase.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		CTTACCAACTGCACTTCACCA	0.318													11	187	---	---	---	---	PASS
MSGN1	343930	broad.mit.edu	37	2	17997991	17997991	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:17997991G>T	uc010yjt.1	+	1	206	c.206G>T	c.(205-207)TGT>TTT	p.C69F		NM_001105569	NP_001099039	A6NI15	MSGN1_HUMAN	mesogenin 1	69					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GGGCTGCCCTGTGAGCACGGC	0.617													17	96	---	---	---	---	PASS
NLRC4	58484	broad.mit.edu	37	2	32477621	32477621	+	Nonsense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:32477621G>T	uc002roi.2	-	3	375	c.129C>A	c.(127-129)TGC>TGA	p.C43*	NLRC4_uc002roj.1_Nonsense_Mutation_p.C43*|NLRC4_uc010ezt.1_Nonsense_Mutation_p.C43*	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	43	CARD.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CCACCTTCTCGCAGCAAATGA	0.403													18	165	---	---	---	---	PASS
BCL11A	53335	broad.mit.edu	37	2	60688573	60688573	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:60688573C>T	uc002sae.1	-	4	1702	c.1474G>A	c.(1474-1476)GAG>AAG	p.E492K	BCL11A_uc002sab.2_Missense_Mutation_p.E492K|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Missense_Mutation_p.E161K|BCL11A_uc010ypj.1_Missense_Mutation_p.E458K|BCL11A_uc002sad.1_Missense_Mutation_p.E340K|BCL11A_uc002saf.1_Missense_Mutation_p.E458K	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	492	Glu-rich.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			tcctcttcctcgtcgtcctcc	0.428			T	IGH@	B-CLL								4	28	---	---	---	---	PASS
MTHFD2	10797	broad.mit.edu	37	2	74425778	74425778	+	Missense_Mutation	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:74425778A>G	uc002skk.2	+	1	89	c.10A>G	c.(10-12)ACT>GCT	p.T4A	MTHFD2_uc002skj.2_5'UTR|MTHFD2_uc010yro.1_5'UTR|MTHFD2_uc010ffb.2_Missense_Mutation_p.T4A|MTHFD2_uc010yrp.1_5'UTR	NM_006636	NP_006627	P13995	MTDC_HUMAN	methylenetetrahydrofolate dehydrogenase 2	4					folic acid-containing compound biosynthetic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|phosphate binding|protein binding				0					NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TATGGCTGCGACTTCTCTAAT	0.701													6	18	---	---	---	---	PASS
REG1B	5968	broad.mit.edu	37	2	79312345	79312345	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:79312345G>T	uc002sny.2	-	6	610	c.498C>A	c.(496-498)AAC>AAA	p.N166K		NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	166					cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						GCTTCCTCTAGTTTTTGAACT	0.378													37	64	---	---	---	---	PASS
CTNNA2	1496	broad.mit.edu	37	2	80620418	80620418	+	Splice_Site	SNP	T	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:80620418T>C	uc010ysh.1	+	7	1142	c.1137_splice	c.e7+2	p.Q379_splice	CTNNA2_uc010yse.1_Splice_Site_p.Q379_splice|CTNNA2_uc010ysf.1_Splice_Site_p.Q379_splice|CTNNA2_uc010ysg.1_Splice_Site_p.Q379_splice|CTNNA2_uc010ysi.1_Splice_Site_p.Q11_splice	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1						axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AGGAGACAGGTACTATTTTTT	0.343													13	157	---	---	---	---	PASS
RPIA	22934	broad.mit.edu	37	2	89049497	89049497	+	Splice_Site	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:89049497G>T	uc002ste.2	+	9	880	c.839_splice	c.e9-1	p.G280_splice		NM_144563	NP_653164	P49247	RPIA_HUMAN	ribose 5-phosphate isomerase A						pentose-phosphate shunt, non-oxidative branch	cytosol	ribose-5-phosphate isomerase activity			ovary(1)	1		Acute lymphoblastic leukemia(2;0.000456)|all_hematologic(2;0.00287)				TTGTCCTGCAGGTGTGGTGGA	0.478													21	61	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	89339774	89339774	+	RNA	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:89339774G>T	uc010ytr.1	-	64		c.6085C>A			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		TCAGGCTGCAGGCTGCTGATG	0.498													97	146	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	90212099	90212099	+	RNA	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:90212099C>A	uc010fhm.2	+	26		c.3523C>A								Parts of antibodies, mostly variable regions.																		GGCCAGGCTCCCAGGCTCCTC	0.592													9	116	---	---	---	---	PASS
ZAP70	7535	broad.mit.edu	37	2	98349354	98349354	+	Missense_Mutation	SNP	C	T	T	rs56403250		TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:98349354C>T	uc002syd.1	+	5	779	c.572C>T	c.(571-573)CCG>CTG	p.P191L	ZAP70_uc010yvf.1_Missense_Mutation_p.P191L|ZAP70_uc002sye.1_Missense_Mutation_p.P81L|ZAP70_uc002syf.1_5'Flank	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	191	SH2 2.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						AGGCTGAGGCCGCGGAAGGAG	0.637													6	63	---	---	---	---	PASS
IL1R2	7850	broad.mit.edu	37	2	102625053	102625053	+	Missense_Mutation	SNP	G	T	T	rs148522700		TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:102625053G>T	uc002tbm.2	+	2	245	c.16G>T	c.(16-18)GTG>TTG	p.V6L	IL1R2_uc002tbn.2_Missense_Mutation_p.V6L|IL1R2_uc002tbo.1_Missense_Mutation_p.V6L	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	6					immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	GCGCTTGTACGTGTTGGTAAT	0.532													28	300	---	---	---	---	PASS
SLC9A4	389015	broad.mit.edu	37	2	103148810	103148810	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:103148810G>T	uc002tbz.3	+	12	2517	c.2060G>T	c.(2059-2061)GGA>GTA	p.G687V		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	687	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						AGTGATCCAGGATCCCCATCC	0.453													6	126	---	---	---	---	PASS
SCTR	6344	broad.mit.edu	37	2	120204407	120204407	+	Silent	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:120204407G>A	uc002tma.2	-	11	1294	c.1068C>T	c.(1066-1068)ATC>ATT	p.I356I	SCTR_uc002tlz.2_Silent_p.I178I	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	356	Helical; Name=6; (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	AGGCGAAGACGATGTAGTGGA	0.592													19	133	---	---	---	---	PASS
POTEF	728378	broad.mit.edu	37	2	130832686	130832686	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:130832686G>T	uc010fmh.2	-	17	2759	c.2359C>A	c.(2359-2361)CAC>AAC	p.H787N		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	787	Actin-like.					cell cortex	ATP binding			skin(3)|ovary(2)	5						AAGGTGTGGTGCCAGATCTTC	0.592													25	72	---	---	---	---	PASS
POTEF	728378	broad.mit.edu	37	2	130872836	130872836	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:130872836C>T	uc010fmh.2	-	4	987	c.587G>A	c.(586-588)CGA>CAA	p.R196Q		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	196	ANK 1.					cell cortex	ATP binding			skin(3)|ovary(2)	5						AAGTTGACATCGTCTGTCCAG	0.413													4	123	---	---	---	---	PASS
CCDC115	84317	broad.mit.edu	37	2	131098596	131098596	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:131098596C>A	uc002tqy.1	-	4	539	c.315G>T	c.(313-315)AAG>AAT	p.K105N	CCDC115_uc002tqw.1_Missense_Mutation_p.K97N|CCDC115_uc010zaf.1_Missense_Mutation_p.K100N|CCDC115_uc002tqx.2_Missense_Mutation_p.K100N|CCDC115_uc002tqz.1_Missense_Mutation_p.K105N|IMP4_uc002tra.1_5'Flank	NM_032357	NP_115733	Q96NT0	CC115_HUMAN	coiled-coil domain containing 115	105						endosome|lysosome					0	Colorectal(110;0.1)					TAGTGGGGCCCTTGCGCCTCC	0.498													8	15	---	---	---	---	PASS
LCT	3938	broad.mit.edu	37	2	136570498	136570498	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:136570498G>C	uc002tuu.1	-	7	1747	c.1736C>G	c.(1735-1737)GCC>GGC	p.A579G		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	579	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		CCAAGTTCTGGCATGAGCCTT	0.478													11	25	---	---	---	---	PASS
THSD7B	80731	broad.mit.edu	37	2	138400099	138400099	+	Nonsense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:138400099G>T	uc002tva.1	+	20	3754	c.3754G>T	c.(3754-3756)GGA>TGA	p.G1252*	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GCCAACCCAAGGAGAAGGACG	0.507													8	102	---	---	---	---	PASS
LRP1B	53353	broad.mit.edu	37	2	141243020	141243020	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:141243020G>T	uc002tvj.1	-	59	10289	c.9317C>A	c.(9316-9318)ACA>AAA	p.T3106K		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3106	Extracellular (Potential).|LDL-receptor class B 29.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCTTTTTTCTGTGTCAGACCA	0.388										TSP Lung(27;0.18)			17	45	---	---	---	---	PASS
ZEB2	9839	broad.mit.edu	37	2	145157138	145157138	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:145157138C>A	uc002tvu.2	-	8	2096	c.1616G>T	c.(1615-1617)TGC>TTC	p.C539F	ZEB2_uc002tvv.2_Missense_Mutation_p.C533F|ZEB2_uc010zbm.1_Missense_Mutation_p.C510F|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Missense_Mutation_p.C568F	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	539						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		GCTCTGGAGGCAAGCTTTGGC	0.393													30	66	---	---	---	---	PASS
SCN1A	6323	broad.mit.edu	37	2	166892837	166892837	+	Silent	SNP	T	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:166892837T>C	uc010zcz.1	-	16	3135	c.3117A>G	c.(3115-3117)CCA>CCG	p.P1039P	SCN1A_uc002udo.3_Silent_p.P919P|SCN1A_uc010fpk.2_Silent_p.P891P	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1050						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GATCATCAAGTGGTTTAATTT	0.303													4	58	---	---	---	---	PASS
XIRP2	129446	broad.mit.edu	37	2	168102211	168102211	+	Nonsense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:168102211C>T	uc002udx.2	+	8	4327	c.4309C>T	c.(4309-4311)CGA>TGA	p.R1437*	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Nonsense_Mutation_p.R1262*|XIRP2_uc010fpq.2_Nonsense_Mutation_p.R1215*|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1262					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TAACTATATACGAACAGTAAG	0.338													4	52	---	---	---	---	PASS
XIRP2	129446	broad.mit.edu	37	2	168106300	168106300	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:168106300G>T	uc002udx.2	+	8	8416	c.8398G>T	c.(8398-8400)GTT>TTT	p.V2800F	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.V2625F|XIRP2_uc010fpq.2_Missense_Mutation_p.V2578F|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.V146F	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2625					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GCTCAAGATGGTTCCCAGGAA	0.413													10	56	---	---	---	---	PASS
ZDBF2	57683	broad.mit.edu	37	2	207172970	207172970	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:207172970G>A	uc002vbp.2	+	5	3968	c.3718G>A	c.(3718-3720)GGT>AGT	p.G1240S		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1240							nucleic acid binding|zinc ion binding			ovary(3)	3						TGAAGCTAAGGGTTTTGAAAT	0.428													5	46	---	---	---	---	PASS
PIKFYVE	200576	broad.mit.edu	37	2	209141537	209141537	+	Missense_Mutation	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:209141537A>G	uc002vcz.2	+	4	582	c.424A>G	c.(424-426)ATG>GTG	p.M142V	PIKFYVE_uc010fun.1_5'UTR|PIKFYVE_uc002vcy.1_Missense_Mutation_p.M142V|PIKFYVE_uc002vcv.2_Intron|PIKFYVE_uc002vcw.2_Missense_Mutation_p.M142V|PIKFYVE_uc002vcx.2_Intron	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	142					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						CAAGGAAATCATGGAGGGGAA	0.458													7	42	---	---	---	---	PASS
PIKFYVE	200576	broad.mit.edu	37	2	209190212	209190212	+	Missense_Mutation	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:209190212A>T	uc002vcz.2	+	20	2835	c.2677A>T	c.(2677-2679)ATT>TTT	p.I893F	PIKFYVE_uc010fun.1_Missense_Mutation_p.I574F|PIKFYVE_uc002vcy.1_Missense_Mutation_p.I837F	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	893					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						CCATTCCCTGATTGAGGGACG	0.493													17	77	---	---	---	---	PASS
SPHKAP	80309	broad.mit.edu	37	2	228996729	228996729	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:228996729G>C	uc002vpq.2	-	2	152	c.105C>G	c.(103-105)AGC>AGG	p.S35R	SPHKAP_uc002vpp.2_Missense_Mutation_p.S35R|SPHKAP_uc010zlx.1_Missense_Mutation_p.S35R	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	35						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TCCCCGGGCCGCTTCCTGAGC	0.468													11	144	---	---	---	---	PASS
NEU4	129807	broad.mit.edu	37	2	242757900	242757900	+	Silent	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr2:242757900C>A	uc010fzr.2	+	4	1067	c.981C>A	c.(979-981)GGC>GGA	p.G327G	NEU4_uc002wcl.2_RNA|NEU4_uc002wcm.2_Silent_p.G327G|NEU4_uc002wcn.1_Silent_p.G339G|NEU4_uc002wco.1_Silent_p.G327G|NEU4_uc002wcp.1_Silent_p.G339G	NM_080741	NP_542779	Q8WWR8	NEUR4_HUMAN	sialidase 4	327	Pro-rich.					lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		CCCGTGGAGGCCAGGTGCCTG	0.706													4	15	---	---	---	---	PASS
CNTN6	27255	broad.mit.edu	37	3	1415727	1415727	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:1415727C>A	uc003boz.2	+	16	2332	c.2065C>A	c.(2065-2067)CCA>ACA	p.P689T	CNTN6_uc011asj.1_Missense_Mutation_p.P617T|CNTN6_uc003bpa.2_Missense_Mutation_p.P689T	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	689	Fibronectin type-III 1.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		ACCAAGTGAACCATCAGAATT	0.373													29	41	---	---	---	---	PASS
WNT7A	7476	broad.mit.edu	37	3	13860570	13860570	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:13860570C>A	uc003bye.1	-	4	1226	c.921G>T	c.(919-921)ATG>ATT	p.M307I		NM_004625	NP_004616	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family,	307					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			ovary(2)|breast(1)	3						GCCCACAGCACATGAGGTCAC	0.647													28	35	---	---	---	---	PASS
TGFBR2	7048	broad.mit.edu	37	3	30713392	30713392	+	Silent	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:30713392A>G	uc003ceo.2	+	4	1099	c.717A>G	c.(715-717)ACA>ACG	p.T239T	TGFBR2_uc003cen.2_Silent_p.T264T	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	239	Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						ACCACAACACAGAGCTGCTGC	0.542													34	34	---	---	---	---	PASS
CCDC13	152206	broad.mit.edu	37	3	42754710	42754710	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:42754710C>T	uc003cly.3	-	14	1901	c.1817G>A	c.(1816-1818)CGC>CAC	p.R606H		NM_144719	NP_653320	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	606	Potential.									ovary(1)	1						TGGCTCCAGGCGTATCTTCTC	0.522													39	77	---	---	---	---	PASS
UBA7	7318	broad.mit.edu	37	3	49847489	49847489	+	Silent	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:49847489T>A	uc003cxr.2	-	14	1932	c.1761A>T	c.(1759-1761)TCA>TCT	p.S587S		NM_003335	NP_003326	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	587					ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		AAGCTGCAGCTGAGGCAGGGG	0.602													33	43	---	---	---	---	PASS
GNAT1	2779	broad.mit.edu	37	3	50231970	50231970	+	Missense_Mutation	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:50231970A>G	uc003cym.2	+	7	861	c.745A>G	c.(745-747)ATC>GTC	p.I249V	GNAT1_uc003cyl.2_Missense_Mutation_p.I249V	NM_144499	NP_653082	P11488	GNAT1_HUMAN	rod-type transducin alpha subunit	249					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|negative regulation of cyclic-nucleotide phosphodiesterase activity|rhodopsin mediated phototransduction|sensory perception of umami taste	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	acyl binding|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GDP binding|GTP binding|GTPase activity|protein kinase binding|signal transducer activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		GTTCAACAGCATCTGCAACCA	0.592											OREG0015580	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	29	---	---	---	---	PASS
NEK4	6787	broad.mit.edu	37	3	52777368	52777368	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:52777368C>A	uc003dfq.3	-	12	2193	c.2004G>T	c.(2002-2004)CAG>CAT	p.Q668H	NEK4_uc011bej.1_Missense_Mutation_p.Q579H|NEK4_uc003dfr.2_Missense_Mutation_p.Q622H	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	668					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		CGTAATGCACCTGAGTGACGC	0.517													68	114	---	---	---	---	PASS
ITIH1	3697	broad.mit.edu	37	3	52818337	52818337	+	Silent	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:52818337C>A	uc003dfs.2	+	11	1275	c.1251C>A	c.(1249-1251)CTC>CTA	p.L417L	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_Silent_p.L18L|ITIH1_uc010hmo.1_5'UTR	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	417	Hyaluronan-binding.|VWFA.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		CCCAAATCCTCAAGAACGTCC	0.602													7	13	---	---	---	---	PASS
PRICKLE2	166336	broad.mit.edu	37	3	64085468	64085468	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:64085468C>A	uc003dmf.2	-	8	2380	c.1794G>T	c.(1792-1794)CAG>CAT	p.Q598H		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	598						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CGCTCCGGAACTGCATGGACG	0.547													56	191	---	---	---	---	PASS
ROBO2	6092	broad.mit.edu	37	3	77626709	77626709	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:77626709G>T	uc003dpy.3	+	15	2915	c.2272G>T	c.(2272-2274)GTT>TTT	p.V758F	ROBO2_uc003dpz.2_Missense_Mutation_p.V762F|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.V762F	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	758	Fibronectin type-III 3.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AAGTATTAGTGTTTCCTGGGA	0.463													15	40	---	---	---	---	PASS
EPHA6	285220	broad.mit.edu	37	3	97251212	97251212	+	Silent	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:97251212A>T	uc010how.1	+	11	2254	c.2211A>T	c.(2209-2211)GGA>GGT	p.G737G	EPHA6_uc011bgo.1_RNA|EPHA6_uc011bgp.1_Silent_p.G103G|EPHA6_uc003drs.3_Silent_p.G129G|EPHA6_uc003drr.3_Silent_p.G129G|EPHA6_uc003drt.2_Silent_p.G129G|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	642	ATP (By similarity).|Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						GTGAATTTGGAGAAGTCTGTA	0.383													52	69	---	---	---	---	PASS
CPOX	1371	broad.mit.edu	37	3	98309859	98309859	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:98309859C>A	uc003dsx.2	-	2	790	c.697G>T	c.(697-699)GAT>TAT	p.D233Y	CPOX_uc011bgz.1_Missense_Mutation_p.D233Y	NM_000097	NP_000088	P36551	HEM6_HUMAN	coproporphyrinogen oxidase precursor	233						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity				0						GATTTACCATCTTTAGTCTTC	0.358													13	77	---	---	---	---	PASS
IMPG2	50939	broad.mit.edu	37	3	100962939	100962939	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:100962939C>G	uc003duq.1	-	13	2439	c.2236G>C	c.(2236-2238)GAT>CAT	p.D746H	IMPG2_uc011bhe.1_Missense_Mutation_p.D609H	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	746	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TGTTCCATATCCTCCCTTAGG	0.403													42	59	---	---	---	---	PASS
POLQ	10721	broad.mit.edu	37	3	121206386	121206386	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:121206386G>A	uc003eee.3	-	16	5521	c.5392C>T	c.(5392-5394)CCT>TCT	p.P1798S	POLQ_uc003eed.2_Missense_Mutation_p.P970S	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1798					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TCACTAATAGGGCTGTTGTCT	0.383								DNA_polymerases_(catalytic_subunits)					45	67	---	---	---	---	PASS
POLQ	10721	broad.mit.edu	37	3	121208373	121208373	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:121208373C>T	uc003eee.3	-	16	3534	c.3405G>A	c.(3403-3405)GAG>GAA	p.E1135E	POLQ_uc003eed.2_Silent_p.E307E	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1135					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TGACAATATGCTCCACAAAAT	0.353								DNA_polymerases_(catalytic_subunits)					4	114	---	---	---	---	PASS
ADCY5	111	broad.mit.edu	37	3	123166600	123166600	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:123166600G>T	uc003egh.1	-	1	793	c.793C>A	c.(793-795)CCG>ACG	p.P265T		NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	265					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		AGCTGGAGCGGGGGCCGCGCC	0.672													21	25	---	---	---	---	PASS
COL6A6	131873	broad.mit.edu	37	3	130289907	130289907	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:130289907G>T	uc010htl.2	+	6	2678	c.2647G>T	c.(2647-2649)GGT>TGT	p.G883C		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	883	VWFA 5.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CCAAGCCATGGGTGGCAGTAC	0.532													16	20	---	---	---	---	PASS
MRPL3	11222	broad.mit.edu	37	3	131208878	131208878	+	Missense_Mutation	SNP	G	A	A	rs148638602		TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:131208878G>A	uc003eoh.2	-	5	679	c.515C>T	c.(514-516)CCG>CTG	p.P172L	MRPL3_uc011blo.1_Missense_Mutation_p.P67L|MRPL3_uc011blp.1_Missense_Mutation_p.P199L	NM_007208	NP_009139	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	172					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome				0						TGTCTGTTTCGGCGGCAATCC	0.353													23	32	---	---	---	---	PASS
ZIC1	7545	broad.mit.edu	37	3	147130324	147130324	+	Nonsense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:147130324C>A	uc003ewe.2	+	2	1721	c.1002C>A	c.(1000-1002)TGC>TGA	p.C334*		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	334	C2H2-type 4.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CCTTCAAGTGCGAGTTTGAGG	0.493													20	55	---	---	---	---	PASS
SCHIP1	29970	broad.mit.edu	37	3	159606684	159606684	+	Missense_Mutation	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:159606684A>G	uc003fcs.1	+	6	1336	c.1270A>G	c.(1270-1272)ATT>GTT	p.I424V	SCHIP1_uc003fcq.1_Missense_Mutation_p.I500V|SCHIP1_uc003fcr.1_Missense_Mutation_p.I413V|SCHIP1_uc003fct.1_Missense_Mutation_p.I411V|SCHIP1_uc010hvz.1_Missense_Mutation_p.I384V|SCHIP1_uc003fcu.1_Missense_Mutation_p.I181V|SCHIP1_uc003fcv.1_Missense_Mutation_p.I197V	NM_014575	NP_055390	Q9P0W5	SCHI1_HUMAN	schwannomin interacting protein 1	424	Potential.					cytoplasm	identical protein binding|protein binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			AGACATGACTATTGGGCAGCT	0.378													33	63	---	---	---	---	PASS
SI	6476	broad.mit.edu	37	3	164757675	164757675	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:164757675C>A	uc003fei.2	-	19	2306	c.2244G>T	c.(2242-2244)CAG>CAT	p.Q748H		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	748	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TAGAGCCTACCTGTTTTAGAA	0.368										HNSCC(35;0.089)			57	86	---	---	---	---	PASS
SI	6476	broad.mit.edu	37	3	164764763	164764763	+	Missense_Mutation	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:164764763T>A	uc003fei.2	-	16	1815	c.1753A>T	c.(1753-1755)ATT>TTT	p.I585F		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	585	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CGGGTAAGAATGAAGCTTCTC	0.323										HNSCC(35;0.089)			18	60	---	---	---	---	PASS
WDR49	151790	broad.mit.edu	37	3	167248976	167248976	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:167248976C>T	uc003fev.1	-	9	1395	c.1089G>A	c.(1087-1089)GAG>GAA	p.E363E	WDR49_uc003feu.1_Silent_p.E188E|WDR49_uc011bpd.1_Silent_p.E427E|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	363										large_intestine(1)|ovary(1)|skin(1)	3						CAGTGTCAATCTCAAAGTTGC	0.423													25	72	---	---	---	---	PASS
SPATA16	83893	broad.mit.edu	37	3	172642054	172642054	+	Missense_Mutation	SNP	T	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:172642054T>C	uc003fin.3	-	8	1440	c.1282A>G	c.(1282-1284)ACA>GCA	p.T428A		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	428					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			TTCCCCATTGTCTCCATTTGC	0.338													49	68	---	---	---	---	PASS
NLGN1	22871	broad.mit.edu	37	3	173997368	173997368	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:173997368G>T	uc003fio.1	+	6	2000	c.1577G>T	c.(1576-1578)TGC>TTC	p.C526F	NLGN1_uc010hww.1_Missense_Mutation_p.C566F|NLGN1_uc003fip.1_Missense_Mutation_p.C526F	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	543	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			TTATTTCCTTGCAATTTCTCC	0.433													3	51	---	---	---	---	PASS
HTR3E	285242	broad.mit.edu	37	3	183822014	183822014	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:183822014G>C	uc010hxq.2	+	4	790	c.324G>C	c.(322-324)GAG>GAC	p.E108D	HTR3E_uc003fml.3_Missense_Mutation_p.E93D|HTR3E_uc003fmm.2_Missense_Mutation_p.E123D|HTR3E_uc010hxr.2_Missense_Mutation_p.E108D|HTR3E_uc003fmn.2_Missense_Mutation_p.E108D	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	108	Extracellular (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			AGGAATGTGAGGGCATCACGA	0.483													3	30	---	---	---	---	PASS
MASP1	5648	broad.mit.edu	37	3	186947550	186947550	+	Missense_Mutation	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:186947550A>G	uc003frh.1	-	11	1771	c.1439T>C	c.(1438-1440)CTA>CCA	p.L480P		NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	480	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		CTCCCTACCTAGAAGGGAGCC	0.552													13	24	---	---	---	---	PASS
HRASLS	57110	broad.mit.edu	37	3	192980878	192980878	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr3:192980878G>T	uc003fta.2	+	3	664	c.259G>T	c.(259-261)GAT>TAT	p.D87Y		NM_020386	NP_065119	Q9HDD0	HRSL1_HUMAN	HRAS-like suppressor	87											0	all_cancers(143;9.1e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000159)		CAATAAATACGATGAAACGTA	0.433													35	81	---	---	---	---	PASS
PDE6B	5158	broad.mit.edu	37	4	619461	619461	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:619461C>A	uc003gap.2	+	1	99	c.46C>A	c.(46-48)CCC>ACC	p.P16T	PDE6B_uc003gao.3_Missense_Mutation_p.P16T	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	16					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						ggaccagaaccccgattttgc	0.498													7	86	---	---	---	---	PASS
GAK	2580	broad.mit.edu	37	4	843832	843832	+	Nonsense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:843832C>A	uc003gbm.3	-	27	3881	c.3682G>T	c.(3682-3684)GAG>TAG	p.E1228*	GAK_uc003gbn.3_Nonsense_Mutation_p.E1149*|GAK_uc003gbk.3_Nonsense_Mutation_p.E25*|GAK_uc010ibi.2_Nonsense_Mutation_p.E453*|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Nonsense_Mutation_p.E1081*	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	1228					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		ATGTTCCGCTCCTTGCCCTCA	0.692													11	11	---	---	---	---	PASS
EVC2	132884	broad.mit.edu	37	4	5699345	5699345	+	Silent	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:5699345C>A	uc003gij.2	-	2	312	c.258G>T	c.(256-258)GTG>GTT	p.V86V	EVC2_uc011bwb.1_5'UTR|EVC2_uc003gik.2_Silent_p.V6V	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	86						integral to membrane				large_intestine(3)|ovary(2)	5						GACAGCATTCCACTTTGGGCC	0.398													4	40	---	---	---	---	PASS
TADA2B	93624	broad.mit.edu	37	4	7056326	7056326	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:7056326G>C	uc003gjw.3	+	2	959	c.808G>C	c.(808-810)GAG>CAG	p.E270Q	TADA2B_uc010idi.2_Missense_Mutation_p.E195Q	NM_152293	NP_689506	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2 (ADA2 homolog,	270					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding				0						GTCATGCAAGGAGTTTGATGA	0.517													3	46	---	---	---	---	PASS
CPZ	8532	broad.mit.edu	37	4	8602955	8602955	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:8602955G>T	uc003glm.2	+	3	353	c.227G>T	c.(226-228)AGC>ATC	p.S76I	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_5'UTR|CPZ_uc003glo.2_Missense_Mutation_p.S65I|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	76	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						GTGGAGGCCAGCTCCGAGTAC	0.647													31	37	---	---	---	---	PASS
USP17	391627	broad.mit.edu	37	4	9361052	9361052	+	RNA	SNP	T	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:9361052T>C	uc011bwn.1	+	1		c.944T>C				NM_001105662	NP_001099132			ubiquitin specific peptidase 17												0						ACATGACTTCTTGTCTATGTC	0.463													17	192	---	---	---	---	PASS
GABRA2	2555	broad.mit.edu	37	4	46312252	46312252	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:46312252C>T	uc003gxc.3	-	5	1170	c.497G>A	c.(496-498)TGC>TAC	p.C166Y	GABRA2_uc010igc.2_Missense_Mutation_p.C166Y|GABRA2_uc011bzc.1_Missense_Mutation_p.C111Y|GABRA2_uc003gxe.2_Missense_Mutation_p.C166Y	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	166	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GTGCATTGGGCATTCAGCTTG	0.378													22	91	---	---	---	---	PASS
COX7B2	170712	broad.mit.edu	37	4	46737132	46737132	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:46737132G>C	uc003gxf.2	-	3	258	c.78C>G	c.(76-78)AGC>AGG	p.S26R	COX7B2_uc010ige.2_RNA	NM_130902	NP_570972	Q8TF08	CX7B2_HUMAN	cytochrome c oxidase subunit VIIb2 precursor	26	Mitochondrial matrix (By similarity).					integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity				0						GTTTTACATGGCTATGTCTTG	0.438													6	101	---	---	---	---	PASS
COMMD8	54951	broad.mit.edu	37	4	47462294	47462294	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:47462294C>T	uc003gxi.2	-	2	97	c.89G>A	c.(88-90)GGC>GAC	p.G30D		NM_017845	NP_060315	Q9NX08	COMD8_HUMAN	COMM domain containing 8	30							protein binding				0						ACCACAAATGCCATCAATTAT	0.313													7	50	---	---	---	---	PASS
NFXL1	152518	broad.mit.edu	37	4	47857075	47857075	+	Splice_Site	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:47857075C>A	uc010igh.2	-	20	2598	c.2421_splice	c.e20+1	p.K807_splice	NFXL1_uc003gxo.2_Splice_Site_p.K132_splice|NFXL1_uc003gxp.2_Splice_Site_p.K807_splice|NFXL1_uc003gxq.3_Splice_Site|NFXL1_uc010igi.2_Splice_Site_p.K807_splice	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like							integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						AAAATATTTACCTTTTTTATT	0.214													21	57	---	---	---	---	PASS
CNGA1	1259	broad.mit.edu	37	4	47939383	47939383	+	Silent	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:47939383G>A	uc003gxt.3	-	11	1394	c.1128C>T	c.(1126-1128)GTC>GTT	p.V376V	uc003gxr.1_Intron|CNGA1_uc003gxu.2_Silent_p.V445V	NM_000087	NP_000078	P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1 isoform	376	Helical; Name=H5; (Potential).				response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			ovary(2)	2						CCACCACAAAGACATACTCAG	0.428													12	220	---	---	---	---	PASS
SCFD2	152579	broad.mit.edu	37	4	54011748	54011748	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:54011748C>A	uc003gzu.2	-	5	1447	c.1313G>T	c.(1312-1314)AGC>ATC	p.S438I	SCFD2_uc010igm.2_Missense_Mutation_p.S438I	NM_152540	NP_689753	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	438					protein transport|vesicle docking involved in exocytosis					ovary(2)|pancreas(1)	3			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			CTCCCCAATGCTCTAAAATAA	0.373													16	105	---	---	---	---	PASS
INTU	27152	broad.mit.edu	37	4	128605626	128605626	+	Missense_Mutation	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:128605626A>G	uc003ifk.1	+	7	1314	c.1244A>G	c.(1243-1245)TAT>TGT	p.Y415C	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	415										ovary(1)	1						AAATTTATGTATGGTTCTTTA	0.299													11	50	---	---	---	---	PASS
SPOCK3	50859	broad.mit.edu	37	4	167810281	167810281	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:167810281C>A	uc003iri.1	-	7	739	c.598G>T	c.(598-600)GCA>TCA	p.A200S	SPOCK3_uc011cjp.1_Nonsense_Mutation_p.G197*|SPOCK3_uc011cjq.1_Missense_Mutation_p.A209S|SPOCK3_uc011cjr.1_Missense_Mutation_p.A80S|SPOCK3_uc003irj.1_Missense_Mutation_p.A197S|SPOCK3_uc011cjs.1_Missense_Mutation_p.A149S|SPOCK3_uc011cjt.1_Missense_Mutation_p.A108S|SPOCK3_uc011cju.1_Missense_Mutation_p.A93S|SPOCK3_uc011cjv.1_Missense_Mutation_p.A102S|SPOCK3_uc003irk.3_Missense_Mutation_p.A197S|SPOCK3_uc011cjw.1_RNA	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	200					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		tGTCACTTACCTCTCTTAACA	0.333													14	72	---	---	---	---	PASS
MORF4	10934	broad.mit.edu	37	4	174537110	174537110	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:174537110C>T	uc011cke.1	-	1	685	c.685G>A	c.(685-687)GAG>AAG	p.E229K		NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		CGATGGTACTCAGGAAGAGCC	0.403													7	42	---	---	---	---	PASS
ODZ3	55714	broad.mit.edu	37	4	183601758	183601758	+	Missense_Mutation	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr4:183601758A>T	uc003ivd.1	+	9	1739	c.1702A>T	c.(1702-1704)AGC>TGC	p.S568C	ODZ3_uc003ive.1_5'UTR	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	568	Extracellular (Potential).|EGF-like 2.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CCTGTGTTTCAGCGGCTGGAA	0.552													12	72	---	---	---	---	PASS
ZDHHC11	79844	broad.mit.edu	37	5	850700	850700	+	Silent	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:850700C>A	uc011cma.1	-	1	402	c.18G>T	c.(16-18)GGG>GGT	p.G6G	ZDHHC11_uc003jbj.2_5'Flank	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	6						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			AACACTGGCTCCCGGAGCGGG	0.627													22	163	---	---	---	---	PASS
FLJ33360	401172	broad.mit.edu	37	5	6312505	6312505	+	Missense_Mutation	SNP	T	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:6312505T>C	uc003jdn.1	-	2	468	c.371A>G	c.(370-372)CAC>CGC	p.H124R		NM_001001702	NP_001001702			SubName: Full=FLJ33360 protein; SubName: Full=cDNA FLJ33360 fis, clone BRACE2005253;												0						AGCAGGGGAGTGCAATGTCCC	0.592													7	14	---	---	---	---	PASS
FBXL7	23194	broad.mit.edu	37	5	15936724	15936724	+	Missense_Mutation	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:15936724A>T	uc003jfn.1	+	4	1386	c.905A>T	c.(904-906)CAC>CTC	p.H302L		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	302	LRR 5.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CAGCTCACCCACCTCTACCTG	0.642													6	70	---	---	---	---	PASS
CDH18	1016	broad.mit.edu	37	5	19747089	19747089	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:19747089C>A	uc003jgc.2	-	3	862	c.485G>T	c.(484-486)GGA>GTA	p.G162V	CDH18_uc003jgd.2_Missense_Mutation_p.G162V|CDH18_uc011cnm.1_Missense_Mutation_p.G162V	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	162	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AATGTATGGTCCATCTGTGAA	0.348													59	127	---	---	---	---	PASS
CDH18	1016	broad.mit.edu	37	5	19747090	19747090	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:19747090C>T	uc003jgc.2	-	3	861	c.484G>A	c.(484-486)GGA>AGA	p.G162R	CDH18_uc003jgd.2_Missense_Mutation_p.G162R|CDH18_uc011cnm.1_Missense_Mutation_p.G162R	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	162	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					ATGTATGGTCCATCTGTGAAT	0.348													59	128	---	---	---	---	PASS
PRDM9	56979	broad.mit.edu	37	5	23527405	23527405	+	Silent	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:23527405C>A	uc003jgo.2	+	11	2390	c.2208C>A	c.(2206-2208)CTC>CTA	p.L736L		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	736	C2H2-type 9.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CACACCTCCTCAGACACCAGA	0.587										HNSCC(3;0.000094)			67	77	---	---	---	---	PASS
C7	730	broad.mit.edu	37	5	40955528	40955528	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:40955528G>T	uc003jmh.2	+	10	1247	c.1133G>T	c.(1132-1134)AGA>ATA	p.R378I	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	378	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				CCGTTCATCAGAGGGGGAGGT	0.418													92	189	---	---	---	---	PASS
TRIM23	373	broad.mit.edu	37	5	64913946	64913946	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:64913946G>A	uc003jty.2	-	2	304	c.218C>T	c.(217-219)CCA>CTA	p.P73L	TRIM23_uc003jtw.2_Missense_Mutation_p.P73L|TRIM23_uc003jtx.2_Missense_Mutation_p.P73L	NM_001656	NP_001647	P36406	TRI23_HUMAN	ADP-ribosylation factor domain protein 1 isoform	73	RING-type; degenerate.				interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		TCGATCAAATGGGCAACGGAT	0.418													19	28	---	---	---	---	PASS
MARVELD2	153562	broad.mit.edu	37	5	68728477	68728477	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:68728477C>A	uc003jwq.2	+	4	1365	c.1306C>A	c.(1306-1308)CCT>ACT	p.P436T	MARVELD2_uc010ixf.2_Missense_Mutation_p.P424T|MARVELD2_uc003jwr.1_Intron|MARVELD2_uc003jws.1_RNA	NM_001038603	NP_001033692	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2 isoform 1	436	Cytoplasmic (Potential).				sensory perception of sound	integral to membrane|tight junction					0		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)		CATTCCTAAACCTATCGTGAT	0.458													3	68	---	---	---	---	PASS
GPR98	84059	broad.mit.edu	37	5	90041472	90041472	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:90041472G>A	uc003kju.2	+	52	10930	c.10834G>A	c.(10834-10836)GAT>AAT	p.D3612N	GPR98_uc003kjt.2_Missense_Mutation_p.D1318N|GPR98_uc003kjv.2_Missense_Mutation_p.D1212N	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3612	Calx-beta 23.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TATCCTTGATGATACAGTTCC	0.348													21	64	---	---	---	---	PASS
LOX	4015	broad.mit.edu	37	5	121412588	121412588	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:121412588C>A	uc003ksu.2	-	2	1115	c.740G>T	c.(739-741)AGT>ATT	p.S247I	LOX_uc010jcp.2_5'Flank|LOX_uc010jcq.2_5'Flank|LOX_uc011cwk.1_Missense_Mutation_p.S17I|LOX_uc010jcr.2_Intron	NM_002317	NP_002308	P28300	LYOX_HUMAN	lysyl oxidase preproprotein	247	Lysyl-oxidase like.				protein modification process	extracellular space	copper ion binding|protein-lysine 6-oxidase activity			lung(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)|Ovarian(225;0.0814)|Breast(839;0.143)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;2.14e-11)|OV - Ovarian serous cystadenocarcinoma(64;7.87e-10)|all cancers(49;2.49e-09)|COAD - Colon adenocarcinoma(49;0.02)		CAGCCCGTACCTGGCCAGACA	0.602											OREG0016741	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	59	---	---	---	---	PASS
FBN2	2201	broad.mit.edu	37	5	127624178	127624178	+	Missense_Mutation	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:127624178A>T	uc003kuu.2	-	53	7148	c.6709T>A	c.(6709-6711)TGC>AGC	p.C2237S		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2237	EGF-like 37; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTGCAATTGCATTCAAAACTC	0.378													5	53	---	---	---	---	PASS
GDF9	2661	broad.mit.edu	37	5	132200015	132200015	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:132200015C>A	uc003kxz.1	-	1	463	c.211G>T	c.(211-213)GTT>TTT	p.V71F	GDF9_uc011cxj.1_Intron|UQCRQ_uc003kya.1_5'Flank	NM_005260	NP_005251	O60383	GDF9_HUMAN	growth differentiation factor 9 precursor	71					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			skin(1)	1		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCTCGCCCAACAGATAGAACT	0.507													38	69	---	---	---	---	PASS
PCDHA13	56136	broad.mit.edu	37	5	140261956	140261956	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:140261956G>A	uc003lif.2	+	1	103	c.103G>A	c.(103-105)GTC>ATC	p.V35I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.V35I|PCDHA13_uc003lid.2_Missense_Mutation_p.V35I	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	35	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACTACTCCGTCCCCGAGGA	0.667													54	90	---	---	---	---	PASS
PCDHGA4	56111	broad.mit.edu	37	5	140735556	140735556	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:140735556C>T	uc003ljq.1	+	1	789	c.789C>T	c.(787-789)ACC>ACT	p.T263T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Silent_p.T263T	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	263	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCTACTCACCGTAAAAGCCA	0.458													8	41	---	---	---	---	PASS
PCDHGB5	56101	broad.mit.edu	37	5	140778312	140778312	+	Missense_Mutation	SNP	T	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:140778312T>G	uc003lkf.1	+	1	618	c.618T>G	c.(616-618)AGT>AGG	p.S206R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.S206R	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	206	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACAACAGAGTTACCATCGTT	0.493													15	130	---	---	---	---	PASS
PPP2R2B	5521	broad.mit.edu	37	5	145979881	145979881	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:145979881C>A	uc003loe.2	-	7	1458	c.933G>T	c.(931-933)ATG>ATT	p.M311I	PPP2R2B_uc010jgm.2_Missense_Mutation_p.M300I|PPP2R2B_uc003log.3_Missense_Mutation_p.M311I|PPP2R2B_uc003lof.3_Missense_Mutation_p.M311I|PPP2R2B_uc003loi.3_Missense_Mutation_p.M314I|PPP2R2B_uc003loh.3_Missense_Mutation_p.M311I|PPP2R2B_uc003loj.3_Missense_Mutation_p.M291I|PPP2R2B_uc003lok.3_Missense_Mutation_p.M300I|PPP2R2B_uc011dbu.1_Missense_Mutation_p.M317I|PPP2R2B_uc011dbv.1_Missense_Mutation_p.M369I	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	311	WD 5.				apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGCGGTTTTCCATGTTGAGAT	0.473													51	84	---	---	---	---	PASS
SPINK5	11005	broad.mit.edu	37	5	147486684	147486684	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:147486684G>T	uc003lox.2	+	17	1637	c.1564G>T	c.(1564-1566)GGC>TGC	p.G522C	SPINK5_uc010jgs.1_Missense_Mutation_p.G494C|SPINK5_uc010jgr.2_Missense_Mutation_p.G503C|SPINK5_uc003low.2_Missense_Mutation_p.G522C|SPINK5_uc003loy.2_Missense_Mutation_p.G522C	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	522	Kazal-like 8.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCCCAGATGGCAAAATGCA	0.488													31	124	---	---	---	---	PASS
CSF1R	1436	broad.mit.edu	37	5	149439324	149439324	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:149439324G>T	uc003lrl.2	-	14	2266	c.2071C>A	c.(2071-2073)CAG>AAG	p.Q691K	CSF1R_uc011dcd.1_Intron|CSF1R_uc010jhc.2_Intron|CSF1R_uc003lrm.2_Missense_Mutation_p.Q691K	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	691	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	TCGGGGTCCTGGCCGGGGCTC	0.582													37	49	---	---	---	---	PASS
TCOF1	6949	broad.mit.edu	37	5	149772327	149772327	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:149772327G>A	uc003lry.2	+	22	3682	c.3574G>A	c.(3574-3576)GAG>AAG	p.E1192K	TCOF1_uc011dch.1_Missense_Mutation_p.E1155K|TCOF1_uc003lrz.2_Missense_Mutation_p.E1154K|TCOF1_uc003lrx.2_Missense_Mutation_p.E1116K|TCOF1_uc003lsa.2_Missense_Mutation_p.E1115K	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	1192					skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGAGTCCAGCGAGGATGATGT	0.637													15	25	---	---	---	---	PASS
FAM71B	153745	broad.mit.edu	37	5	156590666	156590666	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:156590666C>G	uc003lwn.2	-	2	710	c.610G>C	c.(610-612)GCA>CCA	p.A204P		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	204						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGAGCTCTGCAGCCTATACC	0.488													26	65	---	---	---	---	PASS
ADAM19	8728	broad.mit.edu	37	5	156915440	156915440	+	Missense_Mutation	SNP	G	T	T	rs150381064		TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:156915440G>T	uc003lwz.2	-	21	2447	c.2383C>A	c.(2383-2385)CCA>ACA	p.P795T	ADAM19_uc003lww.1_Missense_Mutation_p.P528T|ADAM19_uc003lwy.2_Missense_Mutation_p.P394T|ADAM19_uc011ddr.1_Missense_Mutation_p.P726T	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	795	Cytoplasmic (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGATAATCTGGAGGGGGCCGG	0.602													26	46	---	---	---	---	PASS
ODZ2	57451	broad.mit.edu	37	5	167589657	167589657	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:167589657C>A	uc010jjd.2	+	13	2437	c.2437C>A	c.(2437-2439)CTG>ATG	p.L813M	ODZ2_uc003lzr.3_Missense_Mutation_p.L590M|ODZ2_uc003lzt.3_Missense_Mutation_p.L186M|ODZ2_uc010jje.2_Missense_Mutation_p.L84M|uc003lzs.1_Intron	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GAGATGCACACTGGGTCAGAA	0.572													7	30	---	---	---	---	PASS
DOCK2	1794	broad.mit.edu	37	5	169461446	169461446	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:169461446G>T	uc003maf.2	+	35	3591	c.3511G>T	c.(3511-3513)GTG>TTG	p.V1171L	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.V663L	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1171	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGCCAAGTCGGTGGAGAACTT	0.572													12	45	---	---	---	---	PASS
NKX2-5	1482	broad.mit.edu	37	5	172659794	172659794	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:172659794G>T	uc003mcm.1	-	2	929	c.753C>A	c.(751-753)AAC>AAA	p.N251K		NM_004387	NP_004378	P52952	NKX25_HUMAN	NK2 transcription factor related, locus 5	251	Ala/Pro-rich.				adult heart development|atrial cardiac muscle cell development|atrial septum morphogenesis|heart looping|hemopoiesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell apoptosis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|outflow tract septum morphogenesis|pharyngeal system development|positive regulation of calcium ion transport via voltage-gated calcium channel activity|positive regulation of cardioblast differentiation|positive regulation of cell proliferation|positive regulation of heart contraction|positive regulation of neuron differentiation|positive regulation of sodium ion transport|positive regulation of survival gene product expression|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of cardiac muscle contraction|right ventricular cardiac muscle tissue morphogenesis|septum secundum development|spleen development|thyroid gland development|vasculogenesis|ventricular septum morphogenesis		chromatin binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CGGGGTAGGCGTTATAACCGT	0.706													5	15	---	---	---	---	PASS
LMAN2	10960	broad.mit.edu	37	5	176764785	176764785	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:176764785C>T	uc003mge.2	-	4	672	c.435G>A	c.(433-435)GGG>GGA	p.G145G	LMAN2_uc003mgd.2_Silent_p.G145G	NM_006816	NP_006807	Q12907	LMAN2_HUMAN	lectin, mannose-binding 2 precursor	145	Lumenal (Potential).|L-type lectin-like.				protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	metal ion binding|sugar binding				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAAACACAGGCCCTAGAATTA	0.522													3	31	---	---	---	---	PASS
ZNF454	285676	broad.mit.edu	37	5	178392666	178392666	+	Missense_Mutation	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr5:178392666T>A	uc003mjo.1	+	5	1532	c.1261T>A	c.(1261-1263)TTT>ATT	p.F421I	ZNF454_uc010jkz.1_Missense_Mutation_p.F421I	NM_182594	NP_872400	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	421	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		TGAGAAAGCCTTTCGGGACCA	0.428													26	18	---	---	---	---	PASS
C6orf201	404220	broad.mit.edu	37	6	4099236	4099236	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:4099236G>A	uc003mwa.3	+	3	856	c.88G>A	c.(88-90)GAG>AAG	p.E30K	C6orf201_uc003mvz.3_RNA|C6orf201_uc011dhw.1_Missense_Mutation_p.E30K|C6orf201_uc003mwb.3_RNA	NM_001085401	NP_001078870	Q7Z4U5	CF201_HUMAN	hypothetical protein LOC404220	30											0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				ATTACCAGGTGAGAATCCTGA	0.403													37	38	---	---	---	---	PASS
PECI	10455	broad.mit.edu	37	6	4131020	4131020	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:4131020G>T	uc003mwf.2	-	3	330	c.293C>A	c.(292-294)GCC>GAC	p.A98D	PECI_uc003mwc.2_5'UTR|PECI_uc003mwd.2_Missense_Mutation_p.A68D|PECI_uc003mwe.2_5'UTR|PECI_uc010jnr.1_RNA	NM_206836	NP_996667	O75521	ECI2_HUMAN	peroxisomal D3,D2-enoyl-CoA isomerase isoform 2	98	ACB.				fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding				0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				GCTGCCAAGGGCATTCCATGC	0.453													78	118	---	---	---	---	PASS
JARID2	3720	broad.mit.edu	37	6	15496845	15496845	+	Silent	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:15496845G>T	uc003nbj.2	+	7	1633	c.1389G>T	c.(1387-1389)GCG>GCT	p.A463A	JARID2_uc011diu.1_Silent_p.A327A|JARID2_uc011div.1_Silent_p.A291A|JARID2_uc011diw.1_Silent_p.A425A	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	463					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				TGAAAGGGGCGGCTGGCCCCG	0.667													15	21	---	---	---	---	PASS
SCAND3	114821	broad.mit.edu	37	6	28543242	28543242	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:28543242G>A	uc003nlo.2	-	3	1858	c.1240C>T	c.(1240-1242)CCT>TCT	p.P414S		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	414	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ACTTCCGTAGGCCTTTTAGAC	0.383													13	63	---	---	---	---	PASS
OR2J3	442186	broad.mit.edu	37	6	29080239	29080239	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:29080239C>T	uc011dll.1	+	1	572	c.572C>T	c.(571-573)TCG>TTG	p.S191L		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTGCGATTATCGTGTGTTGAT	0.458													11	108	---	---	---	---	PASS
OR12D2	26529	broad.mit.edu	37	6	29365010	29365010	+	Silent	SNP	T	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:29365010T>C	uc003nmf.3	+	1	595	c.534T>C	c.(532-534)GAT>GAC	p.D178D		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTCTCTGTGATATTAAGCCAT	0.478													20	191	---	---	---	---	PASS
ZFP57	346171	broad.mit.edu	37	6	29641277	29641277	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:29641277C>A	uc011dlw.1	-	4	762	c.611G>T	c.(610-612)AGC>ATC	p.S204I	ZFP57_uc003nnl.3_Missense_Mutation_p.S184I	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	120	C2H2-type 2.				DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						CTGACTGCAGCTGTTAGTCAG	0.537													13	123	---	---	---	---	PASS
MUC21	394263	broad.mit.edu	37	6	30954918	30954918	+	Silent	SNP	A	G	G	rs139721236		TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:30954918A>G	uc003nsh.2	+	2	1217	c.966A>G	c.(964-966)ACA>ACG	p.T322T	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	322	Ser-rich.|20.|28 X 15 AA approximate tandem repeats.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|skin(1)	2						ACTCCAGCACAACCTCCAGTG	0.617													5	121	---	---	---	---	PASS
C6orf15	29113	broad.mit.edu	37	6	31079265	31079265	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:31079265C>A	uc003nsk.1	-	2	871	c.871G>T	c.(871-873)GGT>TGT	p.G291C		NM_014070	NP_054789	Q6UXA7	CF015_HUMAN	STG protein precursor	291	Pro-rich.										0						TTATTGATACCTGGGTATAGA	0.527													36	85	---	---	---	---	PASS
UHRF1BP1	54887	broad.mit.edu	37	6	34826796	34826796	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:34826796C>A	uc003oju.3	+	14	2897	c.2663C>A	c.(2662-2664)CCC>CAC	p.P888H	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	888										ovary(3)	3						CATCCTGCACCCGGTGCTGTC	0.522													15	78	---	---	---	---	PASS
TREM1	54210	broad.mit.edu	37	6	41243864	41243864	+	Nonstop_Mutation	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:41243864T>A	uc003oqf.1	-	4	768	c.704A>T	c.(703-705)TAG>TTG	p.*235L	TREM1_uc003oqg.1_3'UTR	NM_018643	NP_061113	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	235					blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	TTCGTGGGCCTAGGGTACAAA	0.527													7	62	---	---	---	---	PASS
KLC4	89953	broad.mit.edu	37	6	43040989	43040989	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:43040989G>T	uc003otv.1	+	14	1735	c.1658G>T	c.(1657-1659)GGC>GTC	p.G553V	KLC4_uc003otr.1_RNA|KLC4_uc011dvd.1_Missense_Mutation_p.G476V|KLC4_uc003otw.1_Missense_Mutation_p.G571V|KLC4_uc003otx.1_Missense_Mutation_p.G553V|KLC4_uc003oty.1_Missense_Mutation_p.G553V|KLC4_uc003otz.1_Missense_Mutation_p.G553V	NM_201521	NP_958929	Q9NSK0	KLC4_HUMAN	kinesin-like 8 isoform a	553						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			skin(3)|ovary(1)	4			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			CAGAGGAGTGGCTCTCTTGGC	0.557													14	27	---	---	---	---	PASS
TMEM63B	55362	broad.mit.edu	37	6	44122607	44122607	+	Missense_Mutation	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:44122607A>G	uc003owr.2	+	24	2550	c.2486A>G	c.(2485-2487)GAG>GGG	p.E829G	TMEM63B_uc003ows.2_Missense_Mutation_p.E732G|TMEM63B_uc010jyz.2_RNA	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	829						integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			ATAGAGAATGAGATTCACCAG	0.562													16	42	---	---	---	---	PASS
GPR115	221393	broad.mit.edu	37	6	47678598	47678598	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:47678598C>A	uc003oza.1	+	4	534	c.276C>A	c.(274-276)AGC>AGA	p.S92R	GPR115_uc003oyz.1_Missense_Mutation_p.S149R|GPR115_uc003ozb.1_Missense_Mutation_p.S90R	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	92	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						CATGTACAAGCCTTTCTGTGG	0.393													28	37	---	---	---	---	PASS
C6orf138	442213	broad.mit.edu	37	6	47846323	47846323	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:47846323G>T	uc011dwm.1	-	3	2291	c.2206C>A	c.(2206-2208)CAA>AAA	p.Q736K	C6orf138_uc011dwn.1_Missense_Mutation_p.Q500K	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	753						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						CCATGGTCTTGCAAGGAGCTT	0.428													3	53	---	---	---	---	PASS
COL9A1	1297	broad.mit.edu	37	6	70981368	70981368	+	Missense_Mutation	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:70981368A>G	uc003pfg.3	-	14	1292	c.1133T>C	c.(1132-1134)GTA>GCA	p.V378A	COL9A1_uc003pfe.3_5'UTR|COL9A1_uc003pff.3_Missense_Mutation_p.V135A	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	378	Triple-helical region (COL3).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						AACAGGTCCTACACGGCCAAG	0.408													10	38	---	---	---	---	PASS
DSE	29940	broad.mit.edu	37	6	116756865	116756865	+	Nonsense_Mutation	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:116756865A>T	uc003pws.2	+	6	1428	c.1234A>T	c.(1234-1236)AGA>TGA	p.R412*	DSE_uc011ebg.1_Nonsense_Mutation_p.R431*|DSE_uc003pwt.2_Nonsense_Mutation_p.R412*|DSE_uc003pwu.2_Nonsense_Mutation_p.R79*	NM_001080976	NP_001074445	Q9UL01	DSE_HUMAN	dermatan sulfate epimerase precursor	412					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			ovary(1)	1		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		AGAAATCAATAGATCTTTCCT	0.433													7	67	---	---	---	---	PASS
TRDN	10345	broad.mit.edu	37	6	123892207	123892207	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:123892207C>T	uc003pzj.1	-	2	115	c.93G>A	c.(91-93)GTG>GTA	p.V31V	TRDN_uc003pzk.1_Silent_p.V31V|TRDN_uc003pzl.1_Silent_p.V31V|TRDN_uc010ken.2_Silent_p.V31V|TRDN_uc010keo.1_Silent_p.V31V	NM_006073	NP_006064	Q13061	TRDN_HUMAN	triadin	31	Cytoplasmic.				muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)		TCCTCTTCAGCACTTTTCCGG	0.463													26	66	---	---	---	---	PASS
C6orf58	352999	broad.mit.edu	37	6	127912763	127912763	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:127912763C>A	uc003qbh.2	+	6	1001	c.989C>A	c.(988-990)TCC>TAC	p.S330Y		NM_001010905	NP_001010905	Q6P5S2	CF058_HUMAN	hypothetical protein LOC352999 precursor	330						extracellular region					0				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		GGAAATAACTCCTGAAACATT	0.269													8	22	---	---	---	---	PASS
C6orf58	352999	broad.mit.edu	37	6	127912764	127912764	+	Silent	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:127912764C>A	uc003qbh.2	+	6	1002	c.990C>A	c.(988-990)TCC>TCA	p.S330S		NM_001010905	NP_001010905	Q6P5S2	CF058_HUMAN	hypothetical protein LOC352999 precursor	330						extracellular region					0				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		GAAATAACTCCTGAAACATTT	0.269													9	21	---	---	---	---	PASS
TMEM200A	114801	broad.mit.edu	37	6	130761578	130761578	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:130761578C>A	uc003qca.2	+	3	882	c.11C>A	c.(10-12)ACT>AAT	p.T4N	TMEM200A_uc010kfh.2_Missense_Mutation_p.T4N|TMEM200A_uc010kfi.2_Missense_Mutation_p.T4N|TMEM200A_uc003qcb.2_Missense_Mutation_p.T4N	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	4	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		ATGATAGCAACTGGTGGAGTG	0.448													38	79	---	---	---	---	PASS
ARG1	383	broad.mit.edu	37	6	131900371	131900371	+	Missense_Mutation	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:131900371T>A	uc003qcp.1	+	3	309	c.251T>A	c.(250-252)GTG>GAG	p.V84E	ARG1_uc003qco.1_Missense_Mutation_p.V84E|ARG1_uc010kfm.1_Missense_Mutation_p.V92E|MED23_uc003qcq.2_Intron	NM_000045	NP_000036	P05089	ARGI1_HUMAN	arginase 1	84					arginine catabolic process|urea cycle	cytosol	arginase activity			ovary(1)	1	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0106)|OV - Ovarian serous cystadenocarcinoma(155;0.0713)	L-Ornithine(DB00129)	GCTGGCAAGGTGGCAGAAGTC	0.512													15	42	---	---	---	---	PASS
TAAR6	319100	broad.mit.edu	37	6	132891689	132891689	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:132891689G>T	uc011eck.1	+	1	229	c.229G>T	c.(229-231)GCT>TCT	p.A77S		NM_175067	NP_778237	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	77	Helical; Name=2; (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(1)	3	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		TCTGGCCTGCGCTGATTTCTT	0.512													41	99	---	---	---	---	PASS
NMBR	4829	broad.mit.edu	37	6	142409428	142409428	+	Missense_Mutation	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:142409428T>A	uc003qiu.2	-	1	509	c.368A>T	c.(367-369)CAG>CTG	p.Q123L		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	123	Helical; Name=3; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		GGAAGTGAGCTGGATGACAGG	0.587													14	24	---	---	---	---	PASS
PDE10A	10846	broad.mit.edu	37	6	165848811	165848811	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr6:165848811G>T	uc003qun.2	-	7	662	c.421C>A	c.(421-423)CCT>ACT	p.P141T	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.P71T|PDE10A_uc003quo.2_Missense_Mutation_p.P151T	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	141	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GGCCCAGCAGGGATGAGGCGG	0.493													13	52	---	---	---	---	PASS
COL28A1	340267	broad.mit.edu	37	7	7557459	7557459	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:7557459G>C	uc003src.1	-	7	940	c.823C>G	c.(823-825)CAA>GAA	p.Q275E	COL28A1_uc011jxe.1_5'UTR|COL28A1_uc003srd.2_5'UTR	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	275					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		TCTCCTTTTTGAGCGTTGCCC	0.398													39	237	---	---	---	---	PASS
DNAH11	8701	broad.mit.edu	37	7	21940678	21940678	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:21940678C>G	uc003svc.2	+	83	13409	c.13378C>G	c.(13378-13380)CTG>GTG	p.L4460V	CDCA7L_uc003sve.3_3'UTR|CDCA7L_uc010kuk.2_3'UTR|CDCA7L_uc010kul.2_3'UTR|CDCA7L_uc003svf.3_3'UTR	NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4460					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCTCAAGGAGCTGGCATGCCC	0.537									Kartagener_syndrome				46	212	---	---	---	---	PASS
KLHL7	55975	broad.mit.edu	37	7	23205373	23205373	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:23205373C>T	uc003svs.3	+	8	1286	c.993C>T	c.(991-993)TGC>TGT	p.C331C	KLHL7_uc003svr.3_Silent_p.C309C|KLHL7_uc011jys.1_Silent_p.C255C|KLHL7_uc011jyt.1_Silent_p.C106C|KLHL7_uc003svt.2_Silent_p.C283C|KLHL7_uc011jyv.1_Silent_p.C106C	NM_001031710	NP_001026880	Q8IXQ5	KLHL7_HUMAN	kelch-like 7 isoform 1	331	Kelch 1.					Golgi apparatus|nucleolus|plasma membrane					0						ATGCAGCATGCGTGTTTTGGG	0.423													28	63	---	---	---	---	PASS
NEUROD6	63974	broad.mit.edu	37	7	31378677	31378677	+	Missense_Mutation	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:31378677T>A	uc003tch.2	-	2	559	c.206A>T	c.(205-207)GAT>GTT	p.D69V		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	69					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						CCCAttttcatcttcctcttc	0.358													45	215	---	---	---	---	PASS
ABCA13	154664	broad.mit.edu	37	7	48314352	48314352	+	Missense_Mutation	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:48314352A>G	uc003toq.2	+	17	5114	c.5089A>G	c.(5089-5091)AGT>GGT	p.S1697G	ABCA13_uc010kyr.2_Missense_Mutation_p.S1200G	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1697					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TAAGAATATCAGTAGTGTGGG	0.388													59	110	---	---	---	---	PASS
POM121L12	285877	broad.mit.edu	37	7	53103840	53103840	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:53103840G>A	uc003tpz.2	+	1	492	c.476G>A	c.(475-477)CGC>CAC	p.R159H		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	159											0						CAGAGAgcccgccccgcaggc	0.592													12	18	---	---	---	---	PASS
ZNF479	90827	broad.mit.edu	37	7	57187747	57187747	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:57187747G>T	uc010kzo.2	-	5	1646	c.1375C>A	c.(1375-1377)CAT>AAT	p.H459N		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	459	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TCTCCAGTATGAATTCTCTTG	0.428													36	117	---	---	---	---	PASS
ZNF680	340252	broad.mit.edu	37	7	63982404	63982404	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:63982404C>A	uc003tta.2	-	4	901	c.728G>T	c.(727-729)TGT>TTT	p.C243F	ZNF680_uc010kzr.2_Missense_Mutation_p.C170F	NM_178558	NP_848653	Q8NEM1	ZN680_HUMAN	zinc finger protein 680 isoform 1	243	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.118)|all_lung(88;0.243)				GGCTTTGCCACATTCCTCACA	0.363													12	23	---	---	---	---	PASS
CCL26	10344	broad.mit.edu	37	7	75401209	75401209	+	Silent	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:75401209C>A	uc003udt.1	-	3	294	c.186G>T	c.(184-186)GTG>GTT	p.V62V		NM_006072	NP_006063	Q9Y258	CCL26_HUMAN	chemokine (C-C motif) ligand 26 precursor	62					cell-cell signaling|chemotaxis|immune response|inflammatory response|positive regulation of actin filament polymerization|positive regulation of cell migration|positive regulation of endothelial cell proliferation|positive regulation of Rac GTPase activity|signal transduction	extracellular space	chemokine activity				0						ATACTCACATCACAGCCCGCT	0.567													16	67	---	---	---	---	PASS
POR	5447	broad.mit.edu	37	7	75614954	75614954	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:75614954G>A	uc003udy.2	+	13	1538	c.1456G>A	c.(1456-1458)GGC>AGC	p.G486S	POR_uc011kgc.1_Missense_Mutation_p.G294S|POR_uc011kgd.1_Missense_Mutation_p.G385S|POR_uc011kge.1_Missense_Mutation_p.G224S|POR_uc003uea.2_5'UTR	NM_000941	NP_000932	P16435	NCPR_HUMAN	cytochrome P450 reductase	483	FAD-binding FR-type.				cellular organofluorine metabolic process|positive regulation of monooxygenase activity	endoplasmic reticulum membrane	iron ion binding|NADPH-hemoprotein reductase activity			central_nervous_system(1)	1					Benzphetamine(DB00865)|Daunorubicin(DB00694)|Lipoic Acid(DB00166)|Menadione(DB00170)|Methoxyflurane(DB01028)|Mitomycin(DB00305)|Nilutamide(DB00665)	GACCAAGGCTGGCCGCATCAA	0.677													4	17	---	---	---	---	PASS
COL1A2	1278	broad.mit.edu	37	7	94047830	94047830	+	Missense_Mutation	SNP	G	T	T	rs72658154		TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:94047830G>T	uc003ung.1	+	33	2462	c.1991G>T	c.(1990-1992)GGT>GTT	p.G664V	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_RNA	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	664					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GGTCTCAGAGGTGAAATTGGT	0.333										HNSCC(75;0.22)			17	55	---	---	---	---	PASS
TRRAP	8295	broad.mit.edu	37	7	98552895	98552895	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:98552895C>T	uc003upp.2	+	40	6093	c.5884C>T	c.(5884-5886)CAC>TAC	p.H1962Y	TRRAP_uc011kis.1_Missense_Mutation_p.H1944Y|TRRAP_uc003upr.2_Missense_Mutation_p.H1661Y	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1962					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GCAGCTGGTCCACATTCTGCA	0.617													11	24	---	---	---	---	PASS
STAG3	10734	broad.mit.edu	37	7	99798772	99798772	+	Silent	SNP	T	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:99798772T>G	uc003utx.1	+	20	2276	c.2121T>G	c.(2119-2121)TCT>TCG	p.S707S	STAG3_uc010lgs.1_Silent_p.S495S|STAG3_uc011kjk.1_Silent_p.S649S|GATS_uc003uty.3_RNA|GATS_uc003utz.3_RNA|GATS_uc003uua.3_3'UTR|GATS_uc010lgt.2_RNA|STAG3_uc003uub.1_5'UTR	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	707					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AACGCCTCTCTGCCTTCTACA	0.478													21	75	---	---	---	---	PASS
SLC12A9	56996	broad.mit.edu	37	7	100459495	100459495	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:100459495G>T	uc003uwp.2	+	12	1815	c.1673G>T	c.(1672-1674)GGG>GTG	p.G558V	SLC12A9_uc003uwq.2_Missense_Mutation_p.G469V|SLC12A9_uc011kki.1_Missense_Mutation_p.G89V|SLC12A9_uc003uwr.2_Missense_Mutation_p.G294V|SLC12A9_uc003uws.2_Missense_Mutation_p.G89V|SLC12A9_uc003uwt.2_Missense_Mutation_p.G294V|SLC12A9_uc003uwv.2_Missense_Mutation_p.G89V	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	558	Extracellular (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)					AAGAAGGGGGGGCTGTATGTG	0.627													9	35	---	---	---	---	PASS
GRM8	2918	broad.mit.edu	37	7	126173297	126173297	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:126173297C>A	uc003vlr.2	-	8	2450	c.2139G>T	c.(2137-2139)TGG>TGT	p.W713C	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.W713C|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	713	Helical; Name=4; (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CCACAACAAACCAGACAAACA	0.517										HNSCC(24;0.065)			10	45	---	---	---	---	PASS
PAX4	5078	broad.mit.edu	37	7	127253856	127253856	+	Silent	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:127253856C>A	uc010lld.1	-	4	698	c.492G>T	c.(490-492)CGG>CGT	p.R164R	PAX4_uc003vmf.2_Silent_p.R162R|PAX4_uc003vmg.1_Silent_p.R164R|PAX4_uc003vmh.2_Silent_p.R162R	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	172	Homeobox.		R -> W (in MODY9; the mutant sequence represses the activity of the insulin and glucagon promoters by only 35% compared to 50% and 57% respectively with wild- type sequence).		cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TAGTCCGATTCCGGTGGCCGG	0.582													25	79	---	---	---	---	PASS
TSGA14	95681	broad.mit.edu	37	7	130038840	130038840	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:130038840C>A	uc003vpz.2	-	11	1061	c.1014G>T	c.(1012-1014)AAG>AAT	p.K338N	TSGA14_uc003vpy.2_Missense_Mutation_p.K100N|TSGA14_uc010lmf.2_Missense_Mutation_p.K135N|TSGA14_uc003vqa.2_Missense_Mutation_p.K266N|TSGA14_uc011kpg.1_Missense_Mutation_p.K250N	NM_018718	NP_061188	Q9BYV8	CEP41_HUMAN	testis specific, 14	338					G2/M transition of mitotic cell cycle	centrosome|cytosol					0	Melanoma(18;0.0435)					CACCAGGCACCTTGGACTCTC	0.592													63	221	---	---	---	---	PASS
TTC26	79989	broad.mit.edu	37	7	138862969	138862969	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:138862969C>T	uc003vus.2	+	13	1193	c.1079C>T	c.(1078-1080)CCA>CTA	p.P360L	TTC26_uc011kqn.1_Missense_Mutation_p.P360L|TTC26_uc011kqo.1_Missense_Mutation_p.P329L|TTC26_uc011kqp.1_Missense_Mutation_p.P255L|TTC26_uc003vut.2_Missense_Mutation_p.P220L|TTC26_uc011kqq.1_Missense_Mutation_p.P229L	NM_024926	NP_079202	A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26 isoform 1	360							binding			ovary(1)	1						GATACAATACCAGGGAGGCAG	0.348													13	45	---	---	---	---	PASS
OR9A2	135924	broad.mit.edu	37	7	142724074	142724074	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:142724074C>A	uc003wcc.1	-	1	146	c.146G>T	c.(145-147)TGT>TTT	p.C49F		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					TTTATCCACACAGACAATCAC	0.443													22	145	---	---	---	---	PASS
TPK1	27010	broad.mit.edu	37	7	144345919	144345919	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:144345919C>A	uc003weq.2	-	5	342	c.239G>T	c.(238-240)AGA>ATA	p.R80I	TPK1_uc003weo.2_Missense_Mutation_p.R75I|TPK1_uc003wep.2_RNA|TPK1_uc003wer.2_Missense_Mutation_p.R80I|TPK1_uc003wes.2_RNA	NM_022445	NP_071890	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1 isoform a	80					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			ovary(2)	2					Thiamine(DB00152)	ATAGTATTCTCTGACTTCAGG	0.308													38	185	---	---	---	---	PASS
CNTNAP2	26047	broad.mit.edu	37	7	146825794	146825794	+	Nonsense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:146825794G>T	uc003weu.1	+	7	1465	c.949G>T	c.(949-951)GGA>TGA	p.G317*		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	317	Laminin G-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GATAACCTTTGGAGGCATCCC	0.378										HNSCC(39;0.1)			17	98	---	---	---	---	PASS
CNTNAP2	26047	broad.mit.edu	37	7	146825795	146825795	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:146825795G>T	uc003weu.1	+	7	1466	c.950G>T	c.(949-951)GGA>GTA	p.G317V		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	317	Laminin G-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ATAACCTTTGGAGGCATCCCT	0.378										HNSCC(39;0.1)			18	98	---	---	---	---	PASS
CNTNAP2	26047	broad.mit.edu	37	7	146829519	146829519	+	Silent	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:146829519G>T	uc003weu.1	+	8	1782	c.1266G>T	c.(1264-1266)GTG>GTT	p.V422V		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	422	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGGGCAATGTGGAGATTGACC	0.458										HNSCC(39;0.1)			14	67	---	---	---	---	PASS
C7orf33	202865	broad.mit.edu	37	7	148288214	148288214	+	Missense_Mutation	SNP	G	A	A	rs79069436	by1000genomes	TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:148288214G>A	uc003wew.2	+	1	558	c.197G>A	c.(196-198)AGA>AAA	p.R66K		NM_145304	NP_660347	Q8WU49	CG033_HUMAN	hypothetical protein LOC202865	66										central_nervous_system(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GCCACGGGAAGACATAAGGTA	0.458													29	100	---	---	---	---	PASS
DPP6	1804	broad.mit.edu	37	7	154561142	154561142	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr7:154561142C>A	uc003wlk.2	+	9	1028	c.899C>A	c.(898-900)ACA>AAA	p.T300K	DPP6_uc003wli.2_Missense_Mutation_p.T236K|DPP6_uc003wlm.2_Missense_Mutation_p.T238K|DPP6_uc011kvq.1_Missense_Mutation_p.T193K	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	300	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			ATTTTGAAGACACACATCGCA	0.522													14	79	---	---	---	---	PASS
RP1L1	94137	broad.mit.edu	37	8	10466484	10466484	+	Silent	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:10466484C>A	uc003wtc.2	-	4	5353	c.5124G>T	c.(5122-5124)GTG>GTT	p.V1708V		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1708					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TGCCAGGGGCCACCTCTGCTG	0.647													33	84	---	---	---	---	PASS
RP1L1	94137	broad.mit.edu	37	8	10473979	10473979	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:10473979C>A	uc003wtc.2	-	3	957	c.728G>T	c.(727-729)GGG>GTG	p.G243V		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	243					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TGAAGTCAGCCCAGATAAAGT	0.527													12	72	---	---	---	---	PASS
NKX6-3	157848	broad.mit.edu	37	8	41504001	41504001	+	Silent	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:41504001G>A	uc003xoa.2	-	2	379	c.375C>T	c.(373-375)TTC>TTT	p.F125F	NKX6-3_uc010lxa.1_Silent_p.F125F	NM_152568	NP_689781	A6NJ46	NKX63_HUMAN	NK6 homeobox 3	255						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(28;0.00541)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Esophageal squamous(32;0.0844)|Hepatocellular(245;0.154)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TGAGCACCGAGAAGGCGGCGC	0.701													4	22	---	---	---	---	PASS
PREX2	80243	broad.mit.edu	37	8	69104587	69104587	+	Missense_Mutation	SNP	C	A	A	rs137974526		TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:69104587C>A	uc003xxv.1	+	37	4458	c.4431C>A	c.(4429-4431)AAC>AAA	p.N1477K		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1477					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GGCCTCTCAACGCTTTGGATG	0.433													10	55	---	---	---	---	PASS
SLCO5A1	81796	broad.mit.edu	37	8	70744061	70744061	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:70744061G>T	uc003xyl.2	-	2	1555	c.848C>A	c.(847-849)ACC>AAC	p.T283N	SLCO5A1_uc010lzb.2_Missense_Mutation_p.T283N|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.T283N|SLCO5A1_uc010lzc.2_Missense_Mutation_p.T283N	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	283	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TGGTCCCAGGGTATAAATAGG	0.453													19	137	---	---	---	---	PASS
TRPA1	8989	broad.mit.edu	37	8	72964988	72964988	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:72964988G>C	uc003xza.2	-	14	1832	c.1657C>G	c.(1657-1659)CAC>GAC	p.H553D	uc011lff.1_RNA|uc003xyy.2_RNA	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	553	Cytoplasmic (Potential).|ANK 14.					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GCAGCAAAGTGAAGTGCAGTG	0.458													92	121	---	---	---	---	PASS
PI15	51050	broad.mit.edu	37	8	75757390	75757390	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:75757390G>C	uc003yal.2	+	4	599	c.420G>C	c.(418-420)AAG>AAC	p.K140N	uc003yak.1_Intron|PI15_uc003yam.2_Missense_Mutation_p.K140N	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	140						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			AGTTGGTCAAGCCATGGTATG	0.393													24	152	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77616340	77616340	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:77616340C>A	uc003yav.2	+	2	404	c.17C>A	c.(16-18)TCC>TAC	p.S6Y	ZFHX4_uc003yat.1_Missense_Mutation_p.S6Y|ZFHX4_uc003yau.1_Missense_Mutation_p.S6Y|ZFHX4_uc003yaw.1_Missense_Mutation_p.S6Y	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	6						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACCTGTGACTCCCCTCCTATC	0.458										HNSCC(33;0.089)			12	38	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77767118	77767118	+	Missense_Mutation	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:77767118A>G	uc003yav.2	+	10	8213	c.7826A>G	c.(7825-7827)CAG>CGG	p.Q2609R	ZFHX4_uc003yau.1_Missense_Mutation_p.Q2654R|ZFHX4_uc003yaw.1_Missense_Mutation_p.Q2609R	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2609	Homeobox 3.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTCTGGTTCCAGAATACACGA	0.502										HNSCC(33;0.089)			23	129	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77775458	77775458	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:77775458C>A	uc003yav.2	+	11	9760	c.9373C>A	c.(9373-9375)CCT>ACT	p.P3125T		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3121	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			acctcctcctcctcctcctcc	0.363										HNSCC(33;0.089)			4	12	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77775459	77775459	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:77775459C>A	uc003yav.2	+	11	9761	c.9374C>A	c.(9373-9375)CCT>CAT	p.P3125H		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3121	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			cctcctcctcctcctcctcct	0.363										HNSCC(33;0.089)			4	14	---	---	---	---	PASS
CNGB3	54714	broad.mit.edu	37	8	87638275	87638275	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:87638275G>C	uc003ydx.2	-	13	1560	c.1514C>G	c.(1513-1515)ACG>AGG	p.T505R	CNGB3_uc010maj.2_Missense_Mutation_p.T367R	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	505	Helical; Name=H6; (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						TAACTGGACCGTAGTTGGTAG	0.383													25	58	---	---	---	---	PASS
POP1	10940	broad.mit.edu	37	8	99168595	99168595	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:99168595G>T	uc003yij.3	+	15	2475	c.2375G>T	c.(2374-2376)AGT>ATT	p.S792I	POP1_uc011lgv.1_Missense_Mutation_p.S792I|POP1_uc003yik.2_Missense_Mutation_p.S792I	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	792					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			CAGGAGGCCAGTGAAAACCAT	0.507													72	117	---	---	---	---	PASS
RIMS2	9699	broad.mit.edu	37	8	105105738	105105738	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:105105738G>A	uc003yls.2	+	21	3002	c.2761G>A	c.(2761-2763)GTT>ATT	p.V921I	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.V994I|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	375					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GGCAGATAATGTTTCTACTAA	0.408										HNSCC(12;0.0054)			11	256	---	---	---	---	PASS
ANGPT1	284	broad.mit.edu	37	8	108334131	108334131	+	Silent	SNP	T	C	C	rs138395811		TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:108334131T>C	uc003ymn.2	-	4	1269	c.801A>G	c.(799-801)AAA>AAG	p.K267K	ANGPT1_uc011lhv.1_Silent_p.K67K|ANGPT1_uc003ymo.2_Silent_p.K267K|ANGPT1_uc003ymp.3_Silent_p.K67K	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	267					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TACCACCTTCTTTAGTGCAAA	0.378													69	71	---	---	---	---	PASS
PKHD1L1	93035	broad.mit.edu	37	8	110376778	110376778	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:110376778G>A	uc003yne.2	+	2	180	c.76G>A	c.(76-78)GGC>AGC	p.G26S		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	26	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTTTCAGATGGCTCTCAAAT	0.348										HNSCC(38;0.096)			3	28	---	---	---	---	PASS
KCNV1	27012	broad.mit.edu	37	8	110986306	110986306	+	Silent	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:110986306G>A	uc003ynr.3	-	1	654	c.312C>T	c.(310-312)GAC>GAT	p.D104D	KCNV1_uc010mcw.2_Silent_p.D104D	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	104	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			GCGAGCTGCGGTCGAAGAAGT	0.662													16	23	---	---	---	---	PASS
ASAP1	50807	broad.mit.edu	37	8	131136348	131136348	+	Silent	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:131136348C>A	uc003yta.1	-	17	1546	c.1518G>T	c.(1516-1518)CTG>CTT	p.L506L	ASAP1_uc003ysz.1_Silent_p.L317L|ASAP1_uc011liw.1_Silent_p.L499L	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	506	Arf-GAP.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						CATTCTTGGCCAGCTGTAACA	0.328													60	82	---	---	---	---	PASS
TG	7038	broad.mit.edu	37	8	133961121	133961121	+	Silent	SNP	T	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:133961121T>G	uc003ytw.2	+	27	5375	c.5334T>G	c.(5332-5334)CCT>CCG	p.P1778P	TG_uc010mdw.2_Silent_p.P537P|TG_uc011ljb.1_Silent_p.P147P	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1778	Type IIIB.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTACATGTCCTGGTGTGACAT	0.483													17	173	---	---	---	---	PASS
SPATC1	375686	broad.mit.edu	37	8	145094893	145094893	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:145094893G>A	uc011lkw.1	+	2	397	c.295G>A	c.(295-297)GAG>AAG	p.E99K	SPATC1_uc011lkx.1_Missense_Mutation_p.E99K	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	99										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACCCCTGGCCGAGATGCTAAC	0.637													7	124	---	---	---	---	PASS
CPSF1	29894	broad.mit.edu	37	8	145624025	145624025	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:145624025C>G	uc003zcj.2	-	18	1717	c.1642G>C	c.(1642-1644)GAC>CAC	p.D548H		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	548					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			TTGGGATTGTCCTCCTGTCAG	0.652													4	147	---	---	---	---	PASS
ADAMTSL1	92949	broad.mit.edu	37	9	18574088	18574088	+	Nonsense_Mutation	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr9:18574088A>T	uc003zne.3	+	4	425	c.298A>T	c.(298-300)AAG>TAG	p.K100*	ADAMTSL1_uc003znb.2_Nonsense_Mutation_p.K100*|ADAMTSL1_uc003znc.3_Nonsense_Mutation_p.K100*	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	100						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		TAATGATGTCAAGCACCATGG	0.473													40	86	---	---	---	---	PASS
MLLT3	4300	broad.mit.edu	37	9	20414346	20414346	+	Silent	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr9:20414346G>A	uc003zoe.2	-	5	757	c.498C>T	c.(496-498)AGC>AGT	p.S166S	MLLT3_uc011lne.1_Silent_p.S134S|MLLT3_uc011lnf.1_Silent_p.S163S|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Missense_Mutation_p.A128V	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	166	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.134			T	MLL	ALL								4	32	---	---	---	---	PASS
GALNT12	79695	broad.mit.edu	37	9	101585705	101585705	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr9:101585705G>T	uc004ayz.2	+	2	539	c.539G>T	c.(538-540)AGA>ATA	p.R180I		NM_024642	NP_078918	Q8IXK2	GLT12_HUMAN	N-acetylgalactosaminyltransferase 12	180	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(62;0.0559)				TACAGTGATAGAGGTGAGTCC	0.537													31	38	---	---	---	---	PASS
OR13C8	138802	broad.mit.edu	37	9	107332380	107332380	+	Missense_Mutation	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr9:107332380T>A	uc011lvo.1	+	1	932	c.932T>A	c.(931-933)CTG>CAG	p.L311Q		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	311	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AAAAACATACTGTGTAGGAAA	0.358													38	33	---	---	---	---	PASS
IKBKAP	8518	broad.mit.edu	37	9	111679827	111679827	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr9:111679827C>A	uc004bdm.3	-	9	1384	c.864G>T	c.(862-864)AAG>AAT	p.K288N	IKBKAP_uc004bdl.2_Translation_Start_Site|IKBKAP_uc011lwc.1_Missense_Mutation_p.K174N|IKBKAP_uc010mtq.2_Translation_Start_Site	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	288					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						AGGCACTTACCTTAACCTCAT	0.328													24	91	---	---	---	---	PASS
TLR4	7099	broad.mit.edu	37	9	120476737	120476737	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr9:120476737C>T	uc004bjz.2	+	3	2622	c.2331C>T	c.(2329-2331)ACC>ACT	p.T777T	TLR4_uc004bka.2_Silent_p.T737T|TLR4_uc004bkb.2_Silent_p.T577T	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	777	Cytoplasmic (Potential).|TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TGGAGAAGACCCTGCTCAGGC	0.552													20	40	---	---	---	---	PASS
MORN5	254956	broad.mit.edu	37	9	124936896	124936896	+	Silent	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr9:124936896A>T	uc004blw.2	+	4	491	c.429A>T	c.(427-429)CTA>CTT	p.L143L	MORN5_uc011lyn.1_Silent_p.L143L|MORN5_uc011lyo.1_3'UTR	NM_198469	NP_940871	Q5VZ52	MORN5_HUMAN	MORN repeat containing 5	143											0						ACCGCTTTCTAAGAAACGCAG	0.458													38	74	---	---	---	---	PASS
MAPKAP1	79109	broad.mit.edu	37	9	128206877	128206877	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr9:128206877C>A	uc004bpv.2	-	11	1679	c.1346G>T	c.(1345-1347)AGT>ATT	p.S449I	MAPKAP1_uc011lzt.1_Missense_Mutation_p.S252I|MAPKAP1_uc010mwz.2_RNA|MAPKAP1_uc011lzu.1_Missense_Mutation_p.S252I|MAPKAP1_uc011lzv.1_Missense_Mutation_p.S157I|MAPKAP1_uc004bpw.2_Missense_Mutation_p.S257I|MAPKAP1_uc004bpx.2_Missense_Mutation_p.S257I|MAPKAP1_uc004bpy.2_Missense_Mutation_p.S413I|MAPKAP1_uc004bpz.2_Missense_Mutation_p.S402I|MAPKAP1_uc010mxa.2_RNA|MAPKAP1_uc004bpu.2_RNA	NM_001006617	NP_001006618	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated	449					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			ovary(2)|lung(2)	4						TATTGCGTGACCTGCAGAGAC	0.463													28	40	---	---	---	---	PASS
ZNF485	220992	broad.mit.edu	37	10	44104702	44104702	+	Splice_Site	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr10:44104702G>T	uc010qfc.1	+	4	346	c.152_splice	c.e4-1	p.G51_splice	ZNF485_uc010qfd.1_Intron	NM_145312	NP_660355	Q8NCK3	ZN485_HUMAN	zinc finger protein 485						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTTATGAACAGGGCTTCTCTC	0.463													14	35	---	---	---	---	PASS
OGDHL	55753	broad.mit.edu	37	10	50953543	50953543	+	Splice_Site	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr10:50953543C>A	uc001jie.2	-	12	1619	c.1477_splice	c.e12-1	p.V493_splice	OGDHL_uc009xog.2_Splice_Site_p.V520_splice|OGDHL_uc010qgt.1_Splice_Site_p.V436_splice|OGDHL_uc010qgu.1_Splice_Site_p.V284_splice|OGDHL_uc009xoh.2_Splice_Site_p.V284_splice	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a						glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GGTAACAGACCTGCAGGAGCA	0.587													12	86	---	---	---	---	PASS
OGDHL	55753	broad.mit.edu	37	10	50953930	50953930	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr10:50953930C>A	uc001jie.2	-	11	1532	c.1390G>T	c.(1390-1392)GCC>TCC	p.A464S	OGDHL_uc009xog.2_Missense_Mutation_p.A491S|OGDHL_uc010qgt.1_Missense_Mutation_p.A407S|OGDHL_uc010qgu.1_Missense_Mutation_p.A255S|OGDHL_uc009xoh.2_Missense_Mutation_p.A255S	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	464					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GGGTCATCGGCATTCACATGG	0.562													29	76	---	---	---	---	PASS
SGMS1	259230	broad.mit.edu	37	10	52087052	52087052	+	Missense_Mutation	SNP	T	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr10:52087052T>C	uc001jje.2	-	8	1608	c.654A>G	c.(652-654)ATA>ATG	p.I218M	SGMS1_uc010qhk.1_Missense_Mutation_p.I49M|SGMS1_uc009xot.1_RNA|SGMS1_uc010qhl.1_RNA	NM_147156	NP_671512	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	224	Helical; (Potential).				apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			ovary(1)|kidney(1)	2						GCGTGCCAACTATGCAGAAAA	0.378													14	45	---	---	---	---	PASS
ANK3	288	broad.mit.edu	37	10	61832138	61832138	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr10:61832138G>A	uc001jky.2	-	37	8693	c.8501C>T	c.(8500-8502)GCA>GTA	p.A2834V	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2834					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TATATGACATGCCAAGTCTTT	0.408													35	101	---	---	---	---	PASS
ANK3	288	broad.mit.edu	37	10	61832139	61832139	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr10:61832139C>A	uc001jky.2	-	37	8692	c.8500G>T	c.(8500-8502)GCA>TCA	p.A2834S	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2834					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						ATATGACATGCCAAGTCTTTA	0.408													35	102	---	---	---	---	PASS
RHOBTB1	9886	broad.mit.edu	37	10	62652698	62652698	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr10:62652698C>A	uc001jli.2	-	6	790	c.352G>T	c.(352-354)GTG>TTG	p.V118L	RHOBTB1_uc001jlh.2_Missense_Mutation_p.V118L|RHOBTB1_uc001jlj.2_Missense_Mutation_p.V118L|RHOBTB1_uc001jlk.2_Missense_Mutation_p.V118L|RHOBTB1_uc009xpe.1_Intron	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	118	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					ATGCTTTTCACATGATTTAGG	0.438													14	96	---	---	---	---	PASS
CTNNA3	29119	broad.mit.edu	37	10	68526159	68526159	+	Missense_Mutation	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr10:68526159T>A	uc009xpn.1	-	9	1267	c.1144A>T	c.(1144-1146)ATA>TTA	p.I382L	CTNNA3_uc001jmw.2_Missense_Mutation_p.I382L|CTNNA3_uc001jmx.3_Missense_Mutation_p.I382L	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	382					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						ACATGATCTATAATAGCCTTG	0.383													34	71	---	---	---	---	PASS
CDH23	64072	broad.mit.edu	37	10	73464789	73464789	+	Missense_Mutation	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr10:73464789A>T	uc001jrx.3	+	24	3232	c.2855A>T	c.(2854-2856)GAG>GTG	p.E952V	CDH23_uc001jry.2_Missense_Mutation_p.E568V|CDH23_uc001jrz.2_Missense_Mutation_p.E568V	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	952	Cadherin 9.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						ACCACCACCGAGCTGGACCGC	0.667													32	88	---	---	---	---	PASS
LIPK	643414	broad.mit.edu	37	10	90490874	90490874	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr10:90490874G>A	uc010qmv.1	+	3	358	c.358G>A	c.(358-360)GGA>AGA	p.G120R		NM_001080518	NP_001073987	Q5VXJ0	LIPK_HUMAN	lipase, family member K precursor	120					lipid catabolic process	extracellular region	hydrolase activity			ovary(2)	2		Colorectal(252;0.0381)		Colorectal(12;7.03e-05)|COAD - Colon adenocarcinoma(12;8.33e-05)		GAACAGCCGAGGAAACACTTG	0.438													3	21	---	---	---	---	PASS
PDCD11	22984	broad.mit.edu	37	10	105200258	105200258	+	Missense_Mutation	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr10:105200258A>T	uc001kwy.1	+	29	4447	c.4360A>T	c.(4360-4362)AGC>TGC	p.S1454C		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1454					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		ggagATGCCCAGCAAGGAGAA	0.363													5	29	---	---	---	---	PASS
PDZD8	118987	broad.mit.edu	37	10	119044590	119044590	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr10:119044590G>C	uc001lde.1	-	5	1853	c.1654C>G	c.(1654-1656)CTA>GTA	p.L552V		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	552	Pro-rich.				intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		TTCGGTGGTAGTGGGTGACTT	0.418													13	153	---	---	---	---	PASS
CPXM2	119587	broad.mit.edu	37	10	125506412	125506412	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr10:125506412C>G	uc001lhk.1	-	14	2464	c.2139G>C	c.(2137-2139)AGG>AGC	p.R713S	CPXM2_uc001lhj.2_Intron	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	713					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		TGAAGTCACACCTTGTGGCCC	0.552													30	186	---	---	---	---	PASS
SIGIRR	59307	broad.mit.edu	37	11	405988	405988	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:405988G>A	uc001lpd.2	-	10	1471	c.1141C>T	c.(1141-1143)CGG>TGG	p.R381W	SIGIRR_uc001lpf.2_Missense_Mutation_p.R381W|SIGIRR_uc001lpe.1_Missense_Mutation_p.R381W|SIGIRR_uc001lpg.2_Missense_Mutation_p.P477L	NM_001135054	NP_001128526	Q6IA17	SIGIR_HUMAN	single Ig IL-1R-related molecule	381	Cytoplasmic (Potential).				acute-phase response|innate immune response|negative regulation of chemokine biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity	integral to membrane	protein binding|transmembrane receptor activity				0		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCGCTGCTCCGGCTCTCTCCC	0.632													3	20	---	---	---	---	PASS
TRIM21	6737	broad.mit.edu	37	11	4407416	4407416	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:4407416C>T	uc001lyy.1	-	6	943	c.830G>A	c.(829-831)GGG>GAG	p.G277E		NM_003141	NP_003132	P19474	RO52_HUMAN	tripartite motif protein 21	277	B30.2/SPRY.				cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		CTTCTTCAGCCCTGGCACATG	0.542													13	51	---	---	---	---	PASS
OR52A4	390053	broad.mit.edu	37	11	5142212	5142212	+	Silent	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:5142212A>G	uc001lzz.1	-	1	597	c.597T>C	c.(595-597)ATT>ATC	p.I199I		NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AGACCTTATTAATGTAAACAT	0.388													11	55	---	---	---	---	PASS
PARVA	55742	broad.mit.edu	37	11	12540006	12540006	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:12540006C>T	uc001mki.2	+	12	1033	c.984C>T	c.(982-984)TCC>TCT	p.S328S		NM_018222	NP_060692	Q9NVD7	PARVA_HUMAN	parvin, alpha	328	CH 2.				cell adhesion|cell junction assembly|cilium morphogenesis	actin cytoskeleton|cytosol|focal adhesion	actin binding			breast(3)	3				Epithelial(150;0.00624)		TGAATGTCTCCTTTGCCTTTG	0.542													6	30	---	---	---	---	PASS
PIK3C2A	5286	broad.mit.edu	37	11	17141433	17141433	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:17141433C>A	uc001mmq.3	-	15	2812	c.2746G>T	c.(2746-2748)GCC>TCC	p.A916S	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Missense_Mutation_p.A536S|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	916					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity	p.A916T(1)		lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	CAGTTTGGGGCGCTTGCTAAT	0.363													24	62	---	---	---	---	PASS
ABCC8	6833	broad.mit.edu	37	11	17450120	17450120	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:17450120G>C	uc001mnc.2	-	13	2041	c.1915C>G	c.(1915-1917)CAG>GAG	p.Q639E		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	639	Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	ACCACCGCCTGGTACTTGCTG	0.607													14	45	---	---	---	---	PASS
RAG1	5896	broad.mit.edu	37	11	36596185	36596185	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:36596185C>T	uc001mwu.3	+	2	1455	c.1331C>T	c.(1330-1332)GCG>GTG	p.A444V	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	444	NBD.		A -> V (in OS/T(-)B(-)NK(+) SCID; atypical).		histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				GCTCTGAGGGCGAGGAATGAG	0.562									Familial_Hemophagocytic_Lymphohistiocytosis				9	68	---	---	---	---	PASS
TRIM48	79097	broad.mit.edu	37	11	55032733	55032733	+	Silent	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:55032733T>A	uc010rid.1	+	2	488	c.402T>A	c.(400-402)TCT>TCA	p.S134S		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	118	B box-type.					intracellular	zinc ion binding				0						GCTCCAGCTCTCAGGAGCACC	0.512													18	59	---	---	---	---	PASS
OR4C6	219432	broad.mit.edu	37	11	55433515	55433515	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:55433515G>T	uc001nht.3	+	3	1138	c.873G>T	c.(871-873)GAG>GAT	p.E291D	OR4C6_uc010rik.1_Missense_Mutation_p.E291D	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	291	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GGAATGCAGAGGTGAAAAGTG	0.458													14	44	---	---	---	---	PASS
OR5W2	390148	broad.mit.edu	37	11	55681351	55681351	+	Missense_Mutation	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:55681351T>A	uc010rir.1	-	1	708	c.708A>T	c.(706-708)AAA>AAT	p.K236N		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TAGAGAGAGCTTTGAACCTCC	0.408													16	55	---	---	---	---	PASS
OR8K1	390157	broad.mit.edu	37	11	56113545	56113545	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:56113545G>T	uc010rjg.1	+	1	31	c.31G>T	c.(31-33)GCA>TCA	p.A11S		NM_001002907	NP_001002907	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					CAATCACACGGCAGTGACCAA	0.378										HNSCC(65;0.19)			10	61	---	---	---	---	PASS
MARK2	2011	broad.mit.edu	37	11	63672277	63672277	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:63672277C>T	uc001nxw.2	+	16	2275	c.1696C>T	c.(1696-1698)CCT>TCT	p.P566S	MARK2_uc001nxx.2_Missense_Mutation_p.P512S|MARK2_uc001nxy.2_Missense_Mutation_p.P511S|MARK2_uc001nxv.3_Missense_Mutation_p.P511S|MARK2_uc001nxz.3_Missense_Mutation_p.P532S|MARK2_uc009yoy.2_Missense_Mutation_p.P486S	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	566					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CCAGCGTGTCCCTGTTGCCTC	0.627													14	59	---	---	---	---	PASS
SNX32	254122	broad.mit.edu	37	11	65620199	65620199	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:65620199C>T	uc001ofr.2	+	11	1138	c.1011C>T	c.(1009-1011)GCC>GCT	p.A337A		NM_152760	NP_689973	Q86XE0	SNX32_HUMAN	sorting nexin 6B	337					cell communication|protein transport		phosphatidylinositol binding				0				READ - Rectum adenocarcinoma(159;0.171)		TGCGGCCCGCCGAGAGCCACC	0.701													4	19	---	---	---	---	PASS
PCF11	51585	broad.mit.edu	37	11	82868499	82868499	+	Silent	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:82868499G>T	uc001ozx.3	+	1	363	c.18G>T	c.(16-18)CCG>CCT	p.P6P	PCF11_uc010rsu.1_Silent_p.P6P|PCF11_uc001ozy.2_Silent_p.P6P	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	6					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						AGCAGACGCCGGCCGAGGCCG	0.652													23	58	---	---	---	---	PASS
FAT3	120114	broad.mit.edu	37	11	92616492	92616492	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:92616492C>T	uc001pdj.3	+	23	12887	c.12870C>T	c.(12868-12870)CCC>CCT	p.P4290P	FAT3_uc001pdi.3_Silent_p.P730P	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4290	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCAACCTCCCCGCCGTGTCAC	0.652										TCGA Ovarian(4;0.039)			10	23	---	---	---	---	PASS
EXPH5	23086	broad.mit.edu	37	11	108381393	108381393	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:108381393C>T	uc001pkk.2	-	6	4952	c.4841G>A	c.(4840-4842)AGA>AAA	p.R1614K	EXPH5_uc010rvy.1_Missense_Mutation_p.R1426K|EXPH5_uc010rvz.1_Missense_Mutation_p.R1458K|EXPH5_uc010rwa.1_Missense_Mutation_p.R1538K	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1614					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		AGCTACATGTCTTCTGGGGCT	0.463													12	137	---	---	---	---	PASS
MLL	4297	broad.mit.edu	37	11	118374454	118374454	+	Missense_Mutation	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:118374454A>G	uc001pta.2	+	27	7861	c.7838A>G	c.(7837-7839)AAA>AGA	p.K2613R	MLL_uc001ptb.2_Missense_Mutation_p.K2616R	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2613					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GGCTCTTTTAAAAGGAGGTAT	0.468			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								14	33	---	---	---	---	PASS
FEZ1	9638	broad.mit.edu	37	11	125359548	125359548	+	Silent	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:125359548G>T	uc001qbx.2	-	2	278	c.126C>A	c.(124-126)TCC>TCA	p.S42S	FEZ1_uc010sbc.1_Silent_p.S42S|FEZ1_uc001qby.1_Silent_p.S42S	NM_005103	NP_005094	Q99689	FEZ1_HUMAN	zygin 1 isoform 1	42					axon guidance|cell adhesion|transport	microtubule|plasma membrane				central_nervous_system(3)|ovary(1)	4	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0934)		GCTCGGAGAGGGAGGGGTCCT	0.502													19	93	---	---	---	---	PASS
B3GAT1	27087	broad.mit.edu	37	11	134254047	134254047	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:134254047C>T	uc001qhq.2	-	4	409	c.148G>A	c.(148-150)GGC>AGC	p.G50S	B3GAT1_uc001qhr.2_Missense_Mutation_p.G50S|B3GAT1_uc010scv.1_Missense_Mutation_p.G63S	NM_018644	NP_061114	Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1	50	Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)		GGGTCGGCGCCGGGCGGCGTT	0.701													8	21	---	---	---	---	PASS
ERC1	23085	broad.mit.edu	37	12	1137166	1137166	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:1137166C>T	uc001qjb.2	+	2	338	c.97C>T	c.(97-99)CGT>TGT	p.R33C	ERC1_uc001qiz.2_RNA|ERC1_uc001qjc.2_Missense_Mutation_p.R33C|ERC1_uc001qja.2_RNA|ERC1_uc001qjd.2_RNA|ERC1_uc001qjf.2_Missense_Mutation_p.R33C	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	33					I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			CTTGGGTCACCGTCGAACCAA	0.552													33	123	---	---	---	---	PASS
CACNA2D4	93589	broad.mit.edu	37	12	2027512	2027512	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:2027512G>T	uc001qjp.2	-	1	359	c.128C>A	c.(127-129)GCC>GAC	p.A43D	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Missense_Mutation_p.A43D	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	43	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		AAAGGCCCAGGCCACGGGCAT	0.652													10	11	---	---	---	---	PASS
CD27	939	broad.mit.edu	37	12	6560174	6560174	+	Nonsense_Mutation	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:6560174A>T	uc001qod.2	+	5	863	c.652A>T	c.(652-654)AGA>TGA	p.R218*	LOC678655_uc001qob.2_Intron|LOC678655_uc001qoc.2_Intron|LOC678655_uc009zel.1_RNA|CD27_uc001qoe.2_Nonsense_Mutation_p.R68*|LOC678655_uc009zem.1_Intron|LOC678655_uc001qof.2_Intron|TAPBPL_uc001qog.3_5'Flank|TAPBPL_uc001qoh.3_5'Flank|TAPBPL_uc001qoi.1_5'Flank	NM_001242	NP_001233	P26842	CD27_HUMAN	tumor necrosis factor receptor superfamily,	218	Cytoplasmic (Potential).				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity				0						AAGGAAATATAGATCAAGTAA	0.542													9	144	---	---	---	---	PASS
PLCZ1	89869	broad.mit.edu	37	12	18854646	18854646	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:18854646C>A	uc010sid.1	-	8	1120	c.929G>T	c.(928-930)AGA>ATA	p.R310I	PLCZ1_uc001rdv.3_Missense_Mutation_p.R206I|PLCZ1_uc001rdw.3_Missense_Mutation_p.R51I|PLCZ1_uc001rdu.1_Missense_Mutation_p.R51I|PLCZ1_uc009zil.1_RNA	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	310					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					AGAACCTTTTCTTTCATGGGT	0.269													10	19	---	---	---	---	PASS
GYS2	2998	broad.mit.edu	37	12	21711179	21711179	+	Silent	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:21711179G>A	uc001rfb.2	-	11	1632	c.1377C>T	c.(1375-1377)ACC>ACT	p.T459T		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	459					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						TCCGTCTAATGGTGCTGAGGA	0.428													16	76	---	---	---	---	PASS
ETNK1	55500	broad.mit.edu	37	12	22812020	22812020	+	Silent	SNP	T	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:22812020T>G	uc001rft.2	+	3	778	c.756T>G	c.(754-756)CTT>CTG	p.L252L	ETNK1_uc009ziz.2_Silent_p.L252L	NM_018638	NP_061108	Q9HBU6	EKI1_HUMAN	ethanolamine kinase 1 isoform A	252				RLIARQLAKIHAIHAHNGWIPKSNLWLKMGK -> SLSSLT LCKGKTTRCFGLTGCRGSRLLLSFF (in Ref. 2; AAH06111).	phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity				0						AATCTAATCTTTGGCTAAAGA	0.338													16	69	---	---	---	---	PASS
KRAS	3845	broad.mit.edu	37	12	25380275	25380275	+	Missense_Mutation	SNP	T	A	A	rs17851045		TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:25380275T>A	uc001rgp.1	-	3	364	c.183A>T	c.(181-183)CAA>CAT	p.Q61H	KRAS_uc001rgq.1_Missense_Mutation_p.Q61H	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	61	GTP.		Q -> R (in a colorectal cancer sample; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.Q61H(140)|p.Q61L(51)|p.Q61R(44)|p.Q61K(24)|p.Q61P(11)|p.Q61E(10)|p.Q61D(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			TGTACTCCTCTTGACCTGCTG	0.423	Q61H(T3M4_PANCREAS)|Q61H(HS766T_PANCREAS)|Q61H(NCIH460_LUNG)|Q61H(NCIH1155_LUNG)|Q61H(CL11_LARGE_INTESTINE)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			31	44	---	---	---	---	PASS
KIF21A	55605	broad.mit.edu	37	12	39735383	39735383	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:39735383C>A	uc001rly.2	-	14	1991	c.1845G>T	c.(1843-1845)GAG>GAT	p.E615D	KIF21A_uc001rlw.2_5'Flank|KIF21A_uc001rlx.2_Missense_Mutation_p.E602D|KIF21A_uc001rlz.2_Missense_Mutation_p.E602D|KIF21A_uc010skl.1_Missense_Mutation_p.E602D	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	615					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				cctcctcctcctcttcttcat	0.303													10	32	---	---	---	---	PASS
SLC2A13	114134	broad.mit.edu	37	12	40441918	40441918	+	Silent	SNP	T	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:40441918T>C	uc010skm.1	-	2	702	c.651A>G	c.(649-651)ACA>ACG	p.T217T	SLC2A13_uc001rmf.2_Silent_p.T217T	NM_052885	NP_443117	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose	217	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			ovary(1)	1		Lung NSC(34;0.105)|all_lung(34;0.123)				ACTGCCCTCCTGTGATGAAGA	0.408										HNSCC(50;0.14)			42	154	---	---	---	---	PASS
MLL2	8085	broad.mit.edu	37	12	49431525	49431525	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:49431525C>A	uc001rta.3	-	34	9614	c.9614G>T	c.(9613-9615)GGA>GTA	p.G3205V		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3205					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGAGGATCCTCCTGGGCCACT	0.602			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			3	5	---	---	---	---	PASS
NCKAP5L	57701	broad.mit.edu	37	12	50185658	50185658	+	Silent	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:50185658G>C	uc009zlk.2	-	13	4171	c.3969C>G	c.(3967-3969)CTC>CTG	p.L1323L	NCKAP5L_uc001rvc.3_Silent_p.L527L|NCKAP5L_uc001rvb.2_3'UTR	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	1319										central_nervous_system(1)	1						GCGAGTCGTAGAGTGAGTCAC	0.677													4	26	---	---	---	---	PASS
KRT71	112802	broad.mit.edu	37	12	52942093	52942093	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:52942093G>T	uc001sao.2	-	5	891	c.821C>A	c.(820-822)ACT>AAT	p.T274N		NM_033448	NP_258259	Q3SY84	K2C71_HUMAN	keratin 71	274	Coil 1B.|Rod.						structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.194)		CTGGATCTGAGTGATCTCCTG	0.532													31	54	---	---	---	---	PASS
STAT6	6778	broad.mit.edu	37	12	57492632	57492632	+	Missense_Mutation	SNP	T	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:57492632T>C	uc009zpe.2	-	18	2260	c.2009A>G	c.(2008-2010)TAT>TGT	p.Y670C	STAT6_uc009zpf.2_Missense_Mutation_p.Y670C|STAT6_uc001sna.2_Missense_Mutation_p.Y670C|STAT6_uc010srb.1_Missense_Mutation_p.Y560C|STAT6_uc010src.1_Missense_Mutation_p.Y560C|STAT6_uc010srd.1_Missense_Mutation_p.Y560C|STAT6_uc009zpg.2_Missense_Mutation_p.Y719C	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	670					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4						TCCAAGGTCATAAGAAGGCAC	0.542													43	154	---	---	---	---	PASS
CAND1	55832	broad.mit.edu	37	12	67706425	67706425	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:67706425G>A	uc001stn.2	+	15	3945	c.3508G>A	c.(3508-3510)GAT>AAT	p.D1170N	CAND1_uc001sto.2_Missense_Mutation_p.D680N	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	1170	HEAT 27.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TGAAAAACAAGATGAATTAAA	0.398													14	17	---	---	---	---	PASS
NAV3	89795	broad.mit.edu	37	12	78225481	78225481	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:78225481C>G	uc001syp.2	+	1	413	c.240C>G	c.(238-240)AGC>AGG	p.S80R	NAV3_uc001syo.2_Missense_Mutation_p.S80R	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	80	CH.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AAGAAGACAGCAAGGTTAGTT	0.413										HNSCC(70;0.22)			16	21	---	---	---	---	PASS
C12orf12	196477	broad.mit.edu	37	12	91348137	91348137	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:91348137G>C	uc001tbj.2	-	1	817	c.383C>G	c.(382-384)TCC>TGC	p.S128C		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	128										central_nervous_system(1)|pancreas(1)	2						AGGGTTCCAGGACCCGCTCCA	0.677													3	33	---	---	---	---	PASS
MYO1H	283446	broad.mit.edu	37	12	109834222	109834222	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:109834222G>T	uc010sxn.1	+	3	276	c.276G>T	c.(274-276)ATG>ATT	p.M92I		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	Error:Variant_position_missing_in_B4DNW6_after_alignment						myosin complex	motor activity				0						ACCGAATGATGTGTGCTGAAC	0.463													11	41	---	---	---	---	PASS
MVK	4598	broad.mit.edu	37	12	110019347	110019347	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:110019347C>T	uc001toy.3	+	5	703	c.519C>T	c.(517-519)TGC>TGT	p.C173C	MVK_uc009zvk.2_Silent_p.C173C|MVK_uc010sxr.1_Intron|MVK_uc001toz.3_Intron|MVK_uc001tpc.3_RNA	NM_001114185	NP_001107657	Q03426	KIME_HUMAN	mevalonate kinase	173					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|peroxisome	ATP binding|identical protein binding|mevalonate kinase activity				0						ACGGGGATTGCGTCAACAGGT	0.522													8	39	---	---	---	---	PASS
SRRM4	84530	broad.mit.edu	37	12	119583443	119583443	+	Silent	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:119583443G>C	uc001txa.1	+	9	1321	c.1029G>C	c.(1027-1029)GGG>GGC	p.G343G		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	343	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						AGAACAAGGGGGCCATGTTGG	0.617													6	16	---	---	---	---	PASS
PIWIL1	9271	broad.mit.edu	37	12	130845880	130845880	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr12:130845880G>T	uc001uik.2	+	15	1911	c.1821G>T	c.(1819-1821)CAG>CAT	p.Q607H	PIWIL1_uc001uij.1_Missense_Mutation_p.Q607H	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	607	RNA-binding (By similarity).|Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		TTGCCCTACAGATGAACTGCA	0.473													40	59	---	---	---	---	PASS
SACS	26278	broad.mit.edu	37	13	23905162	23905162	+	Missense_Mutation	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr13:23905162T>A	uc001uon.2	-	10	13442	c.12853A>T	c.(12853-12855)AGC>TGC	p.S4285C	SACS_uc001uoo.2_Missense_Mutation_p.S4138C|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4285					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GTCTTGTGGCTCTCTCTACCA	0.478													24	76	---	---	---	---	PASS
AKAP11	11215	broad.mit.edu	37	13	42874720	42874720	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr13:42874720G>T	uc001uys.1	+	8	2013	c.1838G>T	c.(1837-1839)AGT>ATT	p.S613I		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	613					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		CGTGCCATTAGTGGCCTGGCT	0.388													12	54	---	---	---	---	PASS
CYSLTR2	57105	broad.mit.edu	37	13	49281661	49281661	+	Silent	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr13:49281661G>T	uc010acx.1	+	6	1391	c.708G>T	c.(706-708)TCG>TCT	p.S236S	CYSLTR2_uc010acy.1_Silent_p.S236S|CYSLTR2_uc010acz.1_Silent_p.S236S|CYSLTR2_uc010ada.1_Silent_p.S236S|CYSLTR2_uc010adb.1_Silent_p.S236S|CYSLTR2_uc010adc.1_Silent_p.S236S|CYSLTR2_uc010add.1_Silent_p.S236S|CYSLTR2_uc010acw.1_Silent_p.S236S|CYSLTR2_uc001vck.2_Silent_p.S236S	NM_020377	NP_065110	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	236	Cytoplasmic (Potential).				immune response	integral to membrane|plasma membrane				lung(2)	2		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	TCCCAGAATCGGGGCTGCGGG	0.507													31	79	---	---	---	---	PASS
KLHL1	57626	broad.mit.edu	37	13	70314552	70314552	+	Silent	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr13:70314552T>A	uc001vip.2	-	8	2570	c.1776A>T	c.(1774-1776)ACA>ACT	p.T592T	KLHL1_uc010thm.1_Silent_p.T531T	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	592	Kelch 3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CTACACCAACTGTGCTCCGAG	0.358													11	32	---	---	---	---	PASS
SCEL	8796	broad.mit.edu	37	13	78208526	78208526	+	Silent	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr13:78208526A>T	uc001vki.2	+	29	1874	c.1704A>T	c.(1702-1704)GGA>GGT	p.G568G	SCEL_uc001vkj.2_Silent_p.G548G|SCEL_uc010thx.1_Silent_p.G526G	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	568					embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		CTAACACTGGAGCCAAGCAGG	0.313													7	23	---	---	---	---	PASS
SOS2	6655	broad.mit.edu	37	14	50585439	50585439	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr14:50585439G>T	uc001wxs.3	-	23	3720	c.3622C>A	c.(3622-3624)CCA>ACA	p.P1208T	SOS2_uc010ans.2_Missense_Mutation_p.P43T|SOS2_uc010tql.1_Missense_Mutation_p.P1175T|C14orf138_uc001wxn.1_5'Flank|C14orf138_uc001wxo.1_5'Flank|C14orf138_uc001wxp.1_5'Flank|C14orf138_uc001wxq.1_5'Flank	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	1208	Poly-Pro.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					GGATCTCTTGGTGGTGGCGGA	0.527													28	155	---	---	---	---	PASS
NIN	51199	broad.mit.edu	37	14	51190286	51190286	+	Silent	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr14:51190286T>A	uc001wyi.2	-	31	6488	c.6297A>T	c.(6295-6297)GCA>GCT	p.A2099A	NIN_uc001wyj.2_RNA	NM_020921	NP_065972	Q8N4C6	NIN_HUMAN	ninein isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					TTTTCTTCTCTGCTGTTTTCT	0.453			T	PDGFRB	MPD								11	89	---	---	---	---	PASS
RTN1	6252	broad.mit.edu	37	14	60069953	60069953	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr14:60069953G>A	uc001xen.1	-	7	2415	c.2206C>T	c.(2206-2208)CCT>TCT	p.P736S	RTN1_uc001xem.1_Missense_Mutation_p.P316S|RTN1_uc001xek.1_Missense_Mutation_p.P168S|RTN1_uc001xel.1_RNA|RTN1_uc010apl.1_Missense_Mutation_p.P153S	NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	736	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		TACACTACAGGTAGAGTAAAC	0.303													7	44	---	---	---	---	PASS
SIX4	51804	broad.mit.edu	37	14	61180336	61180336	+	Missense_Mutation	SNP	C	A	A	rs112624131	byFrequency	TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr14:61180336C>A	uc001xfc.2	-	3	2135	c.2135G>T	c.(2134-2136)CGT>CTT	p.R712L		NM_017420	NP_059116	Q9UIU6	SIX4_HUMAN	sine oculis homeobox homolog 4	712						nucleus				breast(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		CAGAACCAAACGATGTTCTTG	0.443													11	46	---	---	---	---	PASS
C14orf181	400223	broad.mit.edu	37	14	69262628	69262628	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr14:69262628C>T	uc001xkj.1	-	1	563	c.384G>A	c.(382-384)GAG>GAA	p.E128E	ZFP36L1_uc001xkh.1_5'Flank|ZFP36L1_uc001xki.1_5'Flank	NM_207442	NP_997325			hypothetical protein LOC400223												0				all cancers(60;0.002)|BRCA - Breast invasive adenocarcinoma(234;0.00204)|OV - Ovarian serous cystadenocarcinoma(108;0.0399)		CCGACCCGCCCTCGCCCAGAC	0.751													3	26	---	---	---	---	PASS
SLC8A3	6547	broad.mit.edu	37	14	70517727	70517727	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr14:70517727G>T	uc001xly.2	-	6	2883	c.2129C>A	c.(2128-2130)GCA>GAA	p.A710E	SLC8A3_uc001xlu.2_Missense_Mutation_p.A67E|SLC8A3_uc001xlv.2_Missense_Mutation_p.A81E|SLC8A3_uc001xlw.2_Missense_Mutation_p.A707E|SLC8A3_uc001xlx.2_Missense_Mutation_p.A708E|SLC8A3_uc001xlz.2_Missense_Mutation_p.A704E|SLC8A3_uc010ara.2_RNA|SLC8A3_uc001xma.2_Missense_Mutation_p.A67E	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	710	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CTTCTCACCTGCACTGACGGT	0.562													7	44	---	---	---	---	PASS
FAM161B	145483	broad.mit.edu	37	14	74409390	74409390	+	Silent	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr14:74409390G>A	uc001xpd.1	-	4	1060	c.954C>T	c.(952-954)ATC>ATT	p.I318I		NM_152445	NP_689658			hypothetical protein LOC145483											ovary(1)	1						CTCTCATTTGGATGCGAATTT	0.547													9	65	---	---	---	---	PASS
LTBP2	4053	broad.mit.edu	37	14	75017963	75017963	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr14:75017963C>A	uc001xqa.2	-	7	1877	c.1490G>T	c.(1489-1491)GGG>GTG	p.G497V		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	497					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CTCCTCCACCCCGCCCCGCAC	0.677													10	24	---	---	---	---	PASS
DIO2	1734	broad.mit.edu	37	14	80677628	80677628	+	Missense_Mutation	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr14:80677628A>T	uc010tvq.1	-	2	590	c.188T>A	c.(187-189)GTC>GAC	p.V63D	uc001xuw.1_5'Flank|DIO2_uc010tvp.1_Missense_Mutation_p.V63D|DIO2_uc001xut.2_RNA|DIO2_uc010asx.2_Missense_Mutation_p.V63D|DIO2_uc010tvr.1_Missense_Mutation_p.V63D|DIO2_uc010asy.2_Missense_Mutation_p.V63D	NM_000793	NP_000784	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II isoform a	63					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0281)		GCTCTTCCAGACGCAGCGCAG	0.607													5	24	---	---	---	---	PASS
FOXN3	1112	broad.mit.edu	37	14	89656795	89656795	+	Splice_Site	SNP	T	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr14:89656795T>C	uc001xxo.3	-	5	883	c.746_splice	c.e5-1	p.D249_splice	FOXN3_uc001xxn.3_Intron|FOXN3_uc010atk.2_Intron	NM_001085471	NP_001078940	O00409	FOXN3_HUMAN	checkpoint suppressor 1 isoform 1						DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(2)|ovary(1)	3						TGTCAGGATCTGGAAAAATCA	0.413													4	19	---	---	---	---	PASS
ATG2B	55102	broad.mit.edu	37	14	96779691	96779691	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr14:96779691G>A	uc001yfi.2	-	24	4089	c.3724C>T	c.(3724-3726)CTT>TTT	p.L1242F		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1242										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		CAGCTCCAAAGATGAACATGA	0.264													11	47	---	---	---	---	PASS
OR4M2	390538	broad.mit.edu	37	15	22368679	22368679	+	Missense_Mutation	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:22368679A>G	uc010tzu.1	+	1	104	c.104A>G	c.(103-105)TAT>TGT	p.Y35C	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTATCCTTCTATTTGTTCATC	0.418													24	343	---	---	---	---	PASS
GOLGA8E	390535	broad.mit.edu	37	15	23444021	23444021	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:23444021C>A	uc001yvu.2	+	14	1665	c.676C>A	c.(676-678)CAT>AAT	p.H226N		NM_001012423	NP_001012423			golgi autoantigen, golgin subfamily a, 8E											skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;5.21e-07)|Epithelial(43;5.65e-06)|BRCA - Breast invasive adenocarcinoma(123;0.000614)		CGGAGGAGAACATCTGGACAG	0.617													4	82	---	---	---	---	PASS
C15orf2	23742	broad.mit.edu	37	15	24921383	24921383	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:24921383C>G	uc001ywo.2	+	1	843	c.369C>G	c.(367-369)TTC>TTG	p.F123L		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	123					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GCCGCATGTTCACTCTCCTGC	0.652													10	40	---	---	---	---	PASS
GABRG3	2567	broad.mit.edu	37	15	27573988	27573988	+	Missense_Mutation	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:27573988A>T	uc001zbg.1	+	5	693	c.527A>T	c.(526-528)CAC>CTC	p.H176L	GABRG3_uc001zbf.2_Missense_Mutation_p.H176L	NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	176	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		CTGCAGCTGCACAACTTCCCC	0.592													9	40	---	---	---	---	PASS
RYR3	6263	broad.mit.edu	37	15	33922197	33922197	+	Silent	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:33922197A>T	uc001zhi.2	+	22	2806	c.2736A>T	c.(2734-2736)CCA>CCT	p.P912P	RYR3_uc010bar.2_Silent_p.P912P	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	912	4 X approximate repeats.|1.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAAAGCTCCCAGAAACTGAGA	0.348													6	17	---	---	---	---	PASS
RYR3	6263	broad.mit.edu	37	15	34064229	34064229	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:34064229G>T	uc001zhi.2	+	63	8995	c.8925G>T	c.(8923-8925)AAG>AAT	p.K2975N	RYR3_uc010bar.2_Missense_Mutation_p.K2975N	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2975	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AACTTGGGAAGTTCACCCATT	0.468													9	30	---	---	---	---	PASS
RPAP1	26015	broad.mit.edu	37	15	41827134	41827134	+	Splice_Site	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:41827134C>T	uc001zod.2	-	6	666	c.542_splice	c.e6-1	p.G181_splice		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1							nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GTCACGGCACCTGGAAGAAAG	0.542													7	47	---	---	---	---	PASS
MYO5A	4644	broad.mit.edu	37	15	52620125	52620125	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:52620125G>A	uc002aby.2	-	35	4803	c.4559C>T	c.(4558-4560)GCT>GTT	p.A1520V	MYO5A_uc002abx.3_Missense_Mutation_p.A1493V|MYO5A_uc010ugd.1_Missense_Mutation_p.A242V	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1520					actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CAGGTAGTCAGCATGTCGAAC	0.358													40	172	---	---	---	---	PASS
MYO5A	4644	broad.mit.edu	37	15	52659297	52659297	+	Missense_Mutation	SNP	T	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:52659297T>G	uc002aby.2	-	23	3335	c.3091A>C	c.(3091-3093)AAT>CAT	p.N1031H	MYO5A_uc002abx.3_Missense_Mutation_p.N1031H|MYO5A_uc010uge.1_Missense_Mutation_p.N900H	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1031	Potential.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		AGCAAAGTATTTTCTTCCTTC	0.433													14	53	---	---	---	---	PASS
ZNF280D	54816	broad.mit.edu	37	15	56981257	56981257	+	Silent	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:56981257A>G	uc002adu.2	-	9	979	c.762T>C	c.(760-762)CCT>CCC	p.P254P	ZNF280D_uc002adv.2_Silent_p.P241P|ZNF280D_uc010bfq.2_Silent_p.P254P|ZNF280D_uc002adw.1_Silent_p.P282P|ZNF280D_uc010bfr.1_RNA	NM_017661	NP_060131	Q6N043	Z280D_HUMAN	suppressor of hairy wing homolog 4 isoform 1	254					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		GATTTTTCAAAGGATCCAAAA	0.289													14	66	---	---	---	---	PASS
NARG2	79664	broad.mit.edu	37	15	60715913	60715913	+	Missense_Mutation	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:60715913T>A	uc002agp.2	-	16	3104	c.2869A>T	c.(2869-2871)ATG>TTG	p.M957L	NARG2_uc002ago.2_Missense_Mutation_p.M820L	NM_024611	NP_078887	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2 isoform a	957						nucleus				ovary(1)|lung(1)	2						TTGGTTTCCATGGAAACTGGA	0.423													7	47	---	---	---	---	PASS
HERC1	8925	broad.mit.edu	37	15	63904582	63904582	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:63904582C>G	uc002amp.2	-	77	14416	c.14268G>C	c.(14266-14268)TGG>TGC	p.W4756C	HERC1_uc002amo.2_5'Flank	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	4756	HECT.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TGTGCCAGAACCACTGCACCA	0.532													19	57	---	---	---	---	PASS
ITGA11	22801	broad.mit.edu	37	15	68624760	68624760	+	Silent	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:68624760C>A	uc002ari.2	-	13	1569	c.1482G>T	c.(1480-1482)GTG>GTT	p.V494V	ITGA11_uc010bib.2_Silent_p.V494V	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	494	FG-GAP 5.|Potential.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	GGACATCAGTCACGCCGTCGC	0.607													7	13	---	---	---	---	PASS
NOX5	79400	broad.mit.edu	37	15	69328164	69328164	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:69328164G>T	uc002ars.1	+	7	1096	c.1076G>T	c.(1075-1077)GGC>GTC	p.G359V	NOX5_uc002arp.1_Missense_Mutation_p.G341V|NOX5_uc002arq.1_Missense_Mutation_p.G313V|NOX5_uc010bid.1_Missense_Mutation_p.G324V|NOX5_uc002arr.1_Missense_Mutation_p.G331V|NOX5_uc010bie.1_Missense_Mutation_p.G159V|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	359	Extracellular (Potential).|Ferric oxidoreductase.				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						ACGAGGCCTGGCATTGGCTGG	0.602													26	103	---	---	---	---	PASS
LOXL1	4016	broad.mit.edu	37	15	74239501	74239501	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:74239501C>T	uc002awc.1	+	4	1779	c.1443C>T	c.(1441-1443)TGC>TGT	p.C481C	LOXL1_uc002awd.1_5'Flank	NM_005576	NP_005567	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1 preproprotein	481	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding				0						CCAGTTTCTGCCTGGAGGACA	0.592													9	65	---	---	---	---	PASS
CHRNB4	1143	broad.mit.edu	37	15	78923422	78923422	+	Missense_Mutation	SNP	T	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:78923422T>G	uc002bed.1	-	4	467	c.355A>C	c.(355-357)AAC>CAC	p.N119H	CHRNB4_uc002bee.1_Missense_Mutation_p.N119H|CHRNB4_uc010blh.1_5'UTR	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	119	Extracellular (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						ACTCACTTGTTGTAAAGCACG	0.602													14	47	---	---	---	---	PASS
EFTUD1	79631	broad.mit.edu	37	15	82507156	82507156	+	Missense_Mutation	SNP	T	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr15:82507156T>C	uc002bgt.1	-	15	1821	c.1652A>G	c.(1651-1653)CAA>CGA	p.Q551R	EFTUD1_uc002bgu.1_Missense_Mutation_p.Q500R	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	551					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						GTGGGGGACTTGGGGGAGGCC	0.478													15	54	---	---	---	---	PASS
MRPL28	10573	broad.mit.edu	37	16	419061	419061	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr16:419061C>T	uc002cgr.1	-	2	464	c.448G>A	c.(448-450)GGG>AGG	p.G150R	MRPL28_uc010bqu.1_Missense_Mutation_p.G150R|MRPL28_uc002cgs.1_Intron|MRPL28_uc002cgt.1_Missense_Mutation_p.G150R	NM_006428	NP_006419	Q13084	RM28_HUMAN	mitochondrial ribosomal protein L28 precursor	150				TPK -> ASG (in Ref. 4).	translation	mitochondrial ribosome	protein binding|structural constituent of ribosome				0		Hepatocellular(16;0.000105)|Lung NSC(18;0.0324)|all_lung(18;0.064)				CGCCCCACCCCGCTTGCCTTG	0.592													5	32	---	---	---	---	PASS
PAQR4	124222	broad.mit.edu	37	16	3021660	3021660	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr16:3021660G>A	uc002csj.3	+	3	867	c.533G>A	c.(532-534)GGA>GAA	p.G178E	PAQR4_uc002csk.3_Missense_Mutation_p.G139E|PAQR4_uc002csl.3_Missense_Mutation_p.G104E|PAQR4_uc010uwm.1_Missense_Mutation_p.G109E	NM_152341	NP_689554	Q8N4S7	PAQR4_HUMAN	progestin and adipoQ receptor family member IV	178						integral to membrane	receptor activity				0						CGGGCATTTGGATGGCAGGCT	0.697													19	71	---	---	---	---	PASS
UMOD	7369	broad.mit.edu	37	16	20357448	20357448	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr16:20357448C>T	uc002dgz.2	-	5	1311	c.1182G>A	c.(1180-1182)ACG>ACA	p.T394T	UMOD_uc002dha.2_Silent_p.T394T|UMOD_uc002dhb.2_Silent_p.T427T	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	394	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						CAGGACGTACCGTCAACACTG	0.393													9	33	---	---	---	---	PASS
NECAB2	54550	broad.mit.edu	37	16	84014678	84014678	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr16:84014678C>T	uc002fhd.2	+	5	422	c.405C>T	c.(403-405)GCC>GCT	p.A135A	NECAB2_uc002fhe.2_Silent_p.A52A	NM_019065	NP_061938	Q7Z6G3	NECA2_HUMAN	neuronal calcium-binding protein 2	135					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity|protein binding			ovary(2)	2						ATGTCCTGGCCTCCCTGGAGA	0.587													68	102	---	---	---	---	PASS
ACSF3	197322	broad.mit.edu	37	16	89187245	89187245	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr16:89187245G>C	uc002fmp.2	+	7	1503	c.1163G>C	c.(1162-1164)CGC>CCC	p.R388P	ACSF3_uc010cig.1_Missense_Mutation_p.R388P|ACSF3_uc010cih.1_Missense_Mutation_p.R123P|ACSF3_uc002fmq.1_RNA|ACSF3_uc010cii.1_RNA|ACSF3_uc002fmr.1_Missense_Mutation_p.R123P	NM_174917	NP_777577	Q4G176	ACSF3_HUMAN	acyl-CoA synthetase family member 3 precursor	388					fatty acid metabolic process	mitochondrion	acid-thiol ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0281)		GTACAGGTGCGCATTGTCTCA	0.592													35	123	---	---	---	---	PASS
SGSM2	9905	broad.mit.edu	37	17	2266300	2266300	+	Nonsense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr17:2266300G>T	uc002fun.3	+	6	719	c.544G>T	c.(544-546)GAA>TAA	p.E182*	SGSM2_uc002fum.3_Nonsense_Mutation_p.E182*|SGSM2_uc010vqw.1_Nonsense_Mutation_p.E182*	NM_001098509	NP_001091979	O43147	SGSM2_HUMAN	RUN and TBC1 domain containing 1 isoform 2	182	RUN.					intracellular	Rab GTPase activator activity				0				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		CTGTGCCTTGGAATACACTAA	0.617													14	73	---	---	---	---	PASS
ALOX15	246	broad.mit.edu	37	17	4535513	4535513	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr17:4535513G>T	uc002fyh.2	-	12	1618	c.1604C>A	c.(1603-1605)ACC>AAC	p.T535N	ALOX15_uc010vsd.1_Missense_Mutation_p.T496N|ALOX15_uc010vse.1_Missense_Mutation_p.T557N	NM_001140	NP_001131	P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	535	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			skin(3)|ovary(1)|lung(1)	5				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	GCCGGTGCAGGTGAAGATACA	0.572													5	48	---	---	---	---	PASS
TP53	7157	broad.mit.edu	37	17	7578457	7578457	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr17:7578457C>A	uc002gim.2	-	5	667	c.473G>T	c.(472-474)CGC>CTC	p.R158L	TP53_uc002gig.1_Missense_Mutation_p.R158L|TP53_uc002gih.2_Missense_Mutation_p.R158L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R26L|TP53_uc010cng.1_Missense_Mutation_p.R26L|TP53_uc002gii.1_Missense_Mutation_p.R26L|TP53_uc010cnh.1_Missense_Mutation_p.R158L|TP53_uc010cni.1_Missense_Mutation_p.R158L|TP53_uc002gij.2_Missense_Mutation_p.R158L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R65L|TP53_uc002gio.2_Missense_Mutation_p.R26L|TP53_uc010vug.1_Missense_Mutation_p.R119L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158H(58)|p.R158L(55)|p.R158C(17)|p.R158G(10)|p.R158P(9)|p.0?(7)|p.R158R(6)|p.R158fs*12(5)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R158fs*11(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R65L(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.R26L(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	54	---	---	---	---	PASS
MYH4	4622	broad.mit.edu	37	17	10348599	10348599	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr17:10348599C>A	uc002gmn.2	-	36	5361	c.5250G>T	c.(5248-5250)CAG>CAT	p.Q1750H	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1750	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TGCGGGCTTCCTGGACGATGT	0.468													60	94	---	---	---	---	PASS
DHRS7B	25979	broad.mit.edu	37	17	21075445	21075445	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr17:21075445C>T	uc002gyo.2	+	2	162	c.135C>T	c.(133-135)CGC>CGT	p.R45R	DHRS7B_uc010crc.1_Silent_p.R30R	NM_015510	NP_056325	Q6IAN0	DRS7B_HUMAN	dehydrogenase/reductase (SDR family) member 7B	45	Peroxisomal (Potential).					integral to membrane|peroxisomal membrane	binding|oxidoreductase activity			pancreas(1)	1						AGTGGGTGCGCGGGAAGGCCT	0.672													12	17	---	---	---	---	PASS
ANKRD13B	124930	broad.mit.edu	37	17	27936294	27936294	+	Splice_Site	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr17:27936294G>T	uc002hei.2	+	6	868	c.755_splice	c.e6+1	p.R252_splice	ANKRD13B_uc002heh.2_Splice_Site_p.R120_splice|ANKRD13B_uc002hej.2_Splice_Site	NM_152345	NP_689558	Q86YJ7	AN13B_HUMAN	ankyrin repeat domain 13B												0						CCTTTGAGAGGTGGGTGGACA	0.622													3	18	---	---	---	---	PASS
WNK4	65266	broad.mit.edu	37	17	40940793	40940793	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr17:40940793C>A	uc002ibj.2	+	11	2156	c.2135C>A	c.(2134-2136)CCG>CAG	p.P712Q	WNK4_uc010wgx.1_Missense_Mutation_p.P376Q|WNK4_uc002ibk.1_Missense_Mutation_p.P484Q|WNK4_uc010wgy.1_Missense_Mutation_p.P56Q	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	712					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		GGGGACAGCCCGGAAGAGATT	0.532													51	63	---	---	---	---	PASS
WNT3	7473	broad.mit.edu	37	17	44895951	44895951	+	Missense_Mutation	SNP	G	T	T	rs140453711		TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr17:44895951G>T	uc002ikv.2	-	1	132	c.13C>A	c.(13-15)CTG>ATG	p.L5M		NM_030753	NP_110380	P56703	WNT3_HUMAN	wingless-type MMTV integration site family,	5					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			AGCCCGAGCAGGTGGGGCTCC	0.632													15	6	---	---	---	---	PASS
KIF2B	84643	broad.mit.edu	37	17	51902274	51902274	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr17:51902274C>A	uc002iua.2	+	1	2036	c.1880C>A	c.(1879-1881)GCT>GAT	p.A627D	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	627					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CAGGAGAGAGCTGGTGGAGTA	0.438													50	69	---	---	---	---	PASS
NOL11	25926	broad.mit.edu	37	17	65739606	65739606	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr17:65739606G>T	uc002jgd.1	+	17	1950	c.1947G>T	c.(1945-1947)TGG>TGT	p.W649C	NOL11_uc010wql.1_Missense_Mutation_p.W467C|NOL11_uc010deu.1_Missense_Mutation_p.W244C	NM_015462	NP_056277	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	649						nucleolus					0	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTATGGATTGGATATGTCTAC	0.308													11	134	---	---	---	---	PASS
MAP2K6	5608	broad.mit.edu	37	17	67519684	67519684	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr17:67519684G>T	uc002jij.2	+	8	853	c.565G>T	c.(565-567)GCT>TCT	p.A189S		NM_002758	NP_002749	P52564	MP2K6_HUMAN	mitogen-activated protein kinase kinase 6	189	Protein kinase.				activation of MAPK activity|cell cycle arrest|DNA damage induced protein phosphorylation|innate immune response|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|pancreas(1)	5	Breast(10;6.05e-10)					ACTCATCAATGCTCTCGGTCA	0.458													82	172	---	---	---	---	PASS
ITGB4	3691	broad.mit.edu	37	17	73723315	73723315	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr17:73723315G>T	uc002jpg.2	+	3	307	c.120G>T	c.(118-120)GAG>GAT	p.E40D	ITGB4_uc002jph.2_Missense_Mutation_p.E40D|ITGB4_uc010dgo.2_Missense_Mutation_p.E40D|ITGB4_uc002jpi.3_Missense_Mutation_p.E40D|ITGB4_uc010dgp.1_Missense_Mutation_p.E40D|ITGB4_uc002jpj.2_Missense_Mutation_p.E40D	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	40	PSI.|Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCTGCACGGAGTGTGTCCGTG	0.602													12	9	---	---	---	---	PASS
CEP192	55125	broad.mit.edu	37	18	13104999	13104999	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr18:13104999G>C	uc010xac.1	+	40	7048	c.6968G>C	c.(6967-6969)GGA>GCA	p.G2323A	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.G1848A|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_Missense_Mutation_p.G745A|CEP192_uc002krw.2_Missense_Mutation_p.G472A|CEP192_uc002krx.2_Missense_Mutation_p.G327A|CEP192_uc002kry.2_RNA	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	2323										ovary(4)|pancreas(1)	5						GATGAAAGTGGAGATGTTTTT	0.383													6	127	---	---	---	---	PASS
FHOD3	80206	broad.mit.edu	37	18	34174837	34174837	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr18:34174837G>T	uc002kzt.1	+	7	791	c.694G>T	c.(694-696)GTC>TTC	p.V232F	FHOD3_uc002kzr.1_Missense_Mutation_p.V232F|FHOD3_uc002kzs.1_Missense_Mutation_p.V232F|FHOD3_uc002kzu.1_Missense_Mutation_p.V57F|FHOD3_uc010dmz.1_5'UTR	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	232	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				AATTCAGGCTGTCACTGCTGT	0.517													3	42	---	---	---	---	PASS
FHOD3	80206	broad.mit.edu	37	18	34205705	34205705	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr18:34205705C>G	uc002kzt.1	+	10	1286	c.1189C>G	c.(1189-1191)CGT>GGT	p.R397G	FHOD3_uc002kzr.1_Missense_Mutation_p.R397G|FHOD3_uc002kzs.1_Missense_Mutation_p.R397G|FHOD3_uc002kzu.1_Missense_Mutation_p.R222G|FHOD3_uc010dmz.1_Missense_Mutation_p.R150G	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	397	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				GCGAGATCTGCGTGAAAAGTA	0.602													39	115	---	---	---	---	PASS
FHOD3	80206	broad.mit.edu	37	18	34359421	34359421	+	Silent	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr18:34359421C>A	uc002kzt.1	+	24	4294	c.4197C>A	c.(4195-4197)ACC>ACA	p.T1399T	FHOD3_uc002kzs.1_Silent_p.T1416T|FHOD3_uc010dmz.1_Silent_p.T1131T|FHOD3_uc010dnb.1_Missense_Mutation_p.P337H	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	1399					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				TGCGAAGAACCCTGAAGAGCG	0.577													4	64	---	---	---	---	PASS
DCC	1630	broad.mit.edu	37	18	50977006	50977006	+	Silent	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr18:50977006C>A	uc002lfe.1	+	23	3953	c.3366C>A	c.(3364-3366)ACC>ACA	p.T1122T	DCC_uc010dpf.1_Silent_p.T757T	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1122	Helical; (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGATTTGCACCCGACGCTCTT	0.483													4	58	---	---	---	---	PASS
SERPINB4	6318	broad.mit.edu	37	18	61310651	61310651	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr18:61310651C>T	uc002ljf.2	-	2	247	c.161G>A	c.(160-162)AGC>AAC	p.S54N	SERPINB4_uc002lje.2_Missense_Mutation_p.S54N|SERPINB4_uc002ljg.2_Intron	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	54					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						AGCTACCTTGCTAATTTGTTG	0.443													13	119	---	---	---	---	PASS
GNA11	2767	broad.mit.edu	37	19	3113400	3113400	+	Missense_Mutation	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:3113400A>G	uc002lxd.2	+	3	636	c.394A>G	c.(394-396)ATC>GTC	p.I132V		NM_002067	NP_002058	P29992	GNA11_HUMAN	guanine nucleotide binding protein (G protein),	132					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation|regulation of action potential	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			eye(70)|skin(16)	86		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.79e-05)|OV - Ovarian serous cystadenocarcinoma(105;2.68e-113)|Epithelial(107;1.22e-111)|all cancers(105;5.78e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00141)|STAD - Stomach adenocarcinoma(1328;0.181)		CGTCAGTGCCATCAAGACCCT	0.642			Mis		uveal melanoma								17	46	---	---	---	---	PASS
TMEM146	257062	broad.mit.edu	37	19	5733877	5733877	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:5733877C>G	uc002mda.2	+	5	348	c.287C>G	c.(286-288)CCA>CGA	p.P96R	TMEM146_uc010duj.1_5'UTR	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	96	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						GTCGGCGTACCAGAAGTGACA	0.343													11	35	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	8996331	8996331	+	Silent	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:8996331G>C	uc002mkp.2	-	61	41445	c.41241C>G	c.(41239-41241)CTC>CTG	p.L13747L	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.L564L|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13749	Extracellular (Potential).|SEA 11.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CATTGACAAAGAGGCTGTCGT	0.547													32	150	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9063537	9063537	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:9063537G>T	uc002mkp.2	-	3	24113	c.23909C>A	c.(23908-23910)CCT>CAT	p.P7970H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7972	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGAAAAGGAAGGTCTAGTTTT	0.468													4	41	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9069583	9069583	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:9069583G>T	uc002mkp.2	-	3	18067	c.17863C>A	c.(17863-17865)CTC>ATC	p.L5955I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5957	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCACAGGGAGAGCAGAAGTG	0.493													8	69	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9070657	9070657	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:9070657C>A	uc002mkp.2	-	3	16993	c.16789G>T	c.(16789-16791)GTG>TTG	p.V5597L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5599	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCCTGAGACACGGTTGAATGA	0.532													32	89	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9073626	9073626	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:9073626C>A	uc002mkp.2	-	3	14024	c.13820G>T	c.(13819-13821)AGC>ATC	p.S4607I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4609	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGGAGGGTGCTGTTCTCTTT	0.493													12	44	---	---	---	---	PASS
ZNF559	84527	broad.mit.edu	37	19	9453161	9453161	+	Missense_Mutation	SNP	G	A	A	rs138021555	byFrequency	TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:9453161G>A	uc002mlg.2	+	7	1681	c.1034G>A	c.(1033-1035)CGA>CAA	p.R345Q	ZNF559_uc002mlf.2_Missense_Mutation_p.R114Q|ZNF559_uc010dwl.1_Missense_Mutation_p.R114Q|ZNF559_uc010xkn.1_Missense_Mutation_p.R337Q|ZNF559_uc010dwm.1_3'UTR|ZNF559_uc002mle.3_Missense_Mutation_p.R409Q|ZNF559_uc010dwk.1_Missense_Mutation_p.R114Q|ZNF559_uc002mld.2_3'UTR|ZNF559_uc010dwo.1_Intron|ZNF177_uc002mli.2_Intron|ZNF177_uc002mlj.2_Intron	NM_032497	NP_115886	Q9BR84	ZN559_HUMAN	zinc finger protein 559	345	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AAACACAGGCGAACTCACACT	0.413													6	30	---	---	---	---	PASS
COL5A3	50509	broad.mit.edu	37	19	10088368	10088368	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:10088368C>T	uc002mmq.1	-	42	3114	c.3028G>A	c.(3028-3030)GGT>AGT	p.G1010S		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1010	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CCGCGCTCACCAGGGGAGCCC	0.582													3	26	---	---	---	---	PASS
KRI1	65095	broad.mit.edu	37	19	10668287	10668287	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:10668287G>C	uc002moy.1	-	16	1585	c.1576C>G	c.(1576-1578)CCC>GCC	p.P526A	KRI1_uc002mow.1_Missense_Mutation_p.P145A|KRI1_uc002mox.1_Missense_Mutation_p.P522A	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	526										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			AAGCGACAGGGCAGGTCGTCG	0.627													12	74	---	---	---	---	PASS
PODNL1	79883	broad.mit.edu	37	19	14046575	14046575	+	Missense_Mutation	SNP	C	T	T	rs150464916		TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:14046575C>T	uc002mxr.2	-	5	748	c.474G>A	c.(472-474)ATG>ATA	p.M158I	PODNL1_uc010xni.1_Missense_Mutation_p.M76I|PODNL1_uc010xnj.1_Missense_Mutation_p.M156I|PODNL1_uc002mxs.2_Intron	NM_024825	NP_079101	Q6PEZ8	PONL1_HUMAN	podocan-like 1 isoform 1	158	Leu-rich.|LRR 4.					proteinaceous extracellular matrix				central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(19;5.26e-23)			GGAAGATCTCCATCACTTGGT	0.647													6	12	---	---	---	---	PASS
OR7A10	390892	broad.mit.edu	37	19	14952633	14952633	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:14952633C>T	uc002mzx.1	-	1	57	c.57G>A	c.(55-57)GAG>GAA	p.E19E		NM_001005190	NP_001005190	O76100	OR7AA_HUMAN	olfactory receptor, family 7, subfamily A,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					ATTCTGGTTCCTCTGAAATTC	0.393													5	48	---	---	---	---	PASS
TMEM161A	54929	broad.mit.edu	37	19	19243982	19243982	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:19243982G>A	uc002nlg.2	-	3	175	c.145C>T	c.(145-147)CGG>TGG	p.R49W	TMEM161A_uc010eca.2_RNA|TMEM161A_uc002nlh.2_Missense_Mutation_p.R49W|TMEM161A_uc002nli.2_Missense_Mutation_p.R49W|TMEM161A_uc002nlj.2_5'UTR	NM_017814	NP_060284	Q9NX61	T161A_HUMAN	transmembrane protein 161A precursor	49	Extracellular (Potential).				cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)	2			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			GCCAGGGCCCGAAGCTCCTCC	0.657													12	47	---	---	---	---	PASS
GATAD2A	54815	broad.mit.edu	37	19	19612825	19612825	+	Silent	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:19612825C>A	uc010xqt.1	+	10	1860	c.1548C>A	c.(1546-1548)CGC>CGA	p.R516R	GATAD2A_uc010xqu.1_Silent_p.R145R|GATAD2A_uc010xqv.1_Silent_p.R536R|GATAD2A_uc010xqw.1_Intron	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	516					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GAGAGGCCCGCGACTGGAGTA	0.662													3	64	---	---	---	---	PASS
CILP2	148113	broad.mit.edu	37	19	19654652	19654652	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:19654652C>A	uc002nmv.3	+	8	1383	c.1298C>A	c.(1297-1299)GCC>GAC	p.A433D	CILP2_uc002nmw.3_Missense_Mutation_p.A439D	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	433						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						TGCGGGGACGCCAGCTCCCGC	0.682													8	55	---	---	---	---	PASS
ZNF98	148198	broad.mit.edu	37	19	22574571	22574571	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:22574571G>T	uc002nqt.2	-	4	1588	c.1466C>A	c.(1465-1467)CCC>CAC	p.P489H		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	489					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				ACATTTGTAGGGCTTCTCTCC	0.393													8	73	---	---	---	---	PASS
ZNF681	148213	broad.mit.edu	37	19	23926986	23926986	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:23926986C>A	uc002nrk.3	-	4	1508	c.1366G>T	c.(1366-1368)GGG>TGG	p.G456W	ZNF681_uc002nrl.3_Missense_Mutation_p.G387W|ZNF681_uc002nrj.3_Missense_Mutation_p.G387W	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	456	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				AAGGCTTTCCCACATTCTTCA	0.363													9	23	---	---	---	---	PASS
CCNE1	898	broad.mit.edu	37	19	30303902	30303902	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:30303902G>T	uc002nsn.2	+	4	321	c.138G>T	c.(136-138)ATG>ATT	p.M46I	CCNE1_uc002nso.2_Missense_Mutation_p.M31I	NM_001238	NP_001229	P24864	CCNE1_HUMAN	cyclin E1 isoform 1	46					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			lung(2)	2	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			ATGAAGAAATGGCCAAAATCG	0.552													27	59	---	---	---	---	PASS
TSHZ3	57616	broad.mit.edu	37	19	31770449	31770449	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:31770449G>C	uc002nsy.3	-	2	315	c.250C>G	c.(250-252)CGA>GGA	p.R84G		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	84					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TCAGCCATTCGGTCACTGGTC	0.587													7	44	---	---	---	---	PASS
IL28B	282617	broad.mit.edu	37	19	39735108	39735108	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:39735108G>C	uc010xut.1	-	2	211	c.207C>G	c.(205-207)TGC>TGG	p.C69W	IL28B_uc010xuu.1_Missense_Mutation_p.C69W	NM_172139	NP_742151	Q8IZI9	IL28B_HUMAN	interleukin 28B	69					response to virus	extracellular space	cytokine activity				0	all_cancers(60;2.81e-07)|all_lung(34;7.81e-08)|Lung NSC(34;9.29e-08)|all_epithelial(25;3.9e-07)|Ovarian(47;0.0315)		Epithelial(26;1.55e-27)|all cancers(26;1.41e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			AGCGGCACTTGCAGTCCTTCA	0.632													8	16	---	---	---	---	PASS
DYRK1B	9149	broad.mit.edu	37	19	40316498	40316498	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:40316498C>A	uc002omj.2	-	11	2027	c.1747G>T	c.(1747-1749)GCC>TCC	p.A583S	DYRK1B_uc002omi.2_Missense_Mutation_p.A555S|DYRK1B_uc002omk.2_Missense_Mutation_p.A543S	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	583					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			TGCTGGGGGGCAGGCGCTGGG	0.697													7	30	---	---	---	---	PASS
PLD3	23646	broad.mit.edu	37	19	40876045	40876045	+	Silent	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:40876045G>A	uc002onm.3	+	8	977	c.579G>A	c.(577-579)CAG>CAA	p.Q193Q	PLD3_uc002onj.3_Silent_p.Q193Q|PLD3_uc002onk.3_Silent_p.Q193Q|PLD3_uc002onl.3_Silent_p.Q193Q|PLD3_uc002onn.2_Silent_p.Q193Q	NM_001031696	NP_001026866	Q8IV08	PLD3_HUMAN	phospholipase D3	193	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			skin(2)|ovary(1)	3			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			TGGACATGCAGAAGCTGACCC	0.642													5	29	---	---	---	---	PASS
GRIK5	2901	broad.mit.edu	37	19	42557753	42557753	+	Splice_Site	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:42557753C>A	uc002osj.1	-	10	1304	c.1269_splice	c.e10+1	p.L423_splice	GRIK5_uc010eib.1_Splice_Site_p.L342_splice	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor							cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GGGCCACTCACCAGGATGGTT	0.622													27	30	---	---	---	---	PASS
CD177	57126	broad.mit.edu	37	19	43865645	43865645	+	Missense_Mutation	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:43865645T>A	uc002owi.2	+	9	1037	c.995T>A	c.(994-996)CTT>CAT	p.L332H	CD177_uc010eis.2_RNA|CD177_uc002owj.2_RNA	NM_020406	NP_065139	Q8N6Q3	CD177_HUMAN	CD177 molecule precursor	332	UPAR/Ly6 2.				blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)	1		Prostate(69;0.00682)				GTGCAGCCCCTTGGAACCTGT	0.597													8	37	---	---	---	---	PASS
ETHE1	23474	broad.mit.edu	37	19	44011035	44011035	+	Silent	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:44011035G>A	uc002owp.2	-	7	799	c.732C>T	c.(730-732)AAC>AAT	p.N244N	PHLDB3_uc002own.3_5'Flank|PHLDB3_uc002owo.2_5'Flank	NM_014297	NP_055112	O95571	ETHE1_HUMAN	ETHE1 protein precursor	244						mitochondrial matrix|nucleus	hydrolase activity|metal ion binding				0		Prostate(69;0.0153)				CACAGCGCATGTTGGCTGGAA	0.522													31	54	---	---	---	---	PASS
RSPH6A	81492	broad.mit.edu	37	19	46308014	46308014	+	Silent	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:46308014G>A	uc002pdm.2	-	3	1292	c.1149C>T	c.(1147-1149)GTC>GTT	p.V383V	RSPH6A_uc002pdl.2_Silent_p.V119V	NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	383	Glu-rich.					intracellular				ovary(1)|central_nervous_system(1)	2						gcgcctccATGACCTCGCCAC	0.353													10	8	---	---	---	---	PASS
PTGIR	5739	broad.mit.edu	37	19	47127253	47127253	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:47127253C>G	uc002pex.2	-	2	343	c.230G>C	c.(229-231)CGC>CCC	p.R77P		NM_000960	NP_000951	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	77	Extracellular (Potential).				cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	GGAGCTGTTGCGCGCATAGGC	0.716													2	1	---	---	---	---	PASS
LMTK3	114783	broad.mit.edu	37	19	49004555	49004555	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:49004555C>T	uc002pjk.2	-	10	1073	c.1073G>A	c.(1072-1074)CGC>CAC	p.R358H		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GTTGCTCTCGCGGCTCTGGTC	0.657													22	98	---	---	---	---	PASS
PIH1D1	55011	broad.mit.edu	37	19	49952853	49952853	+	Silent	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:49952853G>A	uc002pns.2	-	3	500	c.216C>T	c.(214-216)TCC>TCT	p.S72S	PIH1D1_uc010yap.1_Missense_Mutation_p.P103S|PIH1D1_uc010yaq.1_Silent_p.S72S	NM_017916	NP_060386	Q9NWS0	PIHD1_HUMAN	NOP17	72					box C/D snoRNP assembly	pre-snoRNP complex					0		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00152)|GBM - Glioblastoma multiforme(486;0.0244)		GGATAGAGGGGGAGTGGCAGA	0.547													17	56	---	---	---	---	PASS
SIGLEC12	89858	broad.mit.edu	37	19	52004699	52004699	+	Missense_Mutation	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:52004699C>T	uc002pwx.1	-	1	345	c.289G>A	c.(289-291)GGG>AGG	p.G97R	SIGLEC12_uc002pww.1_5'Flank|SIGLEC12_uc010eoy.1_5'UTR	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	97	Ig-like V-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TGTGGGTCCCCAAGGAGGTGG	0.537													72	145	---	---	---	---	PASS
SIGLEC12	89858	broad.mit.edu	37	19	52004757	52004757	+	Silent	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:52004757G>T	uc002pwx.1	-	1	287	c.231C>A	c.(229-231)GCC>GCA	p.A77A	SIGLEC12_uc002pww.1_5'Flank|SIGLEC12_uc010eoy.1_5'UTR	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	77	Ig-like V-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GGTTGTTTGTGGCCACTGGAA	0.577													13	99	---	---	---	---	PASS
ZNF808	388558	broad.mit.edu	37	19	53050785	53050785	+	Missense_Mutation	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:53050785T>A	uc010epq.1	+	4	261	c.84T>A	c.(82-84)GAT>GAA	p.D28E	ZNF808_uc002pzq.2_Intron	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	28	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		CTTTCAGGGATGTGGCTATAG	0.423													37	178	---	---	---	---	PASS
LILRB1	10859	broad.mit.edu	37	19	55144079	55144079	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:55144079G>T	uc002qgj.2	+	7	1166	c.826G>T	c.(826-828)GGG>TGG	p.G276W	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.G276W|LILRB1_uc002qgk.2_Missense_Mutation_p.G276W|LILRB1_uc002qgm.2_Missense_Mutation_p.G276W|LILRB1_uc010erq.2_Missense_Mutation_p.G276W|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	276	Ig-like C2-type 3.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		GCCCCAGGCTGGGCTCTCCCA	0.612										HNSCC(37;0.09)			36	52	---	---	---	---	PASS
NLRP5	126206	broad.mit.edu	37	19	56539855	56539855	+	Silent	SNP	A	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:56539855A>G	uc002qmj.2	+	7	2256	c.2256A>G	c.(2254-2256)GCA>GCG	p.A752A	NLRP5_uc002qmi.2_Silent_p.A733A	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	752	LRR 2.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CCGCTGAGGCATGTCCTGTGG	0.517													52	223	---	---	---	---	PASS
ZNF460	10794	broad.mit.edu	37	19	57802733	57802733	+	Missense_Mutation	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:57802733G>A	uc002qog.2	+	3	1146	c.824G>A	c.(823-825)AGT>AAT	p.S275N	ZNF460_uc010ygv.1_Missense_Mutation_p.S234N	NM_006635	NP_006626	Q14592	ZN460_HUMAN	zinc finger protein 460	275					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CGGGTTCACAGTGGAGAGAAG	0.502													41	59	---	---	---	---	PASS
ZSCAN1	284312	broad.mit.edu	37	19	58564832	58564832	+	Missense_Mutation	SNP	T	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:58564832T>G	uc002qrc.1	+	6	887	c.640T>G	c.(640-642)TGG>GGG	p.W214G		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	214					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GCCGAGTATCTGGGACGAGCC	0.632													34	41	---	---	---	---	PASS
ZNF135	7694	broad.mit.edu	37	19	58579628	58579628	+	Silent	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr19:58579628G>T	uc010yhq.1	+	5	1908	c.1812G>T	c.(1810-1812)TCG>TCT	p.S604S	ZNF135_uc002qre.2_Silent_p.S592S|ZNF135_uc002qrd.1_Intron|ZNF135_uc002qrf.2_Silent_p.S550S|ZNF135_uc002qrg.2_Silent_p.S562S|ZNF135_uc010yhr.1_Silent_p.S413S	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	604					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		ACAGCTCCTCGCTCAGCCAGC	0.552													53	53	---	---	---	---	PASS
SIRPB1	10326	broad.mit.edu	37	20	1551566	1551566	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr20:1551566C>A	uc010gai.2	-	4	1068	c.969G>T	c.(967-969)AGG>AGT	p.R323S	SIRPB1_uc002wfk.3_Intron	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	323	Ig-like C1-type 2.|Extracellular (Potential).				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						CCACATCGTCCCTGTGGGCAC	0.562													62	77	---	---	---	---	PASS
GFRA4	64096	broad.mit.edu	37	20	3640822	3640822	+	Nonsense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr20:3640822C>A	uc002wio.2	-	4	802	c.802G>T	c.(802-804)GAG>TAG	p.E268*	GFRA4_uc002win.2_Nonsense_Mutation_p.E238*	NM_145762	NP_665705	Q9GZZ7	GFRA4_HUMAN	GDNF family receptor alpha 4 isoform b	268						anchored to membrane|extracellular region|plasma membrane	receptor activity				0						AGGCTGTGCTCCGGGTCTCCC	0.672													9	18	---	---	---	---	PASS
ADAM33	80332	broad.mit.edu	37	20	3655185	3655185	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr20:3655185C>G	uc002wit.2	-	6	653	c.566G>C	c.(565-567)GGC>GCC	p.G189A	ADAM33_uc002wir.1_Missense_Mutation_p.G189A|ADAM33_uc002wis.2_5'Flank|ADAM33_uc002wiu.2_Missense_Mutation_p.G189A|ADAM33_uc002wiw.1_Intron|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron|ADAM33_uc002wix.1_Intron|ADAM33_uc010zqg.1_Missense_Mutation_p.G201A|ADAM33_uc010zqh.1_Missense_Mutation_p.G189A	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	189	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						GCTGGTCATGCCCGCTTTGTT	0.582													24	81	---	---	---	---	PASS
PLCB4	5332	broad.mit.edu	37	20	9382159	9382159	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr20:9382159C>A	uc002wnf.2	+	19	1669	c.1533C>A	c.(1531-1533)CAC>CAA	p.H511Q	PLCB4_uc010gbw.1_Missense_Mutation_p.H511Q|PLCB4_uc010gbx.2_Missense_Mutation_p.H511Q|PLCB4_uc002wne.2_Missense_Mutation_p.H511Q|PLCB4_uc002wnh.2_Missense_Mutation_p.H358Q	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	511					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						AGGAAGCTCACCCCGAATTCA	0.448													20	26	---	---	---	---	PASS
C20orf26	26074	broad.mit.edu	37	20	20340853	20340853	+	Splice_Site	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr20:20340853G>T	uc002wru.2	+	27	3590	c.3514_splice	c.e27-1	p.E1172_splice	C20orf26_uc002wrw.2_Splice_Site	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074											ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		GTGTTTTACAGGAGGAAGATC	0.428											OREG0025807	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	131	---	---	---	---	PASS
C20orf26	26074	broad.mit.edu	37	20	20340854	20340854	+	Nonsense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr20:20340854G>T	uc002wru.2	+	27	3590	c.3514G>T	c.(3514-3516)GAG>TAG	p.E1172*	C20orf26_uc002wrw.2_RNA	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	1172										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		TGTTTTACAGGAGGAAGATCT	0.428											OREG0025807	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	131	---	---	---	---	PASS
GSS	2937	broad.mit.edu	37	20	33516668	33516668	+	Missense_Mutation	SNP	G	T	T	rs142494184	by1000genomes	TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr20:33516668G>T	uc002xbg.2	-	13	1468	c.1388C>A	c.(1387-1389)GCG>GAG	p.A463E	GSS_uc010zun.1_Missense_Mutation_p.A335E|GSS_uc010zuo.1_Missense_Mutation_p.A352E|GSS_uc010zup.1_Missense_Mutation_p.A394E|GSS_uc002xbh.2_RNA	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	463					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	TGCCACTCCCGCTGCCACACC	0.542													8	46	---	---	---	---	PASS
FAM83D	81610	broad.mit.edu	37	20	37580988	37580988	+	Missense_Mutation	SNP	A	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr20:37580988A>T	uc002xjg.2	+	4	1714	c.1673A>T	c.(1672-1674)AAC>ATC	p.N558I		NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	528					cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)				AGAAACTTGAACAAAGAGCGG	0.512													22	78	---	---	---	---	PASS
PTPRT	11122	broad.mit.edu	37	20	41419868	41419868	+	Silent	SNP	G	T	T	rs140340339		TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr20:41419868G>T	uc002xkg.2	-	3	637	c.453C>A	c.(451-453)CTC>CTA	p.L151L	PTPRT_uc010ggj.2_Silent_p.L151L	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	151	Extracellular (Potential).|MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity	p.L151L(1)		skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGCTGATGGCGAGCTCTGCCT	0.488													32	126	---	---	---	---	PASS
TTPAL	79183	broad.mit.edu	37	20	43113110	43113110	+	Silent	SNP	T	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr20:43113110T>C	uc002xmc.1	+	4	703	c.579T>C	c.(577-579)AGT>AGC	p.S193S	TTPAL_uc002xmd.1_Silent_p.S193S|TTPAL_uc010ggr.1_Intron	NM_024331	NP_077307	Q9BTX7	TTPAL_HUMAN	tocopherol (alpha) transfer protein-like	193	CRAL-TRIO.					intracellular	transporter activity			breast(1)	1						AAGGAGTGAGTTTATCAAAAG	0.428													15	68	---	---	---	---	PASS
KCNJ6	3763	broad.mit.edu	37	21	39086791	39086791	+	Silent	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr21:39086791C>G	uc011aej.1	-	3	722	c.669G>C	c.(667-669)CGG>CGC	p.R223R	KCNJ6_uc002ywo.2_Silent_p.R223R	NM_002240	NP_002231	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel J6	223	Cytoplasmic (By similarity).				synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1					Halothane(DB01159)	GGTCCCCTACCCGGAACATCA	0.517													13	76	---	---	---	---	PASS
MX1	4599	broad.mit.edu	37	21	42807802	42807802	+	Silent	SNP	G	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr21:42807802G>A	uc002yzh.2	+	8	1091	c.144G>A	c.(142-144)AAG>AAA	p.K48K	MX1_uc002yzi.2_Silent_p.K48K|MX1_uc010goq.2_Silent_p.K48K	NM_001144925	NP_001138397	P20591	MX1_HUMAN	myxovirus resistance protein 1	48					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				ATGAGGAGAAGGTGCGCCCCT	0.547													31	98	---	---	---	---	PASS
DEPDC5	9681	broad.mit.edu	37	22	32215144	32215144	+	Silent	SNP	C	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr22:32215144C>T	uc003als.2	+	22	1945	c.1803C>T	c.(1801-1803)TTC>TTT	p.F601F	DEPDC5_uc011als.1_Silent_p.F601F|DEPDC5_uc011alu.1_Silent_p.F601F|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Silent_p.F601F|DEPDC5_uc003alu.2_Silent_p.F41F|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alt.1_Silent_p.F573F	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	601					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						TTAACCCCTTCGCTCCCTCTC	0.498													29	89	---	---	---	---	PASS
TCF20	6942	broad.mit.edu	37	22	42605710	42605710	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr22:42605710C>A	uc003bcj.1	-	1	5736	c.5602G>T	c.(5602-5604)GTT>TTT	p.V1868F	TCF20_uc003bck.1_Missense_Mutation_p.V1868F|TCF20_uc003bnt.2_Missense_Mutation_p.V1868F	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1868					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						CTGCCACAAACCAGGTAGATT	0.468													53	117	---	---	---	---	PASS
EFCAB6	64800	broad.mit.edu	37	22	44031098	44031098	+	Splice_Site	SNP	T	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr22:44031098T>C	uc003bdy.1	-	18	2199	c.1984_splice	c.e18-1	p.V662_splice	EFCAB6_uc003bdz.1_Splice_Site_p.V510_splice|EFCAB6_uc010gzi.1_Splice_Site_p.V510_splice|EFCAB6_uc010gzj.1_Intron|EFCAB6_uc010gzk.1_Intron	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				TTCCAGTACCTGACGAGGGAG	0.567													20	51	---	---	---	---	PASS
MOV10L1	54456	broad.mit.edu	37	22	50547272	50547272	+	Nonsense_Mutation	SNP	C	T	T	rs138868385		TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr22:50547272C>T	uc003bjj.2	+	5	825	c.742C>T	c.(742-744)CGA>TGA	p.R248*	MOV10L1_uc003bjk.3_Nonsense_Mutation_p.R248*|MOV10L1_uc011arp.1_Nonsense_Mutation_p.R228*	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	248					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		AGTGAAGAGGCGGTAAGAAAA	0.313													5	52	---	---	---	---	PASS
SHANK3	85358	broad.mit.edu	37	22	51143492	51143492	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr22:51143492G>T	uc003bne.1	+	17	2045	c.2045G>T	c.(2044-2046)AGG>ATG	p.R682M	SHANK3_uc003bnf.1_Missense_Mutation_p.R137M	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	682										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		TCTGTGACAAGGAAGCCAGAA	0.597													20	44	---	---	---	---	PASS
SHANK3	85358	broad.mit.edu	37	22	51143493	51143493	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr22:51143493G>T	uc003bne.1	+	17	2046	c.2046G>T	c.(2044-2046)AGG>AGT	p.R682S	SHANK3_uc003bnf.1_Missense_Mutation_p.R137S	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	682										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		CTGTGACAAGGAAGCCAGAAG	0.597													19	43	---	---	---	---	PASS
FAM48B2	170067	broad.mit.edu	37	X	24330733	24330733	+	Missense_Mutation	SNP	G	T	T			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chrX:24330733G>T	uc011mjw.1	-	1	700	c.700C>A	c.(700-702)CCG>ACG	p.P234T		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2	234											0						TGTTCCATCGGGTCGGTATTC	0.527													27	39	---	---	---	---	PASS
PCYT1B	9468	broad.mit.edu	37	X	24580609	24580609	+	Missense_Mutation	SNP	T	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chrX:24580609T>A	uc004dbi.2	-	8	1144	c.911A>T	c.(910-912)CAG>CTG	p.Q304L	PCYT1B_uc004dbk.3_Missense_Mutation_p.Q304L|PCYT1B_uc004dbj.2_Missense_Mutation_p.Q286L	NM_004845	NP_004836	Q9Y5K3	PCY1B_HUMAN	choline phosphate cytidylyltransferase 1 beta	304						endoplasmic reticulum	choline-phosphate cytidylyltransferase activity				0					Choline(DB00122)	GCTCCTCTCCTGGAACATCTG	0.567													3	7	---	---	---	---	PASS
MAGEB1	4112	broad.mit.edu	37	X	30269093	30269093	+	Missense_Mutation	SNP	T	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chrX:30269093T>G	uc004dcc.2	+	4	803	c.483T>G	c.(481-483)TTT>TTG	p.F161L	MAGEB1_uc004dcd.2_Missense_Mutation_p.F161L|MAGEB1_uc004dce.2_Missense_Mutation_p.F161L	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	161	MAGE.										0						AGCTCGTCTTTGGCCTTGATT	0.478													6	14	---	---	---	---	PASS
FAM47B	170062	broad.mit.edu	37	X	34961941	34961941	+	Silent	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chrX:34961941C>G	uc004ddi.1	+	1	1011	c.993C>G	c.(991-993)CTC>CTG	p.L331L		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	331										ovary(3)|breast(1)	4						TGTCCCATCTCTGCCTGGAAC	0.587													15	29	---	---	---	---	PASS
DGKK	139189	broad.mit.edu	37	X	50167245	50167245	+	Splice_Site	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chrX:50167245C>A	uc010njr.1	-	2	816	c.756_splice	c.e2+1	p.A252_splice		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					CTATACATTACCGCGGGATGG	0.418													13	23	---	---	---	---	PASS
WNK3	65267	broad.mit.edu	37	X	54264800	54264800	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chrX:54264800C>A	uc004dtd.1	-	19	4287	c.3848G>T	c.(3847-3849)GGA>GTA	p.G1283V	WNK3_uc004dtc.1_Missense_Mutation_p.G1330V	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1283					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						CTGAAATGATCCACTCATCGC	0.443													16	24	---	---	---	---	PASS
KIAA2022	340533	broad.mit.edu	37	X	73963349	73963349	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chrX:73963349C>A	uc004eby.2	-	3	1660	c.1043G>T	c.(1042-1044)CGA>CTA	p.R348L		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	348					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						CTTAGACTCTCGCTTGGGGCA	0.473													18	33	---	---	---	---	PASS
ZMAT1	84460	broad.mit.edu	37	X	101159199	101159199	+	Nonsense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chrX:101159199C>A	uc011mrl.1	-	3	537	c.226G>T	c.(226-228)GAG>TAG	p.E76*	ZMAT1_uc004ein.2_5'UTR|ZMAT1_uc011mrm.1_5'UTR	NM_001011657	NP_001011657	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 1	Error:Variant_position_missing_in_A7MD47_after_alignment						nucleus	zinc ion binding			ovary(1)	1						TAACCTACCTCATAATGTGAA	0.289													6	13	---	---	---	---	PASS
RGAG1	57529	broad.mit.edu	37	X	109694561	109694561	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chrX:109694561C>G	uc004eor.1	+	3	962	c.716C>G	c.(715-717)ACC>AGC	p.T239S	RGAG1_uc011msr.1_Missense_Mutation_p.T239S	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	239										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						GATGAAGACACCGAAGCAATG	0.468													38	49	---	---	---	---	PASS
WDR44	54521	broad.mit.edu	37	X	117566799	117566799	+	Missense_Mutation	SNP	G	C	C			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chrX:117566799G>C	uc004eqn.2	+	13	2218	c.1793G>C	c.(1792-1794)CGG>CCG	p.R598P	WDR44_uc004eqo.2_Missense_Mutation_p.R598P|WDR44_uc011mtr.1_Missense_Mutation_p.R573P|WDR44_uc010nqi.2_Missense_Mutation_p.R308P	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	598						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						TTTCGGCAACGGCCATTTTGC	0.343													41	66	---	---	---	---	PASS
MAGEC2	51438	broad.mit.edu	37	X	141290679	141290679	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chrX:141290679C>A	uc004fbu.1	-	3	1443	c.1095G>T	c.(1093-1095)ATG>ATT	p.M365I		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	365						cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CGTTGCTGGACATGACACTGA	0.498										HNSCC(46;0.14)			13	77	---	---	---	---	PASS
GABRQ	55879	broad.mit.edu	37	X	151821077	151821077	+	Missense_Mutation	SNP	C	A	A			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chrX:151821077C>A	uc004ffp.1	+	9	1252	c.1232C>A	c.(1231-1233)CCG>CAG	p.P411Q		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	411						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CTGGCAAGCCCGGAAAGCCTC	0.617													23	24	---	---	---	---	PASS
NAA10	8260	broad.mit.edu	37	X	153195481	153195481	+	Missense_Mutation	SNP	C	G	G			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chrX:153195481C>G	uc004fjm.1	-	8	778	c.667G>C	c.(667-669)GAT>CAT	p.D223H	NAA10_uc004fjn.1_Missense_Mutation_p.D208H	NM_003491	NP_003482	P41227	NAA10_HUMAN	alpha-N-acetyltransferase 1A	223					DNA packaging|internal protein amino acid acetylation|N-terminal protein amino acid acetylation	cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)	1						TCCTTGACATCTGTGCTCTCT	0.617													7	33	---	---	---	---	PASS
PLEC	5339	broad.mit.edu	37	8	144993989	144993997	+	In_Frame_Del	DEL	CGTCCTTGA	-	-			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr8:144993989_144993997delCGTCCTTGA	uc003zaf.1	-	32	10573_10581	c.10403_10411delTCAAGGACG	c.(10402-10413)CTCAAGGACGGC>CGC	p.3468_3471LKDG>R	PLEC_uc003zab.1_In_Frame_Del_p.3331_3334LKDG>R|PLEC_uc003zac.1_In_Frame_Del_p.3335_3338LKDG>R|PLEC_uc003zad.2_In_Frame_Del_p.3331_3334LKDG>R|PLEC_uc003zae.1_In_Frame_Del_p.3299_3302LKDG>R|PLEC_uc003zag.1_In_Frame_Del_p.3309_3312LKDG>R|PLEC_uc003zah.2_In_Frame_Del_p.3317_3320LKDG>R|PLEC_uc003zaj.2_In_Frame_Del_p.3358_3361LKDG>R	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3468_3471	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GTCGTCTTGCCGTCCTTGAGCTGCTCAAA	0.670													59	31	---	---	---	---	
Unknown	0	broad.mit.edu	37	11	43283606	43283606	+	RNA	DEL	A	-	-			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr11:43283606delA	uc001mxe.1	-	2		c.1330delT								Homo sapiens cDNA FLJ44864 fis, clone BRALZ2013621, moderately similar to Heterogeneous nuclear ribonucleoprotein K.																		AAGCAAATGTAAAAAAAAAAA	0.388													5	3	---	---	---	---	
CNDP2	55748	broad.mit.edu	37	18	72183485	72183485	+	Frame_Shift_Del	DEL	G	-	-			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chr18:72183485delG	uc002llm.1	+	9	1088	c.926delG	c.(925-927)TGGfs	p.W309fs	CNDP2_uc002lln.1_Frame_Shift_Del_p.W225fs|CNDP2_uc010dqs.2_Intron	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	309						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		ATGCACCGATGGCGGTACCCG	0.582													175	91	---	---	---	---	
GPR174	84636	broad.mit.edu	37	X	78427401	78427401	+	Frame_Shift_Del	DEL	C	-	-			TCGA-63-6202-01A-11D-1817-08	TCGA-63-6202-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	a3c568a6-0c43-47a7-a35a-3225fedeeb44	fd9f3633-3955-4760-8e4f-6fbed792b860	g.chrX:78427401delC	uc004edg.1	+	1	933	c.897delC	c.(895-897)TTCfs	p.F299fs		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	299	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						CTAATGAGTTCCGAAGACGGC	0.408										HNSCC(63;0.18)			33	23	---	---	---	---