Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
GRIK3	2899	broad.mit.edu	37	1	37271849	37271849	+	Nonsense_Mutation	SNP	C	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr1:37271849C>A	uc001caz.2	-	14	2305	c.2170G>T	c.(2170-2172)GAG>TAG	p.E724*	GRIK3_uc001cba.1_Nonsense_Mutation_p.E724*	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	724	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TGGATGCCCTCCTCGTTGTTC	0.602													10	54	---	---	---	---	PASS
HIVEP3	59269	broad.mit.edu	37	1	42049199	42049199	+	Nonsense_Mutation	SNP	G	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr1:42049199G>A	uc001cgz.3	-	4	2483	c.1270C>T	c.(1270-1272)CGA>TGA	p.R424*	HIVEP3_uc001cha.3_Nonsense_Mutation_p.R424*|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	424	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TGTCCTATTCGCCCACACTTG	0.607													6	67	---	---	---	---	PASS
CYP4A22	284541	broad.mit.edu	37	1	47614361	47614361	+	Silent	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr1:47614361C>T	uc001cqv.1	+	12	1503	c.1452C>T	c.(1450-1452)CCC>CCT	p.P484P		NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	484						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						TGCCTGATCCCACCAGGATCC	0.577													12	104	---	---	---	---	PASS
SLC5A9	200010	broad.mit.edu	37	1	48705040	48705040	+	Missense_Mutation	SNP	G	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr1:48705040G>A	uc001cro.2	+	12	1560	c.1508G>A	c.(1507-1509)CGT>CAT	p.R503H	SLC5A9_uc001crn.2_Missense_Mutation_p.R528H|SLC5A9_uc010omt.1_Missense_Mutation_p.R517H|SLC5A9_uc001crp.2_Missense_Mutation_p.R170H|SLC5A9_uc010omu.1_Missense_Mutation_p.R170H|SLC5A9_uc009vyt.1_RNA	NM_001011547	NP_001011547	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/glucose	503	Helical; (Potential).					integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			ovary(3)	3						GGGCTTCTGCGTATGATCCTG	0.597													21	83	---	---	---	---	PASS
C8A	731	broad.mit.edu	37	1	57372362	57372362	+	Silent	SNP	G	A	A	rs147666641	byFrequency	TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr1:57372362G>A	uc001cyo.2	+	8	1251	c.1119G>A	c.(1117-1119)ACG>ACA	p.T373T		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	373	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						GAGATATCACGACATGTTTTG	0.393													20	90	---	---	---	---	PASS
C1orf173	127254	broad.mit.edu	37	1	75037915	75037915	+	Missense_Mutation	SNP	G	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr1:75037915G>A	uc001dgg.2	-	14	3698	c.3479C>T	c.(3478-3480)ACG>ATG	p.T1160M		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1160	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						AAATCCAGGCGTTGCTTCAAA	0.473													6	95	---	---	---	---	PASS
DNAJB4	11080	broad.mit.edu	37	1	78479055	78479055	+	Missense_Mutation	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr1:78479055C>T	uc001dij.2	+	2	691	c.532C>T	c.(532-534)CGG>TGG	p.R178W	DNAJB4_uc010orn.1_Missense_Mutation_p.R63W	NM_007034	NP_008965	Q9UDY4	DNJB4_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 4	178					protein folding|response to heat|response to unfolded protein	cytoplasm|plasma membrane	heat shock protein binding|unfolded protein binding				0						TTGTACCAAACGGATGAAGAT	0.408													4	90	---	---	---	---	PASS
NCOA1	8648	broad.mit.edu	37	2	24928059	24928059	+	Missense_Mutation	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr2:24928059C>T	uc002rfk.2	+	10	1312	c.1054C>T	c.(1054-1056)CCA>TCA	p.P352S	NCOA1_uc010eye.2_Missense_Mutation_p.P352S|NCOA1_uc002rfi.2_Missense_Mutation_p.P201S|NCOA1_uc002rfj.2_Missense_Mutation_p.P352S|NCOA1_uc002rfl.2_Missense_Mutation_p.P352S	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	352									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCTCAAAGTCCAGACATGCA	0.428			T	PAX3	alveolar rhadomyosarcoma								5	122	---	---	---	---	PASS
SLC8A1	6546	broad.mit.edu	37	2	40656545	40656545	+	Silent	SNP	G	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr2:40656545G>A	uc002rrx.2	-	1	900	c.876C>T	c.(874-876)GAC>GAT	p.D292D	SLC8A1_uc002rry.2_Silent_p.D292D|SLC8A1_uc002rrz.2_Silent_p.D292D|SLC8A1_uc002rsa.2_Silent_p.D292D|SLC8A1_uc002rsd.3_Silent_p.D292D|SLC8A1_uc002rsb.1_Silent_p.D292D|SLC8A1_uc010fan.1_Silent_p.D292D|SLC8A1_uc002rsc.1_Silent_p.D292D	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	292	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CCACTTTCCCGTCCATTTCAA	0.443													37	221	---	---	---	---	PASS
TUBA3E	112714	broad.mit.edu	37	2	130951985	130951985	+	Missense_Mutation	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr2:130951985C>T	uc002tqv.2	-	4	531	c.430G>A	c.(430-432)GGC>AGC	p.G144S		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	144	GTP (Potential).				microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)					GAGCCAGTGCCGCCCCCAAAG	0.577													15	45	---	---	---	---	PASS
SLC40A1	30061	broad.mit.edu	37	2	190437668	190437668	+	Silent	SNP	C	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr2:190437668C>A	uc002uqp.3	-	4	642	c.291G>T	c.(289-291)GTG>GTT	p.V97V	SLC40A1_uc002uqq.2_Silent_p.V97V	NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated	97	Helical; (Potential).				anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			CATTCTGTACCACCAGCGAGG	0.428													4	92	---	---	---	---	PASS
COL6A3	1293	broad.mit.edu	37	2	238274445	238274445	+	Missense_Mutation	SNP	C	T	T	rs113251155		TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr2:238274445C>T	uc002vwl.2	-	12	6019	c.5734G>A	c.(5734-5736)GAG>AAG	p.E1912K	COL6A3_uc002vwo.2_Missense_Mutation_p.E1706K|COL6A3_uc010znj.1_Missense_Mutation_p.E1305K	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1912	VWFA 10.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CGGAACTTCTCGAGCATCTCT	0.632													7	69	---	---	---	---	PASS
BOK	666	broad.mit.edu	37	2	242511723	242511723	+	Silent	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr2:242511723C>T	uc002wbq.2	+	5	771	c.525C>T	c.(523-525)CTC>CTT	p.L175L	BOK_uc002wbr.2_5'Flank	NM_032515	NP_115904	Q9UMX3	BOK_HUMAN	BCL2-related ovarian killer	175	BH2.				activation of caspase activity|cell proliferation|signal transduction by p53 class mediator resulting in induction of apoptosis	mitochondrial membrane|nucleus				ovary(1)	1		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.04e-33)|all cancers(36;7.87e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.52e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.64e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0835)		CTGATGTCCTCAAGTGTGTGG	0.652													4	20	---	---	---	---	PASS
ZBTB11	27107	broad.mit.edu	37	3	101390091	101390091	+	Missense_Mutation	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr3:101390091C>T	uc003dve.3	-	3	891	c.661G>A	c.(661-663)GAA>AAA	p.E221K	ZBTB11_uc003dvf.2_3'UTR	NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	221	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TCTTCTCCTTCAATTAACAAA	0.383													15	103	---	---	---	---	PASS
PRDM9	56979	broad.mit.edu	37	5	23526956	23526956	+	Silent	SNP	C	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr5:23526956C>A	uc003jgo.2	+	11	1941	c.1759C>A	c.(1759-1761)CGG>AGG	p.R587R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	587	C2H2-type 4.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GGAGTGTGGGCGGGGCTTTAG	0.607										HNSCC(3;0.000094)			7	105	---	---	---	---	PASS
MSH3	4437	broad.mit.edu	37	5	79950593	79950593	+	Nonsense_Mutation	SNP	C	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr5:79950593C>A	uc003kgz.2	+	1	300	c.47C>A	c.(46-48)TCA>TAA	p.S16*	DHFR_uc011ctl.1_5'UTR|DHFR_uc011ctm.1_5'UTR|DHFR_uc010jap.1_RNA|DHFR_uc003kgx.1_Nonsense_Mutation_p.E55*|DHFR_uc003kgy.1_5'UTR	NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	16					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		GCCTCCAGCTCAGCCCCTGCG	0.687								MMR					3	26	---	---	---	---	PASS
PCDHA8	56140	broad.mit.edu	37	5	140222774	140222774	+	Missense_Mutation	SNP	G	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr5:140222774G>A	uc003lhs.2	+	1	1868	c.1868G>A	c.(1867-1869)CGC>CAC	p.R623H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.R623H	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	623	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCCCGTTCCGCGTGGGGCTG	0.642													9	110	---	---	---	---	PASS
UNC5A	90249	broad.mit.edu	37	5	176305332	176305332	+	Missense_Mutation	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr5:176305332C>T	uc003mey.2	+	12	2149	c.1957C>T	c.(1957-1959)CGC>TGC	p.R653C		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	653	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCACAACCTGCGCCTATCCAT	0.627													10	55	---	---	---	---	PASS
TIAM2	26230	broad.mit.edu	37	6	155577880	155577880	+	Missense_Mutation	SNP	G	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr6:155577880G>T	uc003qqb.2	+	29	6004	c.4731G>T	c.(4729-4731)CAG>CAT	p.Q1577H	TIAM2_uc003qqe.2_Missense_Mutation_p.Q1577H|TIAM2_uc010kjj.2_Missense_Mutation_p.Q1139H|TIAM2_uc003qqf.2_Missense_Mutation_p.Q953H|TIAM2_uc011efl.1_Missense_Mutation_p.Q921H|TIAM2_uc003qqg.2_Missense_Mutation_p.Q889H|TIAM2_uc003qqh.2_Missense_Mutation_p.Q502H|uc003qqi.1_5'Flank	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1577					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		ACCACCGTCAGACTGTGAAGC	0.537													16	49	---	---	---	---	PASS
FAM40B	57464	broad.mit.edu	37	7	129122858	129122858	+	Missense_Mutation	SNP	G	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr7:129122858G>A	uc011koy.1	+	20	2265	c.2225G>A	c.(2224-2226)CGC>CAC	p.R742H	FAM40B_uc003vow.2_Missense_Mutation_p.R742H|FAM40B_uc011koz.1_Missense_Mutation_p.R234H	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a	742											0						GTGCGTCACCGCATGAACGAT	0.448													4	67	---	---	---	---	PASS
KIAA1549	57670	broad.mit.edu	37	7	138601663	138601663	+	Silent	SNP	G	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr7:138601663G>A	uc011kql.1	-	2	2758	c.2709C>T	c.(2707-2709)GAC>GAT	p.D903D	KIAA1549_uc003vuk.3_Silent_p.D853D|KIAA1549_uc011kqj.1_Silent_p.D903D	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	903						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						GACTTGCGGCGTCACCCATCA	0.622			O	BRAF	pilocytic astrocytoma								5	25	---	---	---	---	PASS
ATP6V1H	51606	broad.mit.edu	37	8	54682288	54682288	+	Nonsense_Mutation	SNP	G	C	C	rs113474015		TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr8:54682288G>C	uc003xrl.2	-	11	1217	c.1065C>G	c.(1063-1065)TAC>TAG	p.Y355*	ATP6V1H_uc003xrk.2_Nonsense_Mutation_p.Y315*|ATP6V1H_uc003xrm.2_Nonsense_Mutation_p.Y355*|ATP6V1H_uc003xrn.2_Nonsense_Mutation_p.Y337*|ATP6V1H_uc011ldv.1_Nonsense_Mutation_p.Y275*|ATP6V1H_uc010lyd.2_Nonsense_Mutation_p.Y291*	NM_213620	NP_998785	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1	355					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism				0		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			GTTCTGAACTGTATTCATCAA	0.313													11	46	---	---	---	---	PASS
HAS2	3037	broad.mit.edu	37	8	122641065	122641065	+	Silent	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr8:122641065C>T	uc003yph.2	-	2	1054	c.516G>A	c.(514-516)ACG>ACA	p.T172T		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	172	Cytoplasmic (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			AGACCAATTGCGTTACGTGTT	0.458													38	327	---	---	---	---	PASS
CYP11B2	1585	broad.mit.edu	37	8	143999120	143999120	+	Missense_Mutation	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr8:143999120C>T	uc003yxk.1	-	1	140	c.137G>A	c.(136-138)GGC>GAC	p.G46D		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	46					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CCACCTGTTGCCTGGATGCTG	0.647									Familial_Hyperaldosteronism_type_I				11	93	---	---	---	---	PASS
KIAA2026	158358	broad.mit.edu	37	9	5988344	5988344	+	Splice_Site	SNP	C	G	G			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr9:5988344C>G	uc003zjq.3	-	2	1010	c.794_splice	c.e2+1	p.R265_splice		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358											ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TTAACATTTACCTTTTTTCTT	0.353													3	52	---	---	---	---	PASS
BNC2	54796	broad.mit.edu	37	9	16419078	16419078	+	Missense_Mutation	SNP	C	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr9:16419078C>A	uc003zml.2	-	7	3349	c.3209G>T	c.(3208-3210)TGC>TTC	p.C1070F	BNC2_uc011lmw.1_Missense_Mutation_p.C975F|BNC2_uc003zmm.2_3'UTR|BNC2_uc011lmv.1_3'UTR|BNC2_uc003zmj.2_3'UTR|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.C857F	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	1070	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		CATCATATTGCAACCTGGGAC	0.433													103	45	---	---	---	---	PASS
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	G	G			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr9:20414343A>G	uc003zoe.2	-	5	760	c.501T>C	c.(499-501)AGT>AGC	p.S167S	MLLT3_uc011lne.1_Silent_p.S135S|MLLT3_uc011lnf.1_Silent_p.S164S|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Missense_Mutation_p.V129A	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.139			T	MLL	ALL								3	35	---	---	---	---	PASS
SYK	6850	broad.mit.edu	37	9	93639979	93639979	+	Silent	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr9:93639979C>T	uc004aqz.2	+	10	1513	c.1308C>T	c.(1306-1308)ATC>ATT	p.I436I	SYK_uc004ara.2_Silent_p.I413I|SYK_uc004arb.2_Silent_p.I413I|SYK_uc004arc.2_Silent_p.I436I|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	436	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						TGCGGATGATCGGGATATGCG	0.502			T	ETV6|ITK	MDS|peripheral T-cell lymphoma								14	77	---	---	---	---	PASS
HSPA5	3309	broad.mit.edu	37	9	128001281	128001281	+	Missense_Mutation	SNP	A	G	G			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr9:128001281A>G	uc004bpn.2	-	5	1191	c.935T>C	c.(934-936)TTC>TCC	p.F312S		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	312					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)	TCCTTCATAGAAGGACTCAAT	0.458										Prostate(1;0.17)			21	59	---	---	---	---	PASS
OBP2A	29991	broad.mit.edu	37	9	138439807	138439807	+	Missense_Mutation	SNP	G	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr9:138439807G>A	uc004cgb.2	+	4	410	c.368G>A	c.(367-369)CGC>CAC	p.R123H	OBP2A_uc004cgc.2_Missense_Mutation_p.R123H|OBP2A_uc010nau.2_RNA|OBP2A_uc010nav.2_Silent_p.A78A	NM_014582	NP_055397	Q9NY56	OBP2A_HUMAN	odorant binding protein 2A precursor	123					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		GGGGGCCTGCGCTACATGGGA	0.617													9	45	---	---	---	---	PASS
USP54	159195	broad.mit.edu	37	10	75276561	75276561	+	Missense_Mutation	SNP	A	G	G			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr10:75276561A>G	uc001juo.2	-	18	3640	c.3623T>C	c.(3622-3624)CTT>CCT	p.L1208P	USP54_uc010qkk.1_Missense_Mutation_p.L390P|USP54_uc001juk.2_Missense_Mutation_p.L296P|USP54_uc001jul.2_Missense_Mutation_p.L296P|USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	1208					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					GTTTAAGGCAAGAGAAGAATG	0.522													25	181	---	---	---	---	PASS
USP54	159195	broad.mit.edu	37	10	75286428	75286428	+	Missense_Mutation	SNP	C	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr10:75286428C>A	uc001juo.2	-	14	2188	c.2171G>T	c.(2170-2172)TGG>TTG	p.W724L	USP54_uc010qkk.1_5'Flank|USP54_uc001juk.2_5'UTR|USP54_uc001jul.2_5'UTR|USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA|USP54_uc001jup.2_Missense_Mutation_p.W724L	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	724					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					ACTCTTTGTCCAGCCACCCAT	0.517													4	116	---	---	---	---	PASS
SORCS3	22986	broad.mit.edu	37	10	106927088	106927088	+	Missense_Mutation	SNP	C	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr10:106927088C>A	uc001kyi.1	+	13	2109	c.1882C>A	c.(1882-1884)CTG>ATG	p.L628M		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	628	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ACACACACCTCTGCCAGTCAG	0.423													4	89	---	---	---	---	PASS
MUC5B	727897	broad.mit.edu	37	11	1264911	1264911	+	Silent	SNP	T	C	C			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr11:1264911T>C	uc009ycr.1	+	48	8841	c.8715T>C	c.(8713-8715)TCT>TCC	p.S2905S	MUC5B_uc001ltb.2_Silent_p.S2270S	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2267	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CACCCCCTTCTCCAGGGACGA	0.677													3	80	---	---	---	---	PASS
SPRYD5	84767	broad.mit.edu	37	11	55653687	55653687	+	Missense_Mutation	SNP	G	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr11:55653687G>T	uc010rip.1	+	3	592	c.500G>T	c.(499-501)TGC>TTC	p.C167F	SPRYD5_uc010riq.1_Missense_Mutation_p.C24F	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	167						intracellular	zinc ion binding				0		all_epithelial(135;0.226)				AGAACCAGATGCTGGAAGGTT	0.398													5	59	---	---	---	---	PASS
PAK1	5058	broad.mit.edu	37	11	77047173	77047173	+	Missense_Mutation	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr11:77047173C>T	uc001oyh.3	-	13	1904	c.1371G>A	c.(1369-1371)ATG>ATA	p.M457I	PAK1_uc010rso.1_Missense_Mutation_p.M359I|PAK1_uc001oyg.3_Missense_Mutation_p.M457I|PAK1_uc001oyi.1_Missense_Mutation_p.M457I|PAK1_uc010rsn.1_Missense_Mutation_p.M170I	NM_002576	NP_002567	Q13153	PAK1_HUMAN	p21-activated kinase 1 isoform 2	457	Protein kinase.				apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			skin(2)|stomach(1)|lung(1)	4	all_cancers(14;1.75e-18)					CCCCTTCAATCATTTCGATGG	0.498													9	100	---	---	---	---	PASS
CASP5	838	broad.mit.edu	37	11	104871149	104871149	+	Missense_Mutation	SNP	A	G	G			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr11:104871149A>G	uc010rva.1	-	6	823	c.791T>C	c.(790-792)CTC>CCC	p.L264P	CASP5_uc010ruz.1_Missense_Mutation_p.L277P|CASP5_uc010rvb.1_Missense_Mutation_p.L206P|CASP5_uc010rvc.1_Missense_Mutation_p.L122P|CASP5_uc009yxh.2_Missense_Mutation_p.L46P|CASP5_uc010rvd.1_Missense_Mutation_p.L46P	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	264					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		ATGAGACATGAGTACCAAGAA	0.458													3	106	---	---	---	---	PASS
NRIP2	83714	broad.mit.edu	37	12	2939920	2939920	+	Missense_Mutation	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr12:2939920C>T	uc001qlc.2	-	2	521	c.449G>A	c.(448-450)AGG>AAG	p.R150K	NRIP2_uc010sed.1_Missense_Mutation_p.R150K	NM_031474	NP_113662	Q9BQI9	NRIP2_HUMAN	nuclear receptor interacting protein 2	150					proteolysis|transcription, DNA-dependent	cytoplasm|nucleus	aspartic-type endopeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GCTGGTCTTCCTCCTGCTCTC	0.572													11	40	---	---	---	---	PASS
ETNK1	55500	broad.mit.edu	37	12	22812066	22812066	+	Missense_Mutation	SNP	G	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr12:22812066G>A	uc001rft.2	+	3	824	c.802G>A	c.(802-804)GCA>ACA	p.A268T	ETNK1_uc009ziz.2_Missense_Mutation_p.A268T	NM_018638	NP_061108	Q9HBU6	EKI1_HUMAN	ethanolamine kinase 1 isoform A	268					phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity				0						CACAGGATTTGCAGATGAAGA	0.328													9	66	---	---	---	---	PASS
ETNK1	55500	broad.mit.edu	37	12	22812075	22812075	+	Missense_Mutation	SNP	G	C	C			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr12:22812075G>C	uc001rft.2	+	3	833	c.811G>C	c.(811-813)GAC>CAC	p.D271H	ETNK1_uc009ziz.2_Missense_Mutation_p.D271H	NM_018638	NP_061108	Q9HBU6	EKI1_HUMAN	ethanolamine kinase 1 isoform A	271					phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity				0						TGCAGATGAAGACATTAATAA	0.328													10	62	---	---	---	---	PASS
SLITRK1	114798	broad.mit.edu	37	13	84455475	84455475	+	Silent	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr13:84455475C>T	uc001vlk.2	-	1	1054	c.168G>A	c.(166-168)CCG>CCA	p.P56P		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	56	LRRNT.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		ACTGGGAAGTCGGGGCAGTGA	0.438													14	89	---	---	---	---	PASS
MYH7	4625	broad.mit.edu	37	14	23890182	23890182	+	Missense_Mutation	SNP	C	G	G			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr14:23890182C>G	uc001wjx.2	-	26	3427	c.3321G>C	c.(3319-3321)AAG>AAC	p.K1107N	MIR208B_hsa-mir-208b|MI0005570_5'Flank	NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1107	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCTCCTTGAGCTTCTTCTGCA	0.582													15	83	---	---	---	---	PASS
PLEKHH1	57475	broad.mit.edu	37	14	68050582	68050582	+	Missense_Mutation	SNP	C	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr14:68050582C>A	uc001xjl.1	+	25	3693	c.3551C>A	c.(3550-3552)GCC>GAC	p.A1184D	PLEKHH1_uc010tsw.1_Missense_Mutation_p.A752D|PLEKHH1_uc001xjn.1_Missense_Mutation_p.A699D|PLEKHH1_uc010tsx.1_Missense_Mutation_p.A49D|PLEKHH1_uc001xjo.1_Missense_Mutation_p.A49D|PLEKHH1_uc001xjp.1_Missense_Mutation_p.A49D	NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	1184	FERM.					cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		AGACATGGGGCCCCCGCTGAA	0.607											OREG0022749	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	31	---	---	---	---	PASS
UBR7	55148	broad.mit.edu	37	14	93677049	93677049	+	Missense_Mutation	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr14:93677049C>T	uc001ybm.3	+	3	576	c.340C>T	c.(340-342)CTT>TTT	p.L114F	UBR7_uc001ybn.3_Missense_Mutation_p.L38F|UBR7_uc010auq.2_5'UTR	NM_175748	NP_786924	Q8N806	UBR7_HUMAN	ubiquitin protein ligase E3 component n-recognin	114	UBR-type.						ubiquitin-protein ligase activity|zinc ion binding				0						ATGCAAATTACTTCCTGTAAG	0.289													4	22	---	---	---	---	PASS
SERPINA13	388007	broad.mit.edu	37	14	95107688	95107688	+	Missense_Mutation	SNP	G	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr14:95107688G>T	uc001ydt.2	+	2	293	c.205G>T	c.(205-207)GTG>TTG	p.V69L		NR_015340				RecName: Full=Serpin A13; Flags: Precursor;											lung(1)|skin(1)	2						GCTGGTCACTGTGCTCATGGC	0.587													6	36	---	---	---	---	PASS
MYLPF	29895	broad.mit.edu	37	16	30387745	30387745	+	Silent	SNP	C	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr16:30387745C>A	uc002dxv.1	+	4	230	c.174C>A	c.(172-174)GGC>GGA	p.G58G		NM_013292	NP_037424	Q96A32	MLRS_HUMAN	myosin light chain, phosphorylatable, fast	58	EF-hand 1.				skeletal muscle tissue development	muscle myosin complex	calcium ion binding|structural constituent of muscle				0			Colorectal(24;0.193)			CCCCTCCAGGCCGCCTCAATG	0.507													7	70	---	---	---	---	PASS
PDP2	57546	broad.mit.edu	37	16	66918200	66918200	+	Missense_Mutation	SNP	G	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr16:66918200G>T	uc002eqk.1	+	2	175	c.13G>T	c.(13-15)GTG>TTG	p.V5L		NM_020786	NP_065837	Q9P2J9	PDP2_HUMAN	pyruvate dehydrogenase phosphatase isoenzyme 2	5					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|metal ion binding			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		GTCAAGTACTGTGTCCTACTG	0.328													9	148	---	---	---	---	PASS
CES8	283848	broad.mit.edu	37	16	67039259	67039259	+	Missense_Mutation	SNP	C	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr16:67039259C>A	uc002eqv.2	+	10	1240	c.1197C>A	c.(1195-1197)TTC>TTA	p.F399L	CES8_uc010vix.1_Missense_Mutation_p.F426L|CES8_uc002eqw.2_Missense_Mutation_p.F399L|CES8_uc002eqy.2_Missense_Mutation_p.F328L|CES8_uc002eqx.2_Missense_Mutation_p.F232L|CES8_uc010viy.1_Missense_Mutation_p.F332L|CES8_uc010viz.1_Missense_Mutation_p.F328L|CES8_uc002eqz.2_5'Flank	NM_173815	NP_776176	Q5XG92	EST4A_HUMAN	carboxylesterase 8 (putative)	426						extracellular region	carboxylesterase activity				0						ATGCCACTTTCGTGTATGCCA	0.532													4	69	---	---	---	---	PASS
LDHD	197257	broad.mit.edu	37	16	75146331	75146331	+	Missense_Mutation	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr16:75146331C>T	uc002fdm.2	-	11	1494	c.1447G>A	c.(1447-1449)GTG>ATG	p.V483M	LDHD_uc002fdn.2_Missense_Mutation_p.V460M	NM_153486	NP_705690	Q86WU2	LDHD_HUMAN	D-lactate dehydrogenase isoform 1 precursor	483							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding				0						TCCACGCCCACGGCGCCCACC	0.662													4	36	---	---	---	---	PASS
MNT	4335	broad.mit.edu	37	17	2298341	2298341	+	Missense_Mutation	SNP	C	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr17:2298341C>A	uc002fur.2	-	2	733	c.481G>T	c.(481-483)GGC>TGC	p.G161C		NM_020310	NP_064706	Q99583	MNT_HUMAN	MAX binding protein	161					multicellular organismal development|negative regulation of cell proliferation|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			skin(1)	1				Colorectal(2;1.37e-05)|READ - Rectum adenocarcinoma(2;8.68e-05)		TTGGGGCTGCCATTGGGTGGA	0.697													3	16	---	---	---	---	PASS
TOP3A	7156	broad.mit.edu	37	17	18210214	18210214	+	Silent	SNP	T	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr17:18210214T>A	uc002gsx.1	-	4	610	c.381A>T	c.(379-381)GTA>GTT	p.V127V	TOP3A_uc002gsw.1_5'UTR|TOP3A_uc010vxs.1_Silent_p.V25V|TOP3A_uc010cqa.1_RNA	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	127	Toprim.				DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						CCTTGATGTCTACAAAATTCT	0.408													6	44	---	---	---	---	PASS
KIAA0100	9703	broad.mit.edu	37	17	26964040	26964040	+	Silent	SNP	T	C	C			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr17:26964040T>C	uc002hbu.2	-	15	2019	c.1920A>G	c.(1918-1920)CCA>CCG	p.P640P		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	640						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					GGCTGAGCACTGGGGTAGGGA	0.547													9	98	---	---	---	---	PASS
NF1	4763	broad.mit.edu	37	17	29665757	29665757	+	Nonsense_Mutation	SNP	C	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr17:29665757C>A	uc002hgg.2	+	46	7188	c.6855C>A	c.(6853-6855)TAC>TAA	p.Y2285*	NF1_uc002hgh.2_Nonsense_Mutation_p.Y2264*|NF1_uc010cso.2_Nonsense_Mutation_p.Y473*|NF1_uc010wbt.1_Intron|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2285					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.Y2285fs*5(4)|p.Y2285*(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CTGACACTTACAACAGTCAAG	0.308			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			20	117	---	---	---	---	PASS
TMEM106A	113277	broad.mit.edu	37	17	41368482	41368482	+	Silent	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr17:41368482C>T	uc002idn.1	+	6	681	c.444C>T	c.(442-444)ATC>ATT	p.I148I	TMEM106A_uc010why.1_Silent_p.I100I|TMEM106A_uc010cze.1_Silent_p.I148I|TMEM106A_uc010whz.1_Intron	NM_145041	NP_659478	Q96A25	T106A_HUMAN	transmembrane protein 106A	148						integral to membrane					0		Breast(137;0.0164)		BRCA - Breast invasive adenocarcinoma(366;0.0917)		TCTTAAACATCTCCAATGGCA	0.517													50	347	---	---	---	---	PASS
CASKIN2	57513	broad.mit.edu	37	17	73497987	73497987	+	Missense_Mutation	SNP	G	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr17:73497987G>T	uc002joc.2	-	18	3718	c.3168C>A	c.(3166-3168)AGC>AGA	p.S1056R	CASKIN2_uc010wsc.1_Missense_Mutation_p.S974R	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	1056	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCATGGCGGGGCTGGGAGCAA	0.677													38	121	---	---	---	---	PASS
C19orf26	255057	broad.mit.edu	37	19	1231080	1231080	+	Missense_Mutation	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr19:1231080C>T	uc002lrm.2	-	9	1431	c.1156G>A	c.(1156-1158)GGT>AGT	p.G386S		NM_152769	NP_689982	Q8N350	DOS_HUMAN	downstream of Stk11	414						integral to membrane					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCTAGCACCTCCATCTACT	0.721										HNSCC(14;0.022)			8	23	---	---	---	---	PASS
TSSK6	83983	broad.mit.edu	37	19	19625717	19625717	+	Missense_Mutation	SNP	A	C	C			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr19:19625717A>C	uc002nmr.2	-	1	753	c.520T>G	c.(520-522)TCA>GCA	p.S174A	TSSK6_uc002nmq.2_RNA|NDUFA13_uc002nms.2_5'Flank|NDUFA13_uc010xqx.1_5'Flank|NDUFA13_uc010xqy.1_5'Flank	NM_032037	NP_114426	Q9BXA6	TSSK6_HUMAN	testis-specific serine kinase 6	174	Protein kinase.				multicellular organismal development|sperm chromatin condensation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1						TAGGCGGCTGAGCCGCAGTAG	0.662													5	22	---	---	---	---	PASS
ZNF473	25888	broad.mit.edu	37	19	50549917	50549917	+	Silent	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr19:50549917C>T	uc002prn.2	+	5	2454	c.2217C>T	c.(2215-2217)TTC>TTT	p.F739F	ZNF473_uc002prm.2_Silent_p.F739F|ZNF473_uc010ybo.1_Silent_p.F727F	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	739	C2H2-type 16.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		GGAAGGCCTTCGGCCTGAGTG	0.512											OREG0025632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	113	---	---	---	---	PASS
ACTR5	79913	broad.mit.edu	37	20	37400216	37400216	+	Silent	SNP	G	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr20:37400216G>A	uc002xjd.2	+	9	1606	c.1581G>A	c.(1579-1581)TCG>TCA	p.S527S		NM_024855	NP_079131	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog	527					DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding				0		Myeloproliferative disorder(115;0.00878)				AACTTGCCTCGAACCCTGTGC	0.507													30	98	---	---	---	---	PASS
KRTAP10-10	353333	broad.mit.edu	37	21	46057497	46057497	+	Missense_Mutation	SNP	A	G	G	rs377408		TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr21:46057497A>G	uc002zfq.2	+	1	225	c.163A>G	c.(163-165)ACG>GCG	p.T55A	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181688	NP_859016	P60014	KR10A_HUMAN	keratin associated protein 10-10	55	3.|15 X 5 AA repeats of C-C-X(3).					keratin filament					0						CTGCTGCCAGACGGCCTGTGA	0.662													4	79	---	---	---	---	PASS
GNB1L	54584	broad.mit.edu	37	22	19799876	19799876	+	Missense_Mutation	SNP	G	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr22:19799876G>A	uc002zqe.1	-	4	743	c.349C>T	c.(349-351)CGG>TGG	p.R117W	GNB1L_uc002zqd.1_5'UTR|GNB1L_uc002zqf.1_Missense_Mutation_p.R117W	NM_053004	NP_443730	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein	117					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)	1	Colorectal(54;0.0993)					ATGCTGCTCCGGCAGAAGCCC	0.697													10	42	---	---	---	---	PASS
KLHL22	84861	broad.mit.edu	37	22	20819559	20819559	+	Nonsense_Mutation	SNP	G	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr22:20819559G>T	uc002zsl.1	-	4	807	c.698C>A	c.(697-699)TCG>TAG	p.S233*	KLHL22_uc011ahr.1_Nonsense_Mutation_p.S90*|KLHL22_uc002zsm.1_Nonsense_Mutation_p.S233*	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	233					cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CTCGTGCAGCGAGATCTGGTC	0.602													3	34	---	---	---	---	PASS
GNAZ	2781	broad.mit.edu	37	22	23437925	23437925	+	Missense_Mutation	SNP	C	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr22:23437925C>T	uc002zwu.1	+	2	580	c.43C>T	c.(43-45)CGG>TGG	p.R15W	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	15						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		AGCAGCCCGGCGGTCCCGGAG	0.637													8	43	---	---	---	---	PASS
SLC5A4	6527	broad.mit.edu	37	22	32614643	32614643	+	Missense_Mutation	SNP	G	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr22:32614643G>T	uc003ami.2	-	15	1840	c.1838C>A	c.(1837-1839)CCC>CAC	p.P613H		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	613	Cytoplasmic (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						GGTTAGCTTGGGTCCCTTCTG	0.483													5	150	---	---	---	---	PASS
MCF2	4168	broad.mit.edu	37	X	138687052	138687052	+	Missense_Mutation	SNP	G	A	A			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chrX:138687052G>A	uc004fau.2	-	14	1943	c.1649C>T	c.(1648-1650)GCA>GTA	p.A550V	MCF2_uc004fav.2_Missense_Mutation_p.A566V|MCF2_uc011mwl.1_Missense_Mutation_p.A527V|MCF2_uc010nsh.1_Missense_Mutation_p.A550V|MCF2_uc011mwm.1_Missense_Mutation_p.A511V|MCF2_uc011mwn.1_Missense_Mutation_p.A695V|MCF2_uc004faw.2_Missense_Mutation_p.A610V|MCF2_uc011mwo.1_Missense_Mutation_p.A626V	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	550	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					ATATATTTCTGCCATGTTTCC	0.308													14	152	---	---	---	---	PASS
F8	2157	broad.mit.edu	37	X	154189424	154189424	+	Missense_Mutation	SNP	G	T	T			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chrX:154189424G>T	uc004fmt.2	-	10	1634	c.1463C>A	c.(1462-1464)GCA>GAA	p.A488E		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	488	F5/8 type A 2.|Plastocyanin-like 3.		A -> G (in HEMA; moderate).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TGGTCTGCTTGCTTGATTCTT	0.363													10	58	---	---	---	---	PASS
KCNN3	3782	broad.mit.edu	37	1	154842199	154842200	+	In_Frame_Ins	INS	-	GCTGCT	GCTGCT	rs3831942		TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr1:154842199_154842200insGCTGCT	uc001ffp.2	-	1	555_556	c.241_242insAGCAGC	c.(241-243)CCA>CAGCAGCCA	p.80_81insQQ	KCNN3_uc009wox.1_In_Frame_Ins_p.80_81insQQ	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	80_86						integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			GGGATGCGGTGgctgctgctgc	0.347													5	3	---	---	---	---	
KIF26A	26153	broad.mit.edu	37	14	104638211	104638211	+	Frame_Shift_Del	DEL	C	-	-			TCGA-85-6175-01A-11D-1817-08	TCGA-85-6175-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	2ba53bf0-a4e1-4b46-b258-610522aac7ee	4ced20e8-5370-451e-be81-d6a1f6b97a33	g.chr14:104638211delC	uc001yos.3	+	6	1265	c.1265delC	c.(1264-1266)GCCfs	p.A422fs		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	422	Kinesin-motor.				blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CGGCGAGCCGCCACTGCTGCA	0.682													4	2	---	---	---	---