Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	ACHILLES_Lineage_Results_Top_Genes	CGC_CancerGermlineMut	CGC_CancerMolecularGenetics	CGC_CancerSomaticMut	CGC_CancerSyndrome	CGC_Chr	CGC_ChrBand	CGC_GeneID	CGC_Name	CGC_OtherGermlineMut	CGC_TissueType	COSMIC_n_overlapping_mutations	COSMIC_overlapping_mutation_descriptions	ClinVar_ASSEMBLY	ClinVar_HGMD_ID	ClinVar_SYM	ClinVar_TYPE	ClinVar_rs	Ensembl_so_accession	Ensembl_so_term	Familial_Cancer_Genes_Reference	Familial_Cancer_Genes_Synonym	annotation_transcript	bcgsc	broad	build	ccds_id	dbNSFP_1000Gp1_AC	dbNSFP_1000Gp1_AF	dbNSFP_1000Gp1_AFR_AC	dbNSFP_1000Gp1_AFR_AF	dbNSFP_1000Gp1_AMR_AC	dbNSFP_1000Gp1_AMR_AF	dbNSFP_1000Gp1_ASN_AC	dbNSFP_1000Gp1_ASN_AF	dbNSFP_1000Gp1_EUR_AC	dbNSFP_1000Gp1_EUR_AF	dbNSFP_Ancestral_allele	dbNSFP_CADD_phred	dbNSFP_CADD_raw	dbNSFP_CADD_raw_rankscore	dbNSFP_ESP6500_AA_AF	dbNSFP_ESP6500_EA_AF	dbNSFP_Ensembl_geneid	dbNSFP_Ensembl_transcriptid	dbNSFP_FATHMM_pred	dbNSFP_FATHMM_rankscore	dbNSFP_FATHMM_score	dbNSFP_GERP_NR	dbNSFP_GERP_RS	dbNSFP_GERP_RS_rankscore	dbNSFP_Interpro_domain	dbNSFP_LRT_Omega	dbNSFP_LRT_converted_rankscore	dbNSFP_LRT_pred	dbNSFP_LRT_score	dbNSFP_LR_pred	dbNSFP_LR_rankscore	dbNSFP_LR_score	dbNSFP_MutationAssessor_pred	dbNSFP_MutationAssessor_rankscore	dbNSFP_MutationAssessor_score	dbNSFP_MutationTaster_converted_rankscore	dbNSFP_MutationTaster_pred	dbNSFP_MutationTaster_score	dbNSFP_Polyphen2_HDIV_pred	dbNSFP_Polyphen2_HDIV_rankscore	dbNSFP_Polyphen2_HDIV_score	dbNSFP_Polyphen2_HVAR_pred	dbNSFP_Polyphen2_HVAR_rankscore	dbNSFP_Polyphen2_HVAR_score	dbNSFP_RadialSVM_pred	dbNSFP_RadialSVM_rankscore	dbNSFP_RadialSVM_score	dbNSFP_Reliability_index	dbNSFP_SIFT_converted_rankscore	dbNSFP_SIFT_pred	dbNSFP_SIFT_score	dbNSFP_SLR_test_statistic	dbNSFP_SiPhy_29way_logOdds	dbNSFP_SiPhy_29way_logOdds_rankscore	dbNSFP_SiPhy_29way_pi	dbNSFP_UniSNP_ids	dbNSFP_Uniprot_aapos	dbNSFP_Uniprot_acc	dbNSFP_Uniprot_id	dbNSFP_aaalt	dbNSFP_aapos	dbNSFP_aapos_FATHMM	dbNSFP_aapos_SIFT	dbNSFP_aaref	dbNSFP_cds_strand	dbNSFP_codonpos	dbNSFP_folddegenerate	dbNSFP_genename	dbNSFP_hg18_pos1coor	dbNSFP_phastCons100way_vertebrate	dbNSFP_phastCons100way_vertebrate_rankscore	dbNSFP_phastCons46way_placental	dbNSFP_phastCons46way_placental_rankscore	dbNSFP_phastCons46way_primate	dbNSFP_phastCons46way_primate_rankscore	dbNSFP_phyloP100way_vertebrate	dbNSFP_phyloP100way_vertebrate_rankscore	dbNSFP_phyloP46way_placental	dbNSFP_phyloP46way_placental_rankscore	dbNSFP_phyloP46way_primate	dbNSFP_phyloP46way_primate_rankscore	dbNSFP_refcodon	entrez_gene_id	external_id_capture	gencode_transcript_name	gencode_transcript_status	gencode_transcript_tags	gencode_transcript_type	gene_type	havana_transcript	hgsc	igv_bad	ucsc	t_alt_count	t_ref_count	n_alt_count	n_ref_count	validation_judgement_rna	validation_power_rna	validation_tumor_alt_count_rna	validation_tumor_ref_count_rna	validation_normal_alt_count_rna	validation_normal_ref_count_rna	min_val_count_rna	validation_judgement_targeted	validation_power_targeted	validation_tumor_alt_count_targeted	validation_tumor_ref_count_targeted	validation_normal_alt_count_targeted	validation_normal_ref_count_targeted	min_val_count_targeted	validation_judgement_localAssembly	validation_power_localAssembly	t_alt_count_localAssembly	t_ref_count_localAssembly	n_alt_count_localAssembly	n_ref_count_localAssembly	min_val_count_localAssembly	validation_judgement_KRAS	validation_power_KRAS	t_alt_count_KRAS	t_ref_count_KRAS	n_alt_count_KRAS	n_ref_count_KRAS	min_val_count_KRAS	pon_loglike	pon_pass_loglike	localAssembly_detected	ExAC_AN	ExAC_AC	ExAC_LQ	passExAC	SCNA_NA	SCNA_NB	SCNA_q_hat	SCNA_tau	IS_SCNA	purity	ploidy	dna_fraction_in_tumor	CCF_hat	CCF_CI95_low	CCF_CI95_high	CCF_mode	CCF_mean	CCF_median	clonal	CCF_CI_low	CCF_CI_high
CCDC93	54520	broad.mit.edu	37	2	118705727	118705727	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr2:118705727delT	ENST00000376300.2	-	15	1315	c.1178delA	c.(1177-1179)aatfs	p.N393fs	CCDC93_ENST00000319432.5_Frame_Shift_Del_p.N392fs	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93			29					CAGATTTTCATTCATGGCTAC	0.373000																								0							SO:0001589	frameshift_variant			ENST00000376300.2	1	1	hg19	CCDS2121.2																																																																																				TCGA-HZ-A49H-01A-11D-A26I-08	CCDC93-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000129615.1	1	0	0	158	1296	0	131	0	3.332791e-02	0	3	0	131	2	0	0	0	0	0	0		1	1.000000	174	1283	2	131	46	0	0	0	0	0	0		-20.000000	1	1	0	0		1	1	2	3	2.001434	0	0.050000	2	0.061960	0.990000	0.990000	1	1	1.000000	0.990000	1	0.990000	1.000000
PSD	5662	broad.mit.edu	37	10	104170669	104170669	+	Silent	SNP	G	G	A			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr10:104170669G>A	ENST00000020673.5	-	10	2563	c.2037C>T	c.(2035-2037)atC>atT	p.I679I	PSD_ENST00000406432.1_Silent_p.I679I	NM_001270966.1|NM_002779.4	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing			34					CCAGGTTCCCGATGAAGTCCC	0.632000																								0							SO:0001819	synonymous_variant			ENST00000020673.5	1	1	hg19	CCDS31272.1																																																																																				TCGA-HZ-A49H-01A-11D-A26I-08	PSD-004	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000050041.2	1	0	0	30	603	0	112	0	9.917710e-02	0	11	0	112	2		0	0	0	0	0	2	1	1.000000	30	595	0	109	2		0	0	0	0	112	2	-5.423394	1	1	0	0		1	0	1	1	1.998401	0	0.050000	2	0.037487	0.990000	0.990000	1	1	0.999605	0.990000	1	0.990000	1.000000
NAA40	79829	broad.mit.edu	37	11	63720021	63720021	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr11:63720021G>A	ENST00000377793.4	+	5	495	c.394G>A	c.(394-396)Gat>Aat	p.D132N	NAA40_ENST00000539656.1_Intron|NAA40_ENST00000542163.1_Missense_Mutation_p.D111N|NAA40_ENST00000456907.2_Missense_Mutation_p.D92N|NAA40_ENST00000536939.1_3'UTR	NM_024771.2	NP_079047.2	Q86UY6	NAA40_HUMAN	N(alpha)-acetyltransferase 40, NatD catalytic subunit			5					GGAGTGTGGGGATGAAGTCCT	0.582000																								0							SO:0001583	missense			ENST00000377793.4	0	1	hg19	CCDS8053.1	.	.	.	.	.	.	.	.	.	.	G	33	5.219701	0.95139	.	.	ENSG00000110583	ENST00000377793;ENST00000456907;ENST00000542163	T;T;T	0.21932	1.98;1.98;1.98	5.63	5.63	0.86233	GCN5-related N-acetyltransferase (GNAT) domain (2);Acyl-CoA N-acyltransferase (2);	0.044312	0.85682	D	0.000000	T	0.31358	0.0794	L	0.45422	1.42	0.80722	D	1	P;P	0.52577	0.954;0.922	P;P	0.54060	0.741;0.697	T	0.00896	-1.1523	10	0.18276	T	0.48	-14.1974	18.432	0.90628	0.0:0.0:1.0:0.0	.	92;132	B4DU10;Q86UY6	.;NAA40_HUMAN	N	132;92;111	ENSP00000367024:D132N;ENSP00000407578:D92N;ENSP00000442055:D111N	ENSP00000367024:D132N	D	+	1	0	NAA40	63476597	1.000000	0.71417	1.000000	0.80357	0.984000	0.73092	9.514000	0.98013	2.645000	0.89757	0.484000	0.47621	GAT		TCGA-HZ-A49H-01A-11D-A26I-08	NAA40-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000396266.1	0	0	0	8	339	0	54	0	6.638870e-02	0	16	0	54	2	0	0	0	1	0	0	2	1	0.989196	8	336	0	54	2		0	0	0	0	54	2	-3.286392	1	1	121412	5	37	1	1	2	3	2.007870	0	0.050000	2	0.063578	0.990000	0.480000	1	1	0.902118	0.990000	1	0.720000	1.000000
FAT3	120114	broad.mit.edu	37	11	92533399	92533399	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr11:92533399C>T	ENST00000298047.6	+	9	7237	c.7220C>T	c.(7219-7221)gCc>gTc	p.A2407V	FAT3_ENST00000525166.1_Missense_Mutation_p.A2257V|FAT3_ENST00000409404.2_Missense_Mutation_p.A2407V			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3			85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)			AGTGAATTAGCCCCCCGGGGC	0.443000										TCGA Ovarian(4;0.039)														0							SO:0001583	missense			ENST00000298047.6	0	1	hg19		.	.	.	.	.	.	.	.	.	.	C	21.9	4.220431	0.79464	.	.	ENSG00000165323	ENST00000298047;ENST00000409404;ENST00000525166	T;T;T	0.55588	0.51;0.51;0.51	5.86	5.86	0.93980	.	.	.	.	.	T	0.74283	0.3696	M	0.74389	2.26	0.80722	D	1	D	0.89917	1.0	D	0.91635	0.999	T	0.72404	-0.4304	9	0.45353	T	0.12	.	20.1772	0.98182	0.0:1.0:0.0:0.0	.	2407	Q8TDW7-3	.	V	2407;2407;2257	ENSP00000298047:A2407V;ENSP00000387040:A2407V;ENSP00000432586:A2257V	ENSP00000298047:A2407V	A	+	2	0	FAT3	92173047	1.000000	0.71417	1.000000	0.80357	0.998000	0.95712	7.755000	0.85180	2.778000	0.95560	0.655000	0.94253	GCC		TCGA-HZ-A49H-01A-11D-A26I-08	FAT3-201	KNOWN	basic	protein_coding	protein_coding		0	0	0	13	620	1	83		0	0	0	1	83	2		0	0	0	0	0	2	0	0.001734	13	615	2	82	33		0	0	0	1	83	2	-2.395632	0	1	0	0		1	0	1	1	1.998243	0	0.050000	2	0.037487	0.800000	0.450000	1	1	0.802264	0.800000	0	0.610000	1.000000
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	KRAS_deep			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr12:25398284C>A	ENST00000256078.4	-	2	98	c.35G>T	c.(34-36)gGt>gTt	p.G12V	KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000311936.3_Missense_Mutation_p.G12V	NM_033360.2	NP_203524.1	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)		GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		pancreatic, colorectal, lung, thyroid, AML, others				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)		Dom	yes		12	12p12.1	3845	v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog		L, E, M, O	15813	Substitution - Missense(15812)|Deletion - Frameshift(1)						SO:0001583	missense	Familial Cancer Database	Male Turner syndrome, Pterygium Colli syndrome, incl. Noonan-like/Multiple Giant Cell Lesion syndrome; Noonan s. with multiple lentigines/LEOPARD syndrome;CFC, CFCS	ENST00000256078.4	0	1	hg19	CCDS8703.1	.	.	.	.	.	.	.	.	.	.	C	27.2	4.808637	0.90707	.	.	ENSG00000133703	ENST00000311936;ENST00000557334;ENST00000256078;ENST00000556131	T;T;T;T	0.78707	-1.2;-1.2;-1.2;-1.2	5.68	5.68	0.88126	Small GTP-binding protein domain (1);	0.000000	0.85682	D	0.000000	D	0.90373	0.6987	M	0.90650	3.135	0.80722	D	1	D;D	0.76494	0.997;0.999	D;D	0.72625	0.969;0.978	D	0.91773	0.5429	10	0.72032	D	0.01	.	18.3719	0.90409	0.0:1.0:0.0:0.0	.	12;12	P01116-2;P01116	.;RASK_HUMAN	V	12	ENSP00000308495:G12V;ENSP00000452512:G12V;ENSP00000256078:G12V;ENSP00000451856:G12V	ENSP00000256078:G12V	G	-	2	0	KRAS	25289551	1.000000	0.71417	1.000000	0.80357	0.998000	0.95712	7.743000	0.85020	2.668000	0.90789	0.563000	0.77884	GGT		TCGA-HZ-A49H-01A-11D-A26I-08	KRAS-004	KNOWN	not_organism_supported|basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000412232.1	1	0	1	15	98	0	10	1	4.543920e-01	6	5	0	10	2	1	1	70	462	0	415	2	1	0.999904	15	97	0	10	2	1	1	1718	6247	0	10	2	-9.786752	1	1	0	0		1	1	2	3	2.005415	0	0.050000	2	0.062885	0.990000	0.990000	1	1	0.999999	0.990000	1	0.990000	1.000000
CPNE6	9362	broad.mit.edu	37	14	24546432	24546432	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr14:24546432G>A	ENST00000397016.2	+	16	1680	c.1369G>A	c.(1369-1371)Gtg>Atg	p.V457M	CPNE6_ENST00000537691.1_Missense_Mutation_p.V512M|CPNE6_ENST00000216775.2_Missense_Mutation_p.V457M	NM_001280558.1	NP_001267487.1	O95741	CPNE6_HUMAN	copine VI (neuronal)			22					CACTGCTATCGTGCGTGCCTC	0.617000																								0							SO:0001583	missense			ENST00000397016.2	1	1	hg19	CCDS9607.1	.	.	.	.	.	.	.	.	.	.	G	18.19	3.569874	0.65765	.	.	ENSG00000100884	ENST00000537691;ENST00000397016;ENST00000216775	T;T;T	0.31247	1.5;1.5;1.5	5.06	5.06	0.68205	von Willebrand factor, type A (2);Copine (1);	0.000000	0.48286	D	0.000197	T	0.66127	0.2758	M	0.93507	3.425	0.51233	D	0.999918	D;D;D	0.89917	1.0;1.0;1.0	D;D;D	0.91635	0.996;0.998;0.999	T	0.76454	-0.2953	10	0.87932	D	0	-12.3339	15.9207	0.79570	0.0:0.0:1.0:0.0	.	512;282;457	F5GXN1;B3KWK1;O95741	.;.;CPNE6_HUMAN	M	512;457;457	ENSP00000440077:V512M;ENSP00000380211:V457M;ENSP00000216775:V457M	ENSP00000216775:V457M	V	+	1	0	CPNE6	23616272	1.000000	0.71417	0.991000	0.47740	0.208000	0.24298	8.019000	0.88732	2.347000	0.79759	0.467000	0.42956	GTG		TCGA-HZ-A49H-01A-11D-A26I-08	CPNE6-003	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000071869.5	1	0	0	35	354	0	65		0	0	0	0	65	2		0	0	0	0	0	2	1	1.000000	34	348	0	65	2		0	0	0	0	65	2	-20.000000	1	1	0	0		1	1	2	3	2.008487	0	0.050000	2	0.063809	0.990000	0.990000	1	1	1.000000	0.990000	1	0.990000	1.000000
DOT1L	84444	broad.mit.edu	37	19	2210769	2210769	+	Silent	SNP	C	C	T			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr19:2210769C>T	ENST00000398665.3	+	14	1302	c.1266C>T	c.(1264-1266)ccC>ccT	p.P422P	AC004490.1_ENST00000585593.1_RNA	NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase			42		Hepatocellular(1079;0.137)			CTGCGAACCCCGAGCGGAAGC	0.632000																								0							SO:0001819	synonymous_variant			ENST00000398665.3	1	1	hg19	CCDS42460.1	.	.	.	.	.	.	.	.	.	.	C	9.563	1.119008	0.20877	0.0	2.41E-4	ENSG00000104885	ENST00000440640	T	0.43294	0.95	4.84	-1.75	0.08031	.	0.214680	0.38778	N	0.001567	T	0.40719	0.1128	.	.	.	0.80722	D	1	.	.	.	.	.	.	T	0.20806	-1.0264	7	0.44086	T	0.13	-23.3002	6.5387	0.22369	0.0:0.2079:0.1517:0.6404	.	.	.	.	L	209	ENSP00000388276:P209L	ENSP00000388276:P209L	P	+	2	0	DOT1L	2161769	0.013000	0.17824	0.899000	0.35326	0.617000	0.37484	-1.172000	0.03112	-0.107000	0.12088	0.561000	0.74099	CCG		TCGA-HZ-A49H-01A-11D-A26I-08	DOT1L-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000318066.1	1	0	1	75	396	0	87	0	2.493253e-01	0	6	0	87	2		0	0	0	0	0	2	1	1.000000	75	394	0	86	2		0	0	0	0	87	2	-2.780457	1	1	120976	24	44	1	1	2	3	2.007428	0	0.050000	2	0.063347	0.990000	0.990000	1	1	1.000000	0.990000	1	0.990000	1.000000
ZNF284	342909	broad.mit.edu	37	19	44590411	44590411	+	Missense_Mutation	SNP	T	T	G			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr19:44590411T>G	ENST00000421176.3	+	5	996	c.780T>G	c.(778-780)atT>atG	p.I260M	RNU6-902P_ENST00000517212.1_RNA|ZNF223_ENST00000591793.1_3'UTR	NM_001037813.2	NP_001032902.1	Q2VY69	ZN284_HUMAN	zinc finger protein 284			15		Prostate(69;0.0435)			AACCTCATATTTGTGAGGAAT	0.408000																								0							SO:0001583	missense			ENST00000421176.3	1	1	hg19	CCDS46099.1	.	.	.	.	.	.	.	.	.	.	t	12.86	2.064710	0.36470	.	.	ENSG00000186026	ENST00000421176	T	0.17528	2.27	2.59	-5.18	0.02840	Zinc finger, C2H2-like (1);Zinc finger, C2H2 (2);Zinc finger, C2H2-type/integrase, DNA-binding (1);	.	.	.	.	T	0.13500	0.0327	N	0.26162	0.8	0.09310	N	1	P	0.52463	0.953	P	0.50860	0.652	T	0.13098	-1.0522	9	0.72032	D	0.01	.	4.1304	0.10146	0.4782:0.0:0.2078:0.3139	.	260	Q2VY69	ZN284_HUMAN	M	260	ENSP00000411032:I260M	ENSP00000411032:I260M	I	+	3	3	ZNF284	49282251	0.000000	0.05858	0.004000	0.12327	0.189000	0.23516	-4.639000	0.00205	-0.871000	0.04042	0.379000	0.24179	ATT		TCGA-HZ-A49H-01A-11D-A26I-08	ZNF284-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000460473.1	0	0	0	14	585	0	67		0	0	0	0	67	2		0	0	0	0	0	2	1	0.999745	14	581	0	67	2		0	0	0	0	67	2	-11.675770	1	1	0	0		1	1	2	3	2.014309	0	0.050000	2	0.064961	0.990000	0.570000	1	1	0.918239	0.990000	1	0.770000	1.000000
RBM15	64783	broad.mit.edu	37	1	110883698	110883698	+	Silent	SNP	A	A	C			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr1:110883698A>C	ENST00000369784.3	+	1	2571	c.1671A>C	c.(1669-1671)gcA>gcC	p.A557A	RP5-1074L1.1_ENST00000449169.1_RNA|RBM15_ENST00000487146.2_Silent_p.A557A|RBM15_ENST00000602849.1_Silent_p.A557A	NM_022768.4	NP_073605.4	Q96T37	RBM15_HUMAN	RNA binding motif protein 15			3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)			GACATCGGGCACCAGACCCTT	0.532000			T	MKL1	acute megakaryocytic leukemia										Dom	yes		1	1p13	64783	RNA binding motif protein 15		L	0							SO:0001819	synonymous_variant			ENST00000369784.3	1	1	hg19	CCDS822.1																																																																																				TCGA-HZ-A49H-01A-11D-A26I-08	RBM15-001	KNOWN	basic|CCDS	protein_coding	protein_coding	OTTHUMT00000031114.2	0	0	0	10	342	0	59	0	1.050370e-03	0	2	0	59	2		0	0	0	0	0	2	1	0.996896	10	340	0	59	2		0	0	0	0	59	2	-10.493610	1	1	0	0		1	1	2	3	2.006151	0	0.050000	2	0.063116	0.990000	0.630000	1	1	0.958998	0.990000	1	0.900000	1.000000
PADI1	29943	broad.mit.edu	37	1	17570638	17570638	+	Missense_Mutation	SNP	A	A	T			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr1:17570638A>T	ENST00000375471.4	+	16	1984	c.1892A>T	c.(1891-1893)gAt>gTt	p.D631V	PADI1_ENST00000536552.1_Missense_Mutation_p.D102V|PADI1_ENST00000413717.2_Missense_Mutation_p.D146V|PADI1_ENST00000537499.1_Missense_Mutation_p.D188V|PADI1_ENST00000460293.1_3'UTR	NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I			28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		L-Citrulline(DB00155)	ATCTTCATTGATGACTACTTG	0.592000													Esophageal Squamous(80;414 1257 4580 27746 50832)											0							SO:0001583	missense			ENST00000375471.4	1	1	hg19	CCDS178.1	.	.	.	.	.	.	.	.	.	.	A	18.33	3.601209	0.66445	.	.	ENSG00000142623	ENST00000375471;ENST00000537499;ENST00000413717;ENST00000536552	T;T;T;T	0.32988	1.43;1.43;1.43;1.43	5.19	5.19	0.71726	Protein-arginine deiminase, C-terminal (1);	0.055229	0.64402	D	0.000001	T	0.62221	0.2410	M	0.90019	3.08	0.80722	D	1	D;D	0.89917	1.0;1.0	D;D	0.81914	0.995;0.995	T	0.71283	-0.4639	10	0.87932	D	0	-21.0955	13.8958	0.63770	1.0:0.0:0.0:0.0	.	146;631	B4DPX6;Q9ULC6	.;PADI1_HUMAN	V	631;188;146;102	ENSP00000364620:D631V;ENSP00000444032:D188V;ENSP00000396697:D146V;ENSP00000444833:D102V	ENSP00000364620:D631V	D	+	2	0	PADI1	17443225	1.000000	0.71417	0.832000	0.32986	0.445000	0.32107	9.063000	0.93927	1.965000	0.57142	0.459000	0.35465	GAT		TCGA-HZ-A49H-01A-11D-A26I-08	PADI1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000006621.1	0	0	0	12	425	0	81	0	5.400437e-03	0	4	0	81	2		0	0	0	0	0	2	1	0.999052	12	418	0	80	2		0	0	0	0	81	2	-11.302330	1	1	0	0		1	1	2	3	2.006151	0	0.050000	2	0.063116	0.990000	0.640000	1	1	0.957634	0.990000	1	0.890000	1.000000
GRIK3	2899	broad.mit.edu	37	1	37324731	37324731	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr1:37324731C>T	ENST00000373091.3	-	7	1098	c.1082G>A	c.(1081-1083)cGc>cAc	p.R361H	GRIK3_ENST00000462621.1_5'UTR|GRIK3_ENST00000373093.4_Missense_Mutation_p.R361H	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	p.R361H(2)		89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			GTTCATGAAGCGGCCGCCAAA	0.627000																								2	Substitution - Missense(2)						SO:0001583	missense			ENST00000373091.3	1	1	hg19	CCDS416.1	.	.	.	.	.	.	.	.	.	.	C	35	5.578993	0.96565	.	.	ENSG00000163873	ENST00000373091;ENST00000373093	D;D	0.83163	-1.69;-1.69	5.68	5.68	0.88126	Extracellular ligand-binding receptor (1);	0.000000	0.85682	D	0.000000	D	0.89037	0.6601	M	0.71581	2.175	0.80722	D	1	D;D	0.55605	0.972;0.963	P;P	0.55545	0.778;0.703	D	0.88965	0.3396	10	0.54805	T	0.06	.	19.7849	0.96432	0.0:1.0:0.0:0.0	.	361;361	A9Z1Z8;Q13003	.;GRIK3_HUMAN	H	361	ENSP00000362183:R361H;ENSP00000362185:R361H	ENSP00000362183:R361H	R	-	2	0	GRIK3	37097318	1.000000	0.71417	1.000000	0.80357	0.999000	0.98932	5.785000	0.68998	2.671000	0.90904	0.650000	0.86243	CGC		TCGA-HZ-A49H-01A-11D-A26I-08	GRIK3-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000012053.1	1	0	1	83	437	1	108		0	0	0	1	108	2		0	0	0	0	0	2	1	1.000000	82	432	1	108	17		0	0	0	1	108	2	-20.000000	1	1	121412	7	39	1	1	2	3	2.006151	0	0.050000	2	0.063116	0.990000	0.990000	1	1	1.000000	0.990000	1	0.990000	1.000000
DMAP1	55929	broad.mit.edu	37	1	44680450	44680450	+	Silent	SNP	G	G	A			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr1:44680450G>A	ENST00000372289.2	+	3	536	c.273G>A	c.(271-273)aaG>aaA	p.K91K	DMAP1_ENST00000315913.5_Silent_p.K91K|DMAP1_ENST00000361745.6_Silent_p.K91K	NM_019100.4	NP_061973.1	Q9NPF5	DMAP1_HUMAN	DNA methyltransferase 1 associated protein 1			16	Acute lymphoblastic leukemia(166;0.155)				GCTCCAAGAAGGTGCGGCCTT	0.612000																								0							SO:0001819	synonymous_variant			ENST00000372289.2	0	1	hg19	CCDS509.1																																																																																				TCGA-HZ-A49H-01A-11D-A26I-08	DMAP1-003	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000020027.3	0	0	0	10	416	0	85	0	5.223181e-01	0	70	0	85	2		0	0	0	0	0	2	1	0.996921	10	415	0	85	2		0	0	0	0	85	2	-3.799431	1	1	0	0		1	1	2	3	2.006151	0	0.050000	2	0.063116	0.990000	0.520000	1	1	0.912844	0.990000	1	0.750000	1.000000
MOV10L1	54456	broad.mit.edu	37	22	50553049	50553049	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr22:50553049C>T	ENST00000262794.5	+	7	1207	c.1124C>T	c.(1123-1125)cCa>cTa	p.P375L	MOV10L1_ENST00000540615.1_Missense_Mutation_p.P355L|MOV10L1_ENST00000395858.3_Missense_Mutation_p.P375L|MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000545383.1_Missense_Mutation_p.P375L	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10 RISC complex RNA helicase like 1			67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)			GGAATCTCTCCAGGTAGTGGA	0.512000																								0							SO:0001583	missense			ENST00000262794.5	1	1	hg19	CCDS14084.1	.	.	.	.	.	.	.	.	.	.	C	12.23	1.875431	0.33162	.	.	ENSG00000073146	ENST00000545383;ENST00000262794;ENST00000395858;ENST00000540615	D;D;T;D	0.85702	-1.83;-1.83;-1.42;-2.02	6.04	4.84	0.62591	.	0.562070	0.17296	N	0.179461	T	0.80874	0.4707	L	0.54323	1.7	0.80722	D	1	B;P;B;B	0.34724	0.418;0.465;0.335;0.335	B;B;B;B	0.34242	0.075;0.178;0.058;0.08	T	0.75445	-0.3315	10	0.17832	T	0.49	-3.1	13.463	0.61237	0.0:0.9129:0.0:0.0871	.	136;355;375;375	B7Z893;F5H403;A8MXC6;Q9BXT6	.;.;.;M10L1_HUMAN	L	375;375;375;355	ENSP00000438978:P375L;ENSP00000262794:P375L;ENSP00000379199:P375L;ENSP00000438542:P355L	ENSP00000262794:P375L	P	+	2	0	MOV10L1	48895176	0.715000	0.27946	0.641000	0.29422	0.103000	0.19146	1.020000	0.30027	2.873000	0.98535	0.563000	0.77884	CCA		TCGA-HZ-A49H-01A-11D-A26I-08	MOV10L1-001	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000075009.2	0	0	0	9	346	0	43		0	0	0	0	43	2		0	0	0	0	0	2	1	0.994293	9	345	0	43	2		0	0	0	0	43	2	-3.445724	1	1	0	0		1	1	2	3	2.002667	0	0.050000	2	0.062423	0.990000	0.540000	1	1	0.931395	0.990000	1	0.800000	1.000000
BMP2K	55589	broad.mit.edu	37	4	79792163	79792163	+	Missense_Mutation	SNP	G	G	C	rs2114202	byFrequency	TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr4:79792163G>C	ENST00000335016.5	+	11	1624	c.1458G>C	c.(1456-1458)caG>caC	p.Q486H	BMP2K_ENST00000502871.1_Missense_Mutation_p.Q486H	NM_198892.1	NP_942595.1	Q9NSY1	BMP2K_HUMAN	BMP2 inducible kinase			13					agcagcagcagcaccaccacc	0.502000																								0							SO:0001583	missense			ENST00000335016.5	1	0	hg19	CCDS47083.1	41|41	0.018772893772893772|0.018772893772893772	17|17	0.034552845528455285|0.034552845528455285	2|2	0.0055248618784530384|0.0055248618784530384	5|5	0.008741258741258742|0.008741258741258742	17|17	0.022427440633245383|0.022427440633245383	G|G	0.076|0.076	-1.191925|-1.191925	0.01607|0.01607	.|.	.|.	ENSG00000138756|ENSG00000138756	ENST00000502613|ENST00000502871;ENST00000335016;ENST00000264889	.|T;T	.|0.74947	.|0.87;-0.89	.|.	.|.	.|.	.|.	.|2.205680	.|0.02506	.|U	.|0.091026	T|T	0.30727|0.30727	0.0774|0.0774	N|N	0.22421|0.22421	0.69|0.69	0.31708|0.31708	N|N	0.639909|0.639909	.|B;B	.|0.02656	.|0.0;0.0	.|B;B	.|0.01281	.|0.0;0.0	T|T	0.29088|0.29088	-1.0023|-1.0023	4|9	.|0.14252	.|T	.|0.57	.|.	5.0772|5.0772	0.14638|0.14638	0.0:0.6216:0.3784:0.0|0.0:0.6216:0.3784:0.0	rs2114202|rs2114202	.|486;486	.|Q9NSY1;Q4W5H2	.|BMP2K_HUMAN;.	P|H	179|486;486;500	.|ENSP00000421768:Q486H;ENSP00000334836:Q486H	.|ENSP00000264889:Q500H	A|Q	+|+	1|3	0|2	BMP2K|BMP2K	80011187|80011187	0.025000|0.025000	0.19082|0.19082	0.098000|0.098000	0.21074|0.21074	0.021000|0.021000	0.10359|0.10359	-3.148000|-3.148000	0.00583|0.00583	-1.546000|-1.546000	0.01717|0.01717	-1.555000|-1.555000	0.00892|0.00892	GCA|CAG		TCGA-HZ-A49H-01A-11D-A26I-08	BMP2K-201	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding		0	0	1	45	316	0	37	1	5.412537e-01	4	10	0	37	2		0	0	0	0	0	2	1	1.000000	13	226	0	27	2		0	0	0	0	37	2	-0.981362	0	0	0	0		1	1	2	3	2.005335	0	0.050000	2	0.062885	0.990000	0.990000	1	1	1.000000	0.990000	1	0.990000	1.000000
ATP10B	23120	broad.mit.edu	37	5	160034027	160034027	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr5:160034027G>A	ENST00000327245.5	-	19	3751	c.2905C>T	c.(2905-2907)Cca>Tca	p.P969S		NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B			75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		TTGCGGTCTGGCTTCTGTAGT	0.443000																								0							SO:0001583	missense			ENST00000327245.5	1	1	hg19	CCDS43394.1	.	.	.	.	.	.	.	.	.	.	G	7.993	0.753803	0.15778	.	.	ENSG00000118322	ENST00000327245	T	0.05996	3.36	5.05	0.51	0.16983	HAD-like domain (1);	0.350809	0.30742	N	0.008963	T	0.04588	0.0125	L	0.31845	0.965	0.20196	N	0.999925	B	0.30146	0.27	B	0.34931	0.192	T	0.36672	-0.9738	9	.	.	.	.	3.8603	0.08993	0.0801:0.2168:0.4445:0.2586	.	969	O94823	AT10B_HUMAN	S	969	ENSP00000313600:P969S	.	P	-	1	0	ATP10B	159966605	0.572000	0.26668	0.873000	0.34254	0.294000	0.27393	0.461000	0.21940	0.526000	0.28541	-0.302000	0.09304	CCA		TCGA-HZ-A49H-01A-11D-A26I-08	ATP10B-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000374127.1	1	0	1	67	545	0	56	0	9.781551e-02	1	4	0	56	2		0	0	0	0	0	2	1	1.000000	68	541	0	56	2		0	0	0	0	56	2	-19.997180	1	1	0	0		1	0	1	1	1.998932	0	0.050000	2	0.037731	0.990000	0.990000	1	1	1.000000	0.990000	1	0.990000	1.000000
ADAMTS12	81792	broad.mit.edu	37	5	33616037	33616037	+	Missense_Mutation	SNP	T	T	G			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr5:33616037T>G	ENST00000504830.1	-	15	2619	c.2284A>C	c.(2284-2286)Aac>Cac	p.N762H	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.N677H|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12			216					TAGTTCCCGTTCCACTGGATA	0.468000										HNSCC(64;0.19)														0							SO:0001583	missense			ENST00000504830.1	1	1	hg19	CCDS34140.1	.	.	.	.	.	.	.	.	.	.	T	23.6	4.431270	0.83776	.	.	ENSG00000151388	ENST00000504830;ENST00000352040	T;T	0.51817	0.69;0.69	5.51	5.51	0.81932	ADAM-TS Spacer 1 (1);	0.089134	0.85682	D	0.000000	T	0.63920	0.2552	L	0.54323	1.7	0.80722	D	1	D;D	0.89917	1.0;0.975	D;P	0.91635	0.999;0.807	T	0.62821	-0.6773	10	0.40728	T	0.16	.	15.2861	0.73828	0.0:0.0:0.0:1.0	.	677;762	P58397-3;P58397	.;ATS12_HUMAN	H	762;677	ENSP00000422554:N762H;ENSP00000344847:N677H	ENSP00000344847:N677H	N	-	1	0	ADAMTS12	33651794	1.000000	0.71417	1.000000	0.80357	0.927000	0.56198	7.961000	0.87903	2.068000	0.61886	0.459000	0.35465	AAC		TCGA-HZ-A49H-01A-11D-A26I-08	ADAMTS12-002	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000367164.2	0	0	0	18	629	0	93	0	0	0	1	0	93	2		0	0	0	0	0	2	1	0.999981	18	624	0	93	2		0	0	0	0	93	2	-14.982860	1	1	0	0		1	0	1	1	1.998981	0	0.050000	2	0.037731	0.990000	0.660000	1	1	0.946311	0.990000	1	0.850000	1.000000
ADAMTS12	81792	broad.mit.edu	37	5	33616038	33616038	+	Nonsense_Mutation	SNP	C	C	T			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr5:33616038C>T	ENST00000504830.1	-	15	2618	c.2283G>A	c.(2281-2283)tgG>tgA	p.W761*	ADAMTS12_ENST00000352040.3_Nonsense_Mutation_p.W676*|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	p.W761*(1)		216					AGTTCCCGTTCCACTGGATAA	0.468000										HNSCC(64;0.19)														1	Substitution - Nonsense(1)						SO:0001587	stop_gained			ENST00000504830.1	0	1	hg19	CCDS34140.1	.	.	.	.	.	.	.	.	.	.	C	44	10.873556	0.99481	.	.	ENSG00000151388	ENST00000504830;ENST00000352040	.	.	.	5.51	5.51	0.81932	.	0.057874	0.85682	D	0.000000	.	.	.	.	.	.	0.80722	D	1	.	.	.	.	.	.	.	.	.	.	0.59425	D	0.04	.	19.015	0.92890	0.0:1.0:0.0:0.0	.	.	.	.	X	761;676	.	ENSP00000344847:W676X	W	-	3	0	ADAMTS12	33651795	1.000000	0.71417	1.000000	0.80357	0.936000	0.57629	7.741000	0.84997	2.558000	0.86282	0.561000	0.74099	TGG		TCGA-HZ-A49H-01A-11D-A26I-08	ADAMTS12-002	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000367164.2	0	0	0	18	630	0	95	0	0	0	1	0	95	2		0	0	0	0	0	2	1	0.999981	18	625	0	95	2		0	0	0	0	95	2	-3.258301	1	1	0	0		1	0	1	1	1.998981	0	0.050000	2	0.037731	0.990000	0.660000	1	1	0.945889	0.990000	1	0.840000	1.000000
GRM1	2911	broad.mit.edu	37	6	146720262	146720262	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr6:146720262G>A	ENST00000282753.1	+	7	2322	c.2087G>A	c.(2086-2088)cGg>cAg	p.R696Q	GRM1_ENST00000492807.2_Missense_Mutation_p.R696Q|GRM1_ENST00000355289.4_Missense_Mutation_p.R696Q|GRM1_ENST00000507907.1_Missense_Mutation_p.R696Q|GRM1_ENST00000361719.2_Missense_Mutation_p.R696Q|GRM1_ENST00000392299.2_Missense_Mutation_p.R696Q			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1			126		Ovarian(120;0.0387)			ATCTGCACCCGGAAGCCCAGG	0.512000																								0							SO:0001583	missense			ENST00000282753.1	1	1	hg19	CCDS5209.1	.	.	.	.	.	.	.	.	.	.	G	12.70	2.016814	0.35606	.	.	ENSG00000152822	ENST00000361719;ENST00000392299;ENST00000492807;ENST00000282753;ENST00000355289;ENST00000507907	D;D;D;D;D;D	0.87491	-2.26;-2.26;-2.26;-2.26;-2.26;-2.26	5.51	5.51	0.81932	GPCR, family 3, C-terminal (2);	0.000000	0.85682	D	0.000000	D	0.84647	0.5518	L	0.37850	1.14	0.58432	D	0.999998	D;D;D	0.76494	0.997;0.999;0.997	P;D;P	0.64321	0.852;0.924;0.852	T	0.80883	-0.1183	10	0.06365	T	0.9	.	19.4081	0.94656	0.0:0.0:1.0:0.0	.	696;696;696	F8W805;Q13255;Q13255-2	.;GRM1_HUMAN;.	Q	696	ENSP00000354896:R696Q;ENSP00000376119:R696Q;ENSP00000424095:R696Q;ENSP00000282753:R696Q;ENSP00000347437:R696Q;ENSP00000425599:R696Q	ENSP00000282753:R696Q	R	+	2	0	GRM1	146761955	1.000000	0.71417	1.000000	0.80357	0.995000	0.86356	7.876000	0.87215	2.604000	0.88044	0.585000	0.79938	CGG		TCGA-HZ-A49H-01A-11D-A26I-08	GRM1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000042574.1	0	0	0	17	846	0	114		0	0	0	0	114	2		0	0	0	0	0	2	1	0.999961	17	838	0	114	2		0	0	0	0	114	2	-2.193374	0	1	121412	4	41	1	0	1	1	1.991473	0	0.050000	2	0.035778	0.770000	0.460000	1	1	0.778958	0.770000	0	0.600000	0.970000
NRSN1	140767	broad.mit.edu	37	6	24134622	24134622	+	Missense_Mutation	SNP	C	C	T	rs143725119		TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr6:24134622C>T	ENST00000378491.4	+	3	368	c.67C>T	c.(67-69)Cgc>Tgc	p.R23C	NRSN1_ENST00000378478.1_Missense_Mutation_p.R23C|NRSN1_ENST00000378475.1_Missense_Mutation_p.R23C	NM_080723.4	NP_542454.3			neurensin 1			22					TGGTTACCAGCGCTATGGAGT	0.517000																								0							SO:0001583	missense			ENST00000378491.4	1	1	hg19	CCDS4549.1	.	.	.	.	.	.	.	.	.	.	C	25.6	4.652867	0.88056	4.54E-4	0.0	ENSG00000152954	ENST00000378491;ENST00000378478;ENST00000378477;ENST00000378475	T;T;T	0.18338	2.22;2.22;2.22	5.85	5.85	0.93711	.	0.105826	0.64402	D	0.000003	T	0.27663	0.0680	L	0.57536	1.79	0.80722	D	1	D	0.76494	0.999	P	0.56700	0.804	T	0.01004	-1.1484	10	0.87932	D	0	.	20.1634	0.98142	0.0:1.0:0.0:0.0	.	23	Q8IZ57	NRSN1_HUMAN	C	23	ENSP00000367752:R23C;ENSP00000367739:R23C;ENSP00000367736:R23C	ENSP00000367736:R23C	R	+	1	0	NRSN1	24242601	1.000000	0.71417	1.000000	0.80357	0.988000	0.76386	3.736000	0.55052	2.773000	0.95371	0.655000	0.94253	CGC		TCGA-HZ-A49H-01A-11D-A26I-08	NRSN1-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000043866.1	0	0	0	10	313	0	53		0	0	0	0	53	2		0	0	0	0	0	2	1	0.996902	10	311	0	52	2		0	0	0	0	53	2	-10.452130	1	1	121412	5	39	1	1	2	3	2.003946	0	0.050000	2	0.062654	0.990000	0.680000	1	1	0.972313	0.990000	1	0.980000	1.000000
ZBTB22	9278	broad.mit.edu	37	6	33284203	33284203	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr6:33284203G>A	ENST00000431845.2	-	2	642	c.491C>T	c.(490-492)aCc>aTc	p.T164I	TAPBP_ENST00000426633.2_5'Flank|TAPBP_ENST00000434618.2_5'Flank|TAPBP_ENST00000475304.1_5'Flank|TAPBP_ENST00000456592.2_5'Flank|TAPBP_ENST00000489157.1_5'Flank|ZBTB22_ENST00000418724.1_Missense_Mutation_p.T164I	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22			21					AGTGACAGAGGTGGCTGCAGC	0.642000																								0							SO:0001583	missense			ENST00000431845.2	1	1	hg19	CCDS4775.1	.	.	.	.	.	.	.	.	.	.	G	10.31	1.314965	0.23908	.	.	ENSG00000236104	ENST00000418724;ENST00000431845	T;T	0.06142	3.34;3.34	3.53	3.53	0.40419	.	0.500652	0.15013	N	0.285427	T	0.01421	0.0046	N	0.14661	0.345	0.26247	N	0.978772	B	0.26975	0.165	B	0.22601	0.04	T	0.46775	-0.9167	10	0.33141	T	0.24	.	10.8007	0.46487	0.0:0.0:1.0:0.0	.	164	O15209	ZBT22_HUMAN	I	164	ENSP00000404403:T164I;ENSP00000407545:T164I	ENSP00000404403:T164I	T	-	2	0	ZBTB22	33392181	0.997000	0.39634	0.997000	0.53966	0.983000	0.72400	0.435000	0.21510	1.990000	0.58119	0.551000	0.68910	ACC		TCGA-HZ-A49H-01A-11D-A26I-08	ZBTB22-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000076183.2	0	0	0	17	584	0	107	0	5.185119e-01	1	58	0	107	2		0	0	0	0	0	2	1	0.999964	17	581	0	106	2		0	0	0	0	107	2	-14.446480	1	1	0	0		1	1	2	3	2.003946	0	0.050000	2	0.062654	0.990000	0.720000	1	1	0.972032	0.990000	1	0.950000	1.000000
CDK5RAP2	55755	broad.mit.edu	37	9	123253652	123253652	+	Missense_Mutation	SNP	A	A	C			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chr9:123253652A>C	ENST00000349780.4	-	13	1594	c.1415T>G	c.(1414-1416)tTg>tGg	p.L472W	CDK5RAP2_ENST00000360190.4_Missense_Mutation_p.L472W|CDK5RAP2_ENST00000360822.3_Missense_Mutation_p.L472W|CDK5RAP2_ENST00000359309.3_Missense_Mutation_p.L472W	NM_018249.4	NP_060719.4	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2			58					TTGATTGTGCAATTTTTTATT	0.318000																								0							SO:0001583	missense			ENST00000349780.4	1	1	hg19	CCDS6823.1	.	.	.	.	.	.	.	.	.	.	A	11.87	1.768643	0.31320	.	.	ENSG00000136861	ENST00000360822;ENST00000359309;ENST00000349780;ENST00000360190;ENST00000345313	T;T;T;T	0.49720	0.77;0.77;0.77;0.77	5.76	4.59	0.56863	.	0.528460	0.15845	N	0.241808	T	0.64778	0.2629	M	0.66939	2.045	0.09310	N	0.999999	D;D;D;D	0.89917	1.0;1.0;0.998;0.999	D;D;D;D	0.68943	0.961;0.961;0.944;0.915	T	0.56998	-0.7886	10	0.66056	D	0.02	.	11.7091	0.51614	0.8524:0.1476:0.0:0.0	.	273;472;472;472	Q6MZT4;Q96SN8-2;Q96SN8-4;Q96SN8	.;.;.;CK5P2_HUMAN	W	472;472;472;472;474	ENSP00000354065:L472W;ENSP00000352258:L472W;ENSP00000343818:L472W;ENSP00000353317:L472W	ENSP00000341695:L474W	L	-	2	0	CDK5RAP2	122293473	0.059000	0.20769	0.001000	0.08648	0.030000	0.12068	3.122000	0.50446	0.969000	0.38237	0.528000	0.53228	TTG		TCGA-HZ-A49H-01A-11D-A26I-08	CDK5RAP2-005	KNOWN	basic|appris_candidate_longest|CCDS	protein_coding	protein_coding	OTTHUMT00000055535.1	1	0	1	36	250	0	31	0	4.613411e-02	0	3	0	31	2		0	0	0	0	0	2	1	1.000000	36	250	0	30	2		0	0	0	0	31	2	-20.000000	1	1	0	0		1	0	1	1	1.999863	0	0.050000	2	0.037975	0.990000	0.990000	1	1	1.000000	0.990000	1	0.990000	1.000000
HS6ST2	90161	broad.mit.edu	37	X	131762528	131762528	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chrX:131762528C>T	ENST00000370836.2	-	4	1956	c.1541G>A	c.(1540-1542)cGt>cAt	p.R514H	HS6ST2_ENST00000521489.1_Missense_Mutation_p.R554H|HS6ST2_ENST00000406696.3_Missense_Mutation_p.R240H|HS6ST2_ENST00000370833.2_Missense_Mutation_p.R408H	NM_147175.3	NP_671704.3	Q96MM7	H6ST2_HUMAN	heparan sulfate 6-O-sulfotransferase 2			9	Acute lymphoblastic leukemia(192;0.000127)				TTGTTCCTGACGCTTTCGCCT	0.483000																								0							SO:0001583	missense			ENST00000370836.2	0	1	hg19	CCDS48169.1	0	0.0	0	0.0	0	0.0	0	0.0	0	0.0	C	17.93	3.508910	0.64410	.	.	ENSG00000171004	ENST00000370837;ENST00000370836;ENST00000521489;ENST00000406696;ENST00000370833	T;T;T;T;T	0.81330	-1.4;-0.86;-0.77;-1.48;-1.25	6.01	4.25	0.50352	.	0.000000	0.85682	D	0.000000	T	0.70185	0.3195	L	0.54323	1.7	0.45899	D	0.998743	P;P;B	0.43231	0.801;0.801;0.019	B;B;B	0.27500	0.08;0.08;0.004	T	0.69960	-0.5003	10	0.72032	D	0.01	-3.7585	10.293	0.43608	0.0:0.7937:0.1322:0.0742	.	514;554;240	Q96MM7;E9PDY5;B7Z5H6	H6ST2_HUMAN;.;.	H	368;514;554;240;408	ENSP00000359874:R368H;ENSP00000359873:R514H;ENSP00000429473:R554H;ENSP00000384013:R240H;ENSP00000359870:R408H	ENSP00000359870:R408H	R	-	2	0	HS6ST2	131590209	1.000000	0.71417	1.000000	0.80357	0.959000	0.62525	6.070000	0.71220	0.665000	0.31066	0.594000	0.82650	CGT		TCGA-HZ-A49H-01A-11D-A26I-08	HS6ST2-002	KNOWN	basic|appris_candidate|CCDS	protein_coding	protein_coding	OTTHUMT00000058332.3	0	0	0	15	715	0	80	0	0	0	1	0	80	2		0	0	0	0	0	2	1	0.999865	14	712	0	80	2		0	0	0	0	80	2	-11.118570	1	1	120900	14	42	1	0	1	1			0.050000	2	0.050000	0.820000	0.480000	1	1	0.818909	0.820000	0	0.630000	1.000000
FAM47A	158724	broad.mit.edu	37	X	34149477	34149477	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-A49H-01A-11D-A26I-08	TCGA-HZ-A49H-10A-01D-A26I-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	23635060-618f-4272-9a34-284c65318d9a	27fb1352-19ad-417f-acbe-a2af1c099544	g.chrX:34149477C>T	ENST00000346193.3	-	1	970	c.919G>A	c.(919-921)Gag>Aag	p.E307K		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A			97					AGTGGAGTCTCGAAAGGCCGA	0.612000																								0							SO:0001583	missense			ENST00000346193.3	1	1	hg19	CCDS43926.1	.	.	.	.	.	.	.	.	.	.	c	9.037	0.988840	0.18966	.	.	ENSG00000185448	ENST00000346193	T	0.19806	2.12	0.13	0.13	0.14746	.	.	.	.	.	T	0.11367	0.0277	L	0.52126	1.63	0.09310	N	1	P	0.49253	0.921	B	0.29353	0.101	T	0.30060	-0.9991	8	0.16896	T	0.51	.	.	.	.	.	307	Q5JRC9	FA47A_HUMAN	K	307	ENSP00000345029:E307K	ENSP00000345029:E307K	E	-	1	0	FAM47A	34059398	0.730000	0.28100	0.064000	0.19789	0.064000	0.16182	0.440000	0.21592	0.171000	0.19730	0.173000	0.16961	GAG		TCGA-HZ-A49H-01A-11D-A26I-08	FAM47A-001	KNOWN	basic|appris_principal|CCDS	protein_coding	protein_coding	OTTHUMT00000056205.1	1	0	1	36	197	0	36		0	0	0	0	36	2		0	0	0	0	0	2	1	1.000000	36	196	0	34	2		0	0	0	0	36	2	-20.000000	1	1	121366	1	32	1	0	1	1			0.050000	2	0.050000	0.990000	0.990000	1	1	1.000000	0.990000	1	0.990000	1.000000