Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KAT6A	7994	broad.mit.edu	37	8	41790659	41790659	+	Silent	SNP	T	T	G			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr8:41790659T>G	ENST00000396930.3	-	18	5622	c.5079A>C	c.(5077-5079)ccA>ccC	p.P1693P	KAT6A_ENST00000265713.2_Silent_p.P1693P|KAT6A_ENST00000406337.1_Silent_p.P1693P	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	1693	Gln/Pro-rich.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										ggggagggggtgggggtggag	0.627000													11	146					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58563985	58563985	+	Silent	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:58563985G>A	ENST00000348616.4	+	9	1350	c.1050G>A	c.(1048-1050)gcG>gcA	p.A350A	CDH26_ENST00000244047.5_Silent_p.A350A	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	350	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CTCGCCCAGCGCAAAGCCTCA	0.572000													5	376					0	0	1	0	0
BTN2A3P	0	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													5	303					0	0	1	0	0
ESYT1	23344	broad.mit.edu	37	12	56525276	56525276	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:56525276C>T	ENST00000394048.5	+	6	994	c.730C>T	c.(730-732)Cgg>Tgg	p.R244W	ESYT1_ENST00000541590.1_Missense_Mutation_p.R244W|ESYT1_ENST00000267113.4_Missense_Mutation_p.R244W	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	244						integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						TGGCGTTTTGCGGGTGATACT	0.517000													9	1544					0	0	1	0	0
FBXO46	23403	broad.mit.edu	37	19	46215179	46215179	+	Silent	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr19:46215179G>A	ENST00000317683.3	-	2	1708	c.1575C>T	c.(1573-1575)taC>taT	p.Y525Y		NM_001080469.1	NP_001073938.1	Q6PJ61	FBX46_HUMAN	F-box protein 46	525							protein binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(2)|skin(1)	15		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		GATCATCGCGGTAGAGCGGGT	0.647000													4	192					0	0	1	0	0
RNF216	54476	broad.mit.edu	37	7	5754712	5754712	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr7:5754712G>A	ENST00000425013.2	-	11	1858	c.1634C>T	c.(1633-1635)gCc>gTc	p.A545V	RNF216_ENST00000389902.3_Missense_Mutation_p.A602V	NM_207111.3|NM_207116.2	NP_996994.1|NP_996999.1	Q9NWF9	RN216_HUMAN	ring finger protein 216	545					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding		FBXL18/RNF216(2)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|urinary_tract(4)	33		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		TGCCTCTTGGGCATATCTGAT	0.463000													6	697					0	0	1	0	0
ZNF692	55657	broad.mit.edu	37	1	249150605	249150605	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr1:249150605G>A	ENST00000451251.1	-	6	901	c.556C>T	c.(556-558)Cca>Tca	p.P186S	ZNF692_ENST00000468455.1_5'UTR|ZNF692_ENST00000366469.5_Missense_Mutation_p.P181S|ZNF692_ENST00000427146.1_Intron|ZNF692_ENST00000306601.4_Missense_Mutation_p.P181S|ZNF692_ENST00000366471.3_Intron	NM_001136036.2	NP_001129508.1	Q9BU19	ZN692_HUMAN	zinc finger protein 692	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)	17	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			AAGGTCTCTGGTGGGGGTCCC	0.557000													42	48					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													6	164					0	0	1	0	0
DPY19L2P2	0	broad.mit.edu	37	7	102916042	102916042	+	RNA	SNP	T	T	C			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr7:102916042T>C	ENST00000312132.4	-	0	737																											AGAGAAATGATGATCATTTTC	0.284000													4	153					0	0	1	0	0
GALNT18	374378	broad.mit.edu	37	11	11354301	11354301	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr11:11354301C>A	ENST00000227756.4	-	8	1767	c.1356G>T	c.(1354-1356)tgG>tgT	p.W452C		NM_198516.2	NP_940918.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18																		TGACCAGGTACCACCGGAAGG	0.542000													94	92					2.0191e-50	2.18864e-50	1	1	0
DCP1B	196513	broad.mit.edu	37	12	2062350	2062350	+	Missense_Mutation	SNP	C	C	G			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:2062350C>G	ENST00000280665.6	-	7	835	c.756G>C	c.(754-756)caG>caC	p.Q252H	DCP1B_ENST00000397173.4_Missense_Mutation_p.Q150H|DCP1B_ENST00000541700.1_5'UTR|DCP1B_ENST00000540622.1_Missense_Mutation_p.Q126H	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	252	Poly-Gln.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding	p.Q252H(8)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			gctgctgctgctgGTGGAGAG	0.552000													7	227					0	0	1	0	0
RNF181	51255	broad.mit.edu	37	2	85822895	85822895	+	Silent	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr2:85822895C>T	ENST00000441634.1	+	1	48	c.9C>T	c.(7-9)tcC>tcT	p.S3S	RNF181_ENST00000306368.4_Silent_p.S3S			Q9P0P0	RN181_HUMAN	ring finger protein 181	3							ligase activity|zinc ion binding			lung(1)|stomach(1)	2						CCATGGCGTCCTATTTCGATG	0.637000													39	56					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102304884	102304884	+	RNA	SNP	G	G	C	rs143982735	by1000genomes	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr15:102304884G>C	ENST00000561463.1	+	0	12930																											GCGTGGGAACGAGAAGACACT	0.562000													3	71					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134072496	134072496	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr4:134072496G>A	ENST00000264360.4	+	1	2027	c.1201G>A	c.(1201-1203)Gtg>Atg	p.V401M		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	401	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ACTGGGAGACGTGCCTTTCCG	0.607000													7	1025					0	0	1	0	0
SNAP47	116841	broad.mit.edu	37	1	227935771	227935771	+	Missense_Mutation	SNP	G	G	A	rs140772937		TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr1:227935771G>A	ENST00000366759.4	+	2	883	c.469G>A	c.(469-471)Gca>Aca	p.A157T	SNAP47_ENST00000366760.1_Intron|SNAP47_ENST00000315781.5_Missense_Mutation_p.A157T	NM_053052.3	NP_444280.2	Q5SQN1	SNP47_HUMAN	synaptosomal-associated protein, 47kDa	157	t-SNARE coiled-coil homology 1.					endomembrane system|membrane|perinuclear region of cytoplasm				endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17						CGTGGCAGACGCATCTGTCCC	0.632000													93	78					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45522763	45522763	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr21:45522763C>T	ENST00000291574.4	+	22	3626	c.3451C>T	c.(3451-3453)Ccg>Tcg	p.P1151S		NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	1151					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						GGAAGTGATGCCGCTCTTCGC	0.592000													5	473					0	0	1	0	0
DAXX	1616	broad.mit.edu	37	6	33287900	33287900	+	Silent	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr6:33287900C>T	ENST00000374542.5	-	5	1557	c.1353G>A	c.(1351-1353)gaG>gaA	p.E451E	DAXX_ENST00000477162.1_5'UTR|DAXX_ENST00000266000.6_Silent_p.E451E|DAXX_ENST00000414083.2_Silent_p.E376E	NM_001141969.1|NM_001141970.1|NM_001350.4	NP_001135441.1|NP_001135442.1|NP_001341.1	Q9UER7	DAXX_HUMAN	death-domain associated protein	451	Asp/Glu-rich (acidic).|Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding	p.E451E(2)		breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(2)|lung(7)|ovary(3)|pancreas(18)|prostate(3)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	55						cttcttcttcctcctcctcct	0.557000			"""Mis, F, N"""		Pancreatic neuroendocrine tumors. Paediatric GBM								4	138					0	0	1	0	0
IGKV1D-8	0	broad.mit.edu	37	2	90259784	90259784	+	RNA	SNP	G	G	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr2:90259784G>T	ENST00000471857.1	+	0	192																											ATGGACATGAGGGTCCCCGCT	0.552000													6	686					1.5842e-08	1.65409e-08	1	1	0
FRG1B	0	broad.mit.edu	37	20	29625941	29625941	+	Missense_Mutation	SNP	A	A	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:29625941A>T	ENST00000278882.3	+	5	565	c.185A>T	c.(184-186)gAt>gTt	p.D62V	FRG1B_ENST00000358464.4_Missense_Mutation_p.D62V|FRG1B_ENST00000439954.2_Missense_Mutation_p.D67V														p.D62V(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGCATTCAGATGCAATTGGA	0.333000													24	519					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42356192	42356192	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr14:42356192C>T	ENST00000554171.1	+	5	2796	c.364C>T	c.(364-366)Ctt>Ttt	p.L122F	LRFN5_ENST00000298119.4_Missense_Mutation_p.L122F|LRFN5_ENST00000554120.1_Missense_Mutation_p.L122F			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	122						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GTTCAGTGGTCTTTCCAATCT	0.383000										HNSCC(30;0.082)			8	374					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S|FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													6	523					0	0	1	0	0
FOLH1	2346	broad.mit.edu	37	11	49186293	49186293	+	Silent	SNP	C	C	T	rs141224157	by1000genomes	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr11:49186293C>T	ENST00000340334.7	-	14	1727	c.1359G>A	c.(1357-1359)ccG>ccA	p.P453P	FOLH1_ENST00000256999.2_Silent_p.P468P|FOLH1_ENST00000533034.1_Silent_p.P453P|FOLH1_ENST00000356696.3_Silent_p.P468P|FOLH1_ENST00000343844.4_Silent_p.P160P|FOLH1_ENST00000525629.1_5'UTR	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	468	NAALADase.				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TGTACATCAGCGGTGTACAAT	0.284000													4	205					0	0	1	0	0
RP11-119F19.2	0	broad.mit.edu	37	10	81443781	81443781	+	RNA	SNP	A	A	T	rs143569743	by1000genomes	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr10:81443781A>T	ENST00000600376.1	-	0	54				RP11-119F19.2_ENST00000596088.1_RNA																							GACCACAAAGACGAGGAGGAG	0.622000													4	68					0	0	1	0	0
PSPC1	55269	broad.mit.edu	37	13	20356758	20356758	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr13:20356758G>A	ENST00000338910.4	-	1	299	c.140C>T	c.(139-141)cCg>cTg	p.P47L		NM_001042414.2	NP_001035879.1	Q8WXF1	PSPC1_HUMAN	paraspeckle component 1	47					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)		GGGCGCGGGCGGTGCCGGCTC	0.706000													4	159					0	0	1	0	0
DKC1	1736	broad.mit.edu	37	X	153994624	153994624	+	Missense_Mutation	SNP	A	A	G			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chrX:153994624A>G	ENST00000369550.5	+	5	607	c.397A>G	c.(397-399)Atc>Gtc	p.I133V		NM_001142463.1|NM_001363.3	NP_001135935.1|NP_001354.1	O60832	DKC1_HUMAN	dyskeratosis congenita 1, dyskerin	133					cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity			breast(2)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)	15	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGGTTGTTTAATCGTGTGCAT	0.537000									Congenital Dyskeratosis				10	120					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127744367	127744367	+	Splice_Site	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr5:127744367C>T	ENST00000508053.1	-	14	2052	c.1078_splice	c.e14+1	p.D360_splice	FBN2_ENST00000508989.1_Splice_Site_p.D327_splice|FBN2_ENST00000262464.4_Splice_Site_p.D360_splice			P35556	FBN2_HUMAN	fibrillin 2	360					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CGAGGCTTACCGATGCATCGA	0.413000													95	354					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62195959	62195959	+	Missense_Mutation	SNP	T	T	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:62195959T>A	ENST00000467148.1	-	8	4285	c.4216A>T	c.(4216-4218)Atg>Ttg	p.M1406L	HELZ2_ENST00000427522.2_Missense_Mutation_p.M837L	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		GCCGGCAGCATGGGCACTGGC	0.697000													11	24					0	0	1	0	0
FAM53C	51307	broad.mit.edu	37	5	137681216	137681216	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr5:137681216C>T	ENST00000239906.5	+	4	1267	c.839C>T	c.(838-840)gCc>gTc	p.A280V	FAM53C_ENST00000434981.2_Missense_Mutation_p.A280V|FAM53C_ENST00000513056.1_Missense_Mutation_p.P90S	NM_016605.2	NP_057689.1	Q9NYF3	FA53C_HUMAN	family with sequence similarity 53, member C	280										breast(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GATCTGGATGCCCGCAAAACT	0.632000													6	714					0	0	1	0	0
PPP3R2	5535	broad.mit.edu	37	9	104356877	104356877	+	Silent	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr9:104356877G>A	ENST00000374806.1	-	1	406	c.336C>T	c.(334-336)aaC>aaT	p.N112N	GRIN3A_ENST00000361820.3_Intron	NM_147180.2	NP_671709.1	Q96LZ3	CANB2_HUMAN	protein phosphatase 3, regulatory subunit B, beta	109	EF-hand 3.						calcium ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	22		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	AGAGCTCCCCGTTGGAAATGT	0.542000													8	554					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628278	29628278	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:29628278G>A	ENST00000278882.3	+	6	660	c.280G>A	c.(280-282)Gca>Aca	p.A94T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A94T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A99T																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGCAATGAAGCAGGGGACAT	0.373000													14	435					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35706336	35706336	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr9:35706336G>A	ENST00000314888.9	-	40	5571	c.5218C>T	c.(5218-5220)Ccg>Tcg	p.P1740S	TLN1_ENST00000540444.1_Missense_Mutation_p.P1724S|TLN1_ENST00000464379.1_Intron	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	1740	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AGGGTGAGCGGCTCAAAGTAC	0.607000													5	449					0	0	1	0	0
C4orf32	132720	broad.mit.edu	37	4	113107884	113107884	+	Silent	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr4:113107884G>A	ENST00000309733.4	+	2	373	c.189G>A	c.(187-189)ccG>ccA	p.P63P		NM_152400.2	NP_689613.1	Q8N8J7	CD032_HUMAN	chromosome 4 open reading frame 32	63						integral to membrane							Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00198)		CTGGTGAGCCGGTTGGAGATG	0.353000													6	654					0	0	1	0	0
CD300LG	146894	broad.mit.edu	37	17	41924588	41924588	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr17:41924588C>T	ENST00000317310.4	+	1	45	c.4C>T	c.(4-6)Cgg>Tgg	p.R2W	CD300LG_ENST00000377203.4_Missense_Mutation_p.R2W|CD300LG_ENST00000539718.1_Missense_Mutation_p.R2W|CD300LG_ENST00000293396.8_Missense_Mutation_p.R2W|CD300LG_ENST00000588884.1_Missense_Mutation_p.R2W|CD300LG_ENST00000586233.1_Missense_Mutation_p.R2W	NM_145273.3	NP_660316.2	Q6UXG3	CLM9_HUMAN	CD300 molecule-like family member g	2						apical plasma membrane|basolateral plasma membrane|integral to membrane|multivesicular body membrane	receptor activity			central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(5)|skin(4)	19		Breast(137;0.0199)		BRCA - Breast invasive adenocarcinoma(366;0.115)		GCCCAGAATGCGGCTTCTGGT	0.602000													5	502					0	0	1	0	0
NBPF9	400818	broad.mit.edu	37	1	144828704	144828704	+	Missense_Mutation	SNP	T	T	G			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr1:144828704T>G	ENST00000338347.4	+	14	1750	c.1750T>G	c.(1750-1752)Tac>Gac	p.Y584D	NBPF9_ENST00000440491.2_3'UTR|NBPF9_ENST00000281815.8_Missense_Mutation_p.Y182D|NBPF9_ENST00000468645.1_3'UTR					neuroblastoma breakpoint family, member 9									p.L657L(3)|p.Y584D(1)		NS(2)|prostate(1)	3						CTTCGCCCTTTACGTGGACAA	0.438000													6	675					0	0	1	0	0
ANKRD30BP2	0	broad.mit.edu	37	21	14414844	14414844	+	RNA	SNP	T	T	C	rs148060711	by1000genomes	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr21:14414844T>C	ENST00000507941.1	+	0	95																											ACTGGGCCTGTGCCAATGGCC	0.433000													10	296					0	0	1	0	0
FAM86DP	0	broad.mit.edu	37	3	75475709	75475709	+	RNA	SNP	T	T	C			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr3:75475709T>C	ENST00000459803.1	-	0	820					NR_024241.1													p.I261V(1)									CTCCGCAGGATCCCGACCAGC	0.562000													5	195					0	0	1	0	0
ZC3H13	23091	broad.mit.edu	37	13	46549566	46549566	+	Nonsense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr13:46549566G>A	ENST00000242848.4	-	12	2668	c.2320C>T	c.(2320-2322)Cga>Tga	p.R774*	ZC3H13_ENST00000282007.3_Nonsense_Mutation_p.R774*			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	774	Arg/Glu-rich.						nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		gctctttctcgttcccgttct	0.512000													5	379					0	0	1	0	0
PCYT1A	5130	broad.mit.edu	37	3	195965646	195965646	+	Silent	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr3:195965646G>A	ENST00000292823.2	-	10	1189	c.1017C>T	c.(1015-1017)tcC>tcT	p.S339S	PCYT1A_ENST00000431016.1_Silent_p.S339S|PCYT1A_ENST00000419333.1_Silent_p.S339S	NM_005017.2	NP_005008.2	P49585	PCY1A_HUMAN	phosphate cytidylyltransferase 1, choline, alpha	339	3 X repeats.					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity			cervix(1)|endometrium(3)|large_intestine(8)|lung(5)|ovary(1)	18	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	AAGTCTTGCCGGAGAAGGGCC	0.607000													4	209					0	0	1	0	0
ZFR	51663	broad.mit.edu	37	5	32407029	32407029	+	Silent	SNP	A	A	T	rs139769264		TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr5:32407029A>T	ENST00000265069.8	-	6	984	c.882T>A	c.(880-882)gcT>gcA	p.A294A		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	294	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding	p.A294A(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		cagcagcagcagctgctgctg	0.483000													5	236					0	0	1	0	0
ANKRD30BP2	0	broad.mit.edu	37	21	14414902	14414902	+	RNA	SNP	G	G	A	rs2821609	by1000genomes	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr21:14414902G>A	ENST00000507941.1	+	0	95																											CCAGCTTGACGTCCTTGATGG	0.443000													17	229					0	0	1	0	0
DENND6B	414918	broad.mit.edu	37	22	50752274	50752274	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr22:50752274C>T	ENST00000413817.2	-	14	1243	c.1172G>A	c.(1171-1173)cGc>cAc	p.R391H		NM_001001794.3	NP_001001794.3			DENN/MADD domain containing 6B																		CGCCTTGTCGCGGTGGAGGTG	0.677000													4	208					0	0	1	0	0
KRTAP5-5	439915	broad.mit.edu	37	11	1651483	1651483	+	Missense_Mutation	SNP	G	G	C			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr11:1651483G>C	ENST00000399676.2	+	1	451	c.413G>C	c.(412-414)gGc>gCc	p.G138A		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	138	8 X 4 AA repeats of C-C-X-P.					keratin filament		p.G138A(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TCCAAGGGGGGCTGTGGCTCC	0.692000													5	127					0	0	1	0	0
BDKRB1	0	broad.mit.edu	37	14	96730887	96730887	+	Missense_Mutation	SNP	A	A	G			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr14:96730887A>G	ENST00000216629.6	+	3	1474	c.868A>G	c.(868-870)Att>Gtt	p.I290V	RP11-404P21.3_ENST00000553638.1_RNA|BDKRB1_ENST00000553356.1_Intron	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	290					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		GGAGGACTTCATTGACCTGGG	0.522000													165	410					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56481660	56481660	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:56481660C>T	ENST00000267101.3	+	6	1135	c.695C>T	c.(694-696)gCc>gTc	p.A232V	ERBB3_ENST00000450146.2_Intron|ERBB3_ENST00000415288.2_Missense_Mutation_p.A173V	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	232					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			GATGAGTGTGCCGGGGGCTGC	0.547000													6	906					0	0	1	0	0
ZFYVE20	64145	broad.mit.edu	37	3	15115677	15115677	+	Missense_Mutation	SNP	C	C	T	rs147577833	byFrequency	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr3:15115677C>T	ENST00000253699.3	-	14	2580	c.1967G>A	c.(1966-1968)cGc>cAc	p.R656H	ZFYVE20_ENST00000476527.2_Missense_Mutation_p.R656H	NM_022340.2	NP_071735.2	Q9H1K0	RBNS5_HUMAN	zinc finger, FYVE domain containing 20	656	Necessary for the interaction with EHD1.|Necessary for the interaction with RAB5A.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|skin(3)|stomach(1)|urinary_tract(2)	26						TTTCAGGATGCGGGCTGAAGG	0.562000													8	908					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138649158	138649158	+	Silent	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr9:138649158G>A	ENST00000298480.5	+	9	764	c.690G>A	c.(688-690)ccG>ccA	p.P230P	KCNT1_ENST00000371757.2_Silent_p.P230P|KCNT1_ENST00000486577.2_Silent_p.P191P|KCNT1_ENST00000491806.2_Silent_p.P197P|KCNT1_ENST00000487664.1_Silent_p.P182P|KCNT1_ENST00000263604.3_Silent_p.P211P|KCNT1_ENST00000490355.2_Silent_p.P211P|KCNT1_ENST00000488444.2_Silent_p.P211P			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	230						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		TCTGGCCGCCGCTGCGGAACC	0.642000													152	307					0	0	1	0	0
CDC25B	994	broad.mit.edu	37	20	3778313	3778313	+	Missense_Mutation	SNP	G	G	A	rs146567070		TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:3778313G>A	ENST00000245960.5	+	2	942	c.245G>A	c.(244-246)cGc>cAc	p.R82H	CDC25B_ENST00000379598.5_Missense_Mutation_p.R18H|CDC25B_ENST00000344256.6_Missense_Mutation_p.R18H|CDC25B_ENST00000439880.2_Missense_Mutation_p.R68H|CDC25B_ENST00000340833.4_Missense_Mutation_p.R82H|CDC25B_ENST00000467519.1_3'UTR	NM_004358.3|NM_021872.2|NM_021873.2	NP_004349.1|NP_068658.1|NP_068659.1	P30305	MPIP2_HUMAN	cell division cycle 25B	82					cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			NS(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(1)	18						TTCCGCAGCCGCAGCCGCCTG	0.617000													6	633					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53686084	53686084	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:53686084G>A	ENST00000257934.4	+	28	5910	c.5819G>A	c.(5818-5820)aGt>aAt	p.S1940N	ESPL1_ENST00000552462.1_Missense_Mutation_p.S1940N	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	1940					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						CCAGTGCTGAGTCAAGGGGTG	0.527000													31	396					0	0	1	0	0
HRH3	11255	broad.mit.edu	37	20	60791076	60791076	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:60791076G>A	ENST00000340177.5	-	3	1608	c.1324C>T	c.(1324-1326)Cac>Tac	p.H442Y	HRH3_ENST00000317393.6_Missense_Mutation_p.H442Y	NM_007232.2	NP_009163.2	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	442					G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity			breast(1)|endometrium(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	9	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	TTCCAGCAGTGCTCCAGGGAG	0.662000													10	32					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49724304	49724304	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:49724304G>A	ENST00000551245.1	+	13	1787	c.1676G>A	c.(1675-1677)tGc>tAc	p.C559Y	TROAP_ENST00000547923.1_Missense_Mutation_p.C267Y|TROAP_ENST00000257909.3_Missense_Mutation_p.C559Y			Q12815	TROAP_HUMAN	trophinin associated protein	559	4 X 33 AA approximate tandem repeats.|Cys-rich.				cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						CTAGAGTCCTGCTGTAGGAGT	0.597000													7	477					0	0	1	0	0
KCNK6	9424	broad.mit.edu	37	19	38817290	38817290	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr19:38817290C>T	ENST00000263372.3	+	2	487	c.380C>T	c.(379-381)gCg>gTg	p.A127V		NM_004823.1	NP_004814.1	Q9Y257	KCNK6_HUMAN	potassium channel, subfamily K, member 6	127						voltage-gated potassium channel complex	inward rectifier potassium channel activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(3)	17	all_cancers(60;5.83e-07)		Lung(45;0.00047)|LUSC - Lung squamous cell carcinoma(53;0.000613)		Ibutilide(DB00308)|Quinidine(DB00908)	ATCGCCTTTGCGCTCCTGGGC	0.572000													5	561					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2339217	2339217	+	Silent	SNP	G	G	C			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr4:2339217G>C	ENST00000290974.2	-	5	867	c.528C>G	c.(526-528)gtC>gtG	p.V176V	ZFYVE28_ENST00000509171.1_Silent_p.V129V|ZFYVE28_ENST00000503000.1_Silent_p.V176V|ZFYVE28_ENST00000515312.1_Silent_p.V106V|ZFYVE28_ENST00000515169.1_Silent_p.V106V|ZFYVE28_ENST00000511071.1_Silent_p.V176V	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	176					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						CCATGGCCGAGACGTAGCTGC	0.597000													44	185					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1065446	1065446	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr5:1065446C>T	ENST00000264930.5	-	18	2432	c.2389G>A	c.(2389-2391)Gca>Aca	p.A797T		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	797					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	TTCCAGGATGCGGGCCAGGCC	0.657000													7	518					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29556978	29556978	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr17:29556978G>A	ENST00000358273.4	+	22	3359	c.2976G>A	c.(2974-2976)atG>atA	p.M992I	NF1_ENST00000356175.3_Missense_Mutation_p.M992I	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	992					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AAACAATGATGTTAAATCTGG	0.338000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			141	294					0	0	1	0	0
TMCO3	55002	broad.mit.edu	37	13	114193716	114193716	+	Silent	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr13:114193716G>A	ENST00000434316.2	+	10	1943	c.1584G>A	c.(1582-1584)ctG>ctA	p.L528L	TMCO3_ENST00000375391.1_Intron	NM_017905.4	NP_060375.4	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	528						integral to membrane	solute:hydrogen antiporter activity			NS(1)|endometrium(4)|large_intestine(9)|liver(1)|lung(8)|prostate(1)|stomach(1)	25	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			GCTGTTTCCTGGCTGGAGCGC	0.627000													6	325					0	0	1	0	0
NDUFS6	4726	broad.mit.edu	37	5	1814533	1814533	+	Silent	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr5:1814533C>T	ENST00000274137.5	+	3	285	c.267C>T	c.(265-267)ggC>ggT	p.G89G	NDUFS6_ENST00000469176.1_Silent_p.G89G	NM_004553.4	NP_004544.1	O75380	NDUS6_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)	89					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|prostate(1)	7					NADH(DB00157)	CGTGCGATGGCGGCGGGGGAG	0.542000													5	504					0	0	1	0	0
PHC1	1911	broad.mit.edu	37	12	9085340	9085340	+	Silent	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:9085340G>A	ENST00000433083.2	+	7	1297	c.1152G>A	c.(1150-1152)caG>caA	p.Q384Q	PHC1_ENST00000544916.1_Silent_p.Q429Q|PHC1_ENST00000536844.1_Silent_p.Q208Q|PHC1_ENST00000543824.1_Silent_p.Q429Q|PHC1_ENST00000433847.2_3'UTR			P78364	PHC1_HUMAN	polyhomeotic homolog 1 (Drosophila)	429					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|large_intestine(8)|liver(2)|lung(3)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	27						agcagcagcagcaacaacagc	0.622000													5	191					0	0	1	0	0
CCDC138	165055	broad.mit.edu	37	2	109408155	109408155	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr2:109408155C>A	ENST00000295124.4	+	4	351	c.291C>A	c.(289-291)ttC>ttA	p.F97L	CCDC138_ENST00000470608.1_Intron|CCDC138_ENST00000412964.2_Missense_Mutation_p.F97L	NM_144978.1	NP_659415.1	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	97										endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	14						TGGATTCTTTCCATGATTTGA	0.284000													111	162					3.60366e-59	3.9363e-59	1	1	0
HLA-DQB2	3120	broad.mit.edu	37	6	32725596	32725596	+	Silent	SNP	C	C	G	rs115565146	by1000genomes	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr6:32725596C>G	ENST00000435145.2	-	4	772	c.711G>C	c.(709-711)ctG>ctC	p.L237L	HLA-DQB2_ENST00000411527.1_Intron|HLA-DQB2_ENST00000437316.2_Silent_p.L237L			Q5SR06	Q5SR06_HUMAN	major histocompatibility complex, class II, DQ beta 2	216					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex				endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						CGAGGAAGATCAGCCCCAGCA	0.562000													9	70					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104747966	104747966	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr7:104747966C>T	ENST00000334877.4	+	22	3596	c.3062C>T	c.(3061-3063)tCa>tTa	p.S1021L	KMT2E_ENST00000257745.4_Missense_Mutation_p.S1021L|KMT2E_ENST00000334914.7_Missense_Mutation_p.S76L|KMT2E_ENST00000311117.3_Missense_Mutation_p.S1021L					lysine (K)-specific methyltransferase 2E																		GAACCTGTGTCAGACCTTCAG	0.507000													104	238					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													6	135					0	0	1	0	0
ARMC9	80210	broad.mit.edu	37	2	232104736	232104736	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr2:232104736C>A	ENST00000349938.4	+	9	1055	c.861C>A	c.(859-861)gaC>gaA	p.D287E	ARMC9_ENST00000483477.1_3'UTR	NM_001271466.1|NM_025139.3	NP_001258395.1|NP_079415.3	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	287							binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		ATAGTGTGGACTTCACGAGGC	0.532000													4	59					1	1	1	1	0
UBN2	254048	broad.mit.edu	37	7	138944016	138944016	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr7:138944016C>T	ENST00000288561.8	+	5	805	c.556C>T	c.(556-558)Ccc>Tcc	p.P186S	UBN2_ENST00000473989.2_Missense_Mutation_p.P269S	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2	269										NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						TTTGCAGGTCCCCAAAATAAA	0.383000													59	162					0	0	1	0	0
RP11-85G18.6	0	broad.mit.edu	37	10	27536507	27536507	+	RNA	SNP	G	G	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr10:27536507G>T	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							CTCCCTTGGGGCTGGACTCCC	0.537000													55	69					3.37225e-12	3.57357e-12	1	1	0
FRG1B	0	broad.mit.edu	37	20	29625905	29625905	+	Missense_Mutation	SNP	T	T	C	rs137871677	by1000genomes	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:29625905T>C	ENST00000278882.3	+	5	529	c.149T>C	c.(148-150)cTt>cCt	p.L50P	FRG1B_ENST00000358464.4_Missense_Mutation_p.L50P|FRG1B_ENST00000439954.2_Missense_Mutation_p.L55P														p.L50P(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGAAAATATCTTGGTATAAAT	0.333000													6	521					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45133322	45133322	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:45133322G>A	ENST00000593880.1	-	2	389	c.95C>T	c.(94-96)aCt>aTt	p.T32I	ZNF334_ENST00000347606.4_Silent_p.L27L|ZNF334_ENST00000457685.2_5'UTR			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	0	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				GCAGGGTCCAGTTGCTGCCAT	0.468000													120	455					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628245	29628245	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:29628245G>A	ENST00000278882.3	+	6	627	c.247G>A	c.(247-249)Gcc>Acc	p.A83T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A83T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A88T														p.A83T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTTTGTTGGCCTCAAATAG	0.353000													5	526					0	0	1	0	0
NKIRAS2	28511	broad.mit.edu	37	17	40174482	40174482	+	Nonsense_Mutation	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr17:40174482C>T	ENST00000307641.5	+	3	781	c.160C>T	c.(160-162)Cga>Tga	p.R54*	NKIRAS2_ENST00000393880.1_Nonsense_Mutation_p.R54*|NKIRAS2_ENST00000316082.4_Nonsense_Mutation_p.R54*|NKIRAS2_ENST00000462043.2_Intron|NKIRAS2_ENST00000449471.4_Nonsense_Mutation_p.R54*|NKIRAS2_ENST00000393885.4_Nonsense_Mutation_p.R54*|NKIRAS2_ENST00000479407.1_Nonsense_Mutation_p.R54*|NKIRAS2_ENST00000393881.3_Nonsense_Mutation_p.R54*|NKIRAS2_ENST00000393884.2_Nonsense_Mutation_p.R52*	NM_001001349.2	NP_001001349.1	Q9NYR9	KBRS2_HUMAN	NFKB inhibitor interacting Ras-like 2	54	Small GTPase-like.				I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	9		all_cancers(22;1.1e-05)|Breast(137;0.000143)|all_epithelial(22;0.000319)				CCGGGGGGTGCGAGAGCAGGT	0.562000													4	235					0	0	1	0	0
SNAP47	116841	broad.mit.edu	37	1	227935772	227935772	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr1:227935772C>T	ENST00000366759.4	+	2	884	c.470C>T	c.(469-471)gCa>gTa	p.A157V	SNAP47_ENST00000366760.1_Intron|SNAP47_ENST00000315781.5_Missense_Mutation_p.A157V	NM_053052.3	NP_444280.2	Q5SQN1	SNP47_HUMAN	synaptosomal-associated protein, 47kDa	157	t-SNARE coiled-coil homology 1.					endomembrane system|membrane|perinuclear region of cytoplasm				endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17						GTGGCAGACGCATCTGTCCCA	0.632000													95	79					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811099	140811099	+	Splice_Site	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr4:140811099C>T	ENST00000398940.1	-	1	107	c.108_splice	c.e1+1	p.Q36_splice	MAML3_ENST00000509479.2_Silent_p.Q497Q|MAML3_ENST00000327122.5_Silent_p.Q341Q			Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	497					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity	p.Q497Q(2)		breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.542000													4	176					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76778782	76778782	+	Missense_Mutation	SNP	A	A	C			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chrX:76778782A>C	ENST00000373344.5	-	31	7011	c.6797T>G	c.(6796-6798)tTg>tGg	p.L2266W	ATRX_ENST00000395603.3_Missense_Mutation_p.L2228W|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	2266					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TTCTTCAGTCAACTCTTCTTC	0.373000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						358	13					0	0	1	0	0
NAA16	79612	broad.mit.edu	37	13	41929345	41929345	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr13:41929345C>A	ENST00000379406.3	+	10	1404	c.1080C>A	c.(1078-1080)agC>agA	p.S360R	NAA16_ENST00000379367.3_Missense_Mutation_p.S360R|NAA16_ENST00000403412.3_Missense_Mutation_p.S360R	NM_024561.4	NP_078837.3	Q6N069	NAA16_HUMAN	N(alpha)-acetyltransferase 16, NatA auxiliary subunit	360					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|urinary_tract(2)	31						ACTTTTTTAGCCCATATGGTA	0.264000													118	516					4.55767e-64	5.05616e-64	1	1	0
ACAD10	80724	broad.mit.edu	37	12	112165781	112165781	+	Silent	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:112165781C>T	ENST00000455480.2	+	10	1347	c.1170C>T	c.(1168-1170)ccC>ccT	p.P390P	ACAD10_ENST00000549590.1_Silent_p.P359P|ACAD10_ENST00000413681.3_3'UTR|ACAD10_ENST00000392636.2_Intron|ACAD10_ENST00000313698.4_Silent_p.P359P	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	359							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						TTGGCACCCCCTTCTATGTGA	0.517000													391	558					0	0	1	0	0
GCG	2641	broad.mit.edu	37	2	163003928	163003928	+	Silent	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr2:163003928G>A	ENST00000418842.2	-	3	443	c.189C>T	c.(187-189)agC>agT	p.S63S	GCG_ENST00000375497.3_Silent_p.S63S	NM_002054.4	NP_002045.1	P01275	GLUC_HUMAN	glucagon	63					cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity			breast(1)|central_nervous_system(1)|large_intestine(3)|lung(9)	14					Exenatide(DB01276)|Phentolamine(DB00692)	CCAGATACTTGCTGTAGTCAC	0.488000													97	568					0	0	1	0	0
CDR1	1038	broad.mit.edu	37	X	139866027	139866027	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chrX:139866027G>A	ENST00000370532.2	-	1	696	c.505C>T	c.(505-507)Cgt>Tgt	p.R169C		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	169	6 X 6 AA approximate repeats.							p.R169C(1)		breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				GAAAATCCACGTCTTCCCAAC	0.423000													10	299					0	0	1	0	0
SMARCE1	6605	broad.mit.edu	37	17	38788474	38788474	+	Silent	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr17:38788474C>T	ENST00000348513.6	-	8	1467	c.687G>A	c.(685-687)cgG>cgA	p.R229R	SMARCE1_ENST00000400122.3_Silent_p.R159R|SMARCE1_ENST00000377808.4_Silent_p.R194R|SMARCE1_ENST00000578044.1_Silent_p.R159R|SMARCE1_ENST00000580419.1_Silent_p.R194R|SMARCE1_ENST00000544009.1_Silent_p.R159R|SMARCE1_ENST00000431889.2_Silent_p.R211R|KRT222_ENST00000476049.1_3'UTR	NM_003079.4	NP_003070.3	Q969G3	SMCE1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	229					chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity			large_intestine(1)	1		Breast(137;0.000812)				ACTGGACCTGCCGTTTGAGGA	0.448000													6	493					0	0	1	0	0
DAZAP1	26528	broad.mit.edu	37	19	1428858	1428858	+	Silent	SNP	T	T	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr19:1428858T>A	ENST00000336761.6	+	8	769	c.564T>A	c.(562-564)gcT>gcA	p.A188A	DAZAP1_ENST00000233078.4_Silent_p.A188A|DAZAP1_ENST00000586579.1_3'UTR	NM_170711.1	NP_733829.1	Q96EP5	DAZP1_HUMAN	DAZ associated protein 1	188	RRM 2.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(2)|endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTAAACGAGCTGAGCCTCGGG	0.627000													30	289					0	0	1	0	0
KCNK7	10089	broad.mit.edu	37	11	65360906	65360906	+	Missense_Mutation	SNP	C	C	G			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr11:65360906C>G	ENST00000394216.2	-	2	982	c.759G>C	c.(757-759)aaG>aaC	p.K253N	KCNK7_ENST00000340313.4_Intron|KCNK7_ENST00000342202.4_Intron|KCNK7_ENST00000394217.2_Intron	NM_005714.1|NM_033455.1	NP_005705.1|NP_258416.1	Q9Y2U2	KCNK7_HUMAN	potassium channel, subfamily K, member 7	0						integral to membrane	potassium channel activity|voltage-gated ion channel activity			endometrium(1)|liver(1)|lung(1)	3						CCAGGCTCCTCTTCCCCCTTC	0.652000													81	97					0	0	1	0	0
SND1	27044	broad.mit.edu	37	7	127732106	127732106	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr7:127732106G>A	ENST00000354725.3	+	24	2923	c.2729G>A	c.(2728-2730)cGc>cAc	p.R910H		NM_014390.2	NP_055205.2	Q7KZF4	SND1_HUMAN	staphylococcal nuclease and tudor domain containing 1	910					gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	41						GGCTACAGCCGCTAAGGAGGG	0.557000													6	556					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216288219	216288219	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr2:216288219T>C	ENST00000354785.4	-	9	1616	c.1247A>G	c.(1246-1248)aAt>aGt	p.N416S	FN1_ENST00000443816.1_Missense_Mutation_p.N416S|FN1_ENST00000432072.2_Missense_Mutation_p.N416S|FN1_ENST00000336916.4_Missense_Mutation_p.N416S|FN1_ENST00000426059.1_Missense_Mutation_p.N416S|FN1_ENST00000346544.3_Missense_Mutation_p.N416S|FN1_ENST00000421182.1_Missense_Mutation_p.N416S|FN1_ENST00000359671.1_Missense_Mutation_p.N416S|FN1_ENST00000357867.4_Missense_Mutation_p.N416S|FN1_ENST00000357009.2_Missense_Mutation_p.N416S|FN1_ENST00000323926.6_Missense_Mutation_p.N416S|FN1_ENST00000345488.5_Missense_Mutation_p.N416S|FN1_ENST00000356005.4_Missense_Mutation_p.N416S|FN1_ENST00000446046.1_Missense_Mutation_p.N416S			P02751	FINC_HUMAN	fibronectin 1	416	Collagen-binding.|Fibronectin type-II 2.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAAGGCACCATTGGAATTTCC	0.448000													36	46					0	0	1	0	0
PAX9	5083	broad.mit.edu	37	14	37132535	37132535	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr14:37132535C>A	ENST00000361487.6	+	2	663	c.438C>A	c.(436-438)caC>caA	p.H146Q	PAX9_ENST00000402703.2_Missense_Mutation_p.H146Q|PAX9_ENST00000554201.1_5'UTR			P55771	PAX9_HUMAN	paired box 9	146					multicellular organismal development|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(3)	12	Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.218)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.00998)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0181)		ACAAGCAGCACCAGCCGACGC	0.632000													79	169					4.75426e-39	5.11443e-39	1	1	0
GTF3C3	9330	broad.mit.edu	37	2	197657782	197657782	+	Silent	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr2:197657782C>T	ENST00000263956.3	-	3	398	c.309G>A	c.(307-309)gaG>gaA	p.E103E	GTF3C3_ENST00000409364.3_Silent_p.E103E	NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	103	Glu-rich.					transcription factor TFIIIC complex	DNA binding|protein binding	p.E103E(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						cctcctcctcctcttcttcct	0.468000													4	248					0	0	1	0	0
KRTAP9-9	81870	broad.mit.edu	37	17	39411940	39411940	+	Silent	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr17:39411940C>T	ENST00000394008.1	+	1	305	c.303C>T	c.(301-303)ggC>ggT	p.G101G		NM_030975.2	NP_112237.2	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	101						keratin filament				endometrium(3)|skin(2)|upper_aerodigestive_tract(1)	6		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CCAGCTGTGGCCAGAGCAGCT	0.617000													6	489					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28650816	28650816	+	Splice_Site	SNP	C	C	T	rs145831682	byFrequency	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr18:28650816C>T	ENST00000280904.6	-	14	2569	c.2125_splice	c.e14-1	p.C709_splice	DSC2_ENST00000251081.6_Splice_Site_p.C709_splice	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	709					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			AAACAGGATGCCTGGAGGAAG	0.343000													5	291					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229790000	229790000	+	Silent	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr1:229790000C>T	ENST00000258243.2	+	9	4378	c.4242C>T	c.(4240-4242)agC>agT	p.S1414S		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	1414						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						CTGTAGGAAGCATAGATGACC	0.423000													5	278					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20976647	20976647	+	Silent	SNP	T	T	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr16:20976647T>A	ENST00000261383.3	-	53	8558	c.8559A>T	c.(8557-8559)ccA>ccT	p.P2853P	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2853	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCATGGTCAGTGGGGGGATGT	0.458000													13	607					0	0	1	0	0
WDR5	11091	broad.mit.edu	37	9	137017152	137017152	+	Splice_Site	SNP	G	G	A	rs112881246		TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr9:137017152G>A	ENST00000358625.3	+	9	802		c.e9+1		WDR5_ENST00000425041.1_Splice_Site	NM_017588.2	NP_060058.1	P61964	WDR5_HUMAN	WD repeat domain 5						histone H3 acetylation|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|MLL1 complex|Set1C/COMPASS complex	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	9		Myeloproliferative disorder(178;0.0255)|Medulloblastoma(224;0.123)		Epithelial(140;6.61e-13)|all cancers(34;5.66e-12)|OV - Ovarian serous cystadenocarcinoma(145;3.93e-08)|GBM - Glioblastoma multiforme(294;0.00326)|READ - Rectum adenocarcinoma(205;0.154)		ACGCTCATCGGTGAGTGTGGC	0.592000													209	498					0	0	1	0	0
U47924.28	0	broad.mit.edu	37	12	7080041	7080041	+	RNA	SNP	T	T	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:7080041T>A	ENST00000261406.6	+	0	98																											GAAGCCGCGCTGTTCTTATTT	0.547000													14	42					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82882859	82882859	+	Splice_Site	SNP	G	G	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr11:82882859G>T	ENST00000298281.4	+	9	4112		c.e9-1			NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit						mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						TTTTCTTAAAGGTTCTGAGTG	0.338000													22	148					1.22574e-08	1.28929e-08	1	1	0
NCOA3	8202	broad.mit.edu	37	20	46279860	46279860	+	Silent	SNP	G	G	A	rs151060280	byFrequency	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:46279860G>A	ENST00000372004.3	+	20	3990	c.3774G>A	c.(3772-3774)caG>caA	p.Q1258Q	NCOA3_ENST00000371998.3_Silent_p.Q1262Q|NCOA3_ENST00000371997.3_Silent_p.Q1253Q|NCOA3_ENST00000341724.6_Silent_p.Q1188Q	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1262	Acetyltransferase.|Poly-Gln.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding	p.Q1262Q(1)		breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						agcagcagcagcagcaacagc	0.567000													7	254					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90161926	90161926	+	RNA	SNP	T	T	C	rs8061283	by1000genomes	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr16:90161926T>C	ENST00000567960.1	+	0	662				TUBB8P7_ENST00000564451.1_RNA														p.I221T(3)									CCCACACCCATCTATGGTGAC	0.527000													7	96					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49724313	49724313	+	Missense_Mutation	SNP	G	G	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:49724313G>T	ENST00000551245.1	+	13	1796	c.1685G>T	c.(1684-1686)aGt>aTt	p.S562I	TROAP_ENST00000547923.1_Missense_Mutation_p.S270I|TROAP_ENST00000257909.3_Missense_Mutation_p.S562I			Q12815	TROAP_HUMAN	trophinin associated protein	562	4 X 33 AA approximate tandem repeats.|Cys-rich.				cell adhesion	cytoplasm		p.S562I(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						TGCTGTAGGAGTGAGCCTGAG	0.592000													7	482					2.0095e-06	2.08284e-06	1	1	0
AHNAK	79026	broad.mit.edu	37	11	62295897	62295897	+	Silent	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr11:62295897G>A	ENST00000378024.4	-	5	6266	c.5992C>T	c.(5992-5994)Ctg>Ttg	p.L1998L	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1998					nervous system development	nucleus	protein binding	p.L1998L(1)		NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GGGCCTTTCAGGTGTAAGTCC	0.483000													7	1202					0	0	1	0	0
LINC00969	0	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													6	80					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43316118	43316118	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr10:43316118T>C	ENST00000374518.4	+	17	2995	c.2932T>C	c.(2932-2934)Tgc>Cgc	p.C978R		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	978					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity	p.C978R(1)		NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GCACATGCATTGCGGAGCAGC	0.423000													4	238					0	0	1	0	0
ZNF688	146542	broad.mit.edu	37	16	30581293	30581293	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr16:30581293G>A	ENST00000223459.6	-	3	1879	c.775C>T	c.(775-777)Cgg>Tgg	p.R259W	ZNF688_ENST00000395219.1_Missense_Mutation_p.R245W	NM_145271.3	NP_660314.1	P0C7X2	ZN688_HUMAN	zinc finger protein 688	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)	8						GGCGGGTCCCGGTCACCTCGG	0.706000													4	158					0	0	1	0	0
SRFBP1	153443	broad.mit.edu	37	5	121356407	121356407	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr5:121356407C>A	ENST00000339397.4	+	6	1049	c.977C>A	c.(976-978)aCa>aAa	p.T326K	SRFBP1_ENST00000504881.1_3'UTR	NM_152546.2	NP_689759.2	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	326					regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|skin(1)	15		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)		CATGGGGATACAAGAAATGAC	0.348000													121	116					3.41453e-61	3.75863e-61	1	1	0
AFAP1L2	84632	broad.mit.edu	37	10	116062116	116062116	+	Missense_Mutation	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr10:116062116G>A	ENST00000369271.3	-	12	1712	c.1412C>T	c.(1411-1413)gCg>gTg	p.A471V	AFAP1L2_ENST00000545353.1_Missense_Mutation_p.A524V|AFAP1L2_ENST00000304129.4_Missense_Mutation_p.A471V	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	471					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		GTTTTTGGCCGCACTCACAAT	0.542000													5	557					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107049640	107049640	+	Missense_Mutation	SNP	C	C	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr2:107049640C>A	ENST00000409886.3	-	16	2394	c.2307G>T	c.(2305-2307)ttG>ttT	p.L769F	RGPD3_ENST00000304514.7_Missense_Mutation_p.L769F	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	769					intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						CCGCATTTCGCAAAGAACCAT	0.393000													282	853					4.36536e-96	4.88095e-96	1	1	0
GTF3C4	9329	broad.mit.edu	37	9	135554771	135554771	+	Nonsense_Mutation	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr9:135554771C>T	ENST00000372146.4	+	2	2329	c.1765C>T	c.(1765-1767)Cag>Tag	p.Q589*		NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	589					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		TCAGTCAATGCAGAAAACCCC	0.418000													197	600					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													8	259					0	0	1	0	0
BPIFB2	80341	broad.mit.edu	37	20	31601685	31601685	+	Silent	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:31601685C>T	ENST00000170150.3	+	5	573	c.378C>T	c.(376-378)tcC>tcT	p.S126S		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	126						extracellular region	lipid binding										CCCAGAGCTCCATCAGGACCC	0.637000													88	276					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22661362	22661362	+	RNA	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr22:22661362C>T	ENST00000426066.1	+	0	360					NR_027293.1																						TGGGCAACAGCGAGGGAAATG	0.502000													6	242					0	0	1	0	0
PGGT1B	5229	broad.mit.edu	37	5	114548273	114548273	+	Missense_Mutation	SNP	C	C	G			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr5:114548273C>G	ENST00000419445.1	-	9	980	c.960G>C	c.(958-960)ttG>ttC	p.L320F	PGGT1B_ENST00000379615.3_Missense_Mutation_p.L243F	NM_005023.3	NP_005014.2	P53609	PGTB1_HUMAN	protein geranylgeranyltransferase type I, beta subunit	320					protein geranylgeranylation	CAAX-protein geranylgeranyltransferase complex	CAAX-protein geranylgeranyltransferase activity			breast(2)|endometrium(1)|large_intestine(2)|lung(1)	6		all_cancers(142;0.000523)|all_epithelial(76;6.45e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		Epithelial(69;2.95e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.98e-08)|all cancers(49;3.1e-06)	Pravastatin(DB00175)	AGTATGCATGCAAAGCATCTG	0.403000													76	286					0	0	1	0	0
AMH	268	broad.mit.edu	37	19	2250861	2250861	+	Missense_Mutation	SNP	T	T	G			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr19:2250861T>G	ENST00000221496.3	+	4	1344	c.678T>G	c.(676-678)agT>agG	p.S226R		NM_000479.3	NP_000470.2	P03971	MIS_HUMAN	anti-Mullerian hormone	226					cell differentiation|cell-cell signaling|gonadal mesoderm development|Mullerian duct regression|positive regulation of gene expression|sex determination	extracellular space	growth factor activity|hormone activity			lung(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCGGCTGAGTACCGCCCGGC	0.756000									Persistant Mullerian Duct Syndrome (type I and II)				4	43					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45284309	45284309	+	Splice_Site	SNP	G	G	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr19:45284309G>A	ENST00000270279.3	+	2	563		c.e2+1		CBLC_ENST00000341505.4_Splice_Site	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase						cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				GCGGAGCCCGGTGAGTAAGCC	0.652000			M		AML								8	213					0	0	1	0	0
ST6GALNAC4	27090	broad.mit.edu	37	9	130674853	130674853	+	Missense_Mutation	SNP	C	C	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr9:130674853C>T	ENST00000335791.5	-	4	580	c.305G>A	c.(304-306)cGc>cAc	p.R102H	ST6GALNAC4_ENST00000495983.1_5'UTR|ST6GALNAC4_ENST00000343609.2_Missense_Mutation_p.R18H	NM_175039.3	NP_778204.1	Q9H4F1	SIA7D_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4	102					glycolipid metabolic process|protein glycosylation	integral to Golgi membrane|nucleus|soluble fraction	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7						CTGGTTCATGCGGAACACGCA	0.677000													4	220					0	0	1	0	0
TBC1D3	729873	broad.mit.edu	37	17	36352489	36352489	+	Translation_Start_Site	SNP	A	A	C	rs4796259	by1000genomes	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr17:36352489A>C	ENST00000537432.1	-	0	359				RP11-1407O15.2_ENST00000312412.4_Missense_Mutation_p.F433C|RP11-1407O15.2_ENST00000544906.1_Missense_Mutation_p.F278C			Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3							intracellular	Rab GTPase activator activity			breast(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5	Breast(7;2.97e-12)	Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TATAGCATCAAATATCTCATC	0.388000													15	122					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													27	387					0	0	1	0	0
ZNF721	170960	broad.mit.edu	37	4	436563	436563	+	Missense_Mutation	SNP	T	T	C			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr4:436563T>C	ENST00000338977.5	-	2	1705	c.1657A>G	c.(1657-1659)Acc>Gcc	p.T553A	ZNF721_ENST00000506646.1_Intron|ZNF721_ENST00000511833.2_Missense_Mutation_p.T565A|ZNF721_ENST00000507078.1_Intron|ABCA11P_ENST00000451020.2_RNA					zinc finger protein 721											endometrium(2)|kidney(2)|large_intestine(15)|lung(6)|ovary(1)|skin(1)|stomach(5)|urinary_tract(1)	33						TGTCTAAAGGTTTTGCCACAT	0.418000													6	905					0	0	1	0	0
NR3C2	0	broad.mit.edu	37	4	149075976	149075976	+	Silent	SNP	T	T	G			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr4:149075976T>G	ENST00000355292.3	-	5	2465	c.2103A>C	c.(2101-2103)ccA>ccC	p.P701P	NR3C2_ENST00000358102.3_Silent_p.P697P|NR3C2_ENST00000342437.4_Intron|NR3C2_ENST00000512865.1_Intron|NR3C2_ENST00000503313.1_5'UTR|NR3C2_ENST00000344721.4_Silent_p.P697P|RP11-76G10.1_ENST00000514843.1_RNA|NR3C2_ENST00000511528.1_Silent_p.P701P			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	697	Hinge.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	ggggtgggggtgggggtgggg	0.527000													9	97					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74575212	74575213	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr1:74575212_74575213insT	ENST00000354431.4	-	5	923_924	c.732_733insA	c.(730-735)aaagcafs	p.A245fs	LRRIQ3_ENST00000370909.2_Frame_Shift_Ins_p.A137fs|LRRIQ3_ENST00000395089.1_Frame_Shift_Ins_p.A245fs|LRRIQ3_ENST00000468759.1_5'UTR	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	245				QQEKII -> TAGKNY (in Ref. 1; BAD18621).						NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TTTTCCTGCTGTTTTTTTTTGT	0.327													17	298	---	---	---	---					
BCL10	8915	broad.mit.edu	37	1	85736511	85736511	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr1:85736511delT	ENST00000370580.1	-	2	873	c.136delA	c.(136-138)tafs	p.I46fs		NM_003921.4	NP_003912.1	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	46	CARD.				apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding	p.I46fs*4(1)		haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	19				all cancers(265;0.0114)|Epithelial(280;0.0311)		CTACTGAGTATTTTTTTTGCA	0.343			T	IGH@	MALT								7	274	---	---	---	---					
ABCA4	24	broad.mit.edu	37	1	94466574	94466574	+	Frame_Shift_Del	DEL	C	C	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr1:94466574delC	ENST00000370225.3	-	46	6456	c.6370delG	c.(6370-6372)tcfs	p.V2124fs	ABCA4_ENST00000535881.1_Frame_Shift_Del_p.V243fs|ABCA4_ENST00000536513.1_Frame_Shift_Del_p.V394fs	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	2124	ABC transporter 2.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GATGTGAGGACCACAGCCCTC	0.617													120	222	---	---	---	---					
WDR3	10885	broad.mit.edu	37	1	118485115	118485115	+	Frame_Shift_Del	DEL	C	C	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr1:118485115delC	ENST00000349139.4	+	10	1092	c.1045delC	c.(1045-1047)tgfs	p.L349fs		NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3	349						nuclear membrane|nucleolus		p.L349V(1)		breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		TGAAATGAGTCTGCAAGATGA	0.333													195	288	---	---	---	---					
RP11-782C8.2	0	broad.mit.edu	37	1	143210193	143210194	+	RNA	INS	-	-	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr1:143210193_143210194insT	ENST00000412204.2	-	0	876_877				RP11-782C8.1_ENST00000438000.1_lincRNA																							GGCAGCATTTGTTTTTTTAACA	0.317													8	241	---	---	---	---					
AFTPH	54812	broad.mit.edu	37	2	64778672	64778674	+	In_Frame_Del	DEL	GAT	GAT	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr2:64778672_64778674delGAT	ENST00000422803.1	+	2	378_380	c.64_66delGAT	c.(64-66)del	p.D26del	AFTPH_ENST00000409933.1_In_Frame_Del_p.D26del|AFTPH_ENST00000238855.7_In_Frame_Del_p.D26del|AFTPH_ENST00000238856.4_In_Frame_Del_p.D26del			Q6ULP2	AFTIN_HUMAN	aftiphilin	26					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	35						TGGAGCAGAGGATGATGATGATG	0.409													8	576	---	---	---	---					
AC067960.1	0	broad.mit.edu	37	2	121840249	121840249	+	RNA	DEL	G	G	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr2:121840249delG	ENST00000441053.1	-	0	206																											GGCTAGGGCTGGGGGGATGGT	0.602													4	7	---	---	---	---					
DYNC1LI1	51143	broad.mit.edu	37	3	32571050	32571050	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr3:32571050delT	ENST00000273130.4	-	11	1391	c.1288delA	c.(1288-1290)ttfs	p.I430fs	DYNC1LI1_ENST00000432458.2_Frame_Shift_Del_p.I314fs	NM_016141.3	NP_057225.2	Q9Y6G9	DC1L1_HUMAN	dynein, cytoplasmic 1, light intermediate chain 1	430					cell division|interspecies interaction between organisms|mitosis|positive regulation of mitotic cell cycle spindle assembly checkpoint|transport	centrosome|condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|plasma membrane|spindle pole	ATP binding|motor activity			kidney(2)|large_intestine(1)|lung(3)|ovary(1)	7						TTTGGATCAATTTTTTTTGAC	0.398													7	233	---	---	---	---					
HESX1	8820	broad.mit.edu	37	3	57232250	57232250	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr3:57232250delT	ENST00000295934.3	-	4	569	c.533delA	c.(532-534)atfs	p.N178fs	HESX1_ENST00000473921.1_Frame_Shift_Del_p.N144fs	NM_003865.2	NP_003856.1	Q9UBX0	HESX1_HUMAN	HESX homeobox 1	178						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(2)|lung(1)|ovary(1)|prostate(1)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(284;0.0109)|Kidney(284;0.0126)		TGTGTTGAAATTTTTTTTCGC	0.308													7	397	---	---	---	---					
SLC9A9	285195	broad.mit.edu	37	3	143551065	143551066	+	Splice_Site	INS	-	-	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr3:143551065_143551066insA	ENST00000316549.6	-	2	384		c.e2-2			NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9						regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						TTATAAGGCCTAAAAAAAAAAG	0.347													8	120	---	---	---	---					
MED12L	116931	broad.mit.edu	37	3	151148114	151148116	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr3:151148114_151148116delCAG	ENST00000474524.1	+	42	6369_6371	c.6331_6333delCAG	c.(6331-6333)del	p.Q2115del	MED12L_ENST00000273432.4_In_Frame_Del_p.Q1779del	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	2115	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex		p.Q2111E(1)		NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCAGCAGACCCAGCAGCAGCAGC	0.527													9	335	---	---	---	---					
TMEM41A	90407	broad.mit.edu	37	3	185212517	185212518	+	Frame_Shift_Ins	INS	-	-	A	rs150885877	byFrequency	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr3:185212517_185212518insA	ENST00000421852.1	-	4	562_563	c.467_468insT	c.(466-468)tttfs	p.F156fs	TMEM41A_ENST00000296254.3_Intron|TMEM41A_ENST00000475480.1_5'UTR	NM_080652.3	NP_542383.1	Q96HV5	TM41A_HUMAN	transmembrane protein 41A	156						integral to membrane				large_intestine(1)|lung(2)|skin(1)	4	all_cancers(143;7.78e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AAAACAATAAGAAAAAAAACAA	0.446													7	483	---	---	---	---					
RP11-453E17.1	0	broad.mit.edu	37	4	68632418	68632419	+	RNA	INS	-	-	AT	rs59536241	by1000genomes	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr4:68632418_68632419insAT	ENST00000500538.2	+	0	1905				RP11-453E17.1_ENST00000502758.1_RNA																							cacacacacacaTATATATAct	0.431													14	12	---	---	---	---					
ADAD1	132612	broad.mit.edu	37	4	123302211	123302211	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr4:123302211delA	ENST00000296513.2	+	4	422	c.237delA	c.(235-237)ccfs	p.P79fs	ADAD1_ENST00000388724.2_Frame_Shift_Del_p.P79fs|ADAD1_ENST00000492454.1_3'UTR|ADAD1_ENST00000388725.2_Frame_Shift_Del_p.P61fs	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	79					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						TCCTTCCTCCAAAAAAAATAC	0.358													9	513	---	---	---	---					
MMAA	166785	broad.mit.edu	37	4	146563617	146563619	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr4:146563617_146563619delCTT	ENST00000281317.5	+	3	1752_1754	c.542_544delCTT	c.(541-546)cct>c	p.PS181del	MMAA_ENST00000541599.1_5'UTR|RP11-557J10.4_ENST00000504555.1_RNA	NM_172250.2	NP_758454.1	Q8IVH4	MMAA_HUMAN	methylmalonic aciduria (cobalamin deficiency) cblA type	181						mitochondrion	GTP binding|nucleoside-triphosphatase activity	p.P181H(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)	17	all_hematologic(180;0.151)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCTGTGGACCCTTCTTCTTGTAC	0.429													280	1191	---	---	---	---					
FHDC1	85462	broad.mit.edu	37	4	153893619	153893619	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr4:153893619delA	ENST00000511601.1	+	11	1497	c.1309delA	c.(1309-1311)aafs	p.K438fs	FHDC1_ENST00000260008.3_Frame_Shift_Del_p.K438fs			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	438	FH2.				actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					CTGTGAAGACAAAAAAACCAT	0.403													8	767	---	---	---	---					
FRG1	2483	broad.mit.edu	37	4	190873437	190873439	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr4:190873437_190873439delAAG	ENST00000226798.4	+	3	476_478	c.254_256delAAG	c.(253-258)aaa>a	p.KE85del	FRG1_ENST00000514482.1_3'UTR	NM_004477.2	NP_004468.1	Q14331	FRG1_HUMAN	FSHD region gene 1	85					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus				NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		GCTCCACACAAAGAAGGTTTGTG	0.414													7	864	---	---	---	---					
ZDHHC11	79844	broad.mit.edu	37	5	848671	848671	+	Frame_Shift_Del	DEL	G	G	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr5:848671delG	ENST00000283441.8	-	2	710	c.327delC	c.(325-327)ccfs	p.P109fs	ZDHHC11_ENST00000424784.2_Frame_Shift_Del_p.P109fs	NM_024786.2	NP_079062.1	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	109						integral to membrane	acyltransferase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(10)|pancreas(1)|prostate(5)|skin(2)|urinary_tract(1)	21			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			AGAGGGGCATGGGCTGAGAAT	0.592													7	57	---	---	---	---					
AC026703.1	0	broad.mit.edu	37	5	32789822	32789823	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr5:32789822_32789823delGT	ENST00000326958.1	+	1	878_879	c.315_316delGT	c.(313-318)gggtfs	p.GC105fs	NPR3_ENST00000265074.8_3'UTR																							CTGATTTTGGGTGTGTGTGTGT	0.421													15	560	---	---	---	---					
CARD6	84674	broad.mit.edu	37	5	40853093	40853094	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr5:40853093_40853094insT	ENST00000254691.5	+	3	1858_1859	c.1659_1660insT	c.(1657-1662)gtttttfs	p.VF553fs	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	553					apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						CTTCAGCTGTGTTTTTTTTCAC	0.416													9	789	---	---	---	---					
SLC22A4	6583	broad.mit.edu	37	5	131676327	131676327	+	Frame_Shift_Del	DEL	T	T	-	rs72552721		TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr5:131676327delT	ENST00000200652.3	+	9	1688	c.1514delT	c.(1513-1515)ctfs	p.L505fs	AC034220.3_ENST00000437091.1_RNA|AC034220.3_ENST00000417795.1_RNA	NM_003059.2	NP_003050.2	Q9H015	S22A4_HUMAN	solute carrier family 22 (organic cation/zwitterion transporter), member 4	505					body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity	p.E509fs*1(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|urinary_tract(1)	16		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	ATCCTCACCCTTTTTTTCCCT	0.418													7	1091	---	---	---	---					
VDAC1	7416	broad.mit.edu	37	5	133316639	133316639	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr5:133316639delT	ENST00000265333.3	-	6	576	c.332delA	c.(331-333)atfs	p.N111fs	VDAC1_ENST00000395047.2_Frame_Shift_Del_p.N111fs|VDAC1_ENST00000395044.3_Frame_Shift_Del_p.N111fs	NM_003374.2	NP_003365.1	P21796	VDAC1_HUMAN	voltage-dependent anion channel 1	111					apoptosis|interspecies interaction between organisms	mitochondrial nucleoid|mitochondrial outer membrane|plasma membrane|pore complex	porin activity|protein binding|voltage-gated anion channel activity			endometrium(1)|large_intestine(1)|lung(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)		Dihydroxyaluminium(DB01375)	GATTTTAGCATTTTTTTTCCT	0.403													7	408	---	---	---	---					
ZNF322	79692	broad.mit.edu	37	6	26637624	26637624	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr6:26637624delT	ENST00000415922.2	-	4	1803	c.1158delA	c.(1156-1158)aafs	p.K386fs	ZNF322_ENST00000471278.1_Frame_Shift_Del_p.K386fs	NM_024639.4	NP_078915.2	Q6U7Q0	Z322A_HUMAN	zinc finger protein 322	386					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding										GCTCAAGACCTTTTTCACTCA	0.413													7	1380	---	---	---	---					
TTK	7272	broad.mit.edu	37	6	80751896	80751897	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr6:80751896_80751897insA	ENST00000509894.1	+	22	3377_3378	c.2548_2549insA	c.(2548-2550)aaafs	p.K850fs	TTK_ENST00000369798.2_Frame_Shift_Ins_p.K851fs|TTK_ENST00000230510.3_Frame_Shift_Ins_p.K850fs			P33981	TTK_HUMAN	TTK protein kinase	851					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R838fs*4(3)|p.R838fs*>4(2)|p.R838fs*>5(1)		endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		CAAGACTTTTGAAAAAAAAAGG	0.302													7	347	---	---	---	---					
GRIK2	2898	broad.mit.edu	37	6	102503431	102503432	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr6:102503431_102503432insA	ENST00000369138.1	+	15	3028_3029	c.2538_2539insA	c.(2536-2541)tcaaaafs	p.SK846fs	GRIK2_ENST00000421544.1_Frame_Shift_Ins_p.SK846fs|GRIK2_ENST00000369134.4_Frame_Shift_Ins_p.SK797fs|GRIK2_ENST00000413795.1_Frame_Shift_Ins_p.SK846fs|GRIK2_ENST00000369137.3_Frame_Shift_Ins_p.SK770fs|GRIK2_ENST00000318991.6_Frame_Shift_Ins_p.SK846fs	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	846					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity	p.N849fs*12(1)|p.N849fs*14(1)		NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TATACAAATCCAAAAAAAACGC	0.351													9	371	---	---	---	---					
AC007255.7	0	broad.mit.edu	37	7	29720482	29720483	+	RNA	INS	-	-	G	rs70980562		TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr7:29720482_29720483insG	ENST00000426767.1	-	0	366					NR_024278.1																						CTCTCAGATCAGTGATGCCCTG	0.485													12	148	---	---	---	---					
CCT6P3	0	broad.mit.edu	37	7	64528813	64528814	+	RNA	INS	-	-	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr7:64528813_64528814insT	ENST00000426828.1	+	0	621					NR_033416.1																						CTTTCTGTAACTTTTTTTTTTT	0.317													7	32	---	---	---	---					
STEAP2	261729	broad.mit.edu	37	7	89856465	89856465	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr7:89856465delT	ENST00000287908.3	+	3	1066	c.673delT	c.(673-675)ttfs	p.F227fs	STEAP2_ENST00000394622.2_Frame_Shift_Del_p.F227fs|STEAP2_ENST00000394626.1_Frame_Shift_Del_p.F227fs|STEAP2_ENST00000394629.2_Frame_Shift_Del_p.F227fs|STEAP2_ENST00000394632.1_Frame_Shift_Del_p.F227fs|STEAP2_ENST00000402625.2_Frame_Shift_Del_p.F227fs|STEAP2_ENST00000394621.2_Frame_Shift_Del_p.F227fs	NM_001244944.1|NM_152999.3	NP_001231873.1|NP_694544.2	Q8NFT2	STEA2_HUMAN	STEAP family member 2, metalloreductase	227					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15	all_hematologic(106;0.112)					CTTGGCCACATTTTTTTTCCT	0.393													7	636	---	---	---	---					
CYP51A1	1595	broad.mit.edu	37	7	91752494	91752494	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr7:91752494delT	ENST00000003100.8	-	7	1191	c.1026delA	c.(1024-1026)aafs	p.K342fs	CYP51A1_ENST00000450723.1_Frame_Shift_Del_p.K237fs|LRRD1_ENST00000422722.1_5'UTR	NM_000786.3	NP_000777.1	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A, polypeptide 1	336					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)	10	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	CTAAATAACATTTTTTTTGAA	0.398													11	764	---	---	---	---					
SAMD9L	219285	broad.mit.edu	37	7	92760737	92760738	+	Frame_Shift_Ins	INS	-	-	T	rs10282508	byFrequency	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr7:92760737_92760738insT	ENST00000318238.4	-	5	5763_5764	c.4547_4548insA	c.(4546-4548)agafs	p.R1516fs	SAMD9L_ENST00000437805.1_Frame_Shift_Ins_p.R1516fs|SAMD9L_ENST00000411955.1_Frame_Shift_Ins_p.R1516fs	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1516			N -> T (in dbSNP:rs10282508).							central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CTTTGACTTCATTTTTTTTCCA	0.391													8	677	---	---	---	---					
TRBV7-4	0	broad.mit.edu	37	7	142176678	142176679	+	RNA	DEL	CA	CA	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr7:142176678_142176679delCA	ENST00000390369.2	-	0	49																											GTAGTCATCGCACACACACACA	0.460													14	260	---	---	---	---					
WRN	7486	broad.mit.edu	37	8	30945377	30945379	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr8:30945377_30945379delAAG	ENST00000298139.5	+	12	1766_1768	c.1517_1519delAAG	c.(1516-1521)aaa>a	p.KE506del		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	506					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CTTCCTACTAaagaagaagaaga	0.360			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				8	444	---	---	---	---					
PREX2	80243	broad.mit.edu	37	8	68992720	68992721	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr8:68992720_68992721insT	ENST00000288368.4	+	16	1962_1963	c.1685_1686insT	c.(1684-1686)cttfs	p.L562fs	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	562	DEP 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CTACTTTTCCGTTTTTTTTCGG	0.332													7	368	---	---	---	---					
TP53INP1	0	broad.mit.edu	37	8	95952409	95952411	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr8:95952409_95952411delTCT	ENST00000342697.4	-	3	557_559	c.150_152delAGA	c.(148-153)gag>ga	p.EE50del	TP53INP1_ENST00000378776.4_In_Frame_Del_p.EE50del|TP53INP1_ENST00000448464.2_In_Frame_Del_p.EE50del|NDUFAF6_ENST00000396113.1_Intron	NM_033285.3	NP_150601.1	Q96A56	T53I1_HUMAN	tumor protein p53 inducible nuclear protein 1	50	Glu-rich.				apoptosis	PML body		p.E50E(1)		kidney(2)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	9	Breast(36;8.75e-07)					GATGTCCTCCTCTTCTTCTTCTT	0.458													10	374	---	---	---	---					
DPYS	1807	broad.mit.edu	37	8	105440214	105440214	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr8:105440214delT	ENST00000351513.2	-	6	1218	c.1086delA	c.(1084-1086)aafs	p.K362fs		NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	362					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CCACCACGCCTTTTTCCCATA	0.478													8	1351	---	---	---	---					
AGO2	27161	broad.mit.edu	37	8	141554345	141554345	+	Frame_Shift_Del	DEL	G	G	-	rs148575703	byFrequency	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr8:141554345delG	ENST00000220592.5	-	14	1918	c.1806delC	c.(1804-1806)ccfs	p.P602fs	AGO2_ENST00000519980.1_Frame_Shift_Del_p.P602fs	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2																		CATCCCCGGCGGGGGGGTGAG	0.647													7	1615	---	---	---	---					
PLIN2	123	broad.mit.edu	37	9	19119813	19119813	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr9:19119813delT	ENST00000276914.2	-	6	791	c.612delA	c.(610-612)aafs	p.K204fs	PLIN2_ENST00000411567.1_Frame_Shift_Del_p.K161fs	NM_001122.3	NP_001113.2	Q99541	PLIN2_HUMAN	perilipin 2	204					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	19						ATCCTTCAACTTTTTTTGCTT	0.428													9	558	---	---	---	---					
SURF6	6838	broad.mit.edu	37	9	136199557	136199557	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr9:136199557delT	ENST00000372022.4	-	4	698	c.433delA	c.(433-435)ggfs	p.R148fs	SURF6_ENST00000468290.1_5'UTR	NM_006753.4	NP_006744.2	O75683	SURF6_HUMAN	surfeit 6	148						granular component	DNA binding|RNA binding			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	12				OV - Ovarian serous cystadenocarcinoma(145;1.16e-06)|Epithelial(140;8.34e-06)|all cancers(34;7.08e-05)		CTCCGCCGCCTTTTCTCCAAG	0.632													8	915	---	---	---	---					
TM9SF3	56889	broad.mit.edu	37	10	98336475	98336475	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr10:98336475delT	ENST00000371142.4	-	2	430	c.214delA	c.(214-216)gtfs	p.S72fs		NM_020123.3	NP_064508.3	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3	72						integral to membrane	binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)	15		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		TGACTGATACTTTTTTTTGAC	0.363													10	322	---	---	---	---					
SLC22A9	114571	broad.mit.edu	37	11	63149668	63149669	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr11:63149668_63149669insA	ENST00000279178.3	+	6	1241_1242	c.992_993insA	c.(991-993)gcafs	p.A331fs	SLC22A9_ENST00000310969.4_3'UTR	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	331					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						CTGGAGGCAGCACAAAAAAAAA	0.406													7	533	---	---	---	---					
PAK1	5058	broad.mit.edu	37	11	77069990	77069992	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr11:77069990_77069992delCAT	ENST00000356341.3	-	6	1079_1081	c.548_550delATG	c.(547-552)gct>g	p.DA183del	PAK1_ENST00000528203.1_In_Frame_Del_p.DA85del|PAK1_ENST00000278568.4_In_Frame_Del_p.DA183del|PAK1_ENST00000525542.1_5'UTR|PAK1_ENST00000530617.1_In_Frame_Del_p.DA183del	NM_002576.4	NP_002567.3	Q13153	PAK1_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 1	183	Interaction with CRIPAK.				apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(13)|skin(2)|stomach(1)	29	all_cancers(14;1.75e-18)					GGTGGGGTAGcatcatcatcatc	0.478													10	328	---	---	---	---					
NOX4	50507	broad.mit.edu	37	11	89106662	89106663	+	Splice_Site	INS	-	-	A	rs56022003		TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr11:89106662_89106663insA	ENST00000535633.1	-	12	1313		c.e12-2		NOX4_ENST00000424319.1_Splice_Site|NOX4_ENST00000528341.1_Splice_Site|NOX4_ENST00000375979.3_Splice_Site|NOX4_ENST00000527626.1_Splice_Site|NOX4_ENST00000263317.4_Splice_Site|NOX4_ENST00000413594.2_Splice_Site|NOX4_ENST00000343727.5_Splice_Site|NOX4_ENST00000527956.1_Splice_Site|NOX4_ENST00000525196.1_Intron|NOX4_ENST00000531342.1_Splice_Site|NOX4_ENST00000542487.1_Splice_Site|NOX4_ENST00000534731.1_Splice_Site|NOX4_ENST00000532825.1_Splice_Site	NM_001143836.1|NM_016931.3	NP_001137308.1|NP_058627.1	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4						cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity	p.?(1)		NS(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(20)|ovary(2)|prostate(3)|skin(2)	44		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				AGTTGGACACTAAAAAAAAATA	0.292													7	454	---	---	---	---					
IFFO1	25900	broad.mit.edu	37	12	6649704	6649706	+	In_Frame_Del	DEL	GGC	GGC	-	rs144019095		TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:6649704_6649706delGGC	ENST00000436152.2	-	11	1273_1275	c.714_716delGCC	c.(712-717)cca>cc	p.PP238del	IFFO1_ENST00000356896.4_In_Frame_Del_p.PP545del|IFFO1_ENST00000465801.1_In_Frame_Del_p.PP237del|IFFO1_ENST00000396840.2_In_Frame_Del_p.PP541del|IFFO1_ENST00000336604.4_In_Frame_Del_p.PP544del			Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan 1	541						intermediate filament				central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	20						AGCCTCGCTTGGCGGCGGCGGCG	0.601													8	684	---	---	---	---					
CHD4	1108	broad.mit.edu	37	12	6711207	6711209	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:6711207_6711209delCTT	ENST00000309577.6	-	4	518_520	c.355_357delAAG	c.(355-357)del	p.K119del	CHD4_ENST00000544040.1_In_Frame_Del_p.K112del|CHD4_ENST00000357008.2_In_Frame_Del_p.K119del|CHD4_ENST00000544484.1_In_Frame_Del_p.K116del			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	119	Poly-Lys.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding	p.K119delK(3)		central_nervous_system(2)	2						TAGGTCCAAGCTTCTTCTTCTTC	0.537													11	227	---	---	---	---					
FAR2	55711	broad.mit.edu	37	12	29450110	29450110	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:29450110delA	ENST00000182377.4	+	4	790	c.522delA	c.(520-522)ccfs	p.P174fs	FAR2_ENST00000536681.2_Frame_Shift_Del_p.P174fs|RP11-996F15.2_ENST00000553105.1_RNA|FAR2_ENST00000547116.1_Frame_Shift_Del_p.P77fs	NM_018099.3	NP_060569.3	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	174					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor			central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|prostate(1)|stomach(1)	29						CTGTGGAGCCAAAAAAAATCA	0.388													11	713	---	---	---	---					
KIF21A	55605	broad.mit.edu	37	12	39727052	39727052	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:39727052delT	ENST00000395670.3	-	18	2868	c.2449delA	c.(2449-2451)gafs	p.R817fs	KIF21A_ENST00000361418.5_Frame_Shift_Del_p.R817fs|KIF21A_ENST00000544797.2_Frame_Shift_Del_p.R804fs|KIF21A_ENST00000541463.2_Intron|KIF21A_ENST00000361961.3_Frame_Shift_Del_p.R804fs			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	817					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				TCTTGGTTTCTTTTTTGGGCT	0.323													8	1246	---	---	---	---					
UTP20	27340	broad.mit.edu	37	12	101680157	101680157	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:101680157delT	ENST00000261637.4	+	5	559	c.385delT	c.(385-387)ttfs	p.F130fs		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	130					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						CTTTCCAGAGTTTTTTTTGAC	0.398													16	1463	---	---	---	---					
SDSL	113675	broad.mit.edu	37	12	113872001	113872001	+	Frame_Shift_Del	DEL	C	C	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:113872001delC	ENST00000403593.4	+	5	679	c.417delC	c.(415-417)gtfs	p.V139fs	SDSL_ENST00000345635.4_Frame_Shift_Del_p.V139fs			Q96GA7	SDSL_HUMAN	serine dehydratase-like	139					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	15					Pyridoxal Phosphate(DB00114)	GGGAGAATGTCCCCCCGTTTG	0.612													7	1481	---	---	---	---					
MPHOSPH9	10198	broad.mit.edu	37	12	123706321	123706322	+	Frame_Shift_Ins	INS	-	-	A			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:123706321_123706322insA	ENST00000606320.1	-	5	675_676	c.469_470insT	c.(469-471)tctfs	p.S157fs	MPHOSPH9_ENST00000539639.1_5'UTR|MPHOSPH9_ENST00000302349.5_Frame_Shift_Ins_p.S5fs|MPHOSPH9_ENST00000392425.3_Frame_Shift_Ins_p.S5fs|MPHOSPH9_ENST00000541076.2_Frame_Shift_Ins_p.S127fs			Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	5					M phase of mitotic cell cycle	centriole|Golgi membrane		p.S5C(1)		NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(18)|prostate(2)|skin(1)	33	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		ACTGCTTAGAGAAAAAAAACCC	0.371													11	537	---	---	---	---					
DDX55	57696	broad.mit.edu	37	12	124103201	124103202	+	Translation_Start_Site	DEL	TG	TG	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr12:124103201_124103202delTG	ENST00000421670.3	+	0	639_640				DDX55_ENST00000541259.1_Intron|DDX55_ENST00000538744.1_Intron|DDX55_ENST00000238146.4_Intron			Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55								ATP binding|ATP-dependent helicase activity|RNA binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		GAATGTGGTATGTGTGTGTGTG	0.520											OREG0022230	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	320	---	---	---	---					
TPTE2	93492	broad.mit.edu	37	13	20041394	20041394	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr13:20041394delA	ENST00000400230.2	-	7	527	c.483delT	c.(481-483)ttfs	p.F161fs	TPTE2_ENST00000400103.2_Intron|TPTE2_ENST00000382975.4_Intron|TPTE2_ENST00000382977.4_Frame_Shift_Del_p.F161fs|TPTE2_ENST00000382978.1_Intron|TPTE2_ENST00000390680.2_Intron|TPTE2_ENST00000255310.6_Intron|TPTE2_ENST00000457266.2_Intron			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	161						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		ACTTAATGTCAAAAAAAATGT	0.303													10	304	---	---	---	---					
CKAP2	0	broad.mit.edu	37	13	53049034	53049034	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr13:53049034delA	ENST00000378037.5	+	9	1900	c.1810delA	c.(1810-1812)aafs	p.K606fs	CKAP2_ENST00000490903.1_Frame_Shift_Del_p.K557fs|CKAP2_ENST00000258607.5_Frame_Shift_Del_p.K605fs	NM_001098525.1|NM_018204.3	NP_001091995.1|NP_060674.3	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2	606					apoptosis|cell cycle	centrosome|microtubule|spindle pole		p.K605fs*14(2)		breast(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(3)|skin(1)|urinary_tract(1)	20		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		TTTCAGTGTGAAAAAAAAGGT	0.318													7	299	---	---	---	---					
RBM26	64062	broad.mit.edu	37	13	79918806	79918807	+	Frame_Shift_Ins	INS	-	-	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr13:79918806_79918807insT	ENST00000438737.2	-	15	2621_2622	c.2181_2182insA	c.(2179-2184)aaaggafs	p.G728fs	RBM26_ENST00000267229.7_Frame_Shift_Ins_p.G701fs|RBM26_ENST00000438724.1_Frame_Shift_Ins_p.G704fs			Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	728					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GTACTTACCTGTTTTTTTTTCT	0.332													10	208	---	---	---	---					
RP11-666E17.1	0	broad.mit.edu	37	14	82284325	82284326	+	RNA	INS	-	-	T			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr14:82284325_82284326insT	ENST00000554814.1	+	0	220																											tccttccttccttcttccttcc	0.520													3	3	---	---	---	---					
SYNE3	161176	broad.mit.edu	37	14	95921888	95921890	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr14:95921888_95921890delCTC	ENST00000334258.5	-	5	975_977	c.961_963delGAG	c.(961-963)del	p.E321del	SYNE3_ENST00000554873.1_In_Frame_Del_p.E78del|SYNE3_ENST00000553340.1_In_Frame_Del_p.E321del|SYNE3_ENST00000557275.1_In_Frame_Del_p.E321del	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						CCCGCAGCCGCTCCTCCTCCTCC	0.616													10	604	---	---	---	---					
SLTM	79811	broad.mit.edu	37	15	59182525	59182526	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr15:59182525_59182526delTC	ENST00000380516.2	-	15	2120_2121	c.2033_2034delGA	c.(2032-2034)afs	p.R678fs	AC025918.2_ENST00000452467.1_RNA|SLTM_ENST00000536328.1_Frame_Shift_Del_p.R247fs	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	678	Arg/Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CGCGTTCCATTCTCTCTCTCTC	0.431													10	655	---	---	---	---					
UBN1	29855	broad.mit.edu	37	16	4910691	4910693	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr16:4910691_4910693delAGA	ENST00000396658.4	+	6	1401_1403	c.698_700delAGA	c.(697-702)gag>g	p.EK233del	UBN1_ENST00000262376.6_In_Frame_Del_p.EK233del|UBN1_ENST00000545171.1_In_Frame_Del_p.EK233del|UBN1_ENST00000590769.1_In_Frame_Del_p.EK233del	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	233	Lys-rich.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity	p.K234E(1)		NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						GCCAGTAAGGAGAAGAAGAAGAA	0.453													8	749	---	---	---	---					
OGFOD1	55239	broad.mit.edu	37	16	56509438	56509439	+	Frame_Shift_Ins	INS	-	-	G	rs147207036	by1000genomes	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr16:56509438_56509439insG	ENST00000566157.1	+	12	1551_1552	c.1428_1429insG	c.(1426-1431)gggtttfs	p.F477fs	OGFOD1_ENST00000568397.1_Frame_Shift_Ins_p.F434fs	NM_018233.3	NP_060703.3	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase domain containing 1	477							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	8					Vitamin C(DB00126)	CAGAATATGGCGGTTTTACTTC	0.371													8	366	---	---	---	---					
RP11-863P13.2	0	broad.mit.edu	37	16	88226611	88226611	+	RNA	DEL	G	G	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr16:88226611delG	ENST00000568587.1	-	0	91																											tggtggtgatggtggtgatgg	0.522													7	25	---	---	---	---					
KDM6B	23135	broad.mit.edu	37	17	7751859	7751861	+	In_Frame_Del	DEL	CAC	CAC	-	rs59627144		TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr17:7751859_7751861delCAC	ENST00000254846.5	+	11	2642_2644	c.2253_2255delCAC	c.(2251-2256)gtc>gt	p.VT751del	KDM6B_ENST00000448097.2_In_Frame_Del_p.VT751del	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	751	Pro-rich.|Thr-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						CTGTCGCCGTcaccaccaccacc	0.650													7	182	---	---	---	---					
PROCA1	147011	broad.mit.edu	37	17	27030601	27030601	+	Frame_Shift_Del	DEL	G	G	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr17:27030601delG	ENST00000301039.2	-	4	1179	c.986delC	c.(985-987)cafs	p.P329fs	PROCA1_ENST00000439862.3_Frame_Shift_Del_p.P331fs	NM_152465.1	NP_689678.1	Q8NCQ7	PRCA1_HUMAN	protein interacting with cyclin A1	357					lipid catabolic process		calcium ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(4)|ovary(1)|urinary_tract(1)	16	Lung NSC(42;0.00431)					GTTTGATCCTGGGGGAGATTT	0.547													7	1095	---	---	---	---					
SEH1L	81929	broad.mit.edu	37	18	12986927	12986929	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr18:12986927_12986929delTCC	ENST00000399892.2	+	9	1238_1240	c.1137_1139delTCC	c.(1135-1140)ctt>ct	p.LP379del	SEH1L_ENST00000262124.11_3'UTR|RP11-773H22.4_ENST00000588211.1_RNA	NM_001013437.1	NP_001013455.1	Q96EE3	SEH1_HUMAN	SEH1-like (S. cerevisiae)	0					attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|carbohydrate metabolic process|cell division|glucose transport|mitotic metaphase plate congression|mitotic prometaphase|mRNA transport|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	11						CCCAGCTCCTtcctcctcctcct	0.522													11	350	---	---	---	---					
FHOD3	80206	broad.mit.edu	37	18	34261459	34261460	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr18:34261459_34261460delAG	ENST00000257209.4	+	12	1493_1494	c.1371_1372delAG	c.(1369-1374)gcagfs	p.AE457fs	FHOD3_ENST00000591635.1_Intron|FHOD3_ENST00000359247.4_Frame_Shift_Del_p.AE457fs|FHOD3_ENST00000445677.1_Frame_Shift_Del_p.AE419fs|FHOD3_ENST00000590592.1_Frame_Shift_Del_p.AE632fs	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	457					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CACTGGCAGCAGAGAGAGAGAG	0.460													13	370	---	---	---	---					
HAUS1	115106	broad.mit.edu	37	18	43685174	43685174	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr18:43685174delA	ENST00000282058.6	+	2	125	c.45delA	c.(43-45)ttfs	p.L15fs	HAUS1_ENST00000585518.1_Frame_Shift_Del_p.L15fs	NM_138443.3	NP_612452.1	Q96CS2	HAUS1_HUMAN	HAUS augmin-like complex, subunit 1	15					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	7						CTGCGTGGTTAAAAAAAATAT	0.393													7	228	---	---	---	---					
TNFRSF11A	8792	broad.mit.edu	37	18	60051988	60051990	+	In_Frame_Del	DEL	TGT	TGT	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr18:60051988_60051990delTGT	ENST00000586569.1	+	10	1610_1612	c.1572_1574delTGT	c.(1570-1575)aag>aa	p.NV524del	TNFRSF11A_ENST00000269485.7_In_Frame_Del_p.NV207del	NM_003839.2	NP_003830.1	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	524					adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(13)|skin(3)|upper_aerodigestive_tract(1)	29		Colorectal(73;0.188)				CCGCAGGAAATGTGACTGGAAAC	0.626													26	103	---	---	---	---					
PNMAL1	55228	broad.mit.edu	37	19	46973195	46973197	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr19:46973195_46973197delCTT	ENST00000313683.10	-	2	1401_1403	c.1096_1098delAAG	c.(1096-1098)del	p.K366del	PNMAL1_ENST00000438932.2_Splice_Site_p.K366_splice|PNMAL1_ENST00000602246.1_Intron	NM_001103149.1|NM_018215.3	NP_001096619.1|NP_060685.2	Q86V59	PNML1_HUMAN	paraneoplastic Ma antigen family-like 1	366										cervix(1)|endometrium(2)|large_intestine(8)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		CCAAGCTCACCTTCTTCTTCTTC	0.562													9	1264	---	---	---	---					
FUZ	80199	broad.mit.edu	37	19	50310483	50310485	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr19:50310483_50310485delCAG	ENST00000313777.4	-	11	1343_1345	c.1180_1182delCTG	c.(1180-1182)del	p.L394del	FUZ_ENST00000533418.1_In_Frame_Del_p.L344del|FUZ_ENST00000445575.2_Intron|FUZ_ENST00000528094.1_In_Frame_Del_p.L358del	NM_025129.4	NP_079405.2	Q9BT04	FUZZY_HUMAN	fuzzy planar cell polarity protein	394	Leu-rich.				cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton				endometrium(1)|lung(3)	4		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		TCTGGGGAGACAGCAGCAGCAGC	0.635													7	311	---	---	---	---					
ZNF577	84765	broad.mit.edu	37	19	52375911	52375911	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr19:52375911delA	ENST00000420592.1	-	6	2488	c.1155delT	c.(1153-1155)ttfs	p.F385fs	ZNF577_ENST00000412216.1_Intron|ZNF577_ENST00000301399.5_Frame_Shift_Del_p.F444fs|ZNF577_ENST00000451628.2_Frame_Shift_Del_p.F385fs|ZNF577_ENST00000485702.1_Intron			Q9BSK1	ZN577_HUMAN	zinc finger protein 577	444					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GATTTCTTGGAAAAGGTTGTT	0.403													93	223	---	---	---	---					
ZNF579	163033	broad.mit.edu	37	19	56089908	56089909	+	In_Frame_Ins	INS	-	-	CCG	rs141478862	by1000genomes	TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr19:56089908_56089909insCCG	ENST00000325421.4	-	2	1125_1126	c.1097_1098insCGG	c.(1096-1098)gca>gCGGca	p.366_366A>AA		NM_152600.2	NP_689813.2	Q8NAF0	ZN579_HUMAN	zinc finger protein 579	366	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G366_Q367insG(1)		endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.106)		CTCCGTTCTGCCCTTCTCCCCC	0.748													13	10	---	---	---	---					
ZNF552	79818	broad.mit.edu	37	19	58319468	58319468	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr19:58319468delT	ENST00000391701.1	-	3	1333	c.1164delA	c.(1162-1164)aafs	p.K388fs	ZNF586_ENST00000599802.1_Intron|ZNF586_ENST00000598885.1_Intron	NM_024762.3	NP_079038.2	Q9H707	ZN552_HUMAN	zinc finger protein 552	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		TTTGCCTAAATTTTTTTTCAC	0.413													7	695	---	---	---	---					
KIF16B	55614	broad.mit.edu	37	20	16488699	16488699	+	Frame_Shift_Del	DEL	A	A	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:16488699delA	ENST00000354981.2	-	7	760	c.603delT	c.(601-603)ctfs	p.L201fs	KIF16B_ENST00000355755.3_Frame_Shift_Del_p.L201fs|KIF16B_ENST00000378003.2_5'UTR|KIF16B_ENST00000408042.1_Frame_Shift_Del_p.L201fs	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	201	Kinesin-motor.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						CCGCATCCATAAGTTCTTCTA	0.433													148	1789	---	---	---	---					
SYNDIG1	79953	broad.mit.edu	37	20	24524183	24524185	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:24524183_24524185delGGA	ENST00000376862.3	+	2	1083_1085	c.450_452delGGA	c.(448-453)gtg>gt	p.VE150del		NM_024893.1	NP_079169.1	Q9H7V2	SYNG1_HUMAN	synapse differentiation inducing 1	150					response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane				breast(2)|endometrium(1)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	24						CCTACGATGTGGAGGAGGAGGAG	0.547													8	1045	---	---	---	---					
CNBD2	140894	broad.mit.edu	37	20	34618504	34618504	+	Frame_Shift_Del	DEL	C	C	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:34618504delC	ENST00000373973.3	+	12	1838	c.1665delC	c.(1663-1665)ctfs	p.L555fs	CNBD2_ENST00000538900.1_3'UTR|CNBD2_ENST00000349339.1_Frame_Shift_Del_p.L551fs					cyclic nucleotide binding domain containing 2																		AGAAATACCTCCCCCCATTGA	0.458													8	3200	---	---	---	---					
CTCFL	140690	broad.mit.edu	37	20	56099187	56099187	+	Frame_Shift_Del	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chr20:56099187delT	ENST00000426658.2	-	1	736	c.75delA	c.(73-75)aafs	p.K25fs	CTCFL_ENST00000423479.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000539382.1_Intron|CTCFL_ENST00000422869.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000432255.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000243914.3_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000371196.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000433949.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000429804.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000502686.2_Intron|CTCFL_ENST00000422109.2_Frame_Shift_Del_p.K25fs			Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	25					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CCTTCAGGCCTTTTTCCGGCA	0.502													15	2148	---	---	---	---					
RP13-228J13.1	0	broad.mit.edu	37	X	154578866	154578866	+	RNA	DEL	T	T	-			TCGA-3A-A9IS-01A-21D-A397-08	TCGA-3A-A9IS-10A-01D-A39A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6adca2bb-c179-4d25-b4c4-52e295b1b984	fa9e0f37-f298-4f1f-af5e-2ddef3f2f935	g.chrX:154578866delT	ENST00000412436.1	-	0	98				RP13-228J13.5_ENST00000453508.1_RNA|RP13-228J13.1_ENST00000444722.1_RNA																							TTTCTCTCTGTTTTTTTTTTT	0.418													7	49	---	---	---	---