Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ACSM5	54988	broad.mit.edu	37	16	20423005	20423005	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr16:20423005G>A	ENST00000331849.4	+	2	346	c.199G>A	c.(199-201)Gaa>Aaa	p.E67K	ACSM5_ENST00000575584.1_Missense_Mutation_p.E67K	NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	67					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						GAGTCGGCTGGAAGAGGTGAA	0.557000													5	222					0	0	1	0	0
SHOX	6473	broad.mit.edu	37	X	591887	591887	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chrX:591887C>T	ENST00000381578.1	+	2	946	c.255C>T	c.(253-255)ttC>ttT	p.F85F	SHOX_ENST00000334060.3_Silent_p.F85F|SHOX_ENST00000554971.1_Silent_p.F85F|SHOX_ENST00000381575.1_Silent_p.F85F	NM_000451.3	NP_000442.1	O15266	SHOX_HUMAN	short stature homeobox	85					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(9)|prostate(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGAAAGAATTCGGCACCGCGA	0.642000													11	354					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	55733472	55733472	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:55733472G>A	ENST00000288221.6	-	16	3036	c.2781C>T	c.(2779-2781)caC>caT	p.H927H		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	927	Poly-His.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		ggtggtgatggtggtggtggt	0.507000													6	701					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2938676	2938676	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:2938676G>A	ENST00000378404.2	+	1	631	c.426G>A	c.(424-426)gcG>gcA	p.A142A		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	142						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		CGGACCAGGCGGTGCTGGCTC	0.622000													7	203					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628299	29628299	+	Missense_Mutation	SNP	A	A	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr20:29628299A>G	ENST00000278882.3	+	6	681	c.301A>G	c.(301-303)Agt>Ggt	p.S101G	FRG1B_ENST00000439954.2_Missense_Mutation_p.S106G|FRG1B_ENST00000358464.4_Missense_Mutation_p.S101G																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AGAAGCAAAAAGTAAAACAGC	0.363000													10	397					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158262587	158262587	+	Missense_Mutation	SNP	C	C	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:158262587C>G	ENST00000296526.7	+	12	2341	c.2016C>G	c.(2014-2016)gaC>gaG	p.D672E	GRIA2_ENST00000393815.2_Missense_Mutation_p.D625E|GRIA2_ENST00000264426.9_Missense_Mutation_p.D672E|GRIA2_ENST00000449365.1_Missense_Mutation_p.D625E|GRIA2_ENST00000507898.1_Missense_Mutation_p.D625E	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	672					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	GAACATTAGACTCTGGCTCCA	0.398000													8	562					0	0	1	0	0
WDR6	11180	broad.mit.edu	37	3	49051722	49051722	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:49051722G>A	ENST00000395474.3	+	3	3032	c.2752G>A	c.(2752-2754)Gta>Ata	p.V918I	WDR6_ENST00000448293.1_Missense_Mutation_p.V837I|WDR6_ENST00000415265.2_Missense_Mutation_p.V336I	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	888					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		TGATGGGGCCGTAAGGTGAGA	0.597000											OREG0015565	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	214					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19473538	19473538	+	Missense_Mutation	SNP	C	C	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:19473538C>A	ENST00000507958.1	-	15	3160	c.2170G>T	c.(2170-2172)Gac>Tac	p.D724Y	CDH18_ENST00000274170.4_Missense_Mutation_p.D724Y|CDH18_ENST00000510297.1_5'UTR|CDH18_ENST00000382275.1_Missense_Mutation_p.D724Y			Q13634	CAD18_HUMAN	cadherin 18, type 2	724					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GGGTCTAGGTCTGCTTCTGCC	0.483000													8	267					0.0381472	0.0382498	1	1	0
MMEL1	79258	broad.mit.edu	37	1	2528091	2528091	+	Missense_Mutation	SNP	C	C	T	rs150030274		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:2528091C>T	ENST00000288709.6	-	14	1523	c.1283G>A	c.(1282-1284)cGt>cAt	p.R428H	MMEL1_ENST00000502556.1_Missense_Mutation_p.R280H|MMEL1_ENST00000378412.3_Missense_Mutation_p.R437H	NM_033467.3	NP_258428.2	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	437					proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity			cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|urinary_tract(1)	27	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CACACATTCACGCCAGCGCAC	0.662000													12	245					0	0	1	0	0
REG1A	5967	broad.mit.edu	37	2	79348754	79348754	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:79348754G>A	ENST00000233735.1	+	3	234	c.131G>A	c.(130-132)cGc>cAc	p.R44H		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	44	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding	p.R44H(1)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						AATGCCTATCGCTCCTACTGC	0.537000													27	735					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75898211	75898211	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:75898211G>A	ENST00000322507.8	-	8	1173	c.864C>T	c.(862-864)gcC>gcT	p.A288A	COL12A1_ENST00000345356.6_Intron|COL12A1_ENST00000483888.2_Silent_p.A288A|COL12A1_ENST00000416123.2_Silent_p.A288A	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	288	VWFA 1.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						AAGGTGTGGAGGCAATTTGTT	0.408000													10	381					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175293512	175293512	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:175293512C>T	ENST00000367674.1	-	22	4645	c.3937G>A	c.(3937-3939)Ggg>Agg	p.G1313R	RP3-518E13.2_ENST00000569593.1_RNA|TNR_ENST00000263525.2_Missense_Mutation_p.G1313R	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	1313	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					CTGGACTCCCCGTACTTCCCA	0.498000													19	112					0	0	1	0	0
SLC9A3	6550	broad.mit.edu	37	5	476448	476448	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:476448C>T	ENST00000264938.3	-	13	1945	c.1936G>A	c.(1936-1938)Gag>Aag	p.E646K	CTD-2228K2.7_ENST00000606319.1_RNA|SLC9A3_ENST00000514375.1_Missense_Mutation_p.E637K|CTD-2228K2.7_ENST00000607286.1_RNA	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	646	Interaction with PDZD3 (By similarity).					cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			TCCTGTTTCTCGTCCTCCGTG	0.612000													106	426					0	0	1	0	0
GTF2IRD2P1	0	broad.mit.edu	37	7	72663998	72663998	+	RNA	SNP	T	T	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:72663998T>G	ENST00000425256.1	-	0	902					NR_002164.1																						ATAGCCGGGGTCCTTGAATAC	0.488000													6	351					0	0	1	0	0
EML4	27436	broad.mit.edu	37	2	42531673	42531673	+	Missense_Mutation	SNP	T	T	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:42531673T>A	ENST00000318522.5	+	17	2211	c.1949T>A	c.(1948-1950)aTa>aAa	p.I650K	EML4_ENST00000453191.2_5'UTR|EML4_ENST00000402711.2_Missense_Mutation_p.I592K|EML4_ENST00000401738.3_Missense_Mutation_p.I661K	NM_019063.3	NP_061936.2	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	650					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(543)	NS(2)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	12						GTGGTGGCCATAGGAACGCAC	0.458000			T	ALK	NSCLC								177	241					0	0	1	0	0
TUBB8	347688	broad.mit.edu	37	10	94582	94582	+	Missense_Mutation	SNP	C	C	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr10:94582C>A	ENST00000447903.2	-	3	349	c.34G>T	c.(34-36)Gtc>Ttc	p.V12F	TUBB8_ENST00000332708.5_Missense_Mutation_p.R47S|TUBB8_ENST00000413237.3_5'UTR|TUBB8_ENST00000309812.4_Missense_Mutation_p.V84F			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	84					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		GGCCTGAAGACCTGCCCGAAG	0.662000													5	189					1.26484e-09	1.34412e-09	1	1	0
ATP10D	57205	broad.mit.edu	37	4	47578836	47578836	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:47578836C>T	ENST00000273859.3	+	19	3682	c.3413C>T	c.(3412-3414)tCa>tTa	p.S1138L		NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1138					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						TGTGGATTTTCAGGAACATCC	0.413000													378	794					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71490089	71490089	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:71490089C>T	ENST00000296755.7	+	5	1205	c.907C>T	c.(907-909)Cga>Tga	p.R303*		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	303						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		ACACTTAGACCGAGTGGACTC	0.483000													238	261					0	0	1	0	0
PCDHGA2	0	broad.mit.edu	37	5	140720485	140720485	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:140720485C>T	ENST00000394576.2	+	1	1947	c.1947C>T	c.(1945-1947)caC>caT	p.H649H	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCAGGACCACGGCCAGCCCC	0.706000													32	812					0	0	1	0	0
CHST11	50515	broad.mit.edu	37	12	105150785	105150785	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:105150785C>T	ENST00000303694.5	+	3	702	c.263C>T	c.(262-264)aCg>aTg	p.T88M	CHST11_ENST00000549260.1_Missense_Mutation_p.T83M	NM_018413.5	NP_060883.1	Q9NPF2	CHSTB_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 11	88					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)	18						GTGACAGACACGTGCCGAGCC	0.587000													6	196					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155301425	155301425	+	Missense_Mutation	SNP	C	C	T	rs143246976	by1000genomes	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:155301425C>T	ENST00000460012.1	-	6	874	c.517G>A	c.(517-519)Gac>Aac	p.D173N	PLCH1_ENST00000334686.6_Missense_Mutation_p.D173N|PLCH1_ENST00000447496.2_Missense_Mutation_p.D191N|PLCH1_ENST00000414191.1_Missense_Mutation_p.D173N|PLCH1_ENST00000494598.1_Missense_Mutation_p.D191N|PLCH1_ENST00000340059.7_Missense_Mutation_p.D191N			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	191	EF-hand 1.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCATCTGTGTCGGCTTCCTGA	0.323000													10	217					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137622301	137622301	+	Missense_Mutation	SNP	G	G	A	rs148288567		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:137622301G>A	ENST00000371817.3	+	7	1558	c.1144G>A	c.(1144-1146)Gac>Aac	p.D382N		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	382	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CAGCACCGCCGACACCTCCAA	0.622000													15	315					0	0	1	0	0
ZKSCAN3	80317	broad.mit.edu	37	6	28329181	28329181	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:28329181C>T	ENST00000377255.3	+	4	780	c.483C>T	c.(481-483)agC>agT	p.S161S	ZKSCAN3_ENST00000252211.2_Silent_p.S161S|ZKSCAN3_ENST00000341464.5_Silent_p.S13S	NM_001242894.1	NP_001229823.1	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	161					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(8)|pancreas(1)|skin(2)|stomach(2)|urinary_tract(1)	21						CACAAAGTAGCCAATTTCAGC	0.438000													92	185					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75113416	75113416	+	Splice_Site	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr15:75113416G>A	ENST00000309664.5	+	9	1047	c.907_splice	c.e9-1	p.G303_splice	LMAN1L_ENST00000379709.3_Splice_Site_p.G291_splice|RP11-414J4.2_ENST00000564823.1_RNA	NM_021819.2	NP_068591.2	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	303						ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TAATCCCCAGGGGAAAGGCTC	0.617000													13	11					0	0	1	0	0
CCDC71	64925	broad.mit.edu	37	3	49200839	49200839	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:49200839C>T	ENST00000321895.6	-	2	909	c.803G>A	c.(802-804)cGg>cAg	p.R268Q		NM_022903.3	NP_075054.3	Q8IV32	CCD71_HUMAN	coiled-coil domain containing 71	268										endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	10				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TTTCATTCGCCGGACACTGGG	0.642000													10	443					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16945409	16945409	+	RNA	SNP	T	T	A	rs13566		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:16945409T>A	ENST00000412962.1	-	0	2110																											GCGGGATAGCTCGGTGGAGAG	0.612000													12	129					0	0	1	0	0
PIK3R1	5295	broad.mit.edu	37	5	67589652	67589652	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:67589652G>A	ENST00000521381.1	+	11	2031	c.1415G>A	c.(1414-1416)cGc>cAc	p.R472H	PIK3R1_ENST00000336483.5_Missense_Mutation_p.R202H|PIK3R1_ENST00000523872.1_Missense_Mutation_p.R109H|PIK3R1_ENST00000521657.1_Missense_Mutation_p.R472H|PIK3R1_ENST00000274335.5_Missense_Mutation_p.R472H|PIK3R1_ENST00000320694.8_Missense_Mutation_p.R172H|PIK3R1_ENST00000396611.1_Missense_Mutation_p.R472H	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	472					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D434_Q475del(1)|p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	GAATATACCCGCACATCCCAG	0.279000			"""Mis, F, O"""		"""gliobastoma, ovarian, colorectal"""					TCGA GBM(4;<1E-08)			5	379					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100350474	100350474	+	RNA	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:100350474T>C	ENST00000542585.1	+	0	2894				ZAN_ENST00000349350.6_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane		p.S916P(2)		NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACCCACCATCTCCACGGAAAA	0.502000													10	1088					0	0	1	0	0
C6orf118	168090	broad.mit.edu	37	6	165715541	165715541	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:165715541G>A	ENST00000230301.8	-	2	290	c.270C>T	c.(268-270)cgC>cgT	p.R90R	C6orf118_ENST00000543069.1_5'UTR	NM_144980.3	NP_659417.2	Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	90								p.R90R(1)		breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CCTCAGAGGCGCGCTCCCCCT	0.657000													184	120					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121033012	121033012	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:121033012C>T	ENST00000392793.1	+	16	5476	c.5205C>T	c.(5203-5205)gcC>gcT	p.A1735A	TECTA_ENST00000264037.2_Silent_p.A1735A			O75443	TECTA_HUMAN	tectorin alpha	1735					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCTCCCTGGCCGCCTACGGGG	0.547000													27	131					0	0	1	0	0
TMEM199	147007	broad.mit.edu	37	17	26685942	26685942	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr17:26685942C>T	ENST00000292114.3	+	2	305	c.215C>T	c.(214-216)tCc>tTc	p.S72F	CTB-96E2.3_ENST00000591482.1_RNA|TMEM199_ENST00000395404.3_Intron|TMEM199_ENST00000509083.1_Missense_Mutation_p.S72F|TMEM199_ENST00000581386.1_3'UTR	NM_152464.1	NP_689677.1	Q8N511	TM199_HUMAN	transmembrane protein 199	72						integral to membrane				endometrium(1)|kidney(2)|large_intestine(1)|lung(2)	6	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		TTCTCAGATTCCAAACTATAC	0.438000													11	211					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14543062	14543062	+	Silent	SNP	A	A	G	rs45469106		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr18:14543062A>G	ENST00000358970.5	-	1	83	c.84T>C	c.(82-84)ttT>ttC	p.F28F	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	28			F -> C (in dbSNP:rs45626231).							NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						AGCGGTGGTGAAACCACTTGC	0.547000													8	596					0	0	1	0	0
TAS2R1	50834	broad.mit.edu	37	5	9629468	9629468	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:9629468G>A	ENST00000382492.2	-	1	995	c.677C>T	c.(676-678)gCg>gTg	p.A226V	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	226					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						AGACAGCAACGCGCTGATGGG	0.498000													6	256					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76753947	76753947	+	Silent	SNP	G	G	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr18:76753947G>T	ENST00000536229.3	+	1	2266	c.1557G>T	c.(1555-1557)ctG>ctT	p.L519L	SALL3_ENST00000575389.2_Silent_p.L652L|SALL3_ENST00000537592.2_Silent_p.L652L			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	652					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		TCGGGGGGCTGCTAGACTCGA	0.642000													8	61					0.000157383	0.000162166	1	1	0
GON4L	54856	broad.mit.edu	37	1	155774905	155774905	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:155774905G>A	ENST00000437809.1	-	11	1602	c.1480C>T	c.(1480-1482)Cga>Tga	p.R494*	GON4L_ENST00000271883.5_Nonsense_Mutation_p.R494*|GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000368331.1_Nonsense_Mutation_p.R494*|GON4L_ENST00000361040.5_Nonsense_Mutation_p.R494*			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	494					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GAACGCGTTCGAAATGCAATG	0.468000													12	352					0	0	1	0	0
FAM129B	64855	broad.mit.edu	37	9	130269516	130269516	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:130269516G>A	ENST00000373312.3	-	14	2062	c.1849C>T	c.(1849-1851)Cgg>Tgg	p.R617W	FAM129B_ENST00000373314.3_Missense_Mutation_p.R604W|FAM129B_ENST00000468379.1_5'UTR	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B	617							protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						TTGGCGCGCCGTCGCTTTTCC	0.701000													9	150					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													7	143					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25924815	25924815	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr15:25924815C>T	ENST00000356865.6	-	21	4284	c.4173G>A	c.(4171-4173)ccG>ccA	p.P1391P		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1391					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		ACATGGGGGCCGGTGCGCTCA	0.687000													17	211					0	0	1	0	0
RAD17	5884	broad.mit.edu	37	5	68709938	68709938	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:68709938G>A	ENST00000509734.1	+	18	2543	c.1865G>A	c.(1864-1866)gGa>gAa	p.G622E	RAD17_ENST00000345306.6_Missense_Mutation_p.G611E|RAD17_ENST00000354868.5_Missense_Mutation_p.G611E|RAD17_ENST00000521422.1_Missense_Mutation_p.G446E|RAD17_ENST00000504177.1_3'UTR|RAD17_ENST00000354312.3_Missense_Mutation_p.G611E|RAD17_ENST00000358030.2_Missense_Mutation_p.G446E|RAD17_ENST00000305138.4_Missense_Mutation_p.G611E|RAD17_ENST00000282891.6_Missense_Mutation_p.G525E|RAD17_ENST00000361732.2_Missense_Mutation_p.G611E|RAD17_ENST00000380774.3_Missense_Mutation_p.G622E			O75943	RAD17_HUMAN	RAD17 homolog (S. pombe)	622	Interaction with MCM7.				cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding						Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		CTTAATGGAGGACATTCTGCA	0.507000								Other conserved DNA damage response genes					6	624					0	0	1	0	0
ELFN1	392617	broad.mit.edu	37	7	1785967	1785967	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:1785967G>A	ENST00000424383.2	+	3	2222	c.1735G>A	c.(1735-1737)Gag>Aag	p.E579K	ELFN1_ENST00000561626.1_Missense_Mutation_p.E579K|ELFN1_ENST00000541472.1_Missense_Mutation_p.E557K					extracellular leucine-rich repeat and fibronectin type III domain containing 1											endometrium(1)	1						GCTCAAGTCCGAGTCCACCTC	0.657000													15	19					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101824552	101824552	+	Missense_Mutation	SNP	C	C	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:101824552C>A	ENST00000375001.3	+	38	3980	c.3557C>A	c.(3556-3558)gCc>gAc	p.A1186D		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	1186	Nonhelical region 10 (NC10).			Missing (in Ref. 2; AAC78500).	angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				CCCATTCCTGCCGACAGCCCT	0.443000													7	366					2.74318e-10	2.93182e-10	1	1	0
RXFP3	51289	broad.mit.edu	37	5	33937967	33937967	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:33937967C>T	ENST00000330120.3	+	1	1477	c.1122C>T	c.(1120-1122)agC>agT	p.S374S		NM_016568.3	NP_057652.1	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	374						integral to plasma membrane	N-formyl peptide receptor activity			endometrium(4)|large_intestine(9)|lung(24)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)	42						TCCCTGTGAGCGTGTGCCTAG	0.622000													27	527					0	0	1	0	0
TRIM67	440730	broad.mit.edu	37	1	231337128	231337128	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:231337128G>A	ENST00000444294.3	+	5	2257	c.1399G>A	c.(1399-1401)Gtc>Atc	p.V467I	TRIM67_ENST00000366652.2_Missense_Mutation_p.V467I|TRIM67_ENST00000366653.5_Missense_Mutation_p.V467I|TRIM67_ENST00000449018.3_Missense_Mutation_p.V405I	NM_001004342.3	NP_001004342.3	Q6ZTA4	TRI67_HUMAN	tripartite motif containing 67	467	COS.					cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				GATCAAGCGCGTCCAGGTGTC	0.532000													50	43					0	0	1	0	0
ATL2	64225	broad.mit.edu	37	2	38536594	38536594	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:38536594G>A	ENST00000378954.4	-	9	999	c.998C>T	c.(997-999)gCc>gTc	p.A333V	ATL2_ENST00000546051.1_Missense_Mutation_p.A162V|ATL2_ENST00000406122.1_Missense_Mutation_p.A162V|ATL2_ENST00000539122.1_Missense_Mutation_p.A162V|ATL2_ENST00000452935.2_Missense_Mutation_p.A315V|ATL2_ENST00000332337.4_Missense_Mutation_p.A315V|ATL2_ENST00000402054.1_Missense_Mutation_p.A162V|ATL2_ENST00000419554.2_Missense_Mutation_p.A333V	NM_001135673.1|NM_022374.2	NP_001129145.1|NP_071769.2	Q8NHH9	ATLA2_HUMAN	atlastin GTPase 2	333					endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22						ATTTTCAGGGGCAAGCAGCAA	0.333000													5	388					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54604068	54604068	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:54604068G>A	ENST00000474759.1	+	8	873	c.825G>A	c.(823-825)gcG>gcA	p.A275A	CACNA2D3_ENST00000415676.2_Silent_p.A275A|CACNA2D3_ENST00000490478.1_Silent_p.A181A|CACNA2D3_ENST00000288197.5_Silent_p.A275A	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	275	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TGACTATCGCGAAGCAAACAG	0.473000													12	599					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104640413	104640413	+	Missense_Mutation	SNP	C	C	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:104640413C>A	ENST00000304883.2	-	1	560	c.420G>T	c.(418-420)ttG>ttT	p.L140F		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	140						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		TGAAATTGACCAACGTGTTGA	0.532000													6	229					5.18039e-06	5.42777e-06	1	1	0
APOB	338	broad.mit.edu	37	2	21250863	21250863	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:21250863C>T	ENST00000233242.1	-	14	2031	c.1904G>A	c.(1903-1905)cGg>cAg	p.R635Q	APOB_ENST00000399256.4_Missense_Mutation_p.R635Q	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	635	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTGATAGTTCCGAGAGAATTT	0.363000													119	437					0	0	1	0	0
ACTL7A	10881	broad.mit.edu	37	9	111625720	111625720	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:111625720G>A	ENST00000333999.3	+	1	1118	c.1118G>A	c.(1117-1119)cGt>cAt	p.R373H		NM_006687.2	NP_006678.1	Q9Y615	ACL7A_HUMAN	actin-like 7A	373						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						TTCCCTAACCGTCTGCAGAAG	0.587000													130	174					0	0	1	0	0
DBC1	0	broad.mit.edu	37	9	121930086	121930086	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:121930086C>T	ENST00000265922.3	-	8	2023	c.1562G>A	c.(1561-1563)cGc>cAc	p.R521H	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		521					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						CATGCGCTTGCGCCACCGAGG	0.562000													5	184					0	0	1	0	0
CCT6P1	0	broad.mit.edu	37	7	65222986	65222986	+	RNA	SNP	G	G	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:65222986G>T	ENST00000442266.1	+	0	578																											GAATTCTGGCGTTTTTTACAA	0.289000													5	119					0.000157383	0.000162166	1	1	0
PAX8	7849	broad.mit.edu	37	2	114002064	114002064	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:114002064C>T	ENST00000429538.3	-	4	523	c.329G>A	c.(328-330)cGg>cAg	p.R110Q	AC016683.6_ENST00000556070.1_RNA|AC016683.6_ENST00000553869.2_RNA|PAX8_ENST00000397647.3_Missense_Mutation_p.R110Q|AC016683.6_ENST00000422956.1_RNA|PAX8_ENST00000348715.5_Missense_Mutation_p.R110Q|PAX8_ENST00000263335.7_Missense_Mutation_p.R110Q|AC016683.6_ENST00000451179.1_RNA|AC016683.6_ENST00000445745.1_RNA|AC016683.6_ENST00000436293.2_RNA|PAX8_ENST00000263334.5_Missense_Mutation_p.R110Q|AC016683.6_ENST00000333145.5_RNA	NM_003466.3	NP_003457.1	Q06710	PAX8_HUMAN	paired box 8	110	Paired.				branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity		PAX8/PPARG(117)	breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|skin(1)	20						AGCCAGGAGCCGGTCTCGGAT	0.597000			T	PPARG	follicular thyroid		Thyroid dysgenesis						11	1010					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2816009	2816009	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr16:2816009G>A	ENST00000301740.8	+	11	6029	c.5480G>A	c.(5479-5481)cGg>cAg	p.R1827Q		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	1827	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						TCACCTGCCCGGCAGGAAAGT	0.652000													5	174					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55739269	55739269	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:55739269G>A	ENST00000370830.3	-	1	1093	c.395C>T	c.(394-396)aCg>aTg	p.T132M	BMP5_ENST00000446683.2_Missense_Mutation_p.T132M	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	132					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			CAGAGGAGTCGTCCGAGATAA	0.512000													18	261					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113711433	113711433	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:113711433G>A	ENST00000003302.4	-	5	489	c.421C>T	c.(421-423)Cgc>Tgc	p.R141C	USP28_ENST00000545540.1_Missense_Mutation_p.R16C|USP28_ENST00000260188.5_Missense_Mutation_p.R141C|USP28_ENST00000542033.1_5'UTR|USP28_ENST00000537706.1_Missense_Mutation_p.R141C	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	141					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		ACTTCACAGCGTTTTCTCTTT	0.423000													6	281					0	0	1	0	0
DHX15	1665	broad.mit.edu	37	4	24543566	24543566	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:24543566C>T	ENST00000336812.4	-	8	1571	c.1415G>A	c.(1414-1416)cGa>cAa	p.R472Q		NM_001358.2	NP_001349.2	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 15	472	Helicase C-terminal.				mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	30		Breast(46;0.0503)				ACGTCCAGCTCGACCAGCCCT	0.433000													6	411					0	0	1	0	0
HOXD3	3232	broad.mit.edu	37	2	177036748	177036748	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:177036748G>A	ENST00000468418.3	+	4	3135	c.1045G>A	c.(1045-1047)Gcc>Acc	p.A349T	HOXD3_ENST00000249440.3_Missense_Mutation_p.A349T|HOXD3_ENST00000410016.1_Missense_Mutation_p.A349T			P31249	HXD3_HUMAN	homeobox D3	349					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		CTTCGCCAGCGCCAACTTGCA	0.697000													19	49					0	0	1	0	0
SBSN	374897	broad.mit.edu	37	19	36019170	36019170	+	Missense_Mutation	SNP	C	C	T	rs138249808		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:36019170C>T	ENST00000452271.2	-	1	42	c.14G>A	c.(13-15)cGt>cAt	p.R5H	SBSN_ENST00000518157.1_Missense_Mutation_p.R5H	NM_001166034.1	NP_001159506.1	Q6UWP8	SBSN_HUMAN	suprabasin	5						extracellular region				large_intestine(5)|lung(6)|ovary(1)|prostate(2)	14	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCCGACCAGACGTGCAAGATG	0.587000													5	125					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26881445	26881445	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:26881445C>T	ENST00000231021.4	-	12	2342	c.2170G>A	c.(2170-2172)Gac>Aac	p.D724N		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	724					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						GGGTCTGCGTCGTTTTCTTTT	0.418000													27	458					0	0	1	0	0
IQGAP1	8826	broad.mit.edu	37	15	90997745	90997745	+	Missense_Mutation	SNP	G	G	A	rs147346534		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr15:90997745G>A	ENST00000268182.5	+	14	1697	c.1573G>A	c.(1573-1575)Gtg>Atg	p.V525M	IQGAP1_ENST00000560738.1_Intron	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	525					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			CCAAGCTTGCGTGGACCATGT	0.453000													6	382					0	0	1	0	0
ABTB2	25841	broad.mit.edu	37	11	34218997	34218997	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:34218997C>T	ENST00000435224.2	-	3	1543	c.1119G>A	c.(1117-1119)ccG>ccA	p.P373P	ABTB2_ENST00000298992.2_Silent_p.P187P|ABTB2_ENST00000530814.1_5'UTR	NM_145804.2	NP_665803.2	A8K6S9	A8K6S9_HUMAN	ankyrin repeat and BTB (POZ) domain containing 2	187							DNA binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				TGGGCTGTGGCGGCTGGCGGG	0.687000													4	122					0	0	1	0	0
FOLH1B	219595	broad.mit.edu	37	11	89395322	89395322	+	RNA	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:89395322C>T	ENST00000532352.1	+	0	720							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						TTTCAGAATACGCTTATAGGC	0.343000													4	101					0	0	1	0	0
KSR1	8844	broad.mit.edu	37	17	25783764	25783764	+	Missense_Mutation	SNP	C	C	T	rs79564666	by1000genomes	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr17:25783764C>T	ENST00000319524.6	+	1	95	c.95C>T	c.(94-96)gCc>gTc	p.A32V	KSR1_ENST00000509603.2_Missense_Mutation_p.A32V			Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	30					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		GGCGCAGGGGCCGCGGCCAGC	0.736000													7	51					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34286094	34286094	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:34286094C>T	ENST00000373381.4	-	8	1351	c.1175G>A	c.(1174-1176)gGc>gAc	p.G392D		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	352	Sushi 2.					integral to membrane|plasma membrane	protein binding	p.G352D(1)		NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TAGTCTTTTGCCCCTTTCGGG	0.463000													7	721					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150164276	150164276	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:150164276C>T	ENST00000307271.3	+	2	1064	c.490C>T	c.(490-492)Cga>Tga	p.R164*		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	164						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CTATGAGGGCCGATACTGCAT	0.443000													6	712					0	0	1	0	0
DHX37	57647	broad.mit.edu	37	12	125435335	125435335	+	Missense_Mutation	SNP	C	C	T	rs140554912		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:125435335C>T	ENST00000308736.2	-	22	2982	c.2884G>A	c.(2884-2886)Gac>Aac	p.D962N	DHX37_ENST00000544745.1_Missense_Mutation_p.D749N	NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	962							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		AAGACAGGGTCGTCGAGGAGA	0.532000													47	213					0	0	1	0	0
VN1R4	317703	broad.mit.edu	37	19	53770069	53770069	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:53770069C>T	ENST00000311170.4	-	1	903	c.850G>A	c.(850-852)Gtt>Att	p.V284I		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	284					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		CTCATGAGAACAAAGGGGCTG	0.393000										HNSCC(26;0.072)			5	294					0	0	1	0	0
DMKN	93099	broad.mit.edu	37	19	36000839	36000839	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:36000839G>A	ENST00000339686.3	-	7	1188	c.1012C>T	c.(1012-1014)Cgc>Tgc	p.R338C	DMKN_ENST00000424570.2_Missense_Mutation_p.R338C|DMKN_ENST00000440396.1_Missense_Mutation_p.R338C|DMKN_ENST00000467637.1_Missense_Mutation_p.R51C|DMKN_ENST00000461300.1_Intron|DMKN_ENST00000392206.2_Missense_Mutation_p.R51C|DMKN_ENST00000447113.2_Missense_Mutation_p.R338C|DMKN_ENST00000480502.1_Missense_Mutation_p.R51C|DMKN_ENST00000419602.1_Missense_Mutation_p.R277C|DMKN_ENST00000414866.2_Missense_Mutation_p.R51C|DMKN_ENST00000458071.1_Missense_Mutation_p.R51C|DMKN_ENST00000472252.2_Intron|DMKN_ENST00000436012.1_Intron|DMKN_ENST00000451297.2_Intron|DMKN_ENST00000492341.2_Intron|DMKN_ENST00000474928.1_5'UTR|DMKN_ENST00000488892.1_Intron|DMKN_ENST00000429837.1_Missense_Mutation_p.R277C|DMKN_ENST00000443640.1_Missense_Mutation_p.R51C|DMKN_ENST00000462126.1_Intron|DMKN_ENST00000402589.2_Missense_Mutation_p.R51C|DMKN_ENST00000418261.1_Missense_Mutation_p.R338C|DMKN_ENST00000602781.1_Missense_Mutation_p.R51C	NM_033317.4	NP_201574.3	Q6E0U4	DMKN_HUMAN	dermokine	338	Gly-rich.					extracellular region				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(2)	27	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CCGCTCCCGCGGGCTTCATTC	0.582000											OREG0025431	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	321					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128842373	128842373	+	Missense_Mutation	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:128842373T>C	ENST00000310343.9	-	21	3985	c.3986A>G	c.(3985-3987)aAt>aGt	p.N1329S	ARHGAP32_ENST00000392657.3_Missense_Mutation_p.N980S|ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.N980S	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1329					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						TAATCCTATATTGGTTGCTGC	0.478000													31	419					0	0	1	0	0
CYP2E1	1571	broad.mit.edu	37	10	135345639	135345639	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr10:135345639G>A	ENST00000463117.2	+	6	771	c.499G>A	c.(499-501)Gac>Aac	p.D167N	SPRN_ENST00000541506.1_Intron|CYP2E1_ENST00000252945.3_Missense_Mutation_p.D167N|CYP2E1_ENST00000480558.1_3'UTR			P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E, polypeptide 1	167					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			NS(1)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(7)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	CCAGCCTTTCGACCCCACCTT	0.552000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				10	565					0	0	1	0	0
POP4	10775	broad.mit.edu	37	19	30099608	30099608	+	Missense_Mutation	SNP	G	G	A	rs144806266		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:30099608G>A	ENST00000585603.1	+	2	2354	c.52G>A	c.(52-54)Gat>Aat	p.D18N	POP4_ENST00000392279.3_Silent_p.P11P|POP4_ENST00000591824.1_3'UTR|POP4_ENST00000221770.3_De_novo_Start_InFrame			O95707	RPP29_HUMAN	processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)	18					mRNA cleavage|rRNA processing|tRNA processing	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease P activity|RNA binding	p.D18Y(1)		breast(1)|endometrium(1)|lung(4)	6	Ovarian(5;0.000567)|Breast(6;0.0602)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0623)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.225)			GAATGACTCCGATGTCCAGGT	0.488000													15	426					0	0	1	0	0
PCDHGA4	0	broad.mit.edu	37	5	140734992	140734992	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:140734992C>T	ENST00000571252.1	+	1	225	c.225C>T	c.(223-225)ttC>ttT	p.F75F	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCAGCTTTTCGCCCTGAACC	0.637000													11	532					0	0	1	0	0
KDM4C	23081	broad.mit.edu	37	9	6980958	6980958	+	Missense_Mutation	SNP	A	A	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:6980958A>G	ENST00000381309.3	+	9	1520	c.955A>G	c.(955-957)Atg>Gtg	p.M319V	KDM4C_ENST00000428870.2_Missense_Mutation_p.M6V|KDM4C_ENST00000536108.1_Missense_Mutation_p.M138V|KDM4C_ENST00000543771.1_Missense_Mutation_p.M319V|KDM4C_ENST00000381306.3_Missense_Mutation_p.M319V|KDM4C_ENST00000442236.2_Missense_Mutation_p.M138V|KDM4C_ENST00000535193.1_Missense_Mutation_p.M341V	NM_015061.3	NP_055876.2	Q9H3R0	KDM4C_HUMAN	lysine (K)-specific demethylase 4C	319					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43						GAAGATTTCAATGGATATCTT	0.423000													171	183					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9578330	9578330	+	Silent	SNP	G	G	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:9578330G>T	ENST00000301480.4	-	10	1506	c.1293C>A	c.(1291-1293)acC>acA	p.T431T		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	431					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						CACATTTAAAGGTTTTCTCTC	0.413000													5	284					0.000602214	0.000613732	1	1	0
HEPACAM	220296	broad.mit.edu	37	11	124793759	124793759	+	Missense_Mutation	SNP	C	C	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:124793759C>A	ENST00000298251.4	-	3	980	c.575G>T	c.(574-576)aGa>aTa	p.R192I		NM_152722.4	NP_689935.2	Q14CZ8	HECAM_HUMAN	hepatic and glial cell adhesion molecule	192	Ig-like C2-type.				cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		CAGGAGCATTCTCGAGTCATT	0.582000													13	100					0.00010058	0.000104212	1	1	0
TCF20	6942	broad.mit.edu	37	22	42605760	42605760	+	Missense_Mutation	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr22:42605760T>C	ENST00000359486.3	-	1	5688	c.5552A>G	c.(5551-5553)gAa>gGa	p.E1851G	TCF20_ENST00000335626.4_Missense_Mutation_p.E1851G|TCF20_ENST00000404876.1_Missense_Mutation_p.E152G	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	1851					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						GACCCAAAATTCATTGCTGTC	0.517000													155	728					0	0	1	0	0
ALDH5A1	7915	broad.mit.edu	37	6	24515421	24515421	+	Silent	SNP	A	A	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:24515421A>G	ENST00000357578.3	+	5	898	c.753A>G	c.(751-753)tcA>tcG	p.S251S	ALDH5A1_ENST00000546278.1_Silent_p.S163S|ALDH5A1_ENST00000348925.2_Silent_p.S264S|ALDH5A1_ENST00000491546.1_Silent_p.S223S	NM_001080.3	NP_001071.1	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5 family, member A1	251					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|skin(2)|urinary_tract(1)	20					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	GGATTCCTTCAGGTGTATACA	0.378000													102	366					0	0	1	0	0
KIR3DX1	0	broad.mit.edu	37	19	55045157	55045157	+	Missense_Mutation	SNP	A	A	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:55045157A>G	ENST00000335056.3	+	3	315	c.277A>G	c.(277-279)Aga>Gga	p.R93G																	endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		AGGGACCTACAGATGTGTTGG	0.527000													39	121					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124380681	124380681	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr10:124380681G>A	ENST00000338354.3	+	41	5112	c.5006G>A	c.(5005-5007)tGg>tAg	p.W1669*	DMBT1_ENST00000344338.3_Nonsense_Mutation_p.W1659*|DMBT1_ENST00000368956.2_Nonsense_Mutation_p.W1041*|DMBT1_ENST00000330163.4_Nonsense_Mutation_p.W1041*|DMBT1_ENST00000368955.3_Nonsense_Mutation_p.W1659*|DMBT1_ENST00000368909.3_Nonsense_Mutation_p.W1669*|DMBT1_ENST00000359586.6_Intron			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1669	SRCR 13.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GATGACAGCTGGGACACCAAT	0.612000													34	1502					0	0	1	0	0
CXCR1	3577	broad.mit.edu	37	2	219029669	219029669	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:219029669G>A	ENST00000295683.2	-	2	386	c.266C>T	c.(265-267)gCc>gTc	p.A89V		NM_000634.2	NP_000625.1	P25024	CXCR1_HUMAN	chemokine (C-X-C motif) receptor 1	89					dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(3)	13						CAAGGTCAGGGCAAAGAGTAG	0.557000													13	429					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74622597	74622597	+	Missense_Mutation	SNP	C	C	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr15:74622597C>A	ENST00000321288.5	+	14	1967	c.1967C>A	c.(1966-1968)gCc>gAc	p.A656D	CCDC33_ENST00000398814.3_Missense_Mutation_p.A453D|CCDC33_ENST00000268082.4_Missense_Mutation_p.A46D|CCDC33_ENST00000558821.1_Missense_Mutation_p.A46D			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	656							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CGGAGACAGGCCAGCATCCTG	0.622000													11	74					1.58986e-06	1.67994e-06	1	1	0
HTR5A	3361	broad.mit.edu	37	7	154876006	154876006	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:154876006G>A	ENST00000287907.2	+	2	1459	c.883G>A	c.(883-885)Gtg>Atg	p.V295M	HTR5A_ENST00000486819.1_3'UTR	NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	295						integral to plasma membrane	serotonin receptor activity	p.V295M(2)		NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		TGGCGTGTTCGTGCTCTGCTG	0.622000													28	625					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51175457	51175457	+	Missense_Mutation	SNP	C	C	T	rs149603480		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr16:51175457C>T	ENST00000440970.1	-	2	816	c.385G>A	c.(385-387)Gtc>Atc	p.V129I	SALL1_ENST00000251020.4_Missense_Mutation_p.V226I|SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	226					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.V226I(1)		NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			AGGGCTGGGACGGCCAGCTTG	0.592000													225	243					0	0	1	0	0
ARHGEF37	389337	broad.mit.edu	37	5	149011717	149011717	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:149011717G>A	ENST00000333677.6	+	13	2154	c.1991G>A	c.(1990-1992)cGg>cAg	p.R664Q		NM_001001669.2	NP_001001669.2	A1IGU5	ARH37_HUMAN	Rho guanine nucleotide exchange factor (GEF) 37	664	SH3 2.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(5)|lung(6)|ovary(1)|prostate(2)|stomach(3)	17						GCCAGGGCTCGGAGCCCAGTT	0.592000													11	264					0	0	1	0	0
SF3B14	0	broad.mit.edu	37	2	24299094	24299094	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:24299094C>T	ENST00000233468.4	-	1	219	c.6G>A	c.(4-6)gcG>gcA	p.A2A		NM_016047.3	NP_057131.1	Q9Y3B4	PM14_HUMAN		2					nuclear mRNA splicing, via spliceosome	nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			NS(1)|kidney(1)|large_intestine(1)|lung(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCGCTTGCATCGCCATCTTGG	0.567000													173	337					0	0	1	0	0
SOCS4	122809	broad.mit.edu	37	14	55510690	55510690	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr14:55510690C>T	ENST00000395472.2	+	2	1263	c.931C>T	c.(931-933)Cga>Tga	p.R311*	SOCS4_ENST00000555846.1_Nonsense_Mutation_p.R311*|SOCS4_ENST00000339298.2_Nonsense_Mutation_p.R311*	NM_080867.2|NM_199421.1	NP_543143.1|NP_955453.1	Q8WXH5	SOCS4_HUMAN	suppressor of cytokine signaling 4	311	SH2.				intracellular signal transduction|negative regulation of signal transduction|regulation of growth			p.R311*(1)		central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	14						CTTTTTACTTCGAGACTCAGC	0.418000													8	537					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184298566	184298566	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:184298566G>A	ENST00000330394.2	+	13	2890	c.2438G>A	c.(2437-2439)cGg>cAg	p.R813Q	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	813	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			ATAGCCTATCGGAAGTTCACT	0.602000													117	116					0	0	1	0	0
ST6GALNAC3	256435	broad.mit.edu	37	1	76779655	76779655	+	Missense_Mutation	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:76779655T>C	ENST00000328299.3	+	2	332	c.184T>C	c.(184-186)Tat>Cat	p.Y62H	ST6GALNAC3_ENST00000464140.1_3'UTR	NM_152996.2	NP_694541.2	Q8NDV1	SIA7C_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	62					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|ovary(3)|prostate(1)|skin(2)	36						TCGAACTCACTATGGATACAT	0.443000													8	213					0	0	1	0	0
CPNE3	8895	broad.mit.edu	37	8	87549866	87549866	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr8:87549866C>T	ENST00000521271.1	+	7	697	c.535C>T	c.(535-537)Cgg>Tgg	p.R179W	CPNE3_ENST00000198765.4_Missense_Mutation_p.R179W	NM_003909.3	NP_003900.1	O75131	CPNE3_HUMAN	copine III	179	C2 2.				lipid metabolic process|vesicle-mediated transport	cytosol	calcium-dependent phospholipid binding|protein serine/threonine kinase activity|transporter activity	p.R179W(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	23						AATGGTTCATCGGACAGAGGT	0.323000													16	401					0	0	1	0	0
KIAA0907	22889	broad.mit.edu	37	1	155887393	155887393	+	Missense_Mutation	SNP	T	T	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:155887393T>G	ENST00000368320.3	-	11	1362	c.1337A>C	c.(1336-1338)cAg>cCg	p.Q446P	KIAA0907_ENST00000368321.3_Missense_Mutation_p.Q446P			Q7Z7F0	K0907_HUMAN	KIAA0907	446	Pro-rich.									breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|urinary_tract(1)	21	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			gggctggggctggggctgggg	0.567000													15	101					0	0	1	0	0
KSR1	8844	broad.mit.edu	37	17	25783779	25783779	+	Missense_Mutation	SNP	C	C	A	rs143611966	by1000genomes	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr17:25783779C>A	ENST00000319524.6	+	1	110	c.110C>A	c.(109-111)gCg>gAg	p.A37E	KSR1_ENST00000509603.2_Missense_Mutation_p.A37E			Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	35					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.A37E(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		GCCAGCCGGGCGCTGCAGCAG	0.741000													6	80					0.00448238	0.00454328	1	1	0
OR10A6	390093	broad.mit.edu	37	11	7950055	7950055	+	Missense_Mutation	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:7950055T>C	ENST00000309838.2	-	1	154	c.155A>G	c.(154-156)gAc>gGc	p.D52G		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	52					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GAGGCTCTGGTCTAGGGAGAC	0.478000													11	410					0	0	1	0	0
IAPP	3375	broad.mit.edu	37	12	21531268	21531268	+	Missense_Mutation	SNP	C	C	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:21531268C>G	ENST00000240652.3	+	3	314	c.178C>G	c.(178-180)Ctc>Gtc	p.L60V	SLCO1A2_ENST00000473830.1_Intron|SLCO1A2_ENST00000307378.6_Intron|IAPP_ENST00000539393.1_Missense_Mutation_p.L60V|SLCO1A2_ENST00000537524.1_Intron|IAPP_ENST00000542023.1_3'UTR	NM_000415.2	NP_000406.1	P10997	IAPP_HUMAN	islet amyloid polypeptide	60					apoptosis|cell-cell signaling|endocrine pancreas development|signal transduction	extracellular region|soluble fraction	hormone activity			lung(3)	3					Perindopril(DB00790)	TGGTGCCATTCTCTCATCTAC	0.453000													238	258					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	161924	161924	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:161924G>A	ENST00000283426.6	+	10	1496	c.1446G>A	c.(1444-1446)ctG>ctA	p.L482L		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	482					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GACTACAGCTGGCGAAGGAGA	0.582000													46	199					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45855046	45855046	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr21:45855046G>A	ENST00000397928.1	+	28	4452	c.4007G>A	c.(4006-4008)cGc>cAc	p.R1336H	TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Missense_Mutation_p.R1282H|TRPM2_ENST00000300482.5_Missense_Mutation_p.R1336H|TRPM2_ENST00000397932.2_Missense_Mutation_p.R1386H	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1336						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity	p.R1336H(1)		breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CTGCGTGGGCGCGGGAGCCTC	0.667000													91	276					0	0	1	0	0
ZBED1	9189	broad.mit.edu	37	X	2408374	2408374	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chrX:2408374G>A	ENST00000381223.4	-	2	590	c.387C>T	c.(385-387)gcC>gcT	p.A129A	ZBED1_ENST00000381218.3_Silent_p.A129A|DHRSX_ENST00000334651.5_Intron|ZBED1_ENST00000381222.2_Silent_p.A129A	NM_001171135.1|NM_001171136.1|NM_004729.3	NP_001164606.1|NP_001164607.1|NP_004720.1	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	129						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity			endometrium(8)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	25		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGCCCAGCACGGCGGCCGTCA	0.687000													5	172					0	0	1	0	0
AGFG2	3268	broad.mit.edu	37	7	100160565	100160565	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:100160565G>A	ENST00000300176.4	+	9	1289	c.1167G>A	c.(1165-1167)gcG>gcA	p.A389A	AGFG2_ENST00000474713.1_Intron|AGFG2_ENST00000262935.4_3'UTR	NM_006076.4	NP_006067.3	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	389	Pro-rich.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						ATGGCTTGGCGCCAGGTAAGC	0.602000													9	176					0	0	1	0	0
TRAPPC11	60684	broad.mit.edu	37	4	184598641	184598641	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:184598641C>T	ENST00000334690.6	+	8	967	c.765C>T	c.(763-765)caC>caT	p.H255H	TRAPPC11_ENST00000357207.4_Silent_p.H255H|TRAPPC11_ENST00000511409.1_3'UTR	NM_021942.5	NP_068761.4	Q7Z392	CD041_HUMAN	trafficking protein particle complex 11	255																	ATCTTGTACACGAATTGAGAG	0.323000													19	646					0	0	1	0	0
PCDHB7	0	broad.mit.edu	37	5	140554443	140554443	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:140554443C>T	ENST00000231137.3	+	1	2201	c.2027C>T	c.(2026-2028)gCg>gTg	p.A676V		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		676					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCCGGAGGCGGCCCCGGAC	0.692000													31	410					0	0	1	0	0
TCP10	6953	broad.mit.edu	37	6	167796338	167796338	+	Silent	SNP	G	G	A	rs146766441	by1000genomes	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:167796338G>A	ENST00000366827.2	-	2	235	c.24C>T	c.(22-24)gcC>gcT	p.A8A	TCP10_ENST00000397829.4_Silent_p.A8A|TCP10_ENST00000476779.2_Silent_p.A8A			Q12799	TCP10_HUMAN	t-complex 10	35						cytosol				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(6)	18		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		TGGGGACCTCGGCTGCTGCAG	0.667000													28	72					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75108727	75108727	+	Missense_Mutation	SNP	C	C	T	rs148337951	byFrequency	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:75108727C>T	ENST00000326665.5	-	4	517	c.299G>A	c.(298-300)cGa>cAa	p.R100Q		NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	100										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CCTCTGGATTCGCTCCTTCCT	0.323000													7	297					0	0	1	0	0
TPTE2P6	0	broad.mit.edu	37	13	25171679	25171679	+	RNA	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr13:25171679T>C	ENST00000453498.1	+	0	1575																											CTTCCCCTTCTGGGAAAGAAT	0.378000													68	60					0	0	1	0	0
METAP2	10988	broad.mit.edu	37	12	95907493	95907493	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:95907493G>A	ENST00000323666.5	+	11	1479	c.1250G>A	c.(1249-1251)cGc>cAc	p.R417H	METAP2_ENST00000546753.1_Missense_Mutation_p.R394H|METAP2_ENST00000261220.9_Missense_Mutation_p.R394H|METAP2_ENST00000551840.1_Missense_Mutation_p.R416H|METAP2_ENST00000550777.1_Missense_Mutation_p.R381H	NM_006838.3	NP_006829.1	P50579	AMPM2_HUMAN	methionyl aminopeptidase 2	417					N-terminal protein amino acid modification|peptidyl-methionine modification|protein processing|proteolysis	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|large_intestine(2)|lung(7)|prostate(1)	13					L-Methionine(DB00134)	GCCTTCTGCCGCAGATGGCTG	0.408000													20	484					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915439	119915439	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:119915439G>A	ENST00000331113.4	+	1	1718	c.753G>A	c.(751-753)gcG>gcA	p.A251A		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	251					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					TGGCTGCAGCGCCTAGTCGTT	0.532000													191	202					0	0	1	0	0
FAM110B	90362	broad.mit.edu	37	8	59059480	59059480	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr8:59059480G>A	ENST00000361488.3	+	5	1571	c.691G>A	c.(691-693)Gca>Aca	p.A231T	FAM110B_ENST00000520369.1_Intron	NM_147189.2	NP_671722.1	Q8TC76	F110B_HUMAN	family with sequence similarity 110, member B	231						microtubule organizing center|mitochondrion|nucleus				breast(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)	26		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				GCCCAAAATCGCAGCCATCGC	0.627000													20	417					0	0	1	0	0
NFIB	4781	broad.mit.edu	37	9	14120485	14120485	+	Missense_Mutation	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:14120485T>C	ENST00000380959.3	-	8	1672	c.1199A>G	c.(1198-1200)aAg>aGg	p.K400R	NFIB_ENST00000543693.1_Missense_Mutation_p.K148R|NFIB_ENST00000380953.1_Missense_Mutation_p.K400R|NFIB_ENST00000397579.2_Missense_Mutation_p.K400R|NFIB_ENST00000380924.1_Missense_Mutation_p.K148R|NFIB_ENST00000380934.4_Missense_Mutation_p.K426R|NFIB_ENST00000397581.2_Missense_Mutation_p.K400R|NFIB_ENST00000397575.3_Missense_Mutation_p.K400R	NM_005596.3	NP_005587.2	O00712	NFIB_HUMAN	nuclear factor I/B	400					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		TACATAGTTCTTCAGAGTATC	0.443000			T	"""MYB, HGMA2"""	"""adenoid cystic carcinoma, lipoma"""								12	557					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81172080	81172080	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr15:81172080G>A	ENST00000394685.3	+	5	684	c.265G>A	c.(265-267)Gac>Aac	p.D89N	KIAA1199_ENST00000356249.5_Missense_Mutation_p.D89N|KIAA1199_ENST00000220244.3_Missense_Mutation_p.D89N			Q8WUJ3	K1199_HUMAN	KIAA1199	89	G8.									breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						TAAAGACCACGACGAGCCGAT	0.517000													89	292					0	0	1	0	0
IDO2	169355	broad.mit.edu	37	8	39872943	39872943	+	Missense_Mutation	SNP	C	C	G	rs143841632	by1000genomes	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr8:39872943C>G	ENST00000502986.2	+	11	1327	c.1085C>G	c.(1084-1086)aCc>aGc	p.T362S	IDO2_ENST00000389060.4_Missense_Mutation_p.T349S|IDO2_ENST00000343295.4_3'UTR	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	349					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						TATCACATCACCATGGTCACC	0.547000													5	247					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92459385	92459385	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr15:92459385G>A	ENST00000318445.6	+	2	557	c.343G>A	c.(343-345)Gtc>Atc	p.V115I	SLCO3A1_ENST00000424469.2_Missense_Mutation_p.V115I	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	115					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			CGGCGGCATCGTCATGGCGCT	0.706000													4	70					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11291104	11291104	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:11291104C>T	ENST00000361445.4	-	18	2733	c.2657G>A	c.(2656-2658)cGt>cAt	p.R886H		NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	886					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						CCCTAACACACGGATGGCCTG	0.478000													87	213					0	0	1	0	0
ANKRD20A8P	0	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:95522786T>C	ENST00000432432.2	-	0	241					NR_040113.1													p.K44K(1)									CGGCGTCGCCTTTGACAGCTG	0.687000													6	245					0	0	1	0	0
AC009499.1	0	broad.mit.edu	37	2	33952796	33952796	+	RNA	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:33952796C>T	ENST00000366209.2	+	0	68				MYADML_ENST00000474610.1_RNA																							CAAGGGGAAGCGGGCCTGGGA	0.592000													51	74					0	0	1	0	0
ARID3B	10620	broad.mit.edu	37	15	74883672	74883672	+	Silent	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr15:74883672T>C	ENST00000346246.5	+	6	1293	c.1062T>C	c.(1060-1062)ctT>ctC	p.L354L		NM_006465.2	NP_006456.1	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B (BRIGHT-like)	354	Interaction with RB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.L354L(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(2)	14						CCCCTGCCCTTCTCTCCCCAC	0.647000													6	499					0	0	1	0	0
LPPR5	0	broad.mit.edu	37	1	99418649	99418649	+	Missense_Mutation	SNP	C	C	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:99418649C>G	ENST00000370188.3	-	3	958	c.598G>C	c.(598-600)Gtc>Ctc	p.V200L	LPPR5_ENST00000263177.4_Missense_Mutation_p.V200L	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN		200						integral to membrane	hydrolase activity										GCTGCATAGACACTGAGAGCT	0.388000													9	213					0	0	1	0	0
SLC25A36	55186	broad.mit.edu	37	3	140689817	140689817	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:140689817G>A	ENST00000446041.2	+	5	659	c.434G>A	c.(433-435)cGg>cAg	p.R145Q	SLC25A36_ENST00000324194.6_Missense_Mutation_p.R145Q|SLC25A36_ENST00000453248.2_Missense_Mutation_p.R119Q	NM_001104647.1|NM_018155.2	NP_001098117.1|NP_060625.2	Q96CQ1	S2536_HUMAN	solute carrier family 25 (pyrimidine nucleotide carrier ), member 36	145					response to estradiol stimulus|transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			endometrium(2)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	6						ATAAAGACTCGGTTACAGCTT	0.308000													27	248					0	0	1	0	0
ZCCHC4	29063	broad.mit.edu	37	4	25366651	25366651	+	Silent	SNP	C	C	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:25366651C>A	ENST00000302874.4	+	12	1293	c.1269C>A	c.(1267-1269)atC>atA	p.I423I		NM_024936.2	NP_079212.2	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	423							methyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)	9		Breast(46;0.0503)				CAGCCTGGATCCACTGTAGCA	0.368000													16	422					3.32936e-07	3.52799e-07	1	1	0
ZNF563	147837	broad.mit.edu	37	19	12429722	12429722	+	Missense_Mutation	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:12429722T>C	ENST00000293725.5	-	4	1322	c.1117A>G	c.(1117-1119)Acg>Gcg	p.T373A		NM_145276.2	NP_660319.1	Q8TA94	ZN563_HUMAN	zinc finger protein 563	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TGAGATAACGTTTTCCCACAC	0.413000													6	658					0	0	1	0	0
LPPR4	0	broad.mit.edu	37	1	99771763	99771763	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:99771763C>T	ENST00000370185.3	+	7	1986	c.1489C>T	c.(1489-1491)Cct>Tct	p.P497S	LPPR4_ENST00000457765.1_Missense_Mutation_p.P439S|LPPR4_ENST00000370184.1_Missense_Mutation_p.P339S	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		497							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CCACCATGGTCCTGGCAATCA	0.562000													13	624					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124740169	124740169	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:124740169G>A	ENST00000397801.1	+	5	1067	c.875G>A	c.(874-876)cGc>cAc	p.R292H	ROBO3_ENST00000538940.1_Missense_Mutation_p.R270H	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	292	Ig-like C2-type 3.				axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CTACGCTGGCGCAAGGAGGAT	0.577000													35	94					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80408515	80408515	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:80408515C>T	ENST00000265080.4	+	14	1992	c.1925C>T	c.(1924-1926)gCc>gTc	p.A642V		NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	642	N-terminal Ras-GEF.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		ATCCGTTATGCCAGCGTGGAG	0.483000													6	987					0	0	1	0	0
DMWD	1762	broad.mit.edu	37	19	46289829	46289829	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:46289829G>A	ENST00000270223.6	-	3	970	c.925C>T	c.(925-927)Cgc>Tgc	p.R309C	DMWD_ENST00000377735.3_Missense_Mutation_p.R309C	NM_004943.1	NP_004934.1	Q09019	DMWD_HUMAN	dystrophia myotonica, WD repeat containing	309					meiosis					central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		TGGAAGACGCGCAGGCAGCCA	0.667000													6	161					0	0	1	0	0
KLKB1	3818	broad.mit.edu	37	4	187172778	187172778	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:187172778C>T	ENST00000264690.6	+	9	1193	c.1006C>T	c.(1006-1008)Ctc>Ttc	p.L336F	KLKB1_ENST00000513864.1_Missense_Mutation_p.L336F	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	336	Apple 4.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		TTATTCTTTACTCCCAGAAGA	0.368000													41	374					0	0	1	0	0
LOXL3	84695	broad.mit.edu	37	2	74763164	74763164	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:74763164C>T	ENST00000264094.3	-	7	1278	c.1207G>A	c.(1207-1209)Ggg>Agg	p.G403R	LOXL3_ENST00000409249.1_Intron|LOXL3_ENST00000409549.1_Missense_Mutation_p.G403R|LOXL3_ENST00000393937.2_Missense_Mutation_p.G258R|LOXL3_ENST00000409986.1_Missense_Mutation_p.G258R	NM_032603.2	NP_115992.1	P58215	LOXL3_HUMAN	lysyl oxidase-like 3	403	SRCR 3.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity			endometrium(7)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	30						CACCGGACCCCGGCATCCTGG	0.562000													11	381					0	0	1	0	0
TGM4	7047	broad.mit.edu	37	3	44932185	44932185	+	Nonsense_Mutation	SNP	G	G	T	rs56944783		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:44932185G>T	ENST00000296125.4	+	4	459	c.391G>T	c.(391-393)Gaa>Taa	p.E131*		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	131					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	TAAGTCTGAAGAAAACATCCT	0.493000													5	248					0.000602214	0.000613732	1	1	0
PRG4	10216	broad.mit.edu	37	1	186276229	186276229	+	Missense_Mutation	SNP	A	A	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:186276229A>G	ENST00000445192.2	+	7	1423	c.1378A>G	c.(1378-1380)Aca>Gca	p.T460A	PRG4_ENST00000367485.4_Missense_Mutation_p.T367A|PRG4_ENST00000367483.4_Missense_Mutation_p.T419A|PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367486.3_Missense_Mutation_p.T417A	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	460	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity	p.T460A(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CAAGGAGCCTACACCCACCAC	0.657000													12	488					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113166756	113166756	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:113166756T>A	ENST00000401783.2	-	39	9853	c.9517A>T	c.(9517-9519)Aga>Tga	p.R3173*	SVEP1_ENST00000297826.5_Nonsense_Mutation_p.R1099*|SVEP1_ENST00000374469.1_Nonsense_Mutation_p.R3150*	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	3173	Sushi 29.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CAGGAGATTCTCTCAGGGAAC	0.423000													8	1212					0	0	1	0	0
PSMG3	84262	broad.mit.edu	37	7	1607453	1607453	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:1607453C>T	ENST00000288607.2	-	2	903	c.250G>A	c.(250-252)Gcg>Acg	p.A84T	PSMG3_ENST00000252329.3_Missense_Mutation_p.A84T|PSMG3_ENST00000404674.3_Missense_Mutation_p.A84T	NM_032302.3	NP_115678.1	Q9BT73	PSMG3_HUMAN	proteasome (prosome, macropain) assembly chaperone 3	84										lung(2)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.63e-15)		GACACAAACGCTACCAGGTTC	0.498000													44	380					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57597244	57597244	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:57597244C>T	ENST00000243077.3	+	70	11357	c.10891C>T	c.(10891-10893)Cgc>Tgc	p.R3631C		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3631	LDL-receptor class A 28.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCTGCGCTGGCGCTGTGACGC	0.687000													4	59					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57588845	57588845	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:57588845G>A	ENST00000243077.3	+	51	8735	c.8269G>A	c.(8269-8271)Gat>Aat	p.D2757N		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	2757	LDL-receptor class A 16.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGACGGCAGCGATGACTGTGG	0.612000													19	626					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178552067	178552067	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:178552067G>A	ENST00000251582.7	-	19	2966	c.2865C>T	c.(2863-2865)caC>caT	p.H955H		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	955	TSP type-1 3.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		AGTGCTTGGCGTGCACGGAGC	0.692000													8	708					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109691963	109691963	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:109691963C>T	ENST00000277225.5	+	3	6059	c.5770C>T	c.(5770-5772)Cgt>Tgt	p.R1924C	ZNF462_ENST00000457913.1_Missense_Mutation_p.R1924C|ZNF462_ENST00000441147.2_Missense_Mutation_p.R769C|ZNF462_ENST00000497489.1_3'UTR			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1924					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						GCGTGCCAAACGTCAGGAGAG	0.453000													12	338					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151130916	151130916	+	Missense_Mutation	SNP	C	C	T	rs75100154		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chrX:151130916C>T	ENST00000370325.1	-	4	595	c.542G>A	c.(541-543)gGc>gAc	p.G181D	GABRE_ENST00000370328.3_Missense_Mutation_p.G181D|GABRE_ENST00000393914.3_Missense_Mutation_p.A16T			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	181					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					CAACACCTTGCCATCCTTGTA	0.478000													5	142					0	0	1	0	0
PDPN	10630	broad.mit.edu	37	1	13910573	13910573	+	Silent	SNP	G	G	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:13910573G>T	ENST00000294489.6	+	1	614	c.273G>T	c.(271-273)tcG>tcT	p.S91S	PDPN_ENST00000376057.4_Silent_p.S91S			Q86YL7	PDPN_HUMAN	podoplanin	15					cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane		p.S91S(1)		endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	16	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		GAAGCGCGTCGCTCTGGGTCC	0.612000													8	133					0.0381472	0.0382498	1	1	0
KCNH5	27133	broad.mit.edu	37	14	63246448	63246448	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr14:63246448G>A	ENST00000322893.7	-	10	2285	c.2017C>T	c.(2017-2019)Cgg>Tgg	p.R673W	KCNH5_ENST00000394968.1_Missense_Mutation_p.R615W|KCNH5_ENST00000420622.2_Intron	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	673					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity	p.R673W(2)		NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GAACATACCCGTTTCCTCAGA	0.398000													8	622					0	0	1	0	0
EDA2R	60401	broad.mit.edu	37	X	65824331	65824331	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chrX:65824331C>T	ENST00000374719.3	-	4	340	c.284G>A	c.(283-285)cGc>cAc	p.R95H	EDA2R_ENST00000450752.1_Missense_Mutation_p.R95H|EDA2R_ENST00000456230.2_Missense_Mutation_p.R95H|EDA2R_ENST00000253392.5_Missense_Mutation_p.R95H|EDA2R_ENST00000396050.1_Missense_Mutation_p.R95H|EDA2R_ENST00000451436.2_Intron	NM_021783.3	NP_068555.1	Q9HAV5	TNR27_HUMAN	ectodysplasin A2 receptor	95					cell differentiation|embryo development|epidermis development|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	13						GCCTCCAATGCGTGTCTTTCG	0.522000													172	17					0	0	1	0	0
IRF8	3394	broad.mit.edu	37	16	85952250	85952250	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr16:85952250G>A	ENST00000268638.5	+	7	1251	c.829G>A	c.(829-831)Ggg>Agg	p.G277R	IRF8_ENST00000562492.1_Missense_Mutation_p.G73R	NM_002163.2	NP_002154.1	Q02556	IRF8_HUMAN	interferon regulatory factor 8	277					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	24		Prostate(104;0.0771)				CCTGGAGCGCGGGGTGCTGCT	0.721000													9	89					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101606007	101606007	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr15:101606007G>A	ENST00000284395.5	+	33	5756	c.5356G>A	c.(5356-5358)Gtg>Atg	p.V1786M	LRRK1_ENST00000532145.1_3'UTR|LRRK1_ENST00000388948.3_Missense_Mutation_p.V1789M|RP11-505E24.2_ENST00000559857.1_RNA			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1789					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.V1789M(1)|p.V1801M(1)		breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CATGTTTCCCGTGCGGCCCTT	0.632000													4	115					0	0	1	0	0
MLANA	2315	broad.mit.edu	37	9	5906999	5906999	+	Splice_Site	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:5906999G>A	ENST00000381477.3	+	4	448		c.e4+1		KIAA2026_ENST00000443149.2_Intron|MLANA_ENST00000381476.1_Splice_Site|MLANA_ENST00000381471.1_Splice_Site|MLANA_ENST00000490518.1_3'UTR	NM_005511.1	NP_005502.1	Q16655	MAR1_HUMAN	melan-A							endoplasmic reticulum membrane|integral to plasma membrane|melanosome|trans-Golgi network	protein binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(1)	8		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(1;1.15e-06)|Lung(218;0.103)		TGAACCTGTGGTAGGTTAAGA	0.378000													5	321					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767077	77767077	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr8:77767077C>T	ENST00000521891.2	+	10	8368	c.7920C>T	c.(7918-7920)cgC>cgT	p.R2640R	ZFHX4_ENST00000518282.1_Silent_p.R2614R|ZFHX4_ENST00000455469.2_Silent_p.R2595R|ZFHX4_ENST00000050961.6_Silent_p.R2595R	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2595						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATATTGCCCGCGAAGTCGGGC	0.517000										HNSCC(33;0.089)			6	254					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628278	29628278	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr20:29628278G>A	ENST00000278882.3	+	6	660	c.280G>A	c.(280-282)Gca>Aca	p.A94T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A99T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A94T																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGCAATGAAGCAGGGGACAT	0.373000													16	501					0	0	1	0	0
SERPINI1	5274	broad.mit.edu	37	3	167525063	167525063	+	Missense_Mutation	SNP	G	G	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:167525063G>T	ENST00000295777.5	+	6	1344	c.913G>T	c.(913-915)Gat>Tat	p.D305Y	SERPINI1_ENST00000446050.2_Missense_Mutation_p.D305Y|SERPINI1_ENST00000488374.1_3'UTR	NM_005025.4	NP_005016.1	Q99574	NEUS_HUMAN	serpin peptidase inhibitor, clade I (neuroserpin), member 1	305					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(7)|skin(2)	20						TGATTTAAAAGATGTTTTGAA	0.323000													16	356					1.87028e-06	1.97066e-06	1	1	0
FAM129A	116496	broad.mit.edu	37	1	184772798	184772798	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:184772798C>T	ENST00000367511.3	-	12	1668	c.1475G>A	c.(1474-1476)cGa>cAa	p.R492Q	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	492					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane		p.R492Q(1)		autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						TATCTTCTTTCGGATGGTGCT	0.388000													45	448					0	0	1	0	0
CYP2C18	1562	broad.mit.edu	37	10	96466679	96466679	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr10:96466679C>T	ENST00000285979.6	+	5	980	c.781C>T	c.(781-783)Cgg>Tgg	p.R261W	CYP2C19_ENST00000464755.1_3'UTR|CYP2C18_ENST00000339022.5_Intron	NM_000772.2	NP_000763.1			cytochrome P450, family 2, subfamily C, polypeptide 18											NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	26		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		GAACAGTGCTCGGGACTTTAT	0.328000													5	373					0	0	1	0	0
LILRA2	0	broad.mit.edu	37	19	55086976	55086976	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:55086976C>T	ENST00000251377.3	+	6	1042	c.909C>T	c.(907-909)tcC>tcT	p.S303S	LILRA2_ENST00000391737.1_Silent_p.S291S|LILRB1_ENST00000448689.1_Intron|LILRA2_ENST00000391738.3_Silent_p.S303S|LILRB1_ENST00000418536.2_Intron|LILRA2_ENST00000251376.3_Silent_p.S303S|LILRB1_ENST00000396321.2_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2									p.S303S(1)		breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		ACCTCTCCTCCGAGTGGTCGG	0.672000													7	305					0	0	1	0	0
TP73	7161	broad.mit.edu	37	1	3638720	3638720	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:3638720G>A	ENST00000378295.4	+	5	720	c.565G>A	c.(565-567)Gac>Aac	p.D189N	TP73_ENST00000378280.1_Missense_Mutation_p.D140N|TP73_ENST00000378285.1_Missense_Mutation_p.D140N|TP73_ENST00000357733.3_Missense_Mutation_p.D189N|TP73_ENST00000604074.1_Missense_Mutation_p.D189N|TP73_ENST00000346387.4_Missense_Mutation_p.D189N|TP73_ENST00000378290.4_Missense_Mutation_p.D118N|TP73_ENST00000354437.4_Missense_Mutation_p.D189N|TP73_ENST00000603362.1_Missense_Mutation_p.D189N|TP73_ENST00000378288.4_Missense_Mutation_p.D140N|TP73_ENST00000604479.1_Missense_Mutation_p.D189N	NM_001204185.1|NM_005427.3	NP_001191114.1|NP_005418.1	O15350	P73_HUMAN	tumor protein p73	189	DNA-binding (Potential).				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|lung(8)|ovary(1)|prostate(1)	20	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		GCACGTGACCGACGTCGTGAA	0.647000													5	155					0	0	1	0	0
JAG1	182	broad.mit.edu	37	20	10629323	10629323	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr20:10629323G>A	ENST00000254958.5	-	12	1958	c.1443C>T	c.(1441-1443)ggC>ggT	p.G481G	JAG1_ENST00000423891.2_Silent_p.G322G	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	481	EGF-like 7; calcium-binding (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						CACAGTGATCGCCTGCATAGC	0.463000									Alagille Syndrome				36	330					0	0	1	0	0
C20orf166	128826	broad.mit.edu	37	20	61162268	61162268	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr20:61162268G>A	ENST00000370527.3	+	3	860	c.81G>A	c.(79-81)gtG>gtA	p.V27V	C20orf166_ENST00000370524.2_Intron|C20orf166_ENST00000370523.1_Intron	NM_178463.3	NP_848558.1	Q9H1L0	CT166_HUMAN	chromosome 20 open reading frame 166	27			V -> A (in dbSNP:rs6062251).							endometrium(1)|kidney(1)|lung(2)	4	Breast(26;1.04e-08)		BRCA - Breast invasive adenocarcinoma(19;7.17e-06)			CCCAGCAGGTGGCGCGGGGAG	0.677000													15	90					0	0	1	0	0
SCG2	7857	broad.mit.edu	37	2	224463590	224463590	+	Missense_Mutation	SNP	C	C	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:224463590C>A	ENST00000305409.2	-	2	643	c.411G>T	c.(409-411)ttG>ttT	p.L137F		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	137					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TTTCTGAATTCAAGGCATAGG	0.418000													283	437					2.16399e-160	2.38102e-160	1	1	0
SBNO1	55206	broad.mit.edu	37	12	123780522	123780522	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:123780522G>A	ENST00000420886.2	-	31	4114	c.4115C>T	c.(4114-4116)gCg>gTg	p.A1372V	SBNO1_ENST00000267176.4_Missense_Mutation_p.A1371V|SBNO1_ENST00000602750.1_Missense_Mutation_p.A1371V|SBNO1_ENST00000602398.1_Missense_Mutation_p.A1372V	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	1372							ATP binding|DNA binding|hydrolase activity	p.A1371V(2)		NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CTGTTGGACCGCAAGCTGTTG	0.433000													7	964					0	0	1	0	0
SNPH	9751	broad.mit.edu	37	20	1277814	1277814	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr20:1277814C>T	ENST00000381867.1	+	5	850	c.208C>T	c.(208-210)Cgg>Tgg	p.R70W	SNPH_ENST00000381873.3_Missense_Mutation_p.R26W			O15079	SNPH_HUMAN	syntaphilin	26					synaptic vesicle docking involved in exocytosis	cell junction|integral to membrane|synapse|synaptosome	syntaxin-1 binding			endometrium(2)|large_intestine(4)|lung(10)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						TGTGAGCGTGCGGGATGCCTA	0.637000													28	160					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42052633	42052633	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr15:42052633G>A	ENST00000219905.7	+	20	7485	c.7304G>A	c.(7303-7305)cGg>cAg	p.R2435Q	MGA_ENST00000570161.1_Missense_Mutation_p.R2435Q|MGA_ENST00000545763.1_Missense_Mutation_p.R2226Q|MGA_ENST00000389936.4_Missense_Mutation_p.R2396Q|MGA_ENST00000566586.1_Missense_Mutation_p.R2226Q	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	2396	Helix-loop-helix motif.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity	p.R2484Q(4)		NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GAGCGGCGGCGGCGTGGTGAA	0.438000													18	318					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101194865	101194865	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:101194865C>T	ENST00000294728.2	+	5	1232	c.1131C>T	c.(1129-1131)aaC>aaT	p.N377N	VCAM1_ENST00000370119.4_Silent_p.N315N|VCAM1_ENST00000370115.1_Intron|VCAM1_ENST00000347652.2_Intron	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	377	Ig-like C2-type 4.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	GTTTTGAGAACGAACACTCTT	0.493000													41	447					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57484420	57484420	+	Missense_Mutation	SNP	C	C	T	rs11554273		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr20:57484420C>T	ENST00000371100.4	+	8	3082	c.2530C>T	c.(2530-2532)Cgt>Tgt	p.R844C	GNAS_ENST00000371085.3_Missense_Mutation_p.R201C|GNAS_ENST00000354359.7_Missense_Mutation_p.R202C|GNAS_ENST00000371075.3_3'UTR|GNAS_ENST00000371095.3_Missense_Mutation_p.R187C|GNAS_ENST00000265620.7_Missense_Mutation_p.R186C|GNAS_ENST00000306090.10_Missense_Mutation_p.R187C|GNAS_ENST00000313949.7_3'UTR|GNAS_ENST00000371102.4_Missense_Mutation_p.R830C|GNAS_ENST00000464624.2_3'UTR	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	201					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity	p.R201C(228)|p.R844C(9)|p.R201S(5)		adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GCTTCGCTGCCGTGTCCTGAC	0.428000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			413	15					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47373562	47373562	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr18:47373562C>T	ENST00000285039.7	-	33	4712	c.4413G>A	c.(4411-4413)gaG>gaA	p.E1471E	SCARNA17_ENST00000589499.1_RNA|MYO5B_ENST00000324581.6_Silent_p.E586E|MYO5B_ENST00000592688.1_Silent_p.E41E	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1471					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CTTTGTGGTACTCCAGCATGC	0.617000													6	246					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168222582	168222582	+	Splice_Site	SNP	G	G	A	rs143425660		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:168222582G>A	ENST00000519560.1	-	10	1356	c.935_splice	c.e10-1	p.R313_splice	SLIT3_ENST00000332966.8_Splice_Site_p.R313_splice|SLIT3_ENST00000404867.3_Splice_Site_p.R313_splice	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	313					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGTTCTAGGCGTCTGGGAAAC	0.512000													5	403					0	0	1	0	0
LRIG2	9860	broad.mit.edu	37	1	113637053	113637053	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:113637053G>A	ENST00000361127.4	+	5	806	c.608G>A	c.(607-609)cGa>cAa	p.R203Q		NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2	203						cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		AACCGTAACCGAATGAGCATG	0.358000													6	463					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133953738	133953738	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr8:133953738C>T	ENST00000220616.4	+	26	5224	c.5184C>T	c.(5182-5184)tgC>tgT	p.C1728C	TG_ENST00000377869.1_Silent_p.C1671C|TG_ENST00000542445.1_Intron	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1728					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TTCTTGCATGCGACCGTGATC	0.522000													10	358					0	0	1	0	0
SPATA13	221178	broad.mit.edu	37	13	24823914	24823914	+	Silent	SNP	C	C	T	rs139541678		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr13:24823914C>T	ENST00000424834.2	+	5	2426	c.1953C>T	c.(1951-1953)tcC>tcT	p.S651S	SPATA13_ENST00000382108.3_Silent_p.S651S|SPATA13_ENST00000382095.4_Silent_p.S26S			Q96N96	SPT13_HUMAN	spermatogenesis associated 13	26	C-terminal tail.				cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			breast(4)|endometrium(2)|large_intestine(9)|lung(4)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		GCCCCATTTCCGTGATAGGTG	0.587000													5	292					0	0	1	0	0
PFKP	5214	broad.mit.edu	37	10	3178679	3178679	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr10:3178679C>T	ENST00000381075.2	+	24	2463	c.2239C>T	c.(2239-2241)Cgg>Tgg	p.R747W	PFKP_ENST00000381072.1_Missense_Mutation_p.R173W|PFKP_ENST00000381125.4_Missense_Mutation_p.R755W	NM_001242339.1	NP_001229268.1	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	755					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		GCTCAAGCTACGGCCCCTCAT	0.592000													7	62					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90499930	90499930	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:90499930G>A	ENST00000325643.5	+	4	594	c.528G>A	c.(526-528)ccG>ccA	p.P176P		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		CCCACCAGCCGCATGGGAAAT	0.637000													11	313					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144889134	144889134	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr8:144889134G>A	ENST00000356994.2	-	17	2234	c.2228C>T	c.(2227-2229)gCg>gTg	p.A743V	SCRIB_ENST00000320476.3_Missense_Mutation_p.A743V|SCRIB_ENST00000377533.3_Missense_Mutation_p.A662V	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	743	Interaction with ARHGEF7.|PDZ 1.|Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CTTGCCGCCCGCAATGCTGAT	0.642000													36	61					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3263663	3263663	+	Missense_Mutation	SNP	A	A	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr8:3263663A>G	ENST00000602557.1	-	16	2710	c.2155T>C	c.(2155-2157)Tcg>Ccg	p.S719P	CSMD1_ENST00000542608.1_Missense_Mutation_p.S718P|CSMD1_ENST00000400186.3_Missense_Mutation_p.S719P|CSMD1_ENST00000537824.1_Missense_Mutation_p.S718P|CSMD1_ENST00000539096.1_Missense_Mutation_p.S718P|CSMD1_ENST00000520002.1_Missense_Mutation_p.S719P|CSMD1_ENST00000602723.1_Missense_Mutation_p.S719P			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	719	Sushi 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AAAGAAACCGAGCTCCCGAGT	0.493000													58	80					0	0	1	0	0
NCAPD3	23310	broad.mit.edu	37	11	134038048	134038048	+	Missense_Mutation	SNP	C	C	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:134038048C>A	ENST00000534548.2	-	27	3480	c.3416G>T	c.(3415-3417)aGt>aTt	p.S1139I		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	1139					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		GAGTAACTCACTGGCGTCCAG	0.493000													11	176					5.50884e-06	5.75573e-06	1	1	0
ADRA2C	152	broad.mit.edu	37	4	3769385	3769385	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:3769385G>A	ENST00000330055.5	+	1	1261	c.1052G>A	c.(1051-1053)cGc>cAc	p.R351H	ADRA2C_ENST00000509482.1_Intron	NM_000683.3	NP_000674.2	P18825	ADA2C_HUMAN	adrenoceptor alpha 2C	351					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	8				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	GCCAGCTCGCGCTCCGTCGAG	0.786000													3	20					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101375374	101375374	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:101375374C>T	ENST00000344327.3	-	2	750	c.326G>A	c.(325-327)gGt>gAt	p.G109D	TRPC6_ENST00000532133.1_Missense_Mutation_p.G109D|TRPC6_ENST00000360497.4_Missense_Mutation_p.G109D|TRPC6_ENST00000348423.4_Missense_Mutation_p.G109D	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	109					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TGGGATGTTACCATATTCAGC	0.483000													280	225					0	0	1	0	0
ZNF443	10224	broad.mit.edu	37	19	12542412	12542412	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:12542412G>A	ENST00000301547.5	-	4	771	c.574C>T	c.(574-576)Cgt>Tgt	p.R192C	CTD-3105H18.16_ENST00000595562.1_Intron	NM_005815.4	NP_005806.2	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	192					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|pancreas(1)|prostate(1)	28						CCATCTCCACGCTGCACTGCC	0.418000													14	454					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170044660	170044660	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:170044660C>T	ENST00000263816.3	-	49	9433	c.9148G>A	c.(9148-9150)Gtc>Atc	p.V3050I		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3050	LDL-receptor class A 24.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding	p.V3050I(1)		biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCATCACAGACGAAGGTTTTA	0.512000													14	474					0	0	1	0	0
IGHV1OR15-9	0	broad.mit.edu	37	15	20169960	20169960	+	RNA	SNP	G	G	A	rs150674714	by1000genomes	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr15:20169960G>A	ENST00000338912.5	-	0	311																											CAGATCTCAGGCTGCTTAGCT	0.527000													6	846					0	0	1	0	0
TAAR6	319100	broad.mit.edu	37	6	132891982	132891982	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:132891982C>T	ENST00000275198.1	+	1	522	c.522C>T	c.(520-522)gaC>gaT	p.D174D		NM_175067.1	NP_778237.1	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	174						plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(19)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		GTGTCTATGACGATGGGCTGG	0.463000													431	295					0	0	1	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724315	38724315	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr14:38724315G>A	ENST00000342213.2	-	1	1259	c.913C>T	c.(913-915)Cgc>Tgc	p.R305C		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	305						integral to membrane	sugar binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		GCCGGCGGGCGCCTGGTGGGC	0.652000													239	232					0	0	1	0	0
RDM1	201299	broad.mit.edu	37	17	34247233	34247233	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr17:34247233G>A	ENST00000394529.3	-	5	1128	c.642C>T	c.(640-642)atC>atT	p.I214I	RDM1_ENST00000431884.2_Silent_p.I204I|RDM1_ENST00000293273.6_Silent_p.I237I|RDM1_ENST00000425909.3_Intron|RDM1_ENST00000591402.1_Intron|RDM1_ENST00000419453.2_Silent_p.I181I	NM_001163130.1	NP_001156602.1	Q8NG50	RDM1_HUMAN	RAD52 motif 1	237					DNA recombination|DNA repair	Cajal body|cytoplasm|nucleolus|PML body	DNA binding|nucleotide binding|RNA binding			breast(1)|kidney(3)|large_intestine(2)|ovary(1)|skin(1)|stomach(1)	9		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TGACACCTACGATGTCTTCAC	0.368000								Other identified genes with known or suspected DNA repair function					9	310					0	0	1	0	0
ESR1	2099	broad.mit.edu	37	6	152420041	152420041	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:152420041G>A	ENST00000440973.1	+	10	2098	c.1728G>A	c.(1726-1728)tcG>tcA	p.S576S	ESR1_ENST00000443427.1_Silent_p.S576S|ESR1_ENST00000544394.1_Intron|ESR1_ENST00000406599.1_Silent_p.S315S|ESR1_ENST00000338799.5_Silent_p.S576S|ESR1_ENST00000456483.2_Silent_p.S464S|ESR1_ENST00000206249.3_Silent_p.S576S	NM_001122742.1	NP_001116214.1	P03372	ESR1_HUMAN	estrogen receptor 1	576	Interaction with AKAP13.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(19)|ovary(1)|prostate(2)|skin(1)	49		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	CTACTTCATCGCATTCCTTGC	0.607000													27	139					0	0	1	0	0
GPR128	84873	broad.mit.edu	37	3	100362231	100362231	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:100362231C>T	ENST00000273352.3	+	7	1088	c.820C>T	c.(820-822)Cgc>Tgc	p.R274C	GPR128_ENST00000475887.1_Intron	NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128	274					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						TTCAAATGTTCGCTTCTCTGT	0.393000													123	420					0	0	1	0	0
RALGPS1	9649	broad.mit.edu	37	9	129728136	129728136	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:129728136C>T	ENST00000259351.5	+	3	338	c.71C>T	c.(70-72)tCg>tTg	p.S24L	RALGPS1_ENST00000394022.3_Missense_Mutation_p.S24L|RALGPS1_ENST00000373434.1_Missense_Mutation_p.S24L|RALGPS1_ENST00000394011.3_Missense_Mutation_p.S24L|RALGPS1_ENST00000480993.1_3'UTR|RALGPS1_ENST00000424082.2_Missense_Mutation_p.S24L|RALGPS1_ENST00000373436.1_Missense_Mutation_p.S24L	NM_014636.2	NP_055451.1	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	24	Poly-Ser.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			kidney(2)|large_intestine(6)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						AGCAGCAGCTCGGACTCTCTG	0.532000													5	371					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414373	20414373	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:20414373G>A	ENST00000380338.4	-	5	757	c.471C>T	c.(469-471)agC>agT	p.S157S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S154S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	157	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S157S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.527000			T	MLL	ALL								5	202					0	0	1	0	0
KCTD10	83892	broad.mit.edu	37	12	109893952	109893952	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:109893952C>T	ENST00000228495.6	-	6	975	c.694G>A	c.(694-696)Gtc>Atc	p.V232I	KCTD10_ENST00000540089.1_Missense_Mutation_p.V51I|KCTD10_ENST00000424763.2_Missense_Mutation_p.V51I|KCTD10_ENST00000538161.1_5'UTR|KCTD10_ENST00000540411.1_Missense_Mutation_p.V206I	NM_031954.3	NP_114160.1	Q9H3F6	BACD3_HUMAN	potassium channel tetramerization domain containing 10	232					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|nucleus|voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	10						GTGGCATAGACGATGGAGGTA	0.468000													5	239					0	0	1	0	0
ZNF554	115196	broad.mit.edu	37	19	2834138	2834138	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:2834138G>A	ENST00000317243.5	+	5	1103	c.905G>A	c.(904-906)gGg>gAg	p.G302E	ZNF554_ENST00000591265.1_3'UTR	NM_001102651.1	NP_001096121.1	Q86TJ5	ZN554_HUMAN	zinc finger protein 554	302					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(3)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGGAAAATGGGCAGTCATTG	0.478000													9	427					0	0	1	0	0
PPEF2	5470	broad.mit.edu	37	4	76787474	76787474	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:76787474C>T	ENST00000286719.7	-	15	2144	c.1788G>A	c.(1786-1788)gcG>gcA	p.A596A		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	596	EF-hand 1.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CAGACTCCACCGCTGCTGCCC	0.522000													8	232					0	0	1	0	0
JMJD7-PLA2G4B	0	broad.mit.edu	37	15	42140039	42140039	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr15:42140039G>A	ENST00000382448.4	+	25	3029	c.3020G>A	c.(3019-3021)cGg>cAg	p.R1007Q	PLA2G4B_ENST00000452633.1_Missense_Mutation_p.R776Q|JMJD7-PLA2G4B_ENST00000458483.1_Missense_Mutation_p.R776Q|JMJD7-PLA2G4B_ENST00000342159.4_3'UTR	NM_005090.3	NP_005081.1	P0C869	PA24B_HUMAN		776					arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						CAGCGGAGGCGGCAGCGCAGG	0.627000													14	95					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628283	29628283	+	Silent	SNP	G	G	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr20:29628283G>C	ENST00000278882.3	+	6	665	c.285G>C	c.(283-285)ggG>ggC	p.G95G	FRG1B_ENST00000439954.2_Silent_p.G100G|FRG1B_ENST00000358464.4_Silent_p.G95G														p.G95G(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGAAGCAGGGGACATAGAAG	0.378000													15	465					0	0	1	0	0
DPY19L2P1	0	broad.mit.edu	37	7	35144338	35144338	+	RNA	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:35144338G>A	ENST00000436258.1	-	0	1728																											AATGGCAAGGGCAGTAAACGC	0.348000													150	180					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30315575	30315575	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr10:30315575G>A	ENST00000375377.1	-	3	3603	c.3502C>T	c.(3502-3504)Cgg>Tgg	p.R1168W		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	1168										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						TGAGGAGCCCGCCTGGCACTG	0.602000													22	236					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681963	100681963	+	Silent	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:100681963T>C	ENST00000306151.4	+	3	7330	c.7266T>C	c.(7264-7266)gtT>gtC	p.V2422V		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2422	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CAACTCCTGTTGACACCAGCA	0.512000													12	2294					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152476229	152476229	+	Silent	SNP	G	G	A	rs144673752	by1000genomes	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:152476229G>A	ENST00000397345.3	-	73	10810	c.10608C>T	c.(10606-10608)ggC>ggT	p.G3536G	NEB_ENST00000172853.10_Silent_p.G3293G|NEB_ENST00000604864.1_Silent_p.G3536G|NEB_ENST00000603639.1_Silent_p.G3536G|NEB_ENST00000427231.2_Silent_p.G3536G|NEB_ENST00000409198.1_Silent_p.G3293G	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	3536					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTGCTCGGGCGCCAATGTGGT	0.438000													7	257					0	0	1	0	0
PCDHGA1	0	broad.mit.edu	37	5	140712187	140712187	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:140712187G>A	ENST00000517417.1	+	1	1936	c.1936G>A	c.(1936-1938)Gtc>Atc	p.V646I	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.V646I	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGGTGGCCGTCCAGGACCA	0.706000													8	291					0	0	1	0	0
USP29	0	broad.mit.edu	37	19	57642144	57642144	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:57642144G>A	ENST00000254181.4	+	4	2555	c.2101G>A	c.(2101-2103)Gta>Ata	p.V701I	USP29_ENST00000598197.1_Missense_Mutation_p.V701I	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	701					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAATACATTCGTAGAGTTCAA	0.438000													7	221					0	0	1	0	0
VARS	7407	broad.mit.edu	37	6	31749280	31749280	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:31749280G>A	ENST00000375663.3	-	21	2962	c.2522C>T	c.(2521-2523)aCg>aTg	p.T841M	VARS_ENST00000482996.1_5'UTR	NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	841					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	CAGCCTGCCCGTGAGCTTCAG	0.642000													5	87					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769889	31769889	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:31769889G>A	ENST00000240587.4	-	2	1137	c.810C>T	c.(808-810)gaC>gaT	p.D270D		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	270					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					CCTTCTGGGCGTCTTCCTTCC	0.512000													25	556					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58247457	58247457	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr15:58247457C>T	ENST00000249750.4	-	13	2262	c.1495G>A	c.(1495-1497)Ggc>Agc	p.G499S	ALDH1A2_ENST00000558231.1_Missense_Mutation_p.G470S|ALDH1A2_ENST00000537372.1_Missense_Mutation_p.G478S|ALDH1A2_ENST00000347587.3_Missense_Mutation_p.G461S|ALDH1A2_ENST00000559517.1_Missense_Mutation_p.G403S	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	499					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TCCCGCAAGCCAAATTCTCCC	0.542000													9	372					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856761	53856761	+	Missense_Mutation	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:53856761T>C	ENST00000458035.1	+	4	2950	c.2833T>C	c.(2833-2835)Tgt>Cgt	p.C945R	ZNF845_ENST00000595091.1_Missense_Mutation_p.C945R	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	945					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.C945R(1)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						ACCTTACAAGTGTAATGAATG	0.348000													7	139					0	0	1	0	0
RP11-480I12.7	0	broad.mit.edu	37	1	202842822	202842822	+	RNA	SNP	C	C	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:202842822C>A	ENST00000456105.2	+	0	774					NR_002929.2																						ACACAGCCATCCAGGCTGTGC	0.572000													72	57					7.2426e-40	7.87606e-40	1	1	0
KPRP	448834	broad.mit.edu	37	1	152733041	152733041	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:152733041G>A	ENST00000368773.1	+	2	1035	c.977G>A	c.(976-978)cGa>cAa	p.R326Q	KPRP_ENST00000606109.1_Missense_Mutation_p.R326Q	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	326	Pro-rich.					cytoplasm		p.R326Q(1)		NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCAAGTGCCGAATCGAGATT	0.617000													8	231					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11047546	11047546	+	RNA	SNP	C	C	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr21:11047546C>A	ENST00000470054.1	-	0	708									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTATGATACCCTTTGTCACAC	0.338000													59	1497					1.30998e-17	1.4163e-17	1	1	0
P2RX7	5027	broad.mit.edu	37	12	121600237	121600237	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:121600237C>T	ENST00000546057.1	+	5	590	c.447C>T	c.(445-447)acC>acT	p.T149T	P2RX7_ENST00000328963.5_Intron|P2RX7_ENST00000377162.2_Silent_p.T149T|P2RX7_ENST00000535250.1_Silent_p.T59T|P2RX7_ENST00000541446.1_5'UTR|P2RX7_ENST00000443520.3_3'UTR	NM_002562.5	NP_002553.3	A8K2Z0	A8K2Z0_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 7	149						integral to membrane	ATP binding|ion channel activity|receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|stomach(1)	19	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GAATTCAGACCGGAAGGTGTG	0.552000													9	179					0	0	1	0	0
DCK	1633	broad.mit.edu	37	4	71895154	71895154	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:71895154C>T	ENST00000504952.1	+	8	1137	c.939C>T	c.(937-939)ttC>ttT	p.F313F	DCK_ENST00000286648.5_3'UTR|DCK_ENST00000504730.1_3'UTR			P27707	DCK_HUMAN	deoxycytidine kinase	0					purine base metabolic process|purine-containing compound salvage|pyrimidine base metabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol|nucleus	ATP binding|deoxycytidine kinase activity|drug binding|phosphotransferase activity, alcohol group as acceptor|protein homodimerization activity			endometrium(2)|large_intestine(3)|lung(3)|ovary(1)	9			Lung(101;0.235)		Cladribine(DB00242)|Clofarabine(DB00631)|Decitabine(DB01262)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Pemetrexed(DB00642)|Zalcitabine(DB00943)	TGTGTATCTTCGTAACTTCAT	0.313000													6	213					0	0	1	0	0
HNRNPH1	3187	broad.mit.edu	37	5	179044053	179044053	+	Splice_Site	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:179044053G>A	ENST00000356731.5	-	9	2651	c.1117_splice	c.e9+1	p.Y372_splice	HNRNPH1_ENST00000329433.6_Splice_Site_p.Y372_splice|HNRNPH1_ENST00000511300.2_Silent_p.Y102Y|HNRNPH1_ENST00000510411.1_Silent_p.Y372Y|HNRNPH1_ENST00000442819.2_Splice_Site_p.Y372_splice|HNRNPH1_ENST00000393432.4_Splice_Site_p.Y372_splice			P31943	HNRH1_HUMAN	heterogeneous nuclear ribonucleoprotein H1 (H)	372	2 X 16 AA Gly-rich approximate repeats.|2 X 19 AA perfect repeats.				regulation of RNA splicing	actin cytoskeleton|catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|poly(U) RNA binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|skin(1)	14						TTTGGCTACCGTAAGCACCAC	0.373000													9	550					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64453315	64453315	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:64453315G>A	ENST00000265459.6	-	6	1416	c.955C>T	c.(955-957)Cgc>Tgc	p.R319C	NRXN2_ENST00000377551.1_Missense_Mutation_p.R319C|NRXN2_ENST00000409571.1_Missense_Mutation_p.R319C|NRXN2_ENST00000377559.3_Missense_Mutation_p.R295C	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	319	Laminin G-like 2.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						TGCAGGGTGCGGAAGGCCAGT	0.567000													8	323					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45920611	45920611	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr20:45920611C>T	ENST00000311275.7	-	6	782	c.529G>A	c.(529-531)Gtt>Att	p.V177I	ZMYND8_ENST00000360911.3_Missense_Mutation_p.V172I|ZMYND8_ENST00000396281.4_Missense_Mutation_p.V177I|ZMYND8_ENST00000352431.2_Missense_Mutation_p.V197I|ZMYND8_ENST00000446994.2_Missense_Mutation_p.V114I|ZMYND8_ENST00000372023.3_Missense_Mutation_p.V172I|ZMYND8_ENST00000540497.1_Missense_Mutation_p.V172I|ZMYND8_ENST00000355972.4_Missense_Mutation_p.V177I|ZMYND8_ENST00000461685.1_Missense_Mutation_p.V197I|ZMYND8_ENST00000262975.4_Missense_Mutation_p.V177I|ZMYND8_ENST00000536340.1_Missense_Mutation_p.V204I|ZMYND8_ENST00000468376.2_5'UTR|ZMYND8_ENST00000458360.2_Missense_Mutation_p.V172I|ZMYND8_ENST00000471951.2_Missense_Mutation_p.V197I			Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	177	Bromo.						protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TCCAATGGAACGGGCTTCTGG	0.433000													14	396					0	0	1	0	0
ALS2CR12	130540	broad.mit.edu	37	2	202216069	202216069	+	Missense_Mutation	SNP	C	C	T	rs142397497		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:202216069C>T	ENST00000405148.2	-	2	502	c.59G>A	c.(58-60)cGg>cAg	p.R20Q	ALS2CR12_ENST00000448967.1_5'UTR|ALS2CR12_ENST00000392257.3_Missense_Mutation_p.R20Q|ALS2CR12_ENST00000439709.1_Missense_Mutation_p.R20Q|ALS2CR12_ENST00000286190.5_Missense_Mutation_p.R20Q	NM_139163.2	NP_631902.2	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12	20					regulation of GTPase activity		protein binding	p.R20Q(1)		NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)	21						GATTAGCTTCCGTGGTCCCAA	0.557000													35	217					0	0	1	0	0
PCDHB16	0	broad.mit.edu	37	5	140563751	140563751	+	Silent	SNP	G	G	A	rs17844655		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:140563751G>A	ENST00000361016.2	+	1	2772	c.1617G>A	c.(1615-1617)ccG>ccA	p.P539P		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		539	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGGCTCCCCGGCTTTGAGCA	0.682000													49	171					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6828153	6828153	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:6828153C>T	ENST00000304076.2	+	10	1088	c.994C>T	c.(994-996)Cga>Tga	p.R332*	VAV1_ENST00000602142.1_Nonsense_Mutation_p.R332*|VAV1_ENST00000599806.1_Nonsense_Mutation_p.R277*|VAV1_ENST00000596764.1_Nonsense_Mutation_p.R300*|VAV1_ENST00000539284.1_Nonsense_Mutation_p.R235*	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	332	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						GCCTATGCAGCGAGTTCTCAA	0.557000													48	150					0	0	1	0	0
GPR12	0	broad.mit.edu	37	13	27333439	27333439	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr13:27333439C>T	ENST00000405846.3	-	2	747	c.526G>A	c.(526-528)Gtc>Atc	p.V176I	GPR12_ENST00000381436.2_Missense_Mutation_p.V176I	NM_005288.3	NP_005279.1	P47775	GPR12_HUMAN	G protein-coupled receptor 12	176						integral to plasma membrane				endometrium(7)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		CAGCCCATGACGGGCAGCAGC	0.597000													50	82					0	0	1	0	0
ZNF454	285676	broad.mit.edu	37	5	178391963	178391963	+	Silent	SNP	C	C	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:178391963C>A	ENST00000320129.3	+	5	861	c.558C>A	c.(556-558)gtC>gtA	p.V186V	ZNF454_ENST00000519564.1_Silent_p.V186V	NM_001178090.1|NM_182594.2	NP_001171561.1|NP_872400.2	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.V186V(1)		breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(11)|lung(18)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)	46	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		GTGGAAAAGTCTTCTCTAAGA	0.343000													24	261					6.44725e-10	6.87093e-10	1	1	0
SPTBN1	0	broad.mit.edu	37	2	54753681	54753681	+	Silent	SNP	G	G	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:54753681G>C	ENST00000356805.4	+	2	407	c.126G>C	c.(124-126)cgG>cgC	p.R42R	AC092839.3_ENST00000433475.1_RNA	NM_003128.2	NP_003119.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	42	Actin-binding.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			TTTTTGAGCGGTCCCGCATCA	0.537000													55	214					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83128600	83128600	+	Missense_Mutation	SNP	G	G	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chrX:83128600G>T	ENST00000329312.4	+	4	921	c.884G>T	c.(883-885)aGc>aTc	p.S295I		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	295					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						GCAAAGAAAAGCTCTGATGCT	0.308000													95	38					1.49228e-48	1.62755e-48	1	1	0
PGLYRP2	114770	broad.mit.edu	37	19	15587252	15587252	+	Missense_Mutation	SNP	T	T	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:15587252T>A	ENST00000292609.4	-	2	358	c.229A>T	c.(229-231)Aat>Tat	p.N77Y	PGLYRP2_ENST00000340880.4_Missense_Mutation_p.N77Y			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	77					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						TCTGTAGCATTGAGGCTCCAT	0.577000													6	154					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47879967	47879967	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr20:47879967G>A	ENST00000396105.1	-	6	2451	c.2205C>T	c.(2203-2205)acC>acT	p.T735T	ZNFX1_ENST00000371754.4_Silent_p.T735T|ZNFX1_ENST00000371752.1_Silent_p.T735T	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	735							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TGCACTCCAGGGTCTTGGCTC	0.498000													16	112					0	0	1	0	0
HTRA1	5654	broad.mit.edu	37	10	124273729	124273729	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr10:124273729G>A	ENST00000368984.3	+	9	1425	c.1297G>A	c.(1297-1299)Gtc>Atc	p.V433I		NM_002775.4	NP_002766.1	Q92743	HTRA1_HUMAN	HtrA serine peptidase 1	433	PDZ.				proteolysis|regulation of cell growth	extracellular space	insulin-like growth factor binding|serine-type endopeptidase activity			endometrium(1)|kidney(1)|large_intestine(8)|lung(7)	17		all_neural(114;0.0765)|Lung NSC(174;0.133)|all_lung(145;0.163)|Breast(234;0.238)				GGAAAACGACGTCATAATCAG	0.493000													23	1062					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11758761	11758761	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:11758761C>T	ENST00000381486.2	+	22	4060	c.3760C>T	c.(3760-3762)Cgc>Tgc	p.R1254C	GREB1_ENST00000234142.5_Missense_Mutation_p.R1254C|GREB1_ENST00000396123.1_Missense_Mutation_p.R252C	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1254						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CAAGGCCTGCCGCCAGCCACC	0.672000													35	71					0	0	1	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617940	111617940	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:111617940C>T	ENST00000374667.3	-	1	1299	c.271G>A	c.(271-273)Gac>Aac	p.D91N		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	91						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TTGCGGGTGTCGCCAGCGTCG	0.652000													167	186					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85973848	85973848	+	Missense_Mutation	SNP	G	G	A	rs144225118		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr10:85973848G>A	ENST00000372117.3	+	17	2154	c.2051G>A	c.(2050-2052)cGg>cAg	p.R684Q	CDHR1_ENST00000332904.3_Intron|CDHR1_ENST00000440770.2_Missense_Mutation_p.R388Q	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	684	Cadherin 6.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						ACCCTCTCCCGGAGCCCCATG	0.587000													8	528					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9036163	9036163	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:9036163G>A	ENST00000383836.3	-	19	2699	c.2272C>T	c.(2272-2274)Cgg>Tgg	p.R758W	SRGAP3_ENST00000360413.3_Missense_Mutation_p.R734W	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	758	SH3.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		CGCGGGGACCGCCCCATGTAG	0.602000			T	RAF1	pilocytic astrocytoma								70	207					0	0	1	0	0
TXNDC2	0	broad.mit.edu	37	18	9886894	9886894	+	Missense_Mutation	SNP	A	A	G	rs146821851		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr18:9886894A>G	ENST00000306084.6	+	2	617	c.418A>G	c.(418-420)Aaa>Gaa	p.K140E	TXNDC2_ENST00000426718.3_3'UTR|TXNDC2_ENST00000536353.2_Missense_Mutation_p.K73E|TXNDC2_ENST00000584255.1_3'UTR|TXNDC2_ENST00000357775.4_Missense_Mutation_p.K73E	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	140	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity	p.K140E(2)|p.K73E(2)		NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						GTCCTCAGAAAAAGCCATCCA	0.547000													7	585					0	0	1	0	0
SLC1A5	6510	broad.mit.edu	37	19	47290737	47290737	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:47290737G>A	ENST00000542575.2	-	1	1114	c.486C>T	c.(484-486)atC>atT	p.I162I		NM_005628.2	NP_005619.1	Q15758	AAAT_HUMAN	solute carrier family 1 (neutral amino acid transporter), member 5	162					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(2)|stomach(1)	13		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	CGGAGGCGTTGATGGCGGCGG	0.701000													8	24					0	0	1	0	0
SSTR3	0	broad.mit.edu	37	22	37603719	37603719	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr22:37603719C>T	ENST00000328544.3	-	2	657	c.124G>A	c.(124-126)Gtc>Atc	p.V42I	SSTR3_ENST00000402501.1_Missense_Mutation_p.V42I	NM_001051.3	NP_001042.1	P32745	SSR3_HUMAN	somatostatin receptor 3	42					G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	14						ACGCCACTGACGGCCAGCCCT	0.672000													23	255					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43527833	43527833	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr15:43527833C>T	ENST00000220420.5	-	10	1555	c.1548G>A	c.(1546-1548)ccG>ccA	p.P516P	TGM5_ENST00000349114.4_Silent_p.P434P	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	516					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CCATGTTGGGCGGGTCGAGCA	0.567000													22	104					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	110221776	110221776	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:110221776G>A	ENST00000399132.1	-	3	860	c.330C>T	c.(328-330)atC>atT	p.I110I	COL25A1_ENST00000399126.1_Silent_p.I110I|COL25A1_ENST00000399127.1_Silent_p.I110I	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	110						collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CTTCTCTTGCGATTCTTATTT	0.388000													12	249					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29609320	29609320	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:29609320C>T	ENST00000323874.8	+	12	2111	c.2001C>T	c.(1999-2001)gcC>gcT	p.A667A	PTPRU_ENST00000345512.3_Silent_p.A667A|PTPRU_ENST00000415600.2_3'UTR|PTPRU_ENST00000373779.3_Silent_p.A667A|PTPRU_ENST00000356870.3_Silent_p.A667A|PTPRU_ENST00000460170.2_Silent_p.A667A|PTPRU_ENST00000428026.2_Silent_p.A667A			Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	667	Fibronectin type-III 4.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		ACTTCGGGGCCGAACTGGCGG	0.657000													5	302					0	0	1	0	0
CEACAM8	1088	broad.mit.edu	37	19	43098947	43098947	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:43098947G>A	ENST00000244336.5	-	1	135	c.34C>T	c.(34-36)Cgc>Tgc	p.R12C	LIPE-AS1_ENST00000594688.1_RNA|LIPE-AS1_ENST00000594624.2_RNA|CEACAM8_ENST00000599005.1_Missense_Mutation_p.R12C	NM_001816.3	NP_001807.2	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 8	12					immune response	anchored to membrane|extracellular space|integral to plasma membrane				endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	16		Prostate(69;0.00899)				CAGGGGATGCGCCATCTGCAG	0.612000													215	257					0	0	1	0	0
PRSS3P2	0	broad.mit.edu	37	7	142482242	142482242	+	RNA	SNP	G	G	A	rs143538588	by1000genomes	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:142482242G>A	ENST00000603901.1	+	0	622					NR_001296.3																						GGTCTGCAATGGACAGCTTCA	0.493000													6	203					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228402610	228402610	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:228402610G>A	ENST00000570156.2	+	5	1713	c.1639G>A	c.(1639-1641)Ggc>Agc	p.G547S	OBSCN_ENST00000422127.1_Missense_Mutation_p.G547S|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000284548.11_Missense_Mutation_p.G547S	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	547	Fibronectin type-III 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CACTATCGACGGCTACCTGGT	0.592000													4	130					0	0	1	0	0
PABPC5	140886	broad.mit.edu	37	X	90691366	90691366	+	Missense_Mutation	SNP	A	A	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chrX:90691366A>T	ENST00000312600.3	+	2	1004	c.790A>T	c.(790-792)Atc>Ttc	p.I264F	PABPC5_ENST00000373105.1_Missense_Mutation_p.I100F	NM_080832.2	NP_543022.1	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	264	RRM 3.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(1)|pancreas(1)	42						TGGAAAGTCCATCGATGGAAA	0.458000													52	117					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12123822	12123822	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:12123822G>A	ENST00000379388.2	+	4	4126	c.3794G>A	c.(3793-3795)cGt>cAt	p.R1265H		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	1265					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				TGGCCCCAGCGTAGTGAAACC	0.453000													187	221					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547138	132547138	+	Silent	SNP	A	A	G	rs35873108	byFrequency	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:132547138A>G	ENST00000333577.4	+	48	8443	c.8334A>G	c.(8332-8334)caA>caG	p.Q2778Q	EP400_ENST00000330386.6_Silent_p.Q2661Q|EP400_ENST00000389562.2_Silent_p.Q2741Q|EP400_ENST00000332482.4_Silent_p.Q2705Q|EP400_ENST00000389561.2_Silent_p.Q2742Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2778	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2741Q(3)|p.Q2742Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcaacagcagcagc	0.602000													8	222					0	0	1	0	0
IRX6	79190	broad.mit.edu	37	16	55362757	55362757	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr16:55362757G>A	ENST00000290552.7	+	5	2199	c.867G>A	c.(865-867)gcG>gcA	p.A289A	RP11-26L20.3_ENST00000558730.2_RNA	NM_024335.2	NP_077311.2	P78412	IRX6_HUMAN	iroquois homeobox 6	289						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(2)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33						GAAAGGGCGCGCAGTCACTGC	0.657000													6	323					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168098211	168098211	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:168098211G>A	ENST00000519560.1	-	34	4538	c.4119C>T	c.(4117-4119)ctC>ctT	p.L1373L	SLIT3_ENST00000332966.8_Silent_p.L1380L|SLIT3_ENST00000404867.3_Silent_p.L1373L	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1373	EGF-like 8.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACCTGTGGCCGAGGCAGGGGT	0.672000													5	167					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47614284	47614284	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:47614284G>A	ENST00000371891.3	+	12	1406	c.1375G>A	c.(1375-1377)Ggg>Agg	p.G459R	CYP4A22_ENST00000485117.1_3'UTR|CYP4A22_ENST00000371890.3_Missense_Mutation_p.G361R|CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	459						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GAACTGCATCGGGAAACAATT	0.602000													6	397					0	0	1	0	0
PCDHA13	0	broad.mit.edu	37	5	140263647	140263647	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:140263647C>T	ENST00000289272.2	+	1	1794	c.1794C>T	c.(1792-1794)gaC>gaT	p.D598D	PCDHA4_ENST00000530339.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA13_ENST00000409494.1_Silent_p.D598D|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGGTGGACGCCGATTCGG	0.692000													12	541					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130507312	130507312	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:130507312C>T	ENST00000314830.8	-	7	1444	c.1331G>A	c.(1330-1332)cGc>cAc	p.R444H	SH2D3C_ENST00000420366.1_Missense_Mutation_p.R286H|SH2D3C_ENST00000429553.1_Missense_Mutation_p.R90H|SH2D3C_ENST00000373274.3_Missense_Mutation_p.R284H|SH2D3C_ENST00000373277.4_Missense_Mutation_p.R287H|SH2D3C_ENST00000471939.1_5'UTR|SH2D3C_ENST00000373276.3_Missense_Mutation_p.R376H	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	444					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						ACTGGAACGGCGGGCGACAGG	0.647000													127	157					0	0	1	0	0
CUL7	9820	broad.mit.edu	37	6	43018136	43018136	+	Splice_Site	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:43018136C>T	ENST00000535468.1	-	5	1572	c.1485_splice	c.e5-1	p.V496_splice	CUL7_ENST00000265348.3_Splice_Site_p.V412_splice	NM_001168370.1|NM_014780.4	NP_001161842.1|NP_055595.2	Q14999	CUL7_HUMAN	cullin 7	412					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(8)|liver(1)|lung(11)|ovary(3)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	49			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			TCCCAAAATACCTGGAGCATA	0.537000													76	87					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													8	139					0	0	1	0	0
CSPG5	10675	broad.mit.edu	37	3	47618381	47618381	+	Missense_Mutation	SNP	T	T	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:47618381T>A	ENST00000383738.2	-	2	3233	c.1135A>T	c.(1135-1137)Agt>Tgt	p.S379C	CSPG5_ENST00000264723.4_Missense_Mutation_p.S379C|CSPG5_ENST00000456150.1_Missense_Mutation_p.S241C	NM_001206943.1|NM_001206945.1	NP_001193872.1|NP_001193874.1	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan C)	379	EGF-like.				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(2)	22				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TGACAGTAACTTGGGAAGAGG	0.592000													49	875					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	40999870	40999870	+	Missense_Mutation	SNP	G	G	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:40999870G>T	ENST00000399564.4	-	40	4944	c.4494C>A	c.(4492-4494)aaC>aaA	p.N1498K	MROH2B_ENST00000506092.2_Missense_Mutation_p.N1053K	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GAATTTCCTGGTTTTTCTTGG	0.468000													8	320					5.68852e-11	6.13243e-11	1	1	0
SPTBN5	51332	broad.mit.edu	37	15	42172014	42172014	+	Missense_Mutation	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr15:42172014T>C	ENST00000320955.6	-	15	3087	c.2860A>G	c.(2860-2862)Agc>Ggc	p.S954G		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	954					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GCAGAGCTGCTGACCTCAGCC	0.562000													39	156					0	0	1	0	0
RP11-80F22.15	0	broad.mit.edu	37	16	34739676	34739676	+	RNA	SNP	G	G	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr16:34739676G>T	ENST00000562591.1	-	0	246					NR_034019.1																						ATGCTCCAAAGAGATGTCCCA	0.408000													47	51					2.37825e-27	2.57874e-27	1	1	0
VAX1	11023	broad.mit.edu	37	10	118896117	118896117	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr10:118896117G>A	ENST00000277905.2	-	2	539	c.295C>T	c.(295-297)Cgg>Tgg	p.R99W	VAX1_ENST00000369206.5_Missense_Mutation_p.R99W	NM_199131.2	NP_954582.1	Q5SQQ9	VAX1_HUMAN	ventral anterior homeobox 1	99						nucleus	sequence-specific DNA binding	p.R99W(4)		endometrium(1)|large_intestine(1)|lung(8)|ovary(2)	12				all cancers(201;0.0108)		CTCTTAGGCCGGTCCAAGTCC	0.657000													5	253					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371102	240371102	+	Missense_Mutation	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:240371102T>C	ENST00000319653.9	+	5	3220	c.2990T>C	c.(2989-2991)aTa>aCa	p.I997T		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	997	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GGAGCGGGCATACCCCCTCCG	0.697000													31	88					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47578839	47578839	+	Missense_Mutation	SNP	G	G	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:47578839G>T	ENST00000273859.3	+	19	3685	c.3416G>T	c.(3415-3417)gGa>gTa	p.G1139V		NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1139					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						GGATTTTCAGGAACATCCATG	0.418000													364	789					2.55502e-134	2.80301e-134	1	1	0
ERG	2078	broad.mit.edu	37	21	39755757	39755757	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr21:39755757G>A	ENST00000442448.1	-	11	1228	c.957C>T	c.(955-957)aaC>aaT	p.N319N	ERG_ENST00000398897.1_Silent_p.N220N|ERG_ENST00000398919.2_Silent_p.N343N|ERG_ENST00000417133.2_Silent_p.N343N|ERG_ENST00000398905.1_Silent_p.N312N|ERG_ENST00000288319.7_Silent_p.N336N|ERG_ENST00000398907.1_Silent_p.N313N|ERG_ENST00000398911.1_Silent_p.N319N|ERG_ENST00000453032.2_Silent_p.N244N|ERG_ENST00000398910.1_Silent_p.N320N	NM_004449.4	NP_004440.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog	343					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				TGAACTCCCCGTTGGTGCCTT	0.607000			T	"""EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"""	"""Ewing sarcoma, prostate, AML"""								163	123					0	0	1	0	0
GRIN1	2902	broad.mit.edu	37	9	140036550	140036550	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:140036550G>A	ENST00000371561.3	+	2	1441	c.344G>A	c.(343-345)cGc>cAc	p.R115H	GRIN1_ENST00000371559.4_Missense_Mutation_p.R115H|GRIN1_ENST00000371560.3_Missense_Mutation_p.R115H|GRIN1_ENST00000371550.4_Missense_Mutation_p.R115H|GRIN1_ENST00000315048.3_Missense_Mutation_p.R115H|GRIN1_ENST00000371553.3_Missense_Mutation_p.R115H|GRIN1_ENST00000350902.5_Missense_Mutation_p.R115H|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000371546.4_Missense_Mutation_p.R115H|GRIN1_ENST00000371555.4_Missense_Mutation_p.R115H	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	115					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	GGCTTCTACCGCATACCCGTG	0.627000													6	557					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33566734	33566734	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:33566734G>A	ENST00000321505.4	+	2	2484	c.2304G>A	c.(2302-2304)acG>acA	p.T768T	KIAA1549L_ENST00000389726.3_Silent_p.T774T|KIAA1549L_ENST00000265654.5_Silent_p.T774T					KIAA1549-like																		GAGCATCCACGCCACGCCCAC	0.597000													269	173					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124377583	124377583	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr10:124377583C>T	ENST00000338354.3	+	38	4661	c.4555C>T	c.(4555-4557)Cga>Tga	p.R1519*	DMBT1_ENST00000344338.3_Nonsense_Mutation_p.R1509*|DMBT1_ENST00000368956.2_Nonsense_Mutation_p.R891*|DMBT1_ENST00000330163.4_Nonsense_Mutation_p.R891*|DMBT1_ENST00000368955.3_Nonsense_Mutation_p.R1509*|DMBT1_ENST00000368909.3_Nonsense_Mutation_p.R1519*|DMBT1_ENST00000359586.6_Nonsense_Mutation_p.R370*			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1519	SRCR 12.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGACAGGTGTCGAGGCCGAGT	0.572000													43	1588					0	0	1	0	0
COL6A2	0	broad.mit.edu	37	21	47545713	47545713	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr21:47545713G>A	ENST00000300527.4	+	26	2088	c.1984G>A	c.(1984-1986)Gtg>Atg	p.V662M	COL6A2_ENST00000397763.1_Missense_Mutation_p.V662M|COL6A2_ENST00000409416.1_Missense_Mutation_p.V662M|COL6A2_ENST00000310645.5_Missense_Mutation_p.V662M|COL6A2_ENST00000357838.4_Missense_Mutation_p.V662M	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	662	Nonhelical region.|VWFA 2.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		GCGTGTGGGCGTGGTGCAGTA	0.647000													41	81					0	0	1	0	0
RP11-252A24.2	0	broad.mit.edu	37	16	74372644	74372644	+	RNA	SNP	A	A	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr16:74372644A>G	ENST00000429810.2	-	0	1552																											TACCCTTGTCAGGGGGAACAA	0.443000													7	178					0	0	1	0	0
GLI4	2738	broad.mit.edu	37	8	144358694	144358694	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr8:144358694G>A	ENST00000340042.1	+	4	936	c.851G>A	c.(850-852)cGc>cAc	p.R284H	GLI4_ENST00000523812.1_3'UTR|GLI4_ENST00000523522.1_Missense_Mutation_p.R284H	NM_138465.3	NP_612474.1	P10075	GLI4_HUMAN	GLI family zinc finger 4	284						nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(1)|lung(5)	9	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			AACCTGGTGCGCCACCAGCGG	0.657000													4	125					0	0	1	0	0
PRR14	78994	broad.mit.edu	37	16	30667562	30667562	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr16:30667562G>A	ENST00000542965.2	+	11	2144	c.1688G>A	c.(1687-1689)cGg>cAg	p.R563Q	PRR14_ENST00000300835.4_Missense_Mutation_p.R563Q			Q9BWN1	PRR14_HUMAN	proline rich 14	563										breast(3)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	18			Colorectal(24;0.103)			CTCCAGCAGCGGCTGGAGGAG	0.637000													6	355					0	0	1	0	0
GOLGA2B	0	broad.mit.edu	37	12	100550723	100550723	+	RNA	SNP	G	G	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:100550723G>C	ENST00000397112.4	-	0	2098					NR_036632.1															large_intestine(1)|lung(3)	4						CAAGCTACTGGGGGGCGGGGG	0.647000													62	79					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117335865	117335865	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:117335865G>A	ENST00000321322.6	-	17	3239	c.3238C>T	c.(3238-3240)Cgg>Tgg	p.R1080W	DSCAML1_ENST00000527706.1_Missense_Mutation_p.R810W	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1020	Fibronectin type-III 2.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity	p.R1080W(1)		breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TGGTAGCCCCGGATGACACCG	0.582000													20	245					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175897739	175897739	+	Missense_Mutation	SNP	A	A	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:175897739A>C	ENST00000359240.3	+	5	1733	c.1063A>C	c.(1063-1065)Ata>Cta	p.I355L	ADAM29_ENST00000514159.1_Missense_Mutation_p.I355L|ADAM29_ENST00000404450.4_Missense_Mutation_p.I355L|ADAM29_ENST00000445694.1_Missense_Mutation_p.I355L	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	355	Peptidase M12B.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		ACCTAGATGCATAATGCATGA	0.383000													127	464					0	0	1	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74904292	74904292	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:74904292C>T	ENST00000289575.5	+	9	1500	c.1105C>T	c.(1105-1107)Cgc>Tgc	p.R369C	SLCO2B1_ENST00000428359.2_Missense_Mutation_p.R347C|SLCO2B1_ENST00000341411.4_Missense_Mutation_p.R142C|SLCO2B1_ENST00000531756.1_Missense_Mutation_p.R114C|SLCO2B1_ENST00000454962.2_Missense_Mutation_p.R142C|SLCO2B1_ENST00000532236.1_Missense_Mutation_p.R253C|SLCO2B1_ENST00000525650.1_Missense_Mutation_p.R225C	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	369					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	GCAGACCCTACGCCACCCCAT	0.642000													12	326					0	0	1	0	0
PCDHA4	0	broad.mit.edu	37	5	140188137	140188137	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:140188137C>T	ENST00000530339.1	+	1	1365	c.1365C>T	c.(1363-1365)ttC>ttT	p.F455F	PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Silent_p.F455F|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000356878.4_Silent_p.F455F	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCGGCGTTCGCGCAGCCCG	0.657000													8	363					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137721880	137721880	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:137721880G>A	ENST00000371817.3	+	64	5540	c.5126G>A	c.(5125-5127)cGt>cAt	p.R1709H		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1709	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding	p.R1709H(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GAATTCAAGCGTGGGAAACTG	0.537000													9	183					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122002846	122002846	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:122002846C>T	ENST00000498619.1	+	7	2513	c.2075C>T	c.(2074-2076)cCg>cTg	p.P692L	CASR_ENST00000296154.5_Missense_Mutation_p.P682L|CASR_ENST00000490131.1_Missense_Mutation_p.P682L	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	682					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CTGCGCCAGCCGGCCTTTGGC	0.607000													97	285					0	0	1	0	0
IPO9	55705	broad.mit.edu	37	1	201843427	201843427	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:201843427G>A	ENST00000361565.4	+	21	2829	c.2760G>A	c.(2758-2760)ctG>ctA	p.L920L		NM_018085.4	NP_060555.2	Q96P70	IPO9_HUMAN	importin 9	920					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	38						TCCTAAAGCTGATCATCAACG	0.522000													15	450					0	0	1	0	0
TSPYL6	388951	broad.mit.edu	37	2	54482977	54482977	+	Silent	SNP	C	C	T	rs114346583	by1000genomes	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:54482977C>T	ENST00000317802.7	-	1	432	c.312G>A	c.(310-312)tcG>tcA	p.S104S	ACYP2_ENST00000394666.3_Intron|ACYP2_ENST00000607452.1_Intron|ACYP2_ENST00000606865.1_Intron|ACYP2_ENST00000303536.4_Intron	NM_001003937.2	NP_001003937.2	Q8N831	TSYL6_HUMAN	TSPY-like 6	104					nucleosome assembly	nucleus				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(1)|ovary(1)|skin(1)|stomach(2)	20						CAGTTGTCAGCGAGGCAGAGG	0.622000													10	230					0	0	1	0	0
ARHGAP15	55843	broad.mit.edu	37	2	143986187	143986187	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:143986187C>T	ENST00000409869.1	+	6	511	c.334C>T	c.(334-336)Cga>Tga	p.R112*	ARHGAP15_ENST00000295095.6_Nonsense_Mutation_p.R112*			Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15	112	PH.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity	p.R112R(1)		endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		TCTTTCTAGTCGAAGAATTGA	0.303000													11	287					0	0	1	0	0
NBPF9	400818	broad.mit.edu	37	1	144825409	144825409	+	Missense_Mutation	SNP	G	G	A	rs558823		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:144825409G>A	ENST00000440491.2	+	11	1361	c.1361G>A	c.(1360-1362)gGt>gAt	p.G454D	NBPF9_ENST00000338347.4_Intron|NBPF9_ENST00000468645.1_3'UTR|NBPF9_ENST00000281815.8_Intron	NM_001037675.2	NP_001032764.1			neuroblastoma breakpoint family, member 9											NS(2)|prostate(1)	3						GACTCACTGGGTAGATGGTAT	0.493000													6	775					0	0	1	0	0
AC008103.5	0	broad.mit.edu	37	22	18844766	18844766	+	RNA	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr22:18844766G>A	ENST00000412938.1	+	0	3016																											CAGCCTCTGAGGGCAGCAGTG	0.557000													6	28					0	0	1	0	0
MATN3	4148	broad.mit.edu	37	2	20205753	20205753	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:20205753C>T	ENST00000407540.3	-	2	604	c.542G>A	c.(541-543)cGa>cAa	p.R181Q	MATN3_ENST00000421259.2_Missense_Mutation_p.R181Q	NM_002381.4	NP_002372.1	O15232	MATN3_HUMAN	matrilin 3	181	VWFA.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGAGGGCTCTCGAGCCCCTGC	0.592000													5	150					0	0	1	0	0
PYROXD2	84795	broad.mit.edu	37	10	100152219	100152219	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr10:100152219C>T	ENST00000370575.4	-	10	1080	c.1032G>A	c.(1030-1032)ccG>ccA	p.P344P	PYROXD2_ENST00000483923.1_5'UTR	NM_032709.2	NP_116098.2	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 2	344							oxidoreductase activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	12						AGGTGATCTGCGGTGATGTGT	0.537000													48	240					0	0	1	0	0
OSBPL7	114881	broad.mit.edu	37	17	45891044	45891044	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr17:45891044G>A	ENST00000007414.3	-	15	1699	c.1508C>T	c.(1507-1509)cCg>cTg	p.P503L	OSBPL7_ENST00000392507.3_Missense_Mutation_p.P503L	NM_145798.2	NP_665741.1	Q9BZF2	OSBL7_HUMAN	oxysterol binding protein-like 7	503					lipid transport		lipid binding			autonomic_ganglia(1)|endometrium(6)|kidney(2)|large_intestine(5)|liver(2)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32						AGTGTTGAGCGGCTCGTTGAG	0.637000													25	233					0	0	1	0	0
DEFB126	81623	broad.mit.edu	37	20	126290	126290	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr20:126290C>T	ENST00000382398.3	+	2	553	c.293C>T	c.(292-294)tCg>tTg	p.S98L	DEFB126_ENST00000542572.1_3'UTR	NM_030931.2	NP_112193.1	Q9BYW3	DB126_HUMAN	defensin, beta 126	98					defense response to bacterium	extracellular region				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)	4		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			ACTACTGCTTCGATGTCTTCG	0.458000													43	801					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10916473	10916473	+	Missense_Mutation	SNP	C	C	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr21:10916473C>A	ENST00000298232.7	-	19	1486	c.1119G>T	c.(1117-1119)aaG>aaT	p.K373N	TPTE_ENST00000361285.4_Missense_Mutation_p.K391N|TPTE_ENST00000342420.5_Missense_Mutation_p.K353N|TPTE_ENST00000415664.2_Intron	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	391	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAACATATCTCTTCTGAAAAG	0.338000													5	281					0.184627	0.184627	1	1	0
ROBO2	6092	broad.mit.edu	37	3	77614262	77614262	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:77614262C>T	ENST00000461745.1	+	12	2740	c.1840C>T	c.(1840-1842)Cgc>Tgc	p.R614C	ROBO2_ENST00000487694.3_Missense_Mutation_p.R630C|ROBO2_ENST00000332191.8_Missense_Mutation_p.R614C	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	614					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AGATCCTGTGCGCACACAAGG	0.468000													6	372					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186672819	186672819	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:186672819G>A	ENST00000343098.5	+	17	19053	c.19053G>A	c.(19051-19053)aaG>aaA	p.K6351K	FSIP2_ENST00000424728.1_Silent_p.K6262K	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						GTGTTTTAAAGCACTCTGGCT	0.338000													112	146					0	0	1	0	0
IL1RN	3557	broad.mit.edu	37	2	113888640	113888640	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:113888640C>T	ENST00000361779.3	+	5	467	c.122C>T	c.(121-123)cCc>cTc	p.P41L	IL1RN_ENST00000409930.3_Missense_Mutation_p.P75L|IL1RN_ENST00000409052.1_Missense_Mutation_p.P41L|IL1RN_ENST00000259206.5_Missense_Mutation_p.P78L|IL1RN_ENST00000354115.2_Missense_Mutation_p.P57L	NM_173843.2	NP_776215.1	P18510	IL1RA_HUMAN	interleukin 1 receptor antagonist	75					immune response|inflammatory response|response to glucocorticoid stimulus	centrosome|extracellular space|nucleus|plasma membrane	cytokine activity|interleukin-1 receptor antagonist activity			breast(1)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	10					Anakinra(DB00026)	GATGTGGTACCCATTGAGCCT	0.483000									Lichen Sclerosis et Atrophicus, Familial Clustering of				51	235					0	0	1	0	0
IGHV3-43	0	broad.mit.edu	37	14	106926482	106926482	+	RNA	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr14:106926482T>C	ENST00000434710.1	-	0	139																											CCAGCTGCACTTCACACTGGA	0.527000													7	701					0	0	1	0	0
PRSS3P2	0	broad.mit.edu	37	7	142482229	142482229	+	RNA	SNP	T	T	A	rs145494190	by1000genomes	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:142482229T>A	ENST00000603901.1	+	0	609					NR_001296.3													p.P203P(1)									CTGGTGGCCCTGTGGTCTGCA	0.493000													5	201					0	0	1	0	0
CCDC74B	91409	broad.mit.edu	37	2	130897154	130897154	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:130897154G>A	ENST00000392984.3	-	7	2166	c.1423C>T	c.(1423-1425)Cgg>Tgg	p.R475W	CCDC74B_ENST00000409943.3_Missense_Mutation_p.R307W|CCDC74B_ENST00000310463.6_Missense_Mutation_p.R373W			Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	373										endometrium(2)|large_intestine(1)|lung(3)	6	Colorectal(110;0.1)					TGCAGGCGCCGTTTCTGCATT	0.602000													5	122					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21730847	21730847	+	Missense_Mutation	SNP	G	G	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr17:21730847G>T	ENST00000584755.1	+	2	546	c.149G>T	c.(148-150)cGg>cTg	p.R50L	UBBP4_ENST00000583708.1_Intron|UBBP4_ENST00000578713.1_Missense_Mutation_p.R50L|UBBP4_ENST00000584398.1_Intron																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GGCAAGCAGCGGGAAGATGGC	0.522000													4	164					0.014758	0.014918	1	1	0
AC006293.3	0	broad.mit.edu	37	19	55221559	55221559	+	RNA	SNP	G	G	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:55221559G>T	ENST00000413439.1	+	0	1339																											ACGGGGGCCAGTACAGATGCT	0.672000													6	187					1.49906e-05	1.56187e-05	1	1	0
RPL32P3	0	broad.mit.edu	37	3	129116038	129116038	+	RNA	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:129116038C>T	ENST00000514355.1	-	0	412																				lung(1)	1						GAGGCTTTCCCGCCCAGGGAC	0.567000													8	382					0	0	1	0	0
SPG7	6687	broad.mit.edu	37	16	89579447	89579447	+	Splice_Site	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr16:89579447T>C	ENST00000268704.2	+	3	391		c.e3+2		SPG7_ENST00000341316.2_Splice_Site	NM_003119.2	NP_003110.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)						cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		AGGACGAAGGTATATTCATCT	0.423000													30	3					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179413171	179413171	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:179413171C>T	ENST00000589042.1	-	339	93406	c.93182G>A	c.(93181-93183)cGt>cAt	p.R31061H	TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R22121H|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R22188H|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R29420H|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R28493H|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R21996H|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29420	Ig-like 139.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGCCAACTACGGCGACTTGC	0.498000													23	824					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													6	481					0	0	1	0	0
MCM6	4175	broad.mit.edu	37	2	136605704	136605704	+	Missense_Mutation	SNP	G	G	A	rs142938887		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:136605704G>A	ENST00000264156.2	-	14	2032	c.1972C>T	c.(1972-1974)Cgt>Tgt	p.R658C	MCM6_ENST00000492091.1_5'UTR	NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	658					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	GTTTCCACACGGATGATTGAT	0.393000													165	151					0	0	1	0	0
RRM1	6240	broad.mit.edu	37	11	4142834	4142834	+	Splice_Site	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:4142834C>T	ENST00000300738.5	+	10	1081	c.876_splice	c.e10-1	p.R293_splice	RRM1_ENST00000528470.1_3'UTR|RRM1_ENST00000534285.1_Splice_Site_p.R71_splice|RRM1_ENST00000537197.1_5'UTR|RRM1_ENST00000423050.2_Splice_Site_p.R196_splice	NM_001033.3	NP_001024.1	P23921	RIR1_HUMAN	ribonucleotide reductase M1	293					deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)	14		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)	TTACCACTAGCGTCCTGGGGC	0.373000													19	210					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132516562	132516562	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:132516562G>A	ENST00000333577.4	+	31	6036	c.5927G>A	c.(5926-5928)cGt>cAt	p.R1976H	EP400_ENST00000330386.6_Missense_Mutation_p.R1859H|EP400_ENST00000389562.2_Missense_Mutation_p.R1939H|EP400_ENST00000332482.4_Missense_Mutation_p.R1903H|EP400_ENST00000389561.2_Missense_Mutation_p.R1940H			Q96L91	EP400_HUMAN	E1A binding protein p400	1976	Helicase C-terminal.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		ACTCACAGCCGTACCACAGGT	0.463000													7	874					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63447722	63447722	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr14:63447722G>A	ENST00000322893.7	-	6	1078	c.810C>T	c.(808-810)ttC>ttT	p.F270F	KCNH5_ENST00000394968.1_Silent_p.F212F|KCNH5_ENST00000394964.2_Silent_p.F212F|KCNH5_ENST00000420622.2_Silent_p.F270F	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	270					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CGGGCCCCACGAAAGTCGTGT	0.433000													9	287					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82408791	82408791	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:82408791G>A	ENST00000370728.1	+	8	1181	c.536G>A	c.(535-537)cGt>cAt	p.R179H	LPHN2_ENST00000319517.6_Missense_Mutation_p.R179H|LPHN2_ENST00000370721.1_Missense_Mutation_p.R183H|LPHN2_ENST00000370717.2_Missense_Mutation_p.R179H|LPHN2_ENST00000370715.1_Missense_Mutation_p.R179H|LPHN2_ENST00000370730.1_Missense_Mutation_p.R179H|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370725.1_Missense_Mutation_p.R179H|LPHN2_ENST00000370713.1_Missense_Mutation_p.R179H|LPHN2_ENST00000370727.1_Missense_Mutation_p.R179H|LPHN2_ENST00000335786.5_Missense_Mutation_p.R179H|LPHN2_ENST00000394879.1_Missense_Mutation_p.R179H|LPHN2_ENST00000359929.3_Missense_Mutation_p.R179H|LPHN2_ENST00000370723.1_Missense_Mutation_p.R179H|LPHN2_ENST00000271029.4_Missense_Mutation_p.R179H			O95490	LPHN2_HUMAN	latrophilin 2	179	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ACTCCCTATCGTACCGATACT	0.393000													69	219					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13700762	13700762	+	Silent	SNP	A	A	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:13700762A>G	ENST00000265104.4	-	78	13814	c.13710T>C	c.(13708-13710)taT>taC	p.Y4570Y		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4570					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGTTTTCTGCATAAATCCTTA	0.378000									Kartagener syndrome				6	594					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108394663	108394663	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:108394663G>A	ENST00000361582.3	+	25	2954	c.2724G>A	c.(2722-2724)gcG>gcA	p.A908A	DZIP3_ENST00000463306.1_Silent_p.A908A	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	908					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						TAAAGGCTGCGGTAGACAGTT	0.363000													4	203					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167625947	167625947	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:167625947C>T	ENST00000519204.1	+	15	2745	c.2627C>T	c.(2626-2628)cCg>cTg	p.P876L	TENM2_ENST00000545108.1_Missense_Mutation_p.P997L|TENM2_ENST00000403607.2_Missense_Mutation_p.P821L|TENM2_ENST00000518659.1_Missense_Mutation_p.P997L|TENM2_ENST00000520394.1_Missense_Mutation_p.P765L					teneurin transmembrane protein 2																		GTGTGGCTGCCGTGGAACAGC	0.572000													9	286					0	0	1	0	0
KRTAP9-9	81870	broad.mit.edu	37	17	39411940	39411940	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr17:39411940C>T	ENST00000394008.1	+	1	305	c.303C>T	c.(301-303)ggC>ggT	p.G101G		NM_030975.2	NP_112237.2	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	101						keratin filament				endometrium(3)|skin(2)|upper_aerodigestive_tract(1)	6		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CCAGCTGTGGCCAGAGCAGCT	0.617000													6	400					0	0	1	0	0
GRB10	2887	broad.mit.edu	37	7	50672033	50672033	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:50672033G>A	ENST00000403097.1	-	15	2193	c.1413C>T	c.(1411-1413)ccC>ccT	p.P471P	GRB10_ENST00000398810.2_Silent_p.P419P|GRB10_ENST00000398812.2_Silent_p.P477P|GRB10_ENST00000402578.1_Silent_p.P419P|GRB10_ENST00000407526.1_Silent_p.P419P|GRB10_ENST00000335866.3_Silent_p.P419P|GRB10_ENST00000401949.1_Silent_p.P477P|GRB10_ENST00000439599.1_Silent_p.P471P|GRB10_ENST00000402497.1_Silent_p.P419P|GRB10_ENST00000406641.1_Silent_p.P419P|GRB10_ENST00000357271.5_Silent_p.P431P			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	477					insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					AAGGGTGGAGGGGACTTTGGC	0.502000									Russell-Silver syndrome				12	789					0	0	1	0	0
MAPT	4137	broad.mit.edu	37	17	44060806	44060806	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr17:44060806G>A	ENST00000344290.5	+	6	958	c.636G>A	c.(634-636)ccG>ccA	p.P212P	MAPT_ENST00000340799.5_Intron|MAPT_ENST00000334239.8_Intron|MAPT_ENST00000262410.5_Silent_p.P212P|MAPT_ENST00000574436.1_Intron|MAPT_ENST00000570299.1_Intron|MAPT_ENST00000535772.1_Intron|MAPT_ENST00000576518.1_Intron|MAPT_ENST00000446361.3_Intron|MAPT_ENST00000431008.3_Intron|MAPT_ENST00000415613.2_Silent_p.P212P|MAPT_ENST00000420682.2_Intron|MAPT_ENST00000571987.1_Silent_p.P212P|MAPT_ENST00000351559.5_Intron|MAPT_ENST00000347967.5_Intron	NM_001123066.3	NP_001116538.2	P10636	TAU_HUMAN	microtubule-associated protein tau	212					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		Melanoma(429;0.216)				AAGAGAGGCCGGGGAGCAAGG	0.692000													5	75					0	0	1	0	0
RNF20	56254	broad.mit.edu	37	9	104312897	104312897	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:104312897C>T	ENST00000389120.3	+	10	1192	c.1102C>T	c.(1102-1104)Cgg>Tgg	p.R368W		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	368					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding	p.R368W(1)		breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		GGTGGAATTGCGGAGTGCAGT	0.468000													7	829					0	0	1	0	0
SYMPK	8189	broad.mit.edu	37	19	46345734	46345734	+	Silent	SNP	C	C	T	rs150307195		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:46345734C>T	ENST00000245934.7	-	9	1105	c.861G>A	c.(859-861)ccG>ccA	p.P287P		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	287					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		TGGCCAGCGTCGGGGGCAGGT	0.557000													6	263					0	0	1	0	0
PDE7A	5150	broad.mit.edu	37	8	66701121	66701121	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr8:66701121G>A	ENST00000379419.4	-	1	198	c.56C>T	c.(55-57)tCt>tTt	p.S19F	PDE7A_ENST00000396642.3_Intron|PDE7A_ENST00000401827.3_Intron	NM_002603.3	NP_002594.1	Q13946	PDE7A_HUMAN	phosphodiesterase 7A	45						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			large_intestine(5)|lung(3)|stomach(1)|urinary_tract(1)	10			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	GCCTACCTTAGAGGTGATCCA	0.393000													10	438					0	0	1	0	0
OR2A4	79541	broad.mit.edu	37	6	132022505	132022505	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:132022505G>A	ENST00000315453.2	-	1	130	c.37C>T	c.(37-39)Cta>Tta	p.L13L	ENPP3_ENST00000358229.5_Intron|ENPP3_ENST00000414305.1_Intron|ENPP3_ENST00000357639.3_Intron	NM_030908.1	NP_112170.1	O95047	OR2A4_HUMAN	olfactory receptor, family 2, subfamily A, member 4	13					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.018)|OV - Ovarian serous cystadenocarcinoma(155;0.041)		AATCCCAGTAGGAGGAACTCT	0.468000													16	264					0	0	1	0	0
CCNT1	904	broad.mit.edu	37	12	49087818	49087818	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:49087818G>A	ENST00000261900.3	-	9	1401	c.1179C>T	c.(1177-1179)cgC>cgT	p.R393R		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	393					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						CATGCTTCGCGCGGTATTCTT	0.443000													25	937					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107869450	107869450	+	Silent	SNP	T	T	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chrX:107869450T>C	ENST00000328300.6	+	36	3361	c.3117T>C	c.(3115-3117)ggT>ggC	p.G1039G	COL4A5_ENST00000361603.2_Silent_p.G1039G	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1039	Triple-helical region.		G -> S (in APSX; juvenile type).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						GGCCTCAGGGTGTGGAAGGGC	0.418000									Alport syndrome with Diffuse Leiomyomatosis				9	191					0	0	1	0	0
CMIP	80790	broad.mit.edu	37	16	81641270	81641270	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr16:81641270G>A	ENST00000537098.3	+	2	471	c.399G>A	c.(397-399)acG>acA	p.T133T	CMIP_ENST00000539778.2_Silent_p.T39T	NM_198390.2	NP_938204.2	Q8IY22	CMIP_HUMAN	c-Maf inducing protein	99						cytoplasm|nucleus				endometrium(5)|kidney(1)|lung(7)	13						TACAGCTCACGATTCCTGGGG	0.493000													4	160					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103276725	103276725	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:103276725G>A	ENST00000424685.2	-	18	2419	c.2260C>T	c.(2260-2262)Cgg>Tgg	p.R754W	RELN_ENST00000428762.1_Missense_Mutation_p.R754W|RELN_ENST00000343529.5_Missense_Mutation_p.R754W			P78509	RELN_HUMAN	reelin	754					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGCTGACGCCGCCCATCTTTG	0.443000													6	299					0	0	1	0	0
ATP2A1	487	broad.mit.edu	37	16	28914723	28914723	+	Missense_Mutation	SNP	A	A	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr16:28914723A>C	ENST00000395503.4	+	21	3126	c.2942A>C	c.(2941-2943)gAc>gCc	p.D981A	ATP2A1_ENST00000357084.3_Missense_Mutation_p.D981A|ATP2A1_ENST00000536376.1_Missense_Mutation_p.D856A	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	981					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						ATTGGGCTCGACGAAATCCTC	0.612000													172	200					0	0	1	0	0
VLDLR	7436	broad.mit.edu	37	9	2644767	2644767	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:2644767G>A	ENST00000382100.2	+	8	1456	c.1100G>A	c.(1099-1101)tGt>tAt	p.C367Y	VLDLR_ENST00000382099.2_Missense_Mutation_p.C367Y	NM_003383.3	NP_003374.3	P98155	VLDLR_HUMAN	very low density lipoprotein receptor	367	EGF-like 1.				cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	24				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		AATGGTGGATGTTCTCATATC	0.363000													54	219					0	0	1	0	0
OR6K3	391114	broad.mit.edu	37	1	158687397	158687397	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:158687397C>T	ENST00000368146.1	-	1	556	c.557G>A	c.(556-558)gGg>gAg	p.G186E	OR6K3_ENST00000368145.1_Missense_Mutation_p.G170E			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					TTGGTTGGGCCCACAGAAAGG	0.517000													18	367					0	0	1	0	0
FERD3L	222894	broad.mit.edu	37	7	19184847	19184847	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:19184847G>A	ENST00000275461.3	-	1	197	c.139C>T	c.(139-141)Cga>Tga	p.R47*	AC003986.5_ENST00000452700.1_RNA	NM_152898.2	NP_690862.1	Q96RJ6	FER3L_HUMAN	Fer3-like bHLH transcription factor	47					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.R47*(1)		breast(1)|endometrium(4)|large_intestine(8)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	35						CTTCCCTCTCGGAGCGCAAGG	0.657000													16	416					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	160964285	160964285	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:160964285C>T	ENST00000283249.2	-	14	2410	c.2173G>A	c.(2173-2175)Gtc>Atc	p.V725I	ITGB6_ENST00000428609.2_Missense_Mutation_p.V683I|ITGB6_ENST00000409967.2_Missense_Mutation_p.V618I|ITGB6_ENST00000409872.1_Missense_Mutation_p.V725I			P18564	ITB6_HUMAN	integrin, beta 6	725					cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						CACAGTAGGACAACCCCGATG	0.428000													26	330					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149485990	149485990	+	RNA	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:149485990C>T	ENST00000378016.2	+	0	4209							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ACGACTGTGGCGATGGCTCTG	0.582000													6	161					0	0	1	0	0
CLSTN1	22883	broad.mit.edu	37	1	9803970	9803970	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:9803970G>A	ENST00000377298.4	-	9	2120	c.1328C>T	c.(1327-1329)cCt>cTt	p.P443L	CLSTN1_ENST00000377288.3_Missense_Mutation_p.P443L|CLSTN1_ENST00000361311.4_Missense_Mutation_p.P433L	NM_001009566.1	NP_001009566.1	O94985	CSTN1_HUMAN	calsyntenin 1	443					homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(9)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	36	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		GAACTCTGCAGGTCTGTATTT	0.507000													137	504					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34526717	34526717	+	Missense_Mutation	SNP	C	C	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr20:34526717C>G	ENST00000374012.3	+	16	2528	c.2399C>G	c.(2398-2400)aCc>aGc	p.T800S	PHF20_ENST00000439301.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	800					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					GTCACTGACACCAGGAGCAAG	0.592000													8	517					0	0	1	0	0
KRTAP5-8	57830	broad.mit.edu	37	11	71249545	71249545	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:71249545C>T	ENST00000398534.3	+	1	475	c.444C>T	c.(442-444)tgC>tgT	p.C148C		NM_021046.2	NP_066384.2	O75690	KRA58_HUMAN	keratin associated protein 5-8	148	9 X 4 AA repeats of C-C-X-P.					extracellular region|keratin filament	structural constituent of epidermis			cervix(1)|endometrium(1)|lung(2)|skin(1)|stomach(1)	6						AGTCCAGCTGCTGTAAGCCCT	0.607000													8	856					0	0	1	0	0
CAMK2B	816	broad.mit.edu	37	7	44259760	44259760	+	Silent	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:44259760G>A	ENST00000395749.2	-	23	1978	c.1902C>T	c.(1900-1902)acC>acT	p.T634T	CAMK2B_ENST00000440254.2_Silent_p.T510T|CAMK2B_ENST00000346990.4_Silent_p.T417T|CAMK2B_ENST00000358707.3_Silent_p.T471T|CAMK2B_ENST00000395747.2_Silent_p.T486T|CAMK2B_ENST00000350811.3_Silent_p.T510T|CAMK2B_ENST00000258682.6_Silent_p.T485T|CAMK2B_ENST00000457475.1_Silent_p.T486T|CAMK2B_ENST00000353625.4_Silent_p.T447T|CAMK2B_ENST00000347193.4_Silent_p.T460T|CAMK2B_ENST00000489429.1_5'UTR|CAMK2B_ENST00000502837.2_3'UTR	NM_001220.4	NP_001211.3	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II beta	634					interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)	18						CAGACTGGCTGGTGCGGGGCC	0.667000													6	144					0	0	1	0	0
SLC26A4	5172	broad.mit.edu	37	7	107350622	107350622	+	Missense_Mutation	SNP	G	G	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:107350622G>T	ENST00000265715.3	+	19	2437	c.2213G>T	c.(2212-2214)gGt>gTt	p.G738V	SLC26A4_ENST00000541474.1_Missense_Mutation_p.G299V|SLC26A4_ENST00000543100.1_Missense_Mutation_p.G307V|SLC26A4_ENST00000544569.1_Missense_Mutation_p.G325V	NM_000441.1	NP_000432.1	O43511	S26A4_HUMAN	solute carrier family 26 (anion exchanger), member 4	738					regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(8)|lung(16)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						TCTCAAGAGGGTCAAGGTTCC	0.358000									Pendred syndrome				5	394					0.000602214	0.000613732	1	1	0
ASTN2	23245	broad.mit.edu	37	9	119976846	119976846	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:119976846C>T	ENST00000313400.4	-	3	906	c.806G>A	c.(805-807)cGt>cAt	p.R269H	ASTN2_ENST00000373996.3_Missense_Mutation_p.R269H|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000361209.2_Missense_Mutation_p.R269H			O75129	ASTN2_HUMAN	astrotactin 2	269						integral to membrane		p.R269H(1)		breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						CCGGGATGAACGGAAGCTCTC	0.602000													90	163					0	0	1	0	0
MASP2	10747	broad.mit.edu	37	1	11106647	11106647	+	Silent	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:11106647C>T	ENST00000400897.3	-	3	393	c.378G>A	c.(376-378)ccG>ccA	p.P126P	MASP2_ENST00000400898.3_Silent_p.P126P	NM_006610.3	NP_006601.2	O00187	MASP2_HUMAN	mannan-binding lectin serine peptidase 2	126	CUB 1.		P -> L (in dbSNP:rs56392418).		complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			biliary_tract(1)|endometrium(2)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		ACCCCGTGAACGGCTTCTCGT	0.602000													6	162					0	0	1	0	0
C10orf91	170393	broad.mit.edu	37	10	134261371	134261371	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr10:134261371C>T	ENST00000392630.3	+	3	305	c.244C>T	c.(244-246)Cgt>Tgt	p.R82C	C10orf91_ENST00000321248.2_Missense_Mutation_p.R82C|C10orf91_ENST00000490765.1_3'UTR	NM_173541.2	NP_775812.1	Q5T1B1	CJ091_HUMAN	chromosome 10 open reading frame 91	82										endometrium(1)|kidney(1)|lung(1)|ovary(2)	5		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;6.95e-05)|Epithelial(32;0.000142)|all cancers(32;0.000162)		GCTTTCTCTGCGTCAGCCCCA	0.637000													41	836					0	0	1	0	0
MAML1	9794	broad.mit.edu	37	5	179193309	179193309	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:179193309C>T	ENST00000292599.3	+	2	1561	c.1298C>T	c.(1297-1299)aCg>aTg	p.T433M	MAML1_ENST00000503050.1_3'UTR	NM_014757.4	NP_055572.1	Q92585	MAML1_HUMAN	mastermind-like 1 (Drosophila)	433					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	36	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGCAGCAGACGGGGCCCTCC	0.607000													100	547					0	0	1	0	0
ARF1	375	broad.mit.edu	37	1	228284870	228284870	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:228284870C>T	ENST00000541182.1	+	2	317	c.55C>T	c.(55-57)Cgc>Tgc	p.R19C	ARF1_ENST00000478424.1_3'UTR|ARF1_ENST00000272102.5_Missense_Mutation_p.R19C|ARF1_ENST00000540651.1_Missense_Mutation_p.R19C	NM_001024227.1|NM_001024228.1	NP_001019398.1|NP_001019399.1	P84077	ARF1_HUMAN	ADP-ribosylation factor 1	19					cellular copper ion homeostasis|COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|protein transport|regulation of defense response to virus by virus|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction|viral reproduction	cytosol|Golgi membrane|perinuclear region of cytoplasm|plasma membrane	GTP binding|GTPase activity|protein binding|receptor signaling protein activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)	10		Prostate(94;0.0405)				AAAAGAAATGCGCATCCTCAT	0.542000													5	451					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109690583	109690583	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:109690583G>A	ENST00000277225.5	+	3	4679	c.4390G>A	c.(4390-4392)Gcc>Acc	p.A1464T	ZNF462_ENST00000457913.1_Missense_Mutation_p.A1464T|ZNF462_ENST00000441147.2_Missense_Mutation_p.A309T			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1464					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						AGCCAACCCCGCCATATCCTC	0.527000													5	164					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72209576	72209576	+	RNA	SNP	C	C	G	rs147711959	by1000genomes	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:72209576C>G	ENST00000438125.1	-	0	579							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										CTCGGAGCATCGACTATGACA	0.413000													5	390					0	0	1	0	0
LZIC	84328	broad.mit.edu	37	1	9990460	9990460	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:9990460delT	ENST00000377223.1	-	8	817	c.570delA	c.(568-570)aafs	p.K190fs	LZIC_ENST00000541052.1_Frame_Shift_Del_p.K211fs|LZIC_ENST00000400903.2_Frame_Shift_Del_p.K190fs|LZIC_ENST00000377213.1_Frame_Shift_Del_p.K190fs			Q8WZA0	LZIC_HUMAN	leucine zipper and CTNNBIP1 domain containing	190							beta-catenin binding			breast(1)|endometrium(2)|large_intestine(2)|lung(1)|skin(1)	7		all_lung(284;0.000407)|Renal(390;0.000469)|Lung NSC(185;0.000577)|Colorectal(325;0.0062)|Breast(348;0.00686)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.29e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;0.000242)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|STAD - Stomach adenocarcinoma(132;0.00842)|READ - Rectum adenocarcinoma(331;0.0419)		CACCATGTCATTTTTTTGTTT	0.333													7	1427	---	---	---	---					
CROCCP2	0	broad.mit.edu	37	1	16953827	16953828	+	RNA	INS	-	-	C	rs57007114		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:16953827_16953828insC	ENST00000412962.1	-	0	477																											TCACTTTCCTGCCCGAACCTCC	0.609													8	115	---	---	---	---					
ESPNP	0	broad.mit.edu	37	1	17034125	17034126	+	RNA	INS	-	-	AGCT	rs141324796	by1000genomes	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:17034125_17034126insAGCT	ENST00000492551.1	-	0	477_478					NR_026567.1																						CAGCAGCAGCCAGCTGAGCACC	0.718													8	34	---	---	---	---					
RP1-125I3.2	0	broad.mit.edu	37	1	26186960	26186960	+	RNA	DEL	T	T	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:26186960delT	ENST00000455431.1	+	0	263																											AATTTTGTAATTTTTTTTTTT	0.552													7	22	---	---	---	---					
RP11-782C8.2	0	broad.mit.edu	37	1	143210193	143210194	+	RNA	INS	-	-	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:143210193_143210194insT	ENST00000412204.2	-	0	876_877				RP11-782C8.1_ENST00000438000.1_lincRNA																							GGCAGCATTTGTTTTTTTAACA	0.317													26	471	---	---	---	---					
BCL9	607	broad.mit.edu	37	1	147091501	147091501	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:147091501delC	ENST00000234739.3	+	8	2280	c.1540delC	c.(1540-1542)ccfs	p.P517fs		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	517	Poly-Pro.|Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					GGTCCGAGGACCCCCCCCTCC	0.582			T	"""IGH@, IGL@"""	B-ALL								11	614	---	---	---	---					
NBPF20	100288142	broad.mit.edu	37	1	148262260	148262260	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:148262260delG	ENST00000369202.1	-	98	12353	c.12156delC	c.(12154-12156)ccfs	p.P4052fs						neuroblastoma breakpoint family, member 20											breast(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|urinary_tract(1)	27						AAAGTCACCTGGGGCATGGTG	0.443													7	2144	---	---	---	---					
RP5-998N21.4	0	broad.mit.edu	37	1	149377834	149377839	+	RNA	DEL	TCTTTG	TCTTTG	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:149377834_149377839delTCTTTG	ENST00000415338.1	-	0	1061																											GTATCTCTTCTCTTTGTCTTTTTCTG	0.461													11	17	---	---	---	---					
UBAP2L	9898	broad.mit.edu	37	1	154224030	154224036	+	Frame_Shift_Del	DEL	AGTTTGG	AGTTTGG	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:154224030_154224036delAGTTTGG	ENST00000428931.1	+	14	1732_1738	c.1565_1571delAGTTTGG	c.(1564-1572)cgfs	p.QFG522fs	UBAP2L_ENST00000361546.2_Frame_Shift_Del_p.QFG522fs|UBAP2L_ENST00000343815.6_Frame_Shift_Del_p.QFG522fs|UBAP2L_ENST00000271877.7_Frame_Shift_Del_p.QFG533fs	NM_014847.3	NP_055662.3	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like	522					binding of sperm to zona pellucida		protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|prostate(1)|urinary_tract(2)	50	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGGGCATTGCAGTTTGGGTCAGAGCCT	0.531													29	769	---	---	---	---					
CADM3	57863	broad.mit.edu	37	1	159163298	159163299	+	Frame_Shift_Ins	INS	-	-	AGCA			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:159163298_159163299insAGCA	ENST00000368125.4	+	4	625_626	c.468_469insAGCA	c.(466-471)gggcaafs	p.Q157fs	CADM3_ENST00000368124.4_Frame_Shift_Ins_p.Q191fs	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	157	Ig-like C2-type 1.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					AGTCTTCTGGGAGCAAGCCTGC	0.520													7	291	---	---	---	---					
RYR2	6262	broad.mit.edu	37	1	237969494	237969494	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr1:237969494delT	ENST00000366574.2	+	99	14526	c.14209delT	c.(14209-14211)ttfs	p.F4739fs	RYR2_ENST00000542537.1_Frame_Shift_Del_p.F4723fs|RYR2_ENST00000360064.6_Frame_Shift_Del_p.F4745fs	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4739					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTATAACAACTTTTTTTTTGC	0.403													7	250	---	---	---	---					
SLC3A1	6519	broad.mit.edu	37	2	44502859	44502860	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:44502859_44502860insC	ENST00000260649.6	+	1	261_262	c.185_186insC	c.(184-186)gcafs	p.A62fs	SLC3A1_ENST00000410056.3_Frame_Shift_Ins_p.A62fs|SLC3A1_ENST00000409229.3_Frame_Shift_Ins_p.A62fs|SLC3A1_ENST00000409741.1_Frame_Shift_Ins_p.A62fs|SLC3A1_ENST00000409387.1_Frame_Shift_Ins_p.A62fs	NM_000341.3	NP_000332.2	Q07837	SLC31_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 1	62					carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(1)|skin(3)	26		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	TTCAAGGGCGTCCAGCCCTATG	0.614													23	125	---	---	---	---					
SLC9A4	389015	broad.mit.edu	37	2	103149137	103149137	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:103149137delA	ENST00000295269.4	+	12	2844	c.2387delA	c.(2386-2388)cafs	p.Q796fs		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	796					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						CCTTTGCTCCAAAAAAAATAG	0.473													9	168	---	---	---	---					
GCC2	9648	broad.mit.edu	37	2	109087883	109087884	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:109087883_109087884insA	ENST00000309863.6	+	6	2812_2813	c.2098_2099insA	c.(2098-2100)aaafs	p.K700fs		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	700					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						ACTCAGTTCAGAAAAAAAACAG	0.307													9	1170	---	---	---	---					
TNS1	7145	broad.mit.edu	37	2	218712887	218712889	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr2:218712887_218712889delGCT	ENST00000171887.4	-	17	2428_2430	c.1976_1978delAGC	c.(1975-1980)cct>c	p.QP659del	TNS1_ENST00000430930.1_In_Frame_Del_p.QP659del|TNS1_ENST00000419504.1_In_Frame_Del_p.QP659del	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	659	Gln-rich.					cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GGTGGGCGAGgctgctgctgctg	0.660													7	80	---	---	---	---					
EDEM1	9695	broad.mit.edu	37	3	5248941	5248941	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:5248941delT	ENST00000256497.4	+	7	1454	c.1321delT	c.(1321-1323)ttfs	p.F442fs	EDEM1_ENST00000445686.1_Frame_Shift_Del_p.F247fs	NM_014674.2	NP_055489.1	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like 1	442					ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		TCTGCAGGCCTTTTTCCCTGG	0.463													7	492	---	---	---	---					
LNP1	348801	broad.mit.edu	37	3	100148586	100148588	+	In_Frame_Del	DEL	GAT	GAT	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:100148586_100148588delGAT	ENST00000383693.3	+	2	1293_1295	c.13_15delGAT	c.(13-15)del	p.D10del	LNP1_ENST00000489752.1_In_Frame_Del_p.D10del	NM_001085451.1	NP_001078920.1	A1A4G5	LNP1_HUMAN	leukemia NUP98 fusion partner 1	10	Poly-Asp.									cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	6						GGAGCACAAAGATGATGATGATG	0.507													8	942	---	---	---	---					
TFG	10342	broad.mit.edu	37	3	100455439	100455441	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:100455439_100455441delAGA	ENST00000240851.4	+	6	940_942	c.600_602delAGA	c.(598-603)gca>gc	p.AE200del	TFG_ENST00000490574.1_In_Frame_Del_p.AE200del|TFG_ENST00000476228.1_In_Frame_Del_p.AE200del|TFG_ENST00000418917.2_In_Frame_Del_p.AE200del	NM_001195478.1|NM_001195479.1|NM_006070.5	NP_001182407.1|NP_001182408.1|NP_006061.2	Q92734	TFG_HUMAN	TRK-fused gene	200					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/NR4A3(2)|TFG/NTRK1_ENST00000392302(5)|TFG/ALK(9)	large_intestine(4)|lung(2)|prostate(1)|stomach(1)	8						GTGCTCCTGCAGAAGATCGTTCA	0.512			T	"""NTRK1, ALK"""	"""papillary thyroid, ALCL, NSCLC"""								28	250	---	---	---	---					
EIF4G1	1981	broad.mit.edu	37	3	184039744	184039746	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr3:184039744_184039746delGAA	ENST00000342981.4	+	9	1786_1788	c.1372_1374delGAA	c.(1372-1374)del	p.E465del	EIF4G1_ENST00000427845.1_In_Frame_Del_p.E378del|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000414031.1_In_Frame_Del_p.E425del|EIF4G1_ENST00000346169.2_In_Frame_Del_p.E465del|EIF4G1_ENST00000392537.2_In_Frame_Del_p.E378del|EIF4G1_ENST00000435046.2_In_Frame_Del_p.E269del|EIF4G1_ENST00000434061.2_In_Frame_Del_p.E269del|EIF4G1_ENST00000350481.5_In_Frame_Del_p.E301del|EIF4G1_ENST00000424196.1_In_Frame_Del_p.E472del|EIF4G1_ENST00000411531.1_In_Frame_Del_p.E425del|EIF4G1_ENST00000382330.3_In_Frame_Del_p.E472del|EIF4G1_ENST00000352767.3_In_Frame_Del_p.E472del|EIF4G1_ENST00000441154.1_In_Frame_Del_p.E301del|EIF4G1_ENST00000319274.6_In_Frame_Del_p.E465del	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	465	Poly-Glu.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGAGGAAATGgaagaagaagaag	0.562													7	347	---	---	---	---					
CRIPAK	285464	broad.mit.edu	37	4	1389361	1389362	+	Frame_Shift_Del	DEL	CA	CA	-	rs71299249		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:1389361_1389362delCA	ENST00000324803.4	+	1	4022_4023	c.1062_1063delCA	c.(1060-1065)ctcafs	p.LT354fs		NM_175918.3	NP_787114.2	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	354					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CCCGCCTGCTCACACGTGCCCA	0.653													8	2078	---	---	---	---					
UGDH	7358	broad.mit.edu	37	4	39515752	39515753	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:39515752_39515753insA	ENST00000316423.6	-	3	556_557	c.214_215insT	c.(214-216)tacfs	p.Y72fs	UGDH_ENST00000506179.1_Frame_Shift_Ins_p.Y72fs|UGDH_ENST00000507089.1_5'UTR|UGDH_ENST00000515398.1_5'UTR|UGDH_ENST00000501493.2_Frame_Shift_Ins_p.Y72fs	NM_001184701.1|NM_003359.3	NP_001171630.1|NP_003350.1	O60701	UGDH_HUMAN	UDP-glucose 6-dehydrogenase	72					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity	p.S72fs*18(1)		breast(1)|central_nervous_system(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(2)	27					NADH(DB00157)	AATATTGGTAGAAAAAAAAAGA	0.297													16	813	---	---	---	---					
PCDH10	57575	broad.mit.edu	37	4	134073569	134073571	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:134073569_134073571delCTG	ENST00000264360.4	+	1	3100_3102	c.2274_2276delCTG	c.(2272-2277)ctc>ct	p.LC758del		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	758	Cys-rich.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ATTGCTGCCTCTGCTGCTGCTGC	0.581													9	238	---	---	---	---					
FAM198B	51313	broad.mit.edu	37	4	159091487	159091489	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:159091487_159091489delGCT	ENST00000393807.5	-	3	1327_1329	c.921_923delAGC	c.(919-924)gcg>gc	p.AA307del	FAM198B_ENST00000585682.1_Intron|FAM198B_ENST00000296530.8_Intron|FAM198B_ENST00000592057.1_3'UTR|FAM198B_ENST00000589306.1_Intron	NM_001031700.2	NP_001026870.2	Q6UWH4	F198B_HUMAN	family with sequence similarity 198, member B	307						Golgi membrane|integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(14)|skin(2)|urinary_tract(1)	26						GGAAAGACACGCTGCTGCTGCTG	0.458													7	339	---	---	---	---					
UFSP2	55325	broad.mit.edu	37	4	186336369	186336370	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:186336369_186336370insT	ENST00000264689.6	-	6	739_740	c.623_624insA	c.(622-624)actfs	p.T208fs		NM_018359.3	NP_060829.2	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	208						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		TTGTTACAAGATTTTTTTTCCC	0.342													110	215	---	---	---	---					
FRG1	2483	broad.mit.edu	37	4	190882978	190882980	+	Splice_Site	DEL	AAG	AAG	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr4:190882978_190882980delAAG	ENST00000226798.4	+	8	853_855	c.629_splice	c.e8-1	p.K212_splice		NM_004477.2	NP_004468.1	Q14331	FRG1_HUMAN	FSHD region gene 1	212					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus				NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		TCTTTACAGAAAGAAATTTCAGA	0.276													7	912	---	---	---	---					
SRFBP1	153443	broad.mit.edu	37	5	121356129	121356130	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:121356129_121356130insA	ENST00000339397.4	+	6	771_772	c.699_700insA	c.(697-702)acaaaafs	p.TK233fs		NM_152546.2	NP_689759.2	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|skin(1)	15		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)		TAAGTCAAACCAAAAAAAACAA	0.401													10	561	---	---	---	---					
TIMD4	91937	broad.mit.edu	37	5	156378745	156378747	+	In_Frame_Del	DEL	TTG	TTG	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:156378745_156378747delTTG	ENST00000274532.2	-	3	511_513	c.455_457delCAA	c.(454-459)agc>a	p.TS152del	TIMD4_ENST00000407087.3_In_Frame_Del_p.TS152del	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	152	Thr-rich.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGGTGGGGCTTGTTGTTGTTGT	0.537													11	1419	---	---	---	---					
HMMR	3161	broad.mit.edu	37	5	162917425	162917426	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr5:162917425_162917426insA	ENST00000416990.2	+	17	2144_2145	c.1647_1648insA	c.(1645-1650)gcaaaafs	p.AK549fs	RP11-80G7.1_ENST00000514724.2_RNA|HMMR_ENST00000393915.4_Frame_Shift_Ins_p.AK664fs|HMMR_ENST00000358715.3_Frame_Shift_Ins_p.AK663fs|RP11-80G7.1_ENST00000521666.1_RNA|HMMR_ENST00000353866.3_Frame_Shift_Ins_p.AK648fs|HMMR_ENST00000432118.2_Frame_Shift_Ins_p.AK577fs			O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor (RHAMM)	663						cell surface|cytoplasm	hyaluronic acid binding			cervix(1)|kidney(3)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	23	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		GTCAGCTTGCTAAAAAAAAACA	0.307													8	566	---	---	---	---					
RRP36	88745	broad.mit.edu	37	6	42989434	42989451	+	In_Frame_Del	DEL	CGGGGCCCGACGTCCCCG	CGGGGCCCGACGTCCCCG	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:42989434_42989451delCGGGGCCCGACGTCCCCG	ENST00000244496.5	+	1	52_69	c.42_59delCGGGGCCCGACGTCCCCG	c.(40-60)gcc>gc	p.AGARRPR14del		NM_033112.2	NP_149103.1	Q96EU6	RRP36_HUMAN	ribosomal RNA processing 36 homolog (S. cerevisiae)	14					ribosomal small subunit biogenesis|rRNA processing	nucleolus				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(5)|lung(1)|ovary(1)|prostate(1)	11						gggccggggccggggcccgacgtccccgcggggcccgg	0.784													7	13	---	---	---	---					
PHIP	55023	broad.mit.edu	37	6	79655961	79655961	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:79655961delT	ENST00000275034.4	-	38	4554	c.4387delA	c.(4387-4389)ggfs	p.R1463fs	PHIP_ENST00000479165.1_5'UTR	NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1463					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		TTTAAGATCCTTTTTTTCCTT	0.358													7	707	---	---	---	---					
GABRR2	2570	broad.mit.edu	37	6	89975427	89975429	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:89975427_89975429delAAG	ENST00000402938.3	-	7	925_927	c.792_794delCTT	c.(790-795)ttg>tt	p.FL264del	GABRR2_ENST00000602399.1_In_Frame_Del_p.FL289del			P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 2	289					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(10)|prostate(2)|urinary_tract(1)	21		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		TGTTTGGAGCAAGAAGAAGAAGA	0.517													8	294	---	---	---	---					
MAP3K5	4217	broad.mit.edu	37	6	136888858	136888859	+	Frame_Shift_Ins	INS	-	-	CTCA	rs139070587		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr6:136888858_136888859insCTCA	ENST00000359015.4	-	26	4031_4032	c.3671_3672insTGAG	c.(3670-3672)aacfs	p.N1224fs	MAP3K5_ENST00000355845.4_Frame_Shift_Ins_p.N471fs	NM_005923.3	NP_005914.1	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5	1224					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		AACTGAGCGTGCTCACGCCTGA	0.475													66	105	---	---	---	---					
CARD11	84433	broad.mit.edu	37	7	2963941	2963943	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:2963941_2963943delGGA	ENST00000396946.4	-	15	2267_2269	c.1864_1866delTCC	c.(1864-1866)del	p.S622del		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	622					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CGGATTGGTGGGAGGAGGAGGAG	0.616			Mis		DLBCL								7	448	---	---	---	---					
HOXA1	3198	broad.mit.edu	37	7	27135314	27135316	+	In_Frame_Del	DEL	CGA	CGA	-	rs10951154	byFrequency	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:27135314_27135316delCGA	ENST00000343060.4	-	1	277_279	c.216_218delTCG	c.(214-219)cac>ca	p.HR72del	HOTAIRM1_ENST00000495032.1_RNA|HOXA1_ENST00000355633.5_In_Frame_Del_p.HR72del	NM_005522.4	NP_005513.1	P49639	HXA1_HUMAN	homeobox A1	72	Poly-His.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						Ctgggggtggcgatggtggtggt	0.650											OREG0003750	type=REGULATORY REGION|Gene=BC031342|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	11	373	---	---	---	---					
OGDH	4967	broad.mit.edu	37	7	44684936	44684936	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:44684936delT	ENST00000222673.5	+	3	275	c.233delT	c.(232-234)atfs	p.I78fs	OGDH_ENST00000449767.1_Frame_Shift_Del_p.I78fs|OGDH_ENST00000447398.1_Frame_Shift_Del_p.I78fs|OGDH_ENST00000444676.1_Frame_Shift_Del_p.I78fs|OGDH_ENST00000439616.2_Intron|OGDH_ENST00000543843.1_Frame_Shift_Del_p.I18fs|OGDH_ENST00000443864.2_Frame_Shift_Del_p.I78fs	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	78					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding	p.R81fs*19(1)		breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	TCATGGGACATTTTTTTTCGC	0.577													12	856	---	---	---	---					
CCT6P3	0	broad.mit.edu	37	7	64528813	64528814	+	RNA	INS	-	-	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:64528813_64528814insT	ENST00000426828.1	+	0	621					NR_033416.1																						CTTTCTGTAACTTTTTTTTTTT	0.317													7	92	---	---	---	---					
DTX2	113878	broad.mit.edu	37	7	76112249	76112249	+	Frame_Shift_Del	DEL	A	A	-	rs147779783	byFrequency	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:76112249delA	ENST00000324432.5	+	5	1203	c.693delA	c.(691-693)ccfs	p.P231fs	DTX2_ENST00000413936.2_Frame_Shift_Del_p.P231fs|DTX2_ENST00000446820.2_Frame_Shift_Del_p.P231fs|DTX2_ENST00000307569.8_Frame_Shift_Del_p.P231fs|DTX2_ENST00000446600.1_Frame_Shift_Del_p.P140fs|DTX2_ENST00000430490.2_Frame_Shift_Del_p.P231fs	NM_020892.2	NP_065943.2	Q86UW9	DTX2_HUMAN	deltex homolog 2 (Drosophila)	231					Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(1)|skin(1)|stomach(2)	27						AGCACCCCCCACACAGGACCG	0.657													8	1745	---	---	---	---					
DPY19L2P2	0	broad.mit.edu	37	7	102878163	102878164	+	RNA	INS	-	-	TAAAATAAAA	rs59775517		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:102878163_102878164insTAAAATAAAA	ENST00000312132.4	-	0	2866																											accccagaacttaaaataaaaa	0.351													8	53	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149518533	149518533	+	RNA	DEL	C	C	-	rs11353848		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr7:149518533delC	ENST00000378016.2	+	0	12602							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GAGGAGCAGTCCCAGAGCCAG	0.711													13	14	---	---	---	---					
NPM2	10361	broad.mit.edu	37	8	21892020	21892021	+	Splice_Site	INS	-	-	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr8:21892020_21892021insA	ENST00000397940.1	+	7	1546_1547		c.e7-1		NPM2_ENST00000521157.1_Splice_Site|NPM2_ENST00000518119.1_Splice_Site|NPM2_ENST00000381530.5_Splice_Site|NPM2_ENST00000289820.6_Splice_Site			Q86SE8	NPM2_HUMAN	nucleophosmin/nucleoplasmin 2						chromatin remodeling|embryo development|oocyte differentiation|positive regulation of meiosis|regulation of exit from mitosis|single fertilization	cytoplasmic chromatin|nuclear chromatin	histone binding|nucleic acid binding			large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	4				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)		TTGGTTCCCAGAAAAAAAAGCT	0.406													7	938	---	---	---	---					
CNTNAP3B	728577	broad.mit.edu	37	9	43844265	43844265	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:43844265delG	ENST00000377564.3	+	10	1992	c.1599delG	c.(1597-1599)gcfs	p.A533fs		NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	533	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						AGCAGGGGGCGCTGGGGAGTT	0.542													7	72	---	---	---	---					
C9orf43	257169	broad.mit.edu	37	9	116187646	116187648	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr9:116187646_116187648delGCA	ENST00000288462.4	+	10	1334_1336	c.888_890delGCA	c.(886-891)cgg>cg	p.RQ296del	C9orf43_ENST00000374165.1_In_Frame_Del_p.RQ296del	NM_152786.1	NP_689999.1	Q8TAL5	CI043_HUMAN	chromosome 9 open reading frame 43	296	Gln-rich.									breast(2)|large_intestine(6)|lung(2)|ovary(1)|pancreas(1)|prostate(3)	15						agcagcagcggcagcagcagcag	0.557													7	326	---	---	---	---					
RUFY2	55680	broad.mit.edu	37	10	70156583	70156583	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr10:70156583delT	ENST00000388768.2	-	4	783	c.457delA	c.(457-459)tgfs	p.M153fs	RUFY2_ENST00000472394.2_5'UTR|RUFY2_ENST00000399200.2_Intron|RUFY2_ENST00000454950.2_Frame_Shift_Del_p.M60fs|RUFY2_ENST00000602465.1_Frame_Shift_Del_p.M118fs|RUFY2_ENST00000342616.4_Frame_Shift_Del_p.M118fs	NM_017987.4	NP_060457.4	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain containing 2	167	RUN.					nucleus	metal ion binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(2)	20						TAATCGGCCATTTTTTTTTGC	0.398													7	240	---	---	---	---					
ZMIZ1	57178	broad.mit.edu	37	10	81070787	81070789	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr10:81070787_81070789delCTC	ENST00000334512.5	+	24	3514_3516	c.2942_2944delCTC	c.(2941-2946)gct>g	p.AP981del	ZMIZ1_ENST00000446377.2_Intron	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	981	Pro-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CACAGTGGGGCTCCTCCTCCTCC	0.635													9	746	---	---	---	---					
SCD	6319	broad.mit.edu	37	10	102107836	102107838	+	In_Frame_Del	DEL	ACC	ACC	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr10:102107836_102107838delACC	ENST00000370355.2	+	2	424_426	c.43_45delACC	c.(43-45)del	p.T19del		NM_005063.4	NP_005054.3	O00767	ACOD_HUMAN	stearoyl-CoA desaturase (delta-9-desaturase)	19					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			endometrium(1)|large_intestine(3)|lung(5)	9		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		TAGCTCCTATACCACCACCACCA	0.581													9	889	---	---	---	---					
TRIM51HP	0	broad.mit.edu	37	11	55065032	55065032	+	RNA	DEL	T	T	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:55065032delT	ENST00000526016.1	-	0	393					NR_038174.2																						AAAGACTGCATTTTTTTTTAG	0.398													11	217	---	---	---	---					
RTN3	10313	broad.mit.edu	37	11	63525788	63525788	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr11:63525788delT	ENST00000354497.4	+	4	634	c.570delT	c.(568-570)gcfs	p.A190fs	RTN3_ENST00000537981.1_3'UTR|RTN3_ENST00000339997.4_3'UTR|RTN3_ENST00000540798.1_3'UTR|RTN3_ENST00000341307.2_3'UTR|RTN3_ENST00000356000.3_3'UTR|RTN3_ENST00000377819.5_3'UTR	NM_001265591.1	NP_001252520.1	O95197	RTN3_HUMAN	reticulon 3	0					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	20						CATTCCAAGCTTTTTTTTTAA	0.348													7	205	---	---	---	---					
STRAP	11171	broad.mit.edu	37	12	16047015	16047015	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:16047015delA	ENST00000419869.2	+	5	751	c.438delA	c.(436-438)atfs	p.I146fs	STRAP_ENST00000538352.1_Frame_Shift_Del_p.I52fs|STRAP_ENST00000025399.6_Frame_Shift_Del_p.I159fs	NM_007178.3	NP_009109.3	Q9Y3F4	STRAP_HUMAN	serine/threonine kinase receptor associated protein	146					mRNA processing|RNA splicing	cell junction|mitochondrion|spliceosomal complex	identical protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(6)|skin(1)	15		Hepatocellular(102;0.121)				CTTCTGGTATAAAAAAAGCTC	0.294													7	804	---	---	---	---					
SMARCC2	6601	broad.mit.edu	37	12	56559127	56559128	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:56559127_56559128insG	ENST00000394023.3	-	27	3311_3312	c.3206_3207insC	c.(3205-3207)cggfs	p.R1069fs	RP11-977G19.5_ENST00000553176.1_RNA|SMARCC2_ENST00000550164.1_Frame_Shift_Ins_p.R1069fs|SMARCC2_ENST00000267064.4_Frame_Shift_Ins_p.R1038fs|SMARCC2_ENST00000347471.4_Frame_Shift_Ins_p.R1069fs	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	1038	Pro-rich.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GGGGAACCCCTGGTGGGACTGC	0.584													9	319	---	---	---	---					
R3HDM2	22864	broad.mit.edu	37	12	57674205	57674207	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:57674205_57674207delTGC	ENST00000402412.1	-	14	1668_1670	c.1278_1280delGCA	c.(1276-1281)caa>ca	p.QQ426del	R3HDM2_ENST00000393811.2_In_Frame_Del_p.QQ139del|R3HDM2_ENST00000413953.2_In_Frame_Del_p.QQ139del|R3HDM2_ENST00000441731.2_In_Frame_Del_p.QQ73del|R3HDM2_ENST00000347140.3_In_Frame_Del_p.QQ412del|RP11-123K3.4_ENST00000548184.1_RNA|R3HDM2_ENST00000403821.2_In_Frame_Del_p.QQ412del|R3HDM2_ENST00000358907.2_In_Frame_Del_p.QQ412del			Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	412	Gln-rich.					nucleus	nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	22						AGCAGGAAGTtgctgctgctgct	0.576													11	393	---	---	---	---					
TMEM19	55266	broad.mit.edu	37	12	72094757	72094757	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr12:72094757delT	ENST00000266673.5	+	6	1587	c.993delT	c.(991-993)ggfs	p.G331fs		NM_018279.3	NP_060749.2	Q96HH6	TMM19_HUMAN	transmembrane protein 19	331						integral to membrane				large_intestine(1)|lung(8)	9		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CTGCTTGGGGTTTTTGGCCCA	0.433													8	1062	---	---	---	---					
SACS	26278	broad.mit.edu	37	13	23912863	23912864	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr13:23912863_23912864insT	ENST00000382298.3	-	10	5739_5740	c.5151_5152insA	c.(5149-5154)aacctgfs	p.NL1717fs	SACS_ENST00000402364.1_Frame_Shift_Ins_p.NL967fs|SACS_ENST00000382292.3_Frame_Shift_Ins_p.NL1717fs	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1717					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GAAGAGCAGGATTTTTTTTTAA	0.361													7	250	---	---	---	---					
RBM26	64062	broad.mit.edu	37	13	79918806	79918807	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr13:79918806_79918807insT	ENST00000438737.2	-	15	2621_2622	c.2181_2182insA	c.(2179-2184)aaaggafs	p.G728fs	RBM26_ENST00000438724.1_Frame_Shift_Ins_p.G704fs|RBM26_ENST00000267229.7_Frame_Shift_Ins_p.G701fs			Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	728					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GTACTTACCTGTTTTTTTTTCT	0.332													11	187	---	---	---	---					
TRAV9-2	0	broad.mit.edu	37	14	22409533	22409539	+	RNA	DEL	CTCTCTC	CTCTCTC	-	rs57759840		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr14:22409533_22409539delCTCTCTC	ENST00000390441.2	+	0	102																											ctctctctctctctctctTTTTTTTTT	0.415													9	34	---	---	---	---					
IRF9	10379	broad.mit.edu	37	14	24633132	24633134	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr14:24633132_24633134delAGC	ENST00000396864.3	+	5	828_830	c.541_543delAGC	c.(541-543)del	p.S187del	RP11-468E2.4_ENST00000558468.1_3'UTR|IRF9_ENST00000557894.1_In_Frame_Del_p.S85del	NM_006084.4	NP_006075.3	Q00978	IRF9_HUMAN	interferon regulatory factor 9	187	Poly-Ser.				interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	16				GBM - Glioblastoma multiforme(265;0.00853)		AGACATTGGGagcagcagcagca	0.567													8	309	---	---	---	---					
SIPA1L1	26037	broad.mit.edu	37	14	72190482	72190484	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr14:72190482_72190484delTCC	ENST00000555818.1	+	16	4738_4740	c.4390_4392delTCC	c.(4390-4392)del	p.S1468del	SIPA1L1_ENST00000358550.2_In_Frame_Del_p.S1447del|SIPA1L1_ENST00000554874.1_3'UTR|SIPA1L1_ENST00000537413.1_In_Frame_Del_p.S922del|SIPA1L1_ENST00000381232.3_In_Frame_Del_p.S1447del	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1468	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ctcctcctcttcctcctcctcct	0.552													8	712	---	---	---	---					
SYNE3	161176	broad.mit.edu	37	14	95921888	95921890	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr14:95921888_95921890delCTC	ENST00000334258.5	-	5	975_977	c.961_963delGAG	c.(961-963)del	p.E321del	SYNE3_ENST00000553340.1_In_Frame_Del_p.E321del|SYNE3_ENST00000554873.1_In_Frame_Del_p.E78del|SYNE3_ENST00000557275.1_In_Frame_Del_p.E321del	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						CCCGCAGCCGCTCCTCCTCCTCC	0.616													10	635	---	---	---	---					
IGHV4-31	0	broad.mit.edu	37	14	106805656	106805656	+	RNA	DEL	G	G	-	rs112628447		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr14:106805656delG	ENST00000438142.2	-	0	60																											TTCTTGCACAGGAGGTCCAGG	0.502													7	236	---	---	---	---					
UBN1	29855	broad.mit.edu	37	16	4910691	4910693	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr16:4910691_4910693delAGA	ENST00000396658.4	+	6	1401_1403	c.698_700delAGA	c.(697-702)gag>g	p.EK233del	UBN1_ENST00000590769.1_In_Frame_Del_p.EK233del|UBN1_ENST00000262376.6_In_Frame_Del_p.EK233del|UBN1_ENST00000545171.1_In_Frame_Del_p.EK233del	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	233	Lys-rich.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity	p.K234E(1)		NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						GCCAGTAAGGAGAAGAAGAAGAA	0.453													14	1246	---	---	---	---					
NPIPA1	9284	broad.mit.edu	37	16	15045758	15045759	+	Frame_Shift_Ins	INS	-	-	GT			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr16:15045758_15045759insGT	ENST00000328085.6	+	8	929_930	c.929_930insGT	c.(928-930)gtgfs	p.V310fs	NPIPA1_ENST00000472413.1_3'UTR	NM_006985.2	NP_008916.2			nuclear pore complex interacting protein family, member A1																		ACACCTCCCGAGTGTCTGCTCA	0.559													7	620	---	---	---	---					
TNRC6A	27327	broad.mit.edu	37	16	24807240	24807240	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr16:24807240delA	ENST00000395799.3	+	9	3670	c.3541delA	c.(3541-3543)aafs	p.K1182fs	TNRC6A_ENST00000315183.7_Frame_Shift_Del_p.K1182fs	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1182	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		TCTGAGTGGCAAAAAAAGGAG	0.398													11	1012	---	---	---	---					
ZFHX3	463	broad.mit.edu	37	16	72821594	72821596	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr16:72821594_72821596delGCC	ENST00000268489.5	-	10	11251_11253	c.10579_10581delGGC	c.(10579-10581)del	p.G3527del	AC004943.1_ENST00000584072.1_RNA|ZFHX3_ENST00000397992.5_In_Frame_Del_p.G2613del	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3527	Poly-Gly.		G -> GGG.		muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				AGTGGTACGAgccgccgccgccg	0.690													13	418	---	---	---	---					
TRPV2	51393	broad.mit.edu	37	17	16335490	16335492	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr17:16335490_16335492delTGC	ENST00000338560.7	+	12	2264_2266	c.1865_1867delTGC	c.(1864-1869)gtg>g	p.VL622del	TRPV2_ENST00000577397.1_In_Frame_Del_p.VL192del|TRPV2_ENST00000583241.1_3'UTR	NM_016113.4	NP_057197.2	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel, subfamily V, member 2	622					sensory perception	integral to plasma membrane|melanosome	calcium channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|stomach(3)	28				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CGCGGCATGGTGCTGCTGCTGCT	0.596													10	285	---	---	---	---					
HOXB2	3212	broad.mit.edu	37	17	46622130	46622132	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr17:46622130_46622132delAGG	ENST00000330070.4	-	1	1309_1311	c.142_144delCCT	c.(142-144)del	p.P48del	HOXB-AS1_ENST00000435312.1_RNA|HOXB-AS1_ENST00000504972.3_RNA	NM_002145.3	NP_002136.1	P14652	HXB2_HUMAN	homeobox B2	48					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	11						TTTGCTCGAAAGGAGGAGGAGGA	0.596													7	357	---	---	---	---					
COIL	8161	broad.mit.edu	37	17	55028016	55028016	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr17:55028016delT	ENST00000240316.4	-	2	621	c.587delA	c.(586-588)agfs	p.K196fs		NM_004645.2	NP_004636.1	P38432	COIL_HUMAN	coilin	196	Lys-rich (basic).					Cajal body|nucleolus	protein C-terminus binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	15	Breast(9;6.15e-08)					ATTCTTAGCCTTTTTTTTATA	0.393													10	616	---	---	---	---					
RNF43	54894	broad.mit.edu	37	17	56492756	56492757	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr17:56492756_56492757delCA	ENST00000584437.1	-	1	2137_2138	c.182_183delTG	c.(181-183)cfs	p.L61fs	RNF43_ENST00000583753.1_Frame_Shift_Del_p.L61fs|BZRAP1-AS1_ENST00000583841.1_RNA|RNF43_ENST00000577716.1_Frame_Shift_Del_p.L61fs|RNF43_ENST00000581868.1_Intron|RNF43_ENST00000500597.2_Frame_Shift_Del_p.L61fs|RNF43_ENST00000407977.2_Frame_Shift_Del_p.L61fs			Q68DV7	RNF43_HUMAN	ring finger protein 43	61						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AAGTGAGATTCAGTTTTCCTGT	0.426													308	29	---	---	---	---					
TRAPPC8	22878	broad.mit.edu	37	18	29453417	29453418	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr18:29453417_29453418insA	ENST00000283351.4	-	14	2372_2373	c.2037_2038insT	c.(2035-2040)ttgccafs	p.LP679fs	TRAPPC8_ENST00000582539.1_Frame_Shift_Ins_p.LP625fs	NM_014939.3	NP_055754.2	Q9Y2L5	TPPC8_HUMAN	trafficking protein particle complex 8	679					ER to Golgi vesicle-mediated transport	cis-Golgi network				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(7)|liver(2)|lung(13)|ovary(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CTGTCATGGCCAAAAAAAACCC	0.356													7	176	---	---	---	---					
HMHA1	23526	broad.mit.edu	37	19	1073174	1073175	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:1073174_1073175insC	ENST00000313093.2	+	3	679_680	c.448_449insC	c.(448-450)ccafs	p.P150fs	HMHA1_ENST00000539243.2_Frame_Shift_Ins_p.P166fs|HMHA1_ENST00000536472.1_5'UTR|HMHA1_ENST00000590214.1_Frame_Shift_Ins_p.P177fs|HMHA1_ENST00000592335.1_Frame_Shift_Ins_p.H31fs|HMHA1_ENST00000543365.1_Frame_Shift_Ins_p.P33fs|HMHA1_ENST00000586866.1_Frame_Shift_Ins_p.P154fs	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	150					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGCCCGCGGGCCCACGAGTGC	0.658													8	443	---	---	---	---					
LILRB2	0	broad.mit.edu	37	19	54780707	54780709	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr19:54780707_54780709delGAG	ENST00000391748.1	-	10	1559_1561	c.1432_1434delCTC	c.(1432-1434)del	p.L478del	LILRB2_ENST00000434421.1_In_Frame_Del_p.L363del|LILRB2_ENST00000391746.1_In_Frame_Del_p.L479del|LILRB2_ENST00000391749.4_In_Frame_Del_p.L479del|LILRB2_ENST00000314446.5_In_Frame_Del_p.L478del	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	479					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity	p.L479L(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ggatgaggaagaggaggaggagg	0.611													7	451	---	---	---	---					
CSRP2BP	57325	broad.mit.edu	37	20	18142695	18142695	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr20:18142695delA	ENST00000278816.2	+	6	1564	c.914delA	c.(913-915)gafs	p.E305fs	CSRP2BP_ENST00000489634.2_Frame_Shift_Del_p.E177fs|CSRP2BP_ENST00000435364.2_Frame_Shift_Del_p.E305fs|CSRP2BP_ENST00000377681.2_Frame_Shift_Del_p.E304fs			Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	305					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|stomach(1)	34						GTGATTCTGGAAAAAGGCGAA	0.537													9	1144	---	---	---	---					
ADNP	23394	broad.mit.edu	37	20	49508203	49508204	+	Frame_Shift_Ins	INS	-	-	T	rs6096163		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr20:49508203_49508204insT	ENST00000396029.3	-	5	3614_3615	c.3047_3048insA	c.(3046-3048)agcfs	p.S1016fs	ADNP_ENST00000396032.3_Frame_Shift_Ins_p.S1016fs|ADNP_ENST00000349014.3_Frame_Shift_Ins_p.S1016fs|ADNP_ENST00000371602.4_Frame_Shift_Ins_p.S1016fs	NM_015339.2	NP_056154.1	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector homeobox	1016						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(7)|kidney(1)|large_intestine(13)|lung(7)|ovary(2)|prostate(2)|skin(2)	39						GCATGGTAGCCTTTTTTTTGGC	0.460													13	792	---	---	---	---					
SCAF4	57466	broad.mit.edu	37	21	33044257	33044259	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr21:33044257_33044259delGCT	ENST00000286835.7	-	20	3279_3281	c.2897_2899delAGC	c.(2896-2901)cca>c	p.QP966del	SCAF4_ENST00000399804.1_In_Frame_Del_p.QP944del|SCAF4_ENST00000434667.3_In_Frame_Del_p.QP951del	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	966	Poly-Gln.					nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						GATGGTGgtggctgctgctgctg	0.581													16	432	---	---	---	---					
PTTG1IP	754	broad.mit.edu	37	21	46276194	46276196	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr21:46276194_46276196delGCA	ENST00000330938.3	-	4	581_583	c.361_363delTGC	c.(361-363)del	p.C121del	PTTG1IP_ENST00000445724.2_Intron|PTTG1IP_ENST00000397887.3_Intron|PTTG1IP_ENST00000494690.1_5'UTR|PTTG1IP_ENST00000397886.3_In_Frame_Del_p.C100del	NM_004339.3	NP_004330.1	P53801	PTTG_HUMAN	pituitary tumor-transforming 1 interacting protein	121	Poly-Cys.				protein import into nucleus	cytoplasm|integral to membrane|nucleus				ovary(1)|prostate(1)	2				Colorectal(79;0.0659)		TCTTCCTCCTGCAGCAGCAGCAG	0.616													10	279	---	---	---	---					
EIF4ENIF1	56478	broad.mit.edu	37	22	31884692	31884693	+	Frame_Shift_Ins	INS	-	-	TCTCCTA	rs148554829	by1000genomes	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr22:31884692_31884693insTCTCCTA	ENST00000397525.1	-	2	235_236	c.12_13insTAGGAGA	c.(10-15)aggtatfs	p.RY4fs	EIF4ENIF1_ENST00000330125.5_Frame_Shift_Ins_p.RY4fs|EIF4ENIF1_ENST00000397523.1_Frame_Shift_Ins_p.RY4fs|EIF4ENIF1_ENST00000344710.5_Frame_Shift_Ins_p.RY4fs	NM_001164501.1	NP_001157973.1	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E nuclear import factor 1	4						nucleus	protein binding|protein transporter activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TCACCCATACTTCTCCTATCCA	0.455													52	213	---	---	---	---					
BIK	638	broad.mit.edu	37	22	43525245	43525247	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chr22:43525245_43525247delGCT	ENST00000216115.2	+	5	480_482	c.417_419delGCT	c.(415-420)gcg>gc	p.AL139del		NM_001197.4	NP_001188.1	Q13323	BIK_HUMAN	BCL2-interacting killer (apoptosis-inducing)	139	Leucine-zipper (Potential).				apoptosis|induction of apoptosis|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	endomembrane system|integral to membrane				breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|urinary_tract(1)	5		Ovarian(80;0.0694)				tgctgctggcgctgctgctgctg	0.724													7	354	---	---	---	---					
NUDT11	0	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	TCCTCGAGGCAGCC	-	rs78182391		TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	ENST00000375992.3	-	0	139_152					NM_018159.3	NP_060629.2	Q96G61	NUD11_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.?(5)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	9	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.692										HNSCC(48;0.14)			10	33	---	---	---	---					
ARMCX3	51566	broad.mit.edu	37	X	100880152	100880154	+	In_Frame_Del	DEL	TGA	TGA	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chrX:100880152_100880154delTGA	ENST00000341189.4	+	5	1049_1051	c.183_185delTGA	c.(181-186)tct>tc	p.SD61del	ARMCX3_ENST00000537169.1_In_Frame_Del_p.SD61del|ARMCX3_ENST00000471229.2_In_Frame_Del_p.SD61del	NM_016607.3	NP_057691.1	Q9UH62	ARMX3_HUMAN	armadillo repeat containing, X-linked 3	61						integral to membrane	binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11						ATGACTGGTCTGATGATGATGAT	0.517													8	557	---	---	---	---					
MAGEC1	9947	broad.mit.edu	37	X	140994639	140994641	+	In_Frame_Del	DEL	CTC	CTC	-	rs144357389	byFrequency	TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chrX:140994639_140994641delCTC	ENST00000285879.4	+	4	1735_1737	c.1449_1451delCTC	c.(1447-1452)agc>ag	p.SS487del	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	487							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCTGTGAGCTCCTCCTCCTCC	0.473										HNSCC(15;0.026)			9	765	---	---	---	---					
MAMLD1	10046	broad.mit.edu	37	X	149639325	149639327	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chrX:149639325_149639327delCAG	ENST00000370401.2	+	4	1790_1792	c.1480_1482delCAG	c.(1480-1482)del	p.Q502del	MAMLD1_ENST00000426613.2_In_Frame_Del_p.Q477del|MAMLD1_ENST00000262858.5_In_Frame_Del_p.Q502del|MAMLD1_ENST00000432680.2_In_Frame_Del_p.Q477del|MAMLD1_ENST00000455522.2_5'UTR			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	502	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.Q469Q(1)|p.Q494Q(1)|p.Q421Q(1)		breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCcagcaacagcagcagcagc	0.532													10	159	---	---	---	---					
MAMLD1	10046	broad.mit.edu	37	X	149639633	149639635	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chrX:149639633_149639635delGCA	ENST00000370401.2	+	4	2098_2100	c.1788_1790delGCA	c.(1786-1791)ctg>ct	p.LQ596del	MAMLD1_ENST00000426613.2_In_Frame_Del_p.LQ571del|MAMLD1_ENST00000262858.5_In_Frame_Del_p.LQ596del|MAMLD1_ENST00000432680.2_In_Frame_Del_p.LQ571del|MAMLD1_ENST00000455522.2_In_Frame_Del_p.LQ77del			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	596	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					CCTTgcagctgcagcagcagcag	0.611													9	226	---	---	---	---					
PASD1	139135	broad.mit.edu	37	X	150817142	150817144	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chrX:150817142_150817144delGCT	ENST00000370357.4	+	9	930_932	c.685_687delGCT	c.(685-687)del	p.A236del		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	236	Poly-Ala.					nucleus	signal transducer activity	p.A229A(2)		breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CGTTGAACCCgctgctgctgctg	0.433													7	379	---	---	---	---					
PLXNA3	55558	broad.mit.edu	37	X	153688564	153688565	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chrX:153688564_153688565insG	ENST00000369682.3	+	2	216_217	c.41_42insG	c.(40-42)gggfs	p.G14fs		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	14					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity	p.A17fs*39(1)		breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTCCTTGCCGTGGGGGGGGCCC	0.683													7	268	---	---	---	---					
RNA5-8SP6	0	broad.mit.edu	37	Y	10037863	10037863	+	RNA	DEL	C	C	-			TCGA-FB-AAPP-01A-12D-A40W-08	TCGA-FB-AAPP-11A-11D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d00f80a5-fa4b-4d37-a76b-42a7154ad590	beda0a75-c66e-4fd5-a31b-fe48334234e1	g.chrY:10037863delC	ENST00000515896.1	+	0	100																											ATCGACACTTCGAACGCACTT	0.552													7	39	---	---	---	---