Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CPNE2	221184	broad.mit.edu	37	16	57155597	57155597	+	Silent	SNP	G	G	A			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr16:57155597G>A	ENST00000535318.2	+	10	1153	c.792G>A	c.(790-792)gaG>gaA	p.E264E	CPNE2_ENST00000565874.1_Silent_p.E264E|CPNE2_ENST00000290776.8_Silent_p.E264E|CPNE2_ENST00000537605.1_Silent_p.E162E			Q96FN4	CPNE2_HUMAN	copine II	264										central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(5)	21		all_neural(199;0.224)				TGGAGTTCGAGTGCATCAACC	0.527000													21	125					0	0	1	0	0
DTNB	1838	broad.mit.edu	37	2	25705699	25705699	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr2:25705699G>A	ENST00000406818.3	-	10	1294	c.1045C>T	c.(1045-1047)Cac>Tac	p.H349Y	DTNB_ENST00000407661.3_Missense_Mutation_p.H349Y|DTNB_ENST00000407038.3_Missense_Mutation_p.H349Y|DTNB_ENST00000496972.2_Missense_Mutation_p.H292Y|DTNB_ENST00000407186.1_Missense_Mutation_p.H349Y|DTNB_ENST00000288642.8_Missense_Mutation_p.H349Y|DTNB_ENST00000405222.1_Missense_Mutation_p.H349Y|DTNB_ENST00000404103.3_Missense_Mutation_p.H349Y|DTNB_ENST00000545439.1_Missense_Mutation_p.H145Y	NM_001256303.1|NM_021907.4	NP_001243232.1|NP_068707.1	O60941	DTNB_HUMAN	dystrobrevin, beta	349						cytoplasm	calcium ion binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAGGACATGTGGCTAACCATG	0.483000													3	59					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811099	140811099	+	Splice_Site	SNP	C	C	T			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr4:140811099C>T	ENST00000398940.1	-	1	107	c.108_splice	c.e1+1	p.Q36_splice	MAML3_ENST00000327122.5_Silent_p.Q341Q|MAML3_ENST00000509479.2_Silent_p.Q497Q			Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	497					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity	p.Q497Q(2)		breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.542000													5	27					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000328354.6_Silent_p.S372S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	63					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79175617	79175617	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr14:79175617G>A	ENST00000554719.1	+	4	651	c.160G>A	c.(160-162)Gac>Aac	p.D54N	NRXN3_ENST00000335750.5_Missense_Mutation_p.D54N|RP11-232C2.2_ENST00000555680.1_RNA	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	0					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CCGGATTGCGGACACCAAGAT	0.463000													5	92					0	0	1	0	0
TBX2	6909	broad.mit.edu	37	17	59477559	59477559	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr17:59477559G>C	ENST00000240328.3	+	1	303	c.22G>C	c.(22-24)Gcc>Ccc	p.A8P	RP11-332H18.5_ENST00000585765.1_RNA|RP11-332H18.4_ENST00000592009.1_RNA	NM_005994.3	NP_005985.3	Q13207	TBX2_HUMAN	T-box 2	8					cell aging|positive regulation of cell proliferation		sequence-specific DNA binding			endometrium(1)|lung(7)|ovary(1)	9						GGCGCTGGCGGCCAGCGCCAT	0.796000													6	29					0	0	1	0	0
TMEM53	79639	broad.mit.edu	37	1	45120685	45120685	+	Missense_Mutation	SNP	A	A	T			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr1:45120685A>T	ENST00000372237.3	-	3	543	c.380T>A	c.(379-381)cTg>cAg	p.L127Q	TMEM53_ENST00000372243.3_Intron|TMEM53_ENST00000476724.1_5'UTR|TMEM53_ENST00000372235.3_Missense_Mutation_p.L97Q|TMEM53_ENST00000372244.3_Intron|TMEM53_ENST00000372242.3_Missense_Mutation_p.L127Q	NM_024587.2	NP_078863.2	Q6P2H8	TMM53_HUMAN	transmembrane protein 53	127						integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(3)|ovary(2)|urinary_tract(1)	10	Acute lymphoblastic leukemia(166;0.155)					ACGGGTCTGCAGGAGCTCCAG	0.612000											OREG0013446	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	59					0	0	1	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39262083	39262083	+	Missense_Mutation	SNP	A	A	C	rs75392608		TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr17:39262083A>C	ENST00000391415.1	+	1	500	c.443A>C	c.(442-444)aAc>aCc	p.N148T		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	148	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament				central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						tgccagcccaactgctgccgc	0.667000													4	17					0	0	1	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10220329	10220329	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr19:10220329G>A	ENST00000428358.1	+	6	708	c.536G>A	c.(535-537)cGc>cAc	p.R179H	PPAN_ENST00000393793.1_Missense_Mutation_p.R126H|PPAN_ENST00000253107.7_Missense_Mutation_p.R179H|PPAN-P2RY11_ENST00000393796.4_Missense_Mutation_p.R179H|PPAN_ENST00000556468.1_Missense_Mutation_p.R179H	NM_001040664.2|NM_001198690.1	NP_001035754.1|NP_001185619.1	Q9NQ55	SSF1_HUMAN		179	Brix.				RNA splicing	nucleolus	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	31			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			ACCATCAAGCGCTGCCTCCTC	0.597000													5	328					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103040356	103040356	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr2:103040356G>T	ENST00000264260.2	+	4	745	c.156G>T	c.(154-156)caG>caT	p.Q52H	IL18RAP_ENST00000409369.1_Intron	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	52					cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						CAGAGCCACAGAAATCACATT	0.408000													7	53					5.18039e-06	5.56892e-06	1	1	0
EFCAB6	64800	broad.mit.edu	37	22	44083357	44083357	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr22:44083357C>T	ENST00000262726.7	-	11	1389	c.1136G>A	c.(1135-1137)aGa>aAa	p.R379K	EFCAB6_ENST00000358439.4_Intron|EFCAB6_ENST00000396231.2_Missense_Mutation_p.R227K	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	379					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				ATACCTATTTCTTTTTGTCAG	0.308000													13	42					0	0	1	0	0
NAALADL1	10004	broad.mit.edu	37	11	64822094	64822094	+	Silent	SNP	G	G	T			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr11:64822094G>T	ENST00000358658.3	-	5	747	c.720C>A	c.(718-720)ccC>ccA	p.P240P	NAALADL1_ENST00000355369.2_Silent_p.P240P|NAALADL1_ENST00000339885.2_Silent_p.P240P|NAALADL1_ENST00000355721.3_Silent_p.P199P|NAALADL1_ENST00000340252.4_Silent_p.P240P|NAALADL1_ENST00000356632.3_Silent_p.P240P	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	240					proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						CTCCTGAGGGGGGCAGGTACC	0.612000											OREG0032001	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	3	13					0.004672	0.004672	1	1	0
DNAJC5G	285126	broad.mit.edu	37	2	27500634	27500634	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr2:27500634G>T	ENST00000296097.3	+	4	544	c.126G>T	c.(124-126)ttG>ttT	p.L42F	DNAJC5G_ENST00000404433.1_Intron|DNAJC5G_ENST00000406962.1_Intron|DNAJC5G_ENST00000402462.1_Missense_Mutation_p.L42F	NM_173650.1	NP_775921.1	Q8N7S2	DNJ5G_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5 gamma	42	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding			cervix(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATTCCGCATTGCTTCCCCACC	0.488000													26	106					6.04164e-23	6.8366e-23	1	1	0
MEF2A	4205	broad.mit.edu	37	15	100211551	100211551	+	Missense_Mutation	SNP	T	T	A	rs1135555		TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr15:100211551T>A	ENST00000338042.6	+	4	601	c.282T>A	c.(280-282)aaT>aaA	p.N94K	MEF2A_ENST00000449277.2_Missense_Mutation_p.N26K|MEF2A_ENST00000558812.1_Missense_Mutation_p.N26K|MEF2A_ENST00000557942.1_Missense_Mutation_p.N94K|MEF2A_ENST00000354410.5_Intron|MEF2A_ENST00000557785.1_Missense_Mutation_p.N94K|MEF2A_ENST00000453228.2_Missense_Mutation_p.N94K			Q02078	MEF2A_HUMAN	myocyte enhancer factor 2A	94					apoptosis|BMK cascade|cardiac conduction|cellular response to calcium ion|dendrite morphogenesis|innate immune response|mitochondrial genome maintenance|mitochondrion distribution|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|ventricular cardiac myofibril development	nuclear chromatin|nucleoplasm	activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|protein heterodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|SMAD binding			endometrium(2)|large_intestine(2)|lung(7)|ovary(1)	12	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00085)			AAGGCCTTAATGGTTGTGAGA	0.353000													32	122					0	0	1	0	0
FRK	2444	broad.mit.edu	37	6	116265543	116265543	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr6:116265543G>A	ENST00000606080.1	-	6	1450	c.1004C>T	c.(1003-1005)gCg>gTg	p.A335V	FRK_ENST00000538210.1_Missense_Mutation_p.A193V	NM_002031.2	NP_002022.1	P42685	FRK_HUMAN	fyn-related kinase	335	Protein kinase.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|skin(1)|urinary_tract(1)	27		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		AACCTGTGCCGCCATGTCTAC	0.418000													4	81					0	0	1	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13910696	13910696	+	Missense_Mutation	SNP	C	C	G			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr19:13910696C>G	ENST00000254323.2	+	2	505	c.316C>G	c.(316-318)Ctg>Gtg	p.L106V		NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	106							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			CGGGCTGCACCTGCTCCAGAG	0.642000													5	52					0	0	1	0	0
GOLGA8IP	283796	broad.mit.edu	37	15	23261044	23261044	+	Missense_Mutation	SNP	A	A	C			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr15:23261044A>C	ENST00000450802.3	+	10	817	c.719A>C	c.(718-720)gAa>gCa	p.E240A																								GAAAGACATGAATATGCTGAA	0.507000													4	143					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21329485	21329485	+	Missense_Mutation	SNP	G	G	A	rs150204820	by1000genomes	TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr18:21329485G>A	ENST00000313654.9	+	4	900	c.659G>A	c.(658-660)cGt>cAt	p.R220H	LAMA3_ENST00000399516.3_Missense_Mutation_p.R220H	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	220	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity	p.R220H(1)		NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAATATTCCCGTATTGTACCT	0.393000													7	37					0	0	1	0	0
CDK19	23097	broad.mit.edu	37	6	110942543	110942543	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr6:110942543G>A	ENST00000368911.3	-	12	1320	c.1141C>T	c.(1141-1143)Cag>Tag	p.Q381*	CDK19_ENST00000323817.3_Nonsense_Mutation_p.Q321*|CDK19_ENST00000413605.2_Nonsense_Mutation_p.Q257*	NM_015076.3	NP_055891.1	Q9BWU1	CDK19_HUMAN	cyclin-dependent kinase 19	381	Gln-rich.						ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)	22						GCTGTGGGCTGCTGATGCTGG	0.542000													15	205					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107432375	107432375	+	Missense_Mutation	SNP	A	A	T			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr7:107432375A>T	ENST00000340010.5	-	4	466	c.282T>A	c.(280-282)ttT>ttA	p.F94L	SLC26A3_ENST00000422236.2_Missense_Mutation_p.F59L	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	94					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						CCAGCAGAGCAAATGCTAAAC	0.443000													7	54					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29625891	29625891	+	Silent	SNP	C	C	G			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr20:29625891C>G	ENST00000278882.3	+	5	515	c.135C>G	c.(133-135)ggC>ggG	p.G45G	FRG1B_ENST00000439954.2_Silent_p.G50G|FRG1B_ENST00000358464.4_Silent_p.G45G																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TGAAATCTGGCTATGGAAAAT	0.343000													4	122					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414379	20414379	+	Silent	SNP	G	G	A			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr9:20414379G>A	ENST00000380338.4	-	5	751	c.465C>T	c.(463-465)agC>agT	p.S155S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S152S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	155	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S155S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.532000			T	MLL	ALL								4	62					0	0	1	0	0
C9orf84	158401	broad.mit.edu	37	9	114484733	114484733	+	Missense_Mutation	SNP	A	A	G			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr9:114484733A>G	ENST00000394779.3	-	11	2022	c.1778T>C	c.(1777-1779)cTc>cCc	p.L593P	C9orf84_ENST00000394777.4_Missense_Mutation_p.L593P|C9orf84_ENST00000374287.3_Missense_Mutation_p.L632P|C9orf84_ENST00000318737.4_Missense_Mutation_p.L632P	NM_001080551.1	NP_001074020.1	Q5VXU9	CI084_HUMAN	chromosome 9 open reading frame 84	632										breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TTCCTTTAAGAGAAACCTTGT	0.348000													20	75					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414295	20414295	+	Silent	SNP	G	G	A	rs62637688		TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr9:20414295G>A	ENST00000380338.4	-	5	835	c.549C>T	c.(547-549)agC>agT	p.S183S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S180S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	183	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.522000			T	MLL	ALL								4	98					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232600987	232600987	+	Missense_Mutation	SNP	C	C	G			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr1:232600987C>G	ENST00000366630.1	-	8	2777	c.2419G>C	c.(2419-2421)Gag>Cag	p.E807Q	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.E807Q			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	807	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TTCAAGTACTCCTGCCTCGTT	0.478000													6	167					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	64					0	0	1	0	0
ZEB2	9839	broad.mit.edu	37	2	145157124	145157124	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr2:145157124T>C	ENST00000558170.2	-	8	2814	c.1630A>G	c.(1630-1632)Act>Gct	p.T544A	ZEB2_ENST00000303660.4_Missense_Mutation_p.T544A|ZEB2_ENST00000409487.3_Missense_Mutation_p.T544A|ZEB2_ENST00000539609.3_Missense_Mutation_p.T520A	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	544						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		GAGTCAGTAGTCAAGCTCTGG	0.388000													17	85					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	843541	843541	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr4:843541G>A	ENST00000314167.4	-	28	3966	c.3856C>T	c.(3856-3858)Cag>Tag	p.Q1286*	GAK_ENST00000509566.1_5'UTR|GAK_ENST00000511163.1_Nonsense_Mutation_p.Q1207*	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	1286	J.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		TTGGCGTGCTGCTCGTACGGC	0.677000													4	45					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240072244	240072244	+	Missense_Mutation	SNP	T	T	G			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr1:240072244T>G	ENST00000255380.4	+	5	2272	c.1493T>G	c.(1492-1494)cTt>cGt	p.L498R		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	498					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GCGATCTTGCTTGCCTTCATC	0.493000													34	80					0	0	1	0	0
SLC1A3	6507	broad.mit.edu	37	5	36629602	36629602	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr5:36629602G>T	ENST00000265113.4	+	3	708	c.232G>T	c.(232-234)Gtc>Ttc	p.V78F	SLC1A3_ENST00000381918.3_Missense_Mutation_p.V78F	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	78					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	CTACCGGGAAGTCAAGTACTT	0.398000													13	117					4.3838e-07	4.83342e-07	1	1	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													5	40					0	0	1	0	0
NAGK	55577	broad.mit.edu	37	2	71305538	71305538	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr2:71305538C>T	ENST00000418807.3	+	9	946	c.782C>T	c.(781-783)gCt>gTt	p.A261V	NAGK_ENST00000244204.5_Missense_Mutation_p.A312V|NAGK_ENST00000455662.2_Missense_Mutation_p.A358V			Q9UJ70	NAGK_HUMAN	N-acetylglucosamine kinase	312					N-acetylglucosamine metabolic process|N-acetylmannosamine metabolic process		ATP binding|N-acetylglucosamine kinase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|urinary_tract(1)	18					N-Acetyl-D-glucosamine(DB00141)	CACTCCTCCGCTCTGGGTGGG	0.582000													5	29					0	0	1	0	0
NAGK	55577	broad.mit.edu	37	2	71305537	71305537	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr2:71305537G>T	ENST00000418807.3	+	9	945	c.781G>T	c.(781-783)Gct>Tct	p.A261S	NAGK_ENST00000244204.5_Missense_Mutation_p.A312S|NAGK_ENST00000455662.2_Missense_Mutation_p.A358S			Q9UJ70	NAGK_HUMAN	N-acetylglucosamine kinase	312					N-acetylglucosamine metabolic process|N-acetylmannosamine metabolic process		ATP binding|N-acetylglucosamine kinase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|urinary_tract(1)	18					N-Acetyl-D-glucosamine(DB00141)	GCACTCCTCCGCTCTGGGTGG	0.582000													6	28					0.00198382	0.00203105	1	1	0
AC027612.3	0	broad.mit.edu	37	2	91887905	91887906	+	RNA	INS	-	-	T			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr2:91887905_91887906insT	ENST00000436174.1	-	0	540																											GCTATTTTCCATTTTTTTTTTT	0.292													8	28	---	---	---	---					
MUC3A	4584	broad.mit.edu	37	7	100606304	100606304	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr7:100606304delG	ENST00000319509.7	+	3	1820	c.1820delG	c.(1819-1821)tgfs	p.W607fs						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						AAGACCTTCTGGAATCAGGTA	0.483													2	4	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149505750	149505751	+	RNA	DEL	CT	CT	-			TCGA-QR-A6GU-01A-11D-A35D-08	TCGA-QR-A6GU-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab662ec9-f613-4fc7-822b-f365e38d20b8	954a0b13-b7eb-4aa1-be6d-b90151c1c6f1	g.chr7:149505750_149505751delCT	ENST00000378016.2	+	0	9121							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CAGGTGAGAGCTGGGACTGAGG	0.594													2	4	---	---	---	---