Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PER2	8864	broad.mit.edu	37	2	239186523	239186523	+	Missense_Mutation	SNP	C	C	A			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr2:239186523C>A	ENST00000254657.3	-	2	334	c.55G>T	c.(55-57)Gtg>Ttg	p.V19L	PER2_ENST00000254658.3_Missense_Mutation_p.V19L|PER2_ENST00000355768.2_Missense_Mutation_p.V19L|PER2_ENST00000440245.1_Missense_Mutation_p.V19L	NM_022817.2	NP_073728.1	O15055	PER2_HUMAN	period circadian clock 2	19					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		TGGGGCTCCACGGGCTCCTTG	0.612000													3	27					6.4e-05	7.168e-05	1	1	0
SLC22A2	6582	broad.mit.edu	37	6	160645781	160645781	+	Silent	SNP	C	C	T			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr6:160645781C>T	ENST00000366953.3	-	10	1815	c.1557G>A	c.(1555-1557)ggG>ggA	p.G519G	SLC22A2_ENST00000491092.1_5'UTR	NM_003058.3	NP_003049.2	O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	519					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		GCAAAGCTTTCCCTTTAGTTT	0.418000													23	70					0	0	1	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42832767	42832767	+	Silent	SNP	G	G	T			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr6:42832767G>T	ENST00000314073.5	+	13	2999	c.2823G>T	c.(2821-2823)cgG>cgT	p.R941R	GLTSCR1L_ENST00000394168.1_Silent_p.R941R					GLTSCR1-like																		AGGGGCACCGGAAAACCTCAT	0.547000													3	34					0.00024832	0.000257517	1	1	0
FRG1BP	284802	broad.mit.edu	37	20	29623239	29623239	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr20:29623239G>A	ENST00000439954.2	+	3	401	c.55G>A	c.(55-57)Gct>Act	p.A19T	FRG1B_ENST00000358464.4_Silent_p.E17E|FRG1B_ENST00000278882.3_Silent_p.E17E																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TACCCTGGGAGCTCCACACAA	0.408000													6	309					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63174996	63174996	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr14:63174996G>A	ENST00000322893.7	-	11	2465	c.2197C>T	c.(2197-2199)Caa>Taa	p.Q733*	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	733					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ACCTGGAGTTGGTTCCTCTCA	0.557000													19	60					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1272055	1272055	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr11:1272055G>A	ENST00000447027.1	+	31	14012	c.13954G>A	c.(13954-13956)Gcc>Acc	p.A4652T	MUC5B_ENST00000529681.1_Missense_Mutation_p.A4649T			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4649	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding	p.A4649T(1)|p.A4604T(1)		cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		cacccacaccgccagagtgct	0.612000													11	11					0	0	1	0	0
GABRA2	2555	broad.mit.edu	37	4	46252463	46252463	+	Missense_Mutation	SNP	T	T	G			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr4:46252463T>G	ENST00000510861.1	-	10	1391	c.1218A>C	c.(1216-1218)gaA>gaC	p.E406D	GABRA2_ENST00000507069.1_Missense_Mutation_p.E466D|GABRA2_ENST00000356504.1_Missense_Mutation_p.E406D|GABRA2_ENST00000381620.4_Missense_Mutation_p.E406D|GABRA2_ENST00000514090.1_Missense_Mutation_p.E406D|GABRA2_ENST00000540012.1_Missense_Mutation_p.E411D			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	406					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTTTCTTTGCTTCAGCTGGCT	0.403000													25	144					0	0	1	0	0
FNDC7	163479	broad.mit.edu	37	1	109270464	109270464	+	Missense_Mutation	SNP	G	G	T	rs142706173	byFrequency	TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr1:109270464G>T	ENST00000370017.3	+	7	1423	c.1146G>T	c.(1144-1146)ttG>ttT	p.L382F	FNDC7_ENST00000271311.2_Missense_Mutation_p.L383F	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	383	Fibronectin type-III 5.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		ACCCCGTGTTGGTGTCCAGTG	0.522000													18	112					1.45105e-14	1.69289e-14	1	1	0
STRN4	29888	broad.mit.edu	37	19	47228840	47228840	+	Silent	SNP	G	G	A	rs148663953	byFrequency	TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr19:47228840G>A	ENST00000391910.3	-	10	1785	c.1335C>T	c.(1333-1335)taC>taT	p.Y445Y	STRN4_ENST00000539396.1_Silent_p.Y319Y|STRN4_ENST00000594357.2_5'UTR|STRN4_ENST00000263280.6_Silent_p.Y438Y			Q9NRL3	STRN4_HUMAN	striatin, calmodulin binding protein 4	438						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		GAATGCCGTCGTAGTGCGAGC	0.607000													16	23					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21098274	21098274	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr16:21098274G>C	ENST00000261383.3	-	19	2772	c.2773C>G	c.(2773-2775)Cgc>Ggc	p.R925G	DNAH3_ENST00000415178.1_Missense_Mutation_p.R925G	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	925	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCTGCTAAGCGCCTGGGTGCA	0.463000													4	211					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209150561	209150561	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr2:209150561C>T	ENST00000264380.4	+	6	883	c.725C>T	c.(724-726)tCt>tTt	p.S242F	PIKFYVE_ENST00000407449.1_Missense_Mutation_p.S242F|PIKFYVE_ENST00000308862.6_Missense_Mutation_p.S156F|PIKFYVE_ENST00000392202.3_Missense_Mutation_p.S145F	NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	242					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						TCTGCTTGCTCTGTGTCTGTG	0.428000													4	88					0	0	1	0	0
NCR1	9437	broad.mit.edu	37	19	55421398	55421398	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr19:55421398C>T	ENST00000594765.1	+	5	680	c.655C>T	c.(655-657)Ctt>Ttt	p.L219F	NCR1_ENST00000338835.5_Missense_Mutation_p.L219F|NCR1_ENST00000350790.5_Missense_Mutation_p.L124F|NCR1_ENST00000291890.4_Missense_Mutation_p.L219F|NCR1_ENST00000357397.5_Missense_Mutation_p.L112F|NCR1_ENST00000447255.1_Missense_Mutation_p.L219F|NCR1_ENST00000598576.1_Missense_Mutation_p.L207F			O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	219					cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(193;0.0449)		GAACACCAGCCTTGCACCTGA	0.433000													16	135					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112182720	112182720	+	Silent	SNP	G	G	T			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr9:112182720G>T	ENST00000412145.1	-	9	3457	c.904C>A	c.(904-906)Cga>Aga	p.R302R	PTPN3_ENST00000374541.2_Silent_p.R433R|PTPN3_ENST00000262539.3_Silent_p.R279R|PTPN3_ENST00000446349.1_Silent_p.R257R	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	433	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						TGCGGGCTTCGGTTCTGAGAA	0.453000													4	47					0.00909568	0.00909568	1	1	0
CCDC88C	440193	broad.mit.edu	37	14	91875056	91875056	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr14:91875056G>A	ENST00000389857.6	-	3	303	c.217C>T	c.(217-219)Ctt>Ttt	p.L73F	CCDC88C_ENST00000389856.5_Missense_Mutation_p.L65F|CCDC88C_ENST00000553403.1_Missense_Mutation_p.L73F|CCDC88C_ENST00000554165.1_5'UTR	NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	73				L -> F (in Ref. 1; CQ719279).	microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				TGAATGCGAAGGTTCACATCA	0.458000													4	30					0	0	1	0	0
MMP14	4323	broad.mit.edu	37	14	23311796	23311796	+	Missense_Mutation	SNP	T	T	A			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr14:23311796T>A	ENST00000311852.6	+	4	819	c.558T>A	c.(556-558)caT>caA	p.H186Q	MMP14_ENST00000548162.1_3'UTR	NM_004995.2	NP_004986.1	P50281	MMP14_HUMAN	matrix metallopeptidase 14 (membrane-inserted)	186						extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	20	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		AGGGCTTCCATGGCGACAGCA	0.617000													11	32					0	0	1	0	0
NPY1R	4886	broad.mit.edu	37	4	164246696	164246696	+	Missense_Mutation	SNP	C	C	G			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr4:164246696C>G	ENST00000296533.2	-	3	1445	c.914G>C	c.(913-915)tGc>tCc	p.C305S	NPY1R_ENST00000509586.1_Missense_Mutation_p.C62S	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	305					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TGTGAGGTGGCAGAGCAGGAA	0.423000													6	47					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179596174	179596174	+	Silent	SNP	G	G	A			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr2:179596174G>A	ENST00000589042.1	-	59	17543	c.17319C>T	c.(17317-17319)gaC>gaT	p.D5773D	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Silent_p.D4529D|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Silent_p.D5456D	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5456	Ig-like 38.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTATATTATCGTCTTCAGTGA	0.483000													23	51					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	112987285	112987285	+	Silent	SNP	C	C	A			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr3:112987285C>A	ENST00000495514.1	+	5	1220	c.516C>A	c.(514-516)gcC>gcA	p.A172A	BOC_ENST00000273395.4_Silent_p.A172A|BOC_ENST00000355385.3_Silent_p.A172A			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	172	Ig-like C2-type 2.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			GGCTGGAGGCCTCCAGAGGTG	0.617000													3	15					0.00024832	0.000257517	1	1	0
MACROD2	140733	broad.mit.edu	37	20	15480461	15480461	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr20:15480461T>C	ENST00000217246.4	+	8	1009	c.614T>C	c.(613-615)aTt>aCt	p.I205T	MACROD2_ENST00000310348.4_Missense_Mutation_p.I205T|MACROD2_ENST00000402914.1_5'UTR	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	205	Macro.									breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				CTCAACACCATTAAGGAATGG	0.448000													20	26					0	0	1	0	0
POLE2	5427	broad.mit.edu	37	14	50146494	50146494	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr14:50146494G>C	ENST00000539565.2	-	3	412	c.194C>G	c.(193-195)tCt>tGt	p.S65C	POLE2_ENST00000553805.2_Missense_Mutation_p.S65C|POLE2_ENST00000216367.5_Missense_Mutation_p.S65C|POLE2_ENST00000554396.1_Missense_Mutation_p.S65C|POLE2_ENST00000556584.1_5'UTR	NM_001197330.1	NP_001184259.1	P56282	DPOE2_HUMAN	polymerase (DNA directed), epsilon 2, accessory subunit	65					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	10	all_epithelial(31;0.0021)|Breast(41;0.0124)					TTCCACCACAGATCGTTCAAT	0.368000													12	20					0	0	1	0	0
IGFBP3	3486	broad.mit.edu	37	7	45956263	45956263	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr7:45956263G>A	ENST00000275521.6	-	3	767	c.634C>T	c.(634-636)Ccc>Tcc	p.P212S	IGFBP3_ENST00000381086.5_Missense_Mutation_p.P115S|IGFBP3_ENST00000465642.1_5'UTR|IGFBP3_ENST00000381083.4_Missense_Mutation_p.P218S	NM_000598.4|NM_001013398.1	NP_000589.2|NP_001013416.1	P17936	IBP3_HUMAN	insulin-like growth factor binding protein 3	212	Thyroglobulin type-1.				negative regulation of protein phosphorylation|negative regulation of signal transduction|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of apoptosis|positive regulation of myoblast differentiation|protein phosphorylation|regulation of cell growth	nucleus	insulin-like growth factor I binding|metal ion binding|protein tyrosine phosphatase activator activity			large_intestine(6)|lung(7)|pancreas(1)|prostate(3)	17					Mecasermin(DB01277)	CTACGGCAGGGACCCTGGGGA	0.468000													5	83					0	0	1	0	0
PODNL1	79883	broad.mit.edu	37	19	14043665	14043665	+	Silent	SNP	C	C	T			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr19:14043665C>T	ENST00000538517.2	-	6	1363	c.1119G>A	c.(1117-1119)cgG>cgA	p.R373R	PODNL1_ENST00000339560.5_Silent_p.R464R|PODNL1_ENST00000538371.2_Silent_p.R462R|PODNL1_ENST00000254320.3_Silent_p.R382R	NM_001146255.1	NP_001139727.1	Q6PEZ8	PONL1_HUMAN	podocan-like 1	464	Leu-rich.					proteinaceous extracellular matrix				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(19;5.26e-23)			CGACCCGGAGCCGGTTGTGCG	0.692000													5	13					0	0	1	0	0
TEKT4P2	100132288	broad.mit.edu	37	21	9912066	9912068	+	RNA	DEL	CAG	CAG	-			TCGA-QR-A70G-01B-11D-A35D-08	TCGA-QR-A70G-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	464e014a-8df6-4ba6-b0f7-128a1030f757	b19a1c1b-4ef5-4159-a158-e1c3ae0cc556	g.chr21:9912066_9912068delCAG	ENST00000416067.1	-	0	129					NR_037872.1|NR_038327.1																						GCTTCTGGGCCAGCAGCAGGTCG	0.660													3	5	---	---	---	---