Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TACC2	10579	broad.mit.edu	37	10	123970864	123970864	+	Silent	SNP	C	C	A	rs116727041	by1000genomes	TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr10:123970864C>A	ENST00000369005.1	+	9	7264	c.6924C>A	c.(6922-6924)ccC>ccA	p.P2308P	TACC2_ENST00000368999.1_Silent_p.P386P|TACC2_ENST00000358010.1_Silent_p.P454P|TACC2_ENST00000369001.1_Silent_p.P12P|TACC2_ENST00000369000.1_Silent_p.P12P|TACC2_ENST00000360561.3_Silent_p.P386P|TACC2_ENST00000515603.1_Silent_p.P2263P|TACC2_ENST00000515273.1_Silent_p.P2312P|TACC2_ENST00000369004.3_Silent_p.P386P|TACC2_ENST00000334433.3_Silent_p.P2308P|TACC2_ENST00000453444.2_Silent_p.P2312P|TACC2_ENST00000513429.1_Silent_p.P454P|TACC2_ENST00000260733.3_Silent_p.P386P	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2308						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				AAAAGACACCCGAGAAACTTG	0.488000													30	92					3.80469e-20	4.15058e-20	1	1	0
CR1	1378	broad.mit.edu	37	1	207787753	207787753	+	Nonsense_Mutation	SNP	C	C	T	rs55749440		TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr1:207787753C>T	ENST00000367049.4	+	40	6580	c.6580C>T	c.(6580-6582)Cga>Tga	p.R2194*	CR1_ENST00000367052.1_Nonsense_Mutation_p.R1744*|CR1_ENST00000367053.1_Nonsense_Mutation_p.R1744*|CR1_ENST00000367051.1_Nonsense_Mutation_p.R1744*|CR1_ENST00000400960.2_Nonsense_Mutation_p.R1744*	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1744					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity	p.R1749*(9)|p.R2194*(9)|p.R1744*(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CTTTAGGTTCCGATTAAAAGG	0.423000													3	49					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3293277	3293277	+	Missense_Mutation	SNP	C	C	A	rs139092123	by1000genomes	TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr16:3293277C>A	ENST00000219596.1	-	10	2249	c.2210G>T	c.(2209-2211)aGa>aTa	p.R737I	MEFV_ENST00000339854.4_Missense_Mutation_p.R557I|MEFV_ENST00000536379.1_Missense_Mutation_p.R526I|MEFV_ENST00000541159.1_3'UTR	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	737	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	GATGTGGGATCTGGCTGTCAC	0.542000													4	88					2.56e-06	2.71059e-06	1	1	0
FAM86DP	692099	broad.mit.edu	37	3	75476706	75476706	+	RNA	SNP	C	C	T			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr3:75476706C>T	ENST00000459803.1	-	0	650					NR_024241.1																						TAATGAGAGGCCATTGAGAAG	0.602000													7	56					0	0	1	0	0
MMRN1	22915	broad.mit.edu	37	4	90816482	90816482	+	Silent	SNP	C	C	T	rs142099842		TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr4:90816482C>T	ENST00000394980.1	+	2	679	c.360C>T	c.(358-360)aaC>aaT	p.N120N	MMRN1_ENST00000394981.1_Silent_p.N86N|MMRN1_ENST00000264790.2_Silent_p.N120N			Q13201	MMRN1_HUMAN	multimerin 1	120					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TCCCAACCAACGCTAGCATCA	0.438000													16	65					0	0	1	0	0
IGKV1-5	28299	broad.mit.edu	37	2	89246997	89246997	+	RNA	SNP	T	T	C			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr2:89246997T>C	ENST00000496168.1	-	0	353																											TTTCTGCTGATACCAGGCCAA	0.532000													5	157					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7756355	7756355	+	Missense_Mutation	SNP	C	C	G			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr17:7756355C>G	ENST00000254846.5	+	21	5037	c.4648C>G	c.(4648-4650)Caa>Gaa	p.Q1550E	KDM6B_ENST00000448097.2_Missense_Mutation_p.Q1550E	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	1550					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						CTGCCAGGTGCAACGCGAGAG	0.627000													4	27					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69882049	69882049	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr10:69882049G>A	ENST00000358913.5	+	2	1342	c.854G>A	c.(853-855)cGa>cAa	p.R285Q	MYPN_ENST00000373675.3_Missense_Mutation_p.R285Q|MYPN_ENST00000354393.2_Intron|MYPN_ENST00000540630.1_Missense_Mutation_p.R285Q	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	285	Ig-like 1.|Interaction with CARP.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						GAAGGAACTCGAGTACAGTTG	0.468000													12	60					0	0	1	0	0
GLUD1P7	414212	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	A	G			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr10:48968566A>G	ENST00000594520.1	+	0	723																											ACAGGATAACAAACTGGAAAA	0.318000													4	27					0	0	1	0	0
CLASP2	23122	broad.mit.edu	37	3	33592821	33592821	+	Missense_Mutation	SNP	T	T	G			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr3:33592821T>G	ENST00000399362.4	-	30	3450	c.3097A>C	c.(3097-3099)Aat>Cat	p.N1033H	CLASP2_ENST00000480013.1_Missense_Mutation_p.N813H|CLASP2_ENST00000359576.5_Missense_Mutation_p.N1025H|CLASP2_ENST00000539981.1_Missense_Mutation_p.N803H|CLASP2_ENST00000461133.3_Missense_Mutation_p.N793H|CLASP2_ENST00000468888.2_Missense_Mutation_p.N1034H|CLASP2_ENST00000307312.7_Missense_Mutation_p.N515H	NM_015097.2	NP_055912.2	B2RTR1	B2RTR1_HUMAN	cytoplasmic linker associated protein 2	1035										breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	48						TCACTGGAATTTATAAAATCT	0.408000													21	58					0	0	1	0	0
IGHV3-38	28429	broad.mit.edu	37	14	106866492	106866492	+	RNA	SNP	A	A	T			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr14:106866492A>T	ENST00000390618.2	-	0	339																											TTGTCTCTGGAGATGGTGAAT	0.532000													8	221					0	0	1	0	0
RCOR1	23186	broad.mit.edu	37	14	103174910	103174910	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr14:103174910C>T	ENST00000262241.6	+	6	995	c.769C>T	c.(769-771)Cgg>Tgg	p.R257W	RCOR1_ENST00000570597.1_Missense_Mutation_p.R254W	NM_015156.3	NP_055971.2	Q9UKL0	RCOR1_HUMAN	REST corepressor 1	254					blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	12						AAAACGGGAGCGGGAGGAGAG	0.468000													6	205					0	0	1	0	0
MRPL24	79590	broad.mit.edu	37	1	156708205	156708205	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr1:156708205G>A	ENST00000368211.4	-	3	347	c.209C>T	c.(208-210)gCc>gTc	p.A70V	MRPL24_ENST00000361531.2_Missense_Mutation_p.A70V	NM_024540.3|NM_145729.2	NP_078816.2|NP_663781.1	Q96A35	RM24_HUMAN	mitochondrial ribosomal protein L24	70	KOW.				translation	mitochondrion|ribosome	structural constituent of ribosome			endometrium(1)|large_intestine(1)|lung(4)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTGCTTCCCGGCATCCTTGCC	0.567000													4	179					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175365905	175365905	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr1:175365905C>T	ENST00000367674.1	-	5	1723	c.1015G>A	c.(1015-1017)Gac>Aac	p.D339N	TNR_ENST00000263525.2_Missense_Mutation_p.D339N	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	339	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					ATGGACCTGTCGCTGATACCA	0.602000													5	172					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186544307	186544307	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr4:186544307C>T	ENST00000431808.1	-	14	2827	c.2264G>A	c.(2263-2265)aGc>aAc	p.S755N	SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000418609.1_Missense_Mutation_p.S659N|SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000355634.5_Missense_Mutation_p.S855N|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000284776.7_Missense_Mutation_p.S755N|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000448662.2_Intron			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	755						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GTGCAGGATGCTGTTGTCCGG	0.537000													4	229					0	0	1	0	0
RAB22A	57403	broad.mit.edu	37	20	56918775	56918775	+	Splice_Site	SNP	G	G	A			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr20:56918775G>A	ENST00000244040.3	+	3	399	c.116_splice	c.e3-1	p.A40_splice	RAB22A_ENST00000488949.1_3'UTR	NM_020673.2	NP_065724.1	Q9UL26	RB22A_HUMAN	RAB22A, member RAS oncogene family	40					endocytosis|endosome organization|protein transport|small GTPase mediated signal transduction	early endosome|endosome membrane|plasma membrane	GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(2)|pancreas(1)	6	all_epithelial(3;5.09e-14)|Lung NSC(12;0.000122)|all_lung(29;0.00042)		BRCA - Breast invasive adenocarcinoma(13;6.2e-12)|Epithelial(14;4.73e-08)|all cancers(14;4.83e-07)			TCTTTATAGGGCATCTTTTAT	0.403000													3	50					0	0	1	0	0
CPZ	8532	broad.mit.edu	37	4	8605723	8605723	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr4:8605723G>A	ENST00000382480.2	+	4	906	c.106G>A	c.(106-108)Gca>Aca	p.A36T	CPZ_ENST00000360986.4_Missense_Mutation_p.A173T|CPZ_ENST00000315782.6_Missense_Mutation_p.A162T|CPZ_ENST00000429646.2_5'UTR	NM_001014448.2	NP_001014448.1	Q66K79	CBPZ_HUMAN	carboxypeptidase Z	173	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GGCTGACGAGGCACTGCCCTC	0.687000													3	39					0	0	1	0	0
ROCK2	9475	broad.mit.edu	37	2	11333967	11333967	+	Nonsense_Mutation	SNP	G	G	A			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr2:11333967G>A	ENST00000315872.6	-	30	4073	c.3625C>T	c.(3625-3627)Cga>Tga	p.R1209*	ROCK2_ENST00000401753.1_Nonsense_Mutation_p.R966*	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	1209	PH.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		GTAACTGGTCGGACATGAAAT	0.299000													7	67					0	0	1	0	0
USP19	10869	broad.mit.edu	37	3	49151652	49151652	+	Silent	SNP	G	G	A			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr3:49151652G>A	ENST00000453664.1	-	16	2640	c.2322C>T	c.(2320-2322)ctC>ctT	p.L774L	USP19_ENST00000398888.2_Silent_p.L683L|USP19_ENST00000398892.3_Silent_p.L723L|USP19_ENST00000398896.1_Silent_p.L491L|USP19_ENST00000398898.2_Silent_p.L723L|USP19_ENST00000434032.2_Silent_p.L784L|USP19_ENST00000417901.1_Silent_p.L786L	NM_001199161.1|NM_001199162.1	NP_001186090.1|NP_001186091.1	O94966	UBP19_HUMAN	ubiquitin specific peptidase 19	683					ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AAAAGACAGGGAGAACCTTTT	0.547000													36	124					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460204	107460204	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr2:107460204C>T	ENST00000409382.3	-	2	840	c.230G>A	c.(229-231)cGc>cAc	p.R77H	ST6GAL2_ENST00000361686.4_Missense_Mutation_p.R77H|ST6GAL2_ENST00000409087.3_Missense_Mutation_p.R77H	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	77					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						CAGCGCCTGGCGTGCGTCCAG	0.677000													14	53					0	0	1	0	0
SPINK5	11005	broad.mit.edu	37	5	147504400	147504400	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr5:147504400G>T	ENST00000398454.1	+	28	2812	c.2739G>T	c.(2737-2739)aaG>aaT	p.K913N	SPINK5_ENST00000359874.3_Splice_Site_p.K913_splice|SPINK5_ENST00000256084.7_Splice_Site_p.K913_splice	NM_001127699.1	NP_001121171.1	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5	913	Kazal-like 14.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(8)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATAATGCAAAGGTTATTTATT	0.284000													5	16					0.00116845	0.00116845	1	1	0
TPK1	27010	broad.mit.edu	37	7	144462990	144462990	+	Missense_Mutation	SNP	C	C	T	rs77358162	byFrequency	TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr7:144462990C>T	ENST00000360057.3	-	3	200	c.98G>A	c.(97-99)cGt>cAt	p.R33H	TPK1_ENST00000378099.3_Missense_Mutation_p.R33H	NM_022445.3	NP_071890.2	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1	33					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			large_intestine(3)|lung(12)|ovary(2)|urinary_tract(2)	19					Thiamine(DB00152)	CCAAAGATGACGAAAATAGTT	0.328000													15	72					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22661208	22661208	+	RNA	SNP	C	C	T			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr22:22661208C>T	ENST00000426066.1	+	0	300					NR_027293.1																						CTGAATCATGCAGAATTTGAA	0.408000													4	59					0	0	1	0	0
MUC5AC	4586	broad.mit.edu	37	11	1155162	1155162	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr11:1155162C>T	ENST00000356191.2	+	3	170	c.170C>T	c.(169-171)gCg>gTg	p.A57V						mucin 5AC, oligomeric mucus/gel-forming											NS(1)|breast(2)|central_nervous_system(7)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(5)|kidney(9)|large_intestine(19)|liver(1)|lung(89)|ovary(7)|prostate(8)|skin(9)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	203		all_cancers(49;2.94e-05)|Breast(177;0.00257)|all_epithelial(84;0.00314)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.00146)|Lung(200;0.0612)|LUSC - Lung squamous cell carcinoma(625;0.0724)		CTCCGTGGGGCGACTGTCTTC	0.672000													3	23					0	0	1	0	0
GPR137	56834	broad.mit.edu	37	11	64056826	64056826	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr11:64056826C>T	ENST00000411458.1	+	9	1445	c.1417C>T	c.(1417-1419)Ccg>Tcg	p.P473S	GPR137_ENST00000313074.3_Missense_Mutation_p.P415S|GPR137_ENST00000539851.1_3'UTR|GPR137_ENST00000377702.4_3'UTR|GPR137_ENST00000438980.2_3'UTR	NM_001170726.1	NP_001164197.1	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	415						integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(4)|skin(1)	10						TGAGCTTGTGCCGTCCCCCTA	0.647000													4	86					0	0	1	0	0
WDR62	284403	broad.mit.edu	37	19	36585023	36585023	+	Silent	SNP	A	A	T			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr19:36585023A>T	ENST00000401500.2	+	20	2459	c.2424A>T	c.(2422-2424)ccA>ccT	p.P808P	WDR62_ENST00000270301.7_Silent_p.P808P	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	808					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			AGTGTGAGCCAGAAGAGATGC	0.488000													8	75					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22661206	22661206	+	RNA	SNP	T	T	C			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr22:22661206T>C	ENST00000426066.1	+	0	298					NR_027293.1																						AGCTGAATCATGCAGAATTTG	0.408000													4	57					0	0	1	0	0
TCF7L2	6934	broad.mit.edu	37	10	114910867	114910867	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr10:114910867G>A	ENST00000545257.1	+	9	1493	c.986G>A	c.(985-987)gGc>gAc	p.G329D	TCF7L2_ENST00000536810.1_Missense_Mutation_p.G329D|TCF7L2_ENST00000369397.4_Missense_Mutation_p.G306D|TCF7L2_ENST00000369389.1_Missense_Mutation_p.G40D|TCF7L2_ENST00000355995.4_Missense_Mutation_p.G329D|TCF7L2_ENST00000534894.1_Missense_Mutation_p.G329D|TCF7L2_ENST00000369386.1_5'UTR|TCF7L2_ENST00000355717.4_Missense_Mutation_p.G353D|TCF7L2_ENST00000538897.1_Missense_Mutation_p.G329D|TCF7L2_ENST00000542695.1_Missense_Mutation_p.G45D|TCF7L2_ENST00000543371.1_Missense_Mutation_p.G329D|TCF7L2_ENST00000352065.5_Missense_Mutation_p.G306D			Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 (T-cell specific, HMG-box)	329	Mediates interaction with MAD2L2.				anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding		VTI1A/TCF7L2(8)	central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(24)|liver(2)|lung(8)|ovary(1)|skin(1)	41		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		AGTGATGTCGGCTCACTCCAT	0.532000			T	VTI1A	colorectal								4	105					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17597607	17597607	+	Silent	SNP	C	C	T			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr1:17597607C>T	ENST00000375460.3	+	9	1021	c.981C>T	c.(979-981)gcC>gcT	p.A327A		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	327					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	CAGAGCTGGCCAGGAAGGCCG	0.647000													5	35					0	0	1	0	0
MEG3	55384	broad.mit.edu	37	14	101311732	101311734	+	RNA	DEL	CCT	CCT	-	rs61149909		TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr14:101311732_101311734delCCT	ENST00000554041.1	-	0	143																											CCTCATCCGCCCTCCTCCTCCTC	0.606													2	4	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26113543	26113543	+	RNA	DEL	A	A	-			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chr20:26113543delA	ENST00000416563.1	-	0	250																											TCTTTGCCTTAACAACATTAT	0.363													4	4	---	---	---	---					
FAM120C	54954	broad.mit.edu	37	X	54209302	54209303	+	In_Frame_Ins	INS	-	-	GGCGGC			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chrX:54209302_54209303insGGCGGC	ENST00000375180.2	-	1	385_386	c.329_330insGCCGCC	c.(328-330)ccc>cGCCGCCcc	p.109_110insRR	FAM120C_ENST00000477084.1_In_Frame_Ins_p.109_110insRR|FAM120C_ENST00000328235.4_In_Frame_Ins_p.109_110insRR	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	109										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						GCAGCTGAGGGGGCGGCGGCGG	0.748													2	4	---	---	---	---					
CD99L2	83692	broad.mit.edu	37	X	149984524	149984526	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-QR-A70J-01A-11D-A35D-08	TCGA-QR-A70J-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	030f6d72-2301-46e1-9970-35bf1a3f3b3a	10a4b987-2a12-433b-96e9-7d0dac568184	g.chrX:149984524_149984526delGTG	ENST00000370377.3	-	3	273_275	c.156_158delCAC	c.(154-159)aca>ac	p.TT52del	CD99L2_ENST00000437787.2_In_Frame_Del_p.TT52del|CD99L2_ENST00000355149.3_Intron|CD99L2_ENST00000466436.1_Intron|CD99L2_ENST00000346693.4_5'UTR	NM_001242614.1|NM_031462.3	NP_001229543.1|NP_113650.2	Q8TCZ2	C99L2_HUMAN	CD99 molecule-like 2	52	Poly-Thr.				cell adhesion	cell junction|integral to membrane				endometrium(4)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CCTATTGGTTGTGGTGGTGGTGG	0.552													7	168	---	---	---	---