Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANKRD19P	138649	broad.mit.edu	37	9	95646900	95646900	+	RNA	SNP	A	A	T			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr9:95646900A>T	ENST00000446878.1	+	0	434				ANKRD19P_ENST00000473204.1_RNA																							TGCTTTCACAACTGCAGAGGT	0.612000													7	130					0	0	1	0	0
OR52D1	390066	broad.mit.edu	37	11	5510364	5510364	+	Missense_Mutation	SNP	T	T	A			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr11:5510364T>A	ENST00000322641.5	+	1	450	c.428T>A	c.(427-429)gTc>gAc	p.V143D	HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|AC104389.28_ENST00000415970.1_RNA	NM_001005163.2	NP_001005163.1	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D, member 1	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AACCATGCTGTCATAGGCAGA	0.483000													6	113					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21606782	21606782	+	Missense_Mutation	SNP	A	A	G			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr19:21606782A>G	ENST00000392288.2	+	4	1430	c.1321A>G	c.(1321-1323)Acc>Gcc	p.T441A	CTD-2561J22.3_ENST00000600810.1_Intron|ZNF493_ENST00000355504.4_Missense_Mutation_p.T313A	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.T313A(1)		central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						ATGTGGCAAAACCTTTAGTGT	0.338000													3	36					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103400017	103400017	+	Silent	SNP	T	T	G			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr1:103400017T>G	ENST00000358392.2	-	46	3941	c.3624A>C	c.(3622-3624)ccA>ccC	p.P1208P	COL11A1_ENST00000353414.4_Silent_p.P1157P|COL11A1_ENST00000512756.1_Silent_p.P1080P|COL11A1_ENST00000370096.3_Silent_p.P1196P	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1196	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GAAGACCTATTGGACCAGGAG	0.468000													5	19					0	0	1	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38175553	38175553	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr8:38175553G>T	ENST00000316985.3	-	10	2376	c.1859C>A	c.(1858-1860)tCg>tAg	p.S620*	WHSC1L1_ENST00000527502.1_Intron|WHSC1L1_ENST00000433384.2_Intron|WHSC1L1_ENST00000317025.8_Intron|WHSC1L1_ENST00000525081.1_5'UTR	NM_017778.2	NP_060248.2	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	620					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			CCGGTCCGCCGACCCTGTGGA	0.557000			T	NUP98	AML								21	23					1.87028e-06	2.00882e-06	1	1	0
CCDC40	55036	broad.mit.edu	37	17	78058656	78058656	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr17:78058656G>A	ENST00000397545.4	+	13	2131	c.2104G>A	c.(2104-2106)Gtg>Atg	p.V702M	CCDC40_ENST00000374877.3_Missense_Mutation_p.V702M	NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	702					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GGACCAGGACGTGAAGAAAGT	0.562000													8	22					0	0	1	0	0
WARS2	10352	broad.mit.edu	37	1	119575971	119575971	+	Nonsense_Mutation	SNP	T	T	A			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr1:119575971T>A	ENST00000235521.4	-	6	672	c.646A>T	c.(646-648)Aag>Tag	p.K216*	WARS2_ENST00000537870.1_Nonsense_Mutation_p.K122*|WARS2_ENST00000369426.5_3'UTR	NM_015836.3|NM_201263.2	NP_056651.1|NP_957715.1	Q9UGM6	SYWM_HUMAN	tryptophanyl tRNA synthetase 2, mitochondrial	216					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(2)	15	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	GATTTTACCTTCTTCATGGAT	0.438000													17	94					0	0	1	0	0
TRAF2	7186	broad.mit.edu	37	9	139804402	139804402	+	Missense_Mutation	SNP	T	T	G			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr9:139804402T>G	ENST00000359662.3	+	6	760	c.715T>G	c.(715-717)Tta>Gta	p.L239V	TRAF2_ENST00000247668.2_Missense_Mutation_p.L187V|TRAF2_ENST00000482854.1_3'UTR|TRAF2_ENST00000536468.1_Missense_Mutation_p.L187V			Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	187				Missing (in Ref. 2; BAB70792).	activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)		CAAGTTCCCCTTAACTTGTGA	0.627000													13	14					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22661272	22661272	+	RNA	SNP	C	C	T			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr22:22661272C>T	ENST00000426066.1	+	0	360					NR_027293.1																						CTGGGATGTACGTCTGCGTTG	0.488000													4	45					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208212983	208212983	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr1:208212983T>C	ENST00000367033.3	-	24	5240	c.4483A>G	c.(4483-4485)Atc>Gtc	p.I1495V		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	1495					axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		TTGTACTCGATCTGCTGCCGG	0.582000													10	49					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70504190	70504190	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr1:70504190G>A	ENST00000310961.5	+	22	3002	c.2584G>A	c.(2584-2586)Gct>Act	p.A862T	LRRC7_ENST00000415775.2_Missense_Mutation_p.A141T|LRRC7_ENST00000035383.5_Missense_Mutation_p.A857T			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	857						centrosome|focal adhesion|nucleolus	protein binding	p.A857T(1)		breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AGACAGGACCGCTTTTCCTTC	0.468000													10	39					0	0	1	0	0
ALS2	57679	broad.mit.edu	37	2	202619377	202619377	+	Missense_Mutation	SNP	T	T	C			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr2:202619377T>C	ENST00000264276.6	-	6	1861	c.1489A>G	c.(1489-1491)Aga>Gga	p.R497G		NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	497					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						GCAGCCTTTCTTAAGAGCCTG	0.498000													11	50					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103400018	103400018	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr1:103400018G>T	ENST00000358392.2	-	46	3940	c.3623C>A	c.(3622-3624)cCa>cAa	p.P1208Q	COL11A1_ENST00000353414.4_Missense_Mutation_p.P1157Q|COL11A1_ENST00000512756.1_Missense_Mutation_p.P1080Q|COL11A1_ENST00000370096.3_Missense_Mutation_p.P1196Q	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1196	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AAGACCTATTGGACCAGGAGG	0.468000													5	21					1.23904e-05	1.28329e-05	1	1	0
CD163	9332	broad.mit.edu	37	12	7651662	7651662	+	Missense_Mutation	SNP	A	A	T			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr12:7651662A>T	ENST00000359156.4	-	4	782	c.580T>A	c.(580-582)Tct>Act	p.S194T	CD163_ENST00000432237.2_Missense_Mutation_p.S194T|CD163_ENST00000396620.3_Missense_Mutation_p.S194T|CD163_ENST00000541972.1_Missense_Mutation_p.S182T	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	194	SRCR 2.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						CAAATGACAGATGCATGATCT	0.423000													8	160					0	0	1	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140753701	140753701	+	Silent	SNP	C	C	A			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr5:140753701C>A	ENST00000517434.1	+	1	51	c.51C>A	c.(49-51)ctC>ctA	p.L17L	PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTGCTCCTCACGCTCCTGG	0.597000													3	17					0.004672	0.004672	1	1	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								4	61					0	0	1	0	0
VHL	7428	broad.mit.edu	37	3	10188286	10188286	+	Missense_Mutation	SNP	C	C	G			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr3:10188286C>G	ENST00000256474.2	+	2	1269	c.429C>G	c.(427-429)gaC>gaG	p.D143E	VHL_ENST00000345392.2_Intron|VHL_ENST00000477538.1_3'UTR	NM_000551.3	NP_000542.1	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	143	Involved in binding to CCT complex.		D -> E (in VHLD; type II).		anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.G144fs*14(4)|p.D143E(2)|p.D143fs*16(2)|p.V142fs*30(1)|p.Q145fs*30(1)|p.D143fs*29(1)|p.N141fs*30(1)|p.S139fs*12(1)|p.G144fs*19(1)		adrenal_gland(25)|autonomic_ganglia(3)|central_nervous_system(2)|endometrium(6)|kidney(1662)|large_intestine(14)|lung(6)|pancreas(18)|paratesticular_tissues(1)|pleura(1)|skin(1)|soft_tissue(24)|thyroid(3)|upper_aerodigestive_tract(3)	1769				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		TCAATGTTGACGGACAGCCTA	0.423000		1	"""D, Mis, N, F, S"""		"""renal, hemangioma, pheochromocytoma"""	"""renal, hemangioma, pheochromocytoma"""			von Hippel-Lindau disease;Pheochromocytoma (Adrenal), Familial;Chuvash Polycythemia				59	59					0	0	1	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17111301	17111301	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr11:17111301G>A	ENST00000265970.7	-	32	5044	c.5045C>T	c.(5044-5046)gCg>gTg	p.A1682V	PIK3C2A_ENST00000531428.1_Intron|PIK3C2A_ENST00000540361.1_Missense_Mutation_p.A1302V	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	1682					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	GTATGTTGCCGCAGTCAGCTG	0.428000													3	64					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43155495	43155496	+	RNA	INS	-	-	G			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr8:43155495_43155496insG	ENST00000522175.2	+	0	590							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						TTCCAAGGGAAGAGCAGTGTGT	0.386													4	3	---	---	---	---					
ZFC3H1	196441	broad.mit.edu	37	12	72030395	72030395	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr12:72030395delG	ENST00000378743.3	-	9	2333	c.1975delC	c.(1975-1977)tgfs	p.L659fs		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	659					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						GAATTGTTCAGAACTGGAGGT	0.383													22	56	---	---	---	---					
MBD3L5	284428	broad.mit.edu	37	19	7032331	7032332	+	Frame_Shift_Ins	INS	-	-	A			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr19:7032331_7032332insA	ENST00000329753.5	+	2	87_88	c.53_54insA	c.(52-54)caafs	p.Q18fs		NM_001136507.1	NP_001129979.1	A6NJ08	MB3L5_HUMAN	methyl-CpG binding domain protein 3-like 5	18																	AAGGGGAAGCTCAAAAGAAACA	0.485													2	4	---	---	---	---					
MAP3K10	4294	broad.mit.edu	37	19	40719906	40719917	+	In_Frame_Del	DEL	CCCTCCCCACCA	CCCTCCCCACCA	-			TCGA-QR-A70N-01A-12D-A35D-08	TCGA-QR-A70N-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffd4f038-8b57-4f33-b442-576ad662a41e	7a4b6abb-dee6-4d5d-9c6b-39fe7c7c4f60	g.chr19:40719906_40719917delCCCTCCCCACCA	ENST00000253055.3	+	9	2608_2619	c.2320_2331delCCCTCCCCACCA	c.(2320-2331)del	p.PSPP778del		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	778					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						ACCGGccgcgccctccccaccaccctccccgc	0.717													7	5	---	---	---	---