Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANO8	57719	broad.mit.edu	37	19	17444305	17444305	+	Silent	SNP	G	G	A			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr19:17444305G>A	ENST00000159087.4	-	3	434	c.276C>T	c.(274-276)ccC>ccT	p.P92P		NM_020959.2	NP_066010.1	Q9HCE9	ANO8_HUMAN	anoctamin 8	92						chloride channel complex	chloride channel activity			autonomic_ganglia(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(3)	27						CGATGAGCTCGGGAATGCCCA	0.652000													4	92					0	0	1	0	0
C10orf91	170393	broad.mit.edu	37	10	134261549	134261549	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr10:134261549C>T	ENST00000392630.3	+	3	483	c.422C>T	c.(421-423)gCg>gTg	p.A141V	C10orf91_ENST00000321248.2_Missense_Mutation_p.A141V	NM_173541.2	NP_775812.1	Q5T1B1	CJ091_HUMAN	chromosome 10 open reading frame 91	141										endometrium(1)|kidney(1)|lung(1)|ovary(2)	5		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;6.95e-05)|Epithelial(32;0.000142)|all cancers(32;0.000162)		TTCAGGAATGCGGCCTTCGAA	0.662000													4	91					0	0	1	0	0
LINC00933	100506874	broad.mit.edu	37	15	85121267	85121267	+	RNA	SNP	C	C	T	rs144259916	by1000genomes	TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr15:85121267C>T	ENST00000557887.1	+	0	467					NR_038273.1|NR_038274.1																						GGAGGCCAGCCGAACACACAG	0.473000													4	67					0	0	1	0	0
KRT8	3856	broad.mit.edu	37	12	53295659	53295659	+	Silent	SNP	G	G	A			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr12:53295659G>A	ENST00000552551.1	-	3	954	c.522C>T	c.(520-522)gaC>gaT	p.D174D	KRT8_ENST00000552150.1_Silent_p.D202D|KRT8_ENST00000293308.6_Silent_p.D174D|KRT8_ENST00000546897.1_Silent_p.D174D			P05787	K2C8_HUMAN	keratin 8	174	Coil 1B.|Rod.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			endometrium(5)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGTTCTTGAAGTCCTCCACCA	0.592000													13	18					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48327637	48327637	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr7:48327637G>A	ENST00000435803.1	+	20	8941	c.8917G>A	c.(8917-8919)Gct>Act	p.A2973T		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2973					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CATTTTATCTGCTATACAAGG	0.448000													4	89					0	0	1	0	0
PTTG1IP	754	broad.mit.edu	37	21	46271411	46271411	+	Silent	SNP	G	G	A			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr21:46271411G>A	ENST00000445724.2	-	3	374	c.300C>T	c.(298-300)tgC>tgT	p.C100C	PTTG1IP_ENST00000397886.3_3'UTR|PTTG1IP_ENST00000330938.3_3'UTR|PTTG1IP_ENST00000397887.3_3'UTR			P53801	PTTG_HUMAN	pituitary tumor-transforming 1 interacting protein	0					protein import into nucleus	cytoplasm|integral to membrane|nucleus				ovary(1)|prostate(1)	2				Colorectal(79;0.0659)		TCAGGAGACCGCAATGGCCAC	0.622000													3	37					0	0	1	0	0
ATP9B	374868	broad.mit.edu	37	18	76886309	76886309	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr18:76886309G>C	ENST00000426216.2	+	5	618	c.601G>C	c.(601-603)Gaa>Caa	p.E201Q	ATP9B_ENST00000591464.1_3'UTR|ATP9B_ENST00000307671.7_Missense_Mutation_p.E201Q	NM_198531.3	NP_940933.3	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	201					ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(3)|prostate(1)|skin(2)|stomach(1)	38		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		AGCAATTGATGAATTTCGGCG	0.348000													5	79					0	0	1	0	0
KRTAP5-1	387264	broad.mit.edu	37	11	1606265	1606265	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr11:1606265G>C	ENST00000382171.2	-	1	248	c.215C>G	c.(214-216)tCt>tGt	p.S72C	KRTAP5-AS1_ENST00000532922.1_RNA|KRTAP5-AS1_ENST00000534077.1_RNA|KRTAP5-AS1_ENST00000424148.1_RNA|KRTAP5-AS1_ENST00000524947.1_RNA	NM_001005922.1	NP_001005922.1	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	72	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(3)|kidney(1)|lung(9)|skin(2)|upper_aerodigestive_tract(1)	16		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GGAGCCCCCAGAAGAGCCACA	0.677000													3	103					0	0	1	0	0
LMAN2L	81562	broad.mit.edu	37	2	97373550	97373550	+	Silent	SNP	A	A	G			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr2:97373550A>G	ENST00000264963.4	-	7	827	c.805T>C	c.(805-807)Ttg>Ctg	p.L269L	LMAN2L_ENST00000537039.1_Silent_p.L131L|LMAN2L_ENST00000534882.1_Silent_p.L124L|LMAN2L_ENST00000426463.2_Silent_p.L135L|LMAN2L_ENST00000377079.4_Silent_p.L280L	NM_030805.3	NP_110432.1	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like	269	L-type lectin-like.				ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding			NS(1)|breast(1)|endometrium(1)|lung(2)|skin(1)|urinary_tract(1)	7						AACAACTTCAAGGAAATGACA	0.418000													4	75					0	0	1	0	0
SLC22A11	55867	broad.mit.edu	37	11	64323500	64323500	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr11:64323500C>T	ENST00000301891.4	+	1	403	c.29C>T	c.(28-30)gCc>gTc	p.A10V	SLC22A11_ENST00000490834.1_3'UTR|SLC22A11_ENST00000377581.3_Missense_Mutation_p.A10V|SLC22A11_ENST00000377585.3_Missense_Mutation_p.A10V	NM_018484.2	NP_060954.1	Q9NSA0	S22AB_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 11	10					urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23					Probenecid(DB01032)	TTGGAGCAAGCCGGAGGCGTG	0.592000											OREG0004031	type=REGULATORY REGION|Gene=SLC22A11|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	3	29					0	0	1	0	0
SHC1	6464	broad.mit.edu	37	1	154942999	154942999	+	Missense_Mutation	SNP	C	C	G			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr1:154942999C>G	ENST00000448116.2	-	1	224	c.4G>C	c.(4-6)Gat>Cat	p.D2H	SHC1_ENST00000368450.1_Intron|SHC1_ENST00000606391.1_Missense_Mutation_p.D2H|SHC1_ENST00000368449.4_5'UTR|SHC1_ENST00000368445.5_Missense_Mutation_p.D2H|SHC1_ENST00000368453.4_Intron	NM_001130040.1	NP_001123512.1	P29353	SHC1_HUMAN	SHC (Src homology 2 domain containing) transforming protein 1	2				D -> N (in Ref. 3; CAA70977).	activation of MAPK activity|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|positive regulation of DNA replication|Ras protein signal transduction|regulation of epidermal growth factor receptor activity|regulation of growth	cytosol|mitochondrial matrix|Shc-EGFR complex	epidermal growth factor receptor binding|insulin receptor binding|insulin-like growth factor receptor binding|phospholipid binding|protein binding|transmembrane receptor protein tyrosine kinase adaptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	20	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGCAGGAGATCCATAGTTGAG	0.647000													32	28					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61833944	61833944	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr10:61833944C>T	ENST00000280772.1	-	37	6886	c.6695G>A	c.(6694-6696)cGg>cAg	p.R2232Q	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2232					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GCTTAAAACCCGATTGTGGTC	0.413000													6	127					0	0	1	0	0
QSOX2	169714	broad.mit.edu	37	9	139118701	139118701	+	Silent	SNP	G	G	A			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr9:139118701G>A	ENST00000358701.5	-	2	385	c.348C>T	c.(346-348)cgC>cgT	p.R116R		NM_181701.3	NP_859052.3	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2	116	Thioredoxin.				cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		GAGCTGCGACGCGAATGGCAC	0.607000											OREG0019616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	35					0	0	1	0	0
TIGD7	91151	broad.mit.edu	37	16	3350052	3350052	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr16:3350052G>A	ENST00000396862.1	-	2	2391	c.563C>T	c.(562-564)cCa>cTa	p.P188L	TIGD7_ENST00000268674.2_Missense_Mutation_p.P188L	NM_033208.3	NP_149985.2	Q6NT04	TIGD7_HUMAN	tigger transposable element derived 7	188	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						agaattttctggcattgactt	0.408000													7	160					0	0	1	0	0
GOLGA6L17P	642402	broad.mit.edu	37	15	85053124	85053124	+	RNA	SNP	G	G	T			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr15:85053124G>T	ENST00000414190.2	-	0	328					NR_003246.2																						TAAATGTTTTGTTTTTTTTTT	0.353000													3	10					0.014758	0.014758	1	1	0
FAM66B	100128890	broad.mit.edu	37	8	7196263	7196264	+	RNA	DEL	AC	AC	-			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr8:7196263_7196264delAC	ENST00000606573.1	-	0	703																											ACTGAGGGGTacacacacacac	0.500													3	3	---	---	---	---					
RRN3P2	653390	broad.mit.edu	37	16	29113498	29113498	+	RNA	DEL	T	T	-	rs11366120		TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr16:29113498delT	ENST00000564580.1	+	0	1360																											AGGAGGTGGAttttttttttc	0.542													4	6	---	---	---	---					
FAM98C	147965	broad.mit.edu	37	19	38899502	38899504	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-QR-A70X-01A-11D-A35D-08	TCGA-QR-A70X-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9741731b-8f71-465d-9cfb-9e54e678c9a4	e8eec443-4a55-41f4-8ed4-c77c8bc2d3e1	g.chr19:38899502_38899504delAAG	ENST00000252530.5	+	8	1049_1051	c.1030_1032delAAG	c.(1030-1032)del	p.K349del	FAM98C_ENST00000343358.7_In_Frame_Del_p.K267del|FAM98C_ENST00000588262.1_3'UTR	NM_174905.3	NP_777565.3	Q17RN3	FA98C_HUMAN	family with sequence similarity 98, member C	349										endometrium(2)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TTGGGGTCGCAAGAAGAAGAAGA	0.606													7	53	---	---	---	---