Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NLRP4	147945	broad.mit.edu	37	19	56369263	56369263	+	Silent	SNP	G	G	A			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr19:56369263G>A	ENST00000301295.6	+	3	926	c.504G>A	c.(502-504)ctG>ctA	p.L168L	NLRP4_ENST00000346986.5_Silent_p.L168L|NLRP4_ENST00000587891.1_Silent_p.L93L	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	168	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TGATGAAGCTGATGATGGCCT	0.502000													28	58					0	0	1	0	0
NUP50	10762	broad.mit.edu	37	22	45574145	45574145	+	Missense_Mutation	SNP	A	A	G			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr22:45574145A>G	ENST00000347635.3	+	5	833	c.367A>G	c.(367-369)Acc>Gcc	p.T123A	NUP50_ENST00000486184.1_3'UTR|NUP50_ENST00000425733.2_5'UTR|NUP50_ENST00000407019.2_Missense_Mutation_p.T95A|NUP50_ENST00000396096.2_Missense_Mutation_p.T95A	NM_007172.3	NP_009103.2	Q9UKX7	NUP50_HUMAN	nucleoporin 50kDa	123	5 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|intracellular transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore|nucleoplasm	protein binding	p.T123A(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TGGCCCTACCACCTTGGTTGA	0.403000													5	108					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112686863	112686863	+	Silent	SNP	A	A	T			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr2:112686863A>T	ENST00000295408.4	+	2	485	c.228A>T	c.(226-228)ggA>ggT	p.G76G	MERTK_ENST00000421804.2_Silent_p.G76G|MERTK_ENST00000409780.1_Intron			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	76					cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						CACATACAGGAAACGTAGCCA	0.507000													18	16					0	0	1	0	0
MATR3	9782	broad.mit.edu	37	5	138651823	138651823	+	Missense_Mutation	SNP	C	C	T			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr5:138651823C>T	ENST00000394800.2	+	9	1624	c.1075C>T	c.(1075-1077)Cca>Tca	p.P359S	MATR3_ENST00000502499.1_Missense_Mutation_p.P21S|MATR3_ENST00000361059.2_Missense_Mutation_p.P359S|MATR3_ENST00000503811.1_Missense_Mutation_p.P71S|MATR3_ENST00000502929.1_Missense_Mutation_p.P359S|MATR3_ENST00000394805.3_Missense_Mutation_p.P359S|MATR3_ENST00000504203.1_Missense_Mutation_p.P21S|MATR3_ENST00000509990.1_Missense_Mutation_p.P359S|MATR3_ENST00000510056.1_Missense_Mutation_p.P359S			P43243	MATR3_HUMAN	matrin 3	359						nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			breast(2)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TCTGGGACCTCCACCTCCCTC	0.413000													26	69					0	0	1	0	0
KLHDC3	116138	broad.mit.edu	37	6	42987098	42987098	+	Missense_Mutation	SNP	A	A	G			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr6:42987098A>G	ENST00000326974.4	+	10	1271	c.1076A>G	c.(1075-1077)gAt>gGt	p.D359G	KLHDC3_ENST00000332245.8_Missense_Mutation_p.D300G|KLHDC3_ENST00000244670.8_Missense_Mutation_p.D225G	NM_057161.3	NP_476502.1	Q9BQ90	KLDC3_HUMAN	kelch domain containing 3	359					reciprocal meiotic recombination	cytoplasm|nuclear chromatin	chromatin binding|protein binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			TTGCCTCATGATATCAGGTAC	0.498000													76	84					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72937759	72937759	+	Silent	SNP	C	C	T			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr17:72937759C>T	ENST00000328801.4	+	2	345	c.345C>T	c.(343-345)gcC>gcT	p.A115A		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	115						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					ACAAGGTGGCCGTCACTCTGG	0.602000													22	35					0	0	1	0	0
ZACN	353174	broad.mit.edu	37	17	74075788	74075788	+	Missense_Mutation	SNP	C	C	G			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr17:74075788C>G	ENST00000334586.5	+	3	311	c.228C>G	c.(226-228)atC>atG	p.I76M	ZACN_ENST00000392503.2_Intron	NM_180990.3	NP_851321.2	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	76					response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	11						CCCAGGACATCCTGCGATACA	0.582000													4	45					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61486850	61486850	+	Missense_Mutation	SNP	A	A	G			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr2:61486850A>G	ENST00000398571.2	-	44	5916	c.5840T>C	c.(5839-5841)tTa>tCa	p.L1947S		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	1947					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			ACATACCATTAAATATGTAAA	0.408000													25	29					0	0	1	0	0
UCKL1	54963	broad.mit.edu	37	20	62571398	62571398	+	Silent	SNP	G	G	A			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr20:62571398G>A	ENST00000369908.5	-	15	1832	c.1533C>T	c.(1531-1533)ggC>ggT	p.G511G	UCKL1_ENST00000358711.3_3'UTR|UCKL1_ENST00000354216.6_Silent_p.G526G|UCKL1_ENST00000369892.3_Silent_p.G526G	NM_001193379.1	NP_001180308.1	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	526					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity			endometrium(3)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					AGTAGCGGTCGCCAAAGTTCC	0.682000													3	27					0	0	1	0	0
ESX1	80712	broad.mit.edu	37	X	103495314	103495314	+	Silent	SNP	G	G	T			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chrX:103495314G>T	ENST00000372588.4	-	4	899	c.816C>A	c.(814-816)ccC>ccA	p.P272P		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	272	15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						CAGGCGCcatgggtggcatag	0.687000													54	58					6.56871e-35	7.20439e-35	1	1	0
REPIN1	29803	broad.mit.edu	37	7	150066802	150066802	+	Translation_Start_Site	SNP	T	T	A			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr7:150066802T>A	ENST00000479668.1	+	2	90	c.2T>A	c.(1-3)aTg>aAg	p.M1K	REPIN1_ENST00000466559.1_Intron|REPIN1_ENST00000518514.1_Intron|REPIN1_ENST00000397281.2_5'UTR|RP4-584D14.5_ENST00000488310.1_RNA|REPIN1_ENST00000482680.1_Start_Codon_SNP_p.M1K|REPIN1_ENST00000489432.2_Start_Codon_SNP_p.M1K|REPIN1_ENST00000540729.1_5'UTR|REPIN1_ENST00000518462.1_Intron|REPIN1_ENST00000444957.1_Intron			Q9BWE0	REPI1_HUMAN	replication initiator 1	0					DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			cervix(2)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			AGCTCTGCCATGGGGATAGGG	0.587000													30	21					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409427	105409427	+	Silent	SNP	G	G	A			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr14:105409427G>A	ENST00000333244.5	-	7	12480	c.12361C>T	c.(12361-12363)Ctg>Ttg	p.L4121L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4121						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTGTCGGCCAGGGACAGGTCC	0.587000													6	520					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228547476	228547476	+	Missense_Mutation	SNP	G	G	A			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr1:228547476G>A	ENST00000284548.11	+	81	18957	c.18883G>A	c.(18883-18885)Ggc>Agc	p.G6295S	OBSCN_ENST00000366709.4_Missense_Mutation_p.G3414S|OBSCN_ENST00000366707.4_Intron|OBSCN_ENST00000570156.2_Intron|OBSCN_ENST00000422127.1_Intron			Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	7118					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGCAGAACCAGGCCAGAAGCC	0.706000													13	8					0	0	1	0	0
LOC644669	644669	broad.mit.edu	37	18	15323276	15323276	+	RNA	SNP	A	A	T			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr18:15323276A>T	ENST00000455308.2	-	0	572					NR_027417.1																						ATCAACTGCAATTGCATTTGC	0.308000													4	23					0	0	1	0	0
SLC26A9	115019	broad.mit.edu	37	1	205884502	205884502	+	Missense_Mutation	SNP	T	T	G			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr1:205884502T>G	ENST00000367135.3	-	21	2472	c.2359A>C	c.(2359-2361)Acc>Ccc	p.T787P	SLC26A9_ENST00000340781.4_Missense_Mutation_p.T787P|SLC26A9_ENST00000367134.2_Missense_Mutation_p.T787P	NM_052934.3	NP_443166.1	Q7LBE3	S26A9_HUMAN	solute carrier family 26 (anion exchanger), member 9	787						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			NS(1)|breast(3)|endometrium(11)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|skin(7)|urinary_tract(5)	52	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			GCGGTCAGGGTCTCTGCGTGA	0.592000													34	95					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38639331	38639331	+	Silent	SNP	C	C	T			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr3:38639331C>T	ENST00000413689.1	-	14	2344	c.2151G>A	c.(2149-2151)ccG>ccA	p.P717P	SCN5A_ENST00000423572.2_Silent_p.P717P|SCN5A_ENST00000414099.2_Silent_p.P717P|SCN5A_ENST00000451551.2_Silent_p.P717P|SCN5A_ENST00000450102.2_Silent_p.P717P|SCN5A_ENST00000449557.2_Silent_p.P717P|SCN5A_ENST00000443581.1_Silent_p.P717P|SCN5A_ENST00000333535.4_Silent_p.P717P|SCN5A_ENST00000425664.1_Silent_p.P717P|SCN5A_ENST00000455624.2_Silent_p.P717P	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	717					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GGTCAGTAAACGGGTCCATGA	0.547000													29	12					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29625905	29625905	+	Missense_Mutation	SNP	T	T	C	rs137871677	by1000genomes	TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr20:29625905T>C	ENST00000278882.3	+	5	529	c.149T>C	c.(148-150)cTt>cCt	p.L50P	FRG1B_ENST00000358464.4_Missense_Mutation_p.L50P|FRG1B_ENST00000439954.2_Missense_Mutation_p.L55P														p.L50P(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGAAAATATCTTGGTATAAAT	0.333000													6	116					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2046698	2046698	+	Silent	SNP	G	G	A			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr8:2046698G>A	ENST00000262113.4	+	19	2466	c.2325G>A	c.(2323-2325)ttG>ttA	p.L775L	MYOM2_ENST00000523438.1_Silent_p.L200L	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	775	Fibronectin type-III 4.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TGGACGGCTTGACGGAAGGCT	0.507000													16	24					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162462	90162462	+	RNA	SNP	A	A	G			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr16:90162462A>G	ENST00000567960.1	+	0	1198				TUBB8P7_ENST00000564451.1_RNA														p.T398T(1)									ACTGGTACACAGGCGAGGGCA	0.522000													5	106					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13601677	13601677	+	Missense_Mutation	SNP	G	G	C			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr4:13601677G>C	ENST00000040738.5	-	10	6982	c.6847C>G	c.(6847-6849)Cca>Gca	p.P2283A		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	2283							DNA binding										TCTTCCGCTGGTGTGACTGAG	0.562000													14	13					0	0	1	0	0
SOWAHB	345079	broad.mit.edu	37	4	77818089	77818090	+	In_Frame_Ins	INS	-	-	GCT	rs140725545	by1000genomes	TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr4:77818089_77818090insGCT	ENST00000334306.2	-	1	912_913	c.913_914insAGC	c.(913-915)cac>AGCcac	p.304_305insS		NM_001029870.1	NP_001025041.1	A6NEL2	ANR56_HUMAN	sosondowah ankyrin repeat domain family member B	304	Poly-Gln.																CTCTCGAGTGCGCTGCTGCTGC	0.713													8	10	---	---	---	---					
NBN	4683	broad.mit.edu	37	8	90982714	90982714	+	Frame_Shift_Del	DEL	T	T	-			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr8:90982714delT	ENST00000265433.3	-	7	928	c.774delA	c.(772-774)gafs	p.E259fs	NBN_ENST00000409330.1_Frame_Shift_Del_p.E177fs	NM_002485.4	NP_002476.2	O60934	NBN_HUMAN	nibrin	259					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(11;0.0344)			AATTATGTTCTTCTTCATTCT	0.378								Homologous recombination					27	83	---	---	---	---					
KCNMA1	3778	broad.mit.edu	37	10	78729786	78729786	+	Frame_Shift_Del	DEL	T	T	-			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr10:78729786delT	ENST00000286627.5	-	19	3084	c.2132delA	c.(2131-2133)agfs	p.K711fs	KCNMA1_ENST00000404771.3_Frame_Shift_Del_p.K769fs|KCNMA1_ENST00000372443.1_Frame_Shift_Del_p.K711fs|KCNMA1_ENST00000406533.3_Frame_Shift_Del_p.K773fs|RP11-443A13.5_ENST00000600782.1_RNA|RP11-443A13.5_ENST00000458661.2_RNA|KCNMA1_ENST00000354353.5_Frame_Shift_Del_p.K772fs|KCNMA1_ENST00000372440.1_Frame_Shift_Del_p.K711fs|KCNMA1_ENST00000404857.1_Frame_Shift_Del_p.K711fs|RP11-443A13.5_ENST00000598613.1_RNA|KCNMA1_ENST00000286628.8_Frame_Shift_Del_p.K769fs	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	706					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity	p.K711fs*17(1)		breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	ATTCCGTTGCTTTTTTTTTGG	0.502													7	83	---	---	---	---					
LINC01514	101927396	broad.mit.edu	37	10	102941524	102941524	+	RNA	DEL	G	G	-			TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr10:102941524delG	ENST00000434189.2	+	0	545																											TTATCTTTGAGGGTTTTGGAA	0.502													2	4	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25483318	25483319	+	RNA	INS	-	-	G	rs140580374	by1000genomes	TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr15:25483318_25483319insG	ENST00000453082.2	+	0	1979					NR_003343.1																						GCGCATCTTGTGGGGGGGCAAT	0.579													7	10	---	---	---	---					
CLEC17A	388512	broad.mit.edu	37	19	14694175	14694176	+	In_Frame_Ins	INS	-	-	GGA	rs34295949		TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chr19:14694175_14694176insGGA	ENST00000547437.1	+	2	127_128	c.50_51insGGA	c.(49-51)aga>aGGAga	p.17_17R>RR	CLEC17A_ENST00000417570.1_In_Frame_Ins_p.17_17R>RR|CLEC17A_ENST00000397439.2_In_Frame_Ins_p.17_17R>RR	NM_207390.3	NP_997273.3	Q6ZS10	CL17A_HUMAN	C-type lectin domain family 17, member A	17						cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity										GAAGGGACCATGGAGGAGGAGG	0.579													12	13	---	---	---	---					
NUDT11	55190	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	TCCTCGAGGCAGCC	-	rs78182391		TCGA-QT-A5XN-01A-11D-A35D-08	TCGA-QT-A5XN-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e830e5f5-a441-4daf-9431-8bf7f8e604e4	cbc0a7de-9e67-408c-874c-f6827bcc3b14	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	ENST00000375992.3	-	0	139_152					NM_018159.3	NP_060629.2	Q96G61	NUD11_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.?(5)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	9	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.692										HNSCC(48;0.14)			6	12	---	---	---	---