Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC27A6	28965	broad.mit.edu	37	5	128301920	128301920	+	Missense_Mutation	SNP	C	C	A			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr5:128301920C>A	ENST00000262462.4	+	1	1100	c.90C>A	c.(88-90)gaC>gaA	p.D30E	SLC27A6_ENST00000506176.1_Missense_Mutation_p.D30E|SLC27A6_ENST00000395266.1_Missense_Mutation_p.D30E			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	30					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TTTGGGATGACTTCTGGTTCG	0.478000													7	63					2.0095e-06	2.21045e-06	1	1	0
KRTAP10-1	386677	broad.mit.edu	37	21	45959752	45959752	+	Silent	SNP	G	G	A			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr21:45959752G>A	ENST00000400375.1	-	1	326	c.282C>T	c.(280-282)ccC>ccT	p.P94P	TSPEAR_ENST00000397916.1_Intron|TSPEAR_ENST00000323084.4_Intron	NM_198691.2	NP_941964.2	P60331	KR101_HUMAN	keratin associated protein 10-1	94	24 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|central_nervous_system(1)|endometrium(1)|lung(3)|prostate(4)|skin(1)	11						cctgctggcagggggaggagg	0.662000													4	95					0	0	1	0	0
PPEF2	5470	broad.mit.edu	37	4	76787341	76787341	+	Splice_Site	SNP	C	C	T			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr4:76787341C>T	ENST00000286719.7	-	15	2277		c.e15+1			NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2						detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CACACCGTTACCTCGCGACTC	0.473000													36	61					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	15977990	15977990	+	Missense_Mutation	SNP	C	C	T			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr8:15977990C>T	ENST00000262101.5	-	9	1280	c.1159G>A	c.(1159-1161)Gtc>Atc	p.V387I	MSR1_ENST00000350896.3_Intron|MSR1_ENST00000445506.2_Missense_Mutation_p.V405I|MSR1_ENST00000355282.2_Intron			P21757	MSRE_HUMAN	macrophage scavenger receptor 1	387	SRCR.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CTCCTACAGACGACCTGTCCA	0.542000													5	103					0	0	1	0	0
BARHL2	343472	broad.mit.edu	37	1	91180275	91180275	+	Missense_Mutation	SNP	G	G	A			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr1:91180275G>A	ENST00000370445.4	-	2	705	c.664C>T	c.(664-666)Cgt>Tgt	p.R222C		NM_020063.1	NP_064447.1	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	222						nucleus	sequence-specific DNA binding			cervix(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		GGACTCTCACGGCTACTCGTA	0.542000													19	121					0	0	1	0	0
TYW1	55253	broad.mit.edu	37	7	66474575	66474575	+	Silent	SNP	C	C	T			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr7:66474575C>T	ENST00000359626.5	+	4	443	c.279C>T	c.(277-279)ttC>ttT	p.F93F		NM_018264.2	NP_060734.2	Q9NV66	TYW1_HUMAN	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	93	Flavodoxin-like.				tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			breast(1)|endometrium(8)|kidney(10)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(3)|stomach(2)|urinary_tract(2)	46		Lung NSC(55;0.0846)|all_lung(88;0.183)				ATTAGGGATTCGCAACAGTTC	0.398000													4	49					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72081809	72081809	+	RNA	SNP	T	T	C			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr7:72081809T>C	ENST00000438125.1	-	0	1246							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										GAACTTTCTCTGCAGTAGGTA	0.498000													7	88					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49169216	49169216	+	Missense_Mutation	SNP	G	G	A			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr12:49169216G>A	ENST00000307885.4	-	10	2544	c.1850C>T	c.(1849-1851)gCc>gTc	p.A617V	ADCY6_ENST00000552090.1_5'UTR|ADCY6_ENST00000357869.3_Missense_Mutation_p.A617V|ADCY6_ENST00000550422.1_Missense_Mutation_p.A617V	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	617					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						AGGGTTCAGGGCATCTTGGGT	0.572000													3	33					0	0	1	0	0
FLAD1	80308	broad.mit.edu	37	1	154961060	154961060	+	Silent	SNP	A	A	G			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr1:154961060A>G	ENST00000368433.1	+	2	1195	c.852A>G	c.(850-852)ctA>ctG	p.L284L	FLAD1_ENST00000295530.2_Silent_p.L17L|FLAD1_ENST00000315144.10_Silent_p.L187L|FLAD1_ENST00000292180.3_Silent_p.L284L|FLAD1_ENST00000368428.1_5'UTR|FLAD1_ENST00000405236.2_Silent_p.L185L|FLAD1_ENST00000368431.3_Silent_p.L185L|FLAD1_ENST00000368432.1_Silent_p.L187L			Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase 1	284					FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|ovary(3)|skin(3)	22	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CAAAGGAGCTATATGTGGCTG	0.587000													9	25					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43886328	43886328	+	Silent	SNP	G	G	A			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr12:43886328G>A	ENST00000389420.3	-	6	1055	c.1056C>T	c.(1054-1056)gaC>gaT	p.D352D	ADAMTS20_ENST00000553158.1_Silent_p.D352D	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	352	Peptidase M12B.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GAACAGCAGTGTCATGGTGGG	0.383000													3	9					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	64005579	64005579	+	Missense_Mutation	SNP	G	G	A			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr15:64005579G>A	ENST00000443617.2	-	23	4523	c.4436C>T	c.(4435-4437)gCc>gTc	p.A1479V	RP11-317G6.1_ENST00000559303.2_RNA	NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	1479					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						CCCTTCAGAGGCACTTGTTGA	0.448000													4	71					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53241882	53241882	+	Missense_Mutation	SNP	G	G	T			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr12:53241882G>T	ENST00000359499.4	-	2	89	c.78C>A	c.(76-78)aaC>aaA	p.N26K	KRT78_ENST00000304620.4_Missense_Mutation_p.N136K			Q8N1N4	K2C78_HUMAN	keratin 78	136	Gly-rich.|Head.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						CCAGGACCTTGTTCTGCTGCT	0.602000													8	18					1.12685e-05	1.18051e-05	1	1	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													4	58					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4876138	4876138	+	Missense_Mutation	SNP	G	G	A			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr7:4876138G>A	ENST00000399583.3	-	3	821	c.634C>T	c.(634-636)Cgc>Tgc	p.R212C	RADIL_ENST00000538469.1_5'UTR|RADIL_ENST00000536091.1_Missense_Mutation_p.R212C	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	212					cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		ACTGTGCGGCGCAACCGGGGT	0.736000													3	18					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12187475	12187475	+	Missense_Mutation	SNP	C	C	G			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr19:12187475C>G	ENST00000439326.3	+	4	1715	c.1540C>G	c.(1540-1542)Cat>Gat	p.H514D	ZNF844_ENST00000441304.2_3'UTR	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	514					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.H514D(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						AAAGCCTTCACATCTGCCTCA	0.408000													3	42					0	0	1	0	0
PNLIPRP2	5408	broad.mit.edu	37	10	118396277	118396278	+	RNA	INS	-	-	T	rs148140777	by1000genomes	TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr10:118396277_118396278insT	ENST00000537242.1	+	0	962				PNLIPRP2_ENST00000433618.4_RNA|PNLIPRP2_ENST00000298771.7_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		GACAAATTATGGTTTTTTTTTT	0.421													3	4	---	---	---	---					
HERC2P2	400322	broad.mit.edu	37	15	23299147	23299147	+	RNA	DEL	A	A	-			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr15:23299147delA	ENST00000560464.1	-	0	4510																											ACATTCAAAGAAAAAAAAAAA	0.313													6	11	---	---	---	---					
EVPLL	645027	broad.mit.edu	37	17	18284713	18284713	+	Frame_Shift_Del	DEL	G	G	-			TCGA-S7-A7WW-01A-11D-A35I-08	TCGA-S7-A7WW-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	81370641-1947-468a-8a05-58c3dbcdd5ea	1c34dd2e-1a09-41bf-819d-62bc7956e879	g.chr17:18284713delG	ENST00000399134.4	+	3	454	c.96delG	c.(94-96)ctfs	p.L32fs	RP1-37N7.1_ENST00000579352.1_RNA	NM_001145127.1	NP_001138599.1	A8MZ36	EVPLL_HUMAN	envoplakin-like	32										NS(1)|endometrium(1)|large_intestine(1)|lung(2)	5						GCCAGGCCCTGCAGCACCAGC	0.672													2	4	---	---	---	---