Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANKRD36C	400986	broad.mit.edu	37	2	96593016	96593016	+	Missense_Mutation	SNP	C	C	A	rs79307257	by1000genomes	TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr2:96593016C>A	ENST00000456556.1	-	28	1969	c.1885G>T	c.(1885-1887)Gat>Tat	p.D629Y						ankyrin repeat domain 36C									p.D629Y(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GAAACAGAATCTTTCTCATCA	0.318000													8	79					1.06961e-07	1.06961e-07	1	1	0
MICAL2	9645	broad.mit.edu	37	11	12243220	12243220	+	Silent	SNP	C	C	T			TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr11:12243220C>T	ENST00000256194.4	+	10	1524	c.1236C>T	c.(1234-1236)gcC>gcT	p.A412A	MICAL2_ENST00000379612.3_Silent_p.A412A|MICAL2_ENST00000537344.1_Silent_p.A412A|MICAL2_ENST00000527546.1_Silent_p.A412A|MICAL2_ENST00000342902.5_Silent_p.A412A	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	412						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		CAGGCTGTGCCCGTGGCTTCC	0.547000													6	90					0	0	1	0	0
P2RY1	5028	broad.mit.edu	37	3	152554691	152554691	+	Nonstop_Mutation	SNP	T	T	A			TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr3:152554691T>A	ENST00000305097.3	+	1	1956	c.1120T>A	c.(1120-1122)Tga>Aga	p.*374R		NM_002563.3	NP_002554.1	P47900	P2RY1_HUMAN	purinergic receptor P2Y, G-protein coupled, 1	0					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(1)|endometrium(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			TACAAGCCTGTGAAGGCACAA	0.383000													6	19					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41749573	41749573	+	Missense_Mutation	SNP	G	G	A	rs144824336		TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr19:41749573G>A	ENST00000301178.4	+	12	1688	c.1498G>A	c.(1498-1500)Gtg>Atg	p.V500M	AXL_ENST00000359092.3_Missense_Mutation_p.V491M|AXL_ENST00000593513.1_Missense_Mutation_p.V232M	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	500						integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						CAGGTACCGCGTGCGCAAGTC	0.557000													5	132					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593025	96593025	+	Missense_Mutation	SNP	C	C	T	rs75189823	by1000genomes	TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr2:96593025C>T	ENST00000456556.1	-	28	1960	c.1876G>A	c.(1876-1878)Gat>Aat	p.D626N						ankyrin repeat domain 36C									p.D626N(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TCTTTCTCATCACTTGTAGCC	0.318000													8	78					0	0	1	0	0
PRPH2	5961	broad.mit.edu	37	6	42689799	42689799	+	Missense_Mutation	SNP	C	C	T			TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr6:42689799C>T	ENST00000230381.5	-	1	513	c.274G>A	c.(274-276)Gcc>Acc	p.A92T		NM_000322.4	NP_000313.2	P23942	PRPH2_HUMAN	peripherin 2 (retinal degeneration, slow)	92					cell adhesion|visual perception	integral to membrane				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	18	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			TTCCATCTGGCATACTTGGCT	0.547000													16	48					0	0	1	0	0
PIGW	284098	broad.mit.edu	37	17	34894046	34894046	+	Nonsense_Mutation	SNP	C	C	T			TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr17:34894046C>T	ENST00000592983.1	+	2	1676	c.1096C>T	c.(1096-1098)Cga>Tga	p.R366*	PIGW_ENST00000328396.2_Nonsense_Mutation_p.R366*|MYO19_ENST00000590081.1_Intron			Q7Z7B1	PIGW_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class W	366					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	O-acyltransferase activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGCAGTATCTCGAAGAATGGC	0.343000													23	31					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946323	16946323	+	RNA	SNP	C	C	T			TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr1:16946323C>T	ENST00000412962.1	-	0	1196																											GCAGAGGCCACGCCAGGGCTC	0.662000													3	5					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119914730	119914730	+	Missense_Mutation	SNP	C	C	T			TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr7:119914730C>T	ENST00000331113.4	+	1	1009	c.44C>T	c.(43-45)gCg>gTg	p.A15V		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	15	Interaction with KCNIP2.				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					GCAAGGGCAGCGGCTATCGGG	0.602000													12	209					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811117	140811117	+	Silent	SNP	C	C	T	rs62344938		TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr4:140811117C>T	ENST00000509479.2	-	2	2329	c.1473G>A	c.(1471-1473)caG>caA	p.Q491Q	MAML3_ENST00000327122.5_Silent_p.Q335Q|MAML3_ENST00000398940.1_Silent_p.Q30Q	NM_018717.4	NP_061187.2	Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	491	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgttgct	0.547000													3	18					0	0	1	0	0
NAP1L2	4674	broad.mit.edu	37	X	72433372	72433372	+	Silent	SNP	G	G	C			TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chrX:72433372G>C	ENST00000373517.3	-	1	1312	c.957C>G	c.(955-957)ccC>ccG	p.P319P	NAP1L2_ENST00000536638.1_Silent_p.P177P	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	319					nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					TTCCCCTATAGGGATGGGGAT	0.378000													5	59					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276229	186276229	+	Missense_Mutation	SNP	A	A	G			TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr1:186276229A>G	ENST00000445192.2	+	7	1423	c.1378A>G	c.(1378-1380)Aca>Gca	p.T460A	PRG4_ENST00000367486.3_Missense_Mutation_p.T417A|PRG4_ENST00000367483.4_Missense_Mutation_p.T419A|PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367485.4_Missense_Mutation_p.T367A	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	460	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity	p.T460A(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CAAGGAGCCTACACCCACCAC	0.657000													5	116					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44560645	44560645	+	Missense_Mutation	SNP	T	T	C			TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr7:44560645T>C	ENST00000289547.4	-	13	3081	c.3026A>G	c.(3025-3027)cAt>cGt	p.H1009R	NPC1L1_ENST00000381160.3_Missense_Mutation_p.H1009R|NPC1L1_ENST00000546276.1_Missense_Mutation_p.H963R	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	1009					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	AAGATACTTATGGAACTGCTC	0.557000													6	166					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	61					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60886280	60886280	+	Silent	SNP	C	C	T			TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr20:60886280C>T	ENST00000252999.3	-	73	10092	c.10026G>A	c.(10024-10026)caG>caA	p.Q3342Q		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	3342	Laminin G-like 4.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AACCCCCAAACTGGTAGGAGT	0.687000													10	23					0	0	1	0	0
PNLIPRP2	5408	broad.mit.edu	37	10	118396277	118396278	+	RNA	INS	-	-	T	rs148140777	by1000genomes	TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr10:118396277_118396278insT	ENST00000537242.1	+	0	962				PNLIPRP2_ENST00000298771.7_RNA|PNLIPRP2_ENST00000433618.4_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		GACAAATTATGGTTTTTTTTTT	0.421													4	7	---	---	---	---					
TSKU	25987	broad.mit.edu	37	11	76506673	76506675	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr11:76506673_76506675delCTG	ENST00000527881.1	+	2	1039_1041	c.13_15delCTG	c.(13-15)del	p.L9del	TSKU_ENST00000333090.4_In_Frame_Del_p.L9del			Q8WUA8	TSK_HUMAN	tsukushi, small leucine rich proteoglycan	9						extracellular region				NS(1)|large_intestine(4)|lung(6)|urinary_tract(1)	12	Ovarian(111;0.112)					GCCGTGGCCCCTGCTGCTGCTGC	0.616													7	52	---	---	---	---					
HECTD4	283450	broad.mit.edu	37	12	112654134	112654135	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr12:112654134_112654135delTG	ENST00000550722.1	-	48	7383_7384	c.6988_6989delCA	c.(6988-6990)gfs	p.Q2330fs	HECTD4_ENST00000430131.2_Frame_Shift_Del_p.Q2054fs|HECTD4_ENST00000377560.5_Frame_Shift_Del_p.Q2304fs	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		GCTCTTCCACTGTAACAAACTG	0.495													2	4	---	---	---	---					
IL27	246778	broad.mit.edu	37	16	28511175	28511177	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-S7-A7WX-01A-11D-A35I-08	TCGA-S7-A7WX-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6daca770-9655-4159-a5bd-09065d684629	199e0ae8-07df-41ee-b4bb-13464fcac026	g.chr16:28511175_28511177delTCT	ENST00000356897.1	-	5	549_551	c.527_529delAGA	c.(526-531)ggg>g	p.ER176del		NM_145659.3	NP_663634.2	Q8NEV9	IL27A_HUMAN	interleukin 27	176	Glu-rich.				inflammatory response|innate immune response|positive regulation of interferon-gamma biosynthetic process|regulation of defense response to virus|regulation of T cell proliferation|regulation of T-helper 1 cell differentiation	extracellular space	cytokine activity|interleukin-27 receptor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	10						AGCCCCTtcctctcctcctcctc	0.680													4	8	---	---	---	---