Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													5	120					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175375785	175375785	+	Silent	SNP	C	C	T			TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr1:175375785C>T	ENST00000367674.1	-	3	774	c.66G>A	c.(64-66)ctG>ctA	p.L22L	TNR_ENST00000263525.2_Silent_p.L22L	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	22					axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TCATGGAGCCCAGAAGGATCA	0.542000													4	137					0	0	1	0	0
GOLGA8DP	100132979	broad.mit.edu	37	15	22709637	22709637	+	RNA	SNP	T	T	G	rs140467724	by1000genomes	TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr15:22709637T>G	ENST00000314246.8	-	0	1147																											CCCATCTGGTTTTTGAGTTTG	0.547000													3	85					0	0	1	0	0
SON	6651	broad.mit.edu	37	21	34923934	34923934	+	Silent	SNP	T	T	C	rs142825273	by1000genomes	TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr21:34923934T>C	ENST00000356577.4	+	3	2872	c.2397T>C	c.(2395-2397)agT>agC	p.S799S	SON_ENST00000300278.4_Silent_p.S799S|SON_ENST00000381679.4_Silent_p.S799S|SON_ENST00000381692.2_Intron|SON_ENST00000290239.6_Silent_p.S799S	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	799	17 X 10 AA tandem repeats of L-A-[ST]- [NSG]-[TS]-MDSQM.				anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding	p.S799S(4)		breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						TAGCAACCAGTTCCATGGACT	0.507000													5	213					0	0	1	0	0
DSTYK	25778	broad.mit.edu	37	1	205138795	205138795	+	Missense_Mutation	SNP	A	A	G			TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr1:205138795A>G	ENST00000367162.3	-	3	850	c.820T>C	c.(820-822)Ttt>Ctt	p.F274L	DSTYK_ENST00000367160.4_Missense_Mutation_p.F274L|DSTYK_ENST00000367161.3_Missense_Mutation_p.F274L	NM_015375.2	NP_056190.1	Q6XUX3	DUSTY_HUMAN	dual serine/threonine and tyrosine protein kinase	274						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)	14						AATACAGGAAAGGAGAAATAC	0.453000													21	38					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													3	60					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18490305	18490305	+	Missense_Mutation	SNP	T	T	C			TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr8:18490305T>C	ENST00000440756.2	-	11	2336	c.2234A>G	c.(2233-2235)gAg>gGg	p.E745G	PSD3_ENST00000286485.8_Missense_Mutation_p.E209G|PSD3_ENST00000428502.2_Missense_Mutation_p.E72G|PSD3_ENST00000327040.8_Missense_Mutation_p.E743G|PSD3_ENST00000523619.1_Missense_Mutation_p.E678G			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	744					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CTTTTTTTTCTCTTCATCATC	0.358000													19	21					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803552	142803552	+	RNA	SNP	T	T	A	rs141013493	by1000genomes	TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr1:142803552T>A	ENST00000423385.1	-	0	1413																											TCCTGATGAATCTGCAGTCAG	0.269000													5	119					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29625934	29625934	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr20:29625934C>T	ENST00000278882.3	+	5	558	c.178C>T	c.(178-180)Cat>Tat	p.H60Y	FRG1B_ENST00000358464.4_Missense_Mutation_p.H60Y|FRG1B_ENST00000439954.2_Missense_Mutation_p.H65Y																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ACTTGTTGGGCATTCAGATGC	0.338000													8	69					0	0	1	0	0
IGKV2-24	28923	broad.mit.edu	37	2	89476089	89476089	+	RNA	SNP	G	G	A			TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr2:89476089G>A	ENST00000484817.1	-	0	112																											TGAGGAGAGTGGAGTCTGGGT	0.448000													5	69					0	0	1	0	0
LIG1	3978	broad.mit.edu	37	19	48647153	48647153	+	Missense_Mutation	SNP	T	T	C			TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr19:48647153T>C	ENST00000263274.7	-	10	1263	c.844A>G	c.(844-846)Aaa>Gaa	p.K282E	LIG1_ENST00000536218.1_Missense_Mutation_p.K214E|LIG1_ENST00000427526.2_Missense_Mutation_p.K251E	NM_000234.1	NP_000225.1	P18858	DNLI1_HUMAN	ligase I, DNA, ATP-dependent	282					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			breast(1)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(22)|prostate(2)|skin(1)	44		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	TGGCCCGGTTTCCAGCAGGCA	0.532000								Nucleotide excision repair (NER)					26	44					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103027262	103027262	+	Missense_Mutation	SNP	A	A	G			TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr11:103027262A>G	ENST00000375735.2	+	26	4034	c.3890A>G	c.(3889-3891)gAt>gGt	p.D1297G	DYNC2H1_ENST00000398093.3_Missense_Mutation_p.D1297G|DYNC2H1_ENST00000334267.7_Intron	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1297	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GACTGGAAAGATATAGTAAAT	0.343000													24	22					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50208514	50208514	+	Missense_Mutation	SNP	A	A	G			TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr19:50208514A>G	ENST00000392518.4	+	10	1295	c.923A>G	c.(922-924)gAg>gGg	p.E308G	CPT1C_ENST00000405931.2_Missense_Mutation_p.E297G|CPT1C_ENST00000323446.5_Missense_Mutation_p.E308G|CPT1C_ENST00000598293.1_Missense_Mutation_p.E308G|CPT1C_ENST00000354199.5_Missense_Mutation_p.E308G	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	308					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		GCCCAGTACGAGAAGATCTTC	0.562000													36	60					0	0	1	0	0
OR52I1	390037	broad.mit.edu	37	11	4615722	4615722	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr11:4615722G>A	ENST00000450052.2	+	2	526	c.526G>A	c.(526-528)Gtc>Atc	p.V176I	OR52I1_ENST00000530443.2_Missense_Mutation_p.V152I			Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I, member 1	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	15		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAGTATGGCCGTCACCATCAG	0.488000													3	47					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180365982	180365982	+	Silent	SNP	A	A	G			TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr3:180365982A>G	ENST00000273654.4	-	16	2204	c.1585T>C	c.(1585-1587)Ttg>Ctg	p.L529L	CCDC39_ENST00000442201.2_Silent_p.L445L			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	445					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TGCTGCTTCAAGGTTTCAAAA	0.343000													7	15					0	0	1	0	0
CHMP7	91782	broad.mit.edu	37	8	23104385	23104385	+	Frame_Shift_Del	DEL	G	G	-			TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr8:23104385delG	ENST00000397677.1	+	2	825	c.177delG	c.(175-177)ttfs	p.L59fs	CHMP7_ENST00000313219.7_Frame_Shift_Del_p.L59fs	NM_152272.3	NP_689485.1	Q8WUX9	CHMP7_HUMAN	charged multivesicular body protein 7	59					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		GGGCGCCGTTGGTGCTGAGCC	0.667											OREG0018633	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
MIDN	90007	broad.mit.edu	37	19	1254406	1254407	+	Frame_Shift_Ins	INS	-	-	C			TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chr19:1254406_1254407insC	ENST00000300952.2	+	5	1140_1141	c.625_626insC	c.(625-627)cccfs	p.P209fs	MIDN_ENST00000591446.2_Frame_Shift_Ins_p.P209fs	NM_177401.4	NP_796375.3	Q504T8	MIDN_HUMAN	midnolin	209						nucleolus				NS(1)|endometrium(3)|kidney(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACCAGCCCGTCCCCTGCATCT	0.738													2	4	---	---	---	---					
OPN1MW2	728458	broad.mit.edu	37	X	153496178	153496178	+	Frame_Shift_Del	DEL	G	G	-			TCGA-WB-A80Y-01A-11D-A35I-08	TCGA-WB-A80Y-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7962f52f-3c00-4ae6-81fa-eb3dc9bacbf1	36e38cc8-de46-486b-8069-c0b596a0de22	g.chrX:153496178delG	ENST00000369929.4	+	5	966	c.906delG	c.(904-906)ttfs	p.L302fs		NM_001048181.2	NP_001041646.1			opsin 1 (cone pigments), medium-wave-sensitive 2											haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)|stomach(2)|urinary_tract(1)	6	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCCACCCTTTGATGGCTGCCC	0.547													71	82	---	---	---	---