Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													4	171					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25887455	25887455	+	Missense_Mutation	SNP	C	C	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr10:25887455C>A	ENST00000376351.3	+	11	3259	c.2900C>A	c.(2899-2901)cCa>cAa	p.P967Q	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	967						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GCGGAGGAGCCAAGAAAGCCT	0.463000													47	88					5.34276e-22	5.63957e-22	1	1	0
KIF6	221458	broad.mit.edu	37	6	39507801	39507801	+	Silent	SNP	G	G	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr6:39507801G>A	ENST00000287152.7	-	13	1717	c.1623C>T	c.(1621-1623)tcC>tcT	p.S541S	KIF6_ENST00000373213.4_Silent_p.S380S|KIF6_ENST00000373215.3_Silent_p.S541S|KIF6_ENST00000373216.3_Silent_p.S541S|KIF6_ENST00000538893.1_Intron	NM_145027.4	NP_659464.3	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	541					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(16)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GGAGCAAACTGGATCTTTTCC	0.448000													46	89					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20975444	20975444	+	Silent	SNP	C	C	T			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr16:20975444C>T	ENST00000261383.3	-	53	9761	c.9762G>A	c.(9760-9762)ctG>ctA	p.L3254L	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3254	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TTTCATCCTCCAGGATGTTAC	0.438000													75	96					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93017508	93017508	+	Silent	SNP	C	C	G			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr8:93017508C>G	ENST00000523629.1	-	6	1030	c.576G>C	c.(574-576)ctG>ctC	p.L192L	RUNX1T1_ENST00000422361.2_Silent_p.L155L|RUNX1T1_ENST00000518844.1_Silent_p.L165L|RUNX1T1_ENST00000360348.2_Silent_p.L155L|RUNX1T1_ENST00000520724.1_Silent_p.L155L|RUNX1T1_ENST00000436581.2_Silent_p.L203L|RUNX1T1_ENST00000396218.1_Silent_p.L165L|RUNX1T1_ENST00000265814.3_Silent_p.L192L|RUNX1T1_ENST00000521553.1_Silent_p.L155L	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	192	TAFH.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GCTCACGCTGCAGCAGGGGCA	0.552000													5	26					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10465053	10465053	+	Silent	SNP	T	T	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr8:10465053T>A	ENST00000382483.3	-	4	6778	c.6555A>T	c.(6553-6555)gcA>gcT	p.A2185A		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	2185					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCTCCCCTTCTGCCTCTGGGG	0.607000													4	128					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547093	132547093	+	Silent	SNP	A	A	G	rs60608267	by1000genomes	TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr12:132547093A>G	ENST00000333577.4	+	48	8398	c.8289A>G	c.(8287-8289)caA>caG	p.Q2763Q	EP400_ENST00000389561.2_Silent_p.Q2727Q|EP400_ENST00000330386.6_Silent_p.Q2646Q|EP400_ENST00000332482.4_Silent_p.Q2690Q|EP400_ENST00000389562.2_Silent_p.Q2726Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2726Q(9)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagc	0.567000													3	48					0	0	1	0	0
PCDHB1	0	broad.mit.edu	37	5	140431407	140431407	+	Missense_Mutation	SNP	C	C	T			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr5:140431407C>T	ENST00000306549.3	+	1	429	c.352C>T	c.(352-354)Cgg>Tgg	p.R118W		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		118	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGTCCTTCCGGGCCGAGGT	0.517000													15	40					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53663407	53663407	+	Silent	SNP	C	C	T			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr12:53663407C>T	ENST00000257934.4	+	3	772	c.681C>T	c.(679-681)caC>caT	p.H227H	ESPL1_ENST00000552462.1_Silent_p.H227H	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	227					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						TCTCCAGGCACGTGATCAGAG	0.567000													6	256					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123779761	123779761	+	Missense_Mutation	SNP	T	T	C			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr9:123779761T>C	ENST00000223642.1	-	14	1774	c.1745A>G	c.(1744-1746)tAt>tGt	p.Y582C		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	582					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	GCCTGGAGAATATGCATCTGC	0.413000													22	25					0	0	1	0	0
KCNJ4	3761	broad.mit.edu	37	22	38824098	38824098	+	Missense_Mutation	SNP	G	G	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr22:38824098G>A	ENST00000303592.3	-	2	298	c.40C>T	c.(40-42)Cgg>Tgg	p.R14W		NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	14					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					CGCTTCCGCCGGGGCACGTGG	0.642000													8	346					0	0	1	0	0
OLFML1	283298	broad.mit.edu	37	11	7531065	7531065	+	Silent	SNP	G	G	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr11:7531065G>A	ENST00000329293.3	+	3	1249	c.855G>A	c.(853-855)ggG>ggA	p.G285G	CTD-2516F10.2_ENST00000530201.1_RNA|OLFML1_ENST00000528758.1_3'UTR|OLFML1_ENST00000530135.1_Silent_p.G285G	NM_198474.3	NP_940876.2	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1	285	Olfactomedin-like.					extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(3)|prostate(2)	24				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		TCCACTCTGGGCCAGGCACCC	0.572000													3	38					0	0	1	0	0
SYNPO	11346	broad.mit.edu	37	5	150027814	150027814	+	Missense_Mutation	SNP	G	G	A	rs78583075	by1000genomes	TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr5:150027814G>A	ENST00000394243.1	+	3	1083	c.709G>A	c.(709-711)Gac>Aac	p.D237N	SYNPO_ENST00000518872.1_Intron|SYNPO_ENST00000307662.4_5'UTR|SYNPO_ENST00000519664.1_5'UTR|SYNPO_ENST00000522122.1_Missense_Mutation_p.D237N	NM_001166208.1	NP_001159680.1	Q8N3V7	SYNPO_HUMAN	synaptopodin	237					positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			NS(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(4)|prostate(1)|urinary_tract(2)	18		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAGAGCCCCGACAGAGGGGT	0.672000													11	18					0	0	1	0	0
PRSS1	5644	broad.mit.edu	37	7	142459851	142459851	+	Missense_Mutation	SNP	G	G	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr7:142459851G>A	ENST00000486171.1	+	4	486	c.469G>A	c.(469-471)Ggc>Agc	p.G157S	PRSS1_ENST00000311737.7_Missense_Mutation_p.G143S			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	143	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			CCTCATCTCTGGCTGGGGCAA	0.567000													11	44					0	0	1	0	0
LIG3	3980	broad.mit.edu	37	17	33310098	33310098	+	Missense_Mutation	SNP	G	G	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr17:33310098G>A	ENST00000378526.4	+	2	207	c.74G>A	c.(73-75)cGa>cAa	p.R25Q	LIG3_ENST00000586407.1_Intron|LIG3_ENST00000262327.5_Missense_Mutation_p.R25Q	NM_013975.3	NP_039269.2	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent	25					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			endometrium(4)|large_intestine(8)|lung(9)|ovary(3)|pancreas(2)|prostate(1)|skin(3)|stomach(1)	31		Ovarian(249;0.17)			Bleomycin(DB00290)	TGCCTATTCCGAAAACATCAC	0.463000								Other BER factors					18	39					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111130444	111130444	+	Silent	SNP	G	G	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr13:111130444G>A	ENST00000360467.5	+	30	2826	c.2520G>A	c.(2518-2520)ctG>ctA	p.L840L		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	840	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CTCCAGGACTGCATGGATTCC	0.662000													3	19					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237972270	237972270	+	Nonsense_Mutation	SNP	C	C	T			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr1:237972270C>T	ENST00000366574.2	+	100	14685	c.14368C>T	c.(14368-14370)Cga>Tga	p.R4790*	RYR2_ENST00000542537.1_Nonsense_Mutation_p.R4774*|RYR2_ENST00000360064.6_Nonsense_Mutation_p.R4796*	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4790					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.R4788R(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAATTTTTTCCGAAAATTCTA	0.353000													68	88					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427759	3427759	+	RNA	SNP	C	C	T			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr11:3427759C>T	ENST00000529482.1	+	0	876																											TGTCTGCACACGTCCTGCAGT	0.612000													3	28					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86087985	86087985	+	Missense_Mutation	SNP	G	G	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr14:86087985G>A	ENST00000330753.4	+	2	894	c.127G>A	c.(127-129)Gac>Aac	p.D43N	FLRT2_ENST00000554746.1_Missense_Mutation_p.D43N	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	43	LRRNT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity	p.D43N(2)		NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GTGCCGCTGCGACAGGAACTT	0.522000													17	105					0	0	1	0	0
PCDH12	51294	broad.mit.edu	37	5	141335501	141335501	+	Missense_Mutation	SNP	C	C	T			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr5:141335501C>T	ENST00000231484.3	-	1	3126	c.1916G>A	c.(1915-1917)cGc>cAc	p.R639H		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	639	Cadherin 6.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTTCCACTGCGGATGCTGTA	0.567000													15	34					0	0	1	0	0
DRD5	0	broad.mit.edu	37	4	9784028	9784028	+	Silent	SNP	T	T	C	rs2227841	byFrequency	TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr4:9784028T>C	ENST00000304374.2	+	1	771	c.375T>C	c.(373-375)acT>acC	p.T125T		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	125					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	TGTGCTCCACTGCCTCCATCC	0.622000													4	43					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17697096	17697096	+	Missense_Mutation	SNP	G	G	C	rs113303801		TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr17:17697096G>C	ENST00000353383.1	+	3	1303	c.834G>C	c.(832-834)caG>caC	p.Q278H	RAI1_ENST00000261641.6_Missense_Mutation_p.Q278H	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	278	Gln-rich.|Poly-Gln.					cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		GCTATGACcagcagcagcagc	0.637000													3	29					0	0	1	0	0
AZU1	566	broad.mit.edu	37	19	829580	829580	+	Silent	SNP	C	C	T			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr19:829580C>T	ENST00000233997.2	+	3	255	c.234C>T	c.(232-234)acC>acT	p.T78T		NM_001700.3	NP_001691.1	P20160	CAP7_HUMAN	azurocidin 1	78	Hydrophobic.|Peptidase S1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cellular extravasation|defense response to Gram-negative bacterium|glial cell migration|induction of positive chemotaxis|inflammatory response|macrophage chemotaxis|microglial cell activation|monocyte activation|positive regulation of cell adhesion|positive regulation of fractalkine biosynthetic process|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of phagocytosis|positive regulation of tumor necrosis factor biosynthetic process|proteolysis|regulation of vascular permeability	azurophil granule|extracellular region	heparin binding|serine-type endopeptidase activity|toxin binding			NS(1)|endometrium(1)|kidney(1)|lung(4)|pancreas(1)|upper_aerodigestive_tract(2)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGTTAGCACCGTGGTGCTGG	0.637000													18	116					0	0	1	0	0
BANK1	55024	broad.mit.edu	37	4	102981512	102981512	+	Missense_Mutation	SNP	A	A	C			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr4:102981512A>C	ENST00000504592.1	+	16	2487	c.2069A>C	c.(2068-2070)cAg>cCg	p.Q690P	BANK1_ENST00000508653.1_Missense_Mutation_p.Q572P|BANK1_ENST00000444316.2_Missense_Mutation_p.Q675P|BANK1_ENST00000428908.1_Missense_Mutation_p.Q572P|BANK1_ENST00000322953.4_Missense_Mutation_p.Q705P			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	705					B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		AAACACTGGCAGATGGGAAAA	0.433000													24	37					0	0	1	0	0
PSME4	23198	broad.mit.edu	37	2	54114534	54114534	+	Missense_Mutation	SNP	G	G	C			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr2:54114534G>C	ENST00000404125.1	-	40	4646	c.4591C>G	c.(4591-4593)Cct>Gct	p.P1531A	PSME4_ENST00000421748.2_Missense_Mutation_p.P675A	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	1531					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GTAAACTCAGGGACATGAGGC	0.373000													8	52					0	0	1	0	0
NETO2	81831	broad.mit.edu	37	16	47143592	47143592	+	Missense_Mutation	SNP	C	C	T			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr16:47143592C>T	ENST00000562435.1	-	7	1069	c.685G>A	c.(685-687)Gag>Aag	p.E229K	NETO2_ENST00000303155.5_Missense_Mutation_p.E222K	NM_018092.4	NP_060562.3	Q8NC67	NETO2_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 2	229	CUB 2.					integral to membrane	receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	29		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				TTTGAGTGCTCCATTTGATAA	0.323000										HNSCC(25;0.065)			29	44					0	0	1	0	0
AMZ2P1	0	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													7	102					0	0	1	0	0
GAS7	8522	broad.mit.edu	37	17	9843494	9843494	+	Missense_Mutation	SNP	G	G	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr17:9843494G>A	ENST00000396115.1	-	8	885	c.575C>T	c.(574-576)gCg>gTg	p.A192V	GAS7_ENST00000540214.1_Intron|GAS7_ENST00000323816.4_Missense_Mutation_p.A188V|GAS7_ENST00000583882.1_Intron|GAS7_ENST00000432992.2_Missense_Mutation_p.A252V|GAS7_ENST00000585266.1_Missense_Mutation_p.A188V|GAS7_ENST00000542249.1_Missense_Mutation_p.A197V|GAS7_ENST00000437099.2_Missense_Mutation_p.A188V|GAS7_ENST00000580865.1_Missense_Mutation_p.A112V|GAS7_ENST00000579158.1_Missense_Mutation_p.A204V	NM_201432.1	NP_958836.1	O60861	GAS7_HUMAN	growth arrest-specific 7	252					cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(7)|lung(18)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	39						TAAGTTCTTCGCATAGTCTTC	0.537000			T	MLL	AML*								5	194					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887612	12887612	+	Missense_Mutation	SNP	T	T	C	rs60558629		TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr1:12887612T>C	ENST00000535591.1	-	3	440	c.245A>G	c.(244-246)cAt>cGt	p.H82R		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	82								p.H82R(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GAAGCACCCATGGGCCATAGC	0.488000													5	117					0	0	1	0	0
MUC13	56667	broad.mit.edu	37	3	124627149	124627149	+	Missense_Mutation	SNP	C	C	T	rs75643991		TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr3:124627149C>T	ENST00000311075.3	-	11	1419	c.1381G>A	c.(1381-1383)Gaa>Aaa	p.E461K		NM_033049.3	NP_149038.3	Q9H3R2	MUC13_HUMAN	mucin 13, cell surface associated	461						extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(1)|stomach(1)	18						TGAAAGTCTTCGTCAATCAAG	0.413000													16	59					0	0	1	0	0
SLC4A2	6522	broad.mit.edu	37	7	150773114	150773114	+	Silent	SNP	T	T	C			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr7:150773114T>C	ENST00000485713.1	+	22	4526	c.3486T>C	c.(3484-3486)cgT>cgC	p.R1162R	SLC4A2_ENST00000310317.5_Silent_p.R1080R|RP11-148K1.12_ENST00000485974.1_RNA|SLC4A2_ENST00000392826.2_Silent_p.R1153R|SLC4A2_ENST00000413384.2_Silent_p.R1162R|SLC4A2_ENST00000461735.1_Silent_p.R1148R	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	1162	Membrane (anion exchange).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGACCCTCCGTATGCACCTGT	0.652000													19	27					0	0	1	0	0
YTHDC2	64848	broad.mit.edu	37	5	112878169	112878169	+	Silent	SNP	C	C	T			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr5:112878169C>T	ENST00000161863.4	+	10	1677	c.1464C>T	c.(1462-1464)gtC>gtT	p.V488V	YTHDC2_ENST00000515883.1_Silent_p.V488V	NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	488							ATP binding|ATP-dependent helicase activity|nucleic acid binding	p.V488V(1)		NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		TTGCTCAGGTCTTTCATCTCA	0.294000													20	73					0	0	1	0	0
ANGPTL5	253935	broad.mit.edu	37	11	101765741	101765741	+	Missense_Mutation	SNP	G	G	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr11:101765741G>A	ENST00000334289.3	-	8	1311	c.716C>T	c.(715-717)aCc>aTc	p.T239I		NM_178127.4	NP_835228.2	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5	239	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(2)|skin(3)	29		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		CATAAAACTGGTATTTTTCTG	0.274000													9	43					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	45					0	0	1	0	0
ZSCAN25	221785	broad.mit.edu	37	7	99217449	99217449	+	Missense_Mutation	SNP	G	G	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr7:99217449G>A	ENST00000394152.2	+	4	547	c.220G>A	c.(220-222)Gag>Aag	p.E74K	ZSCAN25_ENST00000262941.6_Missense_Mutation_p.E74K|ZSCAN25_ENST00000466948.1_3'UTR|ZSCAN25_ENST00000334715.3_Missense_Mutation_p.E74K	NM_145115.2	NP_660090.2			zinc finger and SCAN domain containing 25																		GCTGAGGCCCGAGTTGCACAC	0.627000													37	75					0	0	1	0	0
GBP6	163351	broad.mit.edu	37	1	89844044	89844044	+	Missense_Mutation	SNP	C	C	T			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr1:89844044C>T	ENST00000370456.4	+	5	590	c.497C>T	c.(496-498)tCc>tTc	p.S166F	GBP6_ENST00000535065.1_Missense_Mutation_p.S36F	NM_198460.2	NP_940862.2	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	166							GTP binding|GTPase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		GTAGAAGATTCCACAGAGTTT	0.453000													22	80					0	0	1	0	0
ADH6	130	broad.mit.edu	37	4	100126203	100126203	+	Missense_Mutation	SNP	G	G	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr4:100126203G>A	ENST00000394899.2	-	8	1075	c.982C>T	c.(982-984)Cac>Tac	p.H328Y	RP11-696N14.1_ENST00000500358.2_RNA|RP11-696N14.1_ENST00000506454.1_RNA|ADH6_ENST00000407820.2_Missense_Mutation_p.H119Y|ADH6_ENST00000394897.1_Silent_p.S282S|RP11-696N14.1_ENST00000506160.1_RNA|ADH6_ENST00000237653.7_Missense_Mutation_p.H328Y	NM_001102470.1	NP_001095940.1	P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	328					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	TTAGGGATGTGCTGTCTGCTC	0.363000													4	106					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53945837	53945837	+	RNA	SNP	T	T	C	rs17855120	by1000genomes	TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr19:53945837T>C	ENST00000454407.1	+	0	55				TPM3P9_ENST00000424846.3_RNA			Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		GGACCAGACTTTGCTTGACCT	0.512000													3	27					0	0	1	0	0
SCP2	6342	broad.mit.edu	37	1	53453802	53453802	+	Missense_Mutation	SNP	G	G	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr1:53453802G>A	ENST00000371514.3	+	11	1243	c.1075G>A	c.(1075-1077)Gct>Act	p.A359T	SCP2_ENST00000528311.1_Missense_Mutation_p.A278T|SCP2_ENST00000407246.2_Missense_Mutation_p.A335T|SCP2_ENST00000371509.4_Missense_Mutation_p.A315T|SCP2_ENST00000371513.5_Missense_Mutation_p.A315T	NM_002979.4	NP_002970.2	P22307	NLTP_HUMAN	sterol carrier protein 2	359					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	15						CCCACTAGGCGCTACAGGTAA	0.368000													15	18					0	0	1	0	0
LINC00969	0	broad.mit.edu	37	3	195400795	195400795	+	RNA	SNP	C	C	T	rs7615357	by1000genomes	TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr3:195400795C>T	ENST00000445430.1	+	0	1391																											GGGGCAAACTCGCTGTTGGAC	0.592000													3	38					0	0	1	0	0
OR4K15	81127	broad.mit.edu	37	14	20444489	20444489	+	Missense_Mutation	SNP	T	T	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr14:20444489T>A	ENST00000305051.5	+	1	887	c.812T>A	c.(811-813)gTc>gAc	p.V271D		NM_001005486.1	NP_001005486.1	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K, member 15	271					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|ovary(1)|prostate(2)|skin(1)|stomach(1)	39	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATCACTGTGGTCACTTTATTC	0.458000													24	53					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129911740	129911740	+	Missense_Mutation	SNP	C	C	A			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr10:129911740C>A	ENST00000368654.3	-	8	1982	c.1607G>T	c.(1606-1608)aGa>aTa	p.R536I	MKI67_ENST00000368653.3_Missense_Mutation_p.R176I	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	536					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CAGAGACTTTCTTTTGGTTGG	0.498000													6	205					0.00116845	0.00116845	1	1	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664240	22664240	+	RNA	SNP	T	T	G			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr22:22664240T>G	ENST00000426066.1	+	0	763					NR_027293.1																						GATAAGCTGCTGATGAGCGGT	0.532000													3	53					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167420005	167420005	+	Missense_Mutation	SNP	C	C	T			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr5:167420005C>T	ENST00000519204.1	+	4	759	c.641C>T	c.(640-642)cCg>cTg	p.P214L	TENM2_ENST00000520393.1_3'UTR|TENM2_ENST00000545108.1_Missense_Mutation_p.P335L|TENM2_ENST00000403607.2_Missense_Mutation_p.P168L|TENM2_ENST00000518659.1_Missense_Mutation_p.P335L|TENM2_ENST00000520394.1_Missense_Mutation_p.P144L					teneurin transmembrane protein 2																		AGCTCTTCCCCGGGATACCCT	0.577000													6	62					0	0	1	0	0
MGST1	4257	broad.mit.edu	37	12	16516847	16516847	+	Missense_Mutation	SNP	C	C	T			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr12:16516847C>T	ENST00000396209.1	+	4	483	c.340C>T	c.(340-342)Cgg>Tgg	p.R114W	MGST1_ENST00000396207.1_Missense_Mutation_p.R114W|MGST1_ENST00000535309.1_Intron|MGST1_ENST00000010404.2_Missense_Mutation_p.R114W|MGST1_ENST00000396210.3_Missense_Mutation_p.R114W|MGST1_ENST00000540056.1_3'UTR	NM_145791.2	NP_665734.1	P10620	MGST1_HUMAN	microsomal glutathione S-transferase 1	114					protein homotrimerization|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane	glutathione transferase activity	p.R114W(1)		endometrium(2)|large_intestine(2)|lung(4)|ovary(1)	9		Hepatocellular(102;0.121)			Glutathione(DB00143)	TGTCGGAGCACGGATCTACCA	0.448000													8	179					0	0	1	0	0
KRTAP4-5	85289	broad.mit.edu	37	17	39305619	39305619	+	Missense_Mutation	SNP	G	G	T			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr17:39305619G>T	ENST00000343246.4	-	1	435	c.401C>A	c.(400-402)tCt>tAt	p.S134Y		NM_033188.3	NP_149445.3	Q9BYR2	KRA45_HUMAN	keratin associated protein 4-5	139	27 X 5 AA repeats of C-C-[GRQVCHIEK]- [SPTR]-[VSTQYC].					keratin filament		p.S134Y(2)		central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(4)	6		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ttcacagcaagaggggtggca	0.637000													3	15					0.00024832	0.000252754	1	1	0
DAXX	1616	broad.mit.edu	37	6	33287453	33287453	+	Frame_Shift_Del	DEL	A	A	-			TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr6:33287453delA	ENST00000374542.5	-	6	1848	c.1644delT	c.(1642-1644)aafs	p.N548fs	DAXX_ENST00000266000.6_Frame_Shift_Del_p.N548fs|DAXX_ENST00000477162.1_5'UTR|DAXX_ENST00000414083.2_Frame_Shift_Del_p.N473fs	NM_001141969.1|NM_001141970.1|NM_001350.4	NP_001135441.1|NP_001135442.1|NP_001341.1	Q9UER7	DAXX_HUMAN	death-domain associated protein	548	Asp/Glu-rich (acidic).|Interaction with MAP3K5.|Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(2)|lung(7)|ovary(3)|pancreas(18)|prostate(3)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	55						GCTGTTCTCCATTGCTTTCAG	0.532			"""Mis, F, N"""		Pancreatic neuroendocrine tumors. Paediatric GBM								35	103	---	---	---	---					
PMS2P4	0	broad.mit.edu	37	7	66762433	66762433	+	RNA	DEL	A	A	-	rs68053451		TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr7:66762433delA	ENST00000414507.1	-	0	184																											tctcaaaaagaaaaaaaaaaa	0.408													3	4	---	---	---	---					
FTH1	2495	broad.mit.edu	37	11	61727341	61727343	+	In_Frame_Del	DEL	CTT	CTT	-	rs62640560		TCGA-2A-AAYU-01A-11D-A41K-08	TCGA-2A-AAYU-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3333fa05-d0eb-46bb-91af-2492f5b84e23	1695b0a1-b764-4797-83d5-4fcfed8fb4a7	g.chr11:61727341_61727343delCTT	ENST00000529191.1	-	2	376_378	c.171_173delAAG	c.(169-174)agt>ag	p.RS57del	BEST1_ENST00000378043.4_Intron|BEST1_ENST00000301774.9_Intron|BEST1_ENST00000378042.3_Intron|BEST1_ENST00000534553.1_Intron|BEST1_ENST00000449131.2_Intron|FTH1_ENST00000529631.1_In_Frame_Del_p.K50del|BEST1_ENST00000526988.1_Intron|BEST1_ENST00000435278.2_Intron			P02794	FRIH_HUMAN	ferritin, heavy polypeptide 1	0	Ferritin-like diiron.				cell proliferation|cellular membrane organization|immune response|intracellular sequestering of iron ion|iron ion transport|negative regulation of cell proliferation|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|ferroxidase activity|protein binding			NS(2)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8					Iron Dextran(DB00893)	TTCTGTGGGACTTCTTCTGTCCC	0.557													14	14	---	---	---	---