Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													4	85					0	0	1	0	0
MYOC	4653	broad.mit.edu	37	1	171605566	171605566	+	Silent	SNP	G	G	A			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr1:171605566G>A	ENST00000037502.5	-	3	1073	c.1014C>T	c.(1012-1014)ggC>ggT	p.G338G		NM_000261.1	NP_000252.1	Q99972	MYOC_HUMAN	myocilin, trabecular meshwork inducible glucocorticoid response	338	Olfactomedin-like.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(1)|urinary_tract(2)	28	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TGGACTCAGCGCCCTGGAAAT	0.532000													7	50					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168099562	168099562	+	Missense_Mutation	SNP	C	C	G			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr2:168099562C>G	ENST00000409195.1	+	9	1749	c.1660C>G	c.(1660-1662)Caa>Gaa	p.Q554E	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.Q332E|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.Q554E|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	379					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TGACAGTTCTCAAAAAGATCT	0.398000													5	49					0	0	1	0	0
AC024560.3	0	broad.mit.edu	37	3	197348668	197348668	+	RNA	SNP	C	C	G	rs79940815	by1000genomes	TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr3:197348668C>G	ENST00000418868.1	-	0	591					NR_003266.2																						ACTTGAGGCTCTGTCCACCAA	0.488000													4	118					0	0	1	0	0
PTPN21	11099	broad.mit.edu	37	14	88945894	88945894	+	Silent	SNP	C	C	T	rs138744802	byFrequency	TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr14:88945894C>T	ENST00000556564.1	-	13	2165	c.1881G>A	c.(1879-1881)gcG>gcA	p.A627A	PTPN21_ENST00000328736.3_Silent_p.A627A	NM_007039.3	NP_008970.2	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type 21	627						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|liver(1)|lung(7)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						GCGCGTGGCGCGCGGCGGTGA	0.706000													3	29					0	0	1	0	0
NAT10	55226	broad.mit.edu	37	11	34162694	34162694	+	Missense_Mutation	SNP	T	T	C			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr11:34162694T>C	ENST00000257829.3	+	25	2857	c.2651T>C	c.(2650-2652)aTt>aCt	p.I884T	NAT10_ENST00000531159.2_Missense_Mutation_p.I812T|NAT10_ENST00000527971.1_Intron	NM_024662.2	NP_078938.2	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 (GCN5-related)	884	Required for localization to the nucleolus and midbody.					nucleolus	ATP binding|N-acetyltransferase activity|protein binding			endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				GAAAAGGAGATTGAGCTGCCC	0.542000													7	210					0	0	1	0	0
ZNF733P	0	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	28					0	0	1	0	0
TGOLN2	10618	broad.mit.edu	37	2	85554633	85554633	+	Silent	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr2:85554633C>T	ENST00000377386.3	-	2	684	c.222G>A	c.(220-222)gcG>gcA	p.A74A	TGOLN2_ENST00000282120.2_Intron|TGOLN2_ENST00000398263.2_Silent_p.A74A|TGOLN2_ENST00000444342.2_Silent_p.A74A|TGOLN2_ENST00000409232.3_Silent_p.A74A|TGOLN2_ENST00000409015.1_Silent_p.A74A			O43493	TGON2_HUMAN	trans-golgi network protein 2	74	14 X 14 AA tandem repeats.			A -> P (in Ref. 4; BAD96783).		integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding										CTGGGGTCTGCGCCTCCGCAC	0.607000													5	272					0	0	1	0	0
TVP23B	51030	broad.mit.edu	37	17	18708852	18708852	+	Splice_Site	SNP	A	A	G	rs2589696		TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr17:18708852A>G	ENST00000476139.1	+	7	1815		c.e7-1		TVP23B_ENST00000581733.1_Splice_Site|TVP23B_ENST00000307767.8_Splice_Site					trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)																		TGTCTTTTGCAGAACACTGGA	0.368000													4	74					0	0	1	0	0
TAF3	83860	broad.mit.edu	37	10	8006929	8006929	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr10:8006929C>T	ENST00000344293.5	+	3	1662	c.1456C>T	c.(1456-1458)Ccc>Tcc	p.P486S		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	486					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						TTCAAATATGCCCCCCAACTT	0.488000													4	104					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203013195	203013195	+	Missense_Mutation	SNP	T	T	A			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr1:203013195T>A	ENST00000367240.2	+	4	1000	c.473T>A	c.(472-474)tTt>tAt	p.F158Y	PPFIA4_ENST00000447715.2_Missense_Mutation_p.F158Y|PPFIA4_ENST00000295706.4_5'UTR			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						AAGTCACTGTTTGAGCACCAC	0.627000													3	21					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102292953	102292953	+	RNA	SNP	T	T	C			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr15:102292953T>C	ENST00000561463.1	+	0	999																											GGCACAGCGGTGCGACGAGAT	0.587000													5	7					0	0	1	0	0
UBQLN1	29979	broad.mit.edu	37	9	86293436	86293436	+	Missense_Mutation	SNP	T	T	G			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr9:86293436T>G	ENST00000376395.4	-	5	1313	c.790A>C	c.(790-792)Agc>Cgc	p.S264R	UBQLN1_ENST00000257468.7_Missense_Mutation_p.S264R	NM_013438.4|NM_053067.2	NP_038466.2|NP_444295.1	Q9UMX0	UBQL1_HUMAN	ubiquilin 1	264					apoptosis|regulation of protein ubiquitination|response to hypoxia	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm|proteasome complex	kinase binding			breast(4)|endometrium(2)|kidney(4)|large_intestine(6)|lung(10)|prostate(1)	27						CCTGGGATGCTTTCTAGGTTG	0.473000													12	417					0	0	1	0	0
C1orf127	148345	broad.mit.edu	37	1	11015082	11015082	+	Missense_Mutation	SNP	C	C	A			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr1:11015082C>A	ENST00000377004.4	-	9	939	c.940G>T	c.(940-942)Gtc>Ttc	p.V314F	C1orf127_ENST00000377008.4_Missense_Mutation_p.V147F	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	165										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		GGAATGCTGACCACCACAAAG	0.557000													4	60					0.00909568	0.00941483	1	1	0
ACE	1636	broad.mit.edu	37	17	61566347	61566347	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr17:61566347C>T	ENST00000577647.1	+	6	818	c.773C>T	c.(772-774)cCa>cTa	p.P258L	ACE_ENST00000413513.3_Missense_Mutation_p.P258L|ACE_ENST00000428043.1_Missense_Mutation_p.P832L|ACE_ENST00000490216.2_Missense_Mutation_p.P258L|ACE_ENST00000421982.2_Intron|ACE_ENST00000290863.6_Missense_Mutation_p.P258L|ACE_ENST00000290866.4_Missense_Mutation_p.P832L			P12821	ACE_HUMAN	angiotensin I converting enzyme	832	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TACGAGACACCATCCCTGGAG	0.612000													8	31					0	0	1	0	0
TEX264	51368	broad.mit.edu	37	3	51708534	51708534	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr3:51708534C>T	ENST00000415259.1	+	2	1295	c.214C>T	c.(214-216)Ccc>Tcc	p.P72S	TEX264_ENST00000395057.1_Missense_Mutation_p.P72S|TEX264_ENST00000416589.1_Missense_Mutation_p.P72S|TEX264_ENST00000457573.1_Missense_Mutation_p.P72S|TEX264_ENST00000341333.5_Missense_Mutation_p.P72S			Q9Y6I9	TX264_HUMAN	testis expressed 264	72						extracellular region				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(193;8.53e-05)|Kidney(197;0.000594)|KIRC - Kidney renal clear cell carcinoma(197;0.000759)		CAGCATCTCTCCCAAGCTCCG	0.597000													5	39					0	0	1	0	0
NXPE3	91775	broad.mit.edu	37	3	101520287	101520287	+	Missense_Mutation	SNP	C	C	G			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr3:101520287C>G	ENST00000422132.1	+	2	499	c.302C>G	c.(301-303)aCt>aGt	p.T101S	NXPE3_ENST00000491511.1_Missense_Mutation_p.T101S|NXPE3_ENST00000273347.5_Missense_Mutation_p.T101S|NXPE3_ENST00000477909.1_Missense_Mutation_p.T101S					neurexophilin and PC-esterase domain family, member 3																		GTGAAGAGCACTGACCCTTCT	0.552000													8	95					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167182089	167182089	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr5:167182089G>A	ENST00000519204.1	+	1	149	c.31G>A	c.(31-33)Gtt>Att	p.V11I	TENM2_ENST00000520394.1_Missense_Mutation_p.V11I|TENM2_ENST00000518659.1_Intron|TENM2_ENST00000545108.1_Intron|TENM2_ENST00000520393.1_Intron					teneurin transmembrane protein 2																		GATCATTAGCGTTGCTGGCAC	0.507000													4	133					0	0	1	0	0
PRDM8	56978	broad.mit.edu	37	4	81123237	81123237	+	Silent	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr4:81123237C>T	ENST00000339711.4	+	10	1852	c.621C>T	c.(619-621)ggC>ggT	p.G207G	PRDM8_ENST00000504452.1_Silent_p.G207G|PRDM8_ENST00000415738.2_Silent_p.G207G	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	207	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						gcggcggcggcggtggcaaag	0.657000											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	42					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64936221	64936221	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr10:64936221G>A	ENST00000399262.2	-	24	7455	c.7237C>T	c.(7237-7239)Caa>Taa	p.Q2413*	JMJD1C_ENST00000542921.1_Nonsense_Mutation_p.Q2231*|JMJD1C_ENST00000399251.1_3'UTR|JMJD1C_ENST00000402544.1_Nonsense_Mutation_p.Q2176*	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	2413	JmjC.				blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					TCAAGGCCTTGTTCTTTTGAA	0.333000													4	48					0	0	1	0	0
AC024560.3	0	broad.mit.edu	37	3	197348646	197348646	+	RNA	SNP	T	T	C	rs138265355	by1000genomes	TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr3:197348646T>C	ENST00000418868.1	-	0	613					NR_003266.2																						TGGGCCTGCCTGCCCTTTCCA	0.532000													4	101					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56815178	56815178	+	Missense_Mutation	SNP	T	T	C	rs78697874		TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr12:56815178T>C	ENST00000229201.4	-	23	2976	c.2822A>G	c.(2821-2823)gAg>gGg	p.E941G	TIMELESS_ENST00000554616.1_Missense_Mutation_p.E439G|TIMELESS_ENST00000553532.1_Missense_Mutation_p.E942G	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	942					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						CTTGTACAGCTCCCGCCGCTC	0.527000													9	79					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14613530	14613530	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr12:14613530C>T	ENST00000544627.1	+	9	2604	c.2284C>T	c.(2284-2286)Cct>Tct	p.P762S	ATF7IP_ENST00000540793.1_Missense_Mutation_p.P754S|ATF7IP_ENST00000261168.4_Missense_Mutation_p.P754S|ATF7IP_ENST00000541654.1_3'UTR|ATF7IP_ENST00000536444.1_Missense_Mutation_p.P753S|ATF7IP_ENST00000543189.1_Missense_Mutation_p.P753S			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	754	Interaction with SETDB1.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						GTCAGTTCTTCCTGCACCCAA	0.473000													15	105					0	0	1	0	0
COL4A3BP	10087	broad.mit.edu	37	5	74722233	74722233	+	Missense_Mutation	SNP	G	G	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr5:74722233G>T	ENST00000380494.5	-	5	1096	c.803C>A	c.(802-804)gCa>gAa	p.A268E	COL4A3BP_ENST00000405807.4_Missense_Mutation_p.A140E|COL4A3BP_ENST00000261415.7_Missense_Mutation_p.A140E	NM_001130105.1	NP_001123577.1	Q9Y5P4	C43BP_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein	140					ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			breast(1)|kidney(1)|large_intestine(5)|lung(4)|skin(3)|stomach(1)|urinary_tract(1)	16		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		GTAGCCACTTGCTCCAGACAC	0.398000													5	77					5.9392e-07	6.37114e-07	1	1	0
GUSBP1	0	broad.mit.edu	37	5	21491473	21491473	+	RNA	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr5:21491473C>T	ENST00000607545.1	+	0	179					NR_027026.1																						GTAACCAGTTCAAGTTGGAAG	0.542000													4	47					0	0	1	0	0
OSBPL2	9885	broad.mit.edu	37	20	60854351	60854351	+	Silent	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr20:60854351C>T	ENST00000313733.3	+	7	832	c.630C>T	c.(628-630)agC>agT	p.S210S	OSBPL2_ENST00000439951.2_Silent_p.S118S|OSBPL2_ENST00000358053.2_Silent_p.S198S	NM_144498.1	NP_653081.1	Q9H1P3	OSBL2_HUMAN	oxysterol binding protein-like 2	210					lipid transport		lipid binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			GGGGCAAAAGCGTGGAGGCGG	0.592000													3	43					0	0	1	0	0
PPP1R10	5514	broad.mit.edu	37	6	30571928	30571928	+	Missense_Mutation	SNP	C	C	A			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr6:30571928C>A	ENST00000376511.2	-	14	1917	c.1365G>T	c.(1363-1365)atG>atT	p.M455I		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	455	Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						CCTTCTCCTCCATGTTATCAT	0.557000													6	144					0.217242	0.217242	1	1	0
SUGP2	10147	broad.mit.edu	37	19	19120892	19120892	+	Silent	SNP	G	G	A			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr19:19120892G>A	ENST00000601879.1	-	5	2407	c.2110C>T	c.(2110-2112)Cta>Tta	p.L704L	SUGP2_ENST00000600377.1_Silent_p.L718L|SUGP2_ENST00000452918.2_Silent_p.L704L|SUGP2_ENST00000337018.6_Silent_p.L704L|SUGP2_ENST00000456085.2_Silent_p.L473L			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	704					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						CCTGAGGATAGGAGGGTCTGG	0.642000													5	70					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51173693	51173693	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr16:51173693C>T	ENST00000440970.1	-	2	2580	c.2149G>A	c.(2149-2151)Gat>Aat	p.D717N	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.D814N	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	814					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TTTTTCTCATCAAAGGAACCT	0.512000													8	175					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23542322	23542322	+	Missense_Mutation	SNP	C	C	G			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr19:23542322C>G	ENST00000300619.7	-	4	3664	c.3459G>C	c.(3457-3459)aaG>aaC	p.K1153N	ZNF91_ENST00000397082.2_Missense_Mutation_p.K1121N|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	1153						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.K1153N(1)					all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TATGAATTTTCTTATGGTTAG	0.438000													3	55					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23905654	23905654	+	Missense_Mutation	SNP	T	T	G			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr13:23905654T>G	ENST00000382298.3	-	10	12949	c.12361A>C	c.(12361-12363)Att>Ctt	p.I4121L	SACS_ENST00000382292.3_Missense_Mutation_p.I4121L|SACS_ENST00000402364.1_Missense_Mutation_p.I3371L	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	4121					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AGCATAGCAATTAAATATGAA	0.358000													4	96					0	0	1	0	0
OR10R2	343406	broad.mit.edu	37	1	158450674	158450674	+	Splice_Site	SNP	G	G	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr1:158450674G>T	ENST00000368152.1	+	1	1007	c.1005_splice	c.e1+1	p.*336_splice	RP11-144L1.4_ENST00000419738.1_RNA|RP11-144L1.4_ENST00000426251.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					CTATATAATTGAAATATTATT	0.294000													3	28					0.115264	0.117251	1	1	0
AQP7	364	broad.mit.edu	37	9	33385614	33385614	+	Missense_Mutation	SNP	A	A	T	rs140995428	by1000genomes	TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr9:33385614A>T	ENST00000541274.1	-	5	830	c.381T>A	c.(379-381)agT>agA	p.S127R	AQP7_ENST00000539936.1_3'UTR|AQP7_ENST00000537089.1_3'UTR|AQP7_ENST00000377425.4_Intron			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCACAGAAAAACTCAAAGGAA	0.632000													4	66					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109365050	109365050	+	Missense_Mutation	SNP	G	G	A	rs111464054	byFrequency	TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr13:109365050G>A	ENST00000356711.2	+	3	394	c.268G>A	c.(268-270)Gtc>Atc	p.V90I	MYO16_ENST00000251041.5_Missense_Mutation_p.V90I|MYO16_ENST00000357550.2_Missense_Mutation_p.V90I	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	90					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCACACCCTCGTCTCCTCGGG	0.577000													4	88					0	0	1	0	0
SLC16A6	9120	broad.mit.edu	37	17	66267674	66267674	+	Silent	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr17:66267674C>T	ENST00000327268.4	-	6	791	c.627G>A	c.(625-627)gcG>gcA	p.A209A	SLC16A6_ENST00000580666.1_Silent_p.A209A|ARSG_ENST00000448504.2_Intron	NM_001174166.1	NP_001167637.1	O15403	MOT7_HUMAN	solute carrier family 16, member 6	209						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			large_intestine(3)|lung(8)|prostate(1)|skin(1)|urinary_tract(2)	15	all_cancers(12;1.24e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)		Pyruvic acid(DB00119)	TTTTCGGTGACGCTGGTCCTC	0.463000													4	116					0	0	1	0	0
KCNE3	10008	broad.mit.edu	37	11	74168562	74168562	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr11:74168562G>A	ENST00000310128.4	-	3	466	c.47C>T	c.(46-48)gCc>gTc	p.A16V	KCNE3_ENST00000525550.1_Missense_Mutation_p.A16V|RP11-702H23.4_ENST00000533008.1_RNA	NM_005472.4	NP_005463.1	Q9Y6H6	KCNE3_HUMAN	potassium voltage-gated channel, Isk-related family, member 3	16						integral to membrane	voltage-gated potassium channel activity			cervix(1)|large_intestine(1)|lung(1)|ovary(1)	4	Breast(11;2.86e-06)					CTTCAGCACGGCATGCAGGCT	0.577000													4	62					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21170750	21170750	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr16:21170750C>T	ENST00000261383.3	-	1	12	c.13G>A	c.(13-15)Ggg>Agg	p.G5R	TMEM159_ENST00000261388.3_Intron|TMEM159_ENST00000233047.4_Intron|TMEM159_ENST00000572599.1_Intron|TMEM159_ENST00000574092.1_Intron|DNAH3_ENST00000415178.1_Missense_Mutation_p.G5R|TMEM159_ENST00000451578.2_Intron|TMEM159_ENST00000572258.1_Intron	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	5	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCGAGGCGCCCTGTAGCTCCC	0.632000													4	75					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													4	44					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16701504	16701504	+	Missense_Mutation	SNP	G	G	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr5:16701504G>T	ENST00000513610.1	-	25	3454	c.3000C>A	c.(2998-3000)gaC>gaA	p.D1000E	MYO10_ENST00000505695.1_Missense_Mutation_p.D339E|MYO10_ENST00000515803.1_Missense_Mutation_p.D339E|MYO10_ENST00000427430.2_Missense_Mutation_p.D357E|MYO10_ENST00000274203.9_Missense_Mutation_p.D357E	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	1000					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity	p.D1000D(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						AGGCGTCGTCGTCGGCTTCGA	0.617000													3	18					0.004672	0.00492229	1	1	0
ANO5	203859	broad.mit.edu	37	11	22239825	22239825	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr11:22239825C>T	ENST00000324559.8	+	4	489	c.172C>T	c.(172-174)Cgg>Tgg	p.R58W		NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	58						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CCTGAGGCGGCGGCTTATGGT	0.408000													5	47					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3263667	3263667	+	Silent	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr8:3263667C>T	ENST00000520002.1	-	16	2706	c.2151G>A	c.(2149-2151)ggG>ggA	p.G717G	CSMD1_ENST00000539096.1_Silent_p.G716G|CSMD1_ENST00000537824.1_Silent_p.G716G|CSMD1_ENST00000602723.1_Silent_p.G717G|CSMD1_ENST00000400186.3_Silent_p.G717G|CSMD1_ENST00000602557.1_Silent_p.G717G|CSMD1_ENST00000542608.1_Silent_p.G716G			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	717	Sushi 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AAACCGAGCTCCCGAGTAGAA	0.478000													3	18					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8390957	8390957	+	Silent	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr1:8390957C>T	ENST00000471889.1	+	5	1789	c.1404C>T	c.(1402-1404)ccC>ccT	p.P468P	SLC45A1_ENST00000481265.1_3'UTR|SLC45A1_ENST00000289877.8_Silent_p.P468P|SLC45A1_ENST00000377479.2_Silent_p.P502P			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	468					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GAGGGGGTCCCGAAACCAGCA	0.607000													5	97					0	0	1	0	0
MORN4	118812	broad.mit.edu	37	10	99376504	99376504	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr10:99376504C>T	ENST00000335628.3	-	3	396	c.397G>A	c.(397-399)Gga>Aga	p.G133R	MORN4_ENST00000478953.1_Intron|MORN4_ENST00000307450.6_Missense_Mutation_p.G75R|PI4K2A_ENST00000555577.1_Intron|PI4K2A_ENST00000370649.3_Intron			Q8NDC4	MORN4_HUMAN	MORN repeat containing 4	75										large_intestine(1)|lung(1)|stomach(2)	4						ATGAAGACTCCGACGCCATTA	0.473000													11	106					0	0	1	0	0
ABCC4	10257	broad.mit.edu	37	13	95715069	95715069	+	Silent	SNP	G	G	A	rs11568652	byFrequency	TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr13:95715069G>A	ENST00000376887.4	-	26	3369	c.3255C>T	c.(3253-3255)atC>atT	p.I1085I	ABCC4_ENST00000412704.1_Silent_p.I1038I	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	1085	ABC transporter 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	AAAGGGCTGAGATGAGGGAAC	0.398000													6	60					0	0	1	0	0
KIAA1586	57691	broad.mit.edu	37	6	56918134	56918134	+	Silent	SNP	A	A	G			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr6:56918134A>G	ENST00000370733.4	+	4	1044	c.837A>G	c.(835-837)gtA>gtG	p.V279V	KIAA1586_ENST00000545356.1_Silent_p.V252V	NM_020931.2	NP_065982.1	Q9HCI6	K1586_HUMAN	KIAA1586	279							nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)	18	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			ATGGAGAGGTAAATTGTTTAA	0.303000													4	43					0	0	1	0	0
KIAA1009	22832	broad.mit.edu	37	6	84896094	84896094	+	Missense_Mutation	SNP	T	T	C			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr6:84896094T>C	ENST00000403245.3	-	12	1471	c.1357A>G	c.(1357-1359)Act>Gct	p.T453A	KIAA1009_ENST00000257766.4_Missense_Mutation_p.T377A|KIAA1009_ENST00000461137.1_5'UTR	NM_014895.2	NP_055710.2	Q5TB80	QN1_HUMAN	KIAA1009	453					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	43		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		GAATTAACAGTTATTTTTTTC	0.294000													5	72					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885613	88885613	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr8:88885613G>A	ENST00000319675.3	-	1	683	c.587C>T	c.(586-588)gCg>gTg	p.A196V		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	196										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						AGAGTGATACGCGTGGATGCT	0.557000													5	108					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179730612	179730612	+	Missense_Mutation	SNP	T	T	C			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr2:179730612T>C	ENST00000420890.2	-	17	2723	c.2606A>G	c.(2605-2607)cAg>cGg	p.Q869R	CCDC141_ENST00000295723.5_Missense_Mutation_p.Q294R	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	294	Ig-like.						protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CAGCTGCTGCTGTAGGTTCTT	0.502000													6	173					0	0	1	0	0
RYBP	23429	broad.mit.edu	37	3	72428576	72428576	+	Missense_Mutation	SNP	T	T	G			TCGA-EJ-A6RC-01A-11D-A32B-08	TCGA-EJ-A6RC-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	379affa6-98e2-459e-ac52-5ce57f69e2dd	bb8583d6-621a-4f59-87af-0a72dd30e1a6	g.chr3:72428576T>G	ENST00000477973.1	-	2	425	c.426A>C	c.(424-426)aaA>aaC	p.K142N		NM_012234.5	NP_036366.3	Q8N488	RYBP_HUMAN	RING1 and YY1 binding protein	0					apoptosis|histone H2A monoubiquitination|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			prostate(1)|upper_aerodigestive_tract(1)	2		Prostate(10;0.00174)|Lung NSC(201;0.0659)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;0.000197)|Epithelial(33;0.00068)|LUSC - Lung squamous cell carcinoma(21;0.00228)|Lung(16;0.00677)|KIRC - Kidney renal clear cell carcinoma(39;0.198)|Kidney(39;0.232)		GATCCGAGGTTTTCTGAAATG	0.368000													6	37					0	0	1	0	0