Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CR1	1378	broad.mit.edu	37	1	207787753	207787753	+	Nonsense_Mutation	SNP	C	C	T	rs55749440		TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr1:207787753C>T	ENST00000367049.4	+	40	6580	c.6580C>T	c.(6580-6582)Cga>Tga	p.R2194*	CR1_ENST00000367052.1_Nonsense_Mutation_p.R1744*|CR1_ENST00000367053.1_Nonsense_Mutation_p.R1744*|CR1_ENST00000400960.2_Nonsense_Mutation_p.R1744*|CR1_ENST00000367051.1_Nonsense_Mutation_p.R1744*	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1744					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity	p.R1749*(9)|p.R2194*(9)|p.R1744*(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CTTTAGGTTCCGATTAAAAGG	0.423000													3	47					0	0	0.009096	0	0
S100A8	6279	broad.mit.edu	37	1	153362715	153362715	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr1:153362715T>C	ENST00000368733.3	-	3	315	c.146A>G	c.(145-147)aAg>aGg	p.K49R	S100A8_ENST00000477801.1_5'UTR|S100A8_ENST00000368732.1_Missense_Mutation_p.K49R	NM_002964.4	NP_002955.2	P05109	S10A8_HUMAN	S100 calcium binding protein A8	49	EF-hand 2.				chemotaxis	cytoplasm|cytoskeleton|plasma membrane	calcium ion binding|protein binding			breast(1)|endometrium(1)|lung(1)|urinary_tract(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTCTGCACCCTTTTTCTGTCA	0.507000													3	149					0	0	0.004672	0	0
SPTBN2	6712	broad.mit.edu	37	11	66457286	66457286	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:66457286G>A	ENST00000533211.1	-	29	6270	c.5939C>T	c.(5938-5940)gCg>gTg	p.A1980V	SPTBN2_ENST00000309996.2_Missense_Mutation_p.A1980V|SPTBN2_ENST00000529997.1_Missense_Mutation_p.A1980V			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1980					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						CTCCTCGGCCGCATAGTGGCT	0.602000													4	141					0	0	0.009096	0	0
TTN	7273	broad.mit.edu	37	2	179412752	179412752	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr2:179412752A>G	ENST00000589042.1	-	339	93825	c.93601T>C	c.(93601-93603)Ttc>Ctc	p.F31201L	TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.F29560L|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.F22136L|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.F22328L|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.F22261L|TTN_ENST00000342992.6_Missense_Mutation_p.F28633L|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29560	Fibronectin type-III 127.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.F22136L(2)|p.F22261L(1)|p.F28633L(1)|p.F28631L(1)|p.F22328L(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGAAGAGAAGGCTTCTCTG	0.443000													33	52					0	0	0.012213	0	0
KCNJ11	3767	broad.mit.edu	37	11	17409276	17409276	+	Silent	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:17409276G>A	ENST00000339994.4	-	1	930	c.363C>T	c.(361-363)ttC>ttT	p.F121F	KCNJ11_ENST00000528731.1_Silent_p.F34F	NM_000525.3	NP_000516.3	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 11	34						integral to membrane	ATP-activated inward rectifier potassium channel activity	p.F121F(1)		endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(3)|skin(2)	16				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		TGGAGAAAAGGAAGGCAGACG	0.607000													8	41					0	0	0.006214	0	0
ANKRD20A8P	0	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr2:95522786T>C	ENST00000432432.2	-	0	241					NR_040113.1													p.K44K(1)									CGGCGTCGCCTTTGACAGCTG	0.687000													3	86					0	0	0.000602	0	0
CCDC34	91057	broad.mit.edu	37	11	27379087	27379087	+	Splice_Site	SNP	T	T	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:27379087T>C	ENST00000317945.6	-	2	400	c.359_splice	c.e2-1	p.T121_splice	CCDC34_ENST00000328697.6_Splice_Site_p.T121_splice	NM_080654.2	NP_542385.1	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34	121								p.T121A(2)		endometrium(2)|large_intestine(4)|lung(1)|prostate(1)|urinary_tract(1)	9						TCAACCTGAGTGCTACAAAAG	0.398000													17	75					0	0	0.004990	0	0
DENND2D	79961	broad.mit.edu	37	1	111737241	111737241	+	Silent	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr1:111737241G>A	ENST00000357640.4	-	7	982	c.753C>T	c.(751-753)gcC>gcT	p.A251A	DENND2D_ENST00000369752.5_Silent_p.A248A	NM_024901.3	NP_079177.2	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	251	DENN.							p.A251A(1)		breast(1)|endometrium(1)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		TCTCCAGCACGGCAGAGGCAA	0.537000													13	55					0	0	0.001855	0	0
KCNJ11	3767	broad.mit.edu	37	11	17409274	17409274	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:17409274A>C	ENST00000339994.4	-	1	932	c.365T>G	c.(364-366)cTt>cGt	p.L122R	KCNJ11_ENST00000528731.1_Missense_Mutation_p.L35R	NM_000525.3	NP_000516.3	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 11	35						integral to membrane	ATP-activated inward rectifier potassium channel activity	p.L122R(1)		endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(3)|skin(2)	16				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		AATGGAGAAAAGGAAGGCAGA	0.607000													8	41					0	0	0.004482	0	0
KRT222	125113	broad.mit.edu	37	17	38821349	38821349	+	Translation_Start_Site	SNP	C	C	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr17:38821349C>A	ENST00000476049.1	-	1	44	c.3G>T	c.(1-3)atG>atT	p.M1I	KRT222_ENST00000394052.3_Start_Codon_SNP_p.M1I			Q8N1A0	KT222_HUMAN	keratin 222	1						intermediate filament	structural molecule activity	p.M1I(1)		breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(2)|skin(1)	15						GGGACAGTTCCATTCTTTTCC	0.512000													4	125					0.00024832	0.000292141	0.009096	1	0
OR10G8	219869	broad.mit.edu	37	11	123900753	123900753	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:123900753C>T	ENST00000431524.1	+	1	457	c.424C>T	c.(424-426)Ctt>Ttt	p.L142F		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L142F(1)		breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CTCGTGTACTCTTCTGGCCAC	0.557000													6	152					0	0	0.001168	0	0
CABP5	56344	broad.mit.edu	37	19	48533840	48533840	+	Splice_Site	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr19:48533840C>T	ENST00000293255.2	-	6	627		c.e6-1			NM_019855.4	NP_062829.1	Q9NP86	CABP5_HUMAN	calcium binding protein 5						signal transduction	cytoplasm	calcium ion binding	p.?(1)		endometrium(1)|large_intestine(3)|lung(3)|prostate(2)|skin(2)	11		all_cancers(25;1.86e-08)|all_lung(116;1.14e-06)|all_epithelial(76;1.16e-06)|Lung NSC(112;2.54e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;4.09e-05)|all cancers(93;0.000322)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.058)		TTCACAAACTCTGCAAAGAAA	0.493000													31	62					0	0	0.003755	0	0
MPEG1	219972	broad.mit.edu	37	11	58978336	58978336	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:58978336A>C	ENST00000361050.3	-	1	2088	c.2003T>G	c.(2002-2004)cTg>cGg	p.L668R		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	668						integral to membrane		p.L668R(1)		NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				AACAACAGCCAGAATGGTGGT	0.557000													32	79					0	0	0.013726	0	0
LINC00969	0	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													3	24					0	0	0.009096	0	0
ATF6B	1388	broad.mit.edu	37	6	32093899	32093899	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr6:32093899G>T	ENST00000375201.4	-	5	509	c.464C>A	c.(463-465)tCc>tAc	p.S155Y	ATF6B_ENST00000375203.3_Missense_Mutation_p.S158Y|ATF6B_ENST00000468502.1_5'UTR			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	158					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.S158Y(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						ATTACCTGAGGAATCATCAGA	0.507000													42	81					5.7616e-29	7.51513e-29	0.014410	1	0
ADAMTS19	171019	broad.mit.edu	37	5	128983512	128983512	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr5:128983512G>A	ENST00000274487.4	+	12	2054	c.1909G>A	c.(1909-1911)Gga>Aga	p.G637R	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	637	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.G637R(2)		NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		ACATCTGGCCGGAGAGTGGAG	0.522000													55	27					0	0	0.014410	0	0
FOXC1	2296	broad.mit.edu	37	6	1611154	1611154	+	Silent	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr6:1611154C>T	ENST00000380874.2	+	1	474	c.474C>T	c.(472-474)tcC>tcT	p.S158S		NM_001453.2	NP_001444.2	Q12948	FOXC1_HUMAN	forkhead box C1	158					anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding	p.S158S(2)		large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	8	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		ACCCGGACTCCTACAACATGT	0.627000													8	38					0	0	0.003080	0	0
AC015849.16	0	broad.mit.edu	37	17	34233423	34233423	+	RNA	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr17:34233423G>A	ENST00000587132.1	-	0	4604																											ATGGTGAAATGTTGGAGGCTG	0.468000													10	9					0	0	0.006214	0	0
VARS	7407	broad.mit.edu	37	6	31752254	31752254	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr6:31752254C>T	ENST00000375663.3	-	12	1933	c.1493G>A	c.(1492-1494)cGc>cAc	p.R498H	VARS_ENST00000444930.2_Missense_Mutation_p.R203H	NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	498					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity	p.R498H(2)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	GAGCAGGGTGCGACCTGTCAG	0.597000													25	56					0	0	0.006320	0	0
CDH5	1003	broad.mit.edu	37	16	66436911	66436911	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr16:66436911G>A	ENST00000341529.3	+	12	2342	c.2194G>A	c.(2194-2196)Ggc>Agc	p.G732S	CDH5_ENST00000539168.1_Missense_Mutation_p.G171S	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	732					adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding	p.G732S(1)		central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		GCACATCTACGGCTACGAGGG	0.642000													11	19					0	0	0.010729	0	0
ADRBK1	156	broad.mit.edu	37	11	67052768	67052768	+	Silent	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:67052768G>A	ENST00000308595.5	+	21	2207	c.1917G>A	c.(1915-1917)gaG>gaA	p.E639E	ADRBK1_ENST00000526285.1_Intron	NM_001619.3	NP_001610.2	P25098	ARBK1_HUMAN	adrenergic, beta, receptor kinase 1	639	PH.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity	p.E639E(2)		cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)	22			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GCGACCCTGAGCTGGTGCAGT	0.697000													21	31					0	0	0.010504	0	0
RASAL1	8437	broad.mit.edu	37	12	113544983	113544983	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr12:113544983G>T	ENST00000546530.1	-	16	1864	c.1579C>A	c.(1579-1581)Ccc>Acc	p.P527T	RASAL1_ENST00000446861.3_Missense_Mutation_p.P526T|RASAL1_ENST00000261729.5_Missense_Mutation_p.P526T|RASAL1_ENST00000418411.2_5'UTR|RASAL1_ENST00000548055.1_Missense_Mutation_p.P526T	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	526					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity	p.P526T(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						GGGTGCAGGGGGGCCATCCAC	0.622000													18	30					2.48551e-13	3.17299e-13	0.004990	1	0
PIPSL	0	broad.mit.edu	37	10	95718641	95718641	+	RNA	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr10:95718641C>T	ENST00000480546.1	-	0	2656					NR_002319.2																						CACAGCATTTCGAATGGCTTC	0.542000													10	62					0	0	0.006214	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr1:145302714A>G	ENST00000342960.5	+	8	1187	c.1152A>G	c.(1150-1152)ttA>ttG	p.L384L	NBPF10_ENST00000369338.1_Silent_p.L113L|NBPF10_ENST00000369339.2_Silent_p.L113L|RP11-458D21.5_ENST00000468030.1_3'UTR	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	384								p.L113L(3)|p.L384L(3)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													7	156					0	0	0.001984	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22663087	22663087	+	RNA	SNP	A	A	G	rs1054158		TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr22:22663087A>G	ENST00000426066.1	+	0	526					NR_027293.1																						GCTGCCACATAAGTTGTCCTT	0.303000													3	46					0	0	0.009096	0	0
RRP7B	0	broad.mit.edu	37	22	42971987	42971987	+	RNA	SNP	T	T	C	rs137064	by1000genomes	TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr22:42971987T>C	ENST00000357802.2	-	0	733																		p.Q59R(1)									CAGCTCTTTTTGGCTGCGCTT	0.672000													3	23					0	0	0.009096	0	0
RIPK1	8737	broad.mit.edu	37	6	3077128	3077128	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr6:3077128A>G	ENST00000259808.4	+	2	369	c.71A>G	c.(70-72)gAc>gGc	p.D24G	RIPK1_ENST00000541791.1_Missense_Mutation_p.D24G|RIPK1_ENST00000479389.1_Intron|RIPK1_ENST00000380409.2_Missense_Mutation_p.D24G			Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine kinase 1	24	Protein kinase.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity	p.D24G(2)		breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	23	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				GCAGAACTGGACAGCGGAGGC	0.478000													8	49					0	0	0.003080	0	0
PRKCSH	5589	broad.mit.edu	37	19	11552168	11552168	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr19:11552168A>G	ENST00000252455.2	+	6	800	c.464A>G	c.(463-465)aAg>aGg	p.K155R	PRKCSH_ENST00000591462.1_Missense_Mutation_p.K155R|PRKCSH_ENST00000412601.1_Missense_Mutation_p.K155R|PRKCSH_ENST00000589838.1_Missense_Mutation_p.K155R|PRKCSH_ENST00000587327.1_Missense_Mutation_p.K155R|PRKCSH_ENST00000592741.1_Missense_Mutation_p.K155R	NM_002743.2	NP_002734.2	P14314	GLU2B_HUMAN	protein kinase C substrate 80K-H	155					innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding	p.K155R(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(3)	19						CGGGAGGAGAAGCAGGTAAGG	0.612000													52	113					0	0	0.014410	0	0
FAT1	2195	broad.mit.edu	37	4	187540359	187540359	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr4:187540359A>G	ENST00000441802.2	-	10	7590	c.7381T>C	c.(7381-7383)Tac>Cac	p.Y2461H		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2461	Cadherin 22.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding	p.Y2461H(2)|p.Y2464H(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TTAAGACTGTAAAATGGCTTC	0.443000										HNSCC(5;0.00058)			6	234					0	0	0.001168	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													4	55					0	0	0.009096	0	0
CSMD3	114788	broad.mit.edu	37	8	113529332	113529332	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr8:113529332C>T	ENST00000297405.5	-	28	4931	c.4687G>A	c.(4687-4689)Gag>Aag	p.E1563K	CSMD3_ENST00000352409.3_Missense_Mutation_p.E1563K|CSMD3_ENST00000455883.2_Missense_Mutation_p.E1459K|CSMD3_ENST00000343508.3_Missense_Mutation_p.E1523K	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1563	Sushi 8.					integral to membrane|plasma membrane		p.E1563K(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATTCTTTCCTCTCCTTGAAGT	0.438000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			32	66					0	0	0.009535	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28315754	28315754	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr21:28315754C>A	ENST00000284987.5	-	3	1471	c.1350G>T	c.(1348-1350)aaG>aaT	p.K450N		NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	450	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding	p.K450N(2)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						TGGACCAGGGCTTAGATGCAT	0.448000													4	34					0.00024832	0.000292141	0.009096	1	0
ARHGEF15	22899	broad.mit.edu	37	17	8221715	8221715	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr17:8221715G>A	ENST00000361926.3	+	10	1825	c.1715G>A	c.(1714-1716)cGc>cAc	p.R572H	ARHGEF15_ENST00000421050.1_Missense_Mutation_p.R572H|AC135178.7_ENST00000458568.1_RNA	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	572	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.R572H(1)		breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						AATATCCTGCGCCAGACAGAA	0.627000													47	84					0	0	0.014410	0	0
SEPHS1	22929	broad.mit.edu	37	10	13375855	13375855	+	Silent	SNP	T	T	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr10:13375855T>C	ENST00000327347.5	-	5	897	c.522A>G	c.(520-522)ggA>ggG	p.G174G	SEPHS1_ENST00000378614.4_Silent_p.G174G|SEPHS1_ENST00000545675.1_Silent_p.G174G|SEPHS1_ENST00000537130.1_Silent_p.G107G	NM_001195602.1|NM_012247.4	NP_001182531.1|NP_036379.2	P49903	SPS1_HUMAN	selenophosphate synthetase 1	174					protein modification process		ATP binding|GTP binding|selenide, water dikinase activity	p.G174G(2)		cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|stomach(1)	16						TGGTAGCCACTCCTCCCAGGA	0.438000													16	28					0	0	0.004990	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22663086	22663086	+	RNA	SNP	T	T	G	rs1054157	by1000genomes	TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr22:22663086T>G	ENST00000426066.1	+	0	525					NR_027293.1																						AGCTGCCACATAAGTTGTCCT	0.299000													3	46					0	0	0.009096	0	0
OR4C3	256144	broad.mit.edu	37	11	48347071	48347071	+	Missense_Mutation	SNP	C	C	A	rs138317832		TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:48347071C>A	ENST00000319856.4	+	1	600	c.579C>A	c.(577-579)ttC>ttA	p.F193L		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	166					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F193L(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						GGTTGCCCTTCTGTGGGCCCA	0.532000													23	63					1.96895e-08	2.46118e-08	0.002780	1	0
OR4D9	390199	broad.mit.edu	37	11	59282589	59282589	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:59282589T>G	ENST00000329328.3	+	1	204	c.204T>G	c.(202-204)atT>atG	p.I68M		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I68M(1)		endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						ACCTGTCTATTCTTGACATCT	0.443000													79	123					0	0	0.014410	0	0
SNAP25	6616	broad.mit.edu	37	20	10273562	10273562	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr20:10273562C>G	ENST00000304886.2	+	5	404	c.196C>G	c.(196-198)Cat>Gat	p.H66D	SNAP25_ENST00000254976.2_Intron|SNAP25-AS1_ENST00000421143.2_RNA|SNAP25-AS1_ENST00000453544.1_RNA	NM_003081.3	NP_003072.2	P60880	SNP25_HUMAN	synaptosomal-associated protein, 25kDa	66	Interaction with CENPF (By similarity).|t-SNARE coiled-coil homology 1.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome		p.H66D(1)		endometrium(1)|large_intestine(2)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	18					Botulinum Toxin Type A(DB00083)	AGGCATGAACCATATCAACCA	0.413000													12	84					0	0	0.013537	0	0
STARD3	0	broad.mit.edu	37	17	37814071	37814071	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr17:37814071C>T	ENST00000336308.5	+	4	559	c.341C>T	c.(340-342)gCc>gTc	p.A114V	STARD3_ENST00000580611.1_Missense_Mutation_p.A88V|STARD3_ENST00000578232.1_3'UTR|STARD3_ENST00000544210.2_Missense_Mutation_p.A114V|STARD3_ENST00000394250.4_Missense_Mutation_p.A114V	NM_001165937.1|NM_006804.3	NP_001159409.1|NP_006795.3	Q14849	STAR3_HUMAN	StAR-related lipid transfer (START) domain containing 3	114	MENTAL.				cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity	p.A114V(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|prostate(2)|stomach(1)	14	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CTAGGCTATGCCGTGCTGCGG	0.647000													4	90					0	0	0.009096	0	0
AGBL1	123624	broad.mit.edu	37	15	86838596	86838596	+	Silent	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr15:86838596G>A	ENST00000441037.2	+	16	2288	c.2193G>A	c.(2191-2193)acG>acA	p.T731T	AGBL1_ENST00000421325.2_Silent_p.T731T|AGBL1_ENST00000389298.3_Silent_p.T462T	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	731					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding	p.T731T(1)		NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TGACCATCACGGCCATGCCTG	0.498000													37	68					0	0	0.007835	0	0
HCN4	10021	broad.mit.edu	37	15	73615456	73615456	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr15:73615456G>T	ENST00000261917.3	-	8	3971	c.2978C>A	c.(2977-2979)aCg>aAg	p.T993K		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	993	Pro-rich.				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity	p.T993K(1)		NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		TGTCTCTGGCGTGCTCAGTGG	0.697000													7	13					0.000157383	0.000192714	0.003080	1	0
DPT	1805	broad.mit.edu	37	1	168698284	168698284	+	Silent	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr1:168698284C>T	ENST00000367817.3	-	1	218	c.129G>A	c.(127-129)cgG>cgA	p.R43R		NM_001937.4	NP_001928.2	Q07507	DERM_HUMAN	dermatopontin	43	2 X 53-55 AA tandem repeats.				cell adhesion	extracellular space|proteinaceous extracellular matrix		p.R43R(1)		kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)	12	all_hematologic(923;0.208)					TGAAGCCTTGCCGGTTCAAAT	0.542000													4	64					0	0	0.009096	0	0
HPS1	3257	broad.mit.edu	37	10	100177455	100177455	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr10:100177455G>A	ENST00000325103.6	-	20	2202	c.1969C>T	c.(1969-1971)Cgc>Tgc	p.R657C	HPS1_ENST00000361490.4_Missense_Mutation_p.R657C|HPS1_ENST00000467246.1_5'UTR	NM_000195.3	NP_000186.2	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1	657					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity	p.R657C(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		TCGGTTGGGCGGTTCTTGCTG	0.662000									Hermansky-Pudlak syndrome				21	31					0	0	0.003330	0	0
LIMK1	3984	broad.mit.edu	37	7	73498339	73498339	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr7:73498339T>G	ENST00000336180.2	+	1	70	c.19T>G	c.(19-21)Tgt>Ggt	p.C7G	LIMK1_ENST00000418310.1_Intron	NM_002314.3	NP_002305.1	P53667	LIMK1_HUMAN	LIM domain kinase 1	7					actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				GACGCTACTTTGTTGCACCTG	0.776000													4	5					0	0	0.009096	0	0
MALAT1	0	broad.mit.edu	37	11	65269936	65269936	+	RNA	SNP	A	A	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr11:65269936A>T	ENST00000534336.1	+	0	4704					NR_002819.2																						TCCATTGTTTAACTGCAAAAC	0.264000													10	23					0	0	0.006214	0	0
TBX19	9095	broad.mit.edu	37	1	168278015	168278015	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr1:168278015G>C	ENST00000367821.3	+	7	1003	c.952G>C	c.(952-954)Gtt>Ctt	p.V318L	TBX19_ENST00000465440.1_3'UTR	NM_005149.2	NP_005140.1	O60806	TBX19_HUMAN	T-box 19	318					anatomical structure morphogenesis	nucleus	DNA binding	p.V318L(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(11)|prostate(2)|skin(2)|urinary_tract(1)	34	all_hematologic(923;0.215)					TAATCTGCAAGTTTTCTCGGG	0.463000													3	92					0	0	0.004672	0	0
CR1	1378	broad.mit.edu	37	1	207787753	207787753	+	Nonsense_Mutation	SNP	C	C	T	rs55749440		TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr1:207787753C>T	ENST00000367049.4	+	40	6580	c.6580C>T	c.(6580-6582)Cga>Tga	p.R2194*	CR1_ENST00000400960.2_Nonsense_Mutation_p.R1744*|CR1_ENST00000367051.1_Nonsense_Mutation_p.R1744*|CR1_ENST00000367053.1_Nonsense_Mutation_p.R1744*|CR1_ENST00000367052.1_Nonsense_Mutation_p.R1744*	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1744					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity	p.R1749*(9)|p.R2194*(9)|p.R1744*(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CTTTAGGTTCCGATTAAAAGG	0.423000													3	47					0	0	0.009096	0	0
S100A8	6279	broad.mit.edu	37	1	153362715	153362715	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr1:153362715T>C	ENST00000368733.3	-	3	315	c.146A>G	c.(145-147)aAg>aGg	p.K49R	S100A8_ENST00000477801.1_5'UTR|S100A8_ENST00000368732.1_Missense_Mutation_p.K49R	NM_002964.4	NP_002955.2	P05109	S10A8_HUMAN	S100 calcium binding protein A8	49	EF-hand 2.				chemotaxis	cytoplasm|cytoskeleton|plasma membrane	calcium ion binding|protein binding			breast(1)|endometrium(1)|lung(1)|urinary_tract(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTCTGCACCCTTTTTCTGTCA	0.507000													3	149					0	0	0.004672	0	0
SPTBN2	6712	broad.mit.edu	37	11	66457286	66457286	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr11:66457286G>A	ENST00000533211.1	-	29	6270	c.5939C>T	c.(5938-5940)gCg>gTg	p.A1980V	SPTBN2_ENST00000309996.2_Missense_Mutation_p.A1980V|SPTBN2_ENST00000529997.1_Missense_Mutation_p.A1980V			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1980					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						CTCCTCGGCCGCATAGTGGCT	0.602000													4	141					0	0	0.009096	0	0
TTN	7273	broad.mit.edu	37	2	179412752	179412752	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr2:179412752A>G	ENST00000589042.1	-	339	93825	c.93601T>C	c.(93601-93603)Ttc>Ctc	p.F31201L	TTN_ENST00000342992.6_Missense_Mutation_p.F28633L|TTN_ENST00000359218.5_Missense_Mutation_p.F22261L|TTN_ENST00000460472.2_Missense_Mutation_p.F22136L|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.F22328L|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.F29560L|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29560	Fibronectin type-III 127.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.F22136L(2)|p.F22261L(1)|p.F28633L(1)|p.F28631L(1)|p.F22328L(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGAAGAGAAGGCTTCTCTG	0.443000													33	52					0	0	0.012213	0	0
CABP5	56344	broad.mit.edu	37	19	48533840	48533840	+	Splice_Site	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr19:48533840C>T	ENST00000293255.2	-	6	627		c.e6-1			NM_019855.4	NP_062829.1	Q9NP86	CABP5_HUMAN	calcium binding protein 5						signal transduction	cytoplasm	calcium ion binding	p.?(1)		endometrium(1)|large_intestine(3)|lung(3)|prostate(2)|skin(2)	11		all_cancers(25;1.86e-08)|all_lung(116;1.14e-06)|all_epithelial(76;1.16e-06)|Lung NSC(112;2.54e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;4.09e-05)|all cancers(93;0.000322)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.058)		TTCACAAACTCTGCAAAGAAA	0.493000													31	62					0	0	0.003755	0	0
KCNJ11	3767	broad.mit.edu	37	11	17409276	17409276	+	Silent	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr11:17409276G>A	ENST00000339994.4	-	1	930	c.363C>T	c.(361-363)ttC>ttT	p.F121F	KCNJ11_ENST00000528731.1_Silent_p.F34F	NM_000525.3	NP_000516.3	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 11	34						integral to membrane	ATP-activated inward rectifier potassium channel activity	p.F121F(1)		endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(3)|skin(2)	16				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		TGGAGAAAAGGAAGGCAGACG	0.607000													8	41					0	0	0.006214	0	0
STARD3	0	broad.mit.edu	37	17	37814071	37814071	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr17:37814071C>T	ENST00000336308.5	+	4	559	c.341C>T	c.(340-342)gCc>gTc	p.A114V	STARD3_ENST00000580611.1_Missense_Mutation_p.A88V|STARD3_ENST00000544210.2_Missense_Mutation_p.A114V|STARD3_ENST00000578232.1_3'UTR|STARD3_ENST00000394250.4_Missense_Mutation_p.A114V	NM_001165937.1|NM_006804.3	NP_001159409.1|NP_006795.3	Q14849	STAR3_HUMAN	StAR-related lipid transfer (START) domain containing 3	114	MENTAL.				cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity	p.A114V(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|prostate(2)|stomach(1)	14	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CTAGGCTATGCCGTGCTGCGG	0.647000													4	90					0	0	0.009096	0	0
CCDC34	91057	broad.mit.edu	37	11	27379087	27379087	+	Splice_Site	SNP	T	T	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr11:27379087T>C	ENST00000317945.6	-	2	400	c.359_splice	c.e2-1	p.T121_splice	CCDC34_ENST00000328697.6_Splice_Site_p.T121_splice	NM_080654.2	NP_542385.1	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34	121								p.T121A(2)		endometrium(2)|large_intestine(4)|lung(1)|prostate(1)|urinary_tract(1)	9						TCAACCTGAGTGCTACAAAAG	0.398000													17	75					0	0	0.004990	0	0
DENND2D	79961	broad.mit.edu	37	1	111737241	111737241	+	Silent	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr1:111737241G>A	ENST00000357640.4	-	7	982	c.753C>T	c.(751-753)gcC>gcT	p.A251A	DENND2D_ENST00000369752.5_Silent_p.A248A	NM_024901.3	NP_079177.2	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	251	DENN.							p.A251A(1)		breast(1)|endometrium(1)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		TCTCCAGCACGGCAGAGGCAA	0.537000													13	55					0	0	0.001855	0	0
KCNJ11	3767	broad.mit.edu	37	11	17409274	17409274	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr11:17409274A>C	ENST00000339994.4	-	1	932	c.365T>G	c.(364-366)cTt>cGt	p.L122R	KCNJ11_ENST00000528731.1_Missense_Mutation_p.L35R	NM_000525.3	NP_000516.3	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 11	35						integral to membrane	ATP-activated inward rectifier potassium channel activity	p.L122R(1)		endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(3)|skin(2)	16				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		AATGGAGAAAAGGAAGGCAGA	0.607000													8	41					0	0	0.004482	0	0
KRT222	125113	broad.mit.edu	37	17	38821349	38821349	+	Translation_Start_Site	SNP	C	C	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr17:38821349C>A	ENST00000476049.1	-	1	44	c.3G>T	c.(1-3)atG>atT	p.M1I	KRT222_ENST00000394052.3_Start_Codon_SNP_p.M1I			Q8N1A0	KT222_HUMAN	keratin 222	1						intermediate filament	structural molecule activity	p.M1I(1)		breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(2)|skin(1)	15						GGGACAGTTCCATTCTTTTCC	0.512000													4	125					0.00024832	0.000301154	0.009096	1	0
OR10G8	219869	broad.mit.edu	37	11	123900753	123900753	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr11:123900753C>T	ENST00000431524.1	+	1	457	c.424C>T	c.(424-426)Ctt>Ttt	p.L142F		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L142F(1)		breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CTCGTGTACTCTTCTGGCCAC	0.557000													6	152					0	0	0.001168	0	0
MPEG1	219972	broad.mit.edu	37	11	58978336	58978336	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr11:58978336A>C	ENST00000361050.3	-	1	2088	c.2003T>G	c.(2002-2004)cTg>cGg	p.L668R		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	668						integral to membrane		p.L668R(1)		NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				AACAACAGCCAGAATGGTGGT	0.557000													32	79					0	0	0.013726	0	0
ATF6B	1388	broad.mit.edu	37	6	32093899	32093899	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr6:32093899G>T	ENST00000375201.4	-	5	509	c.464C>A	c.(463-465)tCc>tAc	p.S155Y	ATF6B_ENST00000375203.3_Missense_Mutation_p.S158Y|ATF6B_ENST00000468502.1_5'UTR			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	158					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.S158Y(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						ATTACCTGAGGAATCATCAGA	0.507000													42	81					5.7616e-29	7.81932e-29	0.014410	1	0
ADAMTS19	171019	broad.mit.edu	37	5	128983512	128983512	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr5:128983512G>A	ENST00000274487.4	+	12	2054	c.1909G>A	c.(1909-1911)Gga>Aga	p.G637R	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	637	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.G637R(2)		NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		ACATCTGGCCGGAGAGTGGAG	0.522000													55	27					0	0	0.014410	0	0
FOXC1	2296	broad.mit.edu	37	6	1611154	1611154	+	Silent	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr6:1611154C>T	ENST00000380874.2	+	1	474	c.474C>T	c.(472-474)tcC>tcT	p.S158S		NM_001453.2	NP_001444.2	Q12948	FOXC1_HUMAN	forkhead box C1	158					anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding	p.S158S(2)		large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	8	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		ACCCGGACTCCTACAACATGT	0.627000													8	38					0	0	0.003080	0	0
AC015849.16	0	broad.mit.edu	37	17	34233423	34233423	+	RNA	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr17:34233423G>A	ENST00000587132.1	-	0	4604																											ATGGTGAAATGTTGGAGGCTG	0.468000													10	9					0	0	0.006214	0	0
VARS	7407	broad.mit.edu	37	6	31752254	31752254	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr6:31752254C>T	ENST00000375663.3	-	12	1933	c.1493G>A	c.(1492-1494)cGc>cAc	p.R498H	VARS_ENST00000444930.2_Missense_Mutation_p.R203H	NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	498					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity	p.R498H(2)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	GAGCAGGGTGCGACCTGTCAG	0.597000													25	56					0	0	0.006320	0	0
CDH5	1003	broad.mit.edu	37	16	66436911	66436911	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr16:66436911G>A	ENST00000341529.3	+	12	2342	c.2194G>A	c.(2194-2196)Ggc>Agc	p.G732S	CDH5_ENST00000539168.1_Missense_Mutation_p.G171S	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	732					adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding	p.G732S(1)		central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		GCACATCTACGGCTACGAGGG	0.642000													11	19					0	0	0.010729	0	0
ADRBK1	156	broad.mit.edu	37	11	67052768	67052768	+	Silent	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr11:67052768G>A	ENST00000308595.5	+	21	2207	c.1917G>A	c.(1915-1917)gaG>gaA	p.E639E	ADRBK1_ENST00000526285.1_Intron	NM_001619.3	NP_001610.2	P25098	ARBK1_HUMAN	adrenergic, beta, receptor kinase 1	639	PH.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity	p.E639E(2)		cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)	22			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GCGACCCTGAGCTGGTGCAGT	0.697000													21	31					0	0	0.010504	0	0
RASAL1	8437	broad.mit.edu	37	12	113544983	113544983	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr12:113544983G>T	ENST00000546530.1	-	16	1864	c.1579C>A	c.(1579-1581)Ccc>Acc	p.P527T	RASAL1_ENST00000261729.5_Missense_Mutation_p.P526T|RASAL1_ENST00000446861.3_Missense_Mutation_p.P526T|RASAL1_ENST00000548055.1_Missense_Mutation_p.P526T|RASAL1_ENST00000418411.2_5'UTR	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	526					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity	p.P526T(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						GGGTGCAGGGGGGCCATCCAC	0.622000													18	30					2.48551e-13	3.29474e-13	0.004990	1	0
PIPSL	0	broad.mit.edu	37	10	95718641	95718641	+	RNA	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr10:95718641C>T	ENST00000480546.1	-	0	2656					NR_002319.2																						CACAGCATTTCGAATGGCTTC	0.542000													10	62					0	0	0.006214	0	0
RIPK1	8737	broad.mit.edu	37	6	3077128	3077128	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr6:3077128A>G	ENST00000259808.4	+	2	369	c.71A>G	c.(70-72)gAc>gGc	p.D24G	RIPK1_ENST00000380409.2_Missense_Mutation_p.D24G|RIPK1_ENST00000479389.1_Intron|RIPK1_ENST00000541791.1_Missense_Mutation_p.D24G			Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine kinase 1	24	Protein kinase.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity	p.D24G(2)		breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	23	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				GCAGAACTGGACAGCGGAGGC	0.478000													8	49					0	0	0.003080	0	0
PRKCSH	5589	broad.mit.edu	37	19	11552168	11552168	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr19:11552168A>G	ENST00000252455.2	+	6	800	c.464A>G	c.(463-465)aAg>aGg	p.K155R	PRKCSH_ENST00000587327.1_Missense_Mutation_p.K155R|PRKCSH_ENST00000589838.1_Missense_Mutation_p.K155R|PRKCSH_ENST00000412601.1_Missense_Mutation_p.K155R|PRKCSH_ENST00000592741.1_Missense_Mutation_p.K155R|PRKCSH_ENST00000591462.1_Missense_Mutation_p.K155R	NM_002743.2	NP_002734.2	P14314	GLU2B_HUMAN	protein kinase C substrate 80K-H	155					innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding	p.K155R(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(3)	19						CGGGAGGAGAAGCAGGTAAGG	0.612000													52	113					0	0	0.014410	0	0
FAT1	2195	broad.mit.edu	37	4	187540359	187540359	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr4:187540359A>G	ENST00000441802.2	-	10	7590	c.7381T>C	c.(7381-7383)Tac>Cac	p.Y2461H		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2461	Cadherin 22.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding	p.Y2461H(2)|p.Y2464H(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TTAAGACTGTAAAATGGCTTC	0.443000										HNSCC(5;0.00058)			6	234					0	0	0.001168	0	0
CSMD3	114788	broad.mit.edu	37	8	113529332	113529332	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr8:113529332C>T	ENST00000297405.5	-	28	4931	c.4687G>A	c.(4687-4689)Gag>Aag	p.E1563K	CSMD3_ENST00000352409.3_Missense_Mutation_p.E1563K|CSMD3_ENST00000343508.3_Missense_Mutation_p.E1523K|CSMD3_ENST00000455883.2_Missense_Mutation_p.E1459K	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1563	Sushi 8.					integral to membrane|plasma membrane		p.E1563K(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATTCTTTCCTCTCCTTGAAGT	0.438000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			32	66					0	0	0.009535	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28315754	28315754	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr21:28315754C>A	ENST00000284987.5	-	3	1471	c.1350G>T	c.(1348-1350)aaG>aaT	p.K450N		NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	450	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding	p.K450N(2)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						TGGACCAGGGCTTAGATGCAT	0.448000													4	34					0.00024832	0.000301154	0.009096	1	0
ARHGEF15	22899	broad.mit.edu	37	17	8221715	8221715	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr17:8221715G>A	ENST00000361926.3	+	10	1825	c.1715G>A	c.(1714-1716)cGc>cAc	p.R572H	AC135178.7_ENST00000458568.1_RNA|ARHGEF15_ENST00000421050.1_Missense_Mutation_p.R572H	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	572	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.R572H(1)		breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						AATATCCTGCGCCAGACAGAA	0.627000													47	84					0	0	0.014410	0	0
SEPHS1	22929	broad.mit.edu	37	10	13375855	13375855	+	Silent	SNP	T	T	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr10:13375855T>C	ENST00000327347.5	-	5	897	c.522A>G	c.(520-522)ggA>ggG	p.G174G	SEPHS1_ENST00000537130.1_Silent_p.G107G|SEPHS1_ENST00000378614.4_Silent_p.G174G|SEPHS1_ENST00000545675.1_Silent_p.G174G	NM_001195602.1|NM_012247.4	NP_001182531.1|NP_036379.2	P49903	SPS1_HUMAN	selenophosphate synthetase 1	174					protein modification process		ATP binding|GTP binding|selenide, water dikinase activity	p.G174G(2)		cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|stomach(1)	16						TGGTAGCCACTCCTCCCAGGA	0.438000													16	28					0	0	0.004990	0	0
FRG1B	0	broad.mit.edu	37	20	29628236	29628236	+	Missense_Mutation	SNP	G	G	C	rs145412486	by1000genomes	TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr20:29628236G>C	ENST00000278882.3	+	6	618	c.238G>C	c.(238-240)Gct>Cct	p.A80P	FRG1B_ENST00000358464.4_Missense_Mutation_p.A80P|FRG1B_ENST00000439954.2_Missense_Mutation_p.A85P														p.A80P(8)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGGAAAATGGCTTTGTTGGC	0.363000													3	84					0	0	0.009096	0	0
FRG1B	0	broad.mit.edu	37	20	29628251	29628251	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr20:29628251A>G	ENST00000278882.3	+	6	633	c.253A>G	c.(253-255)Aat>Gat	p.N85D	FRG1B_ENST00000358464.4_Missense_Mutation_p.N85D|FRG1B_ENST00000439954.2_Missense_Mutation_p.N90D														p.N85D(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTTGGCCTCAAATAGCTGCTT	0.358000													5	77					0	0	0.001168	0	0
OR4C3	256144	broad.mit.edu	37	11	48347071	48347071	+	Missense_Mutation	SNP	C	C	A	rs138317832		TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr11:48347071C>A	ENST00000319856.4	+	1	600	c.579C>A	c.(577-579)ttC>ttA	p.F193L		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	166					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F193L(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						GGTTGCCCTTCTGTGGGCCCA	0.532000													23	63					1.96895e-08	2.55068e-08	0.002780	1	0
OR4D9	390199	broad.mit.edu	37	11	59282589	59282589	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr11:59282589T>G	ENST00000329328.3	+	1	204	c.204T>G	c.(202-204)atT>atG	p.I68M		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I68M(1)		endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						ACCTGTCTATTCTTGACATCT	0.443000													79	123					0	0	0.014410	0	0
SNAP25	6616	broad.mit.edu	37	20	10273562	10273562	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr20:10273562C>G	ENST00000304886.2	+	5	404	c.196C>G	c.(196-198)Cat>Gat	p.H66D	SNAP25-AS1_ENST00000421143.2_RNA|SNAP25-AS1_ENST00000453544.1_RNA|SNAP25_ENST00000254976.2_Intron	NM_003081.3	NP_003072.2	P60880	SNP25_HUMAN	synaptosomal-associated protein, 25kDa	66	Interaction with CENPF (By similarity).|t-SNARE coiled-coil homology 1.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome		p.H66D(1)		endometrium(1)|large_intestine(2)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	18					Botulinum Toxin Type A(DB00083)	AGGCATGAACCATATCAACCA	0.413000													12	84					0	0	0.013537	0	0
AGBL1	123624	broad.mit.edu	37	15	86838596	86838596	+	Silent	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr15:86838596G>A	ENST00000441037.2	+	16	2288	c.2193G>A	c.(2191-2193)acG>acA	p.T731T	AGBL1_ENST00000389298.3_Silent_p.T462T|AGBL1_ENST00000421325.2_Silent_p.T731T	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	731					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding	p.T731T(1)		NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TGACCATCACGGCCATGCCTG	0.498000													37	68					0	0	0.007835	0	0
HCN4	10021	broad.mit.edu	37	15	73615456	73615456	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr15:73615456G>T	ENST00000261917.3	-	8	3971	c.2978C>A	c.(2977-2979)aCg>aAg	p.T993K		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	993	Pro-rich.				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity	p.T993K(1)		NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		TGTCTCTGGCGTGCTCAGTGG	0.697000													7	13					0.000157383	0.000199352	0.003080	1	0
DPT	1805	broad.mit.edu	37	1	168698284	168698284	+	Silent	SNP	C	C	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr1:168698284C>T	ENST00000367817.3	-	1	218	c.129G>A	c.(127-129)cgG>cgA	p.R43R		NM_001937.4	NP_001928.2	Q07507	DERM_HUMAN	dermatopontin	43	2 X 53-55 AA tandem repeats.				cell adhesion	extracellular space|proteinaceous extracellular matrix		p.R43R(1)		kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)	12	all_hematologic(923;0.208)					TGAAGCCTTGCCGGTTCAAAT	0.542000													4	64					0	0	0.009096	0	0
HPS1	3257	broad.mit.edu	37	10	100177455	100177455	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr10:100177455G>A	ENST00000325103.6	-	20	2202	c.1969C>T	c.(1969-1971)Cgc>Tgc	p.R657C	HPS1_ENST00000467246.1_5'UTR|HPS1_ENST00000361490.4_Missense_Mutation_p.R657C	NM_000195.3	NP_000186.2	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1	657					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity	p.R657C(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		TCGGTTGGGCGGTTCTTGCTG	0.662000									Hermansky-Pudlak syndrome				21	31					0	0	0.003330	0	0
LIMK1	3984	broad.mit.edu	37	7	73498339	73498339	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr7:73498339T>G	ENST00000336180.2	+	1	70	c.19T>G	c.(19-21)Tgt>Ggt	p.C7G	LIMK1_ENST00000418310.1_Intron	NM_002314.3	NP_002305.1	P53667	LIMK1_HUMAN	LIM domain kinase 1	7					actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				GACGCTACTTTGTTGCACCTG	0.776000													4	5					0	0	0.009096	0	0
MALAT1	0	broad.mit.edu	37	11	65269936	65269936	+	RNA	SNP	A	A	T			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr11:65269936A>T	ENST00000534336.1	+	0	4704					NR_002819.2																						TCCATTGTTTAACTGCAAAAC	0.264000													10	23					0	0	0.006214	0	0
TBX19	9095	broad.mit.edu	37	1	168278015	168278015	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr1:168278015G>C	ENST00000367821.3	+	7	1003	c.952G>C	c.(952-954)Gtt>Ctt	p.V318L	TBX19_ENST00000465440.1_3'UTR	NM_005149.2	NP_005140.1	O60806	TBX19_HUMAN	T-box 19	318					anatomical structure morphogenesis	nucleus	DNA binding	p.V318L(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(11)|prostate(2)|skin(2)|urinary_tract(1)	34	all_hematologic(923;0.215)					TAATCTGCAAGTTTTCTCGGG	0.463000													3	92					0	0	0.004672	0	0
RP11-33N16.3	0	broad.mit.edu	37	14	90203668	90203668	+	RNA	DEL	C	C	-	rs67505159		TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr14:90203668delC	ENST00000555070.1	-	0	170																											CTCTTTCTTTCtttttttttt	0.368													3	6	---	---	---	---					
DNM1P47	0	broad.mit.edu	37	15	102292874	102292876	+	RNA	DEL	CTC	CTC	-			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	23c4ade3-dc70-4bd0-95f0-c7be9eec4d99	g.chr15:102292874_102292876delCTC	ENST00000561463.1	+	0	920_922																											AGTTCATCTTCTCAGAGCTGCTG	0.581													2	4	---	---	---	---					
AC027612.3	0	broad.mit.edu	37	2	91899626	91899626	+	RNA	DEL	A	A	-			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr2:91899626delA	ENST00000436174.1	-	0	168																											CCAGAGGCTCAAAAAAAAAAA	0.289													4	5	---	---	---	---					
PRSS3P2	0	broad.mit.edu	37	7	142481923	142481925	+	RNA	DEL	CAA	CAA	-			TCGA-G9-6332-01A-11D-1786-08	TCGA-G9-6332-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	50f0a6a4-1453-4dc2-b963-53a6075ce4cd	c92e4a08-8313-44d3-98b2-07d089ae97ff	g.chr7:142481923_142481925delCAA	ENST00000603901.1	+	0	591					NR_001296.3																						GTGATTAGACCAACCCTTCCCAT	0.537													7	80	---	---	---	---