Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CD3D	915	broad.mit.edu	37	11	118209902	118209902	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr11:118209902C>T	ENST00000300692.4	-	5	627	c.491G>A	c.(490-492)gGa>gAa	p.G164E	CD3D_ENST00000529594.1_Missense_Mutation_p.G91E|CD3D_ENST00000392884.2_Missense_Mutation_p.G120E	NM_000732.4	NP_000723.1	P04234	CD3D_HUMAN	CD3d molecule, delta (CD3-TCR complex)	164	ITAM.				positive thymic T cell selection|T cell costimulation|T cell receptor signaling pathway	cytoplasm|integral to membrane	protein heterodimerization activity			large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)	9	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		CCAGTTTCCTCCAAGGTGGCT	0.507000													27	37					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110984838	110984838	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr8:110984838C>T	ENST00000524391.1	-	3	1672	c.640G>A	c.(640-642)Gtc>Atc	p.V214I	KCNV1_ENST00000297404.1_Missense_Mutation_p.V214I			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	214						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity	p.V214I(1)		breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			ATGGAGATGACGCCAAAGATA	0.517000													31	24					0	0	1	0	0
ZNF700	90592	broad.mit.edu	37	19	12060277	12060277	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr19:12060277G>C	ENST00000482090.1	+	3	1802	c.1384G>C	c.(1384-1386)Ggg>Cgg	p.G462R	ZNF763_ENST00000591944.1_Intron|ZNF700_ENST00000254321.5_Missense_Mutation_p.G480R|ZNF763_ENST00000590798.1_Intron|CTD-2006C1.12_ENST00000586394.1_RNA|ZNF763_ENST00000538752.1_Intron			Q9H0M5	ZN700_HUMAN	zinc finger protein 700	480					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		ZNF700/MAST1_ENST00000251472(2)	breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	33						TAAGGAATGTGGGAAAGCCTT	0.408000													31	49					0	0	1	0	0
SPARC	6678	broad.mit.edu	37	5	151045995	151045995	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr5:151045995C>T	ENST00000231061.4	-	8	974	c.661G>A	c.(661-663)Gag>Aag	p.E221K	SPARC_ENST00000537849.1_5'UTR	NM_003118.3	NP_003109.1	P09486	SPRC_HUMAN	secreted protein, acidic, cysteine-rich (osteonectin)	221					ossification|platelet activation|platelet degranulation|signal transduction	basement membrane|extracellular space|platelet alpha granule lumen	calcium ion binding|collagen binding	p.E221K(1)		central_nervous_system(3)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	15		Medulloblastoma(196;0.109)|all_hematologic(541;0.122)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;0.00118)	Becaplermin(DB00102)	TAGTTCTTCTCGAAGTCCCGG	0.557000													5	49					0	0	1	0	0
MSI2	0	broad.mit.edu	37	17	55752422	55752422	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr17:55752422G>A	ENST00000284073.2	+	12	1089	c.880G>A	c.(880-882)Gga>Aga	p.G294R	MSI2_ENST00000442934.2_Missense_Mutation_p.G233R|MSI2_ENST00000416426.2_Missense_Mutation_p.G290R	NM_138962.2	NP_620412.1	Q96DH6	MSI2H_HUMAN	musashi RNA-binding protein 2	294						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	7	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		CCAGGACTCCGGAGTGGGGAA	0.692000			T	HOXA9	CML								30	45					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237666715	237666715	+	Silent	SNP	G	G	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr1:237666715G>A	ENST00000366574.2	+	22	2840	c.2523G>A	c.(2521-2523)aaG>aaA	p.K841K	RYR2_ENST00000542537.1_Silent_p.K825K|RYR2_ENST00000360064.6_Silent_p.K839K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	841					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAGAGTACAAGCAAGAAAGAA	0.493000													4	53					0	0	1	0	0
SNX33	257364	broad.mit.edu	37	15	75942239	75942239	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr15:75942239C>T	ENST00000308527.5	+	1	1993	c.796C>T	c.(796-798)Cgc>Tgc	p.R266C		NM_153271.1	NP_695003.1	Q8WV41	SNX33_HUMAN	sorting nexin 33	266	PX.				cell communication		phosphatidylinositol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|soft_tissue(1)|urinary_tract(2)	19						CGTCTACCGGCGCTACAAACA	0.552000													22	57					0	0	1	0	0
EMILIN2	84034	broad.mit.edu	37	18	2892375	2892375	+	Silent	SNP	G	G	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr18:2892375G>A	ENST00000254528.3	+	4	2409	c.2250G>A	c.(2248-2250)tcG>tcA	p.S750S		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	750					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		CGCTCAGGTCGCATTCCAGAG	0.483000													28	27					0	0	1	0	0
HRH4	59340	broad.mit.edu	37	18	22057269	22057269	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr18:22057269G>T	ENST00000256906.4	+	3	1016	c.916G>T	c.(916-918)Gcc>Tcc	p.A306S	HRH4_ENST00000426880.2_Missense_Mutation_p.A218S	NM_001160166.1|NM_021624.3	NP_001153638.1|NP_067637.2	Q9H3N8	HRH4_HUMAN	histamine receptor H4	306						integral to membrane|plasma membrane	histamine receptor activity	p.A306S(1)		endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	CAAGTCACTGGCCATTCTCTT	0.438000													63	88					5.80444e-35	6.44937e-35	1	1	0
KSR1	8844	broad.mit.edu	37	17	25877722	25877722	+	Silent	SNP	G	G	A	rs56367532	by1000genomes	TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr17:25877722G>A	ENST00000319524.6	+	2	360	c.360G>A	c.(358-360)ccG>ccA	p.P120P	KSR1_ENST00000268763.6_5'UTR|KSR1_ENST00000398988.3_5'UTR|KSR1_ENST00000509603.2_Silent_p.P120P			Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	118					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		ACGTGAGGCCGGAGGTGGTGC	0.607000													11	27					0	0	1	0	0
AMDHD1	144193	broad.mit.edu	37	12	96359480	96359480	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr12:96359480G>A	ENST00000266736.2	+	7	1061	c.955G>A	c.(955-957)Gcc>Acc	p.A319T		NM_152435.2	NP_689648.2	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1	319					histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|skin(1)	22						ACAACCTCGAGCCAGGAAGAT	0.383000													27	48					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18875186	18875186	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr7:18875186C>T	ENST00000406451.3	+	20	2704	c.2554C>T	c.(2554-2556)Cct>Tct	p.P852S	HDAC9_ENST00000401921.1_Missense_Mutation_p.P811S|HDAC9_ENST00000441542.2_Missense_Mutation_p.P855S|HDAC9_ENST00000432645.2_Missense_Mutation_p.P852S	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	852	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	GAACTTTTTCCCTGGCAGTGG	0.443000													15	21					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55111560	55111560	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr11:55111560C>T	ENST00000314721.2	+	1	934	c.884C>T	c.(883-885)gCt>gTt	p.A295V		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						ATGAAAAATGCTATGAAAAAT	0.318000													14	13					0	0	1	0	0
TUBB4A	10382	broad.mit.edu	37	19	6495339	6495339	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr19:6495339G>A	ENST00000264071.2	-	4	1542	c.1171C>T	c.(1171-1173)Cgc>Tgc	p.R391C	TUBB4A_ENST00000540257.1_Missense_Mutation_p.R391C			P04350	TBB4_HUMAN	tubulin, beta 4A class IVa	391					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity	p.R391C(1)									AAGGCCTTGCGCCGGAACATG	0.612000													50	119					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108427560	108427560	+	Splice_Site	SNP	G	G	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr10:108427560G>A	ENST00000263054.6	-	17	2197	c.2189_splice	c.e17-1	p.C730_splice	SORCS1_ENST00000344440.6_Splice_Site_p.C730_splice|SORCS1_ENST00000369698.1_Splice_Site_p.C265_splice	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	730						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AACCATAGTCGCTGTTAGGAA	0.453000													7	21					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								5	56					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237774130	237774130	+	Silent	SNP	G	G	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr1:237774130G>A	ENST00000366574.2	+	36	5069	c.4752G>A	c.(4750-4752)ccG>ccA	p.P1584P	RYR2_ENST00000542537.1_Silent_p.P1568P|RYR2_ENST00000360064.6_Silent_p.P1582P	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1584	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGTGCCCCCCGCGCCTCCACG	0.537000													6	11					0	0	1	0	0
P2RX4	5025	broad.mit.edu	37	12	121647993	121647993	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr12:121647993C>T	ENST00000337233.4	+	1	334	c.26C>T	c.(25-27)gCg>gTg	p.A9V	P2RX4_ENST00000543171.1_5'UTR|P2RX4_ENST00000540930.1_3'UTR|P2RX4_ENST00000359949.7_Missense_Mutation_p.A9V|P2RX4_ENST00000541532.1_Missense_Mutation_p.A9V	NM_001261397.1|NM_001261398.1|NM_002560.2	NP_001248326.1|NP_001248327.1|NP_002551.2	Q99571	P2RX4_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 4	9					endothelial cell activation|negative regulation of cardiac muscle hypertrophy|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|regulation of apoptosis|regulation of blood pressure|regulation of sodium ion transport|relaxation of cardiac muscle|response to ATP|response to fluid shear stress|sensory perception of pain|tissue homeostasis	cell junction|perinuclear region of cytoplasm	cadherin binding|copper ion binding|extracellular ATP-gated cation channel activity|protein homodimerization activity|purinergic nucleotide receptor activity|receptor binding|zinc ion binding			breast(1)|kidney(4)|large_intestine(4)|lung(7)|prostate(1)	17	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GCCGCGCTGGCGGCCTTCCTG	0.716000													4	12					0	0	1	0	0
SRR	63826	broad.mit.edu	37	17	2222193	2222193	+	Silent	SNP	G	G	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr17:2222193G>A	ENST00000344595.5	+	4	687	c.369G>A	c.(367-369)gcG>gcA	p.A123A	SRR_ENST00000576848.1_Intron	NM_021947.1	NP_068766.1	Q9GZT4	SRR_HUMAN	serine racemase	123					D-serine biosynthetic process|L-serine metabolic process|protein homotetramerization|pyruvate biosynthetic process|response to lipopolysaccharide	cytoplasm|neuronal cell body|soluble fraction	ATP binding|calcium ion binding|D-serine ammonia-lyase activity|glycine binding|L-serine ammonia-lyase activity|magnesium ion binding|PDZ domain binding|protein homodimerization activity|pyridoxal phosphate binding|serine racemase activity|threonine racemase activity			NS(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	8		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;3.24e-06)|READ - Rectum adenocarcinoma(1115;0.0649)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	CCTACGGAGCGTCAATTGTAT	0.453000													6	138					0	0	1	0	0
MRPS22	56945	broad.mit.edu	37	3	139071544	139071544	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr3:139071544G>A	ENST00000495075.1	+	8	1220	c.788G>A	c.(787-789)cGt>cAt	p.R263H	MRPS22_ENST00000310776.4_Missense_Mutation_p.R263H|MRPS22_ENST00000465056.1_Missense_Mutation_p.R262H|MRPS22_ENST00000478464.1_Missense_Mutation_p.R222H			P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	263						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	12						GACCTTTTACGTTCAACAAGA	0.323000													4	50					0	0	1	0	0
RMDN1	51115	broad.mit.edu	37	8	87486552	87486552	+	Silent	SNP	G	G	A	rs150282224	by1000genomes	TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr8:87486552G>A	ENST00000406452.3	-	10	1089	c.930C>T	c.(928-930)ttC>ttT	p.F310F	RMDN1_ENST00000430676.2_Silent_p.F280F|RMDN1_ENST00000519966.1_Silent_p.F267F|RMDN1_ENST00000523911.1_Intron	NM_016033.2	NP_057117.2			regulator of microtubule dynamics 1																		TCTTCTCACTGAAACTTGTAA	0.289000													66	33					0	0	1	0	0
SASS6	163786	broad.mit.edu	37	1	100586957	100586957	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr1:100586957C>A	ENST00000287482.5	-	5	600	c.460G>T	c.(460-462)Gca>Tca	p.A154S	SASS6_ENST00000462159.1_5'UTR|SASS6_ENST00000535161.1_5'UTR	NM_194292.1	NP_919268.1	Q6UVJ0	SAS6_HUMAN	spindle assembly 6 homolog (C. elegans)	154					centriole replication	centriole				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	19		all_epithelial(167;4.58e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.085)|all cancers(265;0.139)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.197)		AAACAGCCTGCGAGAAATTTC	0.294000													14	36					3.27435e-08	3.48335e-08	1	1	0
PCDHB2	0	broad.mit.edu	37	5	140475698	140475698	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr5:140475698C>A	ENST00000194155.4	+	1	1472	c.1324C>A	c.(1324-1326)Ctg>Atg	p.L442M		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		442	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CATAACCGTGCTGGTCTCCGA	0.607000													4	158					1	1	1	1	0
RPL10L	140801	broad.mit.edu	37	14	47120583	47120583	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr14:47120583A>C	ENST00000298283.3	-	1	445	c.357T>G	c.(355-357)ttT>ttG	p.F119L		NM_080746.2	NP_542784.1	Q96L21	RL10L_HUMAN	ribosomal protein L10-like	119					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(20)|ovary(1)	27						GGGGTTTTCCAAAGGCACCTC	0.552000													15	21					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235922371	235922371	+	Missense_Mutation	SNP	C	C	T	rs147791378		TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr1:235922371C>T	ENST00000389794.3	-	23	6956	c.6782G>A	c.(6781-6783)cGt>cAt	p.R2261H	LYST_ENST00000389793.2_Missense_Mutation_p.R2261H			Q99698	LYST_HUMAN	lysosomal trafficking regulator	2261					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ACTTGGCCAACGGCCAACAGC	0.478000													13	28					0	0	1	0	0
HADH	3033	broad.mit.edu	37	4	108954337	108954337	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr4:108954337G>A	ENST00000505878.1	+	8	1000	c.727G>A	c.(727-729)Gca>Aca	p.A243T	HADH_ENST00000309522.3_Missense_Mutation_p.A239T|HADH_ENST00000603302.1_Missense_Mutation_p.A256T|HADH_ENST00000403312.1_Missense_Mutation_p.A315T|HADH_ENST00000454409.2_Missense_Mutation_p.A243T|HADH_ENST00000510728.1_3'UTR			Q16836	HCDH_HUMAN	hydroxyacyl-CoA dehydrogenase	239					fatty acid beta-oxidation	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|NAD+ binding	p.A239T(1)		endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	15		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000168)	NADH(DB00157)	CTTAGGTGACGCATCCAAAGA	0.453000													33	37					0	0	1	0	0
SLC24A1	9187	broad.mit.edu	37	15	65917689	65917689	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr15:65917689C>T	ENST00000261892.6	+	2	1558	c.1271C>T	c.(1270-1272)cCc>cTc	p.P424L	SLC24A1_ENST00000537259.1_Missense_Mutation_p.P424L|SLC24A1_ENST00000399033.4_Missense_Mutation_p.P424L|SLC24A1_ENST00000339868.6_Missense_Mutation_p.P424L|SLC24A1_ENST00000546330.1_Missense_Mutation_p.P424L|SLC24A1_ENST00000544319.2_Missense_Mutation_p.P424L	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	424					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						AGTCCTAGTCCCTCAGTGCTG	0.632000													18	40					0	0	1	0	0
RP11-19N8.2	0	broad.mit.edu	37	16	33013847	33013847	+	RNA	SNP	T	T	C			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr16:33013847T>C	ENST00000567619.1	-	0	499																											GGGGCCTCAGTGAAGGTCTCC	0.592000													15	101					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	34					0	0	1	0	0
SOAT2	8435	broad.mit.edu	37	12	53499389	53499389	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr12:53499389G>A	ENST00000301466.3	+	4	380	c.320G>A	c.(319-321)cGc>cAc	p.R107H		NM_003578.3	NP_003569.1	O75908	SOAT2_HUMAN	sterol O-acyltransferase 2	107					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			endometrium(5)|kidney(3)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|skin(1)	18						TTCATCATCCGCAAGTCCCTG	0.507000													3	47					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578443	7578443	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr17:7578443A>G	ENST00000420246.2	-	5	619	c.487T>C	c.(487-489)Tac>Cac	p.Y163H	TP53_ENST00000269305.4_Missense_Mutation_p.Y163H|TP53_ENST00000445888.2_Missense_Mutation_p.Y163H|TP53_ENST00000359597.4_Missense_Mutation_p.Y163H|TP53_ENST00000455263.2_Missense_Mutation_p.Y163H|TP53_ENST00000413465.2_Missense_Mutation_p.Y163H	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	163	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y163N(20)|p.Y163H(17)|p.0?(8)|p.Y163D(5)|p.I162_Y163>N(3)|p.Y163fs*7(2)|p.V157_C176del20(1)|p.Y163fs*1(1)|p.Y163_Q165delYKQ(1)|p.P151_V173del23(1)|p.S149fs*72(1)|p.I30_Y31>N(1)|p.I162_Y163delIY(1)|p.I69_Y70>N(1)|p.Y70N(1)|p.A161fs*7(1)|p.Y31N(1)|p.Y163fs*14(1)|p.A159_Q167delAMAIYKQSQ(1)|p.Y163fs*18(1)|p.Y70D(1)|p.Y31D(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GACTGCTTGTAGATGGCCATG	0.622000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	23					0	0	1	0	0
KRT6B	3854	broad.mit.edu	37	12	52843383	52843383	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr12:52843383G>A	ENST00000252252.3	-	5	994	c.947C>T	c.(946-948)aCa>aTa	p.T316I		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	316	Linker 12.|Rod.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		CACCACGGATGTGTCTGAGAT	0.522000													12	101					0	0	1	0	0
CFHR4	10877	broad.mit.edu	37	1	196874338	196874338	+	Silent	SNP	A	A	G			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr1:196874338A>G	ENST00000367416.2	+	3	491	c.354A>G	c.(352-354)ccA>ccG	p.P118P	CFHR2_ENST00000367421.3_Intron|CFHR4_ENST00000367418.1_Intron|CFHR4_ENST00000251424.4_Intron	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						ATTGTAAACCAGGATATGCAA	0.299000													32	61					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36872645	36872645	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr3:36872645C>A	ENST00000301807.6	-	21	8544	c.6647G>T	c.(6646-6648)tGt>tTt	p.C2216F	TRANK1_ENST00000428977.2_Missense_Mutation_p.C2216F|TRANK1_ENST00000429976.2_Missense_Mutation_p.C2766F	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2766					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CCTCTCCTGACACTCCTCCCT	0.547000													8	84					3.09899e-07	3.22811e-07	1	1	0
CERCAM	51148	broad.mit.edu	37	9	131196779	131196779	+	Silent	SNP	G	G	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr9:131196779G>A	ENST00000372842.1	+	12	4332	c.1188G>A	c.(1186-1188)acG>acA	p.T396T	CERCAM_ENST00000372838.4_Silent_p.T474T			Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule	474					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				endometrium(2)|kidney(4)|large_intestine(2)|lung(9)|ovary(1)|pancreas(2)	20						CCTACTGGACGCTGGCCTATG	0.662000													24	32					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71485738	71485738	+	Silent	SNP	C	C	T			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr14:71485738C>T	ENST00000304743.2	+	12	3455	c.3009C>T	c.(3007-3009)atC>atT	p.I1003I	PCNX_ENST00000238570.5_Silent_p.I1003I|PCNX_ENST00000439984.3_Silent_p.I892I	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	1003						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		ATCGTGAGATCCTGGAAAATG	0.373000													43	78					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12885289	12885289	+	Silent	SNP	G	G	T	rs148273194	by1000genomes	TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr1:12885289G>T	ENST00000535591.1	-	4	1017	c.822C>A	c.(820-822)ctC>ctA	p.L274L		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	274								p.L274L(3)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GGCACTGGGAGAGATGCTTCA	0.458000													6	207					8.12818e-05	8.29407e-05	1	1	0
CYLC1	1538	broad.mit.edu	37	X	83129065	83129065	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chrX:83129065C>T	ENST00000329312.4	+	4	1386	c.1349C>T	c.(1348-1350)cCg>cTg	p.P450L		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	450					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						GACTCTGAACCGAAGGGAGAT	0.338000													9	3					0	0	1	0	0
MYL12A	10627	broad.mit.edu	37	18	3255826	3255826	+	Silent	SNP	C	C	T			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr18:3255826C>T	ENST00000217652.3	+	4	821	c.426C>T	c.(424-426)taC>taT	p.Y142Y	MYL12A_ENST00000536605.1_Silent_p.Y142Y|MYL12A_ENST00000578611.1_Silent_p.Y142Y|MYL12A_ENST00000579226.1_Silent_p.Y142Y|RP13-270P17.1_ENST00000578800.1_RNA|MYL12A_ENST00000580887.1_Silent_p.Y148Y|RP13-270P17.1_ENST00000581905.1_RNA	NM_006471.2	NP_006462.1	P19105	ML12A_HUMAN	myosin, light chain 12A, regulatory, non-sarcomeric	142	EF-hand 3.					myosin complex	calcium ion binding|protein binding			NS(1)|kidney(2)|large_intestine(2)	5						ATGAGCTGTACAGAGAAGCAC	0.423000													8	24					0	0	1	0	0
GTPBP1	9567	broad.mit.edu	37	22	39112791	39112791	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr22:39112791G>A	ENST00000216044.5	+	4	853	c.620G>A	c.(619-621)cGc>cAc	p.R207H		NM_004286.4	NP_004277.2	O00178	GTPB1_HUMAN	GTP binding protein 1	207					immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	18	Melanoma(58;0.04)					GAATCTGGTCGCACCAGCAGT	0.567000													13	41					0	0	1	0	0
SSTR1	0	broad.mit.edu	37	14	38679324	38679324	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr14:38679324G>A	ENST00000267377.2	+	3	1347	c.730G>A	c.(730-732)Gtg>Atg	p.V244M		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	244					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	CCTGTGCTACGTGCTCATCAT	0.597000													8	29					0	0	1	0	0
OR5D14	219436	broad.mit.edu	37	11	55563060	55563060	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr11:55563060T>C	ENST00000335605.1	+	1	29	c.29T>C	c.(28-30)aTg>aCg	p.M10T		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				AATCTGAGCATGGAGCCCACC	0.403000													51	89					0	0	1	0	0
ERN1	2081	broad.mit.edu	37	17	62133144	62133144	+	Silent	SNP	C	C	T			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr17:62133144C>T	ENST00000433197.2	-	13	1658	c.1563G>A	c.(1561-1563)tcG>tcA	p.S521S		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	521					activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						TGCTGGTGCCCGAGCTCTCTG	0.682000													3	7					0	0	1	0	0
RP11-182I10.3	0	broad.mit.edu	37	1	65451792	65451793	+	RNA	INS	-	-	T	rs113756498		TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr1:65451792_65451793insT	ENST00000447748.1	-	0	1775																											CAATCTAATTGttttttttttt	0.490													5	9	---	---	---	---					
OSBPL10	114884	broad.mit.edu	37	3	31774769	31774769	+	Frame_Shift_Del	DEL	T	T	-			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr3:31774769delT	ENST00000396556.2	-	6	1197	c.1075delA	c.(1075-1077)ccfs	p.T359fs	OSBPL10_ENST00000467647.1_5'UTR|OSBPL10_ENST00000438237.2_Frame_Shift_Del_p.T295fs	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	359					lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		GGCTGTGAGGTTTGTTCGTCT	0.448													28	70	---	---	---	---					
PMS2CL	0	broad.mit.edu	37	7	6760766	6760766	+	RNA	DEL	G	G	-			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr7:6760766delG	ENST00000486256.1	+	0	346					NR_002217.1																						CCATCTCTCTGTCCTCACAAC	0.517													7	4	---	---	---	---					
CCT6P3	0	broad.mit.edu	37	7	64532708	64532709	+	RNA	INS	-	-	A			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr7:64532708_64532709insA	ENST00000426828.1	+	0	1228					NR_033416.1																						AAATGGGGACCAAAAAAAAAAA	0.351													2	4	---	---	---	---					
INTS8	55656	broad.mit.edu	37	8	95844240	95844240	+	Frame_Shift_Del	DEL	T	T	-			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr8:95844240delT	ENST00000523731.1	+	6	724	c.591delT	c.(589-591)gafs	p.D197fs	INTS8_ENST00000447247.1_Frame_Shift_Del_p.D197fs	NM_017864.2	NP_060334.2	Q75QN2	INT8_HUMAN	integrator complex subunit 8	197					snRNA processing	integrator complex	protein binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	28	Breast(36;1.05e-06)					AAGCTGCTGATTCTATTTTGG	0.313													47	32	---	---	---	---					
TRAV9-2	0	broad.mit.edu	37	14	22409540	22409541	+	RNA	INS	-	-	C			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr14:22409540_22409541insC	ENST00000390441.2	+	0	102																											tctctctctctTTTTTTTTTTC	0.426													2	4	---	---	---	---					
PIEZO1	9780	broad.mit.edu	37	16	88800373	88800375	+	In_Frame_Del	DEL	TCC	TCC	-	rs59446030		TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr16:88800373_88800375delTCC	ENST00000301015.9	-	17	2514_2516	c.2268_2270delGGA	c.(2266-2271)gac>ga	p.ED756del	RP5-1142A6.2_ENST00000440406.2_RNA	NM_001142864.2	NP_001136336.2	Q92508	PIEZ1_HUMAN	piezo-type mechanosensitive ion channel component 1	756						endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to membrane|plasma membrane	ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|prostate(2)|skin(1)	10						GTCCCTGGAGtcctcctcctcct	0.685													2	4	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr17:45219612delA	ENST00000066544.3	-	11	1454	c.1361delT	c.(1360-1362)cafs	p.L454fs	CDC27_ENST00000446365.2_Frame_Shift_Del_p.L393fs|CDC27_ENST00000527547.1_Frame_Shift_Del_p.L454fs|CDC27_ENST00000531206.1_Frame_Shift_Del_p.L460fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	454					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308													8	46	---	---	---	---					
ZNF682	91120	broad.mit.edu	37	19	20117285	20117293	+	In_Frame_Del	DEL	TTTATAGGG	TTTATAGGG	-			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr19:20117285_20117293delTTTATAGGG	ENST00000397165.2	-	4	1178_1186	c.1018_1026delCCCTATAAA	c.(1018-1026)del	p.PYK340del	ZNF682_ENST00000397162.1_In_Frame_Del_p.PYK308del|ZNF682_ENST00000597972.1_In_Frame_Del_p.PYK346del|ZNF682_ENST00000596019.1_Intron|ZNF682_ENST00000595736.1_In_Frame_Del_p.PYK264del|ZNF682_ENST00000358523.5_In_Frame_Del_p.PYK308del	NM_033196.2	NP_149973.1	O95780	ZN682_HUMAN	zinc finger protein 682	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	14						ATTCTTCACATTTATAGGGTTTCTCTCCC	0.378													15	66	---	---	---	---					
CLDND2	125875	broad.mit.edu	37	19	51871170	51871170	+	Frame_Shift_Del	DEL	G	G	-			TCGA-G9-A9S4-01A-11D-A41K-08	TCGA-G9-A9S4-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d36ef053-e634-4711-9ee4-dac20b166856	3aac36e8-fe99-4218-9fb8-dba6dd6ea066	g.chr19:51871170delG	ENST00000291715.1	-	2	705	c.280delC	c.(280-282)agfs	p.Q94fs	CTD-2616J11.11_ENST00000600067.1_Frame_Shift_Del_p.Q29fs|CLDND2_ENST00000601435.1_Frame_Shift_Del_p.Q94fs	NM_152353.2	NP_689566.1	Q8NHS1	CLDN2_HUMAN	claudin domain containing 2	94						integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)	4		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CTCGTGGTCTGGCCCCGCAGC	0.716													7	12	---	---	---	---