Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF208	7757	broad.mit.edu	37	19	22155896	22155896	+	Missense_Mutation	SNP	A	A	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr19:22155896A>C	ENST00000397126.4	-	4	2088	c.1940T>G	c.(1939-1941)aTt>aGt	p.I647S	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGAGACCTTAATAAAGGTTTT	0.398000													5	87					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66460020	66460020	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr11:66460020T>C	ENST00000533211.1	-	26	5508	c.5177A>G	c.(5176-5178)tAc>tGc	p.Y1726C	SPTBN2_ENST00000529997.1_Missense_Mutation_p.Y1726C|SPTBN2_ENST00000309996.2_Missense_Mutation_p.Y1726C			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1726					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						CACATGCTCGTAGTCCTGGCC	0.647000													3	109					0	0	1	0	0
USP35	57558	broad.mit.edu	37	11	77924826	77924826	+	Silent	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr11:77924826C>T	ENST00000529308.1	+	11	3285	c.3024C>T	c.(3022-3024)ggC>ggT	p.G1008G	USP35_ENST00000530267.1_Silent_p.G576G|USP35_ENST00000530535.1_3'UTR|USP35_ENST00000526425.1_Silent_p.G739G|USP35_ENST00000441408.2_Silent_p.G594G	NM_020798.2	NP_065849.1	Q9P2H5	UBP35_HUMAN	ubiquitin specific peptidase 35	1008					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(3)|urinary_tract(1)	23	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			CTGCAGGTGGCAATGGTGGTG	0.582000													4	74					0	0	1	0	0
ASMT	438	broad.mit.edu	37	X	1755354	1755354	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chrX:1755354C>T	ENST00000381241.3	+	8	1010	c.811C>T	c.(811-813)Ccg>Tcg	p.P271S	ASMT_ENST00000381229.4_Missense_Mutation_p.P243S|ASMT_ENST00000381233.3_Missense_Mutation_p.P196S|RP13-297E16.3_ENST00000509780.1_RNA	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	243					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGACCCTCTTCCGGAAGCTGA	0.542000													17	267					0	0	1	0	0
FADS1	3992	broad.mit.edu	37	11	61574167	61574167	+	Silent	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr11:61574167C>T	ENST00000350997.7	-	6	1177	c.945G>A	c.(943-945)ccG>ccA	p.P315P	FADS1_ENST00000542506.1_Silent_p.P174P|FADS2_ENST00000574708.1_Intron|FADS1_ENST00000433932.1_Silent_p.P174P	NM_013402.4	NP_037534.3	O60427	FADS1_HUMAN	fatty acid desaturase 1	258					cell-cell signaling|cellular response to starvation|electron transport chain|icosanoid biosynthetic process|phospholipid biosynthetic process|regulation of cell differentiation|regulation of transcription, DNA-dependent|transport	endoplasmic reticulum membrane|integral to membrane|microsome	C-5 sterol desaturase activity|heme binding|protein binding			central_nervous_system(1)|endometrium(1)|lung(1)|urinary_tract(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GGTGGTTGTACGGCATATATT	0.483000													20	110					0	0	1	0	0
PRKG2	5593	broad.mit.edu	37	4	82064095	82064095	+	Silent	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr4:82064095G>A	ENST00000395578.1	-	11	1376	c.1260C>T	c.(1258-1260)tcC>tcT	p.S420S	PRKG2_ENST00000264399.1_Silent_p.S420S|PRKG2_ENST00000418486.2_Silent_p.S420S|PRKG2_ENST00000545647.1_5'UTR|PRKG2_ENST00000509169.1_5'UTR			Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	420					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			NS(1)|breast(4)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	37						AGTTAGACATGGACCGCCTGT	0.438000													13	69					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625875	29625875	+	Missense_Mutation	SNP	T	T	C	rs143761036	by1000genomes	TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr20:29625875T>C	ENST00000278882.3	+	5	499	c.119T>C	c.(118-120)aTc>aCc	p.I40T	FRG1B_ENST00000358464.4_Missense_Mutation_p.I40T|FRG1B_ENST00000439954.2_Missense_Mutation_p.I45T														p.I40T(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGTACAGAATCGCCCTGAAA	0.358000													6	58					0	0	1	0	0
SLC25A26	115286	broad.mit.edu	37	3	66428192	66428192	+	Silent	SNP	G	G	A	rs147162139		TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr3:66428192G>A	ENST00000354883.6	+	11	1514	c.786G>A	c.(784-786)acG>acA	p.T262T	SLC25A26_ENST00000336733.5_Silent_p.T174T|SLC25A26_ENST00000536651.1_3'UTR			Q70HW3	SAMC_HUMAN	solute carrier family 25 (S-adenosylmethionine carrier), member 26	262						integral to membrane|mitochondrial inner membrane|nucleus	S-adenosylmethionine transmembrane transporter activity			endometrium(1)|large_intestine(1)|lung(2)|pancreas(1)|stomach(2)|urinary_tract(1)	8		Lung NSC(201;0.00774)		BRCA - Breast invasive adenocarcinoma(55;0.00046)|KIRC - Kidney renal clear cell carcinoma(15;0.0515)|Kidney(15;0.0648)		ATGACCGAACGCACAGCTTGC	0.502000													4	198					0	0	1	0	0
ZNF785	146540	broad.mit.edu	37	16	30594188	30594188	+	Missense_Mutation	SNP	C	C	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr16:30594188C>A	ENST00000395216.2	-	3	1070	c.911G>T	c.(910-912)cGc>cTc	p.R304L	AC002310.7_ENST00000492040.1_RNA|AC002310.7_ENST00000486926.1_RNA|ZNF785_ENST00000470110.1_Missense_Mutation_p.R289L	NM_152458.6	NP_689671.2	A8K8V0	ZN785_HUMAN	zinc finger protein 785	304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	9						GGTGTGTATGCGCCTGTGGAT	0.647000													3	47					0.000602214	0.00061967	1	1	0
TEX15	56154	broad.mit.edu	37	8	30701810	30701810	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr8:30701810G>A	ENST00000256246.2	-	1	4798	c.4724C>T	c.(4723-4725)aCg>aTg	p.T1575M		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1575										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TAAAATAGGCGTATGATTAAC	0.388000													9	104					0	0	1	0	0
MMP14	4323	broad.mit.edu	37	14	23312555	23312555	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr14:23312555T>C	ENST00000311852.6	+	5	1039	c.778T>C	c.(778-780)Ttt>Ctt	p.F260L	MMP14_ENST00000548162.1_3'UTR	NM_004995.2	NP_004986.1	P50281	MMP14_HUMAN	matrix metallopeptidase 14 (membrane-inserted)	260						extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	20	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		CATGGCACCCTTTTACCAGTG	0.587000													4	166					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23527693	23527693	+	Silent	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr5:23527693T>C	ENST00000296682.3	+	11	2678	c.2496T>C	c.(2494-2496)taT>taC	p.Y832Y		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	832					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding	p.Y832Y(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AGAAGCCCTATGTCTGCAGGG	0.587000										HNSCC(3;0.000094)			3	158					0	0	1	0	0
EIF3M	10480	broad.mit.edu	37	11	32610273	32610273	+	Silent	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr11:32610273G>A	ENST00000531120.1	+	3	372	c.309G>A	c.(307-309)ctG>ctA	p.L103L	EIF3M_ENST00000524896.1_Intron	NM_006360.4	NP_006351.2	Q7L2H7	EIF3M_HUMAN	eukaryotic translation initiation factor 3, subunit M	103						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16	Breast(20;0.109)					CTCTGAGACTGCAGTTGTAAG	0.408000													4	122					0	0	1	0	0
ANKDD1A	348094	broad.mit.edu	37	15	65234714	65234714	+	Missense_Mutation	SNP	G	G	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr15:65234714G>T	ENST00000380230.3	+	10	947	c.918G>T	c.(916-918)ttG>ttT	p.L306F	ANKDD1A_ENST00000395723.1_Missense_Mutation_p.L215F|ANKDD1A_ENST00000357698.3_Missense_Mutation_p.L306F|ANKDD1A_ENST00000395720.1_Missense_Mutation_p.L306F	NM_182703.3	NP_874362.3	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	306					signal transduction					NS(1)|endometrium(1)|large_intestine(10)|liver(2)|lung(4)|ovary(1)|prostate(2)	21						TCCCTGCCTTGGTCCGGCTCC	0.602000													3	42					0.0215528	0.0218607	1	1	0
STT3A	3703	broad.mit.edu	37	11	125472775	125472775	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr11:125472775G>A	ENST00000392708.4	+	5	508	c.349G>A	c.(349-351)Gtg>Atg	p.V117M	STT3A_ENST00000531491.1_Missense_Mutation_p.V25M|STT3A_ENST00000529196.1_Missense_Mutation_p.V117M	NM_001278503.1|NM_001278504.1|NM_152713.3	NP_001265432.1|NP_001265433.1|NP_689926.1	P46977	STT3A_HUMAN	STT3A, subunit of the oligosaccharyltransferase complex (catalytic)	117					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity			NS(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(15)|skin(1)	33	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)		GAATGTCTGTGTGTTCCTGGC	0.488000													22	55					0	0	1	0	0
SCRN2	90507	broad.mit.edu	37	17	45916217	45916217	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr17:45916217G>A	ENST00000407215.3	-	5	793	c.712C>T	c.(712-714)Cgc>Tgc	p.R238C	SCRN2_ENST00000290216.9_Missense_Mutation_p.R238C|SCRN2_ENST00000584123.1_Missense_Mutation_p.R246C			Q96FV2	SCRN2_HUMAN	secernin 2	238					proteolysis		dipeptidase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	14						GCCTCCATGCGCACAGGCTGC	0.672000													5	136					0	0	1	0	0
QRICH1	54870	broad.mit.edu	37	3	49094329	49094329	+	Missense_Mutation	SNP	T	T	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr3:49094329T>G	ENST00000395443.2	-	3	1776	c.1304A>C	c.(1303-1305)cAg>cCg	p.Q435P	QRICH1_ENST00000357496.2_Missense_Mutation_p.Q435P|QRICH1_ENST00000479449.1_5'UTR|QRICH1_ENST00000424300.1_Missense_Mutation_p.Q435P	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	435	Gln-rich.									breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		ctgctgctgctgtggtggtgg	0.562000													3	66					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47296303	47296303	+	Silent	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr11:47296303G>A	ENST00000342922.4	+	3	609	c.252G>A	c.(250-252)aaG>aaA	p.K84K	MADD_ENST00000395344.3_Silent_p.K84K|MADD_ENST00000349238.3_Silent_p.K84K|MADD_ENST00000311027.5_Silent_p.K84K|MADD_ENST00000407859.3_Silent_p.K84K|MADD_ENST00000402799.1_Silent_p.K84K|MADD_ENST00000406482.1_Silent_p.K84K|MADD_ENST00000402192.2_Silent_p.K84K|MADD_ENST00000395336.3_Silent_p.K84K	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	84	UDENN.				activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		TCACTGACAAGGACACTGGAG	0.567000													3	135					0	0	1	0	0
OR11H4	390442	broad.mit.edu	37	14	20711208	20711208	+	Silent	SNP	C	C	T	rs150420661		TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr14:20711208C>T	ENST00000315409.2	+	1	311	c.258C>T	c.(256-258)tcC>tcT	p.S86S		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	86					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		ATGTGTCCTCCACTATTCCTA	0.453000													5	166					0	0	1	0	0
FGF5	2250	broad.mit.edu	37	4	81207627	81207627	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr4:81207627G>A	ENST00000312465.7	+	3	834	c.608G>A	c.(607-609)aGc>aAc	p.S203N	FGF5_ENST00000503413.1_3'UTR|FGF5_ENST00000456523.3_3'UTR	NM_004464.3	NP_004455.2	P12034	FGF5_HUMAN	fibroblast growth factor 5	203					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22						CGAGGGTGCAGCCCCCGGGTT	0.473000													3	91					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	24105528	24105528	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr16:24105528T>C	ENST00000303531.7	+	7	883	c.731T>C	c.(730-732)aTt>aCt	p.I244T	PRKCB_ENST00000321728.7_Missense_Mutation_p.I244T|PRKCB_ENST00000482000.1_3'UTR	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	244	C2.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	TCAGTAGAGATTTGGGATTGG	0.418000													17	52					0	0	1	0	0
LINC00264	0	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													5	42					0	0	1	0	0
CLGN	1047	broad.mit.edu	37	4	141317054	141317054	+	Silent	SNP	A	A	G	rs145850842	by1000genomes	TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr4:141317054A>G	ENST00000325617.5	-	10	1508	c.1068T>C	c.(1066-1068)ggT>ggC	p.G356G	CLGN_ENST00000414773.1_Silent_p.G356G|CLGN_ENST00000537281.1_Silent_p.G356G	NM_004362.2	NP_004353.1	O14967	CLGN_HUMAN	calmegin	356					protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(5)|ovary(2)|prostate(3)|skin(4)|urinary_tract(1)	25	all_hematologic(180;0.162)					GTTTCCACTCACCACACCCAA	0.433000													3	63					0	0	1	0	0
OR10J1	26476	broad.mit.edu	37	1	159410187	159410187	+	Missense_Mutation	SNP	T	T	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr1:159410187T>G	ENST00000423932.3	+	1	676	c.639T>G	c.(637-639)agT>agG	p.S213R	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	213					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					TGATTATCAGTGTGCTGGTGC	0.458000													20	106					0	0	1	0	0
EXOC8	149371	broad.mit.edu	37	1	231471575	231471575	+	Silent	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr1:231471575C>T	ENST00000366645.1	-	1	2023	c.1905G>A	c.(1903-1905)ctG>ctA	p.L635L	EXOC8_ENST00000360394.2_Silent_p.L639L			Q8IYI6	EXOC8_HUMAN	exocyst complex component 8	639					exocytosis|protein transport	growth cone|nucleus	protein binding			cervix(2)|endometrium(1)|large_intestine(2)|liver(1)|lung(5)|prostate(1)|skin(1)|stomach(1)	14	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				GTACCATGTGCAGCTCTGGGA	0.478000													13	77					0	0	1	0	0
MTMR4	9110	broad.mit.edu	37	17	56585536	56585536	+	Silent	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr17:56585536G>A	ENST00000323456.5	-	8	775	c.651C>T	c.(649-651)ccC>ccT	p.P217P	MTMR4_ENST00000579925.1_Silent_p.P217P	NM_004687.4	NP_004678.3	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	217	Myotubularin phosphatase.					cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			breast(10)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|skin(5)	36	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ACACAACCACGGGAATCCGCT	0.522000													33	82					0	0	1	0	0
MIR329-1	0	broad.mit.edu	37	14	101493161	101493161	+	RNA	SNP	A	A	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr14:101493161A>T	ENST00000385028.1	+	0	40					NR_029967.1																						TGTTTCTTTAATGAGGACGAA	0.468000													5	128					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414280	20414280	+	Silent	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr9:20414280G>A	ENST00000380338.4	-	5	850	c.564C>T	c.(562-564)agC>agT	p.S188S	MLLT3_ENST00000429426.2_Silent_p.S185S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	188	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S188S(1)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TGGTActactgctgctgctgc	0.502000			T	MLL	ALL								5	71					0	0	1	0	0
NNT	23530	broad.mit.edu	37	5	43700278	43700278	+	Silent	SNP	T	T	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr5:43700278T>G	ENST00000264663.5	+	20	3155	c.2934T>G	c.(2932-2934)gcT>gcG	p.A978A	NNT_ENST00000512996.2_Silent_p.A847A|NNT_ENST00000344920.4_Silent_p.A978A	NM_012343.3	NP_036475.3	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	978					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(7)|large_intestine(6)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(6;2.58e-06)				NADH(DB00157)	TGCTGCTGGCTGAGGCTGGTG	0.453000													26	85					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51774158	51774158	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr6:51774158T>C	ENST00000371117.3	-	40	6880	c.6605A>G	c.(6604-6606)aAg>aGg	p.K2202R	PKHD1_ENST00000340994.4_Missense_Mutation_p.K2202R	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	2202					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CTGCACTCCCTTCAACTGGAC	0.532000													3	185					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276981	186276981	+	Silent	SNP	A	A	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr1:186276981A>G	ENST00000445192.2	+	7	2175	c.2130A>G	c.(2128-2130)aaA>aaG	p.K710K	PRG4_ENST00000367486.3_Silent_p.K667K|PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367485.4_Silent_p.K617K|PRG4_ENST00000367483.4_Silent_p.K669K	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	710	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CTACCCCTAAAGGGACTGCTC	0.582000													5	103					0	0	1	0	0
HEATR1	55127	broad.mit.edu	37	1	236749185	236749185	+	Missense_Mutation	SNP	G	G	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr1:236749185G>T	ENST00000366582.3	-	16	2098	c.1984C>A	c.(1984-1986)Cag>Aag	p.Q662K	HEATR1_ENST00000366581.2_Missense_Mutation_p.Q662K	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	662					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ATCATCTTCTGATTTGCTACA	0.363000													3	43					1	1	1	1	0
ACTC1	70	broad.mit.edu	37	15	35085746	35085746	+	Missense_Mutation	SNP	T	T	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr15:35085746T>G	ENST00000290378.4	-	3	809	c.154A>C	c.(154-156)Aag>Cag	p.K52Q	RP11-814P5.1_ENST00000503496.1_RNA	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	52					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		TAGGAGTCCTTCTGACCCATA	0.453000													5	27					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37617884	37617884	+	Silent	SNP	C	C	T	rs112487012		TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr21:37617884C>T	ENST00000399151.3	+	19	3691	c.3606C>T	c.(3604-3606)ctC>ctT	p.L1202L		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	1202					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						ACTTGGAGCTCCAGGCCCTCA	0.622000													4	35					0	0	1	0	0
DENND5B	160518	broad.mit.edu	37	12	31586051	31586051	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr12:31586051G>A	ENST00000354285.4	-	9	2389	c.2210C>T	c.(2209-2211)gCg>gTg	p.A737V	DENND5B_ENST00000306833.6_Intron|DENND5B_ENST00000389082.5_Intron|DENND5B_ENST00000536562.1_Intron			Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	0						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						AGTTCATGGCGCTTGCTGTGA	0.433000													3	77					0	0	1	0	0
ZNF780A	284323	broad.mit.edu	37	19	40580582	40580582	+	Silent	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr19:40580582C>T	ENST00000450241.2	-	6	1976	c.1665G>A	c.(1663-1665)gaG>gaA	p.E555E	ZNF780A_ENST00000594395.1_Silent_p.E590E|ZNF780A_ENST00000455521.1_Silent_p.E590E|ZNF780A_ENST00000414720.2_Intron|ZNF780A_ENST00000340963.5_Silent_p.E589E|ZNF780A_ENST00000595687.2_Silent_p.E589E|AC005614.5_ENST00000595508.1_RNA			O75290	Z780A_HUMAN	zinc finger protein 780A	589					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|upper_aerodigestive_tract(3)|urinary_tract(1)	31	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CTTTCCCACACTCCTTACATT	0.393000													5	174					0	0	1	0	0
CPN1	1369	broad.mit.edu	37	10	101835675	101835675	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr10:101835675G>A	ENST00000370418.3	-	2	664	c.413C>T	c.(412-414)gCt>gTt	p.A138V		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	138	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		TACCTGGGCAGCAGCCACCTC	0.567000													3	48					0	0	1	0	0
DPY19L2	283417	broad.mit.edu	37	12	64041106	64041106	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr12:64041106T>C	ENST00000324472.4	-	5	811	c.628A>G	c.(628-630)Atg>Gtg	p.M210V	RP11-415I12.3_ENST00000509615.2_RNA	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	210					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		AATAAATTCATTATTCCCATG	0.318000													4	110					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr1:145367767G>A	ENST00000342960.5	+	83	10398	c.10363G>A	c.(10363-10365)Gaa>Aaa	p.E3455K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3455								p.E3455K(5)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.423000													3	43					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90162555	90162555	+	RNA	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr16:90162555C>T	ENST00000564451.1	+	0	1908				TUBB8P7_ENST00000567960.1_RNA																							ATGCCACGGCCGAGGAGGAGG	0.522000													3	122					0	0	1	0	0
FSCN3	29999	broad.mit.edu	37	7	127235557	127235557	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr7:127235557G>A	ENST00000265825.5	+	2	560	c.341G>A	c.(340-342)cGt>cAt	p.R114H	FSCN3_ENST00000420086.2_5'UTR	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	114						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging	p.R114H(1)		endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						ATCTCTGGTCGTTATTTGGAG	0.567000													3	57					0	0	1	0	0
CLEC1B	51266	broad.mit.edu	37	12	10147815	10147815	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr12:10147815G>A	ENST00000428126.2	-	6	639	c.370C>T	c.(370-372)Cgt>Tgt	p.R124C	CLEC1B_ENST00000348658.4_Missense_Mutation_p.R124C|CLEC1B_ENST00000298527.6_Missense_Mutation_p.R157C			Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B	157	C-type lectin.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity	p.R157C(1)|p.?(1)		NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(12)|stomach(1)|urinary_tract(1)	19						CCGACCCAACGAATTAAATGA	0.418000													51	267					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122774732	122774732	+	Silent	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr11:122774732G>A	ENST00000227349.2	+	3	741	c.444G>A	c.(442-444)ccG>ccA	p.P148P	C11orf63_ENST00000307257.6_Silent_p.P148P|C11orf63_ENST00000531316.1_Silent_p.P148P	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	148										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		AAGCGTTGCCGGAGTCCACGG	0.532000													3	118					0	0	1	0	0
ANKRD32	84250	broad.mit.edu	37	5	94022425	94022425	+	Splice_Site	SNP	T	T	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr5:94022425T>G	ENST00000265140.5	+	16	2540		c.e16+2			NM_032290.3	NP_115666.2	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32											NS(1)|breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|skin(1)	13		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		CAGAAAATGGTAAGTACCTCT	0.363000													14	67					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167277926	167277926	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr3:167277926C>T	ENST00000308378.3	-	5	882	c.577G>A	c.(577-579)Gca>Aca	p.A193T	WDR49_ENST00000479765.1_Intron|WDR49_ENST00000453925.2_Missense_Mutation_p.A246T|WDR49_ENST00000476376.1_Missense_Mutation_p.A18T	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	193										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						CTGATTTCTGCGTTGCCGTGG	0.453000													18	96					0	0	1	0	0
CSRNP3	80034	broad.mit.edu	37	2	166514412	166514412	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr2:166514412G>A	ENST00000314499.7	+	5	666	c.290G>A	c.(289-291)cGc>cAc	p.R97H	CSRNP3_ENST00000342316.4_Missense_Mutation_p.R97H|CSRNP3_ENST00000409420.1_Missense_Mutation_p.R129H	NM_001172173.1	NP_001165644.1	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	97					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.R97H(1)		breast(2)|cervix(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(3)|skin(2)	33						ATGTCCAGCCGCCATAACAGC	0.547000													3	46					0	0	1	0	0
HIST1H4B	8366	broad.mit.edu	37	6	26027359	26027359	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr6:26027359C>T	ENST00000377364.3	-	1	121	c.122G>A	c.(121-123)cGt>cAt	p.R41H		NM_003544.2	NP_003535.1	P62805	H4_HUMAN	histone cluster 1, H4b	41					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			large_intestine(4)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	13						AACCCCACCACGCCTAGCAAG	0.552000													4	62					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282808	152282808	+	Silent	SNP	A	A	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr1:152282808A>G	ENST00000368799.1	-	3	4589	c.4554T>C	c.(4552-4554)caT>caC	p.H1518H	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1518	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGGCTGTGATGGTACCCTG	0.562000									Ichthyosis				62	383					0	0	1	0	0
MESP1	55897	broad.mit.edu	37	15	90293435	90293435	+	Silent	SNP	A	A	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr15:90293435A>C	ENST00000300057.4	-	2	825	c.747T>G	c.(745-747)gcT>gcG	p.A249A	MESP1_ENST00000559894.1_5'UTR	NM_018670.3	NP_061140.1	Q9BRJ9	MESP1_HUMAN	mesoderm posterior 1 homolog (mouse)	249					cardiac atrium formation|cardiac cell fate determination|cardiac vascular smooth muscle cell differentiation|cardiac ventricle formation|cardioblast anterior-lateral migration|cardioblast migration to the midline involved in heart field formation|endothelial cell differentiation|gastrulation|growth involved in heart morphogenesis|heart looping|lateral mesoderm development|negative regulation of endodermal cell fate specification|negative regulation of mesodermal cell fate specification|negative regulation of transcription, DNA-dependent|neurogenesis|Notch signaling pathway|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|positive regulation of hepatocyte differentiation|positive regulation of Notch signaling pathway|positive regulation of striated muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|secondary heart field specification|sinoatrial node cell differentiation|sinus venosus morphogenesis		sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(1)|kidney(1)	2	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			TCTCCAACAGAGCCAGCACGT	0.647000													11	73					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38810577	38810577	+	Missense_Mutation	SNP	A	A	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr6:38810577A>T	ENST00000359357.3	+	33	4346	c.4092A>T	c.(4090-4092)agA>agT	p.R1364S	DNAH8_ENST00000449981.2_Missense_Mutation_p.R1581S|DNAH8_ENST00000441566.1_Missense_Mutation_p.R1364S					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ACTGGGATAGAATCTCCGAGT	0.383000													24	99					0	0	1	0	0
ABCE1	6059	broad.mit.edu	37	4	146032204	146032204	+	Missense_Mutation	SNP	A	A	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr4:146032204A>C	ENST00000296577.4	+	8	1213	c.698A>C	c.(697-699)cAg>cCg	p.Q233P	OTUD4_ENST00000455611.2_5'UTR|ABCE1_ENST00000502803.1_Intron	NM_001040876.1|NM_002940.2	NP_001035809.1|NP_002931.2	P61221	ABCE1_HUMAN	ATP-binding cassette, sub-family E (OABP), member 1	233	ABC transporter 1.				interspecies interaction between organisms|response to virus|RNA catabolic process	mitochondrion	ATP binding|ATPase activity|electron carrier activity|iron-sulfur cluster binding|ribonuclease inhibitor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|lung(5)|prostate(2)|skin(3)	18	all_hematologic(180;0.151)					GTTTGCATACAGAAAGCTGAT	0.363000													6	69					0	0	1	0	0
HTR2C	3358	broad.mit.edu	37	X	113965800	113965800	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chrX:113965800C>T	ENST00000276198.1	+	4	861	c.133C>T	c.(133-135)Cgc>Tgc	p.R45C	HTR2C_ENST00000371951.1_Missense_Mutation_p.R45C|HTR2C_ENST00000371950.3_Missense_Mutation_p.R45C	NM_000868.2	NP_000859.1	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	45					cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	CGATGGTGGACGCTTCAAATT	0.443000													25	75					0	0	1	0	0
ELAVL2	1993	broad.mit.edu	37	9	23701423	23701423	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr9:23701423T>C	ENST00000397312.2	-	5	941	c.667A>G	c.(667-669)Aac>Gac	p.N223D	ELAVL2_ENST00000544538.1_Missense_Mutation_p.N223D|ELAVL2_ENST00000380110.4_Missense_Mutation_p.N252D|ELAVL2_ENST00000380117.1_Missense_Mutation_p.N223D|ELAVL2_ENST00000223951.6_Missense_Mutation_p.N223D	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	223					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TACCTTCTGTTTGGAGACTGG	0.488000													32	224					0	0	1	0	0
GPR4	2828	broad.mit.edu	37	19	46095073	46095073	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr19:46095073G>A	ENST00000323040.4	-	2	996	c.52C>T	c.(52-54)Ctc>Ttc	p.L18F	OPA3_ENST00000544371.1_Intron	NM_005282.2	NP_005273.1	P46093	GPR4_HUMAN	G protein-coupled receptor 4	18						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		GGCGGAAAGAGGTGGTCCACG	0.672000													10	59					0	0	1	0	0
PHTF1	10745	broad.mit.edu	37	1	114256026	114256026	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr1:114256026T>C	ENST00000369604.1	-	8	1141	c.658A>G	c.(658-660)Act>Gct	p.T220A	PHTF1_ENST00000447664.2_Intron|PHTF1_ENST00000369596.2_Missense_Mutation_p.T167A|PHTF1_ENST00000393357.2_Missense_Mutation_p.T220A|PHTF1_ENST00000369598.1_Missense_Mutation_p.T175A|PHTF1_ENST00000357783.2_Missense_Mutation_p.T220A|PHTF1_ENST00000474926.1_5'UTR|PHTF1_ENST00000369600.1_Missense_Mutation_p.T167A			Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1	220						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCAGTTTCAGTCCCTTTGTTA	0.318000													3	24					0	0	1	0	0
ZNF658	26149	broad.mit.edu	37	9	40773282	40773282	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr9:40773282T>C	ENST00000602553.1	-	5	2287	c.1993A>G	c.(1993-1995)Aga>Gga	p.R665G	ZNF658_ENST00000377626.3_Missense_Mutation_p.R665G|ZNF658_ENST00000441795.1_Intron			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	665					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GTGAAAGATCTCCCACATTCA	0.403000													3	156					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887686	12887686	+	Silent	SNP	T	T	C	rs59802947	by1000genomes	TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr1:12887686T>C	ENST00000535591.1	-	3	366	c.171A>G	c.(169-171)agA>agG	p.R57R		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	57								p.R57R(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GAAGTTTCCATCTCCTGTGGG	0.468000													3	219					0	0	1	0	0
EHHADH	1962	broad.mit.edu	37	3	184936017	184936017	+	Missense_Mutation	SNP	A	A	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr3:184936017A>C	ENST00000231887.3	-	5	550	c.475T>G	c.(475-477)Tta>Gta	p.L159V	EHHADH_ENST00000475987.1_5'UTR|EHHADH_ENST00000456310.1_Missense_Mutation_p.L63V	NM_001166415.1|NM_001966.3	NP_001159887.1|NP_001957.2	Q08426	ECHP_HUMAN	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	159	Enoyl-CoA hydratase / isomerase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(2)|skin(3)	24	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	TCATCTGCTAAAATACGTCTT	0.378000													29	104					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52883592	52883592	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr4:52883592G>A	ENST00000343457.3	-	1	194	c.188C>T	c.(187-189)gCc>gTc	p.A63V		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	63						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						ATCCACAGTGGCTGCTGTCTG	0.353000													5	42					0	0	1	0	0
CYP2W1	54905	broad.mit.edu	37	7	1024635	1024635	+	Silent	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr7:1024635G>A	ENST00000340150.6	+	3	241	c.219G>A	c.(217-219)acG>acA	p.T73T	CYP2W1_ENST00000308919.7_Silent_p.T129T			Q8TAV3	CP2W1_HUMAN	cytochrome P450, family 2, subfamily W, polypeptide 1	129					xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		GCCAGTTCACGGTGCGTGCCC	0.652000													9	60					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71346978	71346978	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr4:71346978T>C	ENST00000413702.1	+	4	805	c.517T>C	c.(517-519)Tct>Cct	p.S173P	MUC7_ENST00000514512.1_3'UTR|MUC7_ENST00000304887.5_Missense_Mutation_p.S173P|MUC7_ENST00000456088.1_Missense_Mutation_p.S173P	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	173	Thr-rich.					extracellular region	protein binding	p.S173P(3)		central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			ACCCACACCTTCTGCAACTAC	0.522000													3	145					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128351136	128351136	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr2:128351136C>T	ENST00000389524.4	+	18	2214	c.2161C>T	c.(2161-2163)Cgc>Tgc	p.R721C	MYO7B_ENST00000409816.2_Missense_Mutation_p.R721C|MYO7B_ENST00000428314.1_Missense_Mutation_p.R721C			Q6PIF6	MYO7B_HUMAN	myosin VIIB	721	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		AGGCAAGCTCCGCCAGATGAC	0.612000													3	115					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22155896	22155896	+	Missense_Mutation	SNP	A	A	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr19:22155896A>C	ENST00000397126.4	-	4	2088	c.1940T>G	c.(1939-1941)aTt>aGt	p.I647S	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGAGACCTTAATAAAGGTTTT	0.398000													5	87					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66460020	66460020	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr11:66460020T>C	ENST00000533211.1	-	26	5508	c.5177A>G	c.(5176-5178)tAc>tGc	p.Y1726C	SPTBN2_ENST00000309996.2_Missense_Mutation_p.Y1726C|SPTBN2_ENST00000529997.1_Missense_Mutation_p.Y1726C			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1726					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						CACATGCTCGTAGTCCTGGCC	0.647000													3	109					0	0	1	0	0
USP35	57558	broad.mit.edu	37	11	77924826	77924826	+	Silent	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr11:77924826C>T	ENST00000529308.1	+	11	3285	c.3024C>T	c.(3022-3024)ggC>ggT	p.G1008G	USP35_ENST00000526425.1_Silent_p.G739G|USP35_ENST00000441408.2_Silent_p.G594G|USP35_ENST00000530535.1_3'UTR|USP35_ENST00000530267.1_Silent_p.G576G	NM_020798.2	NP_065849.1	Q9P2H5	UBP35_HUMAN	ubiquitin specific peptidase 35	1008					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(3)|urinary_tract(1)	23	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			CTGCAGGTGGCAATGGTGGTG	0.582000													4	74					0	0	1	0	0
FADS1	3992	broad.mit.edu	37	11	61574167	61574167	+	Silent	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr11:61574167C>T	ENST00000350997.7	-	6	1177	c.945G>A	c.(943-945)ccG>ccA	p.P315P	FADS1_ENST00000433932.1_Silent_p.P174P|FADS1_ENST00000542506.1_Silent_p.P174P|FADS2_ENST00000574708.1_Intron	NM_013402.4	NP_037534.3	O60427	FADS1_HUMAN	fatty acid desaturase 1	258					cell-cell signaling|cellular response to starvation|electron transport chain|icosanoid biosynthetic process|phospholipid biosynthetic process|regulation of cell differentiation|regulation of transcription, DNA-dependent|transport	endoplasmic reticulum membrane|integral to membrane|microsome	C-5 sterol desaturase activity|heme binding|protein binding			central_nervous_system(1)|endometrium(1)|lung(1)|urinary_tract(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GGTGGTTGTACGGCATATATT	0.483000													20	110					0	0	1	0	0
PRKG2	5593	broad.mit.edu	37	4	82064095	82064095	+	Silent	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr4:82064095G>A	ENST00000395578.1	-	11	1376	c.1260C>T	c.(1258-1260)tcC>tcT	p.S420S	PRKG2_ENST00000509169.1_5'UTR|PRKG2_ENST00000264399.1_Silent_p.S420S|PRKG2_ENST00000545647.1_5'UTR|PRKG2_ENST00000418486.2_Silent_p.S420S			Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	420					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			NS(1)|breast(4)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	37						AGTTAGACATGGACCGCCTGT	0.438000													13	69					0	0	1	0	0
SLC25A26	115286	broad.mit.edu	37	3	66428192	66428192	+	Silent	SNP	G	G	A	rs147162139		TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr3:66428192G>A	ENST00000354883.6	+	11	1514	c.786G>A	c.(784-786)acG>acA	p.T262T	SLC25A26_ENST00000336733.5_Silent_p.T174T|SLC25A26_ENST00000536651.1_3'UTR			Q70HW3	SAMC_HUMAN	solute carrier family 25 (S-adenosylmethionine carrier), member 26	262						integral to membrane|mitochondrial inner membrane|nucleus	S-adenosylmethionine transmembrane transporter activity			endometrium(1)|large_intestine(1)|lung(2)|pancreas(1)|stomach(2)|urinary_tract(1)	8		Lung NSC(201;0.00774)		BRCA - Breast invasive adenocarcinoma(55;0.00046)|KIRC - Kidney renal clear cell carcinoma(15;0.0515)|Kidney(15;0.0648)		ATGACCGAACGCACAGCTTGC	0.502000													4	198					0	0	1	0	0
ZNF785	146540	broad.mit.edu	37	16	30594188	30594188	+	Missense_Mutation	SNP	C	C	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr16:30594188C>A	ENST00000395216.2	-	3	1070	c.911G>T	c.(910-912)cGc>cTc	p.R304L	AC002310.7_ENST00000492040.1_RNA|AC002310.7_ENST00000486926.1_RNA|ZNF785_ENST00000470110.1_Missense_Mutation_p.R289L	NM_152458.6	NP_689671.2	A8K8V0	ZN785_HUMAN	zinc finger protein 785	304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	9						GGTGTGTATGCGCCTGTGGAT	0.647000													3	47					0.000602214	0.000619927	1	1	0
TEX15	56154	broad.mit.edu	37	8	30701810	30701810	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr8:30701810G>A	ENST00000256246.2	-	1	4798	c.4724C>T	c.(4723-4725)aCg>aTg	p.T1575M		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1575										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TAAAATAGGCGTATGATTAAC	0.388000													9	104					0	0	1	0	0
MESP1	55897	broad.mit.edu	37	15	90293435	90293435	+	Silent	SNP	A	A	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr15:90293435A>C	ENST00000300057.4	-	2	825	c.747T>G	c.(745-747)gcT>gcG	p.A249A	MESP1_ENST00000559894.1_5'UTR	NM_018670.3	NP_061140.1	Q9BRJ9	MESP1_HUMAN	mesoderm posterior 1 homolog (mouse)	249					cardiac atrium formation|cardiac cell fate determination|cardiac vascular smooth muscle cell differentiation|cardiac ventricle formation|cardioblast anterior-lateral migration|cardioblast migration to the midline involved in heart field formation|endothelial cell differentiation|gastrulation|growth involved in heart morphogenesis|heart looping|lateral mesoderm development|negative regulation of endodermal cell fate specification|negative regulation of mesodermal cell fate specification|negative regulation of transcription, DNA-dependent|neurogenesis|Notch signaling pathway|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|positive regulation of hepatocyte differentiation|positive regulation of Notch signaling pathway|positive regulation of striated muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|secondary heart field specification|sinoatrial node cell differentiation|sinus venosus morphogenesis		sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(1)|kidney(1)	2	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			TCTCCAACAGAGCCAGCACGT	0.647000													11	73					0	0	1	0	0
EIF3M	10480	broad.mit.edu	37	11	32610273	32610273	+	Silent	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr11:32610273G>A	ENST00000531120.1	+	3	372	c.309G>A	c.(307-309)ctG>ctA	p.L103L	EIF3M_ENST00000524896.1_Intron	NM_006360.4	NP_006351.2	Q7L2H7	EIF3M_HUMAN	eukaryotic translation initiation factor 3, subunit M	103						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16	Breast(20;0.109)					CTCTGAGACTGCAGTTGTAAG	0.408000													4	122					0	0	1	0	0
ANKDD1A	348094	broad.mit.edu	37	15	65234714	65234714	+	Missense_Mutation	SNP	G	G	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr15:65234714G>T	ENST00000380230.3	+	10	947	c.918G>T	c.(916-918)ttG>ttT	p.L306F	ANKDD1A_ENST00000357698.3_Missense_Mutation_p.L306F|ANKDD1A_ENST00000395720.1_Missense_Mutation_p.L306F|ANKDD1A_ENST00000395723.1_Missense_Mutation_p.L215F	NM_182703.3	NP_874362.3	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	306					signal transduction					NS(1)|endometrium(1)|large_intestine(10)|liver(2)|lung(4)|ovary(1)|prostate(2)	21						TCCCTGCCTTGGTCCGGCTCC	0.602000													3	42					0.0215528	0.0218651	1	1	0
STT3A	3703	broad.mit.edu	37	11	125472775	125472775	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr11:125472775G>A	ENST00000392708.4	+	5	508	c.349G>A	c.(349-351)Gtg>Atg	p.V117M	STT3A_ENST00000529196.1_Missense_Mutation_p.V117M|STT3A_ENST00000531491.1_Missense_Mutation_p.V25M	NM_001278503.1|NM_001278504.1|NM_152713.3	NP_001265432.1|NP_001265433.1|NP_689926.1	P46977	STT3A_HUMAN	STT3A, subunit of the oligosaccharyltransferase complex (catalytic)	117					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity			NS(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(15)|skin(1)	33	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)		GAATGTCTGTGTGTTCCTGGC	0.488000													22	55					0	0	1	0	0
SCRN2	90507	broad.mit.edu	37	17	45916217	45916217	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr17:45916217G>A	ENST00000407215.3	-	5	793	c.712C>T	c.(712-714)Cgc>Tgc	p.R238C	SCRN2_ENST00000584123.1_Missense_Mutation_p.R246C|SCRN2_ENST00000290216.9_Missense_Mutation_p.R238C			Q96FV2	SCRN2_HUMAN	secernin 2	238					proteolysis		dipeptidase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	14						GCCTCCATGCGCACAGGCTGC	0.672000													5	136					0	0	1	0	0
QRICH1	54870	broad.mit.edu	37	3	49094329	49094329	+	Missense_Mutation	SNP	T	T	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr3:49094329T>G	ENST00000395443.2	-	3	1776	c.1304A>C	c.(1303-1305)cAg>cCg	p.Q435P	QRICH1_ENST00000424300.1_Missense_Mutation_p.Q435P|QRICH1_ENST00000479449.1_5'UTR|QRICH1_ENST00000357496.2_Missense_Mutation_p.Q435P	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	435	Gln-rich.									breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		ctgctgctgctgtggtggtgg	0.562000													3	66					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47296303	47296303	+	Silent	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr11:47296303G>A	ENST00000342922.4	+	3	609	c.252G>A	c.(250-252)aaG>aaA	p.K84K	MADD_ENST00000407859.3_Silent_p.K84K|MADD_ENST00000311027.5_Silent_p.K84K|MADD_ENST00000406482.1_Silent_p.K84K|MADD_ENST00000402799.1_Silent_p.K84K|MADD_ENST00000395344.3_Silent_p.K84K|MADD_ENST00000402192.2_Silent_p.K84K|MADD_ENST00000349238.3_Silent_p.K84K|MADD_ENST00000395336.3_Silent_p.K84K	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	84	UDENN.				activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		TCACTGACAAGGACACTGGAG	0.567000													3	135					0	0	1	0	0
OR11H4	390442	broad.mit.edu	37	14	20711208	20711208	+	Silent	SNP	C	C	T	rs150420661		TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr14:20711208C>T	ENST00000315409.2	+	1	311	c.258C>T	c.(256-258)tcC>tcT	p.S86S		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	86					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		ATGTGTCCTCCACTATTCCTA	0.453000													5	166					0	0	1	0	0
OR13C9	286362	broad.mit.edu	37	9	107379676	107379676	+	Silent	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr9:107379676T>C	ENST00000259362.1	-	1	809	c.810A>G	c.(808-810)tcA>tcG	p.S270S		NM_001001956.1	NP_001001956.1	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C, member 9	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(9)|prostate(1)|skin(4)	22						CCAAGTCATCTGAATTAAGTG	0.403000													4	86					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G|EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													5	88					0	0	1	0	0
FGF5	2250	broad.mit.edu	37	4	81207627	81207627	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr4:81207627G>A	ENST00000312465.7	+	3	834	c.608G>A	c.(607-609)aGc>aAc	p.S203N	FGF5_ENST00000503413.1_3'UTR|FGF5_ENST00000456523.3_3'UTR	NM_004464.3	NP_004455.2	P12034	FGF5_HUMAN	fibroblast growth factor 5	203					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22						CGAGGGTGCAGCCCCCGGGTT	0.473000													3	91					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	24105528	24105528	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr16:24105528T>C	ENST00000303531.7	+	7	883	c.731T>C	c.(730-732)aTt>aCt	p.I244T	PRKCB_ENST00000321728.7_Missense_Mutation_p.I244T|PRKCB_ENST00000482000.1_3'UTR	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	244	C2.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	TCAGTAGAGATTTGGGATTGG	0.418000													17	52					0	0	1	0	0
LINC00264	0	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													5	42					0	0	1	0	0
CLGN	1047	broad.mit.edu	37	4	141317054	141317054	+	Silent	SNP	A	A	G	rs145850842	by1000genomes	TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr4:141317054A>G	ENST00000325617.5	-	10	1508	c.1068T>C	c.(1066-1068)ggT>ggC	p.G356G	CLGN_ENST00000537281.1_Silent_p.G356G|CLGN_ENST00000414773.1_Silent_p.G356G	NM_004362.2	NP_004353.1	O14967	CLGN_HUMAN	calmegin	356					protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(5)|ovary(2)|prostate(3)|skin(4)|urinary_tract(1)	25	all_hematologic(180;0.162)					GTTTCCACTCACCACACCCAA	0.433000													3	63					0	0	1	0	0
OR10J1	26476	broad.mit.edu	37	1	159410187	159410187	+	Missense_Mutation	SNP	T	T	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr1:159410187T>G	ENST00000423932.3	+	1	676	c.639T>G	c.(637-639)agT>agG	p.S213R	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	213					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					TGATTATCAGTGTGCTGGTGC	0.458000													20	106					0	0	1	0	0
EXOC8	149371	broad.mit.edu	37	1	231471575	231471575	+	Silent	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr1:231471575C>T	ENST00000366645.1	-	1	2023	c.1905G>A	c.(1903-1905)ctG>ctA	p.L635L	EXOC8_ENST00000360394.2_Silent_p.L639L			Q8IYI6	EXOC8_HUMAN	exocyst complex component 8	639					exocytosis|protein transport	growth cone|nucleus	protein binding			cervix(2)|endometrium(1)|large_intestine(2)|liver(1)|lung(5)|prostate(1)|skin(1)|stomach(1)	14	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				GTACCATGTGCAGCTCTGGGA	0.478000													13	77					0	0	1	0	0
MTMR4	9110	broad.mit.edu	37	17	56585536	56585536	+	Silent	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr17:56585536G>A	ENST00000323456.5	-	8	775	c.651C>T	c.(649-651)ccC>ccT	p.P217P	MTMR4_ENST00000579925.1_Silent_p.P217P	NM_004687.4	NP_004678.3	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	217	Myotubularin phosphatase.					cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			breast(10)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|skin(5)	36	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ACACAACCACGGGAATCCGCT	0.522000													33	82					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414280	20414280	+	Silent	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr9:20414280G>A	ENST00000380338.4	-	5	850	c.564C>T	c.(562-564)agC>agT	p.S188S	MLLT3_ENST00000429426.2_Silent_p.S185S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	188	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S188S(1)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TGGTActactgctgctgctgc	0.502000			T	MLL	ALL								5	71					0	0	1	0	0
NNT	23530	broad.mit.edu	37	5	43700278	43700278	+	Silent	SNP	T	T	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr5:43700278T>G	ENST00000264663.5	+	20	3155	c.2934T>G	c.(2932-2934)gcT>gcG	p.A978A	NNT_ENST00000344920.4_Silent_p.A978A|NNT_ENST00000512996.2_Silent_p.A847A	NM_012343.3	NP_036475.3	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	978					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(7)|large_intestine(6)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(6;2.58e-06)				NADH(DB00157)	TGCTGCTGGCTGAGGCTGGTG	0.453000													26	85					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51774158	51774158	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr6:51774158T>C	ENST00000371117.3	-	40	6880	c.6605A>G	c.(6604-6606)aAg>aGg	p.K2202R	PKHD1_ENST00000340994.4_Missense_Mutation_p.K2202R	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	2202					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CTGCACTCCCTTCAACTGGAC	0.532000													3	185					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282808	152282808	+	Silent	SNP	A	A	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr1:152282808A>G	ENST00000368799.1	-	3	4589	c.4554T>C	c.(4552-4554)caT>caC	p.H1518H	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1518	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGGCTGTGATGGTACCCTG	0.562000									Ichthyosis				62	383					0	0	1	0	0
SPZ1	84654	broad.mit.edu	37	5	79616605	79616605	+	Missense_Mutation	SNP	C	C	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr5:79616605C>G	ENST00000296739.4	+	1	816	c.571C>G	c.(571-573)Cag>Gag	p.Q191E		NM_032567.3	NP_115956.3	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			endometrium(2)|kidney(5)|large_intestine(4)|lung(12)|ovary(1)|skin(2)	26		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		AAAGAAACAGCAGATGATAAT	0.353000													3	66					0	0	1	0	0
HEATR1	55127	broad.mit.edu	37	1	236749185	236749185	+	Missense_Mutation	SNP	G	G	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr1:236749185G>T	ENST00000366582.3	-	16	2098	c.1984C>A	c.(1984-1986)Cag>Aag	p.Q662K	HEATR1_ENST00000366581.2_Missense_Mutation_p.Q662K	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	662					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ATCATCTTCTGATTTGCTACA	0.363000													3	43					1	1	1	1	0
ACTC1	70	broad.mit.edu	37	15	35085746	35085746	+	Missense_Mutation	SNP	T	T	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr15:35085746T>G	ENST00000290378.4	-	3	809	c.154A>C	c.(154-156)Aag>Cag	p.K52Q	RP11-814P5.1_ENST00000503496.1_RNA	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	52					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		TAGGAGTCCTTCTGACCCATA	0.453000													5	27					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37617884	37617884	+	Silent	SNP	C	C	T	rs112487012		TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr21:37617884C>T	ENST00000399151.3	+	19	3691	c.3606C>T	c.(3604-3606)ctC>ctT	p.L1202L		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	1202					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						ACTTGGAGCTCCAGGCCCTCA	0.622000													4	35					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45127107	45127107	+	RNA	SNP	C	C	G	rs147409399	by1000genomes	TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr17:45127107C>G	ENST00000575173.1	-	0	418																											CCTTCGTTCACCCAAGAGCAT	0.592000													4	92					0	0	1	0	0
DENND5B	160518	broad.mit.edu	37	12	31586051	31586051	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr12:31586051G>A	ENST00000354285.4	-	9	2389	c.2210C>T	c.(2209-2211)gCg>gTg	p.A737V	DENND5B_ENST00000389082.5_Intron|DENND5B_ENST00000536562.1_Intron|DENND5B_ENST00000306833.6_Intron			Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	0						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						AGTTCATGGCGCTTGCTGTGA	0.433000													3	77					0	0	1	0	0
CPN1	1369	broad.mit.edu	37	10	101835675	101835675	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr10:101835675G>A	ENST00000370418.3	-	2	664	c.413C>T	c.(412-414)gCt>gTt	p.A138V		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	138	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		TACCTGGGCAGCAGCCACCTC	0.567000													3	48					0	0	1	0	0
DPY19L2	283417	broad.mit.edu	37	12	64041106	64041106	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr12:64041106T>C	ENST00000324472.4	-	5	811	c.628A>G	c.(628-630)Atg>Gtg	p.M210V	RP11-415I12.3_ENST00000509615.2_RNA	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	210					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		AATAAATTCATTATTCCCATG	0.318000													4	110					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025366	207025366	+	Silent	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr2:207025366G>A	ENST00000392222.2	+	2	510	c.135G>A	c.(133-135)ccG>ccA	p.P45P	EEF1B2_ENST00000392221.1_Silent_p.P45P|EEF1B2_ENST00000236957.5_Silent_p.P45P	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	45	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.P45P(5)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CCAGCCCACCGCCTGCCGACT	0.448000													5	93					0	0	1	0	0
FSCN3	29999	broad.mit.edu	37	7	127235557	127235557	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr7:127235557G>A	ENST00000265825.5	+	2	560	c.341G>A	c.(340-342)cGt>cAt	p.R114H	FSCN3_ENST00000420086.2_5'UTR	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	114						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging	p.R114H(1)		endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						ATCTCTGGTCGTTATTTGGAG	0.567000													3	57					0	0	1	0	0
CLEC1B	51266	broad.mit.edu	37	12	10147815	10147815	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr12:10147815G>A	ENST00000428126.2	-	6	639	c.370C>T	c.(370-372)Cgt>Tgt	p.R124C	CLEC1B_ENST00000298527.6_Missense_Mutation_p.R157C|CLEC1B_ENST00000348658.4_Missense_Mutation_p.R124C			Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B	157	C-type lectin.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity	p.R157C(1)|p.?(1)		NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(12)|stomach(1)|urinary_tract(1)	19						CCGACCCAACGAATTAAATGA	0.418000													51	267					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122774732	122774732	+	Silent	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr11:122774732G>A	ENST00000227349.2	+	3	741	c.444G>A	c.(442-444)ccG>ccA	p.P148P	C11orf63_ENST00000307257.6_Silent_p.P148P|C11orf63_ENST00000531316.1_Silent_p.P148P	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	148										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		AAGCGTTGCCGGAGTCCACGG	0.532000													3	118					0	0	1	0	0
ANKRD32	84250	broad.mit.edu	37	5	94022425	94022425	+	Splice_Site	SNP	T	T	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr5:94022425T>G	ENST00000265140.5	+	16	2540		c.e16+2			NM_032290.3	NP_115666.2	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32											NS(1)|breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|skin(1)	13		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		CAGAAAATGGTAAGTACCTCT	0.363000													14	67					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167277926	167277926	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr3:167277926C>T	ENST00000308378.3	-	5	882	c.577G>A	c.(577-579)Gca>Aca	p.A193T	WDR49_ENST00000453925.2_Missense_Mutation_p.A246T|WDR49_ENST00000476376.1_Missense_Mutation_p.A18T|WDR49_ENST00000479765.1_Intron	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	193										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						CTGATTTCTGCGTTGCCGTGG	0.453000													18	96					0	0	1	0	0
CSRNP3	80034	broad.mit.edu	37	2	166514412	166514412	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr2:166514412G>A	ENST00000314499.7	+	5	666	c.290G>A	c.(289-291)cGc>cAc	p.R97H	CSRNP3_ENST00000342316.4_Missense_Mutation_p.R97H|CSRNP3_ENST00000409420.1_Missense_Mutation_p.R129H	NM_001172173.1	NP_001165644.1	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	97					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.R97H(1)		breast(2)|cervix(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(3)|skin(2)	33						ATGTCCAGCCGCCATAACAGC	0.547000													3	46					0	0	1	0	0
HIST1H4B	8366	broad.mit.edu	37	6	26027359	26027359	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr6:26027359C>T	ENST00000377364.3	-	1	121	c.122G>A	c.(121-123)cGt>cAt	p.R41H		NM_003544.2	NP_003535.1	P62805	H4_HUMAN	histone cluster 1, H4b	41					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			large_intestine(4)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	13						AACCCCACCACGCCTAGCAAG	0.552000													4	62					0	0	1	0	0
ZNF780A	284323	broad.mit.edu	37	19	40580552	40580552	+	Missense_Mutation	SNP	T	T	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr19:40580552T>G	ENST00000450241.2	-	6	2006	c.1695A>C	c.(1693-1695)caA>caC	p.Q565H	ZNF780A_ENST00000455521.1_Missense_Mutation_p.Q600H|ZNF780A_ENST00000595687.2_Missense_Mutation_p.Q599H|ZNF780A_ENST00000340963.5_Missense_Mutation_p.Q599H|AC005614.5_ENST00000595508.1_RNA|ZNF780A_ENST00000414720.2_Intron|ZNF780A_ENST00000594395.1_Missense_Mutation_p.Q600H			O75290	Z780A_HUMAN	zinc finger protein 780A	599					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|upper_aerodigestive_tract(3)|urinary_tract(1)	31	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					GTCGAATAAGTTGCATATGAA	0.403000													3	148					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38810577	38810577	+	Missense_Mutation	SNP	A	A	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr6:38810577A>T	ENST00000359357.3	+	33	4346	c.4092A>T	c.(4090-4092)agA>agT	p.R1364S	DNAH8_ENST00000449981.2_Missense_Mutation_p.R1581S|DNAH8_ENST00000441566.1_Missense_Mutation_p.R1364S					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ACTGGGATAGAATCTCCGAGT	0.383000													24	99					0	0	1	0	0
ABCE1	6059	broad.mit.edu	37	4	146032204	146032204	+	Missense_Mutation	SNP	A	A	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr4:146032204A>C	ENST00000296577.4	+	8	1213	c.698A>C	c.(697-699)cAg>cCg	p.Q233P	ABCE1_ENST00000502803.1_Intron|OTUD4_ENST00000455611.2_5'UTR	NM_001040876.1|NM_002940.2	NP_001035809.1|NP_002931.2	P61221	ABCE1_HUMAN	ATP-binding cassette, sub-family E (OABP), member 1	233	ABC transporter 1.				interspecies interaction between organisms|response to virus|RNA catabolic process	mitochondrion	ATP binding|ATPase activity|electron carrier activity|iron-sulfur cluster binding|ribonuclease inhibitor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|lung(5)|prostate(2)|skin(3)	18	all_hematologic(180;0.151)					GTTTGCATACAGAAAGCTGAT	0.363000													6	69					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44071948	44071948	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr1:44071948G>A	ENST00000359947.4	+	20	3861	c.3521G>A	c.(3520-3522)cGg>cAg	p.R1174Q	PTPRF_ENST00000372413.3_Missense_Mutation_p.R1165Q|PTPRF_ENST00000372414.3_Missense_Mutation_p.R1174Q|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000422171.2_Missense_Mutation_p.R522Q|PTPRF_ENST00000438120.1_Missense_Mutation_p.R1165Q	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1174					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GAGGAGCAGCGGCGGCGGCGG	0.632000													4	92					0	0	1	0	0
HTR2C	3358	broad.mit.edu	37	X	113965800	113965800	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chrX:113965800C>T	ENST00000276198.1	+	4	861	c.133C>T	c.(133-135)Cgc>Tgc	p.R45C	HTR2C_ENST00000371951.1_Missense_Mutation_p.R45C|HTR2C_ENST00000371950.3_Missense_Mutation_p.R45C	NM_000868.2	NP_000859.1	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	45					cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	CGATGGTGGACGCTTCAAATT	0.443000													25	75					0	0	1	0	0
ELAVL2	1993	broad.mit.edu	37	9	23701423	23701423	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr9:23701423T>C	ENST00000397312.2	-	5	941	c.667A>G	c.(667-669)Aac>Gac	p.N223D	ELAVL2_ENST00000223951.6_Missense_Mutation_p.N223D|ELAVL2_ENST00000380117.1_Missense_Mutation_p.N223D|ELAVL2_ENST00000380110.4_Missense_Mutation_p.N252D|ELAVL2_ENST00000544538.1_Missense_Mutation_p.N223D	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	223					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TACCTTCTGTTTGGAGACTGG	0.488000													32	224					0	0	1	0	0
GPR4	2828	broad.mit.edu	37	19	46095073	46095073	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr19:46095073G>A	ENST00000323040.4	-	2	996	c.52C>T	c.(52-54)Ctc>Ttc	p.L18F	OPA3_ENST00000544371.1_Intron	NM_005282.2	NP_005273.1	P46093	GPR4_HUMAN	G protein-coupled receptor 4	18						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		GGCGGAAAGAGGTGGTCCACG	0.672000													10	59					0	0	1	0	0
PHTF1	10745	broad.mit.edu	37	1	114256026	114256026	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr1:114256026T>C	ENST00000369604.1	-	8	1141	c.658A>G	c.(658-660)Act>Gct	p.T220A	PHTF1_ENST00000447664.2_Intron|PHTF1_ENST00000369598.1_Missense_Mutation_p.T175A|PHTF1_ENST00000369600.1_Missense_Mutation_p.T167A|PHTF1_ENST00000369596.2_Missense_Mutation_p.T167A|PHTF1_ENST00000357783.2_Missense_Mutation_p.T220A|PHTF1_ENST00000393357.2_Missense_Mutation_p.T220A|PHTF1_ENST00000474926.1_5'UTR			Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1	220						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCAGTTTCAGTCCCTTTGTTA	0.318000													3	24					0	0	1	0	0
ZNF658	26149	broad.mit.edu	37	9	40773282	40773282	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr9:40773282T>C	ENST00000602553.1	-	5	2287	c.1993A>G	c.(1993-1995)Aga>Gga	p.R665G	ZNF658_ENST00000441795.1_Intron|ZNF658_ENST00000377626.3_Missense_Mutation_p.R665G			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	665					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GTGAAAGATCTCCCACATTCA	0.403000													3	156					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887686	12887686	+	Silent	SNP	T	T	C	rs59802947	by1000genomes	TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr1:12887686T>C	ENST00000535591.1	-	3	366	c.171A>G	c.(169-171)agA>agG	p.R57R		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	57								p.R57R(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GAAGTTTCCATCTCCTGTGGG	0.468000													3	219					0	0	1	0	0
EHHADH	1962	broad.mit.edu	37	3	184936017	184936017	+	Missense_Mutation	SNP	A	A	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr3:184936017A>C	ENST00000231887.3	-	5	550	c.475T>G	c.(475-477)Tta>Gta	p.L159V	EHHADH_ENST00000475987.1_5'UTR|EHHADH_ENST00000456310.1_Missense_Mutation_p.L63V	NM_001166415.1|NM_001966.3	NP_001159887.1|NP_001957.2	Q08426	ECHP_HUMAN	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	159	Enoyl-CoA hydratase / isomerase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(2)|skin(3)	24	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	TCATCTGCTAAAATACGTCTT	0.378000													29	104					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52883592	52883592	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr4:52883592G>A	ENST00000343457.3	-	1	194	c.188C>T	c.(187-189)gCc>gTc	p.A63V		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	63						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						ATCCACAGTGGCTGCTGTCTG	0.353000													5	42					0	0	1	0	0
CYP2W1	54905	broad.mit.edu	37	7	1024635	1024635	+	Silent	SNP	G	G	A			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr7:1024635G>A	ENST00000340150.6	+	3	241	c.219G>A	c.(217-219)acG>acA	p.T73T	CYP2W1_ENST00000308919.7_Silent_p.T129T			Q8TAV3	CP2W1_HUMAN	cytochrome P450, family 2, subfamily W, polypeptide 1	129					xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		GCCAGTTCACGGTGCGTGCCC	0.652000													9	60					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71346978	71346978	+	Missense_Mutation	SNP	T	T	C			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr4:71346978T>C	ENST00000413702.1	+	4	805	c.517T>C	c.(517-519)Tct>Cct	p.S173P	MUC7_ENST00000456088.1_Missense_Mutation_p.S173P|MUC7_ENST00000304887.5_Missense_Mutation_p.S173P|MUC7_ENST00000514512.1_3'UTR	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	173	Thr-rich.					extracellular region	protein binding	p.S173P(3)		central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			ACCCACACCTTCTGCAACTAC	0.522000													3	145					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128351136	128351136	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr2:128351136C>T	ENST00000389524.4	+	18	2214	c.2161C>T	c.(2161-2163)Cgc>Tgc	p.R721C	MYO7B_ENST00000409816.2_Missense_Mutation_p.R721C|MYO7B_ENST00000428314.1_Missense_Mutation_p.R721C			Q6PIF6	MYO7B_HUMAN	myosin VIIB	721	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		AGGCAAGCTCCGCCAGATGAC	0.612000													3	115					0	0	1	0	0
ZBTB8A	653121	broad.mit.edu	37	1	33065979	33065981	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr1:33065979_33065981delGAA	ENST00000373510.4	+	5	1514_1516	c.1285_1287delGAA	c.(1285-1287)del	p.E433del	ZBTB8OS_ENST00000341885.5_Intron|ZBTB8A_ENST00000316459.4_3'UTR|RP1-27O5.3_ENST00000480336.1_3'UTR	NM_001040441.1	NP_001035531.1	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	433	Poly-Glu.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(2)|large_intestine(2)|lung(2)|prostate(1)	7						TGATGATAGTGAAGAAGAAGAAG	0.414													9	101	---	---	---	---					
LMX1A	4009	broad.mit.edu	37	1	165177332	165177334	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr1:165177332_165177334delTGC	ENST00000342310.3	-	7	1165_1167	c.783_785delGCA	c.(781-786)caa>ca	p.QQ261del	LMX1A_ENST00000489443.2_5'UTR|LMX1A_ENST00000294816.2_In_Frame_Del_p.QQ261del|LMX1A_ENST00000367893.4_In_Frame_Del_p.QQ261del	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	261	Gln-rich.|Poly-Gln.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					CTGCTGATCTTGCTGCTGCTGCT	0.567													8	57	---	---	---	---					
FOXP2	93986	broad.mit.edu	37	7	114270016	114270018	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr7:114270016_114270018delCAG	ENST00000393500.3	+	11	1148_1150	c.328_330delCAG	c.(328-330)del	p.Q116del	FOXP2_ENST00000403559.4_In_Frame_Del_p.Q208del|FOXP2_ENST00000393494.2_In_Frame_Del_p.Q191del|FOXP2_ENST00000390668.3_In_Frame_Del_p.Q215del|FOXP2_ENST00000393498.2_In_Frame_Del_p.Q171del|FOXP2_ENST00000350908.4_In_Frame_Del_p.Q191del|FOXP2_ENST00000408937.3_In_Frame_Del_p.Q216del|FOXP2_ENST00000378237.3_In_Frame_Del_p.Q191del|FOXP2_ENST00000393491.3_In_Frame_Del_p.Q99del|FOXP2_ENST00000393489.3_In_Frame_Del_p.Q99del|FOXP2_ENST00000360232.4_In_Frame_Del_p.Q191del			O15409	FOXP2_HUMAN	forkhead box P2	191	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q210Q(2)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						gcagcagcaacagcagcagcagc	0.507													7	51	---	---	---	---					
RP11-180I4.2	0	broad.mit.edu	37	9	98468147	98468148	+	RNA	INS	-	-	CAC	rs117111638	by1000genomes	TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr9:98468147_98468148insCAC	ENST00000580326.1	+	0	189																											acaatcaccatcaccaccacca	0.574													3	4	---	---	---	---					
COL5A1	1289	broad.mit.edu	37	9	137534099	137534101	+	In_Frame_Del	DEL	GCT	GCT	-	rs13288533		TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr9:137534099_137534101delGCT	ENST00000371817.3	+	1	480_482	c.66_68delGCT	c.(64-69)ccg>cc	p.PL22del		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	22					axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		tgctgcccccgctgctgctgctg	0.828													2	4	---	---	---	---					
MAP3K9	4293	broad.mit.edu	37	14	71275774	71275776	+	In_Frame_Del	DEL	CCT	CCT	-	rs3832971		TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr14:71275774_71275776delCCT	ENST00000554752.2	-	1	112_114	c.113_115delAGG	c.(112-117)gcg>g	p.EA38del	MAP3K9_ENST00000381250.4_In_Frame_Del_p.EA38del|MAP3K9_ENST00000555993.2_In_Frame_Del_p.EA38del			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	38	Ala-rich.|Poly-Glu.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity	p.E38delE(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		GCCGCCGCCGcctcctcctcctc	0.773													4	4	---	---	---	---					
HERC2P3	0	broad.mit.edu	37	15	20710570	20710570	+	RNA	DEL	A	A	-			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr15:20710570delA	ENST00000428453.1	-	0	157																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						TACATACCCTAAAAAAAAGCC	0.368													2	4	---	---	---	---					
FRG1B	0	broad.mit.edu	37	20	29625899	29625900	+	Frame_Shift_Ins	INS	-	-	AT			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr20:29625899_29625900insAT	ENST00000278882.3	+	5	523_524	c.143_144insAT	c.(142-144)atafs	p.I48fs	FRG1B_ENST00000358464.4_Frame_Shift_Ins_p.I48fs|FRG1B_ENST00000439954.2_Frame_Shift_Ins_p.I53fs																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTATGGAAAATATCTTGGTA	0.342													7	104	---	---	---	---					
PMEPA1	56937	broad.mit.edu	37	20	56227348	56227349	+	Frame_Shift_Ins	INS	-	-	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-10A-01D-2115-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	fabbba2f-92b0-48b5-be7a-e4c9fc08b795	g.chr20:56227348_56227349insG	ENST00000341744.3	-	4	943_944	c.624_625insC	c.(622-627)ccgcagfs	p.Q209fs	PMEPA1_ENST00000265626.4_Frame_Shift_Ins_p.Q159fs|PMEPA1_ENST00000395814.1_Frame_Shift_Ins_p.Q159fs|PMEPA1_ENST00000395816.3_Frame_Shift_Ins_p.Q159fs|PMEPA1_ENST00000347215.4_Frame_Shift_Ins_p.Q174fs	NM_020182.4	NP_064567.2	Q969W9	PMEPA_HUMAN	prostate transmembrane protein, androgen induced 1	209					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						GAGTTACTGCTGGGGGGGCAGG	0.683													12	57	---	---	---	---					
ZBTB8A	653121	broad.mit.edu	37	1	33065979	33065981	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr1:33065979_33065981delGAA	ENST00000373510.4	+	5	1514_1516	c.1285_1287delGAA	c.(1285-1287)del	p.E433del	RP1-27O5.3_ENST00000480336.1_3'UTR|ZBTB8OS_ENST00000341885.5_Intron|ZBTB8A_ENST00000316459.4_3'UTR	NM_001040441.1	NP_001035531.1	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	433	Poly-Glu.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(2)|large_intestine(2)|lung(2)|prostate(1)	7						TGATGATAGTGAAGAAGAAGAAG	0.414													9	101	---	---	---	---					
PROM1	8842	broad.mit.edu	37	4	15995680	15995680	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr4:15995680delT	ENST00000505450.1	-	15	2282	c.1670delA	c.(1669-1671)atfs	p.N557fs	PROM1_ENST00000510224.1_Frame_Shift_Del_p.N566fs|PROM1_ENST00000508167.1_Frame_Shift_Del_p.N557fs|PROM1_ENST00000540805.1_Frame_Shift_Del_p.N566fs|PROM1_ENST00000543373.1_Frame_Shift_Del_p.N557fs|PROM1_ENST00000539194.1_Frame_Shift_Del_p.N566fs|PROM1_ENST00000447510.2_Frame_Shift_Del_p.N566fs	NM_001145848.1	NP_001139320.1	O43490	PROM1_HUMAN	prominin 1	566					camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|liver(1)|lung(11)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(2)	35						AGTGCCTCTATTTTTTTTGCA	0.428													7	99	---	---	---	---					
FOXP2	93986	broad.mit.edu	37	7	114270016	114270018	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr7:114270016_114270018delCAG	ENST00000393500.3	+	11	1148_1150	c.328_330delCAG	c.(328-330)del	p.Q116del	FOXP2_ENST00000360232.4_In_Frame_Del_p.Q191del|FOXP2_ENST00000390668.3_In_Frame_Del_p.Q215del|FOXP2_ENST00000393498.2_In_Frame_Del_p.Q171del|FOXP2_ENST00000393491.3_In_Frame_Del_p.Q99del|FOXP2_ENST00000403559.4_In_Frame_Del_p.Q208del|FOXP2_ENST00000393494.2_In_Frame_Del_p.Q191del|FOXP2_ENST00000408937.3_In_Frame_Del_p.Q216del|FOXP2_ENST00000393489.3_In_Frame_Del_p.Q99del|FOXP2_ENST00000350908.4_In_Frame_Del_p.Q191del|FOXP2_ENST00000378237.3_In_Frame_Del_p.Q191del			O15409	FOXP2_HUMAN	forkhead box P2	191	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q210Q(2)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						gcagcagcaacagcagcagcagc	0.507													7	51	---	---	---	---					
RP11-324H6.5	0	broad.mit.edu	37	10	51814320	51814320	+	RNA	DEL	A	A	-	rs11306955		TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr10:51814320delA	ENST00000456967.1	-	0	1657					NR_038275.1																						AACTCTATTGAGAAAAACCTG	0.358													4	4	---	---	---	---					
ULK4P3	0	broad.mit.edu	37	15	30406088	30406089	+	RNA	INS	-	-	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr15:30406088_30406089insT	ENST00000568486.1	+	0	402					NR_026859.1																						TGCCTCAAAAGTTTTTTTTTTT	0.297													3	5	---	---	---	---					
RP11-178C3.2	0	broad.mit.edu	37	17	58050857	58050857	+	RNA	DEL	G	G	-			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr17:58050857delG	ENST00000586209.1	+	0	158																											TTTTTTTTTTGGCAGTTTTTA	0.423													3	6	---	---	---	---					
OR7E24	26648	broad.mit.edu	37	19	9361740	9361741	+	Frame_Shift_Ins	INS	-	-	T			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr19:9361740_9361741insT	ENST00000456448.1	+	1	135_136	c.21_22insT	c.(19-24)ctttttfs	p.LF7fs		NM_001079935.1	NP_001073404.1	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E, member 24	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)	16						TTCCAATTCTCTTTTTTTTTTT	0.386													3	6	---	---	---	---					
PMEPA1	56937	broad.mit.edu	37	20	56227348	56227349	+	Frame_Shift_Ins	INS	-	-	G			TCGA-HC-7745-01A-11D-2114-08	TCGA-HC-7745-11A-01D-2114-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e51da70-984c-491f-a9eb-1bbb34f01a49	3cae220e-d1a9-454a-82c3-f381e1b08a26	g.chr20:56227348_56227349insG	ENST00000341744.3	-	4	943_944	c.624_625insC	c.(622-627)ccgcagfs	p.Q209fs	PMEPA1_ENST00000347215.4_Frame_Shift_Ins_p.Q174fs|PMEPA1_ENST00000395814.1_Frame_Shift_Ins_p.Q159fs|PMEPA1_ENST00000265626.4_Frame_Shift_Ins_p.Q159fs|PMEPA1_ENST00000395816.3_Frame_Shift_Ins_p.Q159fs	NM_020182.4	NP_064567.2	Q969W9	PMEPA_HUMAN	prostate transmembrane protein, androgen induced 1	209					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						GAGTTACTGCTGGGGGGGCAGG	0.683													12	57	---	---	---	---