Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MYH7	4625	broad.mit.edu	37	14	23887583	23887583	+	Silent	SNP	C	C	T	rs144465613	byFrequency	TCGA-J4-AATV-01A-11D-A41K-08	TCGA-J4-AATV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fbdfb5d-faed-48d4-a2e3-daea6ac7e9b1	93f8b7dd-abc6-4e05-b850-16523635aa29	g.chr14:23887583C>T	ENST00000355349.3	-	30	4167	c.4005G>A	c.(4003-4005)tcG>tcA	p.S1335S		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1335					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.S1335S(3)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATGCCGGGCCGACTGCAGTG	0.662000													4	37					0	0	1	0	0
TBC1D2	55357	broad.mit.edu	37	9	101014206	101014206	+	Silent	SNP	G	G	A	rs143910740		TCGA-J4-AATV-01A-11D-A41K-08	TCGA-J4-AATV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fbdfb5d-faed-48d4-a2e3-daea6ac7e9b1	93f8b7dd-abc6-4e05-b850-16523635aa29	g.chr9:101014206G>A	ENST00000375066.5	-	2	463	c.372C>T	c.(370-372)gcC>gcT	p.A124A	TBC1D2_ENST00000375064.1_Silent_p.A124A|TBC1D2_ENST00000342112.5_Intron	NM_018421.3	NP_060891.3	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	124	Interaction with CADH1.|PH.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		GCTTGGTGGCGGCCTGAGAAG	0.607000													3	57					0	0	1	0	0
EIF3J	8669	broad.mit.edu	37	15	44829572	44829572	+	Missense_Mutation	SNP	G	G	T			TCGA-J4-AATV-01A-11D-A41K-08	TCGA-J4-AATV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fbdfb5d-faed-48d4-a2e3-daea6ac7e9b1	93f8b7dd-abc6-4e05-b850-16523635aa29	g.chr15:44829572G>T	ENST00000261868.5	+	2	232	c.94G>T	c.(94-96)Ggc>Tgc	p.G32C	EIF3J_ENST00000424492.3_Missense_Mutation_p.G32C|EIF3J_ENST00000535391.1_Missense_Mutation_p.G32C	NM_003758.2	NP_003749.2	O75822	EIF3J_HUMAN	eukaryotic translation initiation factor 3, subunit J	32	Poly-Gly.|Sufficient for interaction with EIF3B.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			endometrium(1)|large_intestine(5)|liver(2)|skin(1)	9		all_cancers(109;2.81e-14)|all_epithelial(112;2.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;3.13e-20)|GBM - Glioblastoma multiforme(94;9.81e-07)|COAD - Colon adenocarcinoma(120;0.0754)|Colorectal(105;0.0758)		GGGGGGCGGCGGCACTGCCGG	0.721000													2	2					1	1	1	1	0
ATP11C	286410	broad.mit.edu	37	X	138856996	138856996	+	Missense_Mutation	SNP	A	A	G			TCGA-J4-AATV-01A-11D-A41K-08	TCGA-J4-AATV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fbdfb5d-faed-48d4-a2e3-daea6ac7e9b1	93f8b7dd-abc6-4e05-b850-16523635aa29	g.chrX:138856996A>G	ENST00000370557.1	-	19	3096	c.2069T>C	c.(2068-2070)cTt>cCt	p.L690P	ATP11C_ENST00000370543.1_Missense_Mutation_p.L693P|ATP11C_ENST00000361648.2_Missense_Mutation_p.L693P|ATP11C_ENST00000359686.2_Missense_Mutation_p.L693P|ATP11C_ENST00000460773.1_5'UTR|ATP11C_ENST00000327569.3_Missense_Mutation_p.L693P			Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C	693					ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(31)|ovary(5)|prostate(1)|skin(3)	75	Acute lymphoblastic leukemia(192;0.000127)					GGTCTGGAAAAGGCGGCAGGC	0.453000													3	74					0	0	1	0	0
ZNF518A	9849	broad.mit.edu	37	10	97918507	97918507	+	RNA	SNP	C	C	T			TCGA-J4-AATV-01A-11D-A41K-08	TCGA-J4-AATV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fbdfb5d-faed-48d4-a2e3-daea6ac7e9b1	93f8b7dd-abc6-4e05-b850-16523635aa29	g.chr10:97918507C>T	ENST00000534948.1	+	0	3285							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		TAAAGGCTTGCCACTTCATTG	0.383000													3	26					0	0	1	0	0
C1orf216	127703	broad.mit.edu	37	1	36181895	36181895	+	Nonsense_Mutation	SNP	C	C	A			TCGA-J4-AATV-01A-11D-A41K-08	TCGA-J4-AATV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fbdfb5d-faed-48d4-a2e3-daea6ac7e9b1	93f8b7dd-abc6-4e05-b850-16523635aa29	g.chr1:36181895C>A	ENST00000270815.4	-	2	798	c.28G>T	c.(28-30)Gag>Tag	p.E10*	C1orf216_ENST00000503824.1_5'UTR	NM_152374.1	NP_689587.1	Q8TAB5	CA216_HUMAN	chromosome 1 open reading frame 216	10										kidney(2)|lung(3)|skin(2)|urinary_tract(1)	8		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				TGGCCCCCCTCAGCTAGCCCT	0.572000											OREG0013357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	18					1	1	1	1	0
CAPN6	827	broad.mit.edu	37	X	110494483	110494483	+	Missense_Mutation	SNP	C	C	A			TCGA-J4-AATV-01A-11D-A41K-08	TCGA-J4-AATV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fbdfb5d-faed-48d4-a2e3-daea6ac7e9b1	93f8b7dd-abc6-4e05-b850-16523635aa29	g.chrX:110494483C>A	ENST00000324068.1	-	7	1092	c.925G>T	c.(925-927)Gat>Tat	p.D309Y	CAPN6_ENST00000541758.1_Missense_Mutation_p.D54Y	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6	309	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						TTCTTGCGATCTGATGCAGTC	0.398000													3	32					0.115264	0.129672	1	1	0
GTF3C1	2975	broad.mit.edu	37	16	27472773	27472773	+	Silent	SNP	G	G	A			TCGA-J4-AATV-01A-11D-A41K-08	TCGA-J4-AATV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fbdfb5d-faed-48d4-a2e3-daea6ac7e9b1	93f8b7dd-abc6-4e05-b850-16523635aa29	g.chr16:27472773G>A	ENST00000356183.4	-	37	6243	c.6228C>T	c.(6226-6228)gaC>gaT	p.D2076D	GTF3C1_ENST00000561623.1_Silent_p.D2051D	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	2076						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						TGGGGCTCTCGTCCAGGCTGG	0.617000													5	87					0	0	1	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185903	127185903	+	Missense_Mutation	SNP	G	G	A			TCGA-J4-AATV-01A-11D-A41K-08	TCGA-J4-AATV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fbdfb5d-faed-48d4-a2e3-daea6ac7e9b1	93f8b7dd-abc6-4e05-b850-16523635aa29	g.chrX:127185903G>A	ENST00000371124.3	-	1	479	c.283C>T	c.(283-285)Cgg>Tgg	p.R95W		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	95						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						CCAAGCTCCCGCTCAAAGAGA	0.473000													4	166					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23887535	23887535	+	Silent	SNP	C	C	T			TCGA-J4-AATV-01A-11D-A41K-08	TCGA-J4-AATV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fbdfb5d-faed-48d4-a2e3-daea6ac7e9b1	93f8b7dd-abc6-4e05-b850-16523635aa29	g.chr14:23887535C>T	ENST00000355349.3	-	30	4215	c.4053G>A	c.(4051-4053)acG>acA	p.T1351T		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1351					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.T1351T(1)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CCTTGGCCTCCGTCTCCTCCT	0.672000													3	69					0	0	1	0	0
GGT3P	0	broad.mit.edu	37	22	18769145	18769145	+	RNA	SNP	G	G	A			TCGA-J4-AATV-01A-11D-A41K-08	TCGA-J4-AATV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fbdfb5d-faed-48d4-a2e3-daea6ac7e9b1	93f8b7dd-abc6-4e05-b850-16523635aa29	g.chr22:18769145G>A	ENST00000412448.1	-	0	1141																											TGAGGCTGCCGTTGTAGAAGG	0.612000													4	23					0	0	1	0	0
IKZF3	22806	broad.mit.edu	37	17	37985743	37985743	+	Splice_Site	SNP	T	T	G			TCGA-J4-AATV-01A-11D-A41K-08	TCGA-J4-AATV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fbdfb5d-faed-48d4-a2e3-daea6ac7e9b1	93f8b7dd-abc6-4e05-b850-16523635aa29	g.chr17:37985743T>G	ENST00000346872.3	-	3	123		c.e3-2		IKZF3_ENST00000377958.2_Splice_Site|IKZF3_ENST00000351680.3_Splice_Site|IKZF3_ENST00000350532.3_Splice_Site|IKZF3_ENST00000346243.3_Splice_Site|IKZF3_ENST00000394189.2_Splice_Site|IKZF3_ENST00000467757.1_Splice_Site|IKZF3_ENST00000377944.3_Splice_Site|IKZF3_ENST00000377945.3_Splice_Site|IKZF3_ENST00000439016.2_Splice_Site|IKZF3_ENST00000535189.1_Intron|IKZF3_ENST00000439167.2_Intron|IKZF3_ENST00000377952.2_Splice_Site	NM_012481.4	NP_036613.2	Q9UKT9	IKZF3_HUMAN	IKAROS family zinc finger 3 (Aiolos)						B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(6)|large_intestine(4)|liver(1)|lung(13)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CTGCACTTTCTAAAAGATAAA	0.348000													4	59					0	0	1	0	0
ZNF106	64397	broad.mit.edu	37	15	42740292	42740292	+	Missense_Mutation	SNP	C	C	A			TCGA-J4-AATV-01A-11D-A41K-08	TCGA-J4-AATV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fbdfb5d-faed-48d4-a2e3-daea6ac7e9b1	93f8b7dd-abc6-4e05-b850-16523635aa29	g.chr15:42740292C>A	ENST00000263805.4	-	3	3370	c.3044G>T	c.(3043-3045)aGa>aTa	p.R1015I	ZNF106_ENST00000565380.1_Missense_Mutation_p.R243I|ZNF106_ENST00000565611.1_Missense_Mutation_p.R200I	NM_022473.1	NP_071918.1			zinc finger protein 106																		TCGTTTCTTTCTAATACTTTG	0.448000													4	124					0.014758	0.0177096	1	1	0
TRIM48	79097	broad.mit.edu	37	11	55035844	55035844	+	Missense_Mutation	SNP	T	T	C			TCGA-J4-AATV-01A-11D-A41K-08	TCGA-J4-AATV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fbdfb5d-faed-48d4-a2e3-daea6ac7e9b1	93f8b7dd-abc6-4e05-b850-16523635aa29	g.chr11:55035844T>C	ENST00000417545.2	+	4	660	c.574T>C	c.(574-576)Tac>Cac	p.Y192H		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	176						intracellular	zinc ion binding	p.Y192H(11)|p.Y176H(11)		endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						AGACATATTATACAGGTGAGT	0.338000													4	70					0	0	1	0	0
NADK	65220	broad.mit.edu	37	1	1688587	1688588	+	Frame_Shift_Ins	INS	-	-	C			TCGA-J4-AATV-01A-11D-A41K-08	TCGA-J4-AATV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fbdfb5d-faed-48d4-a2e3-daea6ac7e9b1	93f8b7dd-abc6-4e05-b850-16523635aa29	g.chr1:1688587_1688588insC	ENST00000344463.4	-	6	958_959	c.737_738insG	c.(736-738)ggcfs	p.G246fs	NADK_ENST00000342348.5_Intron|NADK_ENST00000378625.1_Frame_Shift_Ins_p.G246fs|NADK_ENST00000492768.1_Intron|NADK_ENST00000341991.3_Intron|NADK_ENST00000341426.5_Intron			O95544	NADK_HUMAN	NAD kinase	131					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding			NS(1)|autonomic_ganglia(1)|endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)|stomach(1)|urinary_tract(1)	17	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		CTCCATGTGCACCCCAGGCCCC	0.634													2	4	---	---	---	---