Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SMARCAD1	56916	broad.mit.edu	37	4	95204449	95204449	+	Missense_Mutation	SNP	G	G	T			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr4:95204449G>T	ENST00000354268.4	+	22	2977	c.2904G>T	c.(2902-2904)caG>caT	p.Q968H	SMARCAD1_ENST00000457823.2_Missense_Mutation_p.Q970H|SMARCAD1_ENST00000509418.1_Missense_Mutation_p.Q538H			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	968	Helicase C-terminal.				chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		GAGTAGGCCAGACTAAGTAAG	0.333000													3	36					1.23904e-05	1.32164e-05	1	1	0
PACS2	23241	broad.mit.edu	37	14	105818770	105818770	+	Missense_Mutation	SNP	T	T	C			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr14:105818770T>C	ENST00000447393.1	+	3	438	c.263T>C	c.(262-264)gTg>gCg	p.V88A	PACS2_ENST00000458164.2_Missense_Mutation_p.V88A|PACS2_ENST00000430725.2_Missense_Mutation_p.V21A|PACS2_ENST00000325438.8_Missense_Mutation_p.V88A|PACS2_ENST00000547217.1_Intron	NM_015197.3	NP_056012.2	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	88					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				endometrium(2)|kidney(2)|lung(7)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	21		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		AGTGGACAAGTGGAGACAGAC	0.567000											OREG0022968	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	93					0	0	1	0	0
SNHG14	0	broad.mit.edu	37	15	25332934	25332934	+	RNA	SNP	G	G	T	rs112202902	by1000genomes	TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr15:25332934G>T	ENST00000546682.1	+	0	586				SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA	NR_003361.1																						AGACAGAGAAGGCCAACATCC	0.483000													71	153					1.50372e-20	1.71854e-20	1	1	0
PTCHD4	442213	broad.mit.edu	37	6	47846814	47846814	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr6:47846814C>T	ENST00000339488.4	-	3	1799	c.1766G>A	c.(1765-1767)cGa>cAa	p.R589Q		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	589						integral to membrane	hedgehog receptor activity										GATATCATTTCGAAAATGCTG	0.423000													9	29					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887308	12887308	+	Silent	SNP	C	C	T			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr1:12887308C>T	ENST00000535591.1	-	3	744	c.549G>A	c.(547-549)caG>caA	p.Q183Q		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	183								p.Q183H(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						ATGGGGTAAACTGTGTCAGGA	0.498000													9	324					0	0	1	0	0
NEK4	6787	broad.mit.edu	37	3	52786023	52786023	+	Missense_Mutation	SNP	G	G	C			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr3:52786023G>C	ENST00000233027.5	-	7	1495	c.1293C>G	c.(1291-1293)gaC>gaG	p.D431E	NEK4_ENST00000383721.4_Missense_Mutation_p.D431E|NEK4_ENST00000535191.1_Missense_Mutation_p.D342E	NM_001193533.1|NM_003157.4	NP_001180462.1|NP_003148.2	P51957	NEK4_HUMAN	NIMA-related kinase 4	431					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(10)	26				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		CAGTGACAATGTCAGAGGACC	0.468000													63	149					0	0	1	0	0
MIR100	0	broad.mit.edu	37	11	122023002	122023002	+	RNA	SNP	G	G	A			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr11:122023002G>A	ENST00000385259.1	-	0	14					NR_029515.1																						GGATCTACGGGTTTGTGGCAA	0.418000													12	49					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131191226	131191226	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr6:131191226C>T	ENST00000337057.3	-	15	2265	c.2084G>A	c.(2083-2085)cGg>cAg	p.R695Q	EPB41L2_ENST00000527411.1_Missense_Mutation_p.R625Q|EPB41L2_ENST00000530481.1_Missense_Mutation_p.R625Q|EPB41L2_ENST00000527659.1_Missense_Mutation_p.R625Q|EPB41L2_ENST00000530757.1_Intron|EPB41L2_ENST00000525271.1_Intron|EPB41L2_ENST00000445890.2_Intron|EPB41L2_ENST00000525193.1_Intron|EPB41L2_ENST00000392427.3_Intron|EPB41L2_ENST00000524581.1_Missense_Mutation_p.R73Q|EPB41L2_ENST00000529208.1_Missense_Mutation_p.R625Q|EPB41L2_ENST00000531410.1_Intron|EPB41L2_ENST00000368128.2_Missense_Mutation_p.R695Q|EPB41L2_ENST00000528282.1_Intron	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	695					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		AACCTCTGCCCGCTTCTTCTC	0.408000													8	41					0	0	1	0	0
SPANXN1	494118	broad.mit.edu	37	X	144337277	144337277	+	Silent	SNP	T	T	C			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chrX:144337277T>C	ENST00000370493.3	+	2	921	c.162T>C	c.(160-162)ttT>ttC	p.F54F		NM_001009614.2	NP_001009614.1	Q5VSR9	SPXN1_HUMAN	SPANX family, member N1	54										endometrium(2)|kidney(2)|lung(8)|prostate(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					TATTAGCGTTTTGCTACAGGA	0.433000													3	56					0	0	1	0	0
TMEM5	10329	broad.mit.edu	37	12	64174844	64174844	+	Missense_Mutation	SNP	A	A	G			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr12:64174844A>G	ENST00000261234.6	+	2	373	c.215A>G	c.(214-216)gAt>gGt	p.D72G	TMEM5_ENST00000537373.1_5'UTR|TMEM5_ENST00000537982.1_3'UTR|RP11-415I12.3_ENST00000509615.2_RNA	NM_014254.1	NP_055069.1	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	72						integral to plasma membrane				breast(1)|large_intestine(3)|liver(2)|lung(7)|prostate(1)|skin(1)	15		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		TGGGAAGGAGATGAAAAAAAT	0.348000													19	51					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96731943	96731943	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr10:96731943C>T	ENST00000260682.6	+	6	914	c.902C>T	c.(901-903)aCg>aTg	p.T301M		NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	301					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	GGGACAGAGACGACAAGCACA	0.418000													26	74					0	0	1	0	0
CHRNA1	1134	broad.mit.edu	37	2	175618303	175618303	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr2:175618303C>T	ENST00000348749.5	-	6	783	c.706G>A	c.(706-708)Gtc>Atc	p.V236I	AC018890.6_ENST00000442996.1_RNA|CHRNA1_ENST00000409323.1_Missense_Mutation_p.V236I|CHRNA1_ENST00000261007.5_Missense_Mutation_p.V261I|CHRNA1_ENST00000409219.1_Missense_Mutation_p.V236I|CHRNA1_ENST00000409542.1_Missense_Mutation_p.V154I	NM_000079.3	NP_000070.1	P02708	ACHA_HUMAN	cholinergic receptor, nicotinic, alpha 1 (muscle)	261					muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(3)|prostate(3)|skin(4)	37						ATGACGTTGACGATGAAGTAG	0.582000													16	69					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159162404	159162404	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr1:159162404C>T	ENST00000368125.4	+	3	423	c.266C>T	c.(265-267)aCg>aTg	p.T89M	CADM3_ENST00000368124.4_Missense_Mutation_p.T123M	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	89	Ig-like V-type.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity	p.T123M(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					GTTACCTCTACGCCCCACGAG	0.507000													16	43					0	0	1	0	0
CLCN5	1184	broad.mit.edu	37	X	49689925	49689925	+	Splice_Site	SNP	G	G	T			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chrX:49689925G>T	ENST00000376088.3	+	3	657		c.e3+1		CLCN5_ENST00000482218.1_Splice_Site|CLCN5_ENST00000376091.3_Splice_Site	NM_001127898.1|NM_001127899.1	NP_001121370.1|NP_001121371.1	P51795	CLCN5_HUMAN	chloride channel, voltage-sensitive 5						excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)	30	Ovarian(276;0.236)					ATGTGGCAGGGTAAGAAATTA	0.507000													19	25					1.64113e-05	1.69407e-05	1	1	0
COL5A1	1289	broad.mit.edu	37	9	137642401	137642401	+	Missense_Mutation	SNP	G	G	A	rs146716315		TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr9:137642401G>A	ENST00000371817.3	+	12	1922	c.1508G>A	c.(1507-1509)cGc>cAc	p.R503H		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	503	Interrupted collagenous region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCCCCTGGACGCCCAGGCCTT	0.662000													12	36					0	0	1	0	0
DZIP1L	199221	broad.mit.edu	37	3	137802957	137802957	+	Missense_Mutation	SNP	T	T	A			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr3:137802957T>A	ENST00000327532.2	-	8	1563	c.1201A>T	c.(1201-1203)Atg>Ttg	p.M401L	DZIP1L_ENST00000488595.1_Intron|DZIP1L_ENST00000469243.1_Missense_Mutation_p.M401L	NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	401						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						AGACCTACCATCTCCTCCTGG	0.567000													20	65					0	0	1	0	0
SUSD1	64420	broad.mit.edu	37	9	114820961	114820961	+	Missense_Mutation	SNP	T	T	C			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr9:114820961T>C	ENST00000374270.3	-	14	2028	c.1856A>G	c.(1855-1857)tAt>tGt	p.Y619C	SUSD1_ENST00000374263.3_Missense_Mutation_p.Y619C|SUSD1_ENST00000374264.2_Missense_Mutation_p.Y619C	NM_022486.3	NP_071931.2	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1	619						integral to membrane	calcium ion binding		SUSD1/ROD1(2)	central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28						TAACACCTGATATGAACTGGA	0.453000													8	50					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577102	7577102	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr17:7577102C>T	ENST00000420246.2	-	8	968	c.836G>A	c.(835-837)gGg>gAg	p.G279E	TP53_ENST00000445888.2_Missense_Mutation_p.G279E|TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Missense_Mutation_p.G279E|TP53_ENST00000269305.4_Missense_Mutation_p.G279E|TP53_ENST00000455263.2_Missense_Mutation_p.G279E	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	279	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		G -> E (in sporadic cancers; somatic mutation).|G -> R (in sporadic cancers; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).|G -> W (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G279E(32)|p.0?(8)|p.G279V(4)|p.?(2)|p.G279fs*65(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.G279_R280delGR(1)|p.F270_D281del12(1)|p.G279fs*59(1)|p.R280fs*62(1)|p.G279fs*26(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTCTCTCCCAGGACAGGC	0.547000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	7					0	0	1	0	0
EIF4E3	317649	broad.mit.edu	37	3	71745611	71745611	+	Splice_Site	SNP	C	C	T			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr3:71745611C>T	ENST00000448225.1	-	5	543	c.87_splice	c.e5+1	p.T29_splice	EIF4E3_ENST00000295612.3_Splice_Site_p.T29_splice|EIF4E3_ENST00000425534.2_Splice_Site_p.T135_splice|EIF4E3_ENST00000468147.1_Intron|EIF4E3_ENST00000389826.3_Splice_Site_p.T29_splice|EIF4E3_ENST00000421769.2_Splice_Site_p.T29_splice	NM_001134649.1	NP_001128121.1	Q8N5X7	IF4E3_HUMAN	eukaryotic translation initiation factor 4E family member 3	135					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity			large_intestine(1)|lung(3)	4		Prostate(10;0.0166)		BRCA - Breast invasive adenocarcinoma(55;2.56e-05)|Epithelial(33;2.9e-05)|Lung(16;9.28e-05)|LUSC - Lung squamous cell carcinoma(21;0.00227)		AGGAACCTACCGTGCTGTCCT	0.493000													14	47					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	40					0	0	1	0	0
VSIG10	54621	broad.mit.edu	37	12	118533490	118533490	+	Missense_Mutation	SNP	T	T	C			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr12:118533490T>C	ENST00000359236.5	-	2	485	c.209A>G	c.(208-210)aAc>aGc	p.N70S	VSIG10_ENST00000536905.1_5'UTR	NM_019086.5	NP_061959.2	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	70	Ig-like C2-type 1.					integral to membrane				endometrium(5)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|urinary_tract(1)	17						GAGGCTAGAGTTGGACGAGAG	0.572000													10	24					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129182397	129182397	+	Missense_Mutation	SNP	T	T	C			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr3:129182397T>C	ENST00000504021.1	+	4	297	c.203T>C	c.(202-204)aTt>aCt	p.I68T	IFT122_ENST00000296266.3_Intron|IFT122_ENST00000349441.2_Intron|IFT122_ENST00000431818.2_Intron|IFT122_ENST00000347300.2_Intron|IFT122_ENST00000507564.1_Intron|IFT122_ENST00000440957.2_Intron|IFT122_ENST00000348417.2_Intron			Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	99					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						TTATTGTGCATTGAAGGGTTG	0.388000													22	49					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9049442	9049442	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr19:9049442G>A	ENST00000397910.4	-	5	32392	c.32189C>T	c.(32188-32190)tCa>tTa	p.S10730L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10732	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGCACCAGGTGAGACAGTCAT	0.453000													58	157					0	0	1	0	0
ESR1	2099	broad.mit.edu	37	6	152420002	152420002	+	Silent	SNP	G	G	A	rs147982903		TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr6:152420002G>A	ENST00000440973.1	+	10	2059	c.1689G>A	c.(1687-1689)acG>acA	p.T563T	ESR1_ENST00000456483.2_Silent_p.T451T|ESR1_ENST00000338799.5_Silent_p.T563T|ESR1_ENST00000544394.1_Intron|ESR1_ENST00000443427.1_Silent_p.T563T|ESR1_ENST00000406599.1_Silent_p.T302T|ESR1_ENST00000206249.3_Silent_p.T563T	NM_001122742.1	NP_001116214.1	P03372	ESR1_HUMAN	estrogen receptor 1	563	Interaction with AKAP13.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(19)|ovary(1)|prostate(2)|skin(1)	49		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	TGGAGGAGACGGACCAAAGCC	0.607000													3	42					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61848065	61848065	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr10:61848065G>A	ENST00000280772.1	-	29	3571	c.3380C>T	c.(3379-3381)aCg>aTg	p.T1127M	ANK3_ENST00000373827.2_Missense_Mutation_p.T1121M|ANK3_ENST00000355288.2_Missense_Mutation_p.T261M|ANK3_ENST00000503366.1_Missense_Mutation_p.T1128M	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1127					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GAAATCTTTCGTGATAATCCT	0.433000													36	53					0	0	1	0	0
ADAM10	102	broad.mit.edu	37	15	58925526	58925526	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr15:58925526G>A	ENST00000260408.3	-	9	1488	c.1045C>T	c.(1045-1047)Ctc>Ttc	p.L349F	ADAM10_ENST00000396140.2_Missense_Mutation_p.L48F|ADAM10_ENST00000402627.1_Missense_Mutation_p.L48F|ADAM10_ENST00000561288.1_Intron	NM_001110.2	NP_001101.1	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10	349	Peptidase M12B.				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			breast(1)|endometrium(1)|kidney(5)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)	27				GBM - Glioblastoma multiforme(80;0.202)		TCTGAATAGAGTTTACTTTTT	0.368000													17	46					0	0	1	0	0
ETV6	2120	broad.mit.edu	37	12	12038866	12038866	+	Missense_Mutation	SNP	A	A	G			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr12:12038866A>G	ENST00000396373.4	+	7	1433	c.1159A>G	c.(1159-1161)Aca>Gca	p.T387A		NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	387						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				ACAGAACAGAACAAACATGAC	0.418000			T	"""NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"""	"""congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"""								7	74					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41682030	41682030	+	Frame_Shift_Del	DEL	A	A	-			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr4:41682030delA	ENST00000313860.7	+	19	2429	c.2375delA	c.(2374-2376)tcfs	p.Y792fs	LIMCH1_ENST00000509277.1_Frame_Shift_Del_p.Y625fs|LIMCH1_ENST00000512946.1_Frame_Shift_Del_p.Y792fs|LIMCH1_ENST00000396595.3_Frame_Shift_Del_p.Y637fs|LIMCH1_ENST00000512820.1_Frame_Shift_Del_p.Y804fs|LIMCH1_ENST00000381753.4_Frame_Shift_Del_p.Y625fs|LIMCH1_ENST00000514096.1_Frame_Shift_Del_p.Y632fs|LIMCH1_ENST00000513024.1_Frame_Shift_Del_p.Y645fs|LIMCH1_ENST00000503057.1_Frame_Shift_Del_p.Y1176fs|LIMCH1_ENST00000512632.1_Frame_Shift_Del_p.Y715fs|LIMCH1_ENST00000511496.1_Frame_Shift_Del_p.Y632fs|LIMCH1_ENST00000508501.1_Frame_Shift_Del_p.Y791fs	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	792	Glu-rich.				actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						CAGGAGAGATACCAGAAGGAG	0.448													2	4	---	---	---	---					
SP8	221833	broad.mit.edu	37	7	20824941	20824943	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr7:20824941_20824943delGCC	ENST00000361443.4	-	3	676_678	c.439_441delGGC	c.(439-441)del	p.G147del	SP8_ENST00000418710.2_In_Frame_Del_p.G165del	NM_198956.2	NP_945194.1	Q8IXZ3	SP8_HUMAN	Sp8 transcription factor	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G165delG(1)|p.G147delG(1)		NS(1)|central_nervous_system(1)|large_intestine(2)|lung(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	8						GCGCGGAGGAgccgccgccgccg	0.729													5	3	---	---	---	---					
CREB3L2	64764	broad.mit.edu	37	7	137569752	137569752	+	Frame_Shift_Del	DEL	G	G	-			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr7:137569752delG	ENST00000330387.6	-	10	1610	c.1259delC	c.(1258-1260)aafs	p.T420fs	CREB3L2_ENST00000456390.1_Frame_Shift_Del_p.T420fs	NM_194071.3	NP_919047.2	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like 2	420					chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	breast(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						CACGGAGGCTGTGTAGGGCTC	0.532			T	FUS	fibromyxoid sarcoma								16	71	---	---	---	---					
ZNF408	79797	broad.mit.edu	37	11	46727386	46727386	+	Frame_Shift_Del	DEL	G	G	-			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr11:46727386delG	ENST00000311764.2	+	5	2366	c.2136delG	c.(2134-2136)gafs	p.E712fs		NM_001184751.1|NM_024741.2	NP_001171680.1|NP_079017.1	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	712					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CCTGGGCAGAGGTGGTGGAGG	0.572													2	4	---	---	---	---					
ZNF568	374900	broad.mit.edu	37	19	37487845	37487845	+	Frame_Shift_Del	DEL	A	A	-			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chr19:37487845delA	ENST00000455427.2	+	9	1389	c.1060delA	c.(1060-1062)ctfs	p.T354fs		NM_001204839.1	NP_001191768.1	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	441					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(9)|ovary(1)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAGGATCCATACTGATGAGAA	0.468													2	4	---	---	---	---					
SLC38A5	92745	broad.mit.edu	37	X	48317961	48317961	+	Frame_Shift_Del	DEL	G	G	-			TCGA-J9-A8CK-01A-11D-A34U-08	TCGA-J9-A8CK-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc4c0fab-2cb2-4203-a0ed-c5fef2446f5e	aca8551c-6477-4cd2-a7d0-72b093c56a69	g.chrX:48317961delG	ENST00000376876.3	-	15	2121	c.1278delC	c.(1276-1278)ccfs	p.P426fs	SLC38A5_ENST00000480105.1_5'UTR|SLC38A5_ENST00000376875.1_Frame_Shift_Del_p.P375fs|SLC38A5_ENST00000317669.5_Frame_Shift_Del_p.P426fs			Q8WUX1	S38A5_HUMAN	solute carrier family 38, member 5	426					cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				breast(1)|cervix(1)|endometrium(6)|large_intestine(2)|lung(5)|ovary(3)|skin(1)	19						CCACCTCAGAGGGTACAATGC	0.567													2	4	---	---	---	---