Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GABRB3	2562	broad.mit.edu	37	15	26866590	26866590	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr15:26866590C>T	ENST00000541819.2	-	5	602	c.500G>A	c.(499-501)cGa>cAa	p.R167Q	GABRB3_ENST00000400188.3_Missense_Mutation_p.R40Q|GABRB3_ENST00000311550.5_Missense_Mutation_p.R111Q|GABRB3_ENST00000545868.1_Missense_Mutation_p.R26Q|GABRB3_ENST00000299267.4_Missense_Mutation_p.R111Q			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	111					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GTCAGCCACTCGATTGTCAAG	0.448000													7	52					0	0	1	0	0
E4F1	1877	broad.mit.edu	37	16	2284613	2284613	+	Silent	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr16:2284613C>T	ENST00000301727.4	+	11	1671	c.1623C>T	c.(1621-1623)caC>caT	p.H541H	E4F1_ENST00000564139.1_Silent_p.H541H|E4F1_ENST00000565090.1_Intron	NM_004424.3	NP_004415.2	Q66K89	E4F1_HUMAN	E4F transcription factor 1	541	Interaction with BMI1.|Mediates interaction with CDKN2A.|Mediates interaction with TP53.				cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						TCAGGACACACCTGGAGGAGA	0.632000													3	8					0	0	1	0	0
RPS6KA3	6197	broad.mit.edu	37	X	20190906	20190906	+	Silent	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chrX:20190906C>T	ENST00000379565.3	-	15	1518	c.1311G>A	c.(1309-1311)aaG>aaA	p.K437K	RPS6KA3_ENST00000544447.1_Silent_p.K409K|RPS6KA3_ENST00000479809.1_5'UTR|RPS6KA3_ENST00000540702.1_Silent_p.K408K|RPS6KA3_ENST00000379548.4_Silent_p.K407K	NM_004586.2	NP_004577.1	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 3	437	Protein kinase 2.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(14)|lung(7)|ovary(1)|stomach(1)	41						GTATACATCTCTTGCAAACAG	0.318000													8	22					0	0	1	0	0
DRP2	1821	broad.mit.edu	37	X	100511155	100511155	+	Silent	SNP	G	G	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chrX:100511155G>A	ENST00000395209.3	+	21	2822	c.2295G>A	c.(2293-2295)cgG>cgA	p.R765R	DRP2_ENST00000402866.1_Silent_p.R765R|DRP2_ENST00000538510.1_Silent_p.R765R|DRP2_ENST00000541709.1_Silent_p.R687R	NM_001939.2	NP_001930.2	Q13474	DRP2_HUMAN	dystrophin related protein 2	765					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding	p.R762R(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	31						TCACAGACCGGGAGCCAGCCT	0.577000													40	21					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	81714091	81714091	+	Missense_Mutation	SNP	A	A	C			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr7:81714091A>C	ENST00000356860.3	-	7	990	c.652T>G	c.(652-654)Tat>Gat	p.Y218D	CACNA2D1_ENST00000423588.1_Missense_Mutation_p.Y218D|CACNA2D1_ENST00000356253.5_Missense_Mutation_p.Y218D	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	218						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CTACCTGGATAATATCGAGCT	0.418000													19	35					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802145	185802145	+	Nonsense_Mutation	SNP	T	T	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr2:185802145T>A	ENST00000302277.6	+	4	2616	c.2022T>A	c.(2020-2022)tgT>tgA	p.C674*		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	674						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AAGAAATGTGTAAAACATGGA	0.318000													6	93					0	0	1	0	0
BFSP1	631	broad.mit.edu	37	20	17479638	17479638	+	Silent	SNP	G	G	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr20:17479638G>A	ENST00000377873.3	-	6	822	c.783C>T	c.(781-783)gaC>gaT	p.D261D	BFSP1_ENST00000544874.1_Silent_p.D122D|BFSP1_ENST00000536626.1_Silent_p.D122D|BFSP1_ENST00000377868.2_Silent_p.D136D	NM_001195.3	NP_001186.1	Q12934	BFSP1_HUMAN	beaded filament structural protein 1, filensin	261	Coil 2.|Rod.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)|stomach(1)	18						GAATCTCATCGTCATAACACT	0.483000													11	102					0	0	1	0	0
PCDHGA9	0	broad.mit.edu	37	5	140783471	140783471	+	Missense_Mutation	SNP	G	G	C			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr5:140783471G>C	ENST00000573521.1	+	1	952	c.952G>C	c.(952-954)Gaa>Caa	p.E318Q	PCDHGA8_ENST00000398604.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018921.2|NM_032089.1	NP_061744.1|NP_114478.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTATGAAATGGAAATACAAGC	0.358000													79	67					0	0	1	0	0
TPTE2P6	0	broad.mit.edu	37	13	25168432	25168432	+	RNA	SNP	T	T	C	rs149337771	by1000genomes	TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr13:25168432T>C	ENST00000453498.1	+	0	1104																											TTGAAACAGCTGGTGTATTAA	0.373000													4	31					0	0	1	0	0
MIR888	0	broad.mit.edu	37	X	145076301	145076301	+	RNA	SNP	G	G	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chrX:145076301G>A	ENST00000401186.1	-	0	77					NR_030592.1																						AGTGTACTTGGTGAGCCTTCC	0.498000													4	32					0	0	1	0	0
KCNJ10	3766	broad.mit.edu	37	1	160012031	160012031	+	Missense_Mutation	SNP	C	C	G			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr1:160012031C>G	ENST00000368089.3	-	2	518	c.292G>C	c.(292-294)Gag>Cag	p.E98Q	KCNJ10_ENST00000509700.1_5'UTR	NM_002241.4	NP_002232.2	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 10	98						integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)	17	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGGTCCAGCTCCAGCAGGTCC	0.582000													26	56					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193207583	193207583	+	Missense_Mutation	SNP	T	T	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr3:193207583T>A	ENST00000342695.4	-	7	996	c.674A>T	c.(673-675)tAt>tTt	p.Y225F	ATP13A4_ENST00000392443.3_Missense_Mutation_p.Y225F|ATP13A4_ENST00000295548.3_Missense_Mutation_p.Y225F	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	225					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GGCAAAAGCATATTCCTTATA	0.323000													4	164					0	0	1	0	0
VIPAS39	63894	broad.mit.edu	37	14	77917637	77917637	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr14:77917637C>T	ENST00000553888.1	-	4	746	c.236G>A	c.(235-237)gGc>gAc	p.G79D	VIPAS39_ENST00000343765.2_Missense_Mutation_p.G79D|VIPAS39_ENST00000448935.2_Intron|VIPAS39_ENST00000557658.1_Missense_Mutation_p.G79D|VIPAS39_ENST00000327028.4_Missense_Mutation_p.G79D|VIPAS39_ENST00000556412.1_Missense_Mutation_p.G105D	NM_001193314.1|NM_001193317.1|NM_022067.3	NP_001180243.1|NP_001180246.1|NP_071350.2			VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog																		GTGGGTTGAGCCGCTATTACC	0.483000													4	157					0	0	1	0	0
IFI16	3428	broad.mit.edu	37	1	158988127	158988127	+	Missense_Mutation	SNP	A	A	G			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr1:158988127A>G	ENST00000295809.7	+	5	913	c.658A>G	c.(658-660)Acc>Gcc	p.T220A	IFI16_ENST00000368131.4_Missense_Mutation_p.T220A|IFI16_ENST00000359709.3_Missense_Mutation_p.T164A|IFI16_ENST00000340979.6_Missense_Mutation_p.T220A|IFI16_ENST00000368132.3_Missense_Mutation_p.T220A|IFI16_ENST00000430894.2_Missense_Mutation_p.T168A|IFI16_ENST00000448393.2_Missense_Mutation_p.T220A			Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	220	HIN-200 1.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0429)					TGAATATGAGACCCCAGAAAT	0.403000													28	29					0	0	1	0	0
MYRIP	25924	broad.mit.edu	37	3	40231654	40231654	+	Silent	SNP	G	G	A	rs146724522		TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr3:40231654G>A	ENST00000302541.6	+	10	1707	c.1365G>A	c.(1363-1365)tcG>tcA	p.S455S	MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000425621.1_Silent_p.S455S|MYRIP_ENST00000444716.1_Silent_p.S455S|MYRIP_ENST00000396217.3_Silent_p.S366S|MYRIP_ENST00000539167.1_Silent_p.S268S	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	455	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		GCTCTGACTCGGAGACCTCCT	0.637000													24	32					0	0	1	0	0
DPPA5	340168	broad.mit.edu	37	6	74063588	74063588	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr6:74063588G>A	ENST00000370370.3	-	2	349	c.280C>T	c.(280-282)Cgc>Tgc	p.R94C		NM_001025290.2	NP_001020461.1	A6NC42	DPPA5_HUMAN	developmental pluripotency associated 5	94					multicellular organismal development	cytoplasm	RNA binding			NS(1)|endometrium(1)|lung(5)	7						CGCTCCTGGCGCTGGCGGTGC	0.632000													5	21					0	0	1	0	0
GRIN1	2902	broad.mit.edu	37	9	140051399	140051399	+	Missense_Mutation	SNP	A	A	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr9:140051399A>T	ENST00000371561.3	+	6	1975	c.878A>T	c.(877-879)cAc>cTc	p.H293L	GRIN1_ENST00000315048.3_Missense_Mutation_p.H293L|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000371560.3_Missense_Mutation_p.H314L|GRIN1_ENST00000350902.5_Missense_Mutation_p.H293L|GRIN1_ENST00000371553.3_Missense_Mutation_p.H314L|GRIN1_ENST00000371559.4_Missense_Mutation_p.H293L|GRIN1_ENST00000371555.4_Missense_Mutation_p.H314L|GRIN1_ENST00000371550.4_Missense_Mutation_p.H293L|GRIN1_ENST00000371546.4_Missense_Mutation_p.H314L	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	293					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CAGGCCGTGCACGAGCTCCTC	0.672000													12	18					0	0	1	0	0
PBX3	5090	broad.mit.edu	37	9	128724390	128724390	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr9:128724390G>A	ENST00000373487.4	+	8	1162	c.1082G>A	c.(1081-1083)gGt>gAt	p.G361D	PBX3_ENST00000447726.2_Missense_Mutation_p.G265D|PBX3_ENST00000373483.2_Missense_Mutation_p.G159D|PBX3_ENST00000373489.5_Missense_Mutation_p.G340D|PBX3_ENST00000342287.5_Intron|PBX3_ENST00000538998.1_Intron			P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3	340					anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			biliary_tract(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)	24						GGTTCTTCTGGTTCTTTTAAC	0.443000													7	23					0	0	1	0	0
ALDH6A1	4329	broad.mit.edu	37	14	74537998	74537998	+	Silent	SNP	T	T	C			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr14:74537998T>C	ENST00000553458.1	-	6	728	c.630A>G	c.(628-630)ccA>ccG	p.P210P	ALDH6A1_ENST00000350259.4_Silent_p.P197P|CCDC176_ENST00000553773.1_Intron|AC005484.5_ENST00000492026.1_RNA	NM_001278593.1|NM_005589.2	NP_001265522.1|NP_005580.1	Q02252	MMSA_HUMAN	aldehyde dehydrogenase 6 family, member A1	210						mitochondrial matrix|nucleus	fatty-acyl-CoA binding|malonate-semialdehyde dehydrogenase (acetylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity			NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|prostate(3)|skin(3)	21				BRCA - Breast invasive adenocarcinoma(234;0.00354)	NADH(DB00157)	CTCGCTCAGATGGTTTCATTA	0.483000													22	36					0	0	1	0	0
PTGIS	5740	broad.mit.edu	37	20	48166725	48166725	+	Splice_Site	SNP	G	G	A	rs147584032	byFrequency	TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr20:48166725G>A	ENST00000244043.4	-	2	105	c.74_splice	c.e2-1	p.R26_splice	PTGIS_ENST00000478971.1_5'UTR	NM_000961.3	NP_000952.1	Q16647	PTGIS_HUMAN	prostaglandin I2 (prostacyclin) synthase	26					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	TCACCAGGTCGCCTACAGAAG	0.542000													9	37					0	0	1	0	0
BRD1	23774	broad.mit.edu	37	22	50217771	50217771	+	Silent	SNP	G	G	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr22:50217771G>A	ENST00000216267.8	-	1	681	c.195C>T	c.(193-195)ctC>ctT	p.L65L	BRD1_ENST00000404034.1_Silent_p.L65L|BRD1_ENST00000404760.1_Silent_p.L65L|BRD1_ENST00000457780.2_Silent_p.L65L	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	65					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CTTGAGCAGTGAGGTCATCTT	0.458000													35	48					0	0	1	0	0
SYN2	6854	broad.mit.edu	37	3	12187209	12187209	+	RNA	SNP	G	G	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr3:12187209G>A	ENST00000432424.2	+	0	730							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						TGCTCATCCGGCAGCATGCAT	0.522000													3	42					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228890233	228890233	+	Silent	SNP	G	G	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr2:228890233G>A	ENST00000392056.3	-	5	364	c.318C>T	c.(316-318)aaC>aaT	p.N106N	SPHKAP_ENST00000344657.5_Silent_p.N106N	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	106						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTGGTGAAACGTTGACCAGTT	0.348000													13	56					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124374511	124374511	+	Silent	SNP	G	G	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr3:124374511G>T	ENST00000360013.3	+	39	5983	c.5856G>T	c.(5854-5856)gtG>gtT	p.V1952V	KALRN_ENST00000428018.2_Silent_p.V223V|KALRN_ENST00000459915.1_Silent_p.V44V|KALRN_ENST00000291478.4_Silent_p.V255V|KALRN_ENST00000393496.1_Silent_p.V293V	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1951	DH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GCATTGTGGTGGAGGTAAGTA	0.493000													8	62					0.335167	0.338933	1	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110412425	110412425	+	Missense_Mutation	SNP	C	C	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr8:110412425C>A	ENST00000378402.5	+	13	1237	c.1133C>A	c.(1132-1134)tCc>tAc	p.S378Y		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	378					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GATTCAGCTTCCTATATTTGG	0.423000										HNSCC(38;0.096)			19	350					1.28384e-07	1.44432e-07	1	1	0
ZNF99	7652	broad.mit.edu	37	19	22941153	22941153	+	Missense_Mutation	SNP	G	G	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr19:22941153G>T	ENST00000397104.3	-	5	1284	c.1285C>A	c.(1285-1287)Cat>Aat	p.H429N	ZNF99_ENST00000596209.1_Missense_Mutation_p.H520N					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GCTGAGAAATGCTTAAAAGCT	0.348000													19	31					6.94344e-10	8.01167e-10	1	1	0
NCSTN	23385	broad.mit.edu	37	1	160321118	160321118	+	Missense_Mutation	SNP	G	G	C			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr1:160321118G>C	ENST00000368063.1	+	7	909	c.629G>C	c.(628-630)tGc>tCc	p.C210S	NCSTN_ENST00000392212.4_Missense_Mutation_p.C210S|NCSTN_ENST00000368065.4_Intron|NCSTN_ENST00000535857.1_Intron|NCSTN_ENST00000459963.1_Intron|NCSTN_ENST00000294785.5_Missense_Mutation_p.C230S			Q92542	NICA_HUMAN	nicastrin	230					amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(2)	34	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACTGCCACCTGCATGCGGCGC	0.537000													4	23					0	0	1	0	0
GIF	2694	broad.mit.edu	37	11	59611368	59611368	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr11:59611368C>T	ENST00000541311.1	-	2	399	c.165G>A	c.(163-165)atG>atA	p.M55I	GIF_ENST00000257248.2_Missense_Mutation_p.M80I			P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	80					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			large_intestine(4)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	17						TGTCGCTGGACATGAGCTGGT	0.542000													5	22					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141310581	141310581	+	Silent	SNP	C	C	G			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr8:141310581C>G	ENST00000389328.4	-	11	2063	c.2049G>C	c.(2047-2049)cgG>cgC	p.R683R	TRAPPC9_ENST00000389327.3_Silent_p.R576R|TRAPPC9_ENST00000438773.2_Silent_p.R585R	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	585					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						TTTTCTTGTTCCGCTCTTCTC	0.463000													3	63					0	0	1	0	0
SUOX	6821	broad.mit.edu	37	12	56397664	56397664	+	Missense_Mutation	SNP	A	A	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr12:56397664A>T	ENST00000394109.3	+	3	1215	c.491A>T	c.(490-492)gAc>gTc	p.D164V	SUOX_ENST00000550478.1_3'UTR|SUOX_ENST00000356124.4_Missense_Mutation_p.D164V|SUOX_ENST00000551841.2_Intron|SUOX_ENST00000266971.3_Missense_Mutation_p.D164V|SUOX_ENST00000548274.1_Missense_Mutation_p.D164V|SUOX_ENST00000394115.2_Missense_Mutation_p.D164V			P51687	SUOX_HUMAN	sulfite oxidase	164						mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)	15			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			AATCCTGAAGACAAGGTAGCC	0.562000													7	59					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23851721	23851721	+	Missense_Mutation	SNP	C	C	G			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr14:23851721C>G	ENST00000405093.3	-	38	5782	c.5712G>C	c.(5710-5712)gaG>gaC	p.E1904D	MYH6_ENST00000356287.3_Missense_Mutation_p.E1904D	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1904					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCTCATCCAGCTCATGCTGCA	0.607000													28	63					0	0	1	0	0
ZNF148	7707	broad.mit.edu	37	3	124951540	124951540	+	Missense_Mutation	SNP	C	C	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr3:124951540C>A	ENST00000360647.4	-	9	2515	c.2030G>T	c.(2029-2031)gGa>gTa	p.G677V	ZNF148_ENST00000485866.1_Missense_Mutation_p.G677V|SLC12A8_ENST00000423114.2_Intron|ZNF148_ENST00000492394.1_Missense_Mutation_p.G677V|ZNF148_ENST00000544464.1_Intron|ZNF148_ENST00000497929.1_5'UTR|ZNF148_ENST00000468369.1_Intron|ZNF148_ENST00000484491.1_Missense_Mutation_p.G677V	NM_021964.2	NP_068799.2	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	677					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)	28						AACTATTAGTCCAAAGTGGGA	0.438000													52	87					1.0331e-37	1.23971e-37	1	1	0
SEMA5B	54437	broad.mit.edu	37	3	122645513	122645513	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr3:122645513C>T	ENST00000195173.4	-	9	1165	c.862G>A	c.(862-864)Gtg>Atg	p.V288M	SEMA5B_ENST00000451055.2_Missense_Mutation_p.V342M|SEMA5B_ENST00000357599.3_Missense_Mutation_p.V288M			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	288	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		TAGGCTGCCACGAAGTTTGGC	0.592000													6	35					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70526274	70526274	+	Nonsense_Mutation	SNP	C	C	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr18:70526274C>A	ENST00000327305.6	-	4	913	c.256G>T	c.(256-258)Gaa>Taa	p.E86*	NETO1_ENST00000580049.1_5'UTR|NETO1_ENST00000397929.1_Nonsense_Mutation_p.E85*|NETO1_ENST00000299430.2_Nonsense_Mutation_p.E85*|NETO1_ENST00000583169.1_Nonsense_Mutation_p.E86*	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	86	CUB 1.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GAGTACTTTTCATCAAAGTAA	0.388000													30	47					1.39806e-14	1.63409e-14	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168115485	168115485	+	Missense_Mutation	SNP	G	G	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr2:168115485G>T	ENST00000409728.1	+	11	2617	c.2528G>T	c.(2527-2529)gGa>gTa	p.G843V	XIRP2_ENST00000409605.1_Missense_Mutation_p.G588V|XIRP2_ENST00000409195.1_3'UTR|XIRP2_ENST00000409273.1_3'UTR|XIRP2_ENST00000409043.1_Missense_Mutation_p.G810V|XIRP2_ENST00000409756.2_Missense_Mutation_p.G810V|XIRP2_ENST00000295237.9_3'UTR|XIRP2_ENST00000420519.1_Missense_Mutation_p.G843V	NM_001199143.1	NP_001186072.1	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GTAAAGGGGGGAAGTTCAATC	0.438000													3	21					0.115264	0.119239	1	1	0
ACSS1	84532	broad.mit.edu	37	20	24993264	24993264	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr20:24993264C>T	ENST00000537502.1	-	10	3026	c.1495G>A	c.(1495-1497)Ggc>Agc	p.G499S	ACSS1_ENST00000432802.2_Intron|ACSS1_ENST00000542618.1_Missense_Mutation_p.G461S|ACSS1_ENST00000323482.4_Missense_Mutation_p.G582S			Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	582					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGGGGGTAGCCAATGACAGCA	0.567000													29	61					0	0	1	0	0
DIAPH1	1729	broad.mit.edu	37	5	140907265	140907265	+	Splice_Site	SNP	C	C	A	rs80342520		TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr5:140907265C>A	ENST00000253811.6	-	24	3292		c.e24-1		DIAPH1_ENST00000389057.5_Splice_Site|DIAPH1_ENST00000389054.3_Splice_Site|DIAPH1_ENST00000518047.1_Splice_Site|DIAPH1_ENST00000398557.4_Splice_Site|DIAPH1_ENST00000520569.1_Splice_Site|DIAPH1_ENST00000398562.2_Splice_Site|DIAPH1_ENST00000398566.3_Splice_Site			O60610	DIAP1_HUMAN	diaphanous-related formin 1						regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(12)|pancreas(1)|skin(2)|stomach(2)	23			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGCAGAAACTaaaaaaaaa	0.358000													4	21					0.000274275	0.000297407	1	1	0
NDUFS2	4720	broad.mit.edu	37	1	161179951	161179951	+	Missense_Mutation	SNP	C	C	G			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr1:161179951C>G	ENST00000392179.4	+	7	992	c.753C>G	c.(751-753)ttC>ttG	p.F251L	NDUFS2_ENST00000465923.1_3'UTR|NDUFS2_ENST00000367993.3_Missense_Mutation_p.F251L|NDUFS2_ENST00000476409.2_Missense_Mutation_p.F153L	NM_001166159.1	NP_001159631.1	O75306	NDUS2_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	251					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)	18	all_cancers(52;1.16e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		NADH(DB00157)	CTAAGAACTTCTCTCTTCGGC	0.448000											OREG0013941	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	23					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152576788	152576788	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr6:152576788G>A	ENST00000367255.5	-	103	19799	c.19198C>T	c.(19198-19200)Cgt>Tgt	p.R6400C	SYNE1_ENST00000423061.1_Missense_Mutation_p.R6329C|SYNE1_ENST00000356820.4_Missense_Mutation_p.R924C|SYNE1_ENST00000448038.1_Missense_Mutation_p.R6329C|SYNE1_ENST00000265368.4_Missense_Mutation_p.R6400C|SYNE1_ENST00000341594.5_Missense_Mutation_p.R6012C	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6400					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACAAATAAACGTTCTTCAACG	0.448000										HNSCC(10;0.0054)			9	72					0	0	1	0	0
EDIL3	10085	broad.mit.edu	37	5	83476237	83476237	+	Missense_Mutation	SNP	C	C	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr5:83476237C>A	ENST00000296591.5	-	4	747	c.329G>T	c.(328-330)gGa>gTa	p.G110V	EDIL3_ENST00000380138.3_Missense_Mutation_p.G100V	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	110	EGF-like 2.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		CCCATTAAATCCTCGGGGACA	0.378000													7	51					0.00448238	0.00474605	1	1	0
TRIM60	166655	broad.mit.edu	37	4	165962535	165962535	+	Silent	SNP	C	C	G			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr4:165962535C>G	ENST00000512596.1	+	3	1527	c.1311C>G	c.(1309-1311)ctC>ctG	p.L437L	TRIM60_ENST00000341062.5_Silent_p.L437L|TRIM60_ENST00000508504.1_Silent_p.L437L	NM_152620.2	NP_689833.1	Q495X7	TRI60_HUMAN	tripartite motif containing 60	437	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	29	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		GGTCTATTCTCTATACTTTTA	0.358000													36	88					0	0	1	0	0
NPIPB4	440345	broad.mit.edu	37	16	21854800	21854800	+	Missense_Mutation	SNP	G	G	C			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr16:21854800G>C	ENST00000415645.2	-	4	491	c.452C>G	c.(451-453)aCa>aGa	p.T151R	NPIPB4_ENST00000357370.5_Missense_Mutation_p.T151R|NPIPB4_ENST00000451409.1_5'UTR|NPIPB4_ENST00000539318.1_5'UTR					nuclear pore complex interacting protein family, member B4																		TCTAACTTTTGTTTCCACATG	0.388000													47	202					0	0	1	0	0
FAM134A	79137	broad.mit.edu	37	2	220046151	220046151	+	Missense_Mutation	SNP	A	A	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr2:220046151A>T	ENST00000430297.2	+	7	981	c.845A>T	c.(844-846)gAa>gTa	p.E282V		NM_024293.4	NP_077269.3	Q8NC44	F134A_HUMAN	family with sequence similarity 134, member A	282						endoplasmic reticulum|integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	19		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACAGAGAGTGAAAGCGAGGCA	0.532000													14	45					0	0	1	0	0
METTL13	51603	broad.mit.edu	37	1	171753168	171753168	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr1:171753168C>T	ENST00000361735.3	+	2	708	c.442C>T	c.(442-444)Cgt>Tgt	p.R148C	METTL13_ENST00000367737.5_Missense_Mutation_p.R148C|METTL13_ENST00000458517.1_Missense_Mutation_p.R147C|METTL13_ENST00000362019.3_Missense_Mutation_p.R62C	NM_015935.4	NP_057019.3	Q8N6R0	MTL13_HUMAN	methyltransferase like 13	148							methyltransferase activity|protein binding			breast(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(8)|lung(17)|stomach(3)	41						TGAGGTTGGCCGTGTCCTGCA	0.592000													28	11					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225662683	225662683	+	Nonsense_Mutation	SNP	G	G	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr2:225662683G>A	ENST00000409592.3	-	42	4605	c.4492C>T	c.(4492-4494)Caa>Taa	p.Q1498*	DOCK10_ENST00000258390.7_Nonsense_Mutation_p.Q1504*			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1504							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TGTTGGAGTTGTCTCTGGAAA	0.363000													3	35					0	0	1	0	0
PSMB4	5692	broad.mit.edu	37	1	151372581	151372581	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr1:151372581C>T	ENST00000290541.6	+	2	319	c.265C>T	c.(265-267)Cga>Tga	p.R89*		NM_002796.2	NP_002787.2	P28070	PSB4_HUMAN	proteasome (prosome, macropain) subunit, beta type, 4	89					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			endometrium(1)|lung(9)|ovary(2)|prostate(1)|skin(1)	14	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCGCATTATGCGAGTCAACAA	0.537000													4	188					0	0	1	0	0
CDRT1	374286	broad.mit.edu	37	17	15522583	15522583	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr17:15522583C>T	ENST00000395906.3	-	1	243	c.244G>A	c.(244-246)Gga>Aga	p.G82R	RP11-385D13.1_ENST00000455584.2_Intron	NM_006382.3	NP_006373.2	O95170	CDRT1_HUMAN	CMT1A duplicated region transcript 1	82										endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|stomach(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(2;1.36e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0541)		AAATCCTTTCCCTGTGTGGTC	0.398000													4	126					0	0	1	0	0
FAM49B	51571	broad.mit.edu	37	8	130867925	130867925	+	Silent	SNP	G	G	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr8:130867925G>T	ENST00000519824.2	-	6	643	c.370C>A	c.(370-372)Cga>Aga	p.R124R	FAM49B_ENST00000519540.1_Silent_p.R124R|FAM49B_ENST00000517654.1_Silent_p.R124R|FAM49B_ENST00000519110.1_Silent_p.R124R|FAM49B_ENST00000518879.1_5'UTR|FAM49B_ENST00000522250.1_5'UTR|FAM49B_ENST00000523509.1_Silent_p.R124R|FAM49B_ENST00000522746.1_Silent_p.R124R|FAM49B_ENST00000522941.1_5'UTR|FAM49B_ENST00000401979.2_Silent_p.R124R	NM_016623.4	NP_057707.3	Q9NUQ9	FA49B_HUMAN	family with sequence similarity 49, member B	124								p.R124*(1)		kidney(1)|large_intestine(6)|lung(4)|prostate(1)	12	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			GCCTGCTCTCGCTCTAGATGC	0.398000													4	120					0.000602214	0.00064523	1	1	0
GRM8	0	broad.mit.edu	37	7	126086370	126086370	+	Silent	SNP	A	A	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr7:126086370A>T	ENST00000339582.2	-	10	3295	c.2487T>A	c.(2485-2487)tcT>tcA	p.S829S	GRM8_ENST00000444921.2_Silent_p.S829S|GRM8_ENST00000358373.3_Silent_p.S829S			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	829					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GCATGCCCAGAGATACTGAAG	0.398000										HNSCC(24;0.065)			30	49					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128335737	128335737	+	Silent	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr2:128335737C>T	ENST00000389524.4	+	9	932	c.879C>T	c.(877-879)aaC>aaT	p.N293N	MYO7B_ENST00000409816.2_Silent_p.N293N|MYO7B_ENST00000428314.1_Silent_p.N293N			Q6PIF6	MYO7B_HUMAN	myosin VIIB	293	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		AGGGGCTCAACGACGCCAAGG	0.632000													9	16					0	0	1	0	0
MFSD9	84804	broad.mit.edu	37	2	103353178	103353178	+	Missense_Mutation	SNP	T	T	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr2:103353178T>A	ENST00000258436.5	-	1	135	c.92A>T	c.(91-93)gAg>gTg	p.E31V		NM_032718.3	NP_116107.3	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing 9	31					transmembrane transport	integral to membrane|plasma membrane	transporter activity			breast(3)|large_intestine(7)|liver(1)|lung(6)|ovary(2)|skin(1)	20						AGCCTCCGCCTCGGTTCCTGT	0.672000													6	26					0	0	1	0	0
CA14	23632	broad.mit.edu	37	1	150234607	150234607	+	Missense_Mutation	SNP	T	T	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr1:150234607T>A	ENST00000369111.4	+	4	1277	c.307T>A	c.(307-309)Tat>Aat	p.Y103N		NM_012113.1	NP_036245.1	Q9ULX7	CAH14_HUMAN	carbonic anhydrase XIV	103						integral to membrane	carbonate dehydratase activity|metal ion binding			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	18	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			TCCCCGAAAATATGTAGCTGC	0.537000													5	96					0	0	1	0	0
TLK1	9874	broad.mit.edu	37	2	171884862	171884862	+	Missense_Mutation	SNP	C	C	G			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr2:171884862C>G	ENST00000442919.2	-	12	1694	c.1079G>C	c.(1078-1080)gGa>gCa	p.G360A	TLK1_ENST00000431350.2_Missense_Mutation_p.G408A|TLK1_ENST00000434911.2_Missense_Mutation_p.G312A|TLK1_ENST00000521943.1_Missense_Mutation_p.G360A|TLK1_ENST00000360843.3_Missense_Mutation_p.G429A	NM_012290.4	NP_036422.3	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1	408					cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|liver(3)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						TTTGAGATGTCCTAGTCTAAG	0.303000													5	22					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100676261	100676261	+	Missense_Mutation	SNP	C	C	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr7:100676261C>A	ENST00000306151.4	+	3	1628	c.1564C>A	c.(1564-1566)Ccg>Acg	p.P522T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	522	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGCACCATGCCGGTGGCCAG	0.498000													8	744					1.12685e-05	1.25206e-05	1	1	0
TTN	7273	broad.mit.edu	37	2	179485645	179485645	+	Missense_Mutation	SNP	A	A	G			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr2:179485645A>G	ENST00000589042.1	-	247	45916	c.45692T>C	c.(45691-45693)gTc>gCc	p.V15231A	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V13590A|TTN_ENST00000460472.2_Missense_Mutation_p.V6166A|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V6291A|TTN_ENST00000342992.6_Missense_Mutation_p.V12663A|TTN_ENST00000342175.6_Missense_Mutation_p.V6358A	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13590	Fibronectin type-III 11.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAGTATTGACTTCACAGTT	0.403000													10	55					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159284004	159284004	+	Missense_Mutation	SNP	G	G	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr1:159284004G>A	ENST00000332217.5	-	1	445	c.446C>T	c.(445-447)tCa>tTa	p.S149L		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	149					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					AATCCCCAGTGATCCAGAGGC	0.512000													7	50					0	0	1	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149212575	149212575	+	Silent	SNP	C	C	G			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr5:149212575C>G	ENST00000309241.5	+	5	971	c.939C>G	c.(937-939)ccC>ccG	p.P313P	PPARGC1B_ENST00000360453.4_Silent_p.P274P|PPARGC1B_ENST00000403750.1_Silent_p.P249P|PPARGC1B_ENST00000394320.3_Silent_p.P313P	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	313					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			AGCCACTCCCCAAGGCCTGCA	0.627000													8	73					0	0	1	0	0
KDM2A	22992	broad.mit.edu	37	11	66985327	66985327	+	Silent	SNP	G	G	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr11:66985327G>A	ENST00000529006.2	+	9	1259	c.813G>A	c.(811-813)aaG>aaA	p.K271K	KDM2A_ENST00000526258.1_3'UTR|KDM2A_ENST00000398645.2_Silent_p.K271K	NM_012308.2	NP_036440.1	Q9Y2K7	KDM2A_HUMAN	lysine (K)-specific demethylase 2A	271	JmjC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|urinary_tract(2)	36						TTGAGCTCAAGCAGGGCTATA	0.458000													5	50					0	0	1	0	0
CD1C	911	broad.mit.edu	37	1	158262542	158262542	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr1:158262542C>T	ENST00000368170.3	+	4	1046	c.767C>T	c.(766-768)cCt>cTt	p.P256L		NM_001765.2	NP_001756.2	P29017	CD1C_HUMAN	CD1c molecule	256	Ig-like.				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			NS(1)|endometrium(3)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	39	all_hematologic(112;0.0378)					GATATTCTTCCTAATGCTGAT	0.527000													25	57					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151855999	151855999	+	Silent	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr7:151855999C>T	ENST00000355193.2	-	44	11837	c.11619G>A	c.(11617-11619)gaG>gaA	p.E3873E	KMT2C_ENST00000262189.6_Silent_p.E3873E					lysine (K)-specific methyltransferase 2C																		CTTGTTTCTCCTCTTCGTCCT	0.458000													55	227					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117742298	117742298	+	Silent	SNP	A	A	G			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chrX:117742298A>G	ENST00000276204.6	+	26	2930	c.2856A>G	c.(2854-2856)ttA>ttG	p.L952L	DOCK11_ENST00000276202.7_Silent_p.L952L			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	952					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						CAGATTTTTTATCAATAAACA	0.418000													27	99					0	0	1	0	0
VAV3	10451	broad.mit.edu	37	1	108231002	108231002	+	Splice_Site	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr1:108231002C>T	ENST00000370056.4	-	18	2006		c.e18+1		VAV3_ENST00000544443.1_Splice_Site|VAV3_ENST00000527011.1_Splice_Site|VAV3_ENST00000343258.4_Splice_Site|VAV3_ENST00000415432.2_Splice_Site|VAV3_ENST00000371846.4_Splice_Site	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor						angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		GTTAATCTTACCTCTGGTAGT	0.328000													14	28					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128134112	128134112	+	Silent	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr6:128134112C>T	ENST00000368250.1	-	5	1935	c.1437G>A	c.(1435-1437)ccG>ccA	p.P479P	THEMIS_ENST00000368248.2_Silent_p.P558P|THEMIS_ENST00000543064.1_Silent_p.P558P|THEMIS_ENST00000537166.1_Silent_p.P523P			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	558	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						AGGGGTGTTTCGGAGGGCGAG	0.483000													37	71					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31409184	31409184	+	Silent	SNP	G	G	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr16:31409184G>T	ENST00000389202.2	+	5	430	c.381G>T	c.(379-381)ctG>ctT	p.L127L		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	127					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity	p.G128C(1)		breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GCCTCCTGCTGGGCTCGCGCT	0.642000													5	17					0.184627	0.188823	1	1	0
ASTE1	28990	broad.mit.edu	37	3	130743334	130743334	+	Silent	SNP	G	G	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr3:130743334G>A	ENST00000264992.3	-	3	1258	c.817C>T	c.(817-819)Cta>Tta	p.L273L	ASTE1_ENST00000514044.1_Silent_p.L273L	NM_014065.2	NP_054784.2	Q2TB18	ASTE1_HUMAN	asteroid homolog 1 (Drosophila)	273					DNA repair		nuclease activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)	22						ACATTATCTAGTGCTTCGGTA	0.458000													20	49					0	0	1	0	0
PKNOX2	63876	broad.mit.edu	37	11	125255503	125255503	+	Missense_Mutation	SNP	A	A	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr11:125255503A>T	ENST00000298282.9	+	6	555	c.284A>T	c.(283-285)cAg>cTg	p.Q95L	PKNOX2_ENST00000530517.1_3'UTR|PKNOX2_ENST00000542175.1_Missense_Mutation_p.Q31L	NM_022062.2	NP_071345.2	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	95						nucleus	sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(14)|ovary(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	29		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		CAGGCCACCCAGGGCTCTGAG	0.557000													22	51					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178928235	178928235	+	Missense_Mutation	SNP	A	A	C			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr3:178928235A>C	ENST00000263967.3	+	9	1578	c.1421A>C	c.(1420-1422)gAg>gCg	p.E474A		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	474	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCATGCTTAGAGTTGGAGTTT	0.373000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			37	53					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70989610	70989610	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr14:70989610C>T	ENST00000256389.3	-	2	2259	c.2015G>A	c.(2014-2016)cGt>cAt	p.R672H	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	622					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		ACACTTCTTACGGATGCAGAT	0.468000													73	150					0	0	1	0	0
COG1	9382	broad.mit.edu	37	17	71189377	71189377	+	Missense_Mutation	SNP	C	C	T			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr17:71189377C>T	ENST00000299886.4	+	1	249	c.169C>T	c.(169-171)Cgc>Tgc	p.R57C	RP11-143K11.5_ENST00000580671.1_RNA	NM_018714.2	NP_061184.1	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	57					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18			LUSC - Lung squamous cell carcinoma(166;0.197)			CGAACGGTACCGCGACCTGAT	0.697000													3	14					0	0	1	0	0
CARD9	64170	broad.mit.edu	37	9	139265071	139265071	+	Missense_Mutation	SNP	G	G	C			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr9:139265071G>C	ENST00000371732.5	-	5	875	c.710C>G	c.(709-711)gCc>gGc	p.A237G	CARD9_ENST00000371734.3_Missense_Mutation_p.A237G|CARD9_ENST00000315908.7_Missense_Mutation_p.A237G	NM_052813.4	NP_434700.2	Q9H257	CARD9_HUMAN	caspase recruitment domain family, member 9	237					positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|pancreas(1)|prostate(3)|skin(1)	15		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		CTGCTCCATGGCGTGCCTGAG	0.652000													7	40					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8651510	8651510	+	Nonsense_Mutation	SNP	G	G	A			TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr19:8651510G>A	ENST00000270328.4	-	19	2601	c.2335C>T	c.(2335-2337)Cga>Tga	p.R779*	ADAMTS10_ENST00000595838.1_Nonsense_Mutation_p.R266*|ADAMTS10_ENST00000597188.1_Nonsense_Mutation_p.R779*			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	779	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.R779*(1)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						GGCCCCTGTCGCAGTTGAAAG	0.642000											OREG0025221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	55					0	0	1	0	0
RP11-1252I4.2	0	broad.mit.edu	37	5	177398373	177398396	+	RNA	DEL	AGGACGAAGAGCTGGAGAGCGCCA	AGGACGAAGAGCTGGAGAGCGCCA	-	rs70994948		TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr5:177398373_177398396delAGGACGAAGAGCTGGAGAGCGCCA	ENST00000511650.1	+	0	145																											GTCCCCGGGGAGGACGAAGAGCTGGAGAGCGCCAAGGACGACGA	0.683													5	3	---	---	---	---					
GALR2	8811	broad.mit.edu	37	17	74073448	74073457	+	Frame_Shift_Del	DEL	GTCCTGGCCC	GTCCTGGCCC	-	rs67693166		TCGA-J9-A8CL-01A-11D-A34U-08	TCGA-J9-A8CL-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ca1f9f2e-7a09-4e2d-bb99-c881a34a8da2	e5a23b9d-18a0-4cb4-8743-3d53fc3c45b4	g.chr17:74073448_74073457delGTCCTGGCCC	ENST00000329003.3	+	2	1190_1199	c.1100_1109delGTCCTGGCCC	c.(1099-1110)tgfs	p.CPGP367fs		NM_003857.2	NP_003848.1	O43603	GALR2_HUMAN	galanin receptor 2	367					digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity			cervix(1)|lung(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						CTCGAGCCCTGTCCTGGCCCGTCCTGGCAG	0.657													6	2	---	---	---	---