Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CYP4Z2P	0	broad.mit.edu	37	1	47364570	47364570	+	RNA	SNP	C	C	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr1:47364570C>T	ENST00000505841.1	-	0	266					NR_002788.2																						TGAAGAACATCGTAAAGGGTC	0.433000													14	52					0	0	1	0	0
SLC30A8	169026	broad.mit.edu	37	8	118169991	118169991	+	Silent	SNP	C	C	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr8:118169991C>T	ENST00000427715.2	+	7	767	c.333C>T	c.(331-333)taC>taT	p.Y111Y	SLC30A8_ENST00000521243.1_Silent_p.Y111Y|SLC30A8_ENST00000519688.1_Silent_p.Y111Y|SLC30A8_ENST00000456015.2_Silent_p.Y160Y	NM_001172813.1|NM_001172815.1	NP_001166284.1|NP_001166286.1	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	160					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			TGCTAGTGTACCTGGCATGTG	0.527000													5	230					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160099088	160099088	+	Silent	SNP	T	T	C			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr1:160099088T>C	ENST00000361216.3	+	11	1448	c.1359T>C	c.(1357-1359)gcT>gcC	p.A453A	ATP1A2_ENST00000392233.3_Silent_p.A453A|ATP1A2_ENST00000472488.1_3'UTR	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	453					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CTGAGTCAGCTCTGCTCAAGT	0.532000													29	223					0	0	1	0	0
SPIB	6689	broad.mit.edu	37	19	50926944	50926944	+	Missense_Mutation	SNP	T	T	G			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr19:50926944T>G	ENST00000595883.1	+	5	447	c.422T>G	c.(421-423)cTg>cGg	p.L141R	SPIB_ENST00000270632.7_Missense_Mutation_p.L141R|SPIB_ENST00000439922.2_Missense_Mutation_p.L50R|SPIB_ENST00000596074.1_Silent_p.P69P|SPIB_ENST00000597855.1_Silent_p.P129P	NM_001243999.1|NM_001244000.1|NM_003121.4	NP_001230928.1|NP_001230929.1|NP_003112.2	Q01892	SPIB_HUMAN	Spi-B transcription factor (Spi-1/PU.1 related)	141					regulation of transcription from RNA polymerase II promoter	cytoplasm|microtubule cytoskeleton|nucleus	sequence-specific DNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)	14		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		AGCCCTGCCCTGGAGGTCTCG	0.667000													13	24					0	0	1	0	0
MICALL2	79778	broad.mit.edu	37	7	1484421	1484421	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr7:1484421C>T	ENST00000297508.7	-	6	1460	c.1285G>A	c.(1285-1287)Ggc>Agc	p.G429S	MICALL2_ENST00000405088.4_Missense_Mutation_p.G217S	NM_182924.3	NP_891554.1	Q8IY33	MILK2_HUMAN	MICAL-like 2	429						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(8)|ovary(2)|skin(2)	19		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		AGGCTGGTGCCGGGGGGCACT	0.632000													5	58					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179393601	179393601	+	Nonsense_Mutation	SNP	A	A	C			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr2:179393601A>C	ENST00000589042.1	-	360	107101	c.106877T>G	c.(106876-106878)tTa>tGa	p.L35626*	TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000587568.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000604571.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.L33058*|TTN-AS1_ENST00000592182.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.L26753*|TTN_ENST00000359218.5_Nonsense_Mutation_p.L26686*|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.L33985*|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.L26561*|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000587944.1_RNA|TTN-AS1_ENST00000585625.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000431259.2_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	33985							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTGGCTTTTAAAACCAGTCT	0.433000													10	21					0	0	1	0	0
PLAA	9373	broad.mit.edu	37	9	26926460	26926460	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr9:26926460C>T	ENST00000397292.3	-	5	1081	c.664G>A	c.(664-666)Gag>Aag	p.E222K	PLAA_ENST00000520884.1_Missense_Mutation_p.E222K	NM_001031689.2	NP_001026859.1	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	222					phospholipid metabolic process|signal transduction		phospholipase A2 activator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	17		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		TCAAGACACTCGCCAGTGATT	0.328000													31	45					0	0	1	0	0
PCDHA9	0	broad.mit.edu	37	5	140229523	140229523	+	Silent	SNP	C	C	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr5:140229523C>T	ENST00000378122.3	+	1	2167	c.1443C>T	c.(1441-1443)gaC>gaT	p.D481D	PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA9_ENST00000532602.1_Silent_p.D481D|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCGCGGGACGCTGACGCGC	0.657000													34	82					0	0	1	0	0
CTD-2666L21.1	0	broad.mit.edu	37	19	12318385	12318385	+	RNA	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr19:12318385G>A	ENST00000426044.1	+	0	127																											CATGGTGACAGCTAATTAGAT	0.343000													3	8					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85962835	85962835	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr10:85962835G>A	ENST00000372117.3	+	8	842	c.739G>A	c.(739-741)Gtg>Atg	p.V247M	CDHR1_ENST00000440770.2_Missense_Mutation_p.V6M|CDHR1_ENST00000332904.3_Missense_Mutation_p.V247M	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	247	Cadherin 3.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						CCCTGTCTTCGTGGGCACACC	0.617000													13	107					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29624093	29624093	+	Splice_Site	SNP	G	G	T	rs75468660		TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr20:29624093G>T	ENST00000278882.3	+	4	496		c.e4+1		FRG1B_ENST00000358464.4_Splice_Site|FRG1B_ENST00000439954.2_Splice_Site														p.?(6)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						CTGATTCCAGGTGAGCTTATG	0.299000													4	23					0.00116845	0.00120614	1	1	0
GNB1L	0	broad.mit.edu	37	22	19789726	19789726	+	Missense_Mutation	SNP	G	G	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr22:19789726G>T	ENST00000329517.6	-	7	766	c.530C>A	c.(529-531)tCc>tAc	p.S177Y	GNB1L_ENST00000405009.1_Missense_Mutation_p.S177Y|GNB1L_ENST00000403325.1_Missense_Mutation_p.S177Y|GNB1L_ENST00000460402.1_5'UTR	NM_053004.2	NP_443730.1	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 1-like	177					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(3)|skin(1)	12	Colorectal(54;0.0993)					GAGTGGGCGGGAGCTGCAGTC	0.637000													14	65					1.05317e-09	1.16212e-09	1	1	0
TVP23C	201158	broad.mit.edu	37	17	15441469	15441469	+	Splice_Site	SNP	C	C	T	rs139351610	by1000genomes	TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr17:15441469C>T	ENST00000584811.1	-	7	1815		c.e7-2		TVP23C_ENST00000519970.1_Intron|TVP23C_ENST00000428082.2_Splice_Site|TVP23C_ENST00000225576.3_Intron|TVP23C-CDRT4_ENST00000522212.2_Intron|TVP23C_ENST00000438826.3_Splice_Site					trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)																		TCCAGTGTTCCGCAAAAGACA	0.393000													6	91					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158618311	158618311	+	Silent	SNP	G	G	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr1:158618311G>T	ENST00000368148.3	-	26	3882	c.3702C>A	c.(3700-3702)ccC>ccA	p.P1234P	SPTA1_ENST00000368147.3_Silent_p.P1234P	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1234					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TATCTCCCAGGGGTACGAGGT	0.493000													43	71					6.1244e-12	6.87652e-12	1	1	0
EYS	346007	broad.mit.edu	37	6	66205285	66205285	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr6:66205285C>T	ENST00000503581.1	-	4	556	c.19G>A	c.(19-21)Gtc>Atc	p.V7I	EYS_ENST00000370618.3_Missense_Mutation_p.V7I|EYS_ENST00000342421.5_Missense_Mutation_p.V7I|EYS_ENST00000370621.3_Missense_Mutation_p.V7I|EYS_ENST00000393380.2_Missense_Mutation_p.V7I|EYS_ENST00000370616.2_Missense_Mutation_p.V7I	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	7					response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						CTCAGAATGACGATTGATTTG	0.368000													14	39					0	0	1	0	0
ABTB1	80325	broad.mit.edu	37	3	127399141	127399141	+	Silent	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr3:127399141G>A	ENST00000468137.1	+	11	1450	c.834G>A	c.(832-834)gcG>gcA	p.A278A	ABTB1_ENST00000453791.2_Silent_p.A278A|ABTB1_ENST00000393363.3_Silent_p.A278A|ABTB1_ENST00000232744.8_Silent_p.A420A			Q969K4	ABTB1_HUMAN	ankyrin repeat and BTB (POZ) domain containing 1	420	BTB 2.					cytoplasm|nucleolus|plasma membrane	translation elongation factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	10						TCGTGGAGGCGGTGAAGGAGG	0.672000													10	28					0	0	1	0	0
WDR11	55717	broad.mit.edu	37	10	122662580	122662580	+	Nonsense_Mutation	SNP	G	G	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr10:122662580G>T	ENST00000263461.6	+	23	3013	c.2767G>T	c.(2767-2769)Gaa>Taa	p.E923*	WDR11_ENST00000604509.1_3'UTR	NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	923						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						CTATGGTGATGAATCGGAGCT	0.542000													8	44					0.000274275	0.000287764	1	1	0
CCND3	896	broad.mit.edu	37	6	41908118	41908118	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr6:41908118C>A	ENST00000511642.1	-	2	912	c.161G>T	c.(160-162)cGc>cTc	p.R54L	CCND3_ENST00000415497.2_Intron|CCND3_ENST00000372987.4_Missense_Mutation_p.R85L|CCND3_ENST00000510503.1_Missense_Mutation_p.R54L|CCND3_ENST00000511686.1_Intron|CCND3_ENST00000414200.2_Intron|CCND3_ENST00000372988.4_Missense_Mutation_p.R54L|CCND3_ENST00000372991.4_Missense_Mutation_p.R135L			P30281	CCND3_HUMAN	cyclin D3	135	Cyclin N-terminal.				cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(13)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	20	Colorectal(47;0.121)		Epithelial(12;0.000178)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCGCAACTGGCGGGGAGAGAC	0.597000			T	IGH@	MM								52	68					4.32865e-36	4.94703e-36	1	1	0
TRIOBP	11078	broad.mit.edu	37	22	38119859	38119859	+	Silent	SNP	C	C	T	rs66505048		TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr22:38119859C>T	ENST00000406386.3	+	7	1551	c.1296C>T	c.(1294-1296)tgC>tgT	p.C432C	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	432					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding	p.C432C(6)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GAACATCCTGCGCCCAGCGGG	0.582000													6	210					0	0	1	0	0
SYNE3	161176	broad.mit.edu	37	14	95909521	95909521	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr14:95909521C>T	ENST00000334258.5	-	10	1896	c.1882G>A	c.(1882-1884)Gac>Aac	p.D628N	SYNE3_ENST00000554873.1_Missense_Mutation_p.D385N|SYNE3_ENST00000557275.1_Missense_Mutation_p.D628N	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						GCCTGGAAGTCGGAGGAAAGC	0.627000													15	27					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88964976	88964976	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr7:88964976G>A	ENST00000333190.4	+	4	3289	c.2680G>A	c.(2680-2682)Ggg>Agg	p.G894R		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	894						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GTGTAACTCCGGGAATATCAG	0.438000										HNSCC(36;0.09)			39	71					0	0	1	0	0
C6orf165	154313	broad.mit.edu	37	6	88173768	88173768	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr6:88173768G>A	ENST00000507897.1	+	13	1752	c.1669G>A	c.(1669-1671)Gta>Ata	p.V557I	C6ORF165_ENST00000369562.4_Missense_Mutation_p.V557I|C6orf165_ENST00000506888.1_3'UTR			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	557										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		TACTCACTCAGTACAAACTGA	0.388000													23	34					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139400029	139400029	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr9:139400029A>G	ENST00000277541.6	-	25	4394	c.4319T>C	c.(4318-4320)aTc>aCc	p.I1440T		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1440					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CGGCGGGGGGATGTCGCGCCC	0.677000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			7	28					0	0	1	0	0
BCAR3	8412	broad.mit.edu	37	1	94054885	94054885	+	Missense_Mutation	SNP	T	T	G			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr1:94054885T>G	ENST00000370244.1	-	7	866	c.578A>C	c.(577-579)aAg>aCg	p.K193T	BCAR3_ENST00000370243.1_Missense_Mutation_p.K193T|BCAR3_ENST00000260502.6_Missense_Mutation_p.K193T|BCAR3_ENST00000370247.3_Missense_Mutation_p.K102T	NM_001261408.1	NP_001248337.1	O75815	BCAR3_HUMAN	breast cancer anti-estrogen resistance 3	193	SH2.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	25		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		AGCGAGGTTCTTCCACTGACA	0.547000													4	52					0	0	1	0	0
PTCH2	8643	broad.mit.edu	37	1	45307636	45307636	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr1:45307636C>T	ENST00000447098.2	-	2	159	c.148G>A	c.(148-150)Ggg>Agg	p.G50R	PTCH2_ENST00000372192.3_Missense_Mutation_p.G50R	NM_001166292.1	NP_001159764.1	Q9Y6C5	PTC2_HUMAN	patched 2	50					protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					CTCTGGATCCCGCATCCCAGA	0.552000									Basal Cell Nevus syndrome				85	90					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32818263	32818263	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr13:32818263G>A	ENST00000380250.3	+	47	7268	c.6772G>A	c.(6772-6774)Gtt>Att	p.V2258I		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCTTTCTGTCGTTCCTGTCAA	0.473000													13	49					0	0	1	0	0
RAD21	5885	broad.mit.edu	37	8	117868410	117868410	+	Missense_Mutation	SNP	A	A	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr8:117868410A>T	ENST00000297338.2	-	8	1219	c.932T>A	c.(931-933)aTa>aAa	p.I311K		NM_006265.2	NP_006256.1	O60216	RAD21_HUMAN	RAD21 homolog (S. pombe)	311	Interaction with WAPAL and PDS5B.				apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|stomach(1)	32	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					CTTACCAGTTATATCAATAGG	0.388000													45	73					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36362814	36362814	+	Silent	SNP	C	C	T	rs148987065		TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr19:36362814C>T	ENST00000221891.4	+	6	918	c.726C>T	c.(724-726)gaC>gaT	p.D242D	APLP1_ENST00000586861.1_Silent_p.D236D|APLP1_ENST00000537454.2_Silent_p.D203D	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	242	Poly-Glu.				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGGCTGAGGACGAGGAAGAGG	0.637000													69	109					0	0	1	0	0
BBS10	79738	broad.mit.edu	37	12	76740974	76740974	+	Missense_Mutation	SNP	A	A	C			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr12:76740974A>C	ENST00000393262.3	-	2	874	c.791T>G	c.(790-792)aTt>aGt	p.I264S		NM_024685.3	NP_078961.3	Q8TAM1	BBS10_HUMAN	Bardet-Biedl syndrome 10	264					cellular protein metabolic process|nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	cilium	ATP binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)	19						AAGAGGCTGAATGGTTTCTGT	0.393000									Bardet-Biedl syndrome				5	34					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21083999	21083999	+	Splice_Site	SNP	C	C	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr22:21083999C>A	ENST00000255882.6	-	38	4495	c.4408_splice	c.e38-1	p.G1470_splice	PI4KA_ENST00000414196.3_Splice_Site_p.G222_splice|PI4KA_ENST00000572273.1_Splice_Site_p.G1412_splice	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	1412					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CTTAGACATGCCTAGGAGGAA	0.537000													4	6					4.096e-09	4.44312e-09	1	1	0
ZNF432	9668	broad.mit.edu	37	19	52537922	52537922	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr19:52537922C>A	ENST00000594154.1	-	5	1222	c.1010G>T	c.(1009-1011)cGa>cTa	p.R337L	ZNF432_ENST00000221315.5_Missense_Mutation_p.R337L			O94892	ZN432_HUMAN	zinc finger protein 432	337					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	29		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		TGTATGAGTTCGCTGATGTAT	0.408000													4	124					0.150653	0.150653	1	1	0
OR5AS1	219447	broad.mit.edu	37	11	55798207	55798207	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr11:55798207G>A	ENST00000313555.1	+	1	313	c.313G>A	c.(313-315)Gct>Act	p.A105T		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	105					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A105T(1)		endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					GTTTTTCTTCGCTTCTTTTGC	0.463000													16	35					0	0	1	0	0
CSPP1	79848	broad.mit.edu	37	8	68105709	68105709	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr8:68105709G>A	ENST00000262210.5	+	28	3357	c.3326G>A	c.(3325-3327)cGt>cAt	p.R1109H	CSPP1_ENST00000412460.1_Missense_Mutation_p.R764H|CSPP1_ENST00000521168.1_Intron|ARFGEF1_ENST00000520381.1_Intron	NM_024790.6	NP_079066.5	Q1MSJ5	CSPP1_HUMAN	centrosome and spindle pole associated protein 1	1144						centrosome|microtubule|spindle				NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|prostate(3)|skin(1)|urinary_tract(1)	49	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			GATAGCAGTCGTCCTAATGTA	0.403000													8	47					0	0	1	0	0
EXTL3	2137	broad.mit.edu	37	8	28573785	28573785	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr8:28573785G>A	ENST00000220562.4	+	3	1111	c.209G>A	c.(208-210)gGg>gAg	p.G70E	EXTL3_ENST00000523149.1_Intron|EXTL3_ENST00000519886.1_Intron	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	70						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		CCCCGGGTGGGGAACGAGCTG	0.597000													24	16					0	0	1	0	0
SOS1	6654	broad.mit.edu	37	2	39250208	39250208	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr2:39250208C>T	ENST00000426016.1	-	11	1447	c.1361G>A	c.(1360-1362)gGa>gAa	p.G454E	SOS1_ENST00000472480.1_5'UTR|SOS1_ENST00000395038.2_Missense_Mutation_p.G454E|SOS1_ENST00000402219.2_Missense_Mutation_p.G454E			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	454	PH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				ATGTTTGGCTCCTACACGTGT	0.393000									Noonan syndrome				49	59					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12726653	12726653	+	Silent	SNP	C	C	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr1:12726653C>T	ENST00000376221.1	+	4	1131	c.1131C>T	c.(1129-1131)caC>caT	p.H377H		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	377						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		ATGGTTTTCACGGATCCATTA	0.443000													34	75					0	0	1	0	0
GNAI1	2770	broad.mit.edu	37	7	79842101	79842101	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr7:79842101A>G	ENST00000351004.3	+	7	1163	c.790A>G	c.(790-792)Att>Gtt	p.I264V	GNAI1_ENST00000457358.2_Missense_Mutation_p.I212V	NM_002069.5	NP_002060.4	P63096	GNAI1_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	264					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody|nucleus	G-protein beta/gamma-subunit complex binding|GTP binding|metabotropic serotonin receptor binding|signal transducer activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	19						AGATACATCCATTATACTTTT	0.323000													39	45					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871043	170871043	+	Silent	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr6:170871043G>A	ENST00000392092.2	+	3	498	c.219G>A	c.(217-219)caG>caA	p.Q73Q	TBP_ENST00000540980.1_Silent_p.Q53Q|TBP_ENST00000230354.6_Silent_p.Q73Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	73	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q73Q(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcaacagcaacagcagc	0.562000													5	62					0	0	1	0	0
C7orf10	79783	broad.mit.edu	37	7	40900013	40900013	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr7:40900013T>C	ENST00000309930.5	+	15	1375	c.1351T>C	c.(1351-1353)Tac>Cac	p.Y451H	C7orf10_ENST00000401647.2_Missense_Mutation_p.Y377H|C7orf10_ENST00000464028.1_3'UTR|C7orf10_ENST00000335693.4_Missense_Mutation_p.Y425H	NM_001193311.1|NM_024728.2	NP_001180240.1|NP_079004.1	Q9HAC7	CG010_HUMAN	chromosome 7 open reading frame 10	425							transferase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)	18						GGTCCTGAGATACGATGACAG	0.572000													6	181					0	0	1	0	0
SPECC1L	23384	broad.mit.edu	37	22	24717686	24717686	+	Silent	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr22:24717686G>A	ENST00000314328.9	+	5	1023	c.738G>A	c.(736-738)ttG>ttA	p.L246L	SPECC1L_ENST00000416735.1_Intron|SPECC1L_ENST00000541492.1_Silent_p.L246L|KB-1896H10.1_ENST00000358654.2_Silent_p.L246L|SPECC1L_ENST00000437398.1_Silent_p.L246L	NM_001254733.1|NM_015330.3	NP_001241662.1|NP_056145.3	Q69YQ0	CYTSA_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1-like	246					cell cycle|cell division					breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(3)|stomach(2)|urinary_tract(1)	27						TATTGCAGTTGCAGGAACAGA	0.433000													39	145					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167675119	167675119	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr5:167675119C>T	ENST00000519204.1	+	26	6930	c.6812C>T	c.(6811-6813)aCg>aTg	p.T2271M	TENM2_ENST00000518659.1_Missense_Mutation_p.T2392M|TENM2_ENST00000403607.2_Missense_Mutation_p.T2216M|TENM2_ENST00000520394.1_Missense_Mutation_p.T2153M|TENM2_ENST00000545108.1_Missense_Mutation_p.T2391M					teneurin transmembrane protein 2																		CTGCAGTACACGGCCTATGGG	0.532000													4	203					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78208916	78208916	+	RNA	SNP	C	C	G	rs56290535	by1000genomes	TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr15:78208916C>G	ENST00000565869.1	+	0	53																											TCCAGATGTTCTCCTCCATCT	0.627000													5	110					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728670	20728670	+	Missense_Mutation	SNP	A	A	C			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr19:20728670A>C	ENST00000427401.4	-	4	433	c.339T>G	c.(337-339)ttT>ttG	p.F113L		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	113					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						AGCCCTTTTTAAACTGTAAAT	0.353000													4	120					0	0	1	0	0
SYNCRIP	10492	broad.mit.edu	37	6	86329033	86329033	+	Nonsense_Mutation	SNP	T	T	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr6:86329033T>A	ENST00000355238.6	-	9	1317	c.1111A>T	c.(1111-1113)Aaa>Taa	p.K371*	SYNCRIP_ENST00000369622.3_Nonsense_Mutation_p.K371*	NM_001159673.1|NM_001159674.1|NM_001159676.1|NM_001159677.1|NM_001253771.1	NP_001153145.1|NP_001153146.1|NP_001153148.1|NP_001153149.1|NP_001240700.1	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA interacting protein	371	RRM 3.				CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		GCATAATCTTTTAACTTCTTC	0.363000													5	97					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7680922	7680922	+	Nonsense_Mutation	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr17:7680922G>A	ENST00000572933.1	+	33	6677	c.5217G>A	c.(5215-5217)tgG>tgA	p.W1739*	DNAH2_ENST00000389173.2_Nonsense_Mutation_p.W1739*			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1739	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCTTTGACTGGCTCAGCCAAC	0.478000													5	422					0	0	1	0	0
PLEKHH3	79990	broad.mit.edu	37	17	40822621	40822621	+	Silent	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr17:40822621G>A	ENST00000293349.6	-	10	1945	c.1515C>T	c.(1513-1515)gaC>gaT	p.D505D	PLEKHH3_ENST00000412503.1_Silent_p.D505D|PLEKHH3_ENST00000456950.2_5'UTR|PLEKHH3_ENST00000591022.1_Silent_p.D508D			Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 3	508	FERM.				signal transduction	cytoskeleton				endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)|skin(2)	13		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		GTTCGTGACCGTCTGGGGACA	0.627000													5	88					0	0	1	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52723057	52723057	+	Silent	SNP	C	C	T	rs139139629	byFrequency	TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr19:52723057C>T	ENST00000322088.6	+	10	1300	c.1242C>T	c.(1240-1242)gaC>gaT	p.D414D	PPP2R1A_ENST00000462990.1_Silent_p.D235D|PPP2R1A_ENST00000444322.2_Silent_p.D359D	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	414	PP2A subunit C binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		TGGCTGAGGACGCCAAGTGGC	0.627000			Mis		clear cell ovarian carcinoma								23	46					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18023246	18023246	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr17:18023246G>A	ENST00000205890.5	+	2	1470	c.1132G>A	c.(1132-1134)Gtc>Atc	p.V378I		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	378	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					CCACTACACCGTCCCCTATGC	0.597000													47	99					0	0	1	0	0
GP1BA	2811	broad.mit.edu	37	17	4836806	4836806	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr17:4836806G>A	ENST00000329125.5	+	2	982	c.907G>A	c.(907-909)Gat>Aat	p.D303N		NM_000173.5	NP_000164.5	E7ES66	E7ES66_HUMAN	glycoprotein Ib (platelet), alpha polypeptide	303										central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(5)|stomach(1)|urinary_tract(1)	20						CACTGAGGGCGATAAGGTGCG	0.527000													10	168					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85699758	85699758	+	Silent	SNP	G	G	A	rs146868524		TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr4:85699758G>A	ENST00000322366.6	-	27	4823	c.4416C>T	c.(4414-4416)atC>atT	p.I1472I	WDFY3_ENST00000295888.4_Silent_p.I1472I			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1472						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTAGATGGAGGATGTGGCTGT	0.388000													29	43					0	0	1	0	0
EXTL3	2137	broad.mit.edu	37	8	28573786	28573786	+	Silent	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr8:28573786G>A	ENST00000220562.4	+	3	1112	c.210G>A	c.(208-210)ggG>ggA	p.G70G	EXTL3_ENST00000523149.1_Intron|EXTL3_ENST00000519886.1_Intron	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	70						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		CCCGGGTGGGGAACGAGCTGT	0.597000													24	16					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871082	170871082	+	Silent	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr6:170871082G>A	ENST00000392092.2	+	3	537	c.258G>A	c.(256-258)caG>caA	p.Q86Q	TBP_ENST00000540980.1_Silent_p.Q66Q|TBP_ENST00000230354.6_Silent_p.Q86Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	86	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q86Q(2)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.612000													5	66					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													3	15					6.4e-05	6.82667e-05	1	1	0
HOXD12	3238	broad.mit.edu	37	2	176965063	176965063	+	Silent	SNP	G	G	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr2:176965063G>A	ENST00000406506.2	+	1	606	c.534G>A	c.(532-534)gcG>gcA	p.A178A	HOXD12_ENST00000404162.2_Silent_p.A178A			P35452	HXD12_HUMAN	homeobox D12	178						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(1)|lung(7)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)		CAGTGCAGGCGGCGGGCGTTG	0.687000													12	25					0	0	1	0	0
GEMIN5	25929	broad.mit.edu	37	5	154270986	154270986	+	Silent	SNP	G	G	C			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr5:154270986G>C	ENST00000285873.7	-	26	4152	c.4077C>G	c.(4075-4077)ctC>ctG	p.L1359L		NM_001252156.1|NM_015465.4	NP_001239085.1|NP_056280.2	Q8TEQ6	GEMI5_HUMAN	gem (nuclear organelle) associated protein 5	1359					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding	p.L1359L(1)		breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTTCTGAAAAGAGCTCCTTAA	0.468000													8	158					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20389698	20389698	+	Silent	SNP	T	T	A			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr14:20389698T>A	ENST00000315915.4	+	1	958	c.933T>A	c.(931-933)atT>atA	p.I311I		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CAAGGAGAATTTCTGAAATGT	0.368000													36	44					0	0	1	0	0
AC073321.4	0	broad.mit.edu	37	2	217475032	217475032	+	RNA	DEL	A	A	-	rs71401156		TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr2:217475032delA	ENST00000441803.1	+	0	195																											ATTTTATTTCAAAAAAAAAAA	0.373													3	5	---	---	---	---					
TRERF1	55809	broad.mit.edu	37	6	42204105	42204106	+	In_Frame_Ins	INS	-	-	TCC	rs146190272	by1000genomes	TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr6:42204105_42204106insTCC	ENST00000541110.1	-	16	3531_3532	c.2963_2964insGGA	c.(2962-2964)gcc>gGGAcc	p.988_988A>GT	TRERF1_ENST00000372917.4_In_Frame_Ins_p.885_885A>GT|TRERF1_ENST00000354325.2_In_Frame_Ins_p.885_885A>GT|TRERF1_ENST00000372922.4_In_Frame_Ins_p.968_968A>GT|TRERF1_ENST00000340840.2_In_Frame_Ins_p.885_885A>GT			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	968	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTTCTTCCGGGtcctcctcctc	0.530													4	4	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20086381	20086382	+	RNA	INS	-	-	T			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr14:20086381_20086382insT	ENST00000548261.1	+	0	135																											GTCTTACAAGGTAAAAAAAATG	0.312													4	9	---	---	---	---					
PCNX	22990	broad.mit.edu	37	14	71445025	71445026	+	Frame_Shift_Del	DEL	AC	AC	-	rs142489415	by1000genomes	TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr14:71445025_71445026delAC	ENST00000304743.2	+	6	2417_2418	c.1971_1972delAC	c.(1969-1974)gaacfs	p.EH657fs	PCNX_ENST00000439984.3_Frame_Shift_Del_p.EH657fs|PCNX_ENST00000238570.5_Frame_Shift_Del_p.EH657fs	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	657						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		CAGACTCTGAACACACACACAA	0.485													7	216	---	---	---	---					
TMEM121	80757	broad.mit.edu	37	14	105996050	105996052	+	In_Frame_Del	DEL	GCC	GCC	-	rs5811180		TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr14:105996050_105996052delGCC	ENST00000392519.2	+	2	1043_1045	c.879_881delGCC	c.(877-882)gtg>gt	p.VP293del	TMEM121_ENST00000431372.1_In_Frame_Del_p.VP293del	NM_025268.2	NP_079544.1	Q9BTD3	TM121_HUMAN	transmembrane protein 121	293	Pro-rich.					integral to membrane				endometrium(2)|lung(1)	3		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0188)	Epithelial(152;0.0959)|all cancers(159;0.235)		GCAACTCGGTgccgccgccgccg	0.768													5	6	---	---	---	---					
ARNT2	9915	broad.mit.edu	37	15	80873662	80873662	+	Frame_Shift_Del	DEL	C	C	-			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr15:80873662delC	ENST00000533983.1	+	18	2141	c.1802delC	c.(1801-1803)tcfs	p.S601fs	ARNT2_ENST00000527771.1_Frame_Shift_Del_p.S601fs|ARNT2_ENST00000303329.4_Frame_Shift_Del_p.S612fs			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	612					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			GACCCCTCTTCCTACAGCCCC	0.572													19	84	---	---	---	---					
FLT3LG	0	broad.mit.edu	37	19	49982166	49982166	+	Splice_Site	DEL	C	C	-			TCGA-KK-A6E4-01A-11D-A30E-08	TCGA-KK-A6E4-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	40596942-42c7-4514-8bf8-a5290015cfd8	03842b93-be03-4e34-a1c4-c29aa2f3a1ec	g.chr19:49982166delC	ENST00000595510.1	+	5	398	c.96_splice	c.e5-1	p.P35_splice	FLT3LG_ENST00000596435.1_Intron|FLT3LG_ENST00000204637.2_Splice_Site_p.P35_splice|FLT3LG_ENST00000594009.1_Splice_Site_p.P117_splice|FLT3LG_ENST00000595815.1_3'UTR|CTD-3148I10.9_ENST00000599536.1_Intron|FLT3LG_ENST00000597551.1_Splice_Site_p.P117_splice|FLT3LG_ENST00000600429.1_Splice_Site_p.P117_splice|FLT3LG_ENST00000344019.3_Splice_Site_p.P117_splice			P49771	FLT3L_HUMAN	fms-related tyrosine kinase 3 ligand	117					positive regulation of cell proliferation|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity	p.S118fs*24(1)		large_intestine(2)|lung(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	10		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00154)|GBM - Glioblastoma multiforme(486;0.0246)		CTGCTCCCAGCCCCCCCCCAG	0.687													3	3	---	---	---	---