Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PRICKLE2	166336	broad.mit.edu	37	3	64085137	64085137	+	Missense_Mutation	SNP	A	A	C			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr3:64085137A>C	ENST00000295902.6	-	8	2710	c.2125T>G	c.(2125-2127)Tcc>Gcc	p.S709A	PRICKLE2_ENST00000564377.1_Missense_Mutation_p.S765A|RP11-129B22.1_ENST00000482609.1_RNA|PRICKLE2-AS1_ENST00000476308.1_RNA	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	709	Arg-rich.					cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		TTTAACCGGGAGATGGCCTCG	0.637000													15	33					0	0	1	0	0
RABL6	55684	broad.mit.edu	37	9	139726231	139726231	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr9:139726231G>A	ENST00000371675.3	+	6	1057	c.172G>A	c.(172-174)Gtg>Atg	p.V58M	RABL6_ENST00000357466.2_Missense_Mutation_p.V173M|RABL6_ENST00000371663.4_Missense_Mutation_p.V173M|RABL6_ENST00000466096.1_3'UTR|RABL6_ENST00000432842.2_Missense_Mutation_p.V135M|RABL6_ENST00000371671.4_Missense_Mutation_p.V173M|RABL6_ENST00000311502.7_Missense_Mutation_p.V173M					RAB, member RAS oncogene family-like 6																		GCCAGTGTGCGTGCTGGGAAA	0.607000													18	29					0	0	1	0	0
ADCYAP1	116	broad.mit.edu	37	18	908301	908301	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr18:908301G>A	ENST00000579794.1	+	3	556	c.278G>A	c.(277-279)cGc>cAc	p.R93H	ADCYAP1_ENST00000450565.3_Missense_Mutation_p.R93H	NM_001117.3	NP_001108.2	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary)	93					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding			endometrium(1)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	12						GAGGCCTACCGCAAAGTGCTG	0.647000													3	24					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207175936	207175936	+	Silent	SNP	G	G	A			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr2:207175936G>A	ENST00000374423.3	+	5	7070	c.6684G>A	c.(6682-6684)tcG>tcA	p.S2228S		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2228							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						AGTATATTTCGAAATACTCTG	0.363000													8	20					0	0	1	0	0
FBXL17	64839	broad.mit.edu	37	5	107356650	107356650	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr5:107356650C>T	ENST00000542267.1	-	7	2204	c.1798G>A	c.(1798-1800)Gtg>Atg	p.V600M	FBXL17_ENST00000496714.1_Missense_Mutation_p.V202M|FBXL17_ENST00000359660.5_Missense_Mutation_p.V202M	NM_001163315.2	NP_001156787.2	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	600										endometrium(1)|large_intestine(4)|lung(1)	6		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		TTACAGGACACCAAATATAGC	0.313000													10	29					0	0	1	0	0
TGFB2	7042	broad.mit.edu	37	1	218607454	218607454	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr1:218607454A>G	ENST00000366929.4	+	4	1092	c.625A>G	c.(625-627)Acc>Gcc	p.T209A	TGFB2_ENST00000366930.4_Missense_Mutation_p.T181A	NM_001135599.2	NP_001129071.1	P61812	TGFB2_HUMAN	transforming growth factor, beta 2	181					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding			breast(1)|endometrium(1)|large_intestine(11)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(1)	31				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		AACATCTCCAACCCAGCGCTA	0.433000													5	109					0	0	1	0	0
GFI1B	8328	broad.mit.edu	37	9	135866331	135866331	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr9:135866331G>A	ENST00000339463.3	+	11	1706	c.887G>A	c.(886-888)cGc>cAc	p.R296H	GFI1B_ENST00000372123.1_Missense_Mutation_p.R250H|GFI1B_ENST00000450530.1_Missense_Mutation_p.R296H|GFI1B_ENST00000372122.1_Missense_Mutation_p.R296H|GFI1B_ENST00000534944.1_Missense_Mutation_p.R250H|GFI1B_ENST00000372124.1_Missense_Mutation_p.R250H			Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription repressor	296	Interaction with ARIH2.|Mediates interaction with GATA1.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		ACCCACAGCCGCAAGCACACA	0.627000													11	33					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107288538	107288538	+	Missense_Mutation	SNP	T	T	A			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr9:107288538T>A	ENST00000277216.3	-	1	952	c.953A>T	c.(952-954)cAg>cTg	p.Q318L		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	318					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						TTGATCTTACTGGTTAATAGC	0.373000													33	70					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249535	52249535	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr19:52249535C>T	ENST00000595042.1	-	3	854	c.713G>A	c.(712-714)cGt>cAt	p.R238H	FPR1_ENST00000304748.4_Missense_Mutation_p.R238H	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	238				R -> P (in Ref. 1; AAA36362).	activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CCGTAAGGGACGACTGGACTT	0.517000													9	28					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129913572	129913572	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr10:129913572T>C	ENST00000368654.3	-	7	1475	c.1100A>G	c.(1099-1101)tAt>tGt	p.Y367C	MKI67_ENST00000368653.3_Intron	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	367					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				ACCAGTAGTATACAGGTCTTT	0.418000													46	83					0	0	1	0	0
KIRREL	55243	broad.mit.edu	37	1	158064789	158064789	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr1:158064789G>A	ENST00000368172.1	+	11	1607	c.1595G>A	c.(1594-1596)cGg>cAg	p.R532Q	KIRREL_ENST00000368173.3_Missense_Mutation_p.R734Q|KIRREL_ENST00000360089.4_Missense_Mutation_p.R554Q|KIRREL_ENST00000392272.2_Missense_Mutation_p.R615Q|KIRREL_ENST00000359209.6_Missense_Mutation_p.R718Q|KIRREL_ENST00000416935.2_Missense_Mutation_p.R618Q			Q96J84	KIRR1_HUMAN	kin of IRRE like (Drosophila)	718						integral to membrane		p.R554Q(1)|p.R734Q(1)		NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(5)|skin(3)|stomach(1)	38	all_hematologic(112;0.0378)					GGCCTGGAGCGGACCCCATAT	0.617000													4	13					0	0	1	0	0
SERPINB8	5271	broad.mit.edu	37	18	61654457	61654457	+	Missense_Mutation	SNP	T	T	G			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr18:61654457T>G	ENST00000397985.2	+	7	1326	c.1070T>G	c.(1069-1071)aTc>aGc	p.I357S	SERPINB8_ENST00000493661.1_Intron|SERPINB8_ENST00000353706.2_Missense_Mutation_p.I357S|SERPINB8_ENST00000542677.1_Missense_Mutation_p.I175S	NM_001276490.1	NP_001263419.1	P50452	SPB8_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 8	357					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	17		Esophageal squamous(42;0.129)				CTTTTCTTCATCAGGCACCAC	0.507000													38	38					0	0	1	0	0
ZSCAN21	7589	broad.mit.edu	37	7	99661891	99661891	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr7:99661891C>T	ENST00000292450.4	+	4	1237	c.1073C>T	c.(1072-1074)gCg>gTg	p.A358V	ZSCAN21_ENST00000543588.1_Missense_Mutation_p.R324C|ZNF3_ENST00000413658.2_3'UTR|ZSCAN21_ENST00000456748.2_Missense_Mutation_p.R324C	NM_145914.2	NP_666019.1	Q9Y5A6	ZSC21_HUMAN	zinc finger and SCAN domain containing 21	358					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|skin(1)	21	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			ACAGAAGAGGCGCCATATCAG	0.498000													25	26					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35763243	35763243	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr3:35763243C>T	ENST00000187397.4	+	14	1598	c.1142C>T	c.(1141-1143)aCg>aTg	p.T381M	ARPP21_ENST00000458225.1_Missense_Mutation_p.T347M|ARPP21_ENST00000444190.1_Missense_Mutation_p.T327M|ARPP21_ENST00000417925.1_Missense_Mutation_p.T347M|ARPP21_ENST00000337271.5_Missense_Mutation_p.T327M	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	381	Ser-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						ATGACCAAGACGGCGAGTTTT	0.542000													12	24					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179489271	179489271	+	Missense_Mutation	SNP	A	A	T			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr2:179489271A>T	ENST00000589042.1	-	242	44960	c.44736T>A	c.(44734-44736)caT>caA	p.H14912Q	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.H5972Q|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.H12344Q|TTN_ENST00000342175.6_Missense_Mutation_p.H6039Q|TTN_ENST00000460472.2_Missense_Mutation_p.H5847Q|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.H13271Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13271	Fibronectin type-III 8.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGTACAGTCATGTATAACAA	0.368000													24	49					0	0	1	0	0
ANKRD30BL	554226	broad.mit.edu	37	2	132905792	132905792	+	Missense_Mutation	SNP	G	G	C	rs143919579	by1000genomes	TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr2:132905792G>C	ENST00000409867.1	-	6	938	c.689C>G	c.(688-690)tCt>tGt	p.S230C	ANKRD30BL_ENST00000470729.1_5'UTR					ankyrin repeat domain 30B-like									p.S230C(2)		endometrium(1)|kidney(3)	4						TGTTCCTTCAGATGTTCCTTC	0.443000													3	13					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32633777	32633777	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr9:32633777C>T	ENST00000242310.4	-	1	1890	c.1801G>A	c.(1801-1803)Ggc>Agc	p.G601S	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	601					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CCAAAGGTGCCCCGAAGACCC	0.488000													6	151					0	0	1	0	0
TIMM22	29928	broad.mit.edu	37	17	900393	900393	+	Missense_Mutation	SNP	C	C	G			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr17:900393C>G	ENST00000327158.3	+	1	37	c.11C>G	c.(10-12)gCc>gGc	p.A4G		NM_013337.2	NP_037469.2	Q9Y584	TIM22_HUMAN	translocase of inner mitochondrial membrane 22 homolog (yeast)	4					transmembrane transport	integral to membrane|mitochondrial inner membrane	protein transporter activity			breast(2)|endometrium(2)|large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)	7				UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		ATGGCGGCGGCCGCCCCCAAT	0.667000													8	8					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108211370	108211370	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr3:108211370A>G	ENST00000273353.3	-	10	964	c.908T>C	c.(907-909)cTa>cCa	p.L303P		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	303	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TTGTCCAGATAGAATTTGATA	0.368000													16	9					0	0	1	0	0
MAMLD1	10046	broad.mit.edu	37	X	149639651	149639651	+	Silent	SNP	A	A	G			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chrX:149639651A>G	ENST00000370401.2	+	4	2116	c.1806A>G	c.(1804-1806)caA>caG	p.Q602Q	MAMLD1_ENST00000432680.2_Silent_p.Q577Q|MAMLD1_ENST00000455522.2_Silent_p.Q83Q|MAMLD1_ENST00000426613.2_Silent_p.Q577Q|MAMLD1_ENST00000262858.5_Silent_p.Q602Q			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	602	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					agcagcagcaacagcagcagc	0.602000													3	47					0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57957910	57957910	+	Missense_Mutation	SNP	A	A	T			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr12:57957910A>T	ENST00000455537.2	+	4	585	c.311A>T	c.(310-312)cAg>cTg	p.Q104L	KIF5A_ENST00000286452.5_Intron	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	104	Kinesin-motor.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						CACGACCCTCAGCTGATGGGA	0.512000													11	32					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120474795	120474795	+	Missense_Mutation	SNP	A	A	C			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr9:120474795A>C	ENST00000355622.6	+	3	490	c.389A>C	c.(388-390)aAg>aCg	p.K130T	TLR4_ENST00000394487.4_Missense_Mutation_p.K90T|TLR4_ENST00000472304.1_3'UTR	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	130					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						AGTTTACAGAAGCTGGTGGCT	0.438000													20	55					0	0	1	0	0
SPOP	8405	broad.mit.edu	37	17	47696426	47696426	+	Missense_Mutation	SNP	A	A	C			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr17:47696426A>C	ENST00000393331.3	-	7	867	c.397T>G	c.(397-399)Ttc>Gtc	p.F133V	SPOP_ENST00000347630.2_Missense_Mutation_p.F133V|SPOP_ENST00000503676.1_Missense_Mutation_p.F133V|SPOP_ENST00000504102.1_Missense_Mutation_p.F133V|SPOP_ENST00000393328.2_Missense_Mutation_p.F133V	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	133	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding	p.F133V(4)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						AATTTCTTGAATCCCCAGTCT	0.448000										Prostate(2;0.17)			38	70					0	0	1	0	0
ABCD3	5825	broad.mit.edu	37	1	94946040	94946040	+	Silent	SNP	C	C	A			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr1:94946040C>A	ENST00000370214.4	+	9	729	c.705C>A	c.(703-705)gcC>gcA	p.A235A	ABCD3_ENST00000454898.2_Silent_p.A259A|ABCD3_ENST00000536817.1_Silent_p.A162A|ABCD3_ENST00000394233.2_Silent_p.A235A	NM_002858.3	NP_002849.1	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D (ALD), member 3	235	ABC transmembrane type-1.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(2)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		GCATGATGGCCTACTTGGTTG	0.363000													31	52					8.4185e-14	8.77674e-14	1	1	0
ZNF208	7757	broad.mit.edu	37	19	22154452	22154452	+	Silent	SNP	A	A	G			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr19:22154452A>G	ENST00000397126.4	-	4	3532	c.3384T>C	c.(3382-3384)ctT>ctC	p.L1128L	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208									p.L1000L(2)|p.L1128L(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TATGTTTAGTAAGGATTGAGA	0.373000													3	58					0	0	1	0	0
ASAP2	8853	broad.mit.edu	37	2	9475308	9475308	+	Splice_Site	SNP	G	G	C			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr2:9475308G>C	ENST00000281419.3	+	9	1189	c.849_splice	c.e9+1	p.E283_splice	ASAP2_ENST00000315273.4_Splice_Site_p.E283_splice	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	283					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						AACAGAAAGAGGTGAGGGGAT	0.413000													5	43					0	0	1	0	0
PCDHA13	0	broad.mit.edu	37	5	140263149	140263149	+	Silent	SNP	G	G	A			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr5:140263149G>A	ENST00000289272.2	+	1	1296	c.1296G>A	c.(1294-1296)tcG>tcA	p.S432S	PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA13_ENST00000409494.1_Silent_p.S432S|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGGGGGCTCGCCTTCGCTGT	0.657000													5	137					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14513675	14513675	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr18:14513675T>C	ENST00000358970.5	-	10	1518	c.1519A>G	c.(1519-1521)Aaa>Gaa	p.K507E		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	507								p.K507E(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GAATTCATTTTCTTTTCAGCC	0.284000													4	108					0	0	1	0	0
EMILIN1	11117	broad.mit.edu	37	2	27305360	27305360	+	Silent	SNP	C	C	T			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr2:27305360C>T	ENST00000380320.4	+	4	1420	c.921C>T	c.(919-921)gcC>gcT	p.A307A		NM_007046.3	NP_008977.1	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1	307					cell adhesion	collagen				breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(1)|lung(14)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	26	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTGCCTGGCCGGGCTAGATG	0.721000													4	3					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134073250	134073250	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr4:134073250G>A	ENST00000264360.4	+	1	2781	c.1955G>A	c.(1954-1956)cGg>cAg	p.R652Q		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	652	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		GACCCCCAGCGGCCTTATGAG	0.677000													6	11					0	0	1	0	0
DCXR	51181	broad.mit.edu	37	17	79995534	79995534	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr17:79995534G>A	ENST00000306869.2	-	1	74	c.25C>T	c.(25-27)Cgg>Tgg	p.R9W		NM_001195218.1|NM_016286.3	NP_001182147.1|NP_057370.1	Q7Z4W1	DCXR_HUMAN	dicarbonyl/L-xylulose reductase	9					D-xylose metabolic process|glucose metabolic process|protein homotetramerization|xylulose metabolic process	membrane	binding|L-xylulose reductase (NADP+) activity			kidney(1)|lung(3)	4	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			ACCAGCACCCGGCGGCCCGCG	0.746000													4	8					0	0	1	0	0
RPL29	6159	broad.mit.edu	37	3	52027888	52027888	+	Silent	SNP	G	G	A			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr3:52027888G>A	ENST00000466397.1	-	4	497	c.357C>T	c.(355-357)tgC>tgT	p.C119C	RPL29_ENST00000479017.1_Silent_p.C119C|RPL29_ENST00000475248.1_Silent_p.C119C|RPL29_ENST00000294189.6_Silent_p.C119C|RPL29_ENST00000495383.1_Silent_p.C119C			P47914	RL29_HUMAN	ribosomal protein L29	119					embryo implantation|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	heparin binding|protein binding|RNA binding|structural constituent of ribosome			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		cctttggccGGCACAGCCTGA	0.622000													3	37					0	0	1	0	0
FLOT1	10211	broad.mit.edu	37	6	30708568	30708568	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr6:30708568T>C	ENST00000376389.3	-	6	582	c.362A>G	c.(361-363)tAt>tGt	p.Y121C	FLOT1_ENST00000470643.1_5'UTR|FLOT1_ENST00000456573.2_Missense_Mutation_p.Y73C	NM_005803.2	NP_005794.1	O75955	FLOT1_HUMAN	flotillin 1	121						centriolar satellite|endosome|integral to membrane|melanosome|membrane fraction				breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|prostate(1)	13						CCTGTCCTTATAGATCTCCTG	0.438000													5	57					0	0	1	0	0
NEO1	4756	broad.mit.edu	37	15	73528785	73528785	+	Silent	SNP	A	A	C			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr15:73528785A>C	ENST00000339362.5	+	9	1836	c.1389A>C	c.(1387-1389)gcA>gcC	p.A463A	NEO1_ENST00000560262.1_Silent_p.A463A|NEO1_ENST00000261908.6_Silent_p.A463A|NEO1_ENST00000560352.1_3'UTR|NEO1_ENST00000558964.1_Silent_p.A463A			Q92859	NEO1_HUMAN	neogenin 1	463	Fibronectin type-III 1.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						GGACACCTGCATCAGATCCTC	0.562000													39	68					0	0	1	0	0
UBB	7314	broad.mit.edu	37	17	16285491	16285491	+	Silent	SNP	C	C	T	rs16962973		TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr17:16285491C>T	ENST00000302182.3	+	2	662	c.270C>T	c.(268-270)acC>acT	p.T90T	UBB_ENST00000395837.1_Silent_p.T90T|RP11-138I1.4_ENST00000583934.1_RNA|UBB_ENST00000395839.1_Silent_p.T90T|UBB_ENST00000578649.1_Intron|UBB_ENST00000535788.1_Intron	NM_018955.2	NP_061828.1	P0CG47	UBB_HUMAN	ubiquitin B	90	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AGACCATCACCCTGGAAGTGG	0.552000													4	80					0	0	1	0	0
CLIC6	54102	broad.mit.edu	37	21	36043027	36043027	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr21:36043027T>C	ENST00000360731.3	+	1	1340	c.1340T>C	c.(1339-1341)cTg>cCg	p.L447P	CLIC6_ENST00000349499.2_Missense_Mutation_p.L447P			Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	447						chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19						CCCCGGGCCCTGGGGCAGGAG	0.667000													9	9					0	0	1	0	0
RFX6	222546	broad.mit.edu	37	6	117241512	117241512	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr6:117241512T>C	ENST00000332958.2	+	12	1238	c.1222T>C	c.(1222-1224)Tct>Cct	p.S408P		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	408					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						TGTCGTTAATTCTATGGTGTC	0.398000													8	80					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93090147	93090147	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr7:93090147C>T	ENST00000359558.2	-	10	1035	c.736G>A	c.(736-738)Gtg>Atg	p.V246M	CALCR_ENST00000394441.1_Missense_Mutation_p.V212M|CALCR_ENST00000360249.4_Missense_Mutation_p.V228M|CALCR_ENST00000421592.1_Missense_Mutation_p.V228M|CALCR_ENST00000426151.1_Missense_Mutation_p.V212M	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	228					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	TCCCTTCGCACGAGCTCTCCA	0.383000													39	68					0	0	1	0	0
TMEFF2	23671	broad.mit.edu	37	2	192863838	192863838	+	Silent	SNP	T	T	C			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr2:192863838T>C	ENST00000392314.1	-	6	1024	c.633A>G	c.(631-633)gcA>gcG	p.A211A	AC098617.1_ENST00000424116.2_RNA|TMEFF2_ENST00000487771.1_5'UTR|AC098617.1_ENST00000428980.2_RNA|TMEFF2_ENST00000272771.5_Silent_p.A211A			Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two follistatin-like domains 2	211	Kazal-like 2.					extracellular region|integral to membrane				breast(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(12)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			TCTGACACGATGCTTCTTTGA	0.368000													28	47					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72338097	72338097	+	Missense_Mutation	SNP	G	G	C			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr15:72338097G>C	ENST00000356056.5	-	2	1280	c.808C>G	c.(808-810)Cag>Gag	p.Q270E	MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000566885.1_Intron|MYO9A_ENST00000444904.1_Missense_Mutation_p.Q270E|MYO9A_ENST00000424560.1_Missense_Mutation_p.Q270E|MYO9A_ENST00000564571.1_Missense_Mutation_p.Q270E	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	270	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						AGAATAATCTGTTCTACTCCA	0.388000													17	29					0	0	1	0	0
ATAD5	79915	broad.mit.edu	37	17	29196386	29196386	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr17:29196386G>A	ENST00000321990.4	+	13	3812	c.3434G>A	c.(3433-3435)tGt>tAt	p.C1145Y		NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1145					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GTGTATGCTTGTGCCCAGGAG	0.398000													6	85					0	0	1	0	0
YWHAZ	7534	broad.mit.edu	37	8	101960982	101960982	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr8:101960982C>A	ENST00000395957.2	-	3	477	c.136G>T	c.(136-138)Gtt>Ttt	p.V46F	YWHAZ_ENST00000419477.2_Missense_Mutation_p.V46F|YWHAZ_ENST00000395951.3_Missense_Mutation_p.V46F|YWHAZ_ENST00000395953.2_Missense_Mutation_p.V46F|YWHAZ_ENST00000395956.3_Missense_Mutation_p.V46F|YWHAZ_ENST00000395958.2_Missense_Mutation_p.V46F|YWHAZ_ENST00000395948.2_Intron|YWHAZ_ENST00000353245.3_Missense_Mutation_p.V46F|YWHAZ_ENST00000521309.1_Intron|YWHAZ_ENST00000457309.1_Missense_Mutation_p.V46F			P63104	1433Z_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	46					anti-apoptosis|mRNA metabolic process|platelet activation|signal transduction	cytosol|melanosome	transcription factor binding			large_intestine(1)|lung(2)	3	all_cancers(14;7.43e-06)|all_epithelial(15;2.77e-08)|Lung NSC(17;6.08e-05)|all_lung(17;0.000197)		Epithelial(11;2.79e-11)|all cancers(13;5.45e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.75e-05)		Ginkgo biloba(DB01381)	TTATAAGCAACTGAGAGAAGA	0.473000													4	91					0.00909568	0.00909568	1	1	0
FSIP2	401024	broad.mit.edu	37	2	186678578	186678578	+	Missense_Mutation	SNP	T	T	A			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr2:186678578T>A	ENST00000343098.5	+	18	20401	c.20401T>A	c.(20401-20403)Ttt>Att	p.F6801I	FSIP2_ENST00000424728.1_Missense_Mutation_p.F6712I	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						CCTGAAAAAATTTTTGTCACT	0.373000													27	36					0	0	1	0	0
MESP2	145873	broad.mit.edu	37	15	90320121	90320144	+	In_Frame_Del	DEL	AGGGGCAGGGGCAAGGGCAGGGGC	AGGGGCAGGGGCAAGGGCAGGGGC	-	rs56192595		TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr15:90320121_90320144delAGGGGCAGGGGCAAGGGCAGGGGC	ENST00000341735.3	+	1	533_556	c.533_556delAGGGGCAGGGGCAAGGGCAGGGGC	c.(532-558)gag>g	p.EGQGQGQGQ178del	MESP2_ENST00000558723.1_Intron|MESP2_ENST00000560219.1_Intron	NM_001039958.1	NP_001035047.1	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog (mouse)	178					Notch signaling pathway	nucleus	DNA binding	p.Q198_G205delQGQGQGQG(1)		kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			ACGCaggcggaggggcaggggcaagggcaggggcaggggcaggg	0.777													4	2	---	---	---	---					
ERN1	2081	broad.mit.edu	37	17	62207360	62207362	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-KK-A7AQ-01A-11D-A33T-08	TCGA-KK-A7AQ-11A-11D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b5232ee2-18b3-4257-8a61-5d460b11ee7e	fc1ad195-6261-4275-bed6-8d52f2622b1a	g.chr17:62207360_62207362delCAG	ENST00000433197.2	-	1	123_125	c.28_30delCTG	c.(28-30)del	p.L10del	ERN1_ENST00000606895.1_In_Frame_Del_p.L10del	NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	10					activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						gcagcagcgtcagcagcagcagc	0.793													2	4	---	---	---	---