Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DOCK10	55619	broad.mit.edu	37	2	225652092	225652092	+	Missense_Mutation	SNP	T	T	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr2:225652092T>A	ENST00000409592.3	-	49	5536	c.5423A>T	c.(5422-5424)tAc>tTc	p.Y1808F	DOCK10_ENST00000258390.7_Missense_Mutation_p.Y1814F			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1814	DHR-2.						GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CACACACATGTATAGCTGCTC	0.423000													57	145					0	0	1	0	0
SLC41A1	254428	broad.mit.edu	37	1	205768182	205768182	+	Silent	SNP	G	G	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr1:205768182G>T	ENST00000367137.3	-	5	1614	c.600C>A	c.(598-600)gtC>gtA	p.V200V	SLC41A1_ENST00000468057.1_5'UTR	NM_173854.4	NP_776253.3	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 (magnesium transporter), member 1	200						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	17	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			TCCAGCCAAAGACGACGGCTG	0.607000													19	55					4.35082e-09	4.64366e-09	1	1	0
ZEB1	6935	broad.mit.edu	37	10	31809478	31809478	+	Missense_Mutation	SNP	A	A	G			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr10:31809478A>G	ENST00000446923.2	+	7	1558	c.1167A>G	c.(1165-1167)atA>atG	p.I389M	ZEB1_ENST00000320985.10_Missense_Mutation_p.I405M|ZEB1_ENST00000542815.3_Missense_Mutation_p.I338M|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000560721.2_Missense_Mutation_p.I385M|ZEB1_ENST00000361642.5_Missense_Mutation_p.I406M	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	405					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				TGTCTCCCATAAGTATCAATT	0.438000													20	53					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219888790	219888790	+	Missense_Mutation	SNP	A	A	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr2:219888790A>T	ENST00000341552.5	-	15	2625	c.2542T>A	c.(2542-2544)Tgg>Agg	p.W848R	CCDC108_ENST00000453220.1_Missense_Mutation_p.W848R|CCDC108_ENST00000441968.1_Missense_Mutation_p.W848R	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	848						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGCTGCTTCCAGGAGCTGCCC	0.602000													27	82					0	0	1	0	0
ZNF470	388566	broad.mit.edu	37	19	57089490	57089490	+	Missense_Mutation	SNP	T	T	G			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr19:57089490T>G	ENST00000330619.8	+	6	2379	c.1693T>G	c.(1693-1695)Tac>Gac	p.Y565D	ZNF470_ENST00000391709.3_Missense_Mutation_p.Y565D|ZNF470_ENST00000601902.1_Intron	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	565					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		TGAGAAGCCTTACGAATGTAT	0.443000													17	53					0	0	1	0	0
GPR107	0	broad.mit.edu	37	9	132854651	132854651	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr9:132854651G>A	ENST00000372406.1	+	9	1361	c.854G>A	c.(853-855)cGa>cAa	p.R285Q	GPR107_ENST00000372410.3_Missense_Mutation_p.R285Q|GPR107_ENST00000347136.6_Missense_Mutation_p.R285Q	NM_001136557.1	NP_001130029.1	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107	285						integral to membrane				endometrium(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	11		Ovarian(14;0.000531)				CATATCCTTCGAAAACGACGG	0.423000													5	84					0	0	1	0	0
DIAPH1	1729	broad.mit.edu	37	5	140963116	140963116	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr5:140963116G>A	ENST00000253811.6	-	5	609	c.469C>T	c.(469-471)Cgg>Tgg	p.R157W	DIAPH1_ENST00000518047.1_Missense_Mutation_p.R148W|DIAPH1_ENST00000398557.4_Missense_Mutation_p.R157W|DIAPH1_ENST00000398562.2_Missense_Mutation_p.R148W|DIAPH1_ENST00000398566.3_Missense_Mutation_p.R148W|DIAPH1_ENST00000389054.3_Missense_Mutation_p.R157W|DIAPH1_ENST00000389057.5_Missense_Mutation_p.R148W|DIAPH1_ENST00000520569.1_Missense_Mutation_p.R103W			O60610	DIAP1_HUMAN	diaphanous-related formin 1	157	GBD/FH3.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(12)|pancreas(1)|skin(2)|stomach(2)	23			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCATATCCCGCAAGCCTGAC	0.512000													4	131					0	0	1	0	0
NCF2	4688	broad.mit.edu	37	1	183539961	183539961	+	Missense_Mutation	SNP	A	A	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr1:183539961A>T	ENST00000413720.1	-	5	762	c.488T>A	c.(487-489)gTg>gAg	p.V163E	NCF2_ENST00000418089.1_Missense_Mutation_p.V127E|NCF2_ENST00000367536.1_Missense_Mutation_p.V208E|NCF2_ENST00000367535.3_Missense_Mutation_p.V208E	NM_001190794.1	NP_001177723.1	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	208					cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30						TTGATCCACCACAGATGCCAC	0.532000													21	41					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155200544	155200544	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr3:155200544T>C	ENST00000460012.1	-	23	3538	c.3181A>G	c.(3181-3183)Aca>Gca	p.T1061A	PLCH1_ENST00000340059.7_Missense_Mutation_p.T1099A|PLCH1_ENST00000334686.6_Missense_Mutation_p.T1061A|PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000494598.1_Intron|PLCH1_ENST00000414191.1_Missense_Mutation_p.T1061A			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1099					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			AGATCTTGTGTGGGGTTAACT	0.478000													46	134					0	0	1	0	0
SMIM11	54065	broad.mit.edu	37	21	35757886	35757886	+	Silent	SNP	A	A	G			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr21:35757886A>G	ENST00000399295.2	+	3	493	c.123A>G	c.(121-123)aaA>aaG	p.K41K	SMIM11_ENST00000399292.3_Silent_p.K41K|SMIM11_ENST00000481710.1_3'UTR|SMIM11_ENST00000399299.1_Intron					small integral membrane protein 11																		TGGAGGCAAAACAACAAAAAC	0.443000													11	46					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52520476	52520476	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr14:52520476T>C	ENST00000216286.5	-	5	1249	c.1250A>G	c.(1249-1251)aAc>aGc	p.N417S	NID2_ENST00000541773.1_Missense_Mutation_p.N364S	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	417						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					GATGCTTCCGTTTTCGGGGTA	0.557000													31	83					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26286730	26286730	+	Missense_Mutation	SNP	A	A	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr22:26286730A>T	ENST00000335473.7	+	26	4572	c.4322A>T	c.(4321-4323)gAc>gTc	p.D1441V	CTA-125H2.2_ENST00000600211.1_RNA|MYO18B_ENST00000536101.1_Missense_Mutation_p.D1441V|CTA-125H2.2_ENST00000453457.2_RNA|MYO18B_ENST00000407587.2_Missense_Mutation_p.D1442V	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1441	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CAGATTGCTGACTTGACCTCT	0.582000													6	20					0	0	1	0	0
KCNK5	8645	broad.mit.edu	37	6	39163706	39163706	+	Missense_Mutation	SNP	T	T	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr6:39163706T>A	ENST00000359534.3	-	2	582	c.244A>T	c.(244-246)Aac>Tac	p.N82Y		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	82					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						CAGTTCCAGTTGTTGAAGGTC	0.502000													17	19					0	0	1	0	0
PTCHD4	442213	broad.mit.edu	37	6	47847438	47847438	+	Missense_Mutation	SNP	T	T	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr6:47847438T>A	ENST00000339488.4	-	3	1175	c.1142A>T	c.(1141-1143)tAc>tTc	p.Y381F		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	381	SSD.					integral to membrane	hedgehog receptor activity										GGAGAAAATGTAGAAGTAGTT	0.448000													15	26					0	0	1	0	0
TRA2A	29896	broad.mit.edu	37	7	23556149	23556149	+	Splice_Site	SNP	T	T	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr7:23556149T>A	ENST00000297071.4	-	3	387		c.e3-2		TRA2A_ENST00000538367.1_Splice_Site|TRA2A_ENST00000474586.1_Splice_Site|TRA2A_ENST00000392502.4_Splice_Site	NM_013293.3	NP_037425.1	Q13595	TRA2A_HUMAN	transformer 2 alpha homolog (Drosophila)						nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	10						GACCTCGACCTTTGAGAGAAA	0.408000													30	28					0	0	1	0	0
ZNF679	168417	broad.mit.edu	37	7	63721228	63721228	+	Missense_Mutation	SNP	G	G	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr7:63721228G>C	ENST00000421025.1	+	4	452	c.183G>C	c.(181-183)aaG>aaC	p.K61N	ZNF679_ENST00000255746.4_Missense_Mutation_p.K61N	NM_001159524.1|NM_153363.2	NP_001152996.1|NP_699194.2	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	61	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|skin(1)|stomach(1)	18						CTGTCTCTAAGCCAGACTTGA	0.353000													3	54					0	0	1	0	0
GJA5	2702	broad.mit.edu	37	1	147230980	147230980	+	Missense_Mutation	SNP	A	A	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr1:147230980A>T	ENST00000271348.2	-	2	528	c.367T>A	c.(367-369)Tac>Aac	p.Y123N	GJA5_ENST00000369237.1_Missense_Mutation_p.Y123N	NM_005266.5|NM_181703.2	NP_005257.2|NP_859054.1	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	123					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			GGGTACTCGTAAGAGCCAGAG	0.607000													27	88					0	0	1	0	0
INPP5B	3633	broad.mit.edu	37	1	38338661	38338661	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr1:38338661T>C	ENST00000373023.2	-	19	2461	c.2368A>G	c.(2368-2370)Aca>Gca	p.T790A	INPP5B_ENST00000373027.1_Missense_Mutation_p.T546A|INPP5B_ENST00000373024.3_Missense_Mutation_p.T710A|INPP5B_ENST00000373026.1_Missense_Mutation_p.T790A	NM_005540.2	NP_005531.2	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	790					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(9)|urinary_tract(1)	15	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TAACACAGTGTATGAATGGGA	0.443000													9	38					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89702352	89702352	+	Silent	SNP	T	T	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr4:89702352T>C	ENST00000264344.5	-	11	1629	c.1422A>G	c.(1420-1422)aaA>aaG	p.K474K	FAM13A_ENST00000395002.2_Silent_p.K148K|FAM13A_ENST00000508369.1_Silent_p.K148K|FAM13A_ENST00000511976.1_Intron|FAM13A_ENST00000502459.1_5'UTR|FAM13A_ENST00000513837.1_Silent_p.K120K|FAM13A_ENST00000503556.1_Silent_p.K134K	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	474					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						GCTCAGAAAGTTTAGTACTGG	0.358000													31	69					0	0	1	0	0
UBR2	23304	broad.mit.edu	37	6	42657359	42657359	+	Missense_Mutation	SNP	T	T	G			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr6:42657359T>G	ENST00000372901.1	+	46	5335	c.5077T>G	c.(5077-5079)Tat>Gat	p.Y1693D	UBR2_ENST00000372883.3_3'UTR|UBR2_ENST00000372899.1_Missense_Mutation_p.Y1693D			Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	1693					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			AGGCTGTTTTTATTCTCCTCC	0.468000													128	302					0	0	1	0	0
CCT2	10576	broad.mit.edu	37	12	69985925	69985925	+	Missense_Mutation	SNP	A	A	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr12:69985925A>T	ENST00000543146.2	+	8	1077	c.595A>T	c.(595-597)Aca>Tca	p.T199S	CCT2_ENST00000299300.6_Missense_Mutation_p.T246S|CCT2_ENST00000544368.2_Missense_Mutation_p.T246S	NM_001198842.1	NP_001185771.1	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2 (beta)	246					'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(1)	24	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TGGTATGGATACAGACAAAAT	0.333000													24	45					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95070306	95070306	+	Missense_Mutation	SNP	T	T	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr10:95070306T>A	ENST00000371501.4	-	52	6106	c.5984A>T	c.(5983-5985)aAg>aTg	p.K1995M	MYOF_ENST00000359263.4_Missense_Mutation_p.K1995M|MYOF_ENST00000358334.5_Missense_Mutation_p.K1982M|MYOF_ENST00000371502.4_Missense_Mutation_p.K1985M			Q9NZM1	MYOF_HUMAN	myoferlin	1995					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TAAGTCCAGCTTGGGGTTCAT	0.562000													19	56					0	0	1	0	0
CTNNB1	1499	broad.mit.edu	37	3	41266100	41266100	+	Missense_Mutation	SNP	T	T	G	rs121913416		TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr3:41266100T>G	ENST00000349496.5	+	3	377	c.97T>G	c.(97-99)Tct>Gct	p.S33A	CTNNB1_ENST00000396183.3_Missense_Mutation_p.S33A|CTNNB1_ENST00000405570.1_Missense_Mutation_p.S33A|CTNNB1_ENST00000396185.3_Missense_Mutation_p.S33A|CTNNB1_ENST00000453024.1_Missense_Mutation_p.S26A	NM_001904.3	NP_001895.1	P35222	CTNB1_HUMAN	catenin (cadherin-associated protein), beta 1, 88kDa	33			Missing (in hepatocellular carcinoma).|S -> F (in PTR, MDB and hepatocellular carcinoma).|S -> L (in hepatocellular carcinoma).|S -> Y (in colorectal cancer and PTR; enhances transactivation of target genes).		adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.A5_A80del(53)|p.S33P(47)|p.S33A(16)|p.A5_Q143del(7)|p.A5_A80>D(7)|p.Q28_H134del(5)|p.W25_D32del(4)|p.S33L(4)|p.?(4)|p.V22_G38del(3)|p.W25_I140del(3)|p.T3_A126del(2)|p.S33N(2)|p.S23_S33del(2)|p.V22_S33del(2)|p.A5fs*7(2)|p.D32_S47del(2)|p.M5_N141>D(2)|p.L10_N141del(2)|p.A5_Y142>D(2)|p.Y30_S33del(2)|p.A5_Q143>E(1)|p.A13_R151del(1)|p.M14_S45del(1)|p.A20_N141del(1)|p.M1_A87del(1)|p.D11_Y142>H(1)|p.H24_G38del(1)|p.S23_I35del(1)|p.Y30_A97del(1)|p.W25_S33del(1)|p.V22_T102del(1)|p.A20_A80del(1)|p.V22_S71>A(1)|p.Q28_A43del(1)|p.A5_T59del(1)|p.D32fs*9(1)|p.A20_I35del(1)|p.M1_V173del(1)|p.E15_I140>V(1)|p.S23_A39del(1)|p.H24_M131del(1)|p.A21_A80del(1)|p.Y30_A80del(1)|p.A5_T40del(1)|p.S29_H36del(1)|p.A5_E54del(1)|p.W25_I35del(1)|p.S33_S37del(1)|p.M8_A80del(1)|p.P16_K133del(1)|p.D32_S33insS(1)|p.V22_Y64del(1)|p.Q28_Q61del(1)|p.A20_S111del(1)|p.Y30_T40del(1)|p.S33T(1)|p.D32_H36>D(1)|p.A5_I35del(1)|p.D32_H36del(1)	CTNNB1/PLAG1(60)	NS(4)|adrenal_gland(103)|biliary_tract(43)|bone(21)|breast(7)|central_nervous_system(260)|cervix(9)|endometrium(293)|eye(1)|haematopoietic_and_lymphoid_tissue(60)|kidney(202)|large_intestine(269)|liver(1010)|lung(63)|oesophagus(6)|ovary(106)|pancreas(126)|parathyroid(11)|pituitary(111)|pleura(2)|prostate(31)|salivary_gland(13)|skin(103)|small_intestine(17)|soft_tissue(792)|stomach(165)|thyroid(55)|upper_aerodigestive_tract(2)|urinary_tract(8)	3893				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	TTACCTGGACTCTGGAATCCA	0.488000		15	"""H, Mis, T"""	PLAG1	"""colorectal, cvarian,  hepatoblastoma, others, pleomorphic salivary adenoma"""				Pilomatrixoma, Familial Clustering of				3	39					0	0	1	0	0
IARS	3376	broad.mit.edu	37	9	95043126	95043126	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr9:95043126T>C	ENST00000375643.3	-	7	913	c.647A>G	c.(646-648)gAa>gGa	p.E216G	IARS_ENST00000375629.3_5'UTR|IARS_ENST00000443024.2_Missense_Mutation_p.E216G|IARS_ENST00000447699.2_Missense_Mutation_p.E106G	NM_013417.2	NP_038203.2	P41252	SYIC_HUMAN	isoleucyl-tRNA synthetase	216					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	35					L-Isoleucine(DB00167)	AGATACAGTTTCATCTTCTTC	0.353000													10	25					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167289254	167289254	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr2:167289254G>T	ENST00000409855.1	-	15	2292	c.2166C>A	c.(2164-2166)taC>taA	p.Y722*		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	722					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						CCAGAAACAGGTAAAGTACCT	0.328000													4	12					0.00909568	0.00926257	1	1	0
ARHGEF10L	55160	broad.mit.edu	37	1	17914091	17914091	+	Missense_Mutation	SNP	G	G	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr1:17914091G>C	ENST00000361221.3	+	3	333	c.174G>C	c.(172-174)gaG>gaC	p.E58D	ARHGEF10L_ENST00000375415.1_Missense_Mutation_p.E58D|ARHGEF10L_ENST00000452522.1_Missense_Mutation_p.E58D|ARHGEF10L_ENST00000434513.1_Missense_Mutation_p.E58D	NM_018125.3	NP_060595.3	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	58					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		TTGCTCCTGAGAGGGACACAG	0.587000													78	211					0	0	1	0	0
VEPH1	79674	broad.mit.edu	37	3	157081347	157081347	+	Missense_Mutation	SNP	A	A	G			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr3:157081347A>G	ENST00000362010.2	-	9	1848	c.1541T>C	c.(1540-1542)aTa>aCa	p.I514T	RP11-550I24.2_ENST00000487238.1_RNA|VEPH1_ENST00000392833.2_Missense_Mutation_p.I514T|VEPH1_ENST00000543418.1_Missense_Mutation_p.I514T|VEPH1_ENST00000392832.2_Missense_Mutation_p.I514T	NM_001167912.1	NP_001161384.1	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain-containing 1	514						plasma membrane				autonomic_ganglia(1)|breast(5)|cervix(1)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|pancreas(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			GTCTATATGTATAATATTTGG	0.413000													31	76					0	0	1	0	0
LUZP1	7798	broad.mit.edu	37	1	23419974	23419974	+	Missense_Mutation	SNP	G	G	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr1:23419974G>T	ENST00000302291.4	-	4	1582	c.781C>A	c.(781-783)Ctg>Atg	p.L261M	LUZP1_ENST00000314174.5_Missense_Mutation_p.L261M|LUZP1_ENST00000374623.3_Missense_Mutation_p.L261M|LUZP1_ENST00000418342.1_Missense_Mutation_p.L261M			Q86V48	LUZP1_HUMAN	leucine zipper protein 1	261						nucleus				NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(12)|upper_aerodigestive_tract(2)	31		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		AGGTAGTCCAGACCACCCTTC	0.408000													19	38					7.41877e-09	7.76872e-09	1	1	0
ZNF98	148198	broad.mit.edu	37	19	22575729	22575729	+	Missense_Mutation	SNP	T	T	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr19:22575729T>A	ENST00000357774.5	-	4	429	c.308A>T	c.(307-309)tAt>tTt	p.Y103F		NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				TTTTTGGAAATAATTTTTTTT	0.303000													6	21					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32599590	32599590	+	Nonsense_Mutation	SNP	G	G	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr8:32599590G>T	ENST00000341377.5	+	7	1214	c.697G>T	c.(697-699)Gaa>Taa	p.E233*	NRG1_ENST00000287840.5_Nonsense_Mutation_p.E233*|NRG1_ENST00000405005.2_Nonsense_Mutation_p.E233*|NRG1_ENST00000520502.2_Intron|NRG1_ENST00000287842.3_Intron|NRG1_ENST00000338921.4_Nonsense_Mutation_p.E233*|NRG1_ENST00000539990.1_Intron|NRG1_ENST00000356819.4_Intron|NRG1_ENST00000521670.1_Nonsense_Mutation_p.E233*|NRG1_ENST00000519301.1_Intron|NRG1_ENST00000287845.5_Intron|NRG1_ENST00000523079.1_Intron|NRG1_ENST00000520407.1_Intron			Q02297	NRG1_HUMAN	neuregulin 1	233					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		CCAAAACCAAGAAAGTATGTC	0.398000													16	29					1.5739e-10	1.69614e-10	1	1	0
CARD6	84674	broad.mit.edu	37	5	40853136	40853136	+	Silent	SNP	C	C	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr5:40853136C>T	ENST00000254691.5	+	3	1901	c.1702C>T	c.(1702-1704)Cta>Tta	p.L568L	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	568					apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						ATGGGACTTGCTAATGTTTTT	0.398000													8	129					0	0	1	0	0
TRUB2	26995	broad.mit.edu	37	9	131071863	131071863	+	Missense_Mutation	SNP	G	G	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr9:131071863G>C	ENST00000372890.4	-	8	1295	c.962C>G	c.(961-963)tCt>tGt	p.S321C	TRUB2_ENST00000546104.1_Missense_Mutation_p.S265C	NM_015679.1	NP_056494.1	O95900	TRUB2_HUMAN	TruB pseudouridine (psi) synthase family member 2	321					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			kidney(2)|large_intestine(2)|lung(3)|ovary(1)	8						CCCCAAGGTAGAGCTCGGGCC	0.622000													26	69					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52595854	52595854	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr10:52595854G>A	ENST00000395489.2	-	8	959	c.563C>T	c.(562-564)gCg>gTg	p.A188V	A1CF_ENST00000373995.3_Missense_Mutation_p.A203V|A1CF_ENST00000395495.1_Missense_Mutation_p.A195V|A1CF_ENST00000282641.2_Missense_Mutation_p.A195V|A1CF_ENST00000374001.1_Missense_Mutation_p.A195V|A1CF_ENST00000373993.1_Missense_Mutation_p.A195V|A1CF_ENST00000373997.3_Missense_Mutation_p.A195V	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	195	RRM 2.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding	p.A203V(2)|p.A195V(2)		NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						TTTCCTCCTCGCCATGGCAGC	0.488000													22	66					0	0	1	0	0
XKR3	150165	broad.mit.edu	37	22	17288741	17288741	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr22:17288741T>C	ENST00000331428.5	-	2	325	c.223A>G	c.(223-225)Att>Gtt	p.I75V		NM_175878.3	NP_787074.2	Q5GH77	XKR3_HUMAN	XK, Kell blood group complex subunit-related family, member 3	75						integral to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GCCCCCACAATAATAAAGCTG	0.353000													28	48					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16956761	16956761	+	RNA	SNP	C	C	G			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr1:16956761C>G	ENST00000412962.1	-	0	294																											CCTGGACCTGCCCTGGGGCAG	0.647000													3	14					0	0	1	0	0
WFDC6	140870	broad.mit.edu	37	20	44167963	44167963	+	Silent	SNP	G	G	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr20:44167963G>A	ENST00000600168.1	-	1	171	c.84C>T	c.(82-84)atC>atT	p.I28I	WFDC6_ENST00000372670.3_Silent_p.I28I|EPPIN_ENST00000555685.1_Intron|EPPIN-WFDC6_ENST00000504988.1_Intron					WAP four-disulfide core domain 6											breast(1)|kidney(1)|large_intestine(2)|lung(2)	6		Myeloproliferative disorder(115;0.0122)				TACTGCCAAGGATGCCTTCAG	0.478000													6	63					0	0	1	0	0
A2ML1	144568	broad.mit.edu	37	12	9013852	9013852	+	Missense_Mutation	SNP	A	A	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr12:9013852A>C	ENST00000299698.7	+	28	3641	c.3461A>C	c.(3460-3462)aAc>aCc	p.N1154T	A2ML1_ENST00000539547.1_Missense_Mutation_p.N663T	NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	998						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						GACATCAGAAACATTCTCCTT	0.448000													25	92					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60687905	60687905	+	Silent	SNP	G	G	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr2:60687905G>A	ENST00000335712.6	-	4	2369	c.2142C>T	c.(2140-2142)agC>agT	p.S714S	BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000538214.1_Silent_p.S680S|BCL11A_ENST00000537768.1_Silent_p.S383S|BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000358510.4_Silent_p.S680S|BCL11A_ENST00000356842.4_Silent_p.S714S	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	714					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TTCCCGTGCCGCTGCGCCCCG	0.652000			T	IGH@	B-CLL								6	98					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	28807502	28807502	+	Silent	SNP	T	T	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chrX:28807502T>A	ENST00000378993.1	+	2	715	c.42T>A	c.(40-42)acT>acA	p.T14T	IL1RAPL1_ENST00000302196.4_Silent_p.T14T	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	14					innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						TATACGCTACTTTTACTCAGA	0.368000													3	34					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87484336	87484336	+	Missense_Mutation	SNP	A	A	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr10:87484336A>T	ENST00000327946.7	-	11	1716	c.1631T>A	c.(1630-1632)cTa>cAa	p.L544Q	GRID1_ENST00000536331.1_Missense_Mutation_p.L115Q	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	544						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	CTTCTTAATTAGAATCCCCAC	0.522000										Multiple Myeloma(13;0.14)			32	44					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681549	100681549	+	Missense_Mutation	SNP	A	A	G			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr7:100681549A>G	ENST00000306151.4	+	3	6916	c.6852A>G	c.(6850-6852)atA>atG	p.I2284M		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2284	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TAACAAGTATACCTGTCAGCC	0.463000													160	402					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76497832	76497832	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr17:76497832C>T	ENST00000585328.1	-	34	5429	c.5305G>A	c.(5305-5307)Gtg>Atg	p.V1769M	DNAH17_ENST00000389840.5_Splice_Site|DNAH17-AS1_ENST00000598378.1_3'UTR	NM_173628.3	NP_775899.3			dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GCCTTGGCCACGATCATTTTG	0.617000													4	143					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135024207	135024207	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr10:135024207G>A	ENST00000304613.3	+	21	3908	c.3887G>A	c.(3886-3888)cGc>cAc	p.R1296H	KNDC1_ENST00000368572.2_Missense_Mutation_p.R1298H			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	1296	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction			p.R1296H(1)		NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CTCCTCGACCGCATCAACAGC	0.622000													4	185					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38684211	38684211	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr19:38684211C>T	ENST00000222345.6	+	18	5140	c.4631C>T	c.(4630-4632)tCg>tTg	p.S1544L		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	1544					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CGGACGCTGTCGGACGAGAGC	0.697000													4	12					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15791307	15791307	+	Missense_Mutation	SNP	A	A	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr19:15791307A>C	ENST00000550308.1	+	5	883	c.503A>C	c.(502-504)aAc>aCc	p.N168T	CYP4F12_ENST00000324632.9_Missense_Mutation_p.N168T	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					ACGATCTTCAACAAGAGTGCA	0.532000													12	38					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62751641	62751641	+	Missense_Mutation	SNP	G	G	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr3:62751641G>T	ENST00000383710.4	-	2	809	c.460C>A	c.(460-462)Cag>Aag	p.Q154K	CADPS_ENST00000490353.2_Missense_Mutation_p.Q154K|CADPS_ENST00000283269.9_Missense_Mutation_p.Q154K|CADPS_ENST00000357948.3_Missense_Mutation_p.Q154K	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	154					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TTGACTGTCTGCAGCTGCTGT	0.468000													33	58					1.30293e-26	1.4179e-26	1	1	0
DHFR	1719	broad.mit.edu	37	5	79933789	79933789	+	Silent	SNP	T	T	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr5:79933789T>C	ENST00000439211.2	-	4	775	c.282A>G	c.(280-282)ctA>ctG	p.L94L	DHFR_ENST00000505337.1_Silent_p.L94L|DHFR_ENST00000504396.1_Silent_p.L42L|DHFR_ENST00000511032.1_Silent_p.L94L|DHFR_ENST00000513048.1_Intron	NM_000791.3	NP_000782.1	P00374	DYR_HUMAN	dihydrofolate reductase	94	DHFR.				folic acid metabolic process|glycine biosynthetic process|nucleotide biosynthetic process|one-carbon metabolic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to methotrexate|tetrahydrofolate metabolic process	cytosol	dihydrofolate reductase activity|drug binding|folate reductase activity|NADP binding			kidney(1)|large_intestine(1)	2		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.69e-46)|Epithelial(54;7.49e-41)|all cancers(79;1.54e-35)	Dapsone(DB00250)|Dimethyl sulfoxide(DB01093)|Lamotrigine(DB00555)|Methotrexate(DB00563)|NADH(DB00157)|Pemetrexed(DB00642)|Proguanil(DB01131)|Pyrimethamine(DB00205)|Trimethoprim(DB00440)|Trimetrexate(DB01157)	AGGCATCATCTAGACTTCTGG	0.353000													21	52					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145296373	145296373	+	Missense_Mutation	SNP	G	G	T	rs3969711		TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr1:145296373G>T	ENST00000342960.5	+	3	330	c.295G>T	c.(295-297)Gtt>Ttt	p.V99F	RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	99								p.V99F(1)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TAAAGTCCTAGTTCACTCTCA	0.473000													5	186					3.59834e-05	3.73285e-05	1	1	0
CXADR	1525	broad.mit.edu	37	21	18924261	18924261	+	Silent	SNP	G	G	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr21:18924261G>T	ENST00000284878.7	+	3	1153	c.405G>T	c.(403-405)ctG>ctT	p.L135L	CXADR_ENST00000306618.10_Silent_p.L135L|CXADR_ENST00000400165.1_Silent_p.L135L|CXADR_ENST00000356275.6_Intron|CXADR_ENST00000400166.1_Silent_p.L135L|CXADR_ENST00000400169.1_Silent_p.L135L	NM_001338.4	NP_001329.1	P78310	CXAR_HUMAN	coxsackie virus and adenovirus receptor	135					blood coagulation|cell adhesion|interspecies interaction between organisms|leukocyte migration|regulation of immune response	adherens junction|basolateral plasma membrane|extracellular region|integral to plasma membrane|nucleus|tight junction	receptor activity			endometrium(2)|large_intestine(5)|lung(1)|ovary(1)|prostate(2)	11				Epithelial(23;0.000206)|all cancers(11;0.000302)|OV - Ovarian serous cystadenocarcinoma(11;0.0194)|Lung(58;0.0233)|COAD - Colon adenocarcinoma(22;0.0389)|Colorectal(24;0.0483)|LUSC - Lung squamous cell carcinoma(23;0.0782)		AGATTCATCTGGTAGTTCTTG	0.333000													3	40					0.115264	0.116312	1	1	0
SPOP	8405	broad.mit.edu	37	17	47696644	47696644	+	Missense_Mutation	SNP	A	A	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr17:47696644A>C	ENST00000393331.3	-	6	774	c.304T>G	c.(304-306)Ttc>Gtc	p.F102V	SPOP_ENST00000504102.1_Missense_Mutation_p.F102V|SPOP_ENST00000503676.1_Missense_Mutation_p.F102V|SPOP_ENST00000393328.2_Missense_Mutation_p.F102V|SPOP_ENST00000347630.2_Missense_Mutation_p.F102V	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	102	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding			endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						GAGAATTTGAATTTTGCCCGA	0.408000										Prostate(2;0.17)			30	37					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216246269	216246269	+	Missense_Mutation	SNP	A	A	G			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr1:216246269A>G	ENST00000366943.2	-	29	6205	c.5819T>C	c.(5818-5820)gTa>gCa	p.V1940A	RP11-22M7.2_ENST00000445619.1_RNA|RP11-22M7.2_ENST00000430890.1_RNA|USH2A_ENST00000307340.3_Missense_Mutation_p.V1940A|RP11-22M7.2_ENST00000446411.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1940	Fibronectin type-III 5.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATCACTATATACTGAACCTCC	0.368000										HNSCC(13;0.011)			25	60					0	0	1	0	0
VARS	7407	broad.mit.edu	37	6	31747573	31747573	+	Missense_Mutation	SNP	G	G	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr6:31747573G>C	ENST00000375663.3	-	27	3540	c.3100C>G	c.(3100-3102)Ctg>Gtg	p.L1034V		NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	1034					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	ACCCCATTCAGTACAGGTTTC	0.622000													5	40					0	0	1	0	0
PHIP	55023	broad.mit.edu	37	6	79770385	79770385	+	Splice_Site	SNP	T	T	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr6:79770385T>A	ENST00000275034.4	-	5	507	c.340_splice	c.e5+1	p.S114_splice		NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	114					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		ATTTTCATACTTTTATTTGTG	0.333000													7	53					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96802756	96802756	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr10:96802756T>C	ENST00000371270.3	-	7	1134	c.1040A>G	c.(1039-1041)tAc>tGc	p.Y347C	CYP2C8_ENST00000535898.1_Missense_Mutation_p.Y245C|CYP2C8_ENST00000539050.1_Missense_Mutation_p.Y261C	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	347					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	AGCATCAGTGTAAGGCATGTG	0.498000													31	79					0	0	1	0	0
PCDHA5	0	broad.mit.edu	37	5	140201645	140201645	+	Silent	SNP	C	C	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr5:140201645C>T	ENST00000529859.1	+	1	285	c.285C>T	c.(283-285)tgC>tgT	p.C95C	PCDHA5_ENST00000378126.3_Silent_p.C95C|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Silent_p.C95C|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGAGCTGTGCCGGCGGAGGG	0.587000													5	260					0	0	1	0	0
OR1G1	8390	broad.mit.edu	37	17	3030696	3030696	+	Silent	SNP	A	A	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr17:3030696A>T	ENST00000328890.2	-	1	179	c.150T>A	c.(148-150)atT>atA	p.I50I		NM_003555.1	NP_003546.1	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G, member 1	50					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(3)|skin(3)	11						GAGTGTCAGTAATGATGACTA	0.517000													35	98					0	0	1	0	0
SLC25A17	10478	broad.mit.edu	37	22	41169988	41169988	+	Silent	SNP	T	T	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr22:41169988T>C	ENST00000402844.3	-	4	1463	c.483A>G	c.(481-483)acA>acG	p.T161T	SLC25A17_ENST00000435456.2_Silent_p.T243T|SLC25A17_ENST00000491545.1_5'UTR|SLC25A17_ENST00000542412.1_Silent_p.T170T|SLC25A17_ENST00000544408.1_Silent_p.T206T			O43808	PM34_HUMAN	solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17	243					fatty acid alpha-oxidation	integral to plasma membrane|mitochondrial inner membrane|peroxisomal membrane	adenine nucleotide transmembrane transporter activity|protein binding			central_nervous_system(1)|large_intestine(4)|lung(2)|skin(1)	8						GACTTCCCAATGTTCTGTTTT	0.408000													9	42					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53578098	53578098	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chrX:53578098G>A	ENST00000342160.3	-	64	9606	c.9149C>T	c.(9148-9150)gCc>gTc	p.A3050V	HUWE1_ENST00000262854.6_Missense_Mutation_p.A3050V			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	3050					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						GTCTGAGCTGGCATTCTGTGC	0.552000													3	42					0	0	1	0	0
NT5M	56953	broad.mit.edu	37	17	17250218	17250218	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr17:17250218C>T	ENST00000389022.4	+	5	860	c.644C>T	c.(643-645)gCg>gTg	p.A215V	NT5M_ENST00000582909.1_3'UTR	NM_020201.3	NP_064586.1	Q9NPB1	NT5M_HUMAN	5',3'-nucleotidase, mitochondrial	215					DNA replication|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	5'-nucleotidase activity|metal ion binding|nucleotide binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4						CACTCGTGGGCGGACGACTGG	0.692000													24	57					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186099650	186099650	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr1:186099650T>C	ENST00000271588.4	+	85	13280	c.13051T>C	c.(13051-13053)Ttc>Ctc	p.F4351L	HMCN1_ENST00000367492.2_Missense_Mutation_p.F4351L	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4351	Ig-like C2-type 43.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ACCTCCAGTCTTCAAAGGTGA	0.393000													20	57					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29633900	29633900	+	Missense_Mutation	SNP	A	A	G	rs60081496	by1000genomes	TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr20:29633900A>G	ENST00000278882.3	+	9	919	c.539A>G	c.(538-540)gAa>gGa	p.E180G	FRG1B_ENST00000358464.4_Missense_Mutation_p.E180G														p.E180G(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAAACAAGAGAACCAAATTGA	0.264000													3	48					0	0	1	0	0
DDX3Y	8653	broad.mit.edu	37	Y	15028970	15028970	+	Missense_Mutation	SNP	A	A	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chrY:15028970A>T	ENST00000336079.3	+	15	1867	c.1761A>T	c.(1759-1761)aaA>aaT	p.K587N	DDX3Y_ENST00000360160.4_Missense_Mutation_p.K587N	NM_001122665.1|NM_004660.3	NP_001116137.1|NP_004651.2	O15523	DDX3Y_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked	587						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|RNA binding			kidney(1)|liver(2)|lung(1)|upper_aerodigestive_tract(1)	5						GACGATCTAAAAGGTACACAC	0.393000													3	3					0	0	1	0	0
TEKT3	64518	broad.mit.edu	37	17	15234581	15234581	+	Missense_Mutation	SNP	G	G	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr17:15234581G>C	ENST00000395930.1	-	3	508	c.322C>G	c.(322-324)Caa>Gaa	p.Q108E	TEKT3_ENST00000338696.2_Missense_Mutation_p.Q108E	NM_031898.2	NP_114104.1	Q9BXF9	TEKT3_HUMAN	tektin 3	108					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				endometrium(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	23				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		TTGGACTCTTGATAGTTGGTT	0.423000													17	162					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94066494	94066494	+	Missense_Mutation	SNP	G	G	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr6:94066494G>C	ENST00000369303.4	-	5	1449	c.1265C>G	c.(1264-1266)tCt>tGt	p.S422C		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	422	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		GCTTAAGTCAGAAACTCCATT	0.433000													14	59					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34149502	34149502	+	Nonsense_Mutation	SNP	A	A	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chrX:34149502A>T	ENST00000346193.3	-	1	945	c.894T>A	c.(892-894)tgT>tgA	p.C298*		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	298										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						AGAATTTCCCACAAGGGTATT	0.592000													16	5					0	0	1	0	0
ZRSR1	7310	broad.mit.edu	37	5	112227407	112227407	+	Missense_Mutation	SNP	A	A	G			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr5:112227407A>G	ENST00000391338.1	+	1	95	c.71A>G	c.(70-72)tAc>tGc	p.Y24C	REEP5_ENST00000474542.2_Intron|REEP5_ENST00000513339.1_Intron|REEP5_ENST00000545426.1_Intron|REEP5_ENST00000504247.1_Intron|SRP19_ENST00000512790.1_3'UTR|REEP5_ENST00000379638.4_Intron	NM_001204199.1	NP_001191128.1			zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1											breast(1)|skin(1)|stomach(2)	4						CACAAAAAGTACAGGGCCGCC	0.512000													7	35					0	0	1	0	0
RRN3P2	0	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													3	28					0	0	1	0	0
FGF23	8074	broad.mit.edu	37	12	4479847	4479847	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr12:4479847G>A	ENST00000237837.1	-	3	563	c.418C>T	c.(418-420)Cgg>Tgg	p.R140W		NM_020638.2	NP_065689.1	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23	140					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity	p.R140W(1)		NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	22			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			CTCTTCGCCCGGCCCAGACTG	0.577000													50	153					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								4	71					0	0	1	0	0
ZHX1	11244	broad.mit.edu	37	8	124266782	124266782	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr8:124266782C>T	ENST00000395571.3	-	3	2022	c.1405G>A	c.(1405-1407)Gca>Aca	p.A469T	ZHX1_ENST00000297857.2_Missense_Mutation_p.A469T|ZHX1_ENST00000522655.1_Missense_Mutation_p.A469T|ZHX1-C8ORF76_ENST00000357082.4_Intron	NM_001017926.2|NM_007222.4	NP_001017926.1|NP_009153.3	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	469	Required for interaction with NFYA.				negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			GTCTTTTTTGCCCGAATGCCA	0.388000													4	155					0	0	1	0	0
ZNF365	22891	broad.mit.edu	37	10	64403689	64403689	+	Missense_Mutation	SNP	T	T	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr10:64403689T>A	ENST00000395251.1	+	2	338	c.4T>A	c.(4-6)Tct>Act	p.S2T	ZNF365_ENST00000395249.1_Missense_Mutation_p.S2T|ZNF365_ENST00000410046.3_Intron	NM_199452.3	NP_955524.3	Q70YC4	TALAN_HUMAN	zinc finger protein 365	2										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					TTAATTAATGTCTGCGCTGGG	0.453000													14	75					0	0	1	0	0
NFATC1	4772	broad.mit.edu	37	18	77208864	77208864	+	Missense_Mutation	SNP	C	C	G			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr18:77208864C>G	ENST00000253506.5	+	4	1838	c.1469C>G	c.(1468-1470)gCc>gGc	p.A490G	NFATC1_ENST00000318065.5_Missense_Mutation_p.A477G|NFATC1_ENST00000397790.2_Missense_Mutation_p.A18G|NFATC1_ENST00000587635.1_Missense_Mutation_p.A490G|NFATC1_ENST00000592223.1_Missense_Mutation_p.A477G|NFATC1_ENST00000591814.1_Missense_Mutation_p.A490G|NFATC1_ENST00000586434.1_Missense_Mutation_p.A477G|NFATC1_ENST00000329101.4_Missense_Mutation_p.A477G|NFATC1_ENST00000545796.1_Missense_Mutation_p.A18G|NFATC1_ENST00000542384.1_Missense_Mutation_p.A490G|NFATC1_ENST00000427363.2_Missense_Mutation_p.A490G	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	490	RHD.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CGCCCGCACGCCTTCTACCAG	0.612000													31	63					0	0	1	0	0
TAAR9	134860	broad.mit.edu	37	6	132860433	132860433	+	RNA	SNP	G	G	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr6:132860433G>A	ENST00000434551.1	+	0	1005					NM_175057.3	NP_778227.3	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9 (gene/pseudogene)							plasma membrane	G-protein coupled receptor activity					Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		GGACTGATTCGTCAACAACTA	0.328000													7	19					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169508849	169508849	+	Missense_Mutation	SNP	T	T	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr5:169508849T>A	ENST00000256935.8	+	51	5371	c.5291T>A	c.(5290-5292)cTg>cAg	p.L1764Q	DOCK2_ENST00000520908.1_Missense_Mutation_p.L1256Q|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000540750.1_Missense_Mutation_p.L825Q	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1764					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTTCCAGCCCTGGCGCTCTCA	0.627000													17	43					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000332482.4_Silent_p.Q2688Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													6	69					0	0	1	0	0
RPS11	6205	broad.mit.edu	37	19	50000530	50000530	+	Missense_Mutation	SNP	A	A	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr19:50000530A>C	ENST00000270625.2	+	2	178	c.95A>C	c.(94-96)aAg>aCg	p.K32T	RPS11_ENST00000599561.1_Missense_Mutation_p.K32T|RPS11_ENST00000596873.1_Missense_Mutation_p.K32T|RPS11_ENST00000594493.1_5'UTR	NM_001015.4	NP_001006.1	P62280	RS11_HUMAN	ribosomal protein S11	32					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|rRNA binding|structural constituent of ribosome			kidney(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	7		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00206)|GBM - Glioblastoma multiforme(486;0.0245)		GGCAAGGAGAAGCTCCCGCGG	0.532000													16	63					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13606062	13606062	+	Missense_Mutation	SNP	C	C	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr4:13606062C>T	ENST00000040738.5	-	10	2597	c.2462G>A	c.(2461-2463)cGt>cAt	p.R821H		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	821	Lys-rich.						DNA binding										GTTTTCTTTACGAACATTCTC	0.323000													3	18					0	0	1	0	0
ATXN2	6311	broad.mit.edu	37	12	111954061	111954061	+	Silent	SNP	C	C	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr12:111954061C>A	ENST00000377617.3	-	10	1913	c.1752G>T	c.(1750-1752)ccG>ccT	p.P584P	ATXN2_ENST00000389153.4_Silent_p.P319P|ATXN2_ENST00000542287.2_Silent_p.P319P|ATXN2_ENST00000535949.1_Silent_p.P295P|ATXN2_ENST00000550104.1_Silent_p.P584P	NM_002973.3	NP_002964.3	Q99700	ATX2_HUMAN	ataxin 2	584	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37						GCCTGGAGGGCGGCCGTGTAG	0.637000													8	26					0.00448238	0.00460689	1	1	0
SLAMF6	114836	broad.mit.edu	37	1	160466070	160466070	+	Missense_Mutation	SNP	A	A	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr1:160466070A>T	ENST00000368059.3	-	2	232	c.163T>A	c.(163-165)Tgg>Agg	p.W55R	SLAMF6_ENST00000368057.3_Missense_Mutation_p.W55R|SLAMF6_ENST00000368055.1_Intron	NM_001184714.1|NM_001184715.1|NM_001184716.1|NM_052931.4	NP_001171643.1|NP_001171644.1|NP_001171645.1|NP_443163.1	Q96DU3	SLAF6_HUMAN	SLAM family member 6	55						integral to membrane|plasma membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(4)	22	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			TTGAAAAGCCAAGTGATGAAG	0.463000													59	168					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167489162	167489162	+	Silent	SNP	A	A	G			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr5:167489162A>G	ENST00000519204.1	+	6	1162	c.1044A>G	c.(1042-1044)tcA>tcG	p.S348S	TENM2_ENST00000545108.1_Silent_p.S469S|TENM2_ENST00000518659.1_Silent_p.S469S|TENM2_ENST00000403607.2_Silent_p.S302S|TENM2_ENST00000520394.1_Silent_p.S237S					teneurin transmembrane protein 2																		TTTGGAGGTCACAAATTCACA	0.498000													24	61					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109691723	109691723	+	Missense_Mutation	SNP	C	C	G			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr9:109691723C>G	ENST00000277225.5	+	3	5819	c.5530C>G	c.(5530-5532)Ctc>Gtc	p.L1844V	ZNF462_ENST00000457913.1_Missense_Mutation_p.L1844V|ZNF462_ENST00000441147.2_Missense_Mutation_p.L689V			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1844					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						AATCGAGTGGCTCCCATTCCG	0.522000													33	58					0	0	1	0	0
NXPE1	120400	broad.mit.edu	37	11	114401240	114401240	+	Missense_Mutation	SNP	A	A	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr11:114401240A>T	ENST00000536312.1	-	6	1382	c.490T>A	c.(490-492)Tac>Aac	p.Y164N	NXPE1_ENST00000251921.2_Missense_Mutation_p.Y22N|NXPE1_ENST00000424269.1_Missense_Mutation_p.Y164N					neurexophilin and PC-esterase domain family, member 1																		CTGACCAGGTAGGTGCCATTG	0.587000													27	60					0	0	1	0	0
PPIAL4G	644591	broad.mit.edu	37	1	143767776	143767776	+	Missense_Mutation	SNP	A	A	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr1:143767776A>C	ENST00000419275.1	-	1	105	c.73T>G	c.(73-75)Ttt>Gtt	p.F25V		NM_001123068.1	NP_001116540.1	A2BFH1	PAL4G_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like 4G	25	PPIase cyclophilin-type.				protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity			breast(1)|endometrium(2)|kidney(1)|lung(8)|ovary(1)|skin(1)	14						TTGTCTGCAAACTGTTTGATG	0.478000													81	245					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123256220	123256220	+	Missense_Mutation	SNP	T	T	C			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr10:123256220T>C	ENST00000358487.5	-	13	1961	c.1689A>G	c.(1687-1689)atA>atG	p.I563M	FGFR2_ENST00000351936.6_Missense_Mutation_p.I561M|FGFR2_ENST00000360144.3_Missense_Mutation_p.I475M|FGFR2_ENST00000346997.2_Missense_Mutation_p.I561M|FGFR2_ENST00000369056.1_Missense_Mutation_p.I564M|FGFR2_ENST00000478859.1_Missense_Mutation_p.I335M|FGFR2_ENST00000369060.4_Missense_Mutation_p.I447M|FGFR2_ENST00000356226.4_Missense_Mutation_p.I446M|FGFR2_ENST00000357555.5_Missense_Mutation_p.I474M|FGFR2_ENST00000369059.1_Missense_Mutation_p.I449M|FGFR2_ENST00000457416.2_Missense_Mutation_p.I564M|FGFR2_ENST00000369061.4_Missense_Mutation_p.I451M	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	563	Protein kinase.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CATACTCAACTATGACATAGA	0.498000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				27	71					0	0	1	0	0
RP11-812E19.9	0	broad.mit.edu	37	16	33647512	33647512	+	Silent	SNP	A	A	G			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr16:33647512A>G	ENST00000558425.1	-	2	87	c.88T>C	c.(88-90)Ttg>Ctg	p.L30L																								GGCTGTACCAAGCCTCCCCCA	0.567000													7	164					0	0	1	0	0
KCNIP1	0	broad.mit.edu	37	5	170149724	170149724	+	Missense_Mutation	SNP	T	T	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr5:170149724T>A	ENST00000328939.4	+	5	872	c.335T>A	c.(334-336)gTa>gAa	p.V112E	KCNIP1_ENST00000411494.1_Missense_Mutation_p.V123E|KCNIP1_ENST00000377360.4_Missense_Mutation_p.V121E|KCNIP1_ENST00000390656.4_Missense_Mutation_p.V112E|KCNIP1_ENST00000520740.1_Missense_Mutation_p.V84E|KCNIP1_ENST00000434108.1_Missense_Mutation_p.V137E	NM_001034837.1|NM_014592.2	NP_001030009.1|NP_055407.1	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1	123	EF-hand 2.				detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			autonomic_ganglia(1)|large_intestine(7)|lung(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	18	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGGACTTTGTAACCGCTCTG	0.428000													7	35					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													3	66					0	0	1	0	0
ME1	4199	broad.mit.edu	37	6	84140595	84140595	+	Splice_Site	SNP	C	C	T			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr6:84140595C>T	ENST00000369705.3	-	1	195		c.e1+1		ME1_ENST00000543031.1_Splice_Site|ME1_ENST00000541327.1_Splice_Site	NM_002395.4	NP_002386.1	P48163	MAOX_HUMAN	malic enzyme 1, NADP(+)-dependent, cytosolic						carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			NS(2)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	TGCGGGTTTACCTTGTTGAGG	0.716000													6	19					0	0	1	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111795980	111795980	+	Missense_Mutation	SNP	G	G	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr3:111795980G>A	ENST00000452346.2	+	16	2216	c.2213G>A	c.(2212-2214)aGa>aAa	p.R738K	TMPRSS7_ENST00000419127.1_Missense_Mutation_p.R612K			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	738	Peptidase S1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						TGGGGGCGAAGACACGAAGCA	0.517000													13	52					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													3	61					0	0	1	0	0
TMEM57	55219	broad.mit.edu	37	1	25810628	25810628	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr1:25810628delG	ENST00000374343.4	+	7	1355	c.1176delG	c.(1174-1176)aafs	p.K392fs	TMEM57_ENST00000399763.3_Frame_Shift_Del_p.K34fs|TMEM57_ENST00000399766.3_Frame_Shift_Del_p.K165fs	NM_018202.4	NP_060672.2	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	392						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part				breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		ACATTAAAAAGTTAAAGGCTG	0.542													9	142	---	---	---	---					
RP11-343N15.1	0	broad.mit.edu	37	1	121137791	121137793	+	RNA	DEL	CCA	CCA	-	rs28552466	by1000genomes	TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr1:121137791_121137793delCCA	ENST00000437515.1	-	0	329																											ATTTCGCCCTCCACCGCCGCCGC	0.631													8	10	---	---	---	---					
AC007682.1	0	broad.mit.edu	37	2	51737733	51737734	+	RNA	INS	-	-	A	rs13423125	by1000genomes	TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr2:51737733_51737734insA	ENST00000440698.1	+	0	694																											CTCGGAAAAGGAAAAAAAAAAA	0.490													2	4	---	---	---	---					
HDAC2	3066	broad.mit.edu	37	6	114292109	114292110	+	In_Frame_Ins	INS	-	-	CTG			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr6:114292109_114292110insCTG	ENST00000398283.2	-	1	249_250	c.245_246insCAG	c.(244-246)aag>aCAGag	p.82_82K>TE	RP3-399L15.3_ENST00000436876.2_RNA|HDAC2_ENST00000368632.2_5'UTR|RP3-399L15.3_ENST00000520554.1_RNA|HDAC2_ENST00000519065.1_5'UTR|RP3-399L15.3_ENST00000519104.1_RNA|RP3-399L15.3_ENST00000449620.2_RNA	NM_001527.3	NP_001518.3	Q92769	HDAC2_HUMAN	histone deacetylase 2	0	Histone deacetylase.				blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			biliary_tract(1)|central_nervous_system(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	GGCTCCTCCTCctgctgctgct	0.688													5	2	---	---	---	---					
TRDN	10345	broad.mit.edu	37	6	123786032	123786033	+	Frame_Shift_Ins	INS	-	-	A			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr6:123786032_123786033insA	ENST00000546248.1	-	9	1022_1023	c.889_890insT	c.(889-891)ttafs	p.L297fs	RP11-532N4.2_ENST00000587106.1_RNA|RP11-532N4.2_ENST00000589182.1_RNA|TRDN_ENST00000398178.3_Intron|RP11-532N4.2_ENST00000418467.2_RNA|RP11-532N4.2_ENST00000434768.1_RNA|TRDN_ENST00000334268.4_Intron|RP11-532N4.2_ENST00000427828.1_RNA	NM_001256020.1	NP_001242949.1	Q13061	TRDN_HUMAN	triadin	0					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		AGATCTTTAAGAAAAAAAAAAG	0.386													3	6	---	---	---	---					
AGAP4	119016	broad.mit.edu	37	10	46342668	46342688	+	In_Frame_Del	DEL	GCTCCTGCCATCCTGTCCCCA	GCTCCTGCCATCCTGTCCCCA	-			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr10:46342668_46342688delGCTCCTGCCATCCTGTCCCCA	ENST00000448048.2	-	1	233_253	c.108_128delTGGGGACAGGATGGCAGGAGC	c.(106-129)gcg>gc	p.AGDRMAGA36del	AGAP4_ENST00000430779.2_5'UTR	NM_133446.2	NP_597703.2	Q96P64	AGAP4_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 4	36					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding	p.G37_A43delGDRMAGA(1)		central_nervous_system(1)|lung(1)|ovary(1)	3						AGCCATGGGCGCTCCTGCCATCCTGTCCCCAGCTCCTGCCT	0.588													4	8	---	---	---	---					
DERL2	51009	broad.mit.edu	37	17	5383387	5383387	+	Frame_Shift_Del	DEL	T	T	-			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr17:5383387delT	ENST00000158771.4	-	6	656	c.601delA	c.(601-603)cafs	p.T201fs	DERL2_ENST00000572834.1_3'UTR|DERL2_ENST00000570848.1_3'UTR	NM_016041.3	NP_057125.2	Q9GZP9	DERL2_HUMAN	derlin 2	201					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of cell growth|positive regulation of cell proliferation|retrograde protein transport, ER to cytosol	integral to endoplasmic reticulum membrane	protein binding			large_intestine(3)	3						ATAGATGGTGTTTTCAGAATT	0.398													28	80	---	---	---	---					
CPLX4	339302	broad.mit.edu	37	18	56985676	56985676	+	Frame_Shift_Del	DEL	T	T	-			TCGA-QU-A6IM-01A-11D-A31L-08	TCGA-QU-A6IM-10A-01D-A31J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c46bdf0-625f-4d00-ae75-b9e83d2fe3ea	84da4992-73f8-4179-bc14-13735496a930	g.chr18:56985676delT	ENST00000299721.3	-	1	205	c.19delA	c.(19-21)gtfs	p.S7fs	CPLX4_ENST00000587244.1_Frame_Shift_Del_p.S7fs	NM_181654.3	NP_857637.1	Q7Z7G2	CPLX4_HUMAN	complexin 4	7					exocytosis|neurotransmitter transport	cell junction|synapse	syntaxin binding			autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	16		Colorectal(73;0.175)				CTTATCATACTTTTCATAAGG	0.378													14	34	---	---	---	---