Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CPA4	51200	broad.mit.edu	37	7	129962465	129962465	+	Silent	SNP	G	G	A			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr7:129962465G>A	ENST00000222482.4	+	11	1243	c.1215G>A	c.(1213-1215)acG>acA	p.T405T	CPA4_ENST00000445470.2_Silent_p.T372T|CPA4_ENST00000493259.1_Silent_p.T301T	NM_016352.3	NP_057436.2	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4	405					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Melanoma(18;0.0435)					CAGAGGAGACGTGGCTGGGGC	0.522000													28	57					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													3	16					0	0	1	0	0
ACVRL1	94	broad.mit.edu	37	12	52312898	52312898	+	Splice_Site	SNP	C	C	T			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr12:52312898C>T	ENST00000550683.1	+	8	1519	c.1419_splice	c.e8+1	p.P473_splice	ACVRL1_ENST00000419526.2_Splice_Site_p.P285_splice|ACVRL1_ENST00000388922.4_Splice_Site_p.P459_splice	NM_001077401.1	NP_001070869.1	P37023	ACVL1_HUMAN	activin A receptor type II-like 1	459	Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	GCTGCAGACCCGGTGAGGCCT	0.587000													14	42					0	0	1	0	0
ATP2B3	492	broad.mit.edu	37	X	152826170	152826170	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chrX:152826170C>T	ENST00000370186.1	+	17	3160	c.2834C>T	c.(2833-2835)gCg>gTg	p.A945V	ATP2B3_ENST00000349466.2_Missense_Mutation_p.A959V|ATP2B3_ENST00000263519.4_Missense_Mutation_p.A959V|ATP2B3_ENST00000393842.1_Missense_Mutation_p.A945V|ATP2B3_ENST00000370181.2_Missense_Mutation_p.A945V|ATP2B3_ENST00000460549.1_3'UTR|ATP2B3_ENST00000359149.3_Missense_Mutation_p.A959V			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	959					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding	p.A959V(6)|p.A945V(2)		NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGGAGGAATGCGCCCCTGCAC	0.562000													3	35					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664115	22664115	+	RNA	SNP	A	A	T			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr22:22664115A>T	ENST00000426066.1	+	0	638					NR_027293.1																						TGTTTAATTCAGCCTTGGAAG	0.413000													3	48					0	0	1	0	0
SLC25A25	114789	broad.mit.edu	37	9	130868474	130868474	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr9:130868474G>A	ENST00000373066.5	+	8	1347	c.940G>A	c.(940-942)Gag>Aag	p.E314K	SLC25A25_ENST00000432073.2_Missense_Mutation_p.E302K|SLC25A25_ENST00000373068.2_Missense_Mutation_p.E316K|SLC25A25_ENST00000433501.1_Missense_Mutation_p.E179K|SLC25A25_ENST00000373069.5_Missense_Mutation_p.E328K|SLC25A25_ENST00000373064.5_Missense_Mutation_p.E282K	NM_001265614.2	NP_001252543.1	Q6KCM7	SCMC2_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25	282					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)	10						GAGGATTCACGAGAGGCTTGT	0.602000													12	114					0	0	1	0	0
KRT27	342574	broad.mit.edu	37	17	38935957	38935957	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr17:38935957C>T	ENST00000301656.3	-	4	881	c.841G>A	c.(841-843)Gaa>Aaa	p.E281K		NM_181537.3	NP_853515.2	Q7Z3Y8	K1C27_HUMAN	keratin 27	281	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(3)|skin(1)|stomach(1)	21		Breast(137;0.000812)				TTTACCTTTTCGTTGAACCAG	0.657000													7	22					0	0	1	0	0
POM121C	100101267	broad.mit.edu	37	7	75070281	75070281	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr7:75070281C>A	ENST00000453279.2	-	5	1042	c.178G>T	c.(178-180)Gtg>Ttg	p.V60L	POM121C_ENST00000257665.5_Missense_Mutation_p.V302L	NM_001099415.1	NP_001092885.1	A8CG34	P121C_HUMAN	POM121 transmembrane nucleoporin C	302	Required for targeting to the nucleus and nuclear pore complex.				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14						TCTTCCTCCACTGTCCTTTTC	0.473000													36	162					1.67211e-32	1.86883e-32	1	1	0
TUBB8P7	0	broad.mit.edu	37	16	90162620	90162620	+	RNA	SNP	T	T	G			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr16:90162620T>G	ENST00000564451.1	+	0	1973																											CTAGGTAAAGTGGGGAAGCAG	0.483000													4	122					0	0	1	0	0
COL18A1	80781	broad.mit.edu	37	21	46888241	46888241	+	Silent	SNP	C	C	T			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr21:46888241C>T	ENST00000359759.4	+	2	1458	c.1437C>T	c.(1435-1437)gtC>gtT	p.V479V	COL18A1_ENST00000355480.5_Silent_p.V244V|COL18A1_ENST00000400337.2_Silent_p.V64V			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	479	TSP N-terminal.				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		ACCCCGACGTCGGGCTGGCCT	0.627000													19	48					0	0	1	0	0
ABCA5	23461	broad.mit.edu	37	17	67246065	67246065	+	Silent	SNP	A	A	G			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr17:67246065A>G	ENST00000392676.3	-	37	4810	c.4746T>C	c.(4744-4746)tcT>tcC	p.S1582S	ABCA5_ENST00000392677.2_Silent_p.S1583S|ABCA5_ENST00000588877.1_Silent_p.S1582S			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	1582					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					GCTTAAAAAAAGATTGTGAAA	0.284000													9	33					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88583764	88583764	+	Missense_Mutation	SNP	C	C	G			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr4:88583764C>G	ENST00000339673.6	+	6	933	c.834C>G	c.(832-834)gaC>gaG	p.D278E	DMP1_ENST00000282479.7_Missense_Mutation_p.D262E|RP11-742B18.1_ENST00000507894.1_RNA|RP11-742B18.1_ENST00000506480.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	278					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		AGGAAGATGACAGAAGCGAGC	0.478000													8	14					0	0	1	0	0
CRTC1	23373	broad.mit.edu	37	19	18870928	18870928	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr19:18870928C>T	ENST00000338797.6	+	9	849	c.824C>T	c.(823-825)cCg>cTg	p.P275L	CRTC1_ENST00000594658.1_Missense_Mutation_p.P218L|CRTC1_ENST00000601916.1_Missense_Mutation_p.P184L|CRTC1_ENST00000321949.8_Missense_Mutation_p.P259L	NM_001098482.1	NP_001091952.1	Q6UUV9	CRTC1_HUMAN	CREB regulated transcription coactivator 1	259					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	19						TCCCCGCTCCCGACCCCGCTG	0.682000													15	38					0	0	1	0	0
ADCK5	203054	broad.mit.edu	37	8	145616370	145616370	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr8:145616370C>A	ENST00000308860.6	+	6	624	c.580C>A	c.(580-582)Ccc>Acc	p.P194T	ADCK5_ENST00000526231.2_3'UTR	NM_174922.3	NP_777582.3	Q3MIX3	ADCK5_HUMAN	aarF domain containing kinase 5	194	Protein kinase.					integral to membrane	protein serine/threonine kinase activity			endometrium(1)|lung(2)|prostate(2)|skin(1)|stomach(2)	8	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;8.96e-41)|Epithelial(56;4.08e-40)|all cancers(56;4.51e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CCAGGCCCTCCCCCACGAGCT	0.637000													4	29					0.00909568	0.009601	1	1	0
GRHL1	29841	broad.mit.edu	37	2	10136062	10136062	+	Missense_Mutation	SNP	T	T	G			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr2:10136062T>G	ENST00000324907.9	+	13	1691	c.1555T>G	c.(1555-1557)Tct>Gct	p.S519A	GRHL1_ENST00000480736.1_5'UTR|GRHL1_ENST00000324883.5_Missense_Mutation_p.S330A|GRHL1_ENST00000405379.2_Missense_Mutation_p.S519A	NM_198182.2	NP_937825.2	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1 (Drosophila)	519					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		TGTCCCTCCTTCTACCAAGCT	0.448000													43	141					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128481309	128481309	+	Silent	SNP	G	G	A			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr7:128481309G>A	ENST00000325888.8	+	12	2160	c.1899G>A	c.(1897-1899)acG>acA	p.T633T	FLNC_ENST00000346177.6_Silent_p.T633T	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	633					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						ACTGGCCCACGGAGCCTGGGG	0.622000													5	149					0	0	1	0	0
MSLN	10232	broad.mit.edu	37	16	814693	814693	+	Missense_Mutation	SNP	A	A	G			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr16:814693A>G	ENST00000566549.1	+	6	764	c.347A>G	c.(346-348)gAc>gGc	p.D116G	MSLN_ENST00000382862.3_Missense_Mutation_p.D116G|MSLN_ENST00000563941.1_Missense_Mutation_p.D116G|MSLN_ENST00000545450.2_Missense_Mutation_p.D116G			Q13421	MSLN_HUMAN	mesothelin	116					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				breast(2)|kidney(2)|lung(11)|pancreas(1)|prostate(1)|skin(3)	20		Hepatocellular(780;0.00335)				GAGGACCTGGACGCCCTCCCA	0.682000													41	131					0	0	1	0	0
KCNK16	83795	broad.mit.edu	37	6	39282878	39282878	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr6:39282878G>A	ENST00000373229.5	-	6	843	c.830C>T	c.(829-831)gCg>gTg	p.A277V	KCNK16_ENST00000425054.2_3'UTR|KCNK16_ENST00000507712.1_Missense_Mutation_p.A165V|KCNK16_ENST00000373227.4_Missense_Mutation_p.A230V	NM_032115.3	NP_115491.1	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	277						integral to membrane	potassium channel activity|voltage-gated ion channel activity			large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)	13						GCCTGGAGCCGCCTTGGCTCC	0.572000													4	90					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													7	41					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3094169	3094169	+	Splice_Site	SNP	G	G	C			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr18:3094169G>C	ENST00000356443.4	-	26	4196	c.3864_splice	c.e26+1	p.P1288_splice	MYOM1_ENST00000400569.3_Splice_Site_p.P1288_splice|MYOM1_ENST00000261606.7_Splice_Site_p.P1192_splice	NM_003803.3|NM_019856.1	NP_003794.3|NP_062830.1	P52179	MYOM1_HUMAN	myomesin 1	1288						striated muscle myosin thick filament	structural constituent of muscle	p.P1288R(1)		NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AAAACCTACCGGGCCTTCAAA	0.408000													4	53					0	0	1	0	0
SETD6	79918	broad.mit.edu	37	16	58552021	58552021	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr16:58552021C>A	ENST00000394266.4	+	7	708	c.652C>A	c.(652-654)Caa>Aaa	p.Q218K	SETD6_ENST00000418480.1_Intron|SETD6_ENST00000219315.4_Missense_Mutation_p.Q287K|SETD6_ENST00000310682.2_Missense_Mutation_p.Q263K			Q8TBK2	SETD6_HUMAN	SET domain containing 6	287	SET.				negative regulation of NF-kappaB transcription factor activity|peptidyl-lysine monomethylation|regulation of inflammatory response	nucleus	NF-kappaB binding|protein-lysine N-methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	7						CACTTATGGGCAAATGGCTAA	0.463000													4	82					0.150653	0.150653	1	1	0
FAM180A	389558	broad.mit.edu	37	7	135418752	135418752	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr7:135418752G>A	ENST00000338588.3	-	3	758	c.493C>T	c.(493-495)Cgc>Tgc	p.R165C	FAM180A_ENST00000415751.1_Missense_Mutation_p.R165C	NM_205855.3	NP_995327.1	Q6UWF9	F180A_HUMAN	family with sequence similarity 180, member A	165						extracellular region				endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)	14						TGTGAGGAGCGCATCAAGTCG	0.597000													4	13					0	0	1	0	0
PPP6R1	22870	broad.mit.edu	37	19	55748179	55748179	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr19:55748179T>C	ENST00000412770.2	-	17	2386	c.1820A>G	c.(1819-1821)aAc>aGc	p.N607S	PPP6R1_ENST00000587283.1_Missense_Mutation_p.N607S	NM_014931.3	NP_055746.3	Q9UPN7	PP6R1_HUMAN	protein phosphatase 6, regulatory subunit 1	607					regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding			breast(1)	1						CTCAAGTAGGTTGGCGTTGGG	0.612000													19	44					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90149293	90149293	+	Silent	SNP	G	G	A			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr5:90149293G>A	ENST00000405460.2	+	80	17493	c.17397G>A	c.(17395-17397)gaG>gaA	p.E5799E	GPR98_ENST00000425867.2_Silent_p.E1460E	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	5799					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGTTTACAGAGTATAGCAGCC	0.373000													3	17					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128642835	128642835	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr11:128642835T>C	ENST00000344954.6	+	4	833	c.445T>C	c.(445-447)Tac>Cac	p.Y149H	FLI1_ENST00000281428.8_Missense_Mutation_p.Y116H|FLI1_ENST00000525560.1_Intron|FLI1_ENST00000429175.2_Missense_Mutation_p.Y182H|FLI1_ENST00000534087.1_Missense_Mutation_p.Y149H			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	182	PNT.				hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		CACCACCCTCTACAACACGGA	0.532000			T	EWSR1	Ewing sarcoma								12	117					0	0	1	0	0
DHX30	22907	broad.mit.edu	37	3	47889821	47889821	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr3:47889821G>A	ENST00000446256.2	+	16	2893	c.2321G>A	c.(2320-2322)cGc>cAc	p.R774H	DHX30_ENST00000457607.1_Missense_Mutation_p.R841H|DHX30_ENST00000445061.1_Missense_Mutation_p.R813H|DHX30_ENST00000348968.4_Missense_Mutation_p.R785H	NM_014966.3	NP_055781.2	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 30	813	Helicase C-terminal.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(13)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	37				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		GAGATCCTGCGCACACCTCTT	0.657000													17	32					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71346978	71346978	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr4:71346978T>C	ENST00000413702.1	+	4	805	c.517T>C	c.(517-519)Tct>Cct	p.S173P	MUC7_ENST00000456088.1_Missense_Mutation_p.S173P|MUC7_ENST00000304887.5_Missense_Mutation_p.S173P|MUC7_ENST00000514512.1_3'UTR	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	173	Thr-rich.					extracellular region	protein binding	p.S173P(3)		central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			ACCCACACCTTCTGCAACTAC	0.522000													7	96					0	0	1	0	0
DPP4	1803	broad.mit.edu	37	2	162865117	162865118	+	Frame_Shift_Ins	INS	-	-	G			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr2:162865117_162865118insG	ENST00000360534.3	-	22	2501_2502	c.1941_1942insC	c.(1939-1944)ttagtgfs	p.LV647fs	DPP4_ENST00000491591.1_5'UTR	NM_001935.3	NP_001926.2	P27487	DPP4_HUMAN	dipeptidyl-peptidase 4	647					cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	48					Sitagliptin(DB01261)	ATTCCACACTTGAACACGCCAC	0.465													30	70	---	---	---	---					
EPM2AIP1	9852	broad.mit.edu	37	3	37032769	37032769	+	Frame_Shift_Del	DEL	T	T	-			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr3:37032769delT	ENST00000322716.5	-	1	2026	c.1800delA	c.(1798-1800)agfs	p.R600fs		NM_014805.3	NP_055620.1	Q7L775	EPMIP_HUMAN	EPM2A (laforin) interacting protein 1	600						endoplasmic reticulum				breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(12)|ovary(2)	27						CATTTCTTTCTCTCACAAGGT	0.388													42	132	---	---	---	---					
TNRC18	84629	broad.mit.edu	37	7	5401259	5401259	+	Frame_Shift_Del	DEL	G	G	-			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr7:5401259delG	ENST00000399537.4	-	14	4975	c.4627delC	c.(4627-4629)gcfs	p.R1543fs	TNRC18_ENST00000430969.1_Frame_Shift_Del_p.R1543fs			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1543							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CCTCTCTTGCGGGGGGGCGAC	0.692													2	4	---	---	---	---					
CTC-513N18.6	0	broad.mit.edu	37	19	20635102	20635102	+	RNA	DEL	T	T	-			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chr19:20635102delT	ENST00000598131.1	+	0	256																											CAGGTAGGTGTTTTTTTTGCT	0.418													2	4	---	---	---	---					
TXLNG2P	0	broad.mit.edu	37	Y	21758038	21758039	+	RNA	INS	-	-	A			TCGA-V1-A9OA-01A-11D-A41K-08	TCGA-V1-A9OA-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	47d4bed8-db46-45d2-8e56-de72205f011d	d84f00dc-8c0d-4a2a-99e3-836a59aba5b7	g.chrY:21758038_21758039insA	ENST00000253320.4	+	0	3119_3120							Q9BZA5	CY15A_HUMAN												haematopoietic_and_lymphoid_tissue(1)	1						CTACTTCTTGGAAAAAAAAAAA	0.376													4	3	---	---	---	---