Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KAL1	3730	broad.mit.edu	37	X	8536357	8536357	+	Nonsense_Mutation	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chrX:8536357G>A	ENST00000262648.3	-	8	1272	c.1123C>T	c.(1123-1125)Caa>Taa	p.Q375*		NM_000216.2	NP_000207.2	P23352	KALM_HUMAN	Kallmann syndrome 1 sequence	375	Fibronectin type-III 2.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(1)	32						GTTATGGCTTGCAATTCCACA	0.438000													13	19					0	0	1	0	0
ESPNP	0	broad.mit.edu	37	1	17017717	17017717	+	RNA	SNP	C	C	T	rs12561804	by1000genomes	TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr1:17017717C>T	ENST00000492551.1	-	0	2010					NR_026567.1																						GCTCACCTCTCTTCTTCCAGC	0.622000													5	24					0	0	1	0	0
PRC1	9055	broad.mit.edu	37	15	91513730	91513730	+	Silent	SNP	G	G	T			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr15:91513730G>T	ENST00000361188.5	-	12	2687	c.1476C>A	c.(1474-1476)acC>acA	p.T492T	PRC1_ENST00000442656.2_Silent_p.T451T|PRC1-AS1_ENST00000554388.1_RNA|PRC1_ENST00000361919.3_Silent_p.T492T|PRC1-AS1_ENST00000556200.1_RNA|PRC1_ENST00000394249.3_Silent_p.T492T			O43663	PRC1_HUMAN	protein regulator of cytokinesis 1	492	Unstructured, Arg/Lys rich.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(3)|prostate(1)|skin(2)	25	Lung NSC(78;0.0987)|all_lung(78;0.175)					CATTGGACATGGTGGTAGTGT	0.502000													3	53					0.150653	0.150653	1	1	0
ZNF423	23090	broad.mit.edu	37	16	49671795	49671795	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr16:49671795G>A	ENST00000561648.1	-	4	1321	c.1268C>T	c.(1267-1269)gCc>gTc	p.A423V	ZNF423_ENST00000562871.1_Missense_Mutation_p.A363V|ZNF423_ENST00000562520.1_Missense_Mutation_p.A363V|ZNF423_ENST00000262383.2_Missense_Mutation_p.A423V|ZNF423_ENST00000563137.2_Missense_Mutation_p.A363V|ZNF423_ENST00000567169.1_Missense_Mutation_p.A306V|ZNF423_ENST00000535559.1_Missense_Mutation_p.A306V	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	423					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CTCCAGCACGGCCAGGCTGTT	0.607000													4	76					0	0	1	0	0
TGOLN2	10618	broad.mit.edu	37	2	85554616	85554616	+	Missense_Mutation	SNP	G	G	C			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr2:85554616G>C	ENST00000377386.3	-	2	701	c.239C>G	c.(238-240)aCc>aGc	p.T80S	TGOLN2_ENST00000409232.3_Missense_Mutation_p.T80S|TGOLN2_ENST00000409015.1_Missense_Mutation_p.T80S|TGOLN2_ENST00000398263.2_Missense_Mutation_p.T80S|TGOLN2_ENST00000444342.2_Missense_Mutation_p.T80S|TGOLN2_ENST00000282120.2_Intron			O43493	TGON2_HUMAN	trans-golgi network protein 2	80	14 X 14 AA tandem repeats.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding										CTTGTTGGGGGTGTCTTCTGG	0.597000													6	414					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156592716	156592716	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr5:156592716C>A	ENST00000302938.4	-	1	559	c.464G>T	c.(463-465)tGt>tTt	p.C155F		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	155						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGAAGAGGGACACAACTGCAG	0.478000													38	63					1.60099e-16	1.8452e-16	1	1	0
UBBP4	0	broad.mit.edu	37	17	21731270	21731270	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr17:21731270T>C	ENST00000584755.1	+	2	969	c.572T>C	c.(571-573)aTc>aCc	p.I191T	UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000578713.1_Intron														p.I191T(3)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						ATCCCCCCGATCAGCAGAGGC	0.547000													4	73					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114251469	114251469	+	Nonsense_Mutation	SNP	C	C	T			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr4:114251469C>T	ENST00000357077.4	+	27	3021	c.2968C>T	c.(2968-2970)Cga>Tga	p.R990*	ANK2_ENST00000506722.1_Nonsense_Mutation_p.R981*|ANK2_ENST00000509550.1_Nonsense_Mutation_p.R199*|ANK2_ENST00000264366.6_Nonsense_Mutation_p.R990*|ANK2_ENST00000394537.3_Nonsense_Mutation_p.R990*	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	990	Interaction with SPTBN1.|ZU5.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAATGGGCTCCGAATCATTAT	0.473000													10	31					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72984599	72984599	+	Silent	SNP	G	G	C			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr16:72984599G>C	ENST00000268489.5	-	3	3657	c.2985C>G	c.(2983-2985)ctC>ctG	p.L995L	ZFHX3_ENST00000397992.5_Silent_p.L81L	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	995					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				AGTTGGCCTTGAGCTGGGTGT	0.612000													14	13					0	0	1	0	0
HAUS6	54801	broad.mit.edu	37	9	19063090	19063090	+	Missense_Mutation	SNP	A	A	T			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr9:19063090A>T	ENST00000380502.3	-	14	2012	c.1545T>A	c.(1543-1545)aaT>aaA	p.N515K	HAUS6_ENST00000380496.1_Missense_Mutation_p.N379K	NM_017645.3	NP_060115.3	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	515					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TACTCTCTGTATTCTTTGCAA	0.358000													51	78					0	0	1	0	0
KRT6A	3853	broad.mit.edu	37	12	52884407	52884407	+	Silent	SNP	A	A	G			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr12:52884407A>G	ENST00000330722.6	-	5	1091	c.1023T>C	c.(1021-1023)taT>taC	p.Y341Y		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	341	Coil 2.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		CAATCTCCTCATATTGGGCCT	0.577000													12	143					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175334155	175334155	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr1:175334155T>C	ENST00000367674.1	-	12	3286	c.2578A>G	c.(2578-2580)Atc>Gtc	p.I860V	TNR_ENST00000263525.2_Missense_Mutation_p.I860V	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	860	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					CCTGTGGTGATGGAGCCCACA	0.502000													21	29					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8196684	8196684	+	Missense_Mutation	SNP	A	A	T			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr19:8196684A>T	ENST00000600128.1	-	15	2158	c.1744T>A	c.(1744-1746)Tgc>Agc	p.C582S	FBN3_ENST00000270509.2_Missense_Mutation_p.C582S|FBN3_ENST00000601739.1_Missense_Mutation_p.C582S			Q75N90	FBN3_HUMAN	fibrillin 3	582	EGF-like 7; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CCGTTCACGCAGATGCCGGGC	0.672000													5	6					0	0	1	0	0
AP1B1	162	broad.mit.edu	37	22	29750667	29750667	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr22:29750667G>A	ENST00000357586.2	-	7	1096	c.910C>T	c.(910-912)Cgc>Tgc	p.R304C	AP1B1_ENST00000432560.2_Missense_Mutation_p.R304C|AP1B1_ENST00000405198.1_Missense_Mutation_p.R304C|AP1B1_ENST00000415447.1_Missense_Mutation_p.R304C|AP1B1_ENST00000402502.1_Missense_Mutation_p.R304C|AP1B1_ENST00000317368.7_Missense_Mutation_p.R304C|AP1B1_ENST00000356015.2_Missense_Mutation_p.R304C	NM_001127.3	NP_001118.3	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1, beta 1 subunit	304					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						TTGATGTTGCGCAGGGCCACA	0.592000													21	13					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92380805	92380805	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr13:92380805G>A	ENST00000377067.3	+	4	1412	c.1040G>A	c.(1039-1041)cGc>cAc	p.R347H	GPC5_ENST00000483422.1_3'UTR	NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	347						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding	p.R347L(2)|p.R347H(1)		NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				ATTTGTGGCCGCCCTGTAAGA	0.418000													36	50					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547141	132547141	+	Silent	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr12:132547141G>A	ENST00000333577.4	+	48	8446	c.8337G>A	c.(8335-8337)caG>caA	p.Q2779Q	EP400_ENST00000332482.4_Silent_p.Q2706Q|EP400_ENST00000389562.2_Silent_p.Q2742Q|EP400_ENST00000389561.2_Silent_p.Q2743Q|EP400_ENST00000330386.6_Silent_p.Q2662Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2779	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2742Q(2)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacagcagcagcagc	0.597000													3	29					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149492709	149492709	+	RNA	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr7:149492709G>A	ENST00000378016.2	+	0	6489							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GTCTACACTGGCATGACTATC	0.617000													4	147					0	0	1	0	0
ESPNP	0	broad.mit.edu	37	1	17017734	17017734	+	RNA	SNP	C	C	T	rs12561805	by1000genomes	TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr1:17017734C>T	ENST00000492551.1	-	0	1993					NR_026567.1																						CAGCTTCTTCCGCAGGAGGTC	0.647000													6	20					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52619638	52619638	+	Silent	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr10:52619638G>A	ENST00000282641.2	-	3	250	c.63C>T	c.(61-63)cgC>cgT	p.R21R	A1CF_ENST00000395495.1_Silent_p.R21R|A1CF_ENST00000373997.3_Silent_p.R21R|A1CF_ENST00000373995.3_5'UTR|A1CF_ENST00000395489.2_5'UTR|A1CF_ENST00000374001.1_Silent_p.R21R|A1CF_ENST00000373993.1_Silent_p.R21R	NM_138932.2	NP_620310.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	21					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						GGACCAGTGCGCGGAGGGCTG	0.483000													30	32					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000330386.6_Silent_p.Q2644Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													7	40					0	0	1	0	0
CCDC155	147872	broad.mit.edu	37	19	49910161	49910161	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr19:49910161G>A	ENST00000447857.3	+	10	1022	c.817G>A	c.(817-819)Gag>Aag	p.E273K		NM_144688.4	NP_653289.3	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	273						integral to membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	22						GCTGCTTGCCGAGCGGGATGG	0.488000													4	10					0	0	1	0	0
VAT1L	57687	broad.mit.edu	37	16	77859293	77859293	+	Silent	SNP	C	C	T			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr16:77859293C>T	ENST00000302536.2	+	3	667	c.514C>T	c.(514-516)Ctg>Ttg	p.L172L		NM_020927.1	NP_065978.1	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport 1-like	172							oxidoreductase activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(10)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24						CTATGTGATGCTGTTTGAAGT	0.527000													10	8					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158632635	158632635	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr1:158632635C>T	ENST00000368148.3	-	17	2501	c.2321G>A	c.(2320-2322)cGa>cAa	p.R774Q	SPTA1_ENST00000368147.3_Missense_Mutation_p.R774Q	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	774					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton	p.R774L(1)		NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AGCTTCAAATCGGCATACCAA	0.478000													26	36					0	0	1	0	0
ZNF730	100129543	broad.mit.edu	37	19	23328789	23328789	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr19:23328789G>A	ENST00000597761.2	+	4	1142	c.943G>A	c.(943-945)Gaa>Aaa	p.E315K		NM_001277403.1	NP_001264332.1			zinc finger protein 730											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						ATACAAATGCGAAAAATGTGG	0.358000													6	16					0	0	1	0	0
SCP2D1	140856	broad.mit.edu	37	20	18794834	18794834	+	Silent	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr20:18794834G>A	ENST00000377428.2	+	1	465	c.375G>A	c.(373-375)ccG>ccA	p.P125P	C20orf78_ENST00000278779.4_Intron	NM_178483.2	NP_848578.1			SCP2 sterol-binding domain containing 1																		AAATGAACCCGCAGAAGGCTT	0.498000													3	45					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35538216	35538216	+	Missense_Mutation	SNP	G	G	C			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr17:35538216G>C	ENST00000353139.5	-	40	5339	c.4858C>G	c.(4858-4860)Ctg>Gtg	p.L1620V	ACACA_ENST00000394406.2_Missense_Mutation_p.L1583V|ACACA_ENST00000360679.3_Missense_Mutation_p.L1525V|ACACA_ENST00000335166.5_Missense_Mutation_p.L1505V	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	1583					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TTTGATTGCAGCAGGTCTTTG	0.433000													48	83					0	0	1	0	0
GRAMD1A	57655	broad.mit.edu	37	19	35512475	35512475	+	Silent	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr19:35512475G>A	ENST00000599564.1	+	15	1877	c.1806G>A	c.(1804-1806)tcG>tcA	p.S602S	CTD-2527I21.14_ENST00000605640.1_RNA|GRAMD1A_ENST00000317991.5_Silent_p.S515S|GRAMD1A_ENST00000411896.2_Silent_p.S508S|GRAMD1A_ENST00000504615.2_Silent_p.S281S			Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A	515						integral to membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	19	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			AGAAGAACTCGTGGAGCGGCA	0.582000													26	41					0	0	1	0	0
SLC22A5	6584	broad.mit.edu	37	5	131722816	131722816	+	Silent	SNP	G	G	T			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr5:131722816G>T	ENST00000245407.3	+	5	1145	c.924G>T	c.(922-924)gtG>gtT	p.V308V	SLC22A5_ENST00000435065.2_Silent_p.V332V	NM_003060.3	NP_003051.1	O76082	S22A5_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 5	308					positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|stomach(1)	8		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GGATTGTTGTGCCTTCCACTA	0.557000											OREG0016767	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	189					1.76689e-08	1.90712e-08	1	1	0
OR10H5	284433	broad.mit.edu	37	19	15904883	15904883	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr19:15904883G>A	ENST00000308940.8	+	1	123	c.25G>A	c.(25-27)Gtg>Atg	p.V9M		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						CCACACCTCCGTGTCTGAATT	0.572000													39	51					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41323722	41323722	+	Silent	SNP	C	C	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr12:41323722C>A	ENST00000551295.2	+	7	738	c.621C>A	c.(619-621)ggC>ggA	p.G207G	CNTN1_ENST00000347616.1_Silent_p.G207G|CNTN1_ENST00000547849.1_Silent_p.G207G|CNTN1_ENST00000547702.1_Silent_p.G207G|CNTN1_ENST00000348761.2_Silent_p.G196G|CNTN1_ENST00000360099.3_Silent_p.G207G	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	207	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CCGACAAAGGCAATTATTCCT	0.368000													42	130					6.48837e-15	7.35348e-15	1	1	0
TPTE2P6	0	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr13:25161397C>G	ENST00000453498.1	+	0	921																											TGAAACATCTCTACAACTGGA	0.343000													4	54					0	0	1	0	0
EMILIN3	90187	broad.mit.edu	37	20	39991122	39991122	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr20:39991122G>A	ENST00000332312.3	-	4	1279	c.1087C>T	c.(1087-1089)Cgc>Tgc	p.R363C		NM_052846.1	NP_443078.1	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	363						proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				AGCTCCTGGCGCAGGGCCAGC	0.672000													4	19					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145359109	145359109	+	Missense_Mutation	SNP	T	T	A	rs3967942		TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr1:145359109T>A	ENST00000342960.5	+	72	9084	c.9049T>A	c.(9049-9051)Tgt>Agt	p.C3017S	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3017								p.C3017S(1)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TCTTGAACTGTGTGACTCATG	0.483000													4	74					0	0	1	0	0
CDK14	5218	broad.mit.edu	37	7	90356069	90356069	+	Missense_Mutation	SNP	G	G	T			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr7:90356069G>T	ENST00000406263.1	+	2	616	c.174G>T	c.(172-174)aaG>aaT	p.K58N	CDK14_ENST00000265741.3_Missense_Mutation_p.K86N|CDK14_ENST00000380050.3_Missense_Mutation_p.K104N|CDK14_ENST00000436577.2_Missense_Mutation_p.R7I			O94921	CDK14_HUMAN	cyclin-dependent kinase 14	104					cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(12)|ovary(1)|skin(4)	32						TTAACTTTAAGACCTCCTCCA	0.453000													22	43					1.10513e-12	1.21208e-12	1	1	0
DUS1L	64118	broad.mit.edu	37	17	80019841	80019841	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr17:80019841G>A	ENST00000354321.7	-	5	1014	c.529C>T	c.(529-531)Cgc>Tgc	p.R177C	DUS1L_ENST00000306796.5_Missense_Mutation_p.R177C			Q6P1R4	DUS1L_HUMAN	dihydrouridine synthase 1-like (S. cerevisiae)	177					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			breast(1)|endometrium(1)|lung(2)|ovary(1)|skin(1)	6	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			TCCTTGGTGCGTCCGTGCACC	0.667000													29	40					0	0	1	0	0
COL21A1	0	broad.mit.edu	37	6	55932100	55932100	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr6:55932100C>A	ENST00000244728.5	-	23	2517	c.2120G>T	c.(2119-2121)gGt>gTt	p.G707V	COL21A1_ENST00000370819.1_Missense_Mutation_p.G704V|COL21A1_ENST00000370808.2_Missense_Mutation_p.G107V|COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000535941.1_Missense_Mutation_p.G707V	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	707	Collagen-like 4.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TACCTGAATACCTTTTTCACC	0.294000													13	22					2.62699e-14	2.92845e-14	1	1	0
NCOR2	9612	broad.mit.edu	37	12	124856836	124856836	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr12:124856836C>T	ENST00000356219.3	-	21	2694	c.2539G>A	c.(2539-2541)Gcg>Acg	p.A847T	NCOR2_ENST00000429285.2_Missense_Mutation_p.A829T|NCOR2_ENST00000404621.1_Missense_Mutation_p.A829T|NCOR2_ENST00000405201.1_Missense_Mutation_p.A847T|NCOR2_ENST00000404121.2_Missense_Mutation_p.A400T|NCOR2_ENST00000397355.1_Missense_Mutation_p.A830T	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	847					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TCCTCAGCCGCGGGGGGCTTC	0.697000													8	22					0	0	1	0	0
CLPB	81570	broad.mit.edu	37	11	72006547	72006547	+	Missense_Mutation	SNP	G	G	A	rs149985372	byFrequency	TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr11:72006547G>A	ENST00000294053.3	-	13	1738	c.1565C>T	c.(1564-1566)gCc>gTc	p.A522V	CLPB_ENST00000437826.2_Missense_Mutation_p.A477V|CLPB_ENST00000538021.1_Missense_Mutation_p.A130V|CLPB_ENST00000340729.5_Missense_Mutation_p.A463V|CLPB_ENST00000543042.1_Missense_Mutation_p.A321V|CLPB_ENST00000538039.1_Missense_Mutation_p.A492V	NM_001258394.1|NM_030813.4	NP_001245323.1|NP_110440.1	Q9H078	CLPB_HUMAN	ClpB caseinolytic peptidase B homolog (E. coli)	522					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	19						CAGGTTTTCGGCAATACGGTT	0.602000													3	40					0	0	1	0	0
AQPEP	0	broad.mit.edu	37	5	115298662	115298662	+	Missense_Mutation	SNP	G	G	T			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr5:115298662G>T	ENST00000357872.4	+	1	472	c.348G>T	c.(346-348)agG>agT	p.R116S	AQPEP_ENST00000395528.2_5'UTR	NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN		116					proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding										CGCAGCTGAGGCCCGACGAGC	0.697000													23	38					6.12954e-19	7.18635e-19	1	1	0
MYO7B	4648	broad.mit.edu	37	2	128335755	128335755	+	Silent	SNP	C	C	T			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr2:128335755C>T	ENST00000389524.4	+	9	950	c.897C>T	c.(895-897)gcC>gcT	p.A299A	MYO7B_ENST00000428314.1_Silent_p.A299A|MYO7B_ENST00000409816.2_Silent_p.A299A			Q6PIF6	MYO7B_HUMAN	myosin VIIB	299	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		AGGACTACGCCCACATCCGCT	0.627000													5	14					0	0	1	0	0
NEU4	129807	broad.mit.edu	37	2	242757477	242757477	+	Nonsense_Mutation	SNP	T	T	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr2:242757477T>A	ENST00000391969.2	+	5	1269	c.558T>A	c.(556-558)tgT>tgA	p.C186*	NEU4_ENST00000405370.1_Nonsense_Mutation_p.C186*|NEU4_ENST00000404257.1_Nonsense_Mutation_p.C198*|NEU4_ENST00000325935.6_Nonsense_Mutation_p.C199*|NEU4_ENST00000407683.1_Nonsense_Mutation_p.C186*	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	186						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		GCCGAGAGTGTTTTGGCAAGA	0.677000													8	15					0	0	1	0	0
GTSF1L	149699	broad.mit.edu	37	20	42354963	42354963	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr20:42354963C>A	ENST00000373003.1	-	1	675	c.372G>T	c.(370-372)aaG>aaT	p.K124N	GTSF1L_ENST00000373005.2_Missense_Mutation_p.K99N	NM_001008901.1|NM_176791.3	NP_001008901.1|NP_789761.1	Q9H1H1	GTSFL_HUMAN	gametocyte specific factor 1-like	124							metal ion binding			endometrium(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CACAAACAACCTTTTGAGGAA	0.502000													45	60					3.43241e-23	4.09481e-23	1	1	0
NR4A1	0	broad.mit.edu	37	12	52448435	52448435	+	Missense_Mutation	SNP	T	T	G			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr12:52448435T>G	ENST00000545748.1	+	3	1480	c.485T>G	c.(484-486)gTg>gGg	p.V162G	NR4A1_ENST00000360284.3_Missense_Mutation_p.V121G|NR4A1_ENST00000394824.2_Missense_Mutation_p.V108G|NR4A1_ENST00000394825.1_Missense_Mutation_p.V108G|NR4A1_ENST00000550082.1_Missense_Mutation_p.V121G|NR4A1_ENST00000548232.1_Missense_Mutation_p.V108G|NR4A1_ENST00000547206.1_3'UTR|NR4A1_ENST00000243050.1_Missense_Mutation_p.V108G			P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	108					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)	16				BRCA - Breast invasive adenocarcinoma(357;0.0967)		GACTTCCAGGTGTACGGCTGC	0.672000													15	45					0	0	1	0	0
POU5F1B	5462	broad.mit.edu	37	8	128428597	128428597	+	Nonsense_Mutation	SNP	T	T	G			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr8:128428597T>G	ENST00000465342.2	+	2	1643	c.486T>G	c.(484-486)taT>taG	p.Y162*	CASC8_ENST00000501396.1_RNA|CASC8_ENST00000523825.1_RNA|POU5F1B_ENST00000391675.1_Nonsense_Mutation_p.Y162*|CASC8_ENST00000502082.1_RNA			Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	162	POU-specific.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|prostate(1)|urinary_tract(1)	3						CCCTGGGATATACACAGGCCG	0.517000													3	16					0	0	1	0	0
FKBP4	2288	broad.mit.edu	37	12	2909556	2909556	+	Splice_Site	SNP	A	A	G			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr12:2909556A>G	ENST00000001008.4	+	8	1033		c.e8-1		RP4-816N1.7_ENST00000547042.1_RNA|RP4-816N1.6_ENST00000547834.1_RNA	NM_002014.3	NP_002005.1	Q02790	FKBP4_HUMAN	FK506 binding protein 4, 59kDa						negative regulation of microtubule polymerization or depolymerization|negative regulation of neuron projection development|protein folding	axonal growth cone|cytosol|membrane|microtubule|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding, bridging			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(1)	14			OV - Ovarian serous cystadenocarcinoma(31;0.00105)		Dimethyl sulfoxide(DB01093)	CTCCCATTCCAGGAAGGTAAA	0.468000													13	16					0	0	1	0	0
AJ271736.10	0	broad.mit.edu	37	X	155252868	155252868	+	RNA	SNP	T	T	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chrX:155252868T>A	ENST00000285718.7	+	0	819				WASH6P_ENST00000461007.1_RNA														p.P304P(5)									TAGCCGAGCCTCTCAAGGCAG	0.632000													4	6					0	0	1	0	0
IGHV3-43	0	broad.mit.edu	37	14	106926482	106926482	+	RNA	SNP	T	T	C			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr14:106926482T>C	ENST00000434710.1	-	0	139																											CCAGCTGCACTTCACACTGGA	0.527000													4	170					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37792013	37792013	+	Missense_Mutation	SNP	C	C	G			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr3:37792013C>G	ENST00000264741.5	+	23	2750	c.2494C>G	c.(2494-2496)Cga>Gga	p.R832G	AC093415.2_ENST00000449586.1_RNA	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	832					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity	p.R832*(1)		breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TTTCCCTAATCGACTCTCATC	0.488000													23	50					0	0	1	0	0
RGL3	57139	broad.mit.edu	37	19	11516074	11516074	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr19:11516074G>A	ENST00000380456.3	-	8	1088	c.1025C>T	c.(1024-1026)tCc>tTc	p.S342F	RGL3_ENST00000393423.3_Missense_Mutation_p.S342F	NM_001035223.2|NM_001161616.1	NP_001030300.2|NP_001155088.1	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation stimulator-like 3	342	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				breast(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(1)|skin(1)	18						GGCGCGCAAGGAGGAGAAGTT	0.617000													4	2					0	0	1	0	0
SEMA6A	57556	broad.mit.edu	37	5	115783231	115783231	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr5:115783231G>A	ENST00000343348.6	-	19	2958	c.2171C>T	c.(2170-2172)aCg>aTg	p.T724M	SEMA6A_ENST00000510263.1_Missense_Mutation_p.T724M|SEMA6A_ENST00000503865.1_Missense_Mutation_p.T103M|SEMA6A_ENST00000282394.6_Missense_Mutation_p.T201M|SEMA6A_ENST00000257414.8_Missense_Mutation_p.T741M|SEMA6A_ENST00000513137.1_Missense_Mutation_p.T151M	NM_020796.3	NP_065847.1	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	724					apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		CATGAGTGGCGTGAGGATGGC	0.632000													5	199					0	0	1	0	0
SLC30A2	7780	broad.mit.edu	37	1	26371585	26371585	+	Silent	SNP	A	A	G			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr1:26371585A>G	ENST00000374278.3	-	2	390	c.174T>C	c.(172-174)ggT>ggC	p.G58G	SLC30A2_ENST00000498060.1_5'UTR|SLC30A2_ENST00000374276.3_Silent_p.G58G	NM_032513.3	NP_115902.1	Q9BRI3	ZNT2_HUMAN	solute carrier family 30 (zinc transporter), member 2	58					positive regulation of sequestering of zinc ion|zinc ion transport	integral to membrane|late endosome|lysosomal membrane	cation transmembrane transporter activity			cervix(1)|endometrium(2)|kidney(1)|lung(8)|stomach(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.09e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00614)|READ - Rectum adenocarcinoma(331;0.0649)		GACTGTCAGGACCCTTCTGAG	0.592000													35	70					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628296	29628296	+	Nonsense_Mutation	SNP	A	A	T			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr20:29628296A>T	ENST00000278882.3	+	6	678	c.298A>T	c.(298-300)Aaa>Taa	p.K100*	FRG1B_ENST00000358464.4_Nonsense_Mutation_p.K100*|FRG1B_ENST00000439954.2_Nonsense_Mutation_p.K105*																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						CATAGAAGCAAAAAGTAAAAC	0.363000													7	67					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000595295.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													3	10					0.115264	0.116984	1	1	0
TGOLN2	10618	broad.mit.edu	37	2	85554607	85554607	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr2:85554607T>C	ENST00000377386.3	-	2	710	c.248A>G	c.(247-249)aAg>aGg	p.K83R	TGOLN2_ENST00000409232.3_Missense_Mutation_p.K83R|TGOLN2_ENST00000409015.1_Missense_Mutation_p.K83R|TGOLN2_ENST00000398263.2_Missense_Mutation_p.K83R|TGOLN2_ENST00000444342.2_Missense_Mutation_p.K83R|TGOLN2_ENST00000282120.2_Intron			O43493	TGON2_HUMAN	trans-golgi network protein 2	83	14 X 14 AA tandem repeats.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding										CGCACCCGACTTGTTGGGGGT	0.602000													6	461					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111156017	111156017	+	Silent	SNP	C	C	A			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chrX:111156017C>A	ENST00000262839.2	-	3	1320	c.402G>T	c.(400-402)acG>acT	p.T134T		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	134					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						CAGAGAACTGCGTGTCCATCA	0.458000													5	28					3.59834e-05	3.76441e-05	1	1	0
IARS2	55699	broad.mit.edu	37	1	220300180	220300180	+	Missense_Mutation	SNP	T	T	G			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr1:220300180T>G	ENST00000366922.1	+	14	1947	c.1616T>G	c.(1615-1617)cTt>cGt	p.L539R	IARS2_ENST00000302637.5_Missense_Mutation_p.L611R			Q9NSE4	SYIM_HUMAN	isoleucyl-tRNA synthetase 2, mitochondrial	611					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			NS(1)|breast(1)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(17)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	TCTTATGTTCTTCCAGGTAAT	0.363000													37	28					0	0	1	0	0
C7orf55-LUC7L2	0	broad.mit.edu	37	7	139094365	139094366	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr7:139094365_139094366delAG	ENST00000354926.4	+	7	1098_1099	c.744_745delAG	c.(742-747)gaagfs	p.EE248fs	C7orf55-LUC7L2_ENST00000541170.3_Frame_Shift_Del_p.EE245fs|LUC7L2_ENST00000541515.3_Frame_Shift_Del_p.EE314fs|C7orf55-LUC7L2_ENST00000263545.6_Frame_Shift_Del_p.EE247fs	NM_016019.3	NP_057103.2																					AACGAAGAGAAGAGAGAGAGAG	0.391													3	3	---	---	---	---					
FAM83A	84985	broad.mit.edu	37	8	124219887	124219887	+	Frame_Shift_Del	DEL	C	C	-			TCGA-V1-A9OL-01A-11D-A41K-08	TCGA-V1-A9OL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10d212ad-7a3d-4bb9-849e-3bcf4fcdf741	8630a7bf-bde9-4726-ac4d-8641b8365de9	g.chr8:124219887delC	ENST00000518448.1	+	5	3278	c.1264delC	c.(1264-1266)cafs	p.P422fs	FAM83A_ENST00000546351.1_Intron|FAM83A_ENST00000536633.1_Intron|FAM83A_ENST00000318462.6_Frame_Shift_Del_p.P422fs|FAM83A_ENST00000276699.6_Intron|FAM83A_ENST00000522648.1_Intron			Q86UY5	FA83A_HUMAN	family with sequence similarity 83, member A	422										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(2)|skin(1)	17	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GAGGCTGACTCCAACCTGGAG	0.706													2	4	---	---	---	---