Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PRKDC	5591	broad.mit.edu	37	8	48690415	48690415	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr8:48690415C>A	ENST00000314191.2	-	85	11927	c.11871G>T	c.(11869-11871)ttG>ttT	p.L3957F	PRKDC_ENST00000338368.3_Missense_Mutation_p.L3926F|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	3958	PI3K/PI4K.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GAAAAGGCATCAACTCAGGGA	0.468000								Non-homologous end-joining					7	14					0.27861	0.28614	1	1	0
GLCE	26035	broad.mit.edu	37	15	69553493	69553493	+	Silent	SNP	A	A	T			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr15:69553493A>T	ENST00000261858.2	+	4	882	c.654A>T	c.(652-654)ggA>ggT	p.G218G	GLCE_ENST00000559500.1_3'UTR|GLCE_ENST00000559420.2_Silent_p.G154G	NM_015554.1	NP_056369.1	O94923	GLCE_HUMAN	glucuronic acid epimerase	218					heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	18						CACAGTATGGATTAAGTCATT	0.373000													17	78					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71946489	71946489	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr11:71946489C>T	ENST00000541756.1	+	23	2857	c.1927C>T	c.(1927-1929)Ctc>Ttc	p.L643F	INPPL1_ENST00000538751.1_Missense_Mutation_p.L643F|INPPL1_ENST00000298229.2_Missense_Mutation_p.L885F			O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	885					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						CCGTGAGCGGCTCTACGGTGG	0.617000													17	96					0	0	1	0	0
PQLC2	54896	broad.mit.edu	37	1	19653727	19653727	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr1:19653727C>T	ENST00000375153.3	+	7	1265	c.625C>T	c.(625-627)Cgg>Tgg	p.R209W	PQLC2_ENST00000400548.2_Missense_Mutation_p.R144W|PQLC2_ENST00000375155.3_Missense_Mutation_p.R209W	NM_001040125.1	NP_001035214.1	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2	209	PQ-loop 2.					integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGTTCCTCCGGAAGTCCAC	0.597000													7	49					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													5	40					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39781228	39781228	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr1:39781228C>T	ENST00000564288.1	+	27	4091	c.3314C>T	c.(3313-3315)gCa>gTa	p.A1105V	MACF1_ENST00000317713.7_Missense_Mutation_p.A1110V|MACF1_ENST00000372915.3_Missense_Mutation_p.A1110V|MACF1_ENST00000545844.1_Missense_Mutation_p.A1110V|MACF1_ENST00000539005.1_Missense_Mutation_p.A1110V|MACF1_ENST00000476350.1_3'UTR|MACF1_ENST00000567887.1_Missense_Mutation_p.A1142V|MACF1_ENST00000361689.2_Missense_Mutation_p.A1110V			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	1110					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GACTTGGATGCAGTTTCTATG	0.453000													20	97					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49420109	49420109	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr12:49420109G>A	ENST00000301067.7	-	48	15639	c.15640C>T	c.(15640-15642)Cgc>Tgc	p.R5214C		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D									p.R5214C(1)|p.R4944C(1)									CAATAGATGCGCGTGGCCTCG	0.577000													8	30					0	0	1	0	0
RPTOR	57521	broad.mit.edu	37	17	78831653	78831653	+	Missense_Mutation	SNP	C	C	G			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr17:78831653C>G	ENST00000306801.3	+	13	1824	c.1462C>G	c.(1462-1464)Cgg>Ggg	p.R488G	RPTOR_ENST00000537330.1_Missense_Mutation_p.R303G|RPTOR_ENST00000544334.2_Missense_Mutation_p.R488G|RPTOR_ENST00000575542.1_3'UTR	NM_020761.2	NP_065812.1	Q8N122	RPTOR_HUMAN	regulatory associated protein of MTOR, complex 1	488					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	44						CCGAGAGCTGCGGCCACTTCT	0.652000													5	30					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940373	22940373	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr19:22940373T>C	ENST00000397104.3	-	5	2064	c.2065A>G	c.(2065-2067)Aag>Gag	p.K689E	ZNF99_ENST00000596209.1_Missense_Mutation_p.K780E					zinc finger protein 99									p.K689E(3)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGAATTATCTTATGTTTTCTA	0.343000													4	63					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7177603	7177603	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr12:7177603G>A	ENST00000406697.1	+	15	2343	c.1715G>A	c.(1714-1716)cGa>cAa	p.R572Q	C1S_ENST00000328916.3_Missense_Mutation_p.R572Q|C1S_ENST00000402681.3_Missense_Mutation_p.R405Q|C1S_ENST00000360817.5_Missense_Mutation_p.R572Q			P09871	C1S_HUMAN	complement component 1, s subcomponent	572	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GGCTGGGGCCGAACAGAGAAG	0.537000													4	29					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49420108	49420108	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr12:49420108C>A	ENST00000301067.7	-	48	15640	c.15641G>T	c.(15640-15642)cGc>cTc	p.R5214L		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CCAATAGATGCGCGTGGCCTC	0.577000													9	30					7.48243e-07	8.61613e-07	1	1	0
MED15	51586	broad.mit.edu	37	22	20929420	20929420	+	Silent	SNP	C	C	G			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr22:20929420C>G	ENST00000263205.7	+	9	1242	c.1173C>G	c.(1171-1173)gcC>gcG	p.A391A	MED15_ENST00000382974.2_Intron|MED15_ENST00000425759.2_Intron|MED15_ENST00000406969.1_Intron|MED15_ENST00000542773.1_Intron|MED15_ENST00000292733.7_Intron|MED15_ENST00000541476.1_Intron|MED15_ENST00000478831.1_Intron	NM_001003891.1	NP_001003891.1	Q96RN5	MED15_HUMAN	mediator complex subunit 15	391	Pro-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	25	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			AAGCCTTGGCCCAAGGTGGGA	0.587000													6	141					0	0	1	0	0
OR11G2	390439	broad.mit.edu	37	14	20666367	20666367	+	Silent	SNP	C	C	A			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr14:20666367C>A	ENST00000357366.3	+	1	873	c.873C>A	c.(871-873)ggC>ggA	p.G291G		NM_001005503.1	NP_001005503.1	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G, member 2	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TGTTCTACGGCTCAGTACTGG	0.507000													4	123					0.150653	0.159023	1	1	0
TUBGCP5	114791	broad.mit.edu	37	15	22851079	22851079	+	Nonsense_Mutation	SNP	T	T	G			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr15:22851079T>G	ENST00000283645.4	+	11	1471	c.1341T>G	c.(1339-1341)taT>taG	p.Y447*	TUBGCP5_ENST00000559846.1_3'UTR|TUBGCP5_ENST00000453949.2_Nonsense_Mutation_p.Y447*	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	447					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		TTCTTGAATATGACAATGTTG	0.483000													9	60					0	0	1	0	0
KRTAP5-7	440050	broad.mit.edu	37	11	71238651	71238651	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr11:71238651G>A	ENST00000398536.4	+	1	339	c.305G>A	c.(304-306)tGc>tAc	p.C102Y		NM_001012503.1	NP_001012521.1	Q6L8G8	KRA57_HUMAN	keratin associated protein 5-7	102	7 X 4 AA repeats of C-C-X-P.					keratin filament				breast(1)|endometrium(1)|kidney(3)|lung(6)|ovary(1)	12						aagccctgctgctgctcctca	0.632000													16	193					0	0	1	0	0
DOCK1	1793	broad.mit.edu	37	10	129209120	129209120	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr10:129209120G>A	ENST00000280333.6	+	43	4406	c.4297G>A	c.(4297-4299)Gag>Aag	p.E1433K		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1433	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CAGGGTGAACGAGGTCCAGCG	0.428000													3	28					0	0	1	0	0
UBAP1	51271	broad.mit.edu	37	9	34249846	34249846	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr9:34249846C>A	ENST00000536252.1	+	6	1551	c.1153C>A	c.(1153-1155)Ctg>Atg	p.L385M	UBAP1_ENST00000297661.4_Missense_Mutation_p.L385M|UBAP1_ENST00000543944.1_Missense_Mutation_p.L421M|UBAP1_ENST00000540348.1_Missense_Mutation_p.L385M|UBAP1_ENST00000359544.2_Missense_Mutation_p.L385M|UBAP1_ENST00000545103.1_Missense_Mutation_p.L449M|UBAP1_ENST00000379186.4_Intron	NM_001171203.2	NP_001164674.1	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	385						cytoplasm				endometrium(4)|kidney(2)|lung(6)|upper_aerodigestive_tract(1)	13			LUSC - Lung squamous cell carcinoma(29;0.00272)			CTATTCTGAACTGCAGATGCT	0.527000													19	72					1.33834e-09	1.69523e-09	1	1	0
SNX13	23161	broad.mit.edu	37	7	17838696	17838696	+	Nonsense_Mutation	SNP	G	G	A			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr7:17838696G>A	ENST00000409389.1	-	23	2585	c.2413C>T	c.(2413-2415)Cga>Tga	p.R805*	SNX13_ENST00000428135.3_Nonsense_Mutation_p.R794*|SNX13_ENST00000496855.1_5'UTR			Q9Y5W8	SNX13_HUMAN	sorting nexin 13	805					cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(13)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(10;0.0261)|all_lung(11;0.0521)					ATATTCCTTCGCAACCACTGA	0.358000													6	53					0	0	1	0	0
RABGGTA	5875	broad.mit.edu	37	14	24734832	24734832	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr14:24734832C>T	ENST00000399409.3	-	16	2176	c.1693G>A	c.(1693-1695)Gtc>Atc	p.V565I	RABGGTA_ENST00000560777.1_Missense_Mutation_p.V174I|RABGGTA_ENST00000216840.6_Missense_Mutation_p.V565I	NM_004581.5	NP_004572.3	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase, alpha subunit	565					visual perception		Rab geranylgeranyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)	12				GBM - Glioblastoma multiforme(265;0.0184)		TAGGTGAGGACGCTGCTAACT	0.577000													3	21					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167553796	167553796	+	Nonsense_Mutation	SNP	C	C	A			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr5:167553796C>A	ENST00000519204.1	+	11	2002	c.1884C>A	c.(1882-1884)tgC>tgA	p.C628*	CTB-178M22.1_ENST00000517408.1_RNA|TENM2_ENST00000545108.1_Nonsense_Mutation_p.C749*|TENM2_ENST00000518659.1_Nonsense_Mutation_p.C749*|TENM2_ENST00000520394.1_Nonsense_Mutation_p.C517*|TENM2_ENST00000403607.2_Nonsense_Mutation_p.C582*					teneurin transmembrane protein 2																		ACGGCGTCTGCATCGGGGGAG	0.582000													3	18					0.115264	0.128824	1	1	0
NUDT12	83594	broad.mit.edu	37	5	102887965	102887965	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr5:102887965C>A	ENST00000230792.2	-	6	1327	c.1231G>T	c.(1231-1233)Gtt>Ttt	p.V411F	NUDT12_ENST00000507423.1_Missense_Mutation_p.V393F	NM_031438.2	NP_113626.1	Q9BQG2	NUD12_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 12	411	Nudix hydrolase.					nucleus|peroxisome	metal ion binding|NAD+ diphosphatase activity			endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|urinary_tract(1)	12		all_cancers(142;6.38e-08)|all_epithelial(76;1.99e-10)|Prostate(80;0.0138)|Lung NSC(167;0.0212)|Colorectal(57;0.0247)|all_lung(232;0.0283)|Ovarian(225;0.0423)		Epithelial(69;9.3e-13)|COAD - Colon adenocarcinoma(37;0.0221)		TTCTTGTCAACTTTAATTTCT	0.403000													3	34					1	1	1	1	0
ZNF232	7775	broad.mit.edu	37	17	5009416	5009416	+	Silent	SNP	G	G	A			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr17:5009416G>A	ENST00000250076.3	-	5	1692	c.1038C>T	c.(1036-1038)ctC>ctT	p.L346L	ZNF232_ENST00000416429.2_3'UTR|ZNF232_ENST00000575898.1_Silent_p.L337L	NM_014519.2	NP_055334.2	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	319					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|ovary(1)|prostate(2)	11						GATGCTGACCGAGGTTTGAGC	0.438000													5	133					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628283	29628283	+	Silent	SNP	G	G	C			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr20:29628283G>C	ENST00000278882.3	+	6	665	c.285G>C	c.(283-285)ggG>ggC	p.G95G	FRG1B_ENST00000358464.4_Silent_p.G95G|FRG1B_ENST00000439954.2_Silent_p.G100G														p.G95G(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGAAGCAGGGGACATAGAAG	0.378000													5	71					0	0	1	0	0
KLC4	89953	broad.mit.edu	37	6	43034071	43034071	+	Missense_Mutation	SNP	C	C	G			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr6:43034071C>G	ENST00000394056.2	+	6	1094	c.599C>G	c.(598-600)gCt>gGt	p.A200G	KLC4_ENST00000259708.3_Missense_Mutation_p.A218G|KLC4_ENST00000453940.2_Missense_Mutation_p.A123G|KLC4_ENST00000458460.2_Missense_Mutation_p.A200G|KLC4_ENST00000479388.1_Missense_Mutation_p.A200G|KLC4_ENST00000394058.1_Missense_Mutation_p.A200G|KLC4_ENST00000347162.5_Missense_Mutation_p.A200G			Q9NSK0	KLC4_HUMAN	kinesin light chain 4	200						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			endometrium(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(4)	23			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			GCTACAGCAGCTCAGCAGGGT	0.557000													3	74					0	0	1	0	0
KCNC4	3749	broad.mit.edu	37	1	110768691	110768691	+	Silent	SNP	G	G	A			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr1:110768691G>A	ENST00000369787.3	+	3	1737	c.1710G>A	c.(1708-1710)gaG>gaA	p.E570E	KCNC4_ENST00000412512.2_Intron|KCNC4_ENST00000413138.3_Silent_p.E570E|KCNC4_ENST00000438661.2_Silent_p.E570E	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	570					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		CCCCCGAGGAGCGCCGGGCCC	0.637000													9	47					0	0	1	0	0
SH2D2A	9047	broad.mit.edu	37	1	156777073	156777073	+	Missense_Mutation	SNP	T	T	G			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr1:156777073T>G	ENST00000392306.2	-	8	1236	c.1097A>C	c.(1096-1098)cAc>cCc	p.H366P	SH2D2A_ENST00000368198.3_Missense_Mutation_p.H338P|SH2D2A_ENST00000368199.3_Missense_Mutation_p.H356P	NM_001161441.1	NP_001154913.1	Q9NP31	SH22A_HUMAN	SH2 domain containing 2A	356	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|large_intestine(2)|lung(15)	18	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGGGGGCTGGTGGGGCAGGGG	0.597000													4	12					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72119078	72119078	+	Missense_Mutation	SNP	T	T	G			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr15:72119078T>G	ENST00000356056.5	-	42	7962	c.7490A>C	c.(7489-7491)aAg>aCg	p.K2497T	MYO9A_ENST00000424560.1_Missense_Mutation_p.K2568T|MYO9A_ENST00000564571.1_3'UTR|MYO9A_ENST00000444904.1_Missense_Mutation_p.K2478T	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	2497	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TTGTTTGCCCTTTTCCGGGTT	0.488000													14	109					0	0	1	0	0
FAM193B	54540	broad.mit.edu	37	5	176952083	176952083	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr5:176952083C>A	ENST00000329540.5	-	9	3106	c.277G>T	c.(277-279)Gtc>Ttc	p.V93F	FAM193B_ENST00000443375.2_Missense_Mutation_p.V434F|FAM193B_ENST00000514747.1_Missense_Mutation_p.V467F			Q6IPW0	Q6IPW0_HUMAN	family with sequence similarity 193, member B	143										kidney(1)|large_intestine(3)	4						AAGCTGTTGACCCGATCCAGT	0.567000													17	81					1.67942e-08	2.05864e-08	1	1	0
SPOP	8405	broad.mit.edu	37	17	47696424	47696424	+	Missense_Mutation	SNP	G	G	C			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr17:47696424G>C	ENST00000393331.3	-	7	869	c.399C>G	c.(397-399)ttC>ttG	p.F133L	SPOP_ENST00000347630.2_Missense_Mutation_p.F133L|SPOP_ENST00000503676.1_Missense_Mutation_p.F133L|SPOP_ENST00000504102.1_Missense_Mutation_p.F133L|SPOP_ENST00000393328.2_Missense_Mutation_p.F133L	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	133	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding	p.F133L(7)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						TGAATTTCTTGAATCCCCAGT	0.448000										Prostate(2;0.17)			19	120					0	0	1	0	0
TDRP	157695	broad.mit.edu	37	8	494659	494664	+	In_Frame_Del	DEL	GGCGGC	GGCGGC	-	rs71202629		TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr8:494659_494664delGGCGGC	ENST00000324079.6	-	1	334_339	c.94_99delGCCGCC	c.(94-99)del	p.AA32del	TDRP_ENST00000523656.1_In_Frame_Del_p.AA32del|TDRP_ENST00000427263.2_In_Frame_Del_p.AA32del					testis development related protein									p.A32_A33delAA(1)									CCTGCGCCTGggcggcggcggcggcg	0.782													3	4	---	---	---	---					
SKIDA1	387640	broad.mit.edu	37	10	21805466	21805467	+	In_Frame_Ins	INS	-	-	CCTCCT	rs138084841	by1000genomes	TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr10:21805466_21805467insCCTCCT	ENST00000449193.2	-	4	3537_3538	c.1285_1286insAGGAGG	c.(1285-1287)ggg>AGGAGGggg	p.428_429insRR	SKIDA1_ENST00000444772.3_In_Frame_Ins_p.349_350insRR	NM_207371.3	NP_997254.3			SKI/DACH domain containing 1									p.E428_G429insEE(2)									CCCGCTGCccccctcctcctcc	0.619													4	5	---	---	---	---					
OR8A1	390275	broad.mit.edu	37	11	124440636	124440636	+	Frame_Shift_Del	DEL	A	A	-			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr11:124440636delA	ENST00000284287.3	+	1	744	c.672delA	c.(670-672)atfs	p.I224fs		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	224					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		TCAACATCATAGTCACGAGCT	0.483													17	45	---	---	---	---					
ZNF93	81931	broad.mit.edu	37	19	20045269	20045270	+	Frame_Shift_Del	DEL	TT	TT	-	rs150239312	byFrequency	TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chr19:20045269_20045270delTT	ENST00000343769.5	+	4	1533_1534	c.1505_1506delTT	c.(1504-1506)afs	p.I502fs	AC007204.2_ENST00000592245.1_lincRNA	NM_031218.3	NP_112495.2	P35789	ZNF93_HUMAN	zinc finger protein 93	502						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	24						CATAAGAAAATTCATACTGGAG	0.347													19	98	---	---	---	---					
FAM120C	54954	broad.mit.edu	37	X	54209302	54209303	+	In_Frame_Ins	INS	-	-	GGCGGC			TCGA-V1-A9ZK-01A-11D-A41K-08	TCGA-V1-A9ZK-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3bf64ed-fc4c-48cf-bc4a-ade574edd020	e30e3059-aeee-4637-94d2-78520add854e	g.chrX:54209302_54209303insGGCGGC	ENST00000375180.2	-	1	385_386	c.329_330insGCCGCC	c.(328-330)ccc>cGCCGCCcc	p.109_110insRR	FAM120C_ENST00000477084.1_In_Frame_Ins_p.109_110insRR|FAM120C_ENST00000328235.4_In_Frame_Ins_p.109_110insRR	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	109										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						GCAGCTGAGGGGGCGGCGGCGG	0.748													5	4	---	---	---	---