Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLITRK5	26050	broad.mit.edu	37	13	88329124	88329124	+	Missense_Mutation	SNP	G	G	A	rs139493330		TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr13:88329124G>A	ENST00000325089.6	+	2	1700	c.1481G>A	c.(1480-1482)cGc>cAc	p.R494H	SLITRK5_ENST00000400028.3_Missense_Mutation_p.R253H	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	494						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					AATCTCATCCGCGAGATTCAG	0.542000													8	96					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40716261	40716261	+	Missense_Mutation	SNP	G	G	A			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr12:40716261G>A	ENST00000298910.7	+	37	5516	c.5458G>A	c.(5458-5460)Gaa>Aaa	p.E1820K		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1820					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TAATGATGGTGAAGAACATCA	0.348000													33	50					0	0	1	0	0
KLHL15	80311	broad.mit.edu	37	X	24006924	24006924	+	Missense_Mutation	SNP	A	A	G			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chrX:24006924A>G	ENST00000328046.8	-	4	1184	c.929T>C	c.(928-930)cTa>cCa	p.L310P		NM_030624.2	NP_085127.2	Q96M94	KLH15_HUMAN	kelch-like family member 15	310										autonomic_ganglia(1)|breast(1)|endometrium(8)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)	22						TGGGCCTTCTAGCTCCCACCA	0.463000													3	55					0	0	1	0	0
STOX2	56977	broad.mit.edu	37	4	184930356	184930356	+	Missense_Mutation	SNP	C	C	T			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr4:184930356C>T	ENST00000308497.4	+	3	1800	c.365C>T	c.(364-366)aCg>aTg	p.T122M	STOX2_ENST00000438269.1_Missense_Mutation_p.T122M	NM_020225.1	NP_064610.1	Q9P2F5	STOX2_HUMAN	storkhead box 2	122					embryo development|maternal placenta development					breast(1)|endometrium(7)|lung(6)	14		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		ACGCTGAACACGCTGGTACGG	0.438000													4	28					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64601218	64601218	+	Missense_Mutation	SNP	G	G	A			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr11:64601218G>A	ENST00000342711.5	-	22	2556	c.2557C>T	c.(2557-2559)Cgc>Tgc	p.R853C		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	853					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						ACCCCCATGCGCAGGCTGCGT	0.687000													16	39					0	0	1	0	0
MC4R	4160	broad.mit.edu	37	18	58039090	58039090	+	Missense_Mutation	SNP	G	G	A	rs13447332		TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr18:58039090G>A	ENST00000299766.3	-	1	911	c.493C>T	c.(493-495)Cgg>Tgg	p.R165W		NM_005912.2	NP_005903.2	P32245	MC4R_HUMAN	melanocortin 4 receptor	165			R -> Q (in obesity; shows a partial cAMP response to alpha-MSH; dbSNP:rs13447332).|R -> W (in obesity; dbSNP:rs13447332).		feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(73;0.0946)				ATCCCAACCCGCTTAACTGTC	0.433000													42	15					0	0	1	0	0
AHR	196	broad.mit.edu	37	7	17379808	17379808	+	Missense_Mutation	SNP	C	C	G			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr7:17379808C>G	ENST00000242057.4	+	10	3002	c.2359C>G	c.(2359-2361)Cag>Gag	p.Q787E		NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	787					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					GGGTCAGATGCAGTACAATCC	0.448000													33	48					0	0	1	0	0
KCNK17	89822	broad.mit.edu	37	6	39278711	39278711	+	Missense_Mutation	SNP	C	C	T			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr6:39278711C>T	ENST00000453413.2	-	2	450	c.310G>A	c.(310-312)Gtg>Atg	p.V104M	KCNK17_ENST00000373231.4_Missense_Mutation_p.V104M	NM_001135111.1	NP_001128583.1	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	104						integral to membrane	potassium channel activity|voltage-gated ion channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(2)	14						AAGGAGCCCACGAGCTCCCAG	0.607000													23	41					0	0	1	0	0
AURKAIP1	54998	broad.mit.edu	37	1	1309670	1309670	+	Missense_Mutation	SNP	A	A	C			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr1:1309670A>C	ENST00000338370.3	-	2	608	c.208T>G	c.(208-210)Tcc>Gcc	p.S70A	AURKAIP1_ENST00000321751.5_Missense_Mutation_p.S70A|AURKAIP1_ENST00000378853.3_Missense_Mutation_p.S70A|AURKAIP1_ENST00000489799.1_5'UTR|AURKAIP1_ENST00000338338.5_Missense_Mutation_p.S70A			Q9NWT8	AKIP_HUMAN	aurora kinase A interacting protein 1	70					negative regulation of mitosis|positive regulation of proteolysis	mitochondrion|nucleus	protein binding			kidney(1)|lung(2)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.82e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGGCTGACGGACATCTTCCTG	0.677000													6	29					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108175727	108175727	+	Missense_Mutation	SNP	A	A	G			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr3:108175727A>G	ENST00000273353.3	-	20	2140	c.2084T>C	c.(2083-2085)aTa>aCa	p.I695T	MYH15_ENST00000495753.2_5'UTR	NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	695	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						AGGGTCCAGTATACCTGGAAA	0.418000													55	73					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284523	52284523	+	Missense_Mutation	SNP	G	G	C			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr12:52284523G>C	ENST00000301190.6	+	5	1020	c.793G>C	c.(793-795)Gcc>Ccc	p.A265P	ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000538991.1_Missense_Mutation_p.A71P|ANKRD33_ENST00000340970.4_Missense_Mutation_p.A140P	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	140										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		CGAGTGGCCGGCCTTGTCCGG	0.667000													5	11					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92534829	92534829	+	Missense_Mutation	SNP	G	G	A			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr11:92534829G>A	ENST00000298047.6	+	9	8667	c.8650G>A	c.(8650-8652)Gag>Aag	p.E2884K	FAT3_ENST00000525166.1_Missense_Mutation_p.E2734K|FAT3_ENST00000409404.2_Missense_Mutation_p.E2884K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2884	Cadherin 26.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.E2884K(1)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCTAGATCACGAGACAGACCC	0.512000										TCGA Ovarian(4;0.039)			6	40					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27842018	27842018	+	Missense_Mutation	SNP	T	T	A			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr12:27842018T>A	ENST00000318304.8	+	26	2868	c.2585T>A	c.(2584-2586)cTg>cAg	p.L862Q	PPFIBP1_ENST00000537927.1_Missense_Mutation_p.L709Q|PPFIBP1_ENST00000228425.6_Missense_Mutation_p.L856Q|PPFIBP1_ENST00000542629.1_Missense_Mutation_p.L831Q	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193.2	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	862	SAM 3.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					AAGACTTTGCTGCGAAGACAT	0.433000													65	96					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73678510	73678510	+	Missense_Mutation	SNP	C	C	T			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr2:73678510C>T	ENST00000264448.6	+	8	4964	c.4853C>T	c.(4852-4854)gCa>gTa	p.A1618V	ALMS1_ENST00000377715.1_Missense_Mutation_p.A1618V|ALMS1_ENST00000409009.1_Missense_Mutation_p.A1576V	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1618	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						GGTTCCAGTGCACTTGGAGAG	0.473000													14	93					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152751620	152751620	+	Silent	SNP	T	T	C			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr6:152751620T>C	ENST00000367255.5	-	35	5287	c.4686A>G	c.(4684-4686)agA>agG	p.R1562R	SYNE1_ENST00000265368.4_Silent_p.R1562R|SYNE1_ENST00000448038.1_Silent_p.R1569R|SYNE1_ENST00000423061.1_Silent_p.R1569R|SYNE1_ENST00000341594.5_Silent_p.R1632R|SYNE1_ENST00000367253.4_Silent_p.R1562R	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1562					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCTTACCTTTCTAAGGTTCT	0.368000										HNSCC(10;0.0054)			39	52					0	0	1	0	0
GTPBP3	84705	broad.mit.edu	37	19	17452312	17452312	+	Missense_Mutation	SNP	C	C	G			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr19:17452312C>G	ENST00000324894.8	+	9	1347	c.1279C>G	c.(1279-1281)Ccg>Gcg	p.P427A	GTPBP3_ENST00000600625.1_Missense_Mutation_p.P406A|GTPBP3_ENST00000598038.1_3'UTR|GTPBP3_ENST00000361619.5_Missense_Mutation_p.P449A|GTPBP3_ENST00000358792.7_Missense_Mutation_p.P459A	NM_032620.3|NM_133644.3	NP_116009.2|NP_598399.2	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial)	427					tRNA modification	mitochondrion	GTP binding|GTPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	18						CACAGATCCCCCGCTGCTGAC	0.597000													23	66					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105418145	105418145	+	Missense_Mutation	SNP	G	G	A			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr14:105418145G>A	ENST00000333244.5	-	7	3762	c.3643C>T	c.(3643-3645)Ccc>Tcc	p.P1215S	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1215						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCGGAAGGGGGCTGAATGCTG	0.647000													3	1					0	0	1	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28306854	28306854	+	Silent	SNP	C	C	T			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr21:28306854C>T	ENST00000284987.5	-	4	1741	c.1620G>A	c.(1618-1620)acG>acA	p.T540T	AP001601.2_ENST00000426771.1_RNA	NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	540	Disintegrin.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						TTCCACAAGGCGTCCCTTCCA	0.522000													17	59					0	0	1	0	0
TAAR6	319100	broad.mit.edu	37	6	132891554	132891554	+	Missense_Mutation	SNP	C	C	T			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr6:132891554C>T	ENST00000275198.1	+	1	94	c.94C>T	c.(94-96)Cgg>Tgg	p.R32W		NM_175067.1	NP_778237.1	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	32						plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(19)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		GCCGGGATCCCGGGTGATTCT	0.532000													22	105					0	0	1	0	0
LARP1	23367	broad.mit.edu	37	5	154173201	154173201	+	Missense_Mutation	SNP	A	A	C			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr5:154173201A>C	ENST00000336314.4	+	5	579	c.555A>C	c.(553-555)gaA>gaC	p.E185D		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	262							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TGAAGCCTGAAGTGCCCAGAG	0.527000													65	94					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180030327	180030327	+	Silent	SNP	C	C	T			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr5:180030327C>T	ENST00000261937.6	-	30	4035	c.3957G>A	c.(3955-3957)cgG>cgA	p.R1319R		NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	0					positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CAGGCCGCCGCCGCCTCCCTT	0.627000													10	7					0	0	1	0	0
ABCB9	23457	broad.mit.edu	37	12	123419855	123419855	+	Missense_Mutation	SNP	C	C	T	rs147328787		TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr12:123419855C>T	ENST00000542678.1	-	10	4705	c.1867G>A	c.(1867-1869)Ggc>Agc	p.G623S	ABCB9_ENST00000344275.7_Missense_Mutation_p.G623S|ABCB9_ENST00000392439.3_Missense_Mutation_p.G623S|ABCB9_ENST00000280560.8_Missense_Mutation_p.G623S|ABCB9_ENST00000346530.5_Missense_Mutation_p.G580S|ABCB9_ENST00000442028.2_Missense_Mutation_p.G623S|ABCB9_ENST00000442833.2_Missense_Mutation_p.G623S|ABCB9_ENST00000540285.1_Missense_Mutation_p.G560S			Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 9	623	ABC transporter.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		ATGATGAAGCCGTGGGCATTG	0.627000													14	22					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65425585	65425585	+	Silent	SNP	C	C	T			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr3:65425585C>T	ENST00000330909.8	-	9	1238	c.1239G>A	c.(1237-1239)caG>caA	p.Q413Q	MAGI1_ENST00000483466.1_Silent_p.Q413Q|MAGI1_ENST00000497477.2_Silent_p.Q413Q|MAGI1_ENST00000402939.2_Silent_p.Q413Q|MAGI1_ENST00000470990.1_5'UTR	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	413	Poly-Gln.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		gctgctgctgctgctgttgct	0.537000											OREG0015658	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	110					0	0	1	0	0
HIST1H2BL	8340	broad.mit.edu	37	6	27775389	27775389	+	Missense_Mutation	SNP	A	A	T			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr6:27775389A>T	ENST00000377401.2	-	1	320	c.296T>A	c.(295-297)gTg>gAg	p.V99E		NM_003519.3	NP_003510.1	Q99880	H2B1L_HUMAN	histone cluster 1, H2bl	99					nucleosome assembly	nucleosome|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	12						CAGCAGGCGCACGGCGGTCTG	0.617000													41	74					0	0	1	0	0
ATP2A1	487	broad.mit.edu	37	16	28898525	28898525	+	Missense_Mutation	SNP	T	T	C			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr16:28898525T>C	ENST00000395503.4	+	7	744	c.560T>C	c.(559-561)gTc>gCc	p.V187A	ATP2A1_ENST00000536376.1_Missense_Mutation_p.V62A|ATP2A1_ENST00000357084.3_Missense_Mutation_p.V187A	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	187					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						TCTGTATCTGTCATCAAACAC	0.562000													10	76					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48611982	48611982	+	Splice_Site	SNP	C	C	T			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr3:48611982C>T	ENST00000328333.8	-	78	6502	c.6393_splice	c.e78-1	p.G2132_splice	COL7A1_ENST00000454817.1_Splice_Site_p.G2100_splice	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2132	Triple-helical region.		G -> D (in RDEB).		cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCCTGGCACACCCTGAAGGCA	0.627000													9	27					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4007037	4007037	+	Missense_Mutation	SNP	C	C	T			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr7:4007037C>T	ENST00000404826.2	+	10	1656	c.1517C>T	c.(1516-1518)gCt>gTt	p.A506V	SDK1_ENST00000389531.3_Missense_Mutation_p.A506V	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	506	Ig-like C2-type 5.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GTGTCCGGGGCTCCCAAACCC	0.562000													10	58					0	0	1	0	0
HUNK	30811	broad.mit.edu	37	21	33318387	33318387	+	Missense_Mutation	SNP	C	C	T			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr21:33318387C>T	ENST00000270112.2	+	4	1010	c.650C>T	c.(649-651)tCg>tTg	p.S217L		NM_014586.1	NP_055401.1	P57058	HUNK_HUMAN	hormonally up-regulated Neu-associated kinase	217	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(2)|stomach(1)	30						CTGGGTTACTCGGATCCGTTC	0.522000													53	99					0	0	1	0	0
ZNF445	353274	broad.mit.edu	37	3	44488987	44488987	+	Missense_Mutation	SNP	C	C	A			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr3:44488987C>A	ENST00000425708.2	-	7	2517	c.2176G>T	c.(2176-2178)Gtt>Ttt	p.V726F	ZNF445_ENST00000396077.2_Missense_Mutation_p.V726F			P59923	ZN445_HUMAN	zinc finger protein 445	726					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|skin(3)	31				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		TTCTTATGAACAATAAAGGCT	0.458000													52	117					9.45407e-15	9.45407e-15	1	1	0
SLC12A2	6558	broad.mit.edu	37	5	127516605	127516605	+	Missense_Mutation	SNP	C	C	T			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr5:127516605C>T	ENST00000262461.2	+	23	3320	c.3131C>T	c.(3130-3132)aCg>aTg	p.T1044M	SLC12A2_ENST00000507791.1_3'UTR|SLC12A2_ENST00000343225.4_Missense_Mutation_p.T1028M	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	1044					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TACCTTCTGACGACCAAGAAA	0.318000													39	72					0	0	1	0	0
SERPINF2	5345	broad.mit.edu	37	17	1649162	1649162	+	Missense_Mutation	SNP	C	C	T			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr17:1649162C>T	ENST00000324015.3	+	5	403	c.326C>T	c.(325-327)tCa>tTa	p.S109L	SERPINF2_ENST00000450523.2_Intron|SERPINF2_ENST00000382061.4_Missense_Mutation_p.S109L	NM_000934.3	NP_000925.2	P08697	A2AP_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	109					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	CTCATCCTGTCACCCCTGAGT	0.627000													40	80					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157668405	157668405	+	Missense_Mutation	SNP	C	C	G			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr1:157668405C>G	ENST00000368184.3	-	4	358	c.67G>C	c.(67-69)Gct>Cct	p.A23P	FCRL3_ENST00000368186.5_Missense_Mutation_p.A23P	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	23	Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					AGAAGTACAGCTTTTGGGGCC	0.527000													11	53					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179592369	179592369	+	Missense_Mutation	SNP	A	A	G			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr2:179592369A>G	ENST00000589042.1	-	68	20160	c.19936T>C	c.(19936-19938)Tgc>Cgc	p.C6646R	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.C5402R|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.C6329R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6329	Ig-like 48.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTAACATGGCAAGTATACTGT	0.423000													70	136					0	0	1	0	0
METTL13	51603	broad.mit.edu	37	1	171756946	171756946	+	Silent	SNP	C	C	T			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr1:171756946C>T	ENST00000361735.3	+	4	1451	c.1185C>T	c.(1183-1185)agC>agT	p.S395S	METTL13_ENST00000362019.3_Silent_p.S309S|METTL13_ENST00000458517.1_Silent_p.S394S|METTL13_ENST00000367737.5_Silent_p.S239S	NM_015935.4	NP_057019.3	Q8N6R0	MTL13_HUMAN	methyltransferase like 13	395							methyltransferase activity|protein binding			breast(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(8)|lung(17)|stomach(3)	41						GCCCCTTGAGCGGTGACTATG	0.547000													13	15					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57175802	57175802	+	Silent	SNP	G	G	A			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr19:57175802G>A	ENST00000537055.2	-	2	996	c.765C>T	c.(763-765)tgC>tgT	p.C255C		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						AGGCCTTGGCGCACGCGGAGC	0.682000													22	20					0	0	1	0	0
OR8D4	338662	broad.mit.edu	37	11	123777934	123777934	+	Missense_Mutation	SNP	A	A	T			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr11:123777934A>T	ENST00000321355.2	+	1	826	c.796A>T	c.(796-798)Agt>Tgt	p.S266C		NM_001005197.1	NP_001005197.1	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D, member 4	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|lung(16)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		TGCTTCTAGCAGTTCACTCAC	0.428000													13	95					0	0	1	0	0
CYP2D7P1	0	broad.mit.edu	37	22	42538870	42538870	+	RNA	SNP	A	A	C	rs2982057	by1000genomes	TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr22:42538870A>C	ENST00000358097.4	-	0	449				CYP2D7P1_ENST00000424775.1_RNA|CYP2D7P1_ENST00000433992.1_RNA																endometrium(1)	1						CCATAGCGCGACAGGAACACC	0.687000													3	29					0	0	1	0	0
SEMA7A	8482	broad.mit.edu	37	15	74703250	74703250	+	Silent	SNP	G	G	A			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr15:74703250G>A	ENST00000261918.4	-	14	2264	c.1716C>T	c.(1714-1716)caC>caT	p.H572H	SEMA7A_ENST00000542748.1_Silent_p.H407H|SEMA7A_ENST00000543145.2_Silent_p.H558H	NM_003612.3	NP_003603.1	O75326	SEM7A_HUMAN	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	572	Ig-like C2-type.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	30						AGTAGGTGGCGTGGCGGGATT	0.622000													41	70					0	0	1	0	0
TMEM257	9142	broad.mit.edu	37	X	144909435	144909435	+	Silent	SNP	G	G	A			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chrX:144909435G>A	ENST00000408967.2	+	1	508	c.240G>A	c.(238-240)acG>acA	p.T80T		NM_004709.2	NP_004700.1			transmembrane protein 257									p.T80T(1)									GCTTTAAGACGTATGAGCATC	0.398000													3	32					0	0	1	0	0
AASDH	132949	broad.mit.edu	37	4	57216169	57216171	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr4:57216169_57216171delAAG	ENST00000205214.6	-	11	1926_1928	c.1746_1748delCTT	c.(1744-1749)tta>tt	p.FL582del	AASDH_ENST00000434343.2_In_Frame_Del_p.FL97del|AASDH_ENST00000451613.1_In_Frame_Del_p.FL582del|AASDH_ENST00000502617.1_In_Frame_Del_p.FL582del|AASDH_ENST00000513376.1_In_Frame_Del_p.FL482del|AASDH_ENST00000602986.1_In_Frame_Del_p.FL429del	NM_181806.2	NP_861522.2	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	582	Acyl carrier.				fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	40	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				ACCACTATTTAAGAAGAGTGACT	0.414													14	26	---	---	---	---					
STRC	161497	broad.mit.edu	37	15	43910307	43910307	+	Frame_Shift_Del	DEL	G	G	-			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr15:43910307delG	ENST00000450892.2	-	2	389	c.312delC	c.(310-312)ccfs	p.P104fs	STRC_ENST00000541030.1_5'UTR	NM_153700.2	NP_714544.1	Q7RTU9	STRC_HUMAN	stereocilin	104					sensory perception of sound	cell surface				skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GCTCCCAGTCGGGGCTACCTC	0.622													2	4	---	---	---	---					
HIRA	7290	broad.mit.edu	37	22	19365430	19365430	+	Frame_Shift_Del	DEL	G	G	-			TCGA-XJ-A83F-01A-11D-A34U-08	TCGA-XJ-A83F-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aaa16e66-2563-4c7c-8209-3e501185226e	d7ad26f0-ee2d-4a35-9f25-c860af727cbd	g.chr22:19365430delG	ENST00000263208.5	-	14	1831	c.1575delC	c.(1573-1575)gcfs	p.A525fs	HIRA_ENST00000340170.4_Frame_Shift_Del_p.A525fs|HIRA_ENST00000541063.1_Frame_Shift_Del_p.A481fs|HIRA_ENST00000546308.1_Frame_Shift_Del_p.A481fs	NM_003325.3	NP_003316.3	P54198	HIRA_HUMAN	histone cell cycle regulator	525	Interaction with CCNA1.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)|prostate(1)|skin(1)	37	Colorectal(54;0.0993)					GTCTGGCACTGGCAGCCACCA	0.547													53	97	---	---	---	---