Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SORCS3	22986	broad.mit.edu	37	10	107022173	107022173	+	Silent	SNP	C	C	T			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr10:107022173C>T	ENST00000369701.3	+	26	3755	c.3528C>T	c.(3526-3528)aaC>aaT	p.N1176N		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1176						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AAAGTGAAAACGCCCCCAAAA	0.512000													3	22					0	0	1	0	0
RBM45	129831	broad.mit.edu	37	2	178981032	178981032	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr2:178981032T>C	ENST00000286070.5	+	2	436	c.344T>C	c.(343-345)gTt>gCt	p.V115A		NM_152945.2	NP_694453.2	Q8IUH3	RBM45_HUMAN	RNA binding motif protein 45	115					cell differentiation|nervous system development	cytoplasm|nucleus	nucleotide binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.00957)|all cancers(119;0.037)			CACCGAGATGTTGAAGATGAA	0.343000													13	57					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr1:145302714A>G	ENST00000342960.5	+	8	1187	c.1152A>G	c.(1150-1152)ttA>ttG	p.L384L	NBPF10_ENST00000369338.1_Silent_p.L113L|RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369339.2_Silent_p.L113L	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	384								p.L113L(3)|p.L384L(3)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													5	128					0	0	1	0	0
OR5T2	219464	broad.mit.edu	37	11	56000287	56000287	+	Silent	SNP	C	C	T			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr11:56000287C>T	ENST00000313264.4	-	1	450	c.375G>A	c.(373-375)acG>acA	p.T125T		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	125			T -> M (in dbSNP:rs7122514).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					TATTCTTTGTCGTAAAATCTA	0.403000													4	52					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66890448	66890448	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr17:66890448A>C	ENST00000269080.2	-	21	2919	c.2782T>G	c.(2782-2784)Tac>Gac	p.Y928D	ABCA8_ENST00000430352.2_Missense_Mutation_p.Y968D|ABCA8_ENST00000586539.1_Missense_Mutation_p.Y968D	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	928						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					GAAAAGCTGTAATTCTAAAAT	0.303000													4	23					0	0	1	0	0
CNTROB	116840	broad.mit.edu	37	17	7849197	7849197	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr17:7849197T>G	ENST00000380262.3	+	13	2811	c.1886T>G	c.(1885-1887)gTt>gGt	p.V629G	CNTROB_ENST00000563694.1_Missense_Mutation_p.V629G|CNTROB_ENST00000565740.1_Missense_Mutation_p.V629G|CNTROB_ENST00000380255.3_3'UTR	NM_001037144.5	NP_001032221.1	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	629	Pro-rich.|Required for centrosome localization.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)	25		Prostate(122;0.173)				GCGCCTCCTGTTCTTTGCAGT	0.587000													4	77					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													4	112					0	0	1	0	0
MTHFD1L	25902	broad.mit.edu	37	6	151239756	151239756	+	Silent	SNP	C	C	T			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr6:151239756C>T	ENST00000367321.3	+	9	1210	c.936C>T	c.(934-936)ctC>ctT	p.L312L		NM_001242767.1|NM_001242768.1|NM_015440.4	NP_001229696.1|NP_001229697.1|NP_056255.2	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	312	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	29		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		TTGGTGGACTCATTGAGGAAG	0.393000													7	55					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107703339	107703339	+	Silent	SNP	C	C	T			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr7:107703339C>T	ENST00000388781.3	-	23	3245	c.3162G>A	c.(3160-3162)ccG>ccA	p.P1054P	LAMB4_ENST00000388780.3_Silent_p.P1054P|LAMB4_ENST00000205386.4_Silent_p.P1054P	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1054	Laminin EGF-like 11.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CTGTGACATTCGGCAGACAAG	0.592000													3	26					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197896792	197896792	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr1:197896792C>A	ENST00000367390.3	+	5	805	c.778C>A	c.(778-780)Cgc>Agc	p.R260S	LHX9_ENST00000367391.1_Missense_Mutation_p.R260S|LHX9_ENST00000561173.1_Missense_Mutation_p.R275S|LHX9_ENST00000367387.4_Missense_Mutation_p.R269S|LHX9_ENST00000337020.2_Missense_Mutation_p.R269S	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	269					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						GAAGACCAAGCGCATGCGAAC	0.527000													14	115					1.52009e-12	1.71497e-12	1	1	0
PTPN1	5770	broad.mit.edu	37	20	49196444	49196444	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr20:49196444G>A	ENST00000371621.3	+	8	1243	c.1069G>A	c.(1069-1071)Gca>Aca	p.A357T	PTPN1_ENST00000541713.1_Missense_Mutation_p.A284T	NM_001278618.1|NM_002827.2	NP_001265547.1|NP_002818.1	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type 1	357					blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|skin(2)	16		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)	CTTAAATGCCGCACCCTACGG	0.498000											OREG0026029	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	46					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164739070	164739070	+	Silent	SNP	G	G	T			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr3:164739070G>T	ENST00000264382.3	-	27	3263	c.3201C>A	c.(3199-3201)atC>atA	p.I1067I		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1067	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GATTTTCCTTGATTTCCACAT	0.343000										HNSCC(35;0.089)			5	94					0.014758	0.0158378	1	1	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													3	37					0	0	1	0	0
CREB3L4	148327	broad.mit.edu	37	1	153941929	153941929	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr1:153941929C>G	ENST00000368607.3	+	4	807	c.541C>G	c.(541-543)Ctg>Gtg	p.L181V	CREB3L4_ENST00000368601.1_Missense_Mutation_p.L181V|CREB3L4_ENST00000405694.3_Missense_Mutation_p.L34V|CREB3L4_ENST00000468845.1_3'UTR|CREB3L4_ENST00000271889.4_Missense_Mutation_p.L181V|CREB3L4_ENST00000368600.3_Missense_Mutation_p.L161V|CREB3L4_ENST00000368603.1_Missense_Mutation_p.L181V	NM_001255978.1|NM_001255980.1|NM_130898.3	NP_001242907.1|NP_001242909.1|NP_570968.1	Q8TEY5	CR3L4_HUMAN	cAMP responsive element binding protein 3-like 4	181					response to unfolded protein	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(3)	13	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTGTACAACCCTGGTGAGTCT	0.517000													5	39					0	0	1	0	0
LINC00264	0	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													3	30					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158592846	158592846	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr1:158592846C>T	ENST00000368148.3	-	43	6227	c.6047G>A	c.(6046-6048)cGc>cAc	p.R2016H	SPTA1_ENST00000461624.1_5'UTR|SPTA1_ENST00000368147.3_Missense_Mutation_p.R2013H	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2016					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton	p.R2016H(1)		NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CTGTTCCCAGCGCTTCAGCAG	0.478000													21	174					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18047889	18047889	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr17:18047889G>A	ENST00000205890.5	+	29	6594	c.6256G>A	c.(6256-6258)Gtg>Atg	p.V2086M		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	2086	MyTH4 1.|Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TGCAGAAGCCGTGAGCATCTT	0.607000													5	30					0	0	1	0	0
ZNF398	0	broad.mit.edu	37	7	148876613	148876613	+	Missense_Mutation	SNP	G	G	A	rs146764677		TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr7:148876613G>A	ENST00000420008.2	+	6	1924	c.1136G>A	c.(1135-1137)cGc>cAc	p.R379H	ZNF398_ENST00000483892.1_Missense_Mutation_p.R379H|ZNF398_ENST00000426851.2_Missense_Mutation_p.R379H|ZNF398_ENST00000475153.1_Missense_Mutation_p.R550H|ZNF398_ENST00000540950.1_Missense_Mutation_p.R555H|ZNF398_ENST00000491174.1_Missense_Mutation_p.R379H|ZNF398_ENST00000335901.4_Missense_Mutation_p.R379H	NM_170686.2	NP_733787.1	Q8TD17	ZN398_HUMAN	zinc finger protein 398	550					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)	25	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)			AGCTTCATCCGCAAGCACCAC	0.597000													3	54					0	0	1	0	0
GALNT18	374378	broad.mit.edu	37	11	11362459	11362459	+	Silent	SNP	G	G	A			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr11:11362459G>A	ENST00000227756.4	-	7	1596	c.1185C>T	c.(1183-1185)acC>acT	p.T395T		NM_198516.2	NP_940918.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18																		GGACATGGGCGGTGAGGTCCT	0.582000													4	139					0	0	1	0	0
ZDHHC4	55146	broad.mit.edu	37	7	6628405	6628405	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr7:6628405G>A	ENST00000396706.2	+	8	1342	c.899G>A	c.(898-900)cGt>cAt	p.R300H	ZDHHC4_ENST00000335965.6_Missense_Mutation_p.R300H|ZDHHC4_ENST00000396709.1_Missense_Mutation_p.R300H|AC079742.4_ENST00000434951.1_RNA|ZDHHC4_ENST00000396713.2_Missense_Mutation_p.R300H|ZDHHC4_ENST00000405731.3_Missense_Mutation_p.R300H|ZDHHC4_ENST00000396707.2_Missense_Mutation_p.R300H			Q9NPG8	ZDHC4_HUMAN	zinc finger, DHHC-type containing 4	300						integral to membrane	acyltransferase activity|zinc ion binding	p.R300H(2)		breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.1)		TGGTGCCAGCGTTGTCCCCTT	0.577000													5	54					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1808052	1808052	+	Silent	SNP	C	C	T			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr4:1808052C>T	ENST00000340107.4	+	15	2290	c.2034C>T	c.(2032-2034)gaC>gaT	p.D678D	FGFR3_ENST00000481110.2_Intron|FGFR3_ENST00000352904.1_Silent_p.D564D|FGFR3_ENST00000260795.2_Silent_p.D676D|FGFR3_ENST00000412135.2_Silent_p.D564D|FGFR3_ENST00000440486.2_Silent_p.D676D	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	676	Protein kinase.				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACCAGAGTGACGTGTACGTGT	0.667000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				3	34					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55533894	55533894	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr8:55533894G>A	ENST00000220676.1	+	2	516	c.368G>A	c.(367-369)cGc>cAc	p.R123H		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	123					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GCCCGTCGGCGCCCGCGGCCC	0.706000													5	68					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245851624	245851624	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr1:245851624C>T	ENST00000366518.4	+	9	4300	c.4196C>T	c.(4195-4197)aCg>aTg	p.T1399M	KIF26B_ENST00000407071.2_Missense_Mutation_p.T1780M			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1780					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			GGGAAGCACACGCCCTGGTCC	0.711000													4	22					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5048842	5048842	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr17:5048842C>A	ENST00000574788.1	+	27	4365	c.2135C>A	c.(2134-2136)cCa>cAa	p.P712Q	USP6_ENST00000332776.4_Missense_Mutation_p.P712Q|USP6_ENST00000304328.5_Missense_Mutation_p.P395Q|USP6_ENST00000250066.6_Missense_Mutation_p.P712Q			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	712					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TTGCCACTACCAATGGACAGT	0.348000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								6	57					0.0215528	0.0225791	1	1	0
MAGI2	9863	broad.mit.edu	37	7	77973249	77973249	+	Silent	SNP	G	G	T			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr7:77973249G>T	ENST00000354212.4	-	9	1507	c.1254C>A	c.(1252-1254)tcC>tcA	p.S418S	MAGI2_ENST00000522391.1_Silent_p.S418S|MAGI2_ENST00000419488.1_Silent_p.S418S|MAGI2_ENST00000535697.1_Silent_p.S255S|MAGI2_ENST00000536571.1_Silent_p.S250S	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	418						cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CCTTCAACTGGGATGCATCCC	0.443000													5	35					0.217242	0.222294	1	1	0
TUBB8P7	0	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr16:90162513T>C	ENST00000567960.1	+	0	1249				TUBB8P7_ENST00000564451.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													4	77					0	0	1	0	0
FRMD6	122786	broad.mit.edu	37	14	52179204	52179204	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr14:52179204T>G	ENST00000395718.2	+	9	1045	c.760T>G	c.(760-762)Tta>Gta	p.L254V	FRMD6_ENST00000356218.4_Missense_Mutation_p.L254V|FRMD6_ENST00000554167.1_Missense_Mutation_p.L185V|FRMD6_ENST00000344768.5_Missense_Mutation_p.L262V	NM_001267046.1|NM_152330.3	NP_001253975.1|NP_689543.1	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	262	FERM.					cytoskeleton|mitochondrion|plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_epithelial(31;0.0163)|Breast(41;0.089)					TTCACAGAATTTAGATGAAGA	0.303000													4	16					0	0	1	0	0
SIRPB2	284759	broad.mit.edu	37	20	1459194	1459194	+	Silent	SNP	C	C	A			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr20:1459194C>A	ENST00000359801.3	-	3	546	c.510G>T	c.(508-510)ggG>ggT	p.G170G	SIRPB2_ENST00000537284.1_Silent_p.G32G|SIRPB2_ENST00000444444.1_Silent_p.G72G|SIRPB2_ENST00000381630.1_Silent_p.G72G	NM_001122962.1	NP_001116434.1	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2	170	Ig-like V-type 2.					integral to membrane				endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CTCCAGTGGTCCCCAACACCA	0.587000													5	45					0.014758	0.0158378	1	1	0
AMZ2	51321	broad.mit.edu	37	17	66251917	66251917	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr17:66251917A>G	ENST00000359904.3	+	6	1959	c.827A>G	c.(826-828)aAc>aGc	p.N276S	AMZ2_ENST00000577866.1_Missense_Mutation_p.N276S|AMZ2_ENST00000577273.1_Intron|AMZ2_ENST00000585050.1_Intron|AMZ2_ENST00000392720.2_Missense_Mutation_p.N276S|AMZ2_ENST00000359783.4_Missense_Mutation_p.N218S|AMZ2_ENST00000577985.1_Missense_Mutation_p.N276S|AMZ2_ENST00000580753.1_Missense_Mutation_p.N276S	NM_016627.4	NP_057711.3	Q86W34	AMZ2_HUMAN	archaelysin family metallopeptidase 2	276							metallopeptidase activity|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	9	all_cancers(12;1.12e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)			CAAGGCTCCAACCACTTGGAA	0.488000													11	63					0	0	1	0	0
STX1B	112755	broad.mit.edu	37	16	31004421	31004421	+	Silent	SNP	G	G	A			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr16:31004421G>A	ENST00000565419.1	-	9	815	c.816C>T	c.(814-816)ggC>ggT	p.G272G	STX1B_ENST00000215095.5_Intron			P61266	STX1B_HUMAN	syntaxin 1B	0					intracellular protein transport|neurotransmitter transport|synaptic transmission	integral to plasma membrane	extracellular-glutamate-gated ion channel activity|SNAP receptor activity			breast(2)|endometrium(1)|large_intestine(5)|lung(5)	13						GGGCTCCCCCGCCTACCCCCA	0.627000													5	24					0	0	1	0	0
PDYN	5173	broad.mit.edu	37	20	1961195	1961195	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr20:1961195C>T	ENST00000217305.2	-	4	764	c.539G>A	c.(538-540)cGc>cAc	p.R180H	PDYN_ENST00000539905.1_Missense_Mutation_p.R180H|PDYN_ENST00000540134.1_Missense_Mutation_p.R180H|RP4-684O24.5_ENST00000446562.1_RNA	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	180					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GGGGTATTTGCGCAAAAAGCC	0.602000													16	75					0	0	1	0	0
SEL1L	6400	broad.mit.edu	37	14	81950619	81950619	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr14:81950619C>A	ENST00000336735.4	-	19	2112	c.1996G>T	c.(1996-1998)Gct>Tct	p.A666S		NM_005065.5	NP_005056.3	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like (C. elegans)	666	Interaction with ERLEC1, OS9 and SYVN1.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(3)	28				BRCA - Breast invasive adenocarcinoma(234;0.0299)		TTAAACATAGCTTGTGCACTG	0.428000													4	219					1	1	1	1	0
DNM1P47	0	broad.mit.edu	37	15	102292820	102292820	+	RNA	SNP	G	G	C			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr15:102292820G>C	ENST00000561463.1	+	0	866																		p.T136T(2)									GCGTGGGAACGAGAAGACACT	0.592000													3	22					0	0	1	0	0
ZNF595	152687	broad.mit.edu	37	4	59341	59341	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr4:59341G>A	ENST00000509152.2	+	2	207	c.22G>A	c.(22-24)Gat>Aat	p.D8N	ZNF595_ENST00000339368.6_3'UTR|ZNF595_ENST00000526473.2_Missense_Mutation_p.D8N					zinc finger protein 595											endometrium(5)|kidney(1)|large_intestine(1)|lung(11)|prostate(2)	20		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		AACATTCAGGGATGTGGCCAT	0.418000													5	356					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921147	24921147	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr15:24921147C>T	ENST00000329468.2	+	1	607	c.133C>T	c.(133-135)Cgc>Tgc	p.R45C		NM_018958.2	NP_061831.2			nuclear pore associated protein 1									p.R45C(1)									ACCCACCCCGCGCCCTTTCCG	0.761000													3	20					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													3	31					0	0	1	0	0
HSPA8	3312	broad.mit.edu	37	11	122930500	122930500	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr11:122930500A>C	ENST00000534624.1	-	5	1077	c.801T>G	c.(799-801)tgT>tgG	p.C267W	HSPA8_ENST00000526862.1_Intron|HSPA8_ENST00000526110.1_Missense_Mutation_p.C248W|HSPA8_ENST00000453788.2_Missense_Mutation_p.C267W|HSPA8_ENST00000227378.3_Missense_Mutation_p.C267W|HSPA8_ENST00000534319.1_Missense_Mutation_p.C31W|HSPA8_ENST00000533540.1_Missense_Mutation_p.C121W|HSPA8_ENST00000532636.1_Missense_Mutation_p.C267W	NM_006597.4	NP_006588.1	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8	267	Interaction with BAG1.				cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			breast(1)|central_nervous_system(7)|endometrium(1)|kidney(9)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	36		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TAGCACGTTCACAAGCAGTAC	0.478000													6	36					0	0	1	0	0
SPON2	10417	broad.mit.edu	37	4	1165174	1165174	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr4:1165174C>T	ENST00000290902.5	-	3	653	c.321G>A	c.(319-321)atG>atA	p.M107I	SPON2_ENST00000431380.1_Missense_Mutation_p.M107I	NM_012445.3	NP_036577.1	Q9BUD6	SPON2_HUMAN	spondin 2, extracellular matrix protein	107	Spondin.				axon guidance|cell adhesion|innate immune response	proteinaceous extracellular matrix	metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|pancreas(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(23;0.00805)	UCEC - Uterine corpus endometrioid carcinoma (64;0.139)|Colorectal(103;0.19)		CGATCTCCTTCATCAGCGCCC	0.701000													3	30					0	0	1	0	0
M1AP	130951	broad.mit.edu	37	2	74785922	74785922	+	Missense_Mutation	SNP	T	T	G			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr2:74785922T>G	ENST00000290536.5	-	11	1630	c.1514A>C	c.(1513-1515)aAg>aCg	p.K505T	M1AP_ENST00000536235.1_Missense_Mutation_p.K501T|M1AP_ENST00000409585.1_Missense_Mutation_p.K501T|M1AP_ENST00000358434.2_Missense_Mutation_p.K154T|M1AP_ENST00000464686.1_5'UTR	NM_138804.3	NP_620159.2			meiosis 1 associated protein																		TGCTGGCATCTTGGAGGCTCT	0.587000													11	40					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245319797	245319797	+	Frame_Shift_Del	DEL	G	G	-			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr1:245319797delG	ENST00000407071.2	+	2	717	c.277delG	c.(277-279)gcfs	p.G93fs		NM_018012.3	NP_060482.2	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	93	Gly-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CCCCGGCATCGGCACTAGTTC	0.786													2	4	---	---	---	---					
TRIP12	9320	broad.mit.edu	37	2	230662405	230662405	+	Splice_Site	DEL	C	C	-			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr2:230662405delC	ENST00000283943.5	-	23	3578		c.e23+1		TRIP12_ENST00000389045.3_Splice_Site|TRIP12_ENST00000543084.1_Splice_Site|TRIP12_ENST00000389044.4_Splice_Site	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		GGACACAGCACCTGGAGGTTG	0.448													9	43	---	---	---	---					
PHC3	80012	broad.mit.edu	37	3	169889137	169889138	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr3:169889137_169889138insA	ENST00000497658.1	-	4	454_455	c.437_438insT	c.(436-438)tctfs	p.S146fs	PHC3_ENST00000467570.1_Intron|PHC3_ENST00000495893.1_Intron|PHC3_ENST00000474275.1_Intron|PHC3_ENST00000494943.1_Intron|PHC3_ENST00000481639.1_Frame_Shift_Ins_p.S142fs			Q8NDX5	PHC3_HUMAN	polyhomeotic homolog 3 (Drosophila)	782	Ser-rich.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TTAAATCCAGGAAAAAAAAATT	0.337													3	4	---	---	---	---					
SYNE1	23345	broad.mit.edu	37	6	152708427	152708428	+	Frame_Shift_Ins	INS	-	-	T			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr6:152708427_152708428insT	ENST00000367255.5	-	54	8867_8868	c.8266_8267insA	c.(8266-8268)agafs	p.R2756fs	SYNE1_ENST00000423061.1_Frame_Shift_Ins_p.R2763fs|SYNE1_ENST00000448038.1_Frame_Shift_Ins_p.R2763fs|SYNE1_ENST00000341594.5_Frame_Shift_Ins_p.R2795fs|SYNE1_ENST00000265368.4_Frame_Shift_Ins_p.R2756fs	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2756					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGGATGTTCTATTTTTTGATCC	0.455										HNSCC(10;0.0054)			7	50	---	---	---	---					
LSP1	4046	broad.mit.edu	37	11	1874395	1874395	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr11:1874395delC	ENST00000311604.3	+	1	196	c.21delC	c.(19-21)gafs	p.D7fs		NM_002339.2	NP_002330.1	P33241	LSP1_HUMAN	lymphocyte-specific protein 1	7					cellular component movement|cellular defense response	actin cytoskeleton|Golgi apparatus|plasma membrane	actin binding|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|Lung(200;0.0729)|LUSC - Lung squamous cell carcinoma(625;0.0856)		CTTCGAGTGACCCGGGTGCCG	0.652													2	4	---	---	---	---					
KCNQ2	3785	broad.mit.edu	37	20	62073806	62073806	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XK-AAIR-01A-11D-A41K-08	TCGA-XK-AAIR-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab4e6321-19ec-44d9-aa53-2391911d92d0	bba1d69c-c2b1-4f84-82c8-b54699187c99	g.chr20:62073806delC	ENST00000354587.3	-	5	945	c.769delG	c.(769-771)agfs	p.E257fs	KCNQ2_ENST00000370226.1_Frame_Shift_Del_p.E257fs|KCNQ2_ENST00000430658.1_Frame_Shift_Del_p.E257fs|KCNQ2_ENST00000370222.3_Frame_Shift_Del_p.E257fs|KCNQ2_ENST00000357249.2_Frame_Shift_Del_p.E257fs|KCNQ2_ENST00000370224.1_Frame_Shift_Del_p.E257fs|KCNQ2_ENST00000359125.2_Frame_Shift_Del_p.E257fs|KCNQ2_ENST00000344425.5_Frame_Shift_Del_p.E257fs|KCNQ2_ENST00000344462.3_Frame_Shift_Del_p.E257fs|KCNQ2_ENST00000370221.1_Frame_Shift_Del_p.E257fs|KCNQ2_ENST00000360480.3_Frame_Shift_Del_p.E257fs|KCNQ2_ENST00000359689.1_Frame_Shift_Del_p.E257fs			O43526	KCNQ2_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 2	257					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|liver(1)|lung(30)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	TGGTCGTTCTCCCCCTTCTCT	0.582													34	182	---	---	---	---