Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FRG1B	0	broad.mit.edu	37	20	29628236	29628236	+	Missense_Mutation	SNP	G	G	C	rs145412486	by1000genomes	TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr20:29628236G>C	ENST00000278882.3	+	6	618	c.238G>C	c.(238-240)Gct>Cct	p.A80P	FRG1B_ENST00000439954.2_Missense_Mutation_p.A85P|FRG1B_ENST00000358464.4_Missense_Mutation_p.A80P														p.A80P(8)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGGAAAATGGCTTTGTTGGC	0.363000													4	79					0	0	1	0	0
PI3	5266	broad.mit.edu	37	20	43804750	43804750	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr20:43804750G>A	ENST00000243924.3	+	2	375	c.328G>A	c.(328-330)Ggg>Agg	p.G110R		NM_002638.3	NP_002629.1	P19957	ELAF_HUMAN	peptidase inhibitor 3, skin-derived	110	WAP.				copulation	proteinaceous extracellular matrix	serine-type endopeptidase inhibitor activity	p.G110W(1)		large_intestine(1)|lung(5)|skin(1)	7		Myeloproliferative disorder(115;0.0122)				AGGCTCTTGCGGGATGGCCTG	0.552000													4	52					0	0	1	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44799776	44799776	+	Silent	SNP	C	C	T			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr7:44799776C>T	ENST00000309315.4	+	8	1143	c.1020C>T	c.(1018-1020)ggC>ggT	p.G340G	ZMIZ2_ENST00000441627.1_Silent_p.G340G|ZMIZ2_ENST00000433667.1_Silent_p.G308G|ZMIZ2_ENST00000413916.1_Intron|ZMIZ2_ENST00000265346.7_Intron	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	340	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						ACGGGCAGGGCGCCAGCTTCA	0.687000													4	28					0	0	1	0	0
SEMA4F	10505	broad.mit.edu	37	2	74889931	74889931	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr2:74889931C>T	ENST00000357877.2	+	5	678	c.529C>T	c.(529-531)Cgg>Tgg	p.R177W	SEMA4F_ENST00000339773.5_Intron	NM_004263.3	NP_004254.2	O95754	SEM4F_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F	177	Sema.				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			biliary_tract(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	45						GCCAGCTCAGCGGTCAGCAGC	0.507000													26	87					0	0	1	0	0
PSG11	5680	broad.mit.edu	37	19	43529017	43529017	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr19:43529017C>T	ENST00000401740.1	-	2	359	c.256G>A	c.(256-258)Ggt>Agt	p.G86S	PSG11_ENST00000306322.7_Intron|PSG11_ENST00000403486.1_Intron|PSG11_ENST00000320078.7_Missense_Mutation_p.G86S			Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	86	Ig-like V-type.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	26		Prostate(69;0.00682)				ATTATTTGACCGTCTACTACA	0.448000													11	202					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81891938	81891938	+	Silent	SNP	G	G	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr16:81891938G>A	ENST00000359376.3	+	4	622	c.408G>A	c.(406-408)gcG>gcA	p.A136A	PLCG2_ENST00000565400.1_3'UTR	NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	136					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						CGATGAATGCGTCCACGCCCA	0.478000													13	72					0	0	1	0	0
DRD5	0	broad.mit.edu	37	4	9784459	9784459	+	Missense_Mutation	SNP	C	C	T	rs2227842	by1000genomes	TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr4:9784459C>T	ENST00000304374.2	+	1	1202	c.806C>T	c.(805-807)gCg>gTg	p.A269V		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	269			A -> V (in dbSNP:rs2227842).		activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GCAGAGCACGCGCAGAGCTGC	0.632000													4	26					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578400	7578400	+	Missense_Mutation	SNP	G	G	C			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr17:7578400G>C	ENST00000420246.2	-	5	662	c.530C>G	c.(529-531)cCc>cGc	p.P177R	TP53_ENST00000445888.2_Missense_Mutation_p.P177R|TP53_ENST00000269305.4_Missense_Mutation_p.P177R|TP53_ENST00000574684.1_5'UTR|TP53_ENST00000359597.4_Missense_Mutation_p.P177R|TP53_ENST00000455263.2_Missense_Mutation_p.P177R|TP53_ENST00000413465.2_Missense_Mutation_p.P177R	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	177	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		CP -> FS (in a sporadic cancer; somatic mutation).|P -> A (in a sporadic cancer; somatic mutation).|P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> H (in sporadic cancers; somatic mutation).|P -> I (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|P -> L (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> T (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P177R(18)|p.P177L(17)|p.P177_C182delPHHERC(8)|p.0?(8)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.P177H(3)|p.R175_E180delRCPHHE(3)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.C176fs*65(1)|p.C176_P177delCP(1)|p.V173fs*69(1)|p.C176fs*68(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.P177fs*69(1)|p.R175_H178>X(1)|p.H168fs*69(1)|p.E171_H179delEVVRRCPHH(1)|p.P45R(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.P177I(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.P84R(1)|p.R174fs*3(1)|p.E171fs*61(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTCATGGTGGGGGCAGCGCCT	0.647000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	41					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46806424	46806424	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr22:46806424C>T	ENST00000262738.3	-	7	4803	c.4804G>A	c.(4804-4806)Ggt>Agt	p.G1602S		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1602	Laminin G-like 1.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TTGGGGACACCCCCCAGGAGT	0.642000													3	50					0	0	1	0	0
IGKV1-9	0	broad.mit.edu	37	2	89309619	89309619	+	RNA	SNP	A	A	G			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr2:89309619A>G	ENST00000493819.1	-	0	268																											GATGCAGCATAGATCAGGAGC	0.522000													40	138					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56088563	56088563	+	Splice_Site	SNP	G	G	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr12:56088563G>A	ENST00000257880.7	-	16	2546	c.2328_splice	c.e16+1	p.A776_splice	ITGA7_ENST00000553804.1_Splice_Site_p.A736_splice|ITGA7_ENST00000394229.2_Splice_Site_p.A732_splice|ITGA7_ENST00000394230.2_Splice_Site_p.A736_splice|ITGA7_ENST00000452168.2_Splice_Site_p.A639_splice|ITGA7_ENST00000555728.1_Splice_Site_p.A776_splice|ITGA7_ENST00000347027.6_Splice_Site_p.A726_splice|ITGA7_ENST00000257879.6_Splice_Site_p.A732_splice			Q13683	ITA7_HUMAN	integrin, alpha 7	776					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity	p.A732V(1)|p.A736V(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GGTCCTCACCGCAGGGTCCAG	0.637000													7	52					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	20119208	20119208	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr11:20119208G>A	ENST00000396085.1	+	32	6468	c.6107G>A	c.(6106-6108)cGc>cAc	p.R2036H	NAV2_ENST00000360655.4_Missense_Mutation_p.R1969H|NAV2_ENST00000349880.4_Missense_Mutation_p.R2033H|NAV2_ENST00000311043.8_Missense_Mutation_p.R1097H|NAV2_ENST00000533917.1_Missense_Mutation_p.R1097H|NAV2_ENST00000527559.2_Missense_Mutation_p.R2021H|NAV2_ENST00000396087.3_Missense_Mutation_p.R2092H|NAV2_ENST00000540292.1_Missense_Mutation_p.R2023H	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	2092						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						GAAATCAAGCGCAGCAACACT	0.468000													13	75					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr12:25398284C>T	ENST00000311936.3	-	2	226	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000256078.4_Missense_Mutation_p.G12D	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			8	43					0	0	1	0	0
TARS	6897	broad.mit.edu	37	5	33459873	33459873	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr5:33459873C>T	ENST00000265112.3	+	11	1468	c.1157C>T	c.(1156-1158)tCg>tTg	p.S386L	TARS_ENST00000541634.1_Missense_Mutation_p.S282L|TARS_ENST00000414361.2_Missense_Mutation_p.S265L|TARS_ENST00000502553.1_Missense_Mutation_p.S386L|TARS_ENST00000455217.2_Missense_Mutation_p.S419L	NM_152295.4	NP_689508.3	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	386					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			NS(1)|biliary_tract(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)	29					L-Threonine(DB00156)	TGGATGACCTCGGGCCACTGG	0.493000													12	65					0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57963897	57963897	+	Silent	SNP	G	G	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr12:57963897G>A	ENST00000455537.2	+	12	1519	c.1245G>A	c.(1243-1245)caG>caA	p.Q415Q	KIF5A_ENST00000286452.5_Silent_p.Q326Q	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	415					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						AGGAGCGGCAGAAATACGAGG	0.632000													6	24					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5294673	5294673	+	Missense_Mutation	SNP	C	C	T	rs138672528	by1000genomes	TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr20:5294673C>T	ENST00000546004.1	-	2	589	c.343G>A	c.(343-345)Gtg>Atg	p.V115M	PROKR2_ENST00000217270.3_Missense_Mutation_p.V115M			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	115						integral to membrane|plasma membrane	neuropeptide Y receptor activity	p.V115M(1)		autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						TGCCGTACCACGTAGTAGTCC	0.587000										HNSCC(71;0.22)			13	37					0	0	1	0	0
OR10W1	81341	broad.mit.edu	37	11	58034735	58034735	+	Missense_Mutation	SNP	G	G	T			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr11:58034735G>T	ENST00000395079.2	-	1	997	c.596C>A	c.(595-597)gCt>gAt	p.A199D		NM_207374.3	NP_997257.2	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W, member 1	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(1)	26		Breast(21;0.0589)				GAAAGGCACAGCAATGGCTAG	0.547000													3	28					0.115264	0.117286	1	1	0
ZNF99	7652	broad.mit.edu	37	19	22941154	22941154	+	Missense_Mutation	SNP	C	C	G			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr19:22941154C>G	ENST00000397104.3	-	5	1283	c.1284G>C	c.(1282-1284)aaG>aaC	p.K428N	ZNF99_ENST00000596209.1_Missense_Mutation_p.K519N					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CTGAGAAATGCTTAAAAGCTT	0.353000													4	62					0	0	1	0	0
CAPN15	6650	broad.mit.edu	37	16	603374	603374	+	Missense_Mutation	SNP	A	A	G			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr16:603374A>G	ENST00000219611.2	+	14	3482	c.3119A>G	c.(3118-3120)aAc>aGc	p.N1040S	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		CTAGAGGGCAACGCCGGCTTC	0.677000													21	41					0	0	1	0	0
C7orf31	136895	broad.mit.edu	37	7	25182283	25182283	+	Missense_Mutation	SNP	T	T	C			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr7:25182283T>C	ENST00000409280.1	-	8	1143	c.835A>G	c.(835-837)Act>Gct	p.T279A	C7orf31_ENST00000283905.3_Missense_Mutation_p.T279A			Q8N865	CG031_HUMAN	chromosome 7 open reading frame 31	279										autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|skin(2)|stomach(1)	14						GTGTACGAAGTGAGCCAGTGG	0.358000													12	53					0	0	1	0	0
PITRM1	10531	broad.mit.edu	37	10	3185630	3185630	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr10:3185630C>T	ENST00000380989.2	-	23	2637	c.2599G>A	c.(2599-2601)Gtg>Atg	p.V867M	PITRM1-AS1_ENST00000601046.1_RNA|PITRM1-AS1_ENST00000598280.1_RNA|PITRM1-AS1_ENST00000441377.1_RNA|PITRM1_ENST00000451104.2_Missense_Mutation_p.V768M|PITRM1_ENST00000224949.4_Missense_Mutation_p.V866M|PITRM1_ENST00000464395.1_5'UTR|PITRM1_ENST00000380994.1_Missense_Mutation_p.V424M	NM_001242307.1|NM_014889.3	NP_001229236.1|NP_055704.2	E7ES23	E7ES23_HUMAN	pitrilysin metallopeptidase 1	768					proteolysis		metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|urinary_tract(3)	33						CATTCACCCACGTAATTCACC	0.587000													15	45					0	0	1	0	0
TMEM260	54916	broad.mit.edu	37	14	57075905	57075905	+	Missense_Mutation	SNP	T	T	C			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr14:57075905T>C	ENST00000261556.6	+	6	840	c.718T>C	c.(718-720)Tct>Cct	p.S240P	TMEM260_ENST00000538838.1_Missense_Mutation_p.S240P|TMEM260_ENST00000536419.1_5'UTR	NM_017799.3	NP_060269.3			transmembrane protein 260																		TCCCATCTCATCTTACCTTAA	0.502000													37	151					0	0	1	0	0
ASAP1	50807	broad.mit.edu	37	8	131130463	131130463	+	Silent	SNP	G	G	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr8:131130463G>A	ENST00000357668.1	-	19	1851	c.1824C>T	c.(1822-1824)gcC>gcT	p.A608A	ASAP1_ENST00000518721.1_Silent_p.A608A			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	608					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						CAGTTCGGACGGCAAGGTGAA	0.408000													4	18					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99448880	99448880	+	Silent	SNP	G	G	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr2:99448880G>A	ENST00000397899.2	-	5	802	c.471C>T	c.(469-471)gaC>gaT	p.D157D	KIAA1211L_ENST00000462314.1_5'UTR	NM_207362.2	NP_997245.2			KIAA1211-like									p.D157D(2)									GCAGCCCGTCGTCCTCAGAGC	0.587000													12	39					0	0	1	0	0
MED12	9968	broad.mit.edu	37	X	70349256	70349256	+	Missense_Mutation	SNP	T	T	G			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chrX:70349256T>G	ENST00000333646.6	+	26	3867	c.3668T>G	c.(3667-3669)gTt>gGt	p.V1223G	MED12_ENST00000374080.3_Missense_Mutation_p.V1223G|MED12_ENST00000374102.1_Missense_Mutation_p.V1223G	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	1223					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					GTGTTTGCTGTTCTCAAGGCT	0.567000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome				OREG0019857	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	9					0	0	1	0	0
POLR2B	5431	broad.mit.edu	37	4	57889904	57889904	+	Missense_Mutation	SNP	A	A	G			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr4:57889904A>G	ENST00000381227.1	+	21	3256	c.2843A>G	c.(2842-2844)cAg>cGg	p.Q948R	POLR2B_ENST00000314595.5_Missense_Mutation_p.Q948R|POLR2B_ENST00000441246.2_Missense_Mutation_p.Q941R|POLR2B_ENST00000431623.2_Missense_Mutation_p.Q873R			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	948					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					TGTGGTATTCAGTATAGACAA	0.333000													14	42					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201777624	201777624	+	Silent	SNP	G	G	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr1:201777624G>A	ENST00000367296.4	+	19	4344	c.3924G>A	c.(3922-3924)tcG>tcA	p.S1308S	NAV1_ENST00000367297.4_Silent_p.S1300S|NAV1_ENST00000367295.1_Silent_p.S914S|NAV1_ENST00000295624.6_Silent_p.S1305S|NAV1_ENST00000367302.1_Silent_p.S1261S|IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367300.3_Silent_p.S1248S	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1308					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding	p.S1305S(1)		breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						AGGAGGTATCGGAGCTGCGCT	0.562000													3	26					0	0	1	0	0
HLA-DOA	3111	broad.mit.edu	37	6	32975186	32975186	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr6:32975186C>T	ENST00000229829.5	-	3	590	c.515G>A	c.(514-516)cGc>cAc	p.R172H	HLA-DOA_ENST00000450833.2_Missense_Mutation_p.R142H	NM_002119.3	NP_002110.1	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO alpha	172	Alpha-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(1)	9						GTGGAACTTGCGGAACAAATG	0.597000													4	111					0	0	1	0	0
HGF	3082	broad.mit.edu	37	7	81339552	81339552	+	Silent	SNP	T	T	G			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr7:81339552T>G	ENST00000222390.5	-	13	1678	c.1452A>C	c.(1450-1452)gtA>gtC	p.V484V	HGF_ENST00000457544.2_Silent_p.V479V	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	484					epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						CACAAGATATTACGGGATCTG	0.313000													13	69					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926499	1926499	+	Nonsense_Mutation	SNP	C	C	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr2:1926499C>A	ENST00000399161.2	-	10	1789	c.1042G>T	c.(1042-1044)Gag>Tag	p.E348*	MYT1L_ENST00000428368.2_Nonsense_Mutation_p.E348*	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	348					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GGATTCCTCTCCTGCGGGTTG	0.572000													6	39					1	1	1	1	0
HDAC5	10014	broad.mit.edu	37	17	42168661	42168661	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr17:42168661C>T	ENST00000225983.6	-	11	1690	c.1367G>A	c.(1366-1368)cGg>cAg	p.R456Q	HDAC5_ENST00000586802.1_Missense_Mutation_p.R455Q|HDAC5_ENST00000393622.2_Missense_Mutation_p.R455Q|HDAC5_ENST00000336057.5_Missense_Mutation_p.R455Q			Q9UQL6	HDAC5_HUMAN	histone deacetylase 5	455					B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	21		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		GCTCTGCTGCCGGGCCTGCTC	0.637000													3	11					0	0	1	0	0
CTNND1	1500	broad.mit.edu	37	11	57569254	57569254	+	Missense_Mutation	SNP	T	T	C			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr11:57569254T>C	ENST00000524630.1	+	7	1519	c.1006T>C	c.(1006-1008)Tgg>Cgg	p.W336R	CTNND1_ENST00000526938.1_Missense_Mutation_p.W336R|CTNND1_ENST00000529919.1_Missense_Mutation_p.W336R|CTNND1_ENST00000399050.4_Missense_Mutation_p.W336R|CTNND1_ENST00000358694.6_Missense_Mutation_p.W336R|CTNND1_ENST00000534579.1_Missense_Mutation_p.W282R|CTNND1_ENST00000527467.1_Missense_Mutation_p.W13R|CTNND1_ENST00000361332.4_Missense_Mutation_p.W336R|CTNND1_ENST00000533667.1_Missense_Mutation_p.W13R|CTNND1_ENST00000528621.1_Missense_Mutation_p.W282R|CTNND1_ENST00000532844.1_Missense_Mutation_p.W282R|CTNND1_ENST00000426142.2_Missense_Mutation_p.W235R|CTNND1_ENST00000530094.1_Missense_Mutation_p.W235R|CTNND1_ENST00000528232.1_Missense_Mutation_p.W235R|CTNND1_ENST00000532787.1_Missense_Mutation_p.W235R|CTNND1_ENST00000428599.2_Missense_Mutation_p.W336R|CTNND1_ENST00000360682.6_Missense_Mutation_p.W336R|CTNND1_ENST00000532463.1_Missense_Mutation_p.W235R|CTNND1_ENST00000526357.1_Missense_Mutation_p.W282R|CTNND1_ENST00000529526.1_Missense_Mutation_p.W282R|CTNND1_ENST00000532649.1_Missense_Mutation_p.W282R|CTNND1_ENST00000532245.1_Missense_Mutation_p.W235R|CTNND1_ENST00000530748.1_Missense_Mutation_p.W282R|CTNND1_ENST00000529873.1_Missense_Mutation_p.W282R|CTNND1_ENST00000399039.4_Missense_Mutation_p.W336R|CTNND1_ENST00000361796.4_Missense_Mutation_p.W336R|CTNND1_ENST00000415361.2_Missense_Mutation_p.W235R|CTNND1_ENST00000526772.1_Missense_Mutation_p.W13R|CTNND1_ENST00000531014.1_Missense_Mutation_p.W13R|CTNND1_ENST00000361391.6_Missense_Mutation_p.W336R|CTNND1_ENST00000529986.1_Missense_Mutation_p.W235R|CTNND1_ENST00000525902.1_Missense_Mutation_p.W13R			O60716	CTND1_HUMAN	catenin (cadherin-associated protein), delta 1	336					adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(5)|endometrium(8)|kidney(4)|large_intestine(7)|liver(2)|lung(16)|ovary(1)|upper_aerodigestive_tract(2)	45		all_epithelial(135;0.155)				TCAATACTACTGGGCTCCTTT	0.507000													8	39					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38645343	38645343	+	RNA	SNP	C	C	T	rs75687299	by1000genomes	TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr10:38645343C>T	ENST00000494540.1	+	0	36					NR_003086.1																						AAAGCAGCGGCGGCGTTTGCT	0.597000													3	9					0	0	1	0	0
PCDHGB2	0	broad.mit.edu	37	5	140741242	140741242	+	Missense_Mutation	SNP	G	G	C			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr5:140741242G>C	ENST00000522605.1	+	1	1540	c.1540G>C	c.(1540-1542)Gtg>Ctg	p.V514L	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCGGGGTGGTGTTCGCGCA	0.662000													17	64					0	0	1	0	0
IPO8	10526	broad.mit.edu	37	12	30790010	30790010	+	Silent	SNP	G	G	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr12:30790010G>A	ENST00000256079.4	-	22	2939	c.2601C>T	c.(2599-2601)ttC>ttT	p.F867F	IPO8_ENST00000544829.1_Silent_p.F662F	NM_006390.3	NP_006381.2	O15397	IPO8_HUMAN	importin 8	867					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(16)|liver(1)|lung(22)|prostate(2)|skin(2)|urinary_tract(2)	52	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CAAGGAAAAGGAAAAGAATTG	0.428000													16	76					0	0	1	0	0
CCDC171	203238	broad.mit.edu	37	9	15971695	15971695	+	Missense_Mutation	SNP	T	T	C			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr9:15971695T>C	ENST00000380701.3	+	26	4170	c.3842T>C	c.(3841-3843)tTg>tCg	p.L1281S	CCDC171_ENST00000486641.2_Intron	NM_173550.2	NP_775821.2	Q6TFL3	CI093_HUMAN	coiled-coil domain containing 171	1281																	TTCTTACCATTGAAAGCTGAA	0.418000													13	94					0	0	1	0	0
SYNPO	11346	broad.mit.edu	37	5	150028001	150028001	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr5:150028001C>T	ENST00000394243.1	+	3	1270	c.896C>T	c.(895-897)cCg>cTg	p.P299L	SYNPO_ENST00000519664.1_Missense_Mutation_p.P55L|SYNPO_ENST00000307662.4_Missense_Mutation_p.P55L|SYNPO_ENST00000522122.1_Missense_Mutation_p.P299L|SYNPO_ENST00000518872.1_Intron	NM_001166208.1	NP_001159680.1	Q8N3V7	SYNPO_HUMAN	synaptopodin	299					positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			NS(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(4)|prostate(1)|urinary_tract(2)	18		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGTCCTCACCGGCCCCACCT	0.582000													9	84					0	0	1	0	0
GOLGA8DP	0	broad.mit.edu	37	15	22709637	22709637	+	RNA	SNP	T	T	G	rs140467724	by1000genomes	TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr15:22709637T>G	ENST00000314246.8	-	0	1147																											CCCATCTGGTTTTTGAGTTTG	0.547000													4	148					0	0	1	0	0
MBOAT1	154141	broad.mit.edu	37	6	20113231	20113231	+	Missense_Mutation	SNP	T	T	C			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr6:20113231T>C	ENST00000541730.1	-	10	1233	c.638A>G	c.(637-639)tAt>tGt	p.Y213C	MBOAT1_ENST00000324607.7_Missense_Mutation_p.Y362C			Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain containing 1	362					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(5)	20	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			AACCCGCTGATAGCACACACT	0.458000													4	16					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220354264	220354264	+	Missense_Mutation	SNP	C	C	G			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr2:220354264C>G	ENST00000312358.7	+	36	8656	c.8524C>G	c.(8524-8526)Ccc>Gcc	p.P2842A	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2842	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GGGTCCACCACCCCAAACCCC	0.667000													9	86					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49688109	49688109	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr3:49688109C>T	ENST00000296452.4	+	4	1697	c.1583C>T	c.(1582-1584)cCg>cTg	p.P528L		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	528					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CTAGGAGAGCCGACCCCCCTG	0.607000													4	117					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													3	39					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2806865	2806865	+	Missense_Mutation	SNP	T	T	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr8:2806865T>A	ENST00000520002.1	-	69	10916	c.10361A>T	c.(10360-10362)gAc>gTc	p.D3454V	CSMD1_ENST00000542608.1_Missense_Mutation_p.D3276V|CSMD1_ENST00000537824.1_Missense_Mutation_p.D3453V|CSMD1_ENST00000400186.3_Missense_Mutation_p.D3277V|CSMD1_ENST00000602723.1_Missense_Mutation_p.D3277V|CSMD1_ENST00000602557.1_Missense_Mutation_p.D3454V			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3454						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCCATGAATGTCACCTTGAAA	0.333000													5	24					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65792834	65792834	+	Silent	SNP	G	G	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr11:65792834G>A	ENST00000312106.5	-	1	1154	c.1017C>T	c.(1015-1017)ccC>ccT	p.P339P		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	339					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						CAGCAGGGCCGGGGGCATCGT	0.597000													9	32					0	0	1	0	0
CLCNKA	0	broad.mit.edu	37	1	16351304	16351304	+	Silent	SNP	G	G	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr1:16351304G>A	ENST00000375692.1	+	5	404	c.276G>A	c.(274-276)cgG>cgA	p.R92R	CLCNKA_ENST00000439316.2_Intron|CLCNKA_ENST00000420078.1_Silent_p.R92R|CLCNKA_ENST00000331433.4_Silent_p.R92R|CLCNKA_ENST00000464764.1_Intron			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	92					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	ACCTGCTCCGGTATCTTTCCT	0.632000													5	40					0	0	1	0	0
NXPE4	54827	broad.mit.edu	37	11	114450890	114450890	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr11:114450890G>A	ENST00000375478.3	-	5	1243	c.1063C>T	c.(1063-1065)Cgc>Tgc	p.R355C	NXPE4_ENST00000424261.2_Missense_Mutation_p.R71C	NM_001077639.1	NP_001071107.1			neurexophilin and PC-esterase domain family, member 4									p.R355C(1)									ATCCACTGGCGGATCGTGGAA	0.423000													11	123					0	0	1	0	0
AGTR1	185	broad.mit.edu	37	3	148459293	148459293	+	Silent	SNP	C	C	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr3:148459293C>A	ENST00000542281.1	+	4	917	c.471C>A	c.(469-471)ggC>ggA	p.G157G	AGTR1_ENST00000402260.1_Silent_p.G157G|AGTR1_ENST00000418473.2_Silent_p.G157G|AGTR1_ENST00000474935.1_Silent_p.G157G|AGTR1_ENST00000475347.1_Silent_p.G157G|AGTR1_ENST00000404754.2_Silent_p.G157G|AGTR1_ENST00000497524.1_Silent_p.G157G|AGTR1_ENST00000461609.1_Silent_p.G157G|AGTR1_ENST00000349243.3_Silent_p.G157G	NM_031850.3	NP_114038.4	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	157					calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	TGCTGGCAGGCTTGGCCAGTT	0.443000													6	139					0.00116845	0.00121018	1	1	0
SPATA5	166378	broad.mit.edu	37	4	123848894	123848894	+	Missense_Mutation	SNP	G	G	T			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr4:123848894G>T	ENST00000274008.3	+	2	338	c.269G>T	c.(268-270)aGt>aTt	p.S90I	SPATA5_ENST00000422835.2_3'UTR	NM_145207.2	NP_660208.2	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	90					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24						TTGCTTACTAGTTTGAACGGA	0.343000													29	58					1.13719e-10	1.19922e-10	1	1	0
BBS9	27241	broad.mit.edu	37	7	33573738	33573738	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr7:33573738G>A	ENST00000242067.6	+	21	2992	c.2471G>A	c.(2470-2472)cGt>cAt	p.R824H	BBS9_ENST00000396127.2_Missense_Mutation_p.R789H|BBS9_ENST00000350941.3_Missense_Mutation_p.R784H|BBS9_ENST00000354265.4_Missense_Mutation_p.R789H|BBS9_ENST00000355070.2_Missense_Mutation_p.R819H	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	824					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding		BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			AAAGGTGGCCGTCTCTGCCTA	0.483000									Bardet-Biedl syndrome				5	32					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17051578	17051578	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr3:17051578G>A	ENST00000418129.2	+	2	827	c.362G>A	c.(361-363)cGg>cAg	p.R121Q	PLCL2_ENST00000460467.1_3'UTR|PLCL2_ENST00000396755.2_Missense_Mutation_p.R121Q|PLCL2_ENST00000432376.1_Missense_Mutation_p.R121Q	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	247					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						ACAGGACTGCGGTACCTAATT	0.388000													6	94					0	0	1	0	0
RP11-435B5.5	0	broad.mit.edu	37	1	143391935	143391936	+	RNA	INS	-	-	TG			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr1:143391935_143391936insTG	ENST00000428624.1	+	0	2065				RP11-435B5.4_ENST00000423249.1_lincRNA																							ATATATATATATAAAGAGATTG	0.252													7	6	---	---	---	---					
STAG3L2	0	broad.mit.edu	37	7	74300803	74300804	+	RNA	INS	-	-	A			TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr7:74300803_74300804insA	ENST00000423186.1	-	0	499							P0CL84	ST3L2_HUMAN								nucleus	binding			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|pancreas(1)	5						TCTTCATACTTAAAAAAAAAAA	0.455													4	4	---	---	---	---					
CAMSAP1	157922	broad.mit.edu	37	9	138715799	138715800	+	Frame_Shift_Ins	INS	-	-	T	rs148250832	byFrequency	TCGA-YL-A9WY-01A-11D-A41K-08	TCGA-YL-A9WY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a12577d4-bd62-4861-8ff9-5a105aefd37d	f34aa0a2-b38e-4ace-9e89-354122af4010	g.chr9:138715799_138715800insT	ENST00000389532.4	-	10	1460_1461	c.1396_1397insA	c.(1396-1398)cagfs	p.Q466fs	CAMSAP1_ENST00000409386.3_Frame_Shift_Ins_p.Q477fs|CAMSAP1_ENST00000483991.1_5'UTR|CAMSAP1_ENST00000312405.6_Frame_Shift_Ins_p.Q188fs	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	466						cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GACTCACCTGGTTTTTTTTTCT	0.460													3	5	---	---	---	---