Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KMT2C	58508	broad.mit.edu	37	7	151860195	151860195	+	Silent	SNP	T	T	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr7:151860195T>C	ENST00000355193.2	-	43	10685	c.10467A>G	c.(10465-10467)caA>caG	p.Q3489Q	KMT2C_ENST00000262189.6_Silent_p.Q3489Q					lysine (K)-specific methyltransferase 2C																		TTGATCCTTGTTGTATATTCT	0.463000													28	96					0	0	1	0	0
ATG14	22863	broad.mit.edu	37	14	55844786	55844786	+	Silent	SNP	A	A	G			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr14:55844786A>G	ENST00000247178.5	-	8	1037	c.1002T>C	c.(1000-1002)ttT>ttC	p.F334F		NM_014924.4	NP_055739.2	Q6ZNE5	BAKOR_HUMAN	autophagy related 14	334					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(2)	13						TTTCGCCACAAAATTCACTGT	0.289000													8	34					0	0	1	0	0
CP	1356	broad.mit.edu	37	3	148916153	148916153	+	Splice_Site	SNP	C	C	G			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr3:148916153C>G	ENST00000264613.6	-	9	1976		c.e9+1		CP_ENST00000462336.1_Splice_Site	NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)						cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	GTTGGACTTACCTGTCTCCCA	0.338000													13	32					0	0	1	0	0
GLOD4	51031	broad.mit.edu	37	17	663460	663460	+	Missense_Mutation	SNP	T	T	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr17:663460T>A	ENST00000301329.6	-	9	935	c.850A>T	c.(850-852)Agt>Tgt	p.S284C	GLOD4_ENST00000536578.1_Missense_Mutation_p.S275C|GLOD4_ENST00000301328.5_Missense_Mutation_p.S299C	NM_016080.3	NP_057164.3	Q9HC38	GLOD4_HUMAN	glyoxalase domain containing 4	299						mitochondrion				endometrium(1)|large_intestine(1)|prostate(1)	3				UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		CACTCGTCACTTTTATCTGCT	0.428000													18	48					0	0	1	0	0
WDR77	79084	broad.mit.edu	37	1	111983955	111983955	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr1:111983955T>C	ENST00000235090.5	-	10	1132	c.926A>G	c.(925-927)aAt>aGt	p.N309S	WDR77_ENST00000497278.1_5'UTR|WDR77_ENST00000411751.2_Missense_Mutation_p.N245S	NM_024102.2	NP_077007.1	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	309					ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		CAGGGAGTGATTGAGCGGGGA	0.532000													13	43					0	0	1	0	0
ORMDL2	29095	broad.mit.edu	37	12	56213247	56213247	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr12:56213247G>A	ENST00000243045.5	+	3	491	c.296G>A	c.(295-297)cGc>cAc	p.R99H	ORMDL2_ENST00000550836.1_Missense_Mutation_p.R11H|RP11-762I7.5_ENST00000546837.1_Intron|ORMDL2_ENST00000552672.1_Missense_Mutation_p.R65H|ORMDL2_ENST00000548974.1_Missense_Mutation_p.R99H|RP11-762I7.5_ENST00000552719.1_Intron	NM_014182.4	NP_054901.1	Q53FV1	ORML2_HUMAN	ORM1-like 2 (S. cerevisiae)	99					ceramide metabolic process	endoplasmic reticulum membrane|integral to membrane				kidney(1)|lung(3)	4						ACCTCTTCCCGCAAGTTCCTC	0.512000													4	129					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33652628	33652628	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr6:33652628G>C	ENST00000374316.5	+	40	6275	c.5215G>C	c.(5215-5217)Gac>Cac	p.D1739H	ITPR3_ENST00000605930.1_Missense_Mutation_p.D1739H			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	1739					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						GTTGGTATGCGACCTCATCAC	0.627000													13	54					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23914995	23914995	+	Missense_Mutation	SNP	T	T	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr13:23914995T>A	ENST00000382298.3	-	10	3608	c.3020A>T	c.(3019-3021)gAa>gTa	p.E1007V	SACS_ENST00000402364.1_Missense_Mutation_p.E257V|SACS_ENST00000382292.3_Missense_Mutation_p.E1007V	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1007					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TGTTACCTCTTCATGTGAATA	0.328000													29	100					0	0	1	0	0
RASGEF1C	255426	broad.mit.edu	37	5	179545631	179545631	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr5:179545631G>A	ENST00000393371.2	-	9	1357	c.1061C>T	c.(1060-1062)aCg>aTg	p.T354M	RASGEF1C_ENST00000522500.1_Missense_Mutation_p.T203M|RASGEF1C_ENST00000361132.4_Missense_Mutation_p.T354M			Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	354	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	12	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTGTGGGCCGTCAGGGAGCG	0.662000													25	46					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46658755	46658755	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr6:46658755A>C	ENST00000544460.1	+	1	3144	c.2890A>C	c.(2890-2892)Aag>Cag	p.K964Q	TDRD6_ENST00000316081.6_Missense_Mutation_p.K964Q	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	964					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			AAAACTTCAGAAGCCTTTGGA	0.363000													25	58					0	0	1	0	0
RBFOX1	54715	broad.mit.edu	37	16	7568326	7568326	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr16:7568326G>A	ENST00000340209.4	+	2	517	c.220G>A	c.(220-222)Gcc>Acc	p.A74T	RBFOX1_ENST00000311745.5_Missense_Mutation_p.A89T|RBFOX1_ENST00000547338.1_Missense_Mutation_p.A69T|RBFOX1_ENST00000436368.2_Missense_Mutation_p.A89T|RBFOX1_ENST00000422070.4_Missense_Mutation_p.A112T|RBFOX1_ENST00000553186.1_Missense_Mutation_p.A69T|RBFOX1_ENST00000547372.1_Missense_Mutation_p.A112T|RBFOX1_ENST00000535565.2_Missense_Mutation_p.A105T|RBFOX1_ENST00000550418.1_Missense_Mutation_p.A69T|RBFOX1_ENST00000355637.4_Missense_Mutation_p.A89T|RBFOX1_ENST00000552089.1_Missense_Mutation_p.A105T			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	69					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding	p.A89T(2)		breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						GTACCCTCCCGCCCAGACGCA	0.642000													36	103					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4876196	4876196	+	Silent	SNP	C	C	T			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr7:4876196C>T	ENST00000399583.3	-	3	763	c.576G>A	c.(574-576)gcG>gcA	p.A192A	RADIL_ENST00000538469.1_5'UTR|RADIL_ENST00000536091.1_Silent_p.A192A	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	192					cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GGGTTCCCTTCGCGCGACTCC	0.657000													3	18					0	0	1	0	0
FABP6	2172	broad.mit.edu	37	5	159656578	159656578	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr5:159656578G>A	ENST00000393980.4	+	4	307	c.161G>A	c.(160-162)gGc>gAc	p.G54D	FABP6_ENST00000393982.1_Missense_Mutation_p.G54D|FABP6_ENST00000402432.3_Missense_Mutation_p.G5D	NM_001130958.1	NP_001124430.1	P51161	FABP6_HUMAN	fatty acid binding protein 6, ileal	5					bile acid and bile salt transport|bile acid metabolic process|negative regulation of cell proliferation	cytosol	transporter activity	p.G54D(1)|p.G5D(1)		breast(1)|kidney(1)|large_intestine(1)|lung(2)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCTTTCACCGGCAAGTTCGAG	0.537000													5	146					0	0	1	0	0
APRT	353	broad.mit.edu	37	16	88878005	88878005	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr16:88878005G>C	ENST00000378364.3	-	2	184	c.140C>G	c.(139-141)gCg>gGg	p.A47G	APRT_ENST00000563655.1_Missense_Mutation_p.A47G|APRT_ENST00000426324.2_Missense_Mutation_p.A47G	NM_000485.2	NP_000476.1	P07741	APT_HUMAN	adenine phosphoribosyltransferase	47					purine ribonucleoside salvage	cytosol|nucleus	adenine phosphoribosyltransferase activity|AMP binding|protein binding			cervix(1)|endometrium(1)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(80;0.0477)	Adenine(DB00173)|Adenosine monophosphate(DB00131)	CAGGTGTCGCGCCAGGAGGCC	0.721000													4	7					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100676777	100676777	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr7:100676777C>T	ENST00000306151.4	+	3	2144	c.2080C>T	c.(2080-2082)Cct>Tct	p.P694S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	694	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.P694S(1)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACAAGTATGCCTGTCAACAC	0.493000													5	349					0	0	1	0	0
RHOU	58480	broad.mit.edu	37	1	228871654	228871654	+	Silent	SNP	C	C	T			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr1:228871654C>T	ENST00000366691.3	+	1	831	c.165C>T	c.(163-165)gtC>gtT	p.V55V		NM_021205.5	NP_067028.1	Q7L0Q8	RHOU_HUMAN	ras homolog family member U	55	Gly-rich.				regulation of small GTPase mediated signal transduction	cell projection|cytosol|focal adhesion|Golgi membrane|podosome	GTP binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|stomach(1)	13	Breast(184;0.162)	Prostate(94;0.183)				GCGTGCTGGTCGGCGACGGCG	0.736000													11	9					0	0	1	0	0
DDX6	1656	broad.mit.edu	37	11	118635928	118635928	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr11:118635928A>C	ENST00000264018.4	-	6	940	c.635T>G	c.(634-636)cTt>cGt	p.L212R	DDX6_ENST00000534980.1_Missense_Mutation_p.L212R|DDX6_ENST00000526070.2_Missense_Mutation_p.L212R	NM_004397.4	NP_004388.2	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 6	212	Helicase ATP-binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	13	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		TGTATCATCAAGCCTCATTAT	0.368000			T	IGH@	B-NHL								62	166					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100679721	100679721	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr7:100679721C>A	ENST00000306151.4	+	3	5088	c.5024C>A	c.(5023-5025)gCt>gAt	p.A1675D		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1675	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTACACCTGCTGAAGGTACC	0.493000													61	186					9.53615e-21	1.13072e-20	1	1	0
FNIP1	96459	broad.mit.edu	37	5	131008040	131008040	+	Silent	SNP	T	T	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr5:131008040T>C	ENST00000307968.7	-	13	2012	c.2013A>G	c.(2011-2013)ttA>ttG	p.L671L	FNIP1_ENST00000510461.1_Silent_p.L699L|FNIP1_ENST00000307954.8_Silent_p.L654L|FNIP1_ENST00000514667.1_Intron	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		CTGTTGACTCTAAGCCTGACT	0.428000													56	148					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24990954	24990954	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr2:24990954A>C	ENST00000405141.1	+	24	4873	c.4162A>C	c.(4162-4164)Aag>Cag	p.K1388Q	NCOA1_ENST00000395856.3_Intron|NCOA1_ENST00000538539.1_Missense_Mutation_p.K1388Q|NCOA1_ENST00000407230.1_Missense_Mutation_p.K1237Q|NCOA1_ENST00000348332.3_Intron|NCOA1_ENST00000406961.1_Intron|NCOA1_ENST00000288599.5_Missense_Mutation_p.K1388Q			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	1388									PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTAGGACAAGAAGACAGAAGA	0.438000			T	PAX3	alveolar rhadomyosarcoma								31	97					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140481405	140481405	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr7:140481405A>C	ENST00000288602.6	-	11	1463	c.1403T>G	c.(1402-1404)tTt>tGt	p.F468C		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	468	Protein kinase.		F -> S (in CFC syndrome).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.F468S(1)|p.F468C(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	GACTGTTCCAAATGATCCAGA	0.378000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				12	57					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883123	228883123	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr2:228883123C>T	ENST00000392056.3	-	7	2493	c.2447G>A	c.(2446-2448)cGt>cAt	p.R816H	SPHKAP_ENST00000344657.5_Missense_Mutation_p.R816H	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	816						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TCTGTGACTACGTGATAATTG	0.458000													94	255					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91827401	91827401	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr15:91827401A>G	ENST00000394232.1	+	11	2128	c.1658A>G	c.(1657-1659)aAc>aGc	p.N553S	SV2B_ENST00000545111.2_Missense_Mutation_p.N402S|SV2B_ENST00000330276.4_Missense_Mutation_p.N553S	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	553					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			TTACCCGGGAACATCATTTCT	0.537000													22	85					0	0	1	0	0
IRF2BPL	64207	broad.mit.edu	37	14	77492213	77492213	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr14:77492213C>A	ENST00000238647.3	-	1	2821	c.1923G>T	c.(1921-1923)aaG>aaT	p.K641N		NM_024496.3	NP_078772.1	Q9H1B7	I2BPL_HUMAN	interferon regulatory factor 2 binding protein-like	641						nucleus				endometrium(2)|kidney(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	11						AACTGCCATCCTTGGGCGAGT	0.682000													7	26					0.00198382	0.00208426	1	1	0
FBN3	84467	broad.mit.edu	37	19	8175963	8175963	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr19:8175963C>T	ENST00000600128.1	-	33	4603	c.4189G>A	c.(4189-4191)Gag>Aag	p.E1397K	FBN3_ENST00000601739.1_Missense_Mutation_p.E1397K|FBN3_ENST00000270509.2_Missense_Mutation_p.E1397K			Q75N90	FBN3_HUMAN	fibrillin 3	1397	EGF-like 21; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CGGTGGTCCTCGGTGGGGTCA	0.657000													13	11					0	0	1	0	0
ZFAND4	93550	broad.mit.edu	37	10	46113586	46113586	+	Splice_Site	SNP	G	G	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr10:46113586G>C	ENST00000374366.3	-	10	2292		c.e10+1		ZFAND4_ENST00000374370.1_Splice_Site|ZFAND4_ENST00000374371.2_Splice_Site|ZFAND4_ENST00000344646.5_Splice_Site			Q86XD8	ANUB1_HUMAN	zinc finger, AN1-type domain 4								zinc ion binding										TCGCCAACCTGCCTGCATTCG	0.408000													12	29					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871022	170871022	+	Silent	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr6:170871022G>A	ENST00000392092.2	+	3	477	c.198G>A	c.(196-198)caG>caA	p.Q66Q	TBP_ENST00000540980.1_Silent_p.Q46Q|TBP_ENST00000230354.6_Silent_p.Q66Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	66	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		aacagcagcagcagcagcagc	0.562000													8	34					0	0	1	0	0
BTG3	10950	broad.mit.edu	37	21	18966461	18966461	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr21:18966461G>A	ENST00000339775.6	-	6	994	c.841C>T	c.(841-843)Cat>Tat	p.H281Y	BTG3_ENST00000348354.6_Missense_Mutation_p.H237Y	NM_001130914.1	NP_001124386.1	Q14201	BTG3_HUMAN	BTG family, member 3	237					negative regulation of cell proliferation|negative regulation of mitotic cell cycle	cytoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)	8				Epithelial(23;0.000283)|all cancers(11;0.0012)|Lung(58;0.0191)|OV - Ovarian serous cystadenocarcinoma(11;0.0206)|COAD - Colon adenocarcinoma(22;0.0315)|LUSC - Lung squamous cell carcinoma(23;0.0703)|Colorectal(24;0.0971)		CGGTCACAATGCATTCCAGGA	0.413000													22	55					0	0	1	0	0
GH1	2688	broad.mit.edu	37	17	61995198	61995198	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr17:61995198G>T	ENST00000323322.5	-	4	420	c.378C>A	c.(376-378)agC>agA	p.S126R	GH1_ENST00000342364.4_Intron|CSHL1_ENST00000392824.4_Intron|GH1_ENST00000351388.4_Missense_Mutation_p.S86R|GH1_ENST00000458650.2_Missense_Mutation_p.S111R	NM_000515.3	NP_000506.2	P01241	SOMA_HUMAN	growth hormone 1	126					glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	19						CGTACACCAGGCTGTTGGCGA	0.612000													20	65					8.00594e-06	8.74333e-06	1	1	0
PSG3	5671	broad.mit.edu	37	19	43244510	43244510	+	Silent	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr19:43244510G>A	ENST00000327495.5	-	1	211	c.27C>T	c.(25-27)tgC>tgT	p.C9C	PSG3_ENST00000595140.1_Silent_p.C9C	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	9					defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				TGCGCTGTGTGCAGGGAGGGG	0.607000													44	113					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1639732	1639732	+	Silent	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr16:1639732G>A	ENST00000426508.2	-	7	1047	c.684C>T	c.(682-684)tcC>tcT	p.S228S	LA16c-395F10.2_ENST00000563162.1_RNA|IFT140_ENST00000439987.2_5'UTR	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	228										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				TGCTGTCTGCGGACACCACCT	0.567000													18	35					0	0	1	0	0
MARK1	4139	broad.mit.edu	37	1	220791998	220791998	+	Silent	SNP	A	A	G			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr1:220791998A>G	ENST00000402574.1	+	9	1407	c.405A>G	c.(403-405)ttA>ttG	p.L135L	MARK1_ENST00000366917.4_Silent_p.L270L|MARK1_ENST00000366918.4_Silent_p.L248L	NM_018650.3	NP_061120.3	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	270	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		AGCGAGTTTTACGAGGGAAGT	0.353000													23	36					0	0	1	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87452473	87452473	+	Silent	SNP	G	G	C	rs141236185		TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr16:87452473G>C	ENST00000268616.4	-	7	886	c.669C>G	c.(667-669)acC>acG	p.T223T		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	223					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		CGCCCATCACGGTACCTACTT	0.323000													13	27					0	0	1	0	0
NOA1	84273	broad.mit.edu	37	4	57842862	57842862	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr4:57842862C>A	ENST00000264230.4	-	1	2127	c.890G>T	c.(889-891)gGg>gTg	p.G297V		NM_032313.2	NP_115689.1	Q8NC60	CD014_HUMAN	nitric oxide associated 1	297							GTP binding										CGGATTCTCCCCGTCCTGTGG	0.677000													4	29					0.000157383	0.000169647	1	1	0
PAK6	56924	broad.mit.edu	37	15	40558520	40558520	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr15:40558520C>T	ENST00000455577.2	+	5	1594	c.682C>T	c.(682-684)Cgg>Tgg	p.R228W	PAK6_ENST00000560346.1_Missense_Mutation_p.R228W|PAK6_ENST00000542403.2_Missense_Mutation_p.R228W|RP11-133K1.2_ENST00000558658.1_3'UTR|PAK6_ENST00000559901.1_3'UTR|PAK6_ENST00000260404.4_Missense_Mutation_p.R228W|PAK6_ENST00000453867.1_Missense_Mutation_p.R228W|PAK6_ENST00000441369.1_Missense_Mutation_p.R228W	NM_001276718.1	NP_001263647.1	Q9NQU5	PAK6_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 6	228	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(2)	24		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		TGAGGAGGCCCGGCCACAGTC	0.672000													6	15					0	0	1	0	0
ARHGAP15	55843	broad.mit.edu	37	2	144381721	144381721	+	Silent	SNP	C	C	T	rs138120208		TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr2:144381721C>T	ENST00000295095.6	+	12	1190	c.1023C>T	c.(1021-1023)gaC>gaT	p.D341D		NM_018460.3	NP_060930.3	Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15	341	Rho-GAP.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		TGAATTTGGACGACAGCCAGT	0.448000													19	54					0	0	1	0	0
LINC00173	0	broad.mit.edu	37	12	116972454	116972454	+	RNA	SNP	C	C	G			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr12:116972454C>G	ENST00000480237.1	+	0	725					NR_027345.1																						CCGTACAGCACGATGATTACA	0.448000													13	57					0	0	1	0	0
SF3B3	23450	broad.mit.edu	37	16	70602298	70602298	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr16:70602298T>C	ENST00000302516.5	+	22	3276	c.3065T>C	c.(3064-3066)aTc>aCc	p.I1022T		NM_012426.4	NP_036558.3	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3, 130kDa	1022					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(2)|endometrium(8)|kidney(2)|large_intestine(8)|liver(3)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	53		Ovarian(137;0.0694)				AACCAGCTTATCATCTTTGCT	0.468000													28	66					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29632688	29632688	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr20:29632688A>G	ENST00000278882.3	+	8	883	c.503A>G	c.(502-504)aAa>aGa	p.K168R	FRG1B_ENST00000358464.4_Missense_Mutation_p.K168R																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AAGGCTCAGAAAGATGGATTT	0.318000													23	604					0	0	1	0	0
TANK	10010	broad.mit.edu	37	2	162091959	162091959	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr2:162091959T>C	ENST00000392749.2	+	8	1447	c.1208T>C	c.(1207-1209)tTc>tCc	p.F403S	AC009299.2_ENST00000445372.1_RNA|TANK_ENST00000405852.1_3'UTR|TANK_ENST00000259075.2_Missense_Mutation_p.F403S|AC009299.2_ENST00000421122.2_RNA	NM_001199135.1	NP_001186064.1	Q92844	TANK_HUMAN	TRAF family member-associated NFKB activator	403						cytosol	metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)	21						CAAGCAGTTTTCCCACCATCC	0.433000													30	71					0	0	1	0	0
TMCO3	55002	broad.mit.edu	37	13	114203965	114203965	+	Silent	SNP	C	C	G			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr13:114203965C>G	ENST00000375391.1	+	8	1553	c.1242C>G	c.(1240-1242)ctC>ctG	p.L414L	TMCO3_ENST00000434316.2_3'UTR			Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	0						integral to membrane	solute:hydrogen antiporter activity			NS(1)|endometrium(4)|large_intestine(9)|liver(1)|lung(8)|prostate(1)|stomach(1)	25	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			GAACAGCCCTCTAGCAGAGCG	0.498000													4	13					0	0	1	0	0
ERCC2	2068	broad.mit.edu	37	19	45856355	45856355	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr19:45856355T>C	ENST00000391945.4	-	19	1894	c.1817A>G	c.(1816-1818)gAg>gGg	p.E606G	ERCC2_ENST00000391944.3_Missense_Mutation_p.E528G	NM_000400.3	NP_000391.1	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 2	606	Mediates interaction with MMS19.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GTCGATTCCCTCGGACACTTT	0.642000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				19	40					0	0	1	0	0
KIRREL3	84623	broad.mit.edu	37	11	126326257	126326257	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr11:126326257C>A	ENST00000525144.2	-	7	1084	c.835G>T	c.(835-837)Gtc>Ttc	p.V279F	KIRREL3_ENST00000529097.2_Missense_Mutation_p.V279F|KIRREL3_ENST00000525704.2_Missense_Mutation_p.V279F	NM_032531.3	NP_115920.1	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 (Drosophila)	279	Ig-like C2-type 3.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|endometrium(5)|large_intestine(11)|lung(8)|ovary(3)|prostate(1)	29	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		TACTGGGTGACAGCTGGGTTG	0.642000													3	10					0.004672	0.0048472	1	1	0
GLE1	2733	broad.mit.edu	37	9	131296231	131296231	+	Splice_Site	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr9:131296231G>A	ENST00000309971.4	+	11	1752		c.e11+1		GLE1_ENST00000372770.4_Splice_Site|RP11-216B9.6_ENST00000434999.1_RNA|GLE1_ENST00000539582.1_Splice_Site	NM_001003722.1	NP_001003722.1	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator						poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	16						ACTATCAGAGGTAAAGTTGTT	0.398000													24	43					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	107914363	107914363	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr12:107914363C>A	ENST00000280758.5	+	2	1763	c.1235C>A	c.(1234-1236)aCc>aAc	p.T412N	BTBD11_ENST00000490090.2_Missense_Mutation_p.T412N|BTBD11_ENST00000420571.2_Missense_Mutation_p.T412N	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	412						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						GAGCTGAGGACCATCGAGCAG	0.562000													13	52					1.15088e-07	1.29085e-07	1	1	0
ZNF571	51276	broad.mit.edu	37	19	38056575	38056575	+	Missense_Mutation	SNP	T	T	G			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr19:38056575T>G	ENST00000328550.2	-	4	854	c.755A>C	c.(754-756)gAa>gCa	p.E252A	ZNF571_ENST00000590751.1_Intron|ZNF571-AS1_ENST00000586013.1_RNA|ZNF571-AS1_ENST00000587121.1_RNA|ZNF571_ENST00000451802.2_Missense_Mutation_p.E252A|ZNF571-AS1_ENST00000590838.1_RNA|ZNF571-AS1_ENST00000589750.1_RNA|ZNF571-AS1_ENST00000585578.1_RNA|ZNF540_ENST00000592533.1_Intron|ZNF571-AS1_ENST00000592392.1_RNA|ZNF571_ENST00000358744.3_Missense_Mutation_p.E252A|ZNF571-AS1_ENST00000586139.1_RNA|ZNF571-AS1_ENST00000589802.1_RNA|ZNF571-AS1_ENST00000591430.1_RNA|ZNF571_ENST00000593133.1_Missense_Mutation_p.E252A			Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	252			E -> D (in dbSNP:rs28512414).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	25			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTCTTACATTCATATGGTTT	0.368000													14	22					0	0	1	0	0
C1RL	51279	broad.mit.edu	37	12	7254578	7254578	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr12:7254578G>A	ENST00000266542.4	-	3	498	c.406C>T	c.(406-408)Cgg>Tgg	p.R136W	C1RL_ENST00000545280.1_Intron|C1RL_ENST00000545337.1_Missense_Mutation_p.R136W|C1RL_ENST00000544702.1_Missense_Mutation_p.R136W	NM_016546.2	NP_057630.2	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	136	CUB.				complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						AAGGTCAGCCGCAAACTCCTC	0.607000													4	130					0	0	1	0	0
CHD6	0	broad.mit.edu	37	20	40126084	40126084	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr20:40126084G>C	ENST00000373233.3	-	8	1209	c.1032C>G	c.(1030-1032)atC>atG	p.I344M	CHD6_ENST00000373222.3_3'UTR|CHD6_ENST00000309279.7_Missense_Mutation_p.I344M	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	344					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TCTTCTGTGCGATGCGAGGAT	0.413000													22	83					0	0	1	0	0
TLR5	7100	broad.mit.edu	37	1	223284141	223284141	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr1:223284141G>T	ENST00000540964.1	-	4	2694	c.2233C>A	c.(2233-2235)Cag>Aag	p.Q745K	TLR5_ENST00000342210.6_Missense_Mutation_p.Q745K			O60602	TLR5_HUMAN	toll-like receptor 5	745	TIR.		Missing (in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1).		cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		ATGGCATCCTGGATATTGGCA	0.473000													3	21					0.115264	0.11811	1	1	0
ADAM23	8745	broad.mit.edu	37	2	207414876	207414876	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr2:207414876C>G	ENST00000264377.3	+	9	1253	c.925C>G	c.(925-927)Cac>Gac	p.H309D	ADAM23_ENST00000374415.3_Missense_Mutation_p.H309D|ADAM23_ENST00000374416.1_Missense_Mutation_p.H309D	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	309	Peptidase M12B.				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TGTTAATGATCACAAAACGGT	0.269000													10	24					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394212	233394212	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr1:233394212G>A	ENST00000258229.8	-	5	1630	c.1396C>T	c.(1396-1398)Cag>Tag	p.Q466*	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	466						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				CCAGAACACTGATTGGTGGAT	0.572000													11	11					0	0	1	0	0
GAP43	2596	broad.mit.edu	37	3	115394932	115394932	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr3:115394932G>A	ENST00000393780.3	+	3	679	c.211G>A	c.(211-213)Gca>Aca	p.A71T	GAP43_ENST00000305124.6_Missense_Mutation_p.A35T	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	35					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		TCATAAGGCCGCAACCAAAAT	0.408000													12	51					0	0	1	0	0
SLC17A8	246213	broad.mit.edu	37	12	100811862	100811862	+	Silent	SNP	G	G	T	rs145178639	byFrequency	TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr12:100811862G>T	ENST00000323346.5	+	11	1666	c.1353G>T	c.(1351-1353)ggG>ggT	p.G451G	SLC17A8_ENST00000552697.1_3'UTR|SLC17A8_ENST00000392989.3_Silent_p.G401G	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	451					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						TTCTCATGGGGATCTCAAACG	0.488000													25	103					1.42536e-11	1.64312e-11	1	1	0
DCN	1634	broad.mit.edu	37	12	91572146	91572146	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr12:91572146G>T	ENST00000551354.1	-	2	388	c.184C>A	c.(184-186)Ctt>Att	p.L62I	DCN_ENST00000441303.2_Missense_Mutation_p.L62I|DCN_ENST00000550099.1_Missense_Mutation_p.L62I|DCN_ENST00000552962.1_Missense_Mutation_p.L62I|DCN_ENST00000420120.2_Missense_Mutation_p.L62I|DCN_ENST00000546370.1_Missense_Mutation_p.L62I|DCN_ENST00000393155.1_Missense_Mutation_p.L62I|DCN_ENST00000303320.3_Missense_Mutation_p.L62I|DCN_ENST00000425043.1_Missense_Mutation_p.L62I|DCN_ENST00000052754.5_Missense_Mutation_p.L62I|DCN_ENST00000228329.5_Missense_Mutation_p.L62I|DCN_ENST00000456569.2_Missense_Mutation_p.L62I|DCN_ENST00000547568.2_Missense_Mutation_p.L62I|DCN_ENST00000546745.1_Missense_Mutation_p.L62I			P07585	PGS2_HUMAN	decorin	62	Cys-rich.				organ morphogenesis	extracellular space				central_nervous_system(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|skin(1)	20						ACCACTCGAAGATGGCATTGA	0.512000											OREG0022021	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	58					6.36457e-07	7.04346e-07	1	1	0
DHRS7C	201140	broad.mit.edu	37	17	9676090	9676090	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr17:9676090A>G	ENST00000330255.4	-	5	736	c.724T>C	c.(724-726)Tgg>Cgg	p.W242R	DHRS7C_ENST00000571134.1_Missense_Mutation_p.W241R	NM_001220493.1	NP_001207422.1	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	242						extracellular region	binding|oxidoreductase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	15						TCACATTTCCAAATGGAAGCT	0.557000													9	36					0	0	1	0	0
PFKP	5214	broad.mit.edu	37	10	3177927	3177927	+	Splice_Site	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr10:3177927G>A	ENST00000381075.2	+	23	2322		c.e23-1		PFKP_ENST00000381125.4_Splice_Site|PFKP_ENST00000381072.1_Splice_Site	NM_001242339.1	NP_001229268.1	Q01813	K6PP_HUMAN	phosphofructokinase, platelet						glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		ATCTTTTATAGGAAAAAAATT	0.408000													11	44					0	0	1	0	0
MYOT	9499	broad.mit.edu	37	5	137219277	137219277	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr5:137219277C>A	ENST00000239926.4	+	7	1395	c.1021C>A	c.(1021-1023)Ctt>Att	p.L341I	MYOT_ENST00000421631.2_Missense_Mutation_p.L157I|MYOT_ENST00000515645.1_Missense_Mutation_p.L226I|MYOT_ENST00000509812.1_Intron|RP11-381K20.2_ENST00000514616.1_RNA|RP11-381K20.2_ENST00000508281.2_RNA	NM_006790.2	NP_006781.1	Q9UBF9	MYOTI_HUMAN	myotilin	341	Necessary for interaction with ACTA1.|Necessary for interaction with FLNC.				muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			cervix(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GCTGGATGTCCTTGGTAAGCC	0.413000													3	28					0.150653	0.152491	1	1	0
DENND6B	414918	broad.mit.edu	37	22	50754487	50754487	+	Silent	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr22:50754487G>A	ENST00000413817.2	-	8	740	c.669C>T	c.(667-669)tcC>tcT	p.S223S		NM_001001794.3	NP_001001794.3			DENN/MADD domain containing 6B																		GACTGGACTCGGACTTGTCCA	0.627000													33	87					0	0	1	0	0
IFITM3	10410	broad.mit.edu	37	11	320606	320606	+	Missense_Mutation	SNP	G	G	T	rs149004156	by1000genomes	TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr11:320606G>T	ENST00000399808.4	-	1	444	c.208C>A	c.(208-210)Ccc>Acc	p.P70T	IFITM3_ENST00000602735.1_Missense_Mutation_p.P49T|RP11-326C3.11_ENST00000602756.1_RNA|RP11-326C3.11_ENST00000602429.1_RNA|IFITM3_ENST00000526811.1_Missense_Mutation_p.P49T	NM_021034.2	NP_066362.2	Q01628	IFM3_HUMAN	interferon induced transmembrane protein 3	70	Interaction with SPP1.				response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane		p.P70T(3)		central_nervous_system(7)|endometrium(7)|kidney(2)|large_intestine(1)|lung(1)	18		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		AGGCAGCAGGGGTTCATGAAG	0.632000													5	96					4.68919e-08	5.33154e-08	1	1	0
TCEAL8	90843	broad.mit.edu	37	X	102508606	102508606	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chrX:102508606C>T	ENST00000372685.3	-	3	538	c.302G>A	c.(301-303)tGg>tAg	p.W101*	TCEAL8_ENST00000360000.4_Nonsense_Mutation_p.W101*	NM_153333.2	NP_699164.1	Q8IYN2	TCAL8_HUMAN	transcription elongation factor A (SII)-like 8	101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				kidney(2)|lung(1)|ovary(1)	4						TCTTTGCTTCCAATGCATCAT	0.408000													28	25					0	0	1	0	0
GAD1	2571	broad.mit.edu	37	2	171700581	171700581	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr2:171700581T>C	ENST00000358196.3	+	7	1215	c.665T>C	c.(664-666)tTt>tCt	p.F222S	GAD1_ENST00000429023.1_3'UTR	NM_000817.2	NP_000808.2	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 (brain, 67kDa)	222					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(15)|ovary(1)|urinary_tract(2)	35					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GCACCAGTGTTTGTCCTCATG	0.368000													9	22					0	0	1	0	0
ZBTB7B	51043	broad.mit.edu	37	1	154988264	154988264	+	Silent	SNP	C	C	T			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr1:154988264C>T	ENST00000368426.3	+	3	1265	c.1128C>T	c.(1126-1128)tgC>tgT	p.C376C	ZBTB7B_ENST00000292176.2_Silent_p.C376C|ZBTB7B_ENST00000417934.2_Silent_p.C410C|ZBTB7B_ENST00000535420.1_Silent_p.C376C	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	376					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CCTTTGCCTGCGAGGTCTGCG	0.627000													10	39					0	0	1	0	0
HSCB	150274	broad.mit.edu	37	22	29141932	29141932	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr22:29141932C>G	ENST00000216027.3	+	4	569	c.504C>G	c.(502-504)atC>atG	p.I168M	HSCB_ENST00000495977.1_3'UTR|HSCB_ENST00000398941.2_Intron	NM_172002.3	NP_741999.3	Q8IWL3	HSC20_HUMAN	HscB mitochondrial iron-sulfur cluster co-chaperone	168					iron-sulfur cluster assembly|protein folding	mitochondrion	chaperone binding|heat shock protein binding|metal ion binding			kidney(1)|lung(2)|skin(1)	4						TAATGGAAATCAATGAAAAAC	0.373000													15	44					0	0	1	0	0
SPOP	8405	broad.mit.edu	37	17	47696424	47696424	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr17:47696424G>T	ENST00000393331.3	-	7	869	c.399C>A	c.(397-399)ttC>ttA	p.F133L	SPOP_ENST00000347630.2_Missense_Mutation_p.F133L|SPOP_ENST00000503676.1_Missense_Mutation_p.F133L|SPOP_ENST00000504102.1_Missense_Mutation_p.F133L|SPOP_ENST00000393328.2_Missense_Mutation_p.F133L	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	133	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding	p.F133L(7)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						TGAATTTCTTGAATCCCCAGT	0.448000										Prostate(2;0.17)			36	87					2.26627e-22	2.7261e-22	1	1	0
FAM83B	222584	broad.mit.edu	37	6	54806506	54806506	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr6:54806506A>G	ENST00000306858.7	+	5	2853	c.2737A>G	c.(2737-2739)Act>Gct	p.T913A		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	913										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					AAGAAGACCTACTTCTTCTCC	0.463000													20	45					0	0	1	0	0
PCDHA12	0	broad.mit.edu	37	5	140256423	140256423	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr5:140256423G>A	ENST00000398631.2	+	1	1366	c.1366G>A	c.(1366-1368)Gcg>Acg	p.A456T	PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1												p.A456T(1)		NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCTGCGTTCGCGCAGCCCGA	0.662000													36	114					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156819190	156819190	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr1:156819190G>A	ENST00000368195.3	-	6	1688	c.1292C>T	c.(1291-1293)gCg>gTg	p.A431V	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	431					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGTGAGCCCCGCGGCCACCCA	0.622000													14	49					0	0	1	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204199577	204199578	+	Frame_Shift_Ins	INS	-	-	G	rs139335539	byFrequency	TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr1:204199577_204199578insG	ENST00000272203.3	-	18	2862_2863	c.2546_2547insC	c.(2545-2547)cgcfs	p.R849fs	PLEKHA6_ENST00000414478.1_Frame_Shift_Ins_p.R869fs	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	849										breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GGTCGGGGGCCGGGCTGGCCGG	0.653													2	4	---	---	---	---					
IFT172	26160	broad.mit.edu	37	2	27680743	27680756	+	Frame_Shift_Del	DEL	CTGGATGGTGCTTC	CTGGATGGTGCTTC	-	rs61747068	byFrequency	TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr2:27680743_27680756delCTGGATGGTGCTTC	ENST00000260570.3	-	28	3166_3179	c.3063_3076delGAAGCACCATCCAG	c.(3061-3078)ggatfs	p.GKHHPD1021fs		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	1021					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					CTGAGGAGATCTGGATGGTGCTTCCCTACCAGGC	0.514													9	56	---	---	---	---					
RP11-680B3.2	0	broad.mit.edu	37	3	148582960	148582960	+	RNA	DEL	A	A	-	rs143382113		TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr3:148582960delA	ENST00000488190.1	-	0	304																											CTCCAGCTGGAAAAAAAAAAC	0.438													3	4	---	---	---	---					
HIST1H2AC	8334	broad.mit.edu	37	6	26124602	26124616	+	In_Frame_Del	DEL	GCGCCGGTGTACCTG	GCGCCGGTGTACCTG	-	rs139293879		TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr6:26124602_26124616delGCGCCGGTGTACCTG	ENST00000602637.1	+	1	172_186	c.142_156delGCGCCGGTGTACCTG	c.(142-156)del	p.APVYL48del	HIST1H2AC_ENST00000377791.2_In_Frame_Del_p.APVYL48del			Q93077	H2A1C_HUMAN	histone cluster 1, H2ac	48					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|lung(5)	12						TGGGGCAGGCGCGCCGGTGTACCTGGCGGCGGTGT	0.660													8	33	---	---	---	---					
ZNRD1-AS1	0	broad.mit.edu	37	6	29974883	29974883	+	RNA	DEL	C	C	-			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr6:29974883delC	ENST00000376797.3	-	0	1346				ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|HLA-J_ENST00000462773.1_RNA																							ATCACTTACTCCCCGCTCCAT	0.677													2	4	---	---	---	---					
PCF11	51585	broad.mit.edu	37	11	82877752	82877752	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr11:82877752delA	ENST00000298281.4	+	5	2265	c.1813delA	c.(1813-1815)aafs	p.K605fs		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	605					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						GGAAGAAAATAAAAGGTATGA	0.323													21	49	---	---	---	---					
DLG2	1740	broad.mit.edu	37	11	83676415	83676427	+	Frame_Shift_Del	DEL	TGGGTTTGCCAAC	TGGGTTTGCCAAC	-	rs144952538		TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr11:83676415_83676427delTGGGTTTGCCAAC	ENST00000398309.2	-	8	1296_1308	c.826_838delGTTGGCAAACCCA	c.(826-840)ctfs	p.VGKPT276fs	DLG2_ENST00000376106.3_5'UTR|DLG2_ENST00000537455.1_Frame_Shift_Del_p.VGKPT30fs|DLG2_ENST00000330014.6_Frame_Shift_Del_p.VGKPT215fs|DLG2_ENST00000532653.1_Frame_Shift_Del_p.VGKPT276fs|DLG2_ENST00000524982.1_Frame_Shift_Del_p.VGKPT276fs|DLG2_ENST00000531015.1_Frame_Shift_Del_p.VGKPT243fs|DLG2_ENST00000280241.8_Frame_Shift_Del_p.VGKPT315fs|DLG2_ENST00000418306.2_Frame_Shift_Del_p.VGKPT225fs|DLG2_ENST00000376104.2_Frame_Shift_Del_p.VGKPT381fs|DLG2_ENST00000543673.1_Frame_Shift_Del_p.VGKPT381fs|DLG2_ENST00000398301.2_Frame_Shift_Del_p.VGKPT315fs	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	276	PDZ 2.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TAAATGGTAGTGGGTTTGCCAACTTTTAAATAA	0.371													12	82	---	---	---	---					
DDX24	57062	broad.mit.edu	37	14	94527296	94527311	+	Frame_Shift_Del	DEL	CTTTAATTAATTCCCA	CTTTAATTAATTCCCA	-	rs77493762		TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr14:94527296_94527311delCTTTAATTAATTCCCA	ENST00000330836.5	-	4	1476_1491	c.1345_1360delTGGGAATTAATTAAAG	c.(1345-1362)aafs	p.WELIKE449fs	DDX24_ENST00000544005.1_Frame_Shift_Del_p.WELIKE199fs|DDX24_ENST00000555054.1_Frame_Shift_Del_p.WELIKE406fs	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	449	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		TAATGCTTTTCTTTAATTAATTCCCACAGCCGGCCT	0.454													7	51	---	---	---	---					
DNM1P47	0	broad.mit.edu	37	15	102306788	102306790	+	RNA	DEL	GTA	GTA	-			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr15:102306788_102306790delGTA	ENST00000561463.1	+	0	13180																											TTAGTCTGTTGTAGTGGTGAGCT	0.507													2	4	---	---	---	---					
KDM6B	23135	broad.mit.edu	37	17	7753140	7753146	+	Splice_Site	DEL	AATGCCA	AATGCCA	-			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr17:7753140_7753146delAATGCCA	ENST00000254846.5	+	12	3831_3837	c.3440_splice	c.e12-1	p.NAK1148_splice	KDM6B_ENST00000448097.2_Splice_Site_p.NAK1148_splice	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	1148					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						CTCCCGCAGGAATGCCAAGGTGAAAGG	0.565													27	88	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11085863	11085864	+	RNA	INS	-	-	C			TCGA-ZG-A8QY-01A-11D-A377-08	TCGA-ZG-A8QY-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	150b111d-aeb3-40fb-aa1f-cd991db33ece	951bf391-e24b-41f8-ba79-ba1ba44d09a8	g.chr21:11085863_11085864insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		catcaccaccaccaccatcacc	0.579													3	3	---	---	---	---