Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANKAR	150709	broad.mit.edu	37	2	190541595	190541595	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr2:190541595G>T	ENST00000520309.1	+	2	467	c.379G>T	c.(379-381)Gat>Tat	p.D127Y	ANKAR_ENST00000431575.2_Missense_Mutation_p.D56Y|ANKAR_ENST00000281412.6_5'UTR|ANKAR_ENST00000313581.4_Missense_Mutation_p.D127Y|ANKAR_ENST00000438402.2_Missense_Mutation_p.D127Y|ANKAR_ENST00000461516.1_Intron	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	127						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			AGCTAATTATGATCAGAGTTC	0.368000													50	29					1.67211e-32	1.96877e-32	1	1	0
ACY1	95	broad.mit.edu	37	3	52019884	52019884	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr3:52019884A>C	ENST00000458031.2	+	7	782	c.551A>C	c.(550-552)gAc>gCc	p.D184A	ACY1_ENST00000476351.1_Missense_Mutation_p.D59A|ABHD14A-ACY1_ENST00000463937.1_Missense_Mutation_p.D195A|ACY1_ENST00000468068.1_3'UTR|ACY1_ENST00000476854.1_Missense_Mutation_p.D94A|ACY1_ENST00000494103.1_Missense_Mutation_p.D94A|ACY1_ENST00000404366.2_Missense_Mutation_p.D94A			Q03154	ACY1_HUMAN	aminoacylase 1	94					cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	TGGAGTCACGACCCCTTTGAG	0.557000													5	15					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	845557	845557	+	Silent	SNP	C	C	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr4:845557C>A	ENST00000314167.4	-	25	3599	c.3489G>T	c.(3487-3489)ggG>ggT	p.G1163G	GAK_ENST00000511163.1_Silent_p.G1084G|GAK_ENST00000509566.1_5'UTR	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	1163					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		GTGCGCGGACCCCCCGCTCCT	0.597000													20	28					2.89027e-11	3.1491e-11	1	1	0
PTER	9317	broad.mit.edu	37	10	16553115	16553115	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr10:16553115C>T	ENST00000378000.1	+	6	1156	c.910C>T	c.(910-912)Cgg>Tgg	p.R304W	PTER_ENST00000423462.2_Missense_Mutation_p.R257W|PTER_ENST00000535784.2_Missense_Mutation_p.R304W|PTER_ENST00000298942.3_Missense_Mutation_p.R304W	NM_001001484.2|NM_001261838.1|NM_030664.4	NP_001001484.1|NP_001248767.1|NP_109589.2	Q96BW5	PTER_HUMAN	phosphotriesterase related	304					catabolic process		hydrolase activity, acting on ester bonds|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)	15						TACGAAAACCCGGCTGATGAA	0.423000													22	20					0	0	1	0	0
FAM66D	0	broad.mit.edu	37	8	11986193	11986193	+	RNA	SNP	T	T	C			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr8:11986193T>C	ENST00000434078.2	+	0	608					NR_027425.1																						AGACACTTGATTTGAGATCTC	0.493000													13	25					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158597474	158597474	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr1:158597474C>A	ENST00000368148.3	-	40	5785	c.5605G>T	c.(5605-5607)Gct>Tct	p.A1869S	SPTA1_ENST00000368147.3_Missense_Mutation_p.A1869S|SPTA1_ENST00000461624.1_5'UTR	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1869					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCATGGACAGCAAAGTCATTT	0.403000													33	92					2.66277e-13	2.99049e-13	1	1	0
RARB	5915	broad.mit.edu	37	3	25611284	25611284	+	Missense_Mutation	SNP	A	A	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr3:25611284A>T	ENST00000330688.4	+	4	905	c.484A>T	c.(484-486)Act>Tct	p.T162S	RARB_ENST00000458646.1_Missense_Mutation_p.T50S|RARB_ENST00000462272.1_3'UTR|RARB_ENST00000404969.1_Missense_Mutation_p.T169S|RARB_ENST00000437042.2_Missense_Mutation_p.T50S	NM_000965.3	NP_000956.2	P10826	RARB_HUMAN	retinoic acid receptor, beta	169	Hinge.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|kidney(1)|large_intestine(10)|lung(11)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	28					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	AAAGAAGGAGACTTCGAAGCA	0.502000													22	13					0	0	1	0	0
DIP2C	22982	broad.mit.edu	37	10	373036	373036	+	Silent	SNP	C	C	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr10:373036C>T	ENST00000280886.6	-	31	3921	c.3834G>A	c.(3832-3834)tcG>tcA	p.S1278S		NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	1278						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GCTTTGAGAACGACTGTGTGA	0.597000													3	29					0	0	1	0	0
PCDHB8	0	broad.mit.edu	37	5	140559154	140559154	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr5:140559154C>G	ENST00000239444.2	+	1	1784	c.1539C>G	c.(1537-1539)caC>caG	p.H513Q		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		513	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAACGGCCACCTGTTCGCCC	0.687000													24	82					0	0	1	0	0
SLITRK2	84631	broad.mit.edu	37	X	144904183	144904183	+	Silent	SNP	C	C	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chrX:144904183C>T	ENST00000370490.1	+	1	4495	c.240C>T	c.(238-240)aaC>aaT	p.N80N	SLITRK2_ENST00000447897.2_Silent_p.N80N|SLITRK2_ENST00000434188.2_Silent_p.N80N|SLITRK2_ENST00000428560.2_Silent_p.N80N|SLITRK2_ENST00000413937.2_Silent_p.N80N			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	80						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					TGTATCCAAACGAATTTGTCA	0.458000													7	68					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55433001	55433001	+	Missense_Mutation	SNP	G	G	A	rs137985207	byFrequency	TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr11:55433001G>A	ENST00000314259.3	+	1	388	c.359G>A	c.(358-360)cGc>cAc	p.R120H		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						GCCTATGACCGCTACGTGGCC	0.552000													14	57					0	0	1	0	0
KMO	8564	broad.mit.edu	37	1	241723980	241723980	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr1:241723980C>A	ENST00000366559.4	+	6	688	c.377C>A	c.(376-378)cCc>cAc	p.P126H	KMO_ENST00000366557.4_Missense_Mutation_p.P126H|KMO_ENST00000366558.3_Missense_Mutation_p.P126H|KMO_ENST00000484628.1_3'UTR	NM_003679.4	NP_003670.2	O15229	KMO_HUMAN	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	126					pyridine nucleotide biosynthetic process|response to salt stress	cytosol|integral to membrane|mitochondrial outer membrane	electron carrier activity|flavin adenine dinucleotide binding|kynurenine 3-monooxygenase activity|NAD(P)H oxidase activity			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Ovarian(103;0.103)|all_lung(81;0.23)		OV - Ovarian serous cystadenocarcinoma(106;0.0176)			GAGAAATACCCCAATGTGAAA	0.383000													14	39					8.60227e-14	9.81197e-14	1	1	0
DYRK4	8798	broad.mit.edu	37	12	4722817	4722817	+	Silent	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr12:4722817G>A	ENST00000540757.2	+	13	1621	c.1461G>A	c.(1459-1461)aaG>aaA	p.K487K	DYRK4_ENST00000010132.5_Silent_p.K487K|DYRK4_ENST00000545342.1_Silent_p.K124K|DYRK4_ENST00000543431.1_Silent_p.K486K	NM_003845.1	NP_003836.1	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	487						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27			Colorectal(7;0.103)			ACGCTCCCAAGAAGTCAGAGG	0.537000													13	38					0	0	1	0	0
RP11-65J21.3	0	broad.mit.edu	37	16	14397851	14397851	+	RNA	SNP	C	C	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr16:14397851C>T	ENST00000570945.1	+	0	310				MIR193B_ENST00000384907.1_RNA																							GTTTTGAGGGCGAGATGAGTT	0.572000													5	170					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11070441	11070441	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr3:11070441G>A	ENST00000287766.4	+	11	1520	c.1099G>A	c.(1099-1101)Gca>Aca	p.A367T	SLC6A1_ENST00000536032.1_Missense_Mutation_p.A189T	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	367					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	GGCGTTCCTGGCATACCCAGA	0.542000													3	34					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138617968	138617968	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr6:138617968A>G	ENST00000251691.4	+	21	3690	c.3524A>G	c.(3523-3525)gAc>gGc	p.D1175G		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	1175					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		TCCACTCAAGACCGAAAAAGC	0.522000													4	89					0	0	1	0	0
DDB1	1642	broad.mit.edu	37	11	61068375	61068375	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr11:61068375G>T	ENST00000301764.7	-	26	3642	c.3245C>A	c.(3244-3246)aCa>aAa	p.T1082K	DDB1_ENST00000451943.2_Missense_Mutation_p.T69K|DDB1_ENST00000450997.2_Missense_Mutation_p.T393K|DDB1_ENST00000538470.1_Missense_Mutation_p.T129K	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa	1082	Interaction with CDT1 and CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						GGCTGGTTCTGTCTTCCGCTC	0.517000								Nucleotide excision repair (NER)					34	18					4.11147e-13	4.54754e-13	1	1	0
TTN	7273	broad.mit.edu	37	2	179597209	179597209	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr2:179597209C>T	ENST00000589042.1	-	56	16803	c.16579G>A	c.(16579-16581)Gtc>Atc	p.V5527I	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.V5210I|TTN_ENST00000342992.6_Missense_Mutation_p.V4283I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5210	Ig-like 36.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCCAGCGACATTGCTGACT	0.393000													15	20					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576500	158576500	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr1:158576500C>A	ENST00000361284.1	+	1	272	c.272C>A	c.(271-273)gCt>gAt	p.A91D		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					GGGGACCAGGCTATCTCCTAT	0.537000													41	110					2.47872e-24	2.87217e-24	1	1	0
DDX50	79009	broad.mit.edu	37	10	70673848	70673848	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr10:70673848C>T	ENST00000373585.3	+	7	1084	c.977C>T	c.(976-978)tCt>tTt	p.S326F		NM_024045.1	NP_076950.1	Q9BQ39	DDX50_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 50	326	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	29						TTACTTTTTTCTGCAACTTGC	0.348000													6	26					0	0	1	0	0
ADC	113451	broad.mit.edu	37	1	33583687	33583687	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr1:33583687A>C	ENST00000294517.6	+	11	1801	c.1214A>C	c.(1213-1215)cAc>cCc	p.H405P	ADC_ENST00000373443.3_Missense_Mutation_p.H405P|ADC_ENST00000484656.1_3'UTR|ADC_ENST00000373441.1_Missense_Mutation_p.H425P|ADC_ENST00000398167.1_Missense_Mutation_p.H425P	NM_052998.2	NP_443724.1	Q96A70	ADC_HUMAN	arginine decarboxylase	405					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			NS(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	CAGGCCTGCCACATCACCTAT	0.592000													25	17					0	0	1	0	0
EDA	1896	broad.mit.edu	37	X	69253376	69253376	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chrX:69253376G>A	ENST00000374552.4	+	7	1164	c.922G>A	c.(922-924)Gaa>Aaa	p.E308K	EDA_ENST00000524573.1_Intron|EDA_ENST00000374553.2_Intron	NM_001399.4	NP_001390.1	Q92838	EDA_HUMAN	ectodysplasin A	308					cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|urinary_tract(1)	14						TAGTCAGGTAGAAGTGAGTAC	0.532000											OREG0019847	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	35					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49688434	49688434	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr3:49688434G>T	ENST00000296452.4	+	4	2022	c.1908G>T	c.(1906-1908)aaG>aaT	p.K636N		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	636					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CTAAAGTAAAGAGTGGGGTGA	0.602000													6	46					0.217242	0.220259	1	1	0
SNX19	399979	broad.mit.edu	37	11	130781573	130781573	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr11:130781573G>A	ENST00000265909.4	-	2	2337	c.1768C>T	c.(1768-1770)Cag>Tag	p.Q590*	SNX19_ENST00000530356.1_5'UTR|SNX19_ENST00000528555.1_5'UTR|SNX19_ENST00000533214.1_Nonsense_Mutation_p.Q590*|SNX19_ENST00000539184.1_Nonsense_Mutation_p.Q33*|SNX19_ENST00000533318.1_5'UTR	NM_014758.2	NP_055573.2	Q92543	SNX19_HUMAN	sorting nexin 19	590	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(8)|ovary(3)|prostate(1)|skin(6)|urinary_tract(1)	35	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		AGACGGGTCTGCAGATTCAAG	0.552000													29	30					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4832550	4832550	+	Silent	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr1:4832550G>A	ENST00000378191.4	+	4	1509	c.1128G>A	c.(1126-1128)acG>acA	p.T376T	AJAP1_ENST00000378190.3_Silent_p.T376T	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	376	Targeting signals.				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		TGCACTCGACGACGGGGGAGT	0.587000													4	24					0	0	1	0	0
TFPT	29844	broad.mit.edu	37	19	54610362	54610362	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr19:54610362C>T	ENST00000391759.1	-	6	1162	c.757G>A	c.(757-759)Gac>Aac	p.D253N	NDUFA3_ENST00000391764.3_Intron|TFPT_ENST00000391758.1_Missense_Mutation_p.D244N|NDUFA3_ENST00000485876.1_3'UTR|TFPT_ENST00000391757.1_3'UTR	NM_013342.3	NP_037474.1	P0C1Z6	TFPT_HUMAN	TCF3 (E2A) fusion partner (in childhood Leukemia)	253					apoptosis|DNA recombination|DNA repair|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex	DNA binding|protein binding			large_intestine(2)|lung(2)	4	all_cancers(19;0.004)|all_epithelial(19;0.00195)|all_lung(19;0.0193)|Lung NSC(19;0.0358)|Breast(117;0.137)|Ovarian(34;0.19)					ATGCGTCAGTCAGAGGCTGGG	0.577000			T	TCF3	pre-B ALL								45	28					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169510354	169510354	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr1:169510354A>G	ENST00000367796.3	-	13	4190	c.3989T>C	c.(3988-3990)cTc>cCc	p.L1330P	F5_ENST00000367797.3_Missense_Mutation_p.L1325P			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1325	35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TGTATGGCTGAGGTCTGGAGA	0.512000													5	248					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7724954	7724954	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr1:7724954G>A	ENST00000303635.7	+	9	2554	c.2347G>A	c.(2347-2349)Gtg>Atg	p.V783M	CAMTA1_ENST00000439411.2_Missense_Mutation_p.V783M	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	783					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CTTCATCTCCGTGGAGGGGGG	0.637000			T	WWTR1	epitheliod hemangioendothelioma								17	263					0	0	1	0	0
LPO	0	broad.mit.edu	37	17	56329723	56329723	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr17:56329723C>A	ENST00000262290.4	+	8	1277	c.961C>A	c.(961-963)Cgc>Agc	p.R321S	LPO_ENST00000582328.1_Missense_Mutation_p.R238S|LPO_ENST00000421678.2_Missense_Mutation_p.R238S|LPO_ENST00000543544.1_Missense_Mutation_p.R262S	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	321					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity	p.R321C(1)		breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						CAGCCGCCTCCGCAACCTCAG	0.617000													5	23					1	1	1	1	0
IGKV1D-43	0	broad.mit.edu	37	2	90249360	90249360	+	RNA	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr2:90249360G>A	ENST00000468879.1	+	0	497																											TGAAGATTTTGCAACTTATTA	0.512000													4	128					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141719106	141719106	+	Silent	SNP	C	C	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr7:141719106C>T	ENST00000475668.2	+	4	489	c.435C>T	c.(433-435)gtC>gtT	p.V145V	MGAM_ENST00000549489.2_Silent_p.V145V			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	145					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GCAACCTTGTCAACACAAATG	0.542000													8	26					0	0	1	0	0
RPS4Y2	140032	broad.mit.edu	37	Y	22930773	22930773	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chrY:22930773G>A	ENST00000288666.5	+	5	443	c.443G>A	c.(442-444)cGc>cAc	p.R148H		NM_001039567.2	NP_001034656.1	Q8TD47	RS4Y2_HUMAN	ribosomal protein S4, Y-linked 2	148					translation	ribosome	rRNA binding|structural constituent of ribosome			lung(2)	2						CGAACCATTCGCTACCCAGAT	0.423000													54	7					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134664756	134664756	+	Silent	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr10:134664756G>A	ENST00000368586.5	-	40	5728	c.5628C>T	c.(5626-5628)ggC>ggT	p.G1876G	TTC40_ENST00000263170.5_Silent_p.G37G	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	37										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						TTTCCACGAGGCCGAGCTTGA	0.612000													8	29					0	0	1	0	0
KRT18P55	0	broad.mit.edu	37	17	26604099	26604099	+	RNA	SNP	C	C	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr17:26604099C>T	ENST00000577198.1	-	0	862					NR_028334.1																						GCCAGGTGGTCGTTGAGGCTT	0.607000													8	60					0	0	1	0	0
HSD17B2	3294	broad.mit.edu	37	16	82132014	82132014	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr16:82132014G>T	ENST00000199936.4	+	5	1330	c.1137G>T	c.(1135-1137)atG>atT	p.M379I	RP11-510J16.5_ENST00000567021.1_RNA	NM_002153.2	NP_002144.1	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	379					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10					NADH(DB00157)	CTCTAAGAATGCCTAACTACA	0.433000													15	80					5.03518e-11	5.40542e-11	1	1	0
CCBL1	883	broad.mit.edu	37	9	131597626	131597626	+	Silent	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr9:131597626G>A	ENST00000436267.2	-	13	1529	c.1380C>T	c.(1378-1380)ttC>ttT	p.F460F	CCBL1_ENST00000302586.3_Silent_p.F366F|CCBL1_ENST00000483599.1_5'UTR|CCBL1_ENST00000320665.6_Silent_p.F316F			Q16773	KAT1_HUMAN	cysteine conjugate-beta lyase, cytoplasmic	366					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)	18					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	TCCACTTGACGAAGCGTCTGT	0.597000													24	175					0	0	1	0	0
LRRC37A11P	0	broad.mit.edu	37	17	37188096	37188096	+	RNA	SNP	T	T	C			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr17:37188096T>C	ENST00000425901.2	+	0	1938					NR_033753.2																						GGGCTTACCATCACTCCAGAA	0.517000													5	90					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49427951	49427951	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr12:49427951G>A	ENST00000301067.7	-	38	10638	c.10639C>T	c.(10639-10641)Cgc>Tgc	p.R3547C		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TTGGCAGTGCGCTGCTTGGCA	0.542000													6	64					0	0	1	0	0
PLBD2	196463	broad.mit.edu	37	12	113825600	113825600	+	Silent	SNP	C	C	G			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr12:113825600C>G	ENST00000280800.3	+	11	1522	c.1491C>G	c.(1489-1491)ccC>ccG	p.P497P	PLBD2_ENST00000545182.2_Silent_p.P465P	NM_173542.3	NP_775813.2	Q8NHP8	PLBL2_HUMAN	phospholipase B domain containing 2	497					lipid catabolic process	lysosomal lumen	hydrolase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						CCTGCAACCCCCAGCCCAATG	0.602000													287	172					0	0	1	0	0
CUL5	8065	broad.mit.edu	37	11	107969215	107969215	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr11:107969215G>C	ENST00000393094.2	+	18	2723	c.2107G>C	c.(2107-2109)Gag>Cag	p.E703Q		NM_003478.3	NP_003469.2	Q93034	CUL5_HUMAN	cullin 5	703					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		GAGAGAAGAAGAGAATGAAGG	0.318000													7	58					0	0	1	0	0
STOX2	56977	broad.mit.edu	37	4	184930876	184930876	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr4:184930876G>A	ENST00000308497.4	+	3	2320	c.885G>A	c.(883-885)tgG>tgA	p.W295*	STOX2_ENST00000438269.1_Nonsense_Mutation_p.W295*	NM_020225.1	NP_064610.1	Q9P2F5	STOX2_HUMAN	storkhead box 2	295					embryo development|maternal placenta development					breast(1)|endometrium(7)|lung(6)	14		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		CTGAAGAGTGGCCCCTGCGAG	0.473000													4	6					0	0	1	0	0
METTL13	51603	broad.mit.edu	37	1	171761359	171761359	+	Silent	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr1:171761359G>A	ENST00000361735.3	+	6	1943	c.1677G>A	c.(1675-1677)ttG>ttA	p.L559L	METTL13_ENST00000362019.3_Silent_p.L473L|METTL13_ENST00000367737.5_Silent_p.L403L|METTL13_ENST00000458517.1_Silent_p.L558L|METTL13_ENST00000466643.1_3'UTR	NM_015935.4	NP_057019.3	Q8N6R0	MTL13_HUMAN	methyltransferase like 13	559							methyltransferase activity|protein binding			breast(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(8)|lung(17)|stomach(3)	41						TCGCCAGCTTGGCAGGAGGAG	0.537000													30	53					0	0	1	0	0
DYNC1I1	1780	broad.mit.edu	37	7	95616435	95616435	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr7:95616435C>G	ENST00000324972.6	+	9	1055	c.862C>G	c.(862-864)Cga>Gga	p.R288G	DYNC1I1_ENST00000447467.2_Missense_Mutation_p.R271G|DYNC1I1_ENST00000537881.1_Missense_Mutation_p.R251G|DYNC1I1_ENST00000437599.1_Missense_Mutation_p.R268G|DYNC1I1_ENST00000457059.1_Missense_Mutation_p.R271G|DYNC1I1_ENST00000359388.4_Missense_Mutation_p.R251G	NM_004411.4	NP_004402.1	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	288					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(27)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	54	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			GTCCAAGCATCGAGTGGTCAC	0.428000													8	231					0	0	1	0	0
SYT9	143425	broad.mit.edu	37	11	7334874	7334874	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr11:7334874C>T	ENST00000318881.6	+	3	983	c.746C>T	c.(745-747)gCc>gTc	p.A249V	SYT9_ENST00000396716.2_Missense_Mutation_p.A217V	NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	249	C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		AATTTGCCCGCCAAGGACTTT	0.408000													18	91					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881480	228881480	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr2:228881480C>G	ENST00000392056.3	-	7	4136	c.4090G>C	c.(4090-4092)Gtt>Ctt	p.V1364L	SPHKAP_ENST00000344657.5_Missense_Mutation_p.V1364L	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1364						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GACTCCTGAACAAGCAGAGTT	0.507000													44	26					0	0	1	0	0
MELK	9833	broad.mit.edu	37	9	36643018	36643018	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr9:36643018G>A	ENST00000543751.1	+	10	908	c.763G>A	c.(763-765)Gta>Ata	p.V255I	MELK_ENST00000545008.1_Missense_Mutation_p.V216I|MELK_ENST00000538311.1_Missense_Mutation_p.V93I|MELK_ENST00000536329.1_Missense_Mutation_p.V216I|MELK_ENST00000298048.2_Missense_Mutation_p.V287I|MELK_ENST00000536860.1_Missense_Mutation_p.V239I|MELK_ENST00000536987.1_Missense_Mutation_p.V156I|MELK_ENST00000541717.1_Missense_Mutation_p.V287I	NM_001256689.1	NP_001243618.1	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	287	Protein kinase.					cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)			TGATGATTGCGTAACAGAACT	0.338000													16	52					0	0	1	0	0
SLC2A12	154091	broad.mit.edu	37	6	134350120	134350120	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr6:134350120T>C	ENST00000275230.5	-	2	998	c.843A>G	c.(841-843)atA>atG	p.I281M		NM_145176.2	NP_660159.1	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 12	281						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	17	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		GTGTTAGTCCTATCATTATTC	0.378000													21	42					0	0	1	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227203873	227203873	+	Silent	SNP	T	T	G			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr1:227203873T>G	ENST00000366769.3	-	33	5951	c.4660A>C	c.(4660-4662)Aga>Cga	p.R1554R	CDC42BPA_ENST00000366767.3_Silent_p.R1473R|CDC42BPA_ENST00000366765.3_Silent_p.R1567R|CDC42BPA_ENST00000535525.1_Silent_p.R1534R|CDC42BPA_ENST00000366766.2_Silent_p.R1589R|CDC42BPA_ENST00000366764.2_Silent_p.R1526R|CDC42BPA_ENST00000334218.5_Silent_p.R1554R	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	1567					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				AATTTATTTCTCATTTCTGGA	0.343000													6	87					0	0	1	0	0
GOLGA6L5	0	broad.mit.edu	37	15	85053219	85053219	+	RNA	SNP	C	C	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr15:85053219C>T	ENST00000414190.2	-	0	233					NR_003246.2																						TGCAGCCTCTCCTGCTCCTCC	0.522000													3	1					0	0	1	0	0
E2F1	1869	broad.mit.edu	37	20	32265317	32265317	+	Missense_Mutation	SNP	C	C	T	rs3213172		TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr20:32265317C>T	ENST00000343380.5	-	5	894	c.755G>A	c.(754-756)cGt>cAt	p.R252H		NM_005225.2	NP_005216.1	Q01094	E2F1_HUMAN	E2F transcription factor 1	252	Dimerization (Potential).|Required for interaction with TRIM28.		R -> H (in dbSNP:rs3213172).		apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding			NS(2)|breast(1)|endometrium(3)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	16						TGCAATGCTACGAAGGTCCTG	0.562000													4	37					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196963263	196963263	+	Nonsense_Mutation	SNP	A	A	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr1:196963263A>T	ENST00000367414.5	+	4	612	c.556A>T	c.(556-558)Aaa>Taa	p.K186*	CFHR5_ENST00000256785.4_Nonsense_Mutation_p.K162*	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	162	Sushi 3.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						TCAGCCAAAAAAAGAAAGCTA	0.338000													61	47					0	0	1	0	0
OR9I1	219954	broad.mit.edu	37	11	57886677	57886677	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr11:57886677C>A	ENST00000302610.1	-	1	239	c.240G>T	c.(238-240)caG>caT	p.Q80H	OR9Q1_ENST00000335397.3_Intron	NM_001005211.1	NP_001005211.1	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I, member 1	80					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|liver(1)|lung(15)|pancreas(1)|skin(1)|urinary_tract(1)	23		Breast(21;0.0589)				TGGCTAGGATCTGAGGGGTGA	0.507000													8	24					1.76689e-08	1.81667e-08	1	1	0
MYH2	4620	broad.mit.edu	37	17	10447217	10447217	+	Splice_Site	SNP	A	A	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr17:10447217A>T	ENST00000245503.5	-	7	1033		c.e7+1		MYH2_ENST00000532183.1_Splice_Site|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Splice_Site	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult						muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.?(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						AATCAGACTCACCTGTATTTT	0.478000													4	47					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53621471	53621471	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chrX:53621471T>C	ENST00000342160.3	-	30	3948	c.3491A>G	c.(3490-3492)aAt>aGt	p.N1164S	HUWE1_ENST00000262854.6_Missense_Mutation_p.N1164S|HUWE1_ENST00000218328.8_Missense_Mutation_p.N1164S			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1164					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						AAAAAGAGCATTGTGGCCTCC	0.458000													4	10					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21268268	21268268	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr1:21268268G>T	ENST00000602326.1	-	12	1812	c.1229C>A	c.(1228-1230)gCt>gAt	p.A410D	EIF4G3_ENST00000400422.1_Missense_Mutation_p.A404D|EIF4G3_ENST00000374927.4_Missense_Mutation_p.A404D|EIF4G3_ENST00000374935.3_Intron|EIF4G3_ENST00000374937.3_Missense_Mutation_p.A410D|EIF4G3_ENST00000356916.3_Missense_Mutation_p.A415D|EIF4G3_ENST00000264211.8_Missense_Mutation_p.A404D|EIF4G3_ENST00000536266.1_Missense_Mutation_p.A8D	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	404					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GGTGATGGGAGCTGGGATACA	0.478000													15	59					1.5739e-10	1.66514e-10	1	1	0
OR51E2	81285	broad.mit.edu	37	11	4703866	4703866	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr11:4703866C>T	ENST00000396950.3	-	2	315	c.76G>A	c.(76-78)Gtt>Att	p.V26I		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		GGGAAGCCAACCCAGAAATGG	0.507000													5	36					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	102987372	102987372	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr11:102987372A>G	ENST00000375735.2	+	5	839	c.695A>G	c.(694-696)gAt>gGt	p.D232G	DYNC2H1_ENST00000398093.3_Missense_Mutation_p.D232G|DYNC2H1_ENST00000334267.7_Missense_Mutation_p.D232G	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	232	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GATGTTGTAGATGATGTGTGG	0.338000													16	77					0	0	1	0	0
VANGL2	57216	broad.mit.edu	37	1	160388965	160388965	+	Silent	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr1:160388965G>A	ENST00000368061.2	+	4	840	c.366G>A	c.(364-366)acG>acA	p.T122T		NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	122					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTTTCCTCACGCCTCTGGCCT	0.667000													18	38					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32632931	32632931	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr9:32632931G>C	ENST00000242310.4	-	1	2736	c.2647C>G	c.(2647-2649)Ctt>Gtt	p.L883V		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	883					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCAGACTTAAGCACCCACCAG	0.463000													8	172					0	0	1	0	0
DGKZ	8525	broad.mit.edu	37	11	46397443	46397443	+	Silent	SNP	C	C	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr11:46397443C>T	ENST00000454345.1	+	22	2642	c.2517C>T	c.(2515-2517)cgC>cgT	p.R839R	DGKZ_ENST00000318201.8_Silent_p.R628R|DGKZ_ENST00000532868.2_Silent_p.R655R|DGKZ_ENST00000395574.3_Silent_p.R617R|DGKZ_ENST00000456247.2_Silent_p.R650R|DGKZ_ENST00000528615.1_Silent_p.R429R|DGKZ_ENST00000527911.1_Silent_p.R651R|DGKZ_ENST00000421244.2_Silent_p.R651R|DGKZ_ENST00000543978.1_Intron|DGKZ_ENST00000343674.6_Silent_p.R667R	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	839					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		AGGTGAGTCGCGTCAGCATGC	0.692000													3	3					0	0	1	0	0
ALAS1	211	broad.mit.edu	37	3	52246385	52246385	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr3:52246385C>T	ENST00000394965.2	+	11	2071	c.1711C>T	c.(1711-1713)Cgg>Tgg	p.R571W	ALAS1_ENST00000484952.1_Missense_Mutation_p.R571W|ALAS1_ENST00000469224.1_Missense_Mutation_p.R571W|ALAS1_ENST00000310271.2_Missense_Mutation_p.R571W	NM_000688.5	NP_000679.1	P13196	HEM1_HUMAN	aminolevulinate, delta-, synthase 1	571					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			endometrium(3)|kidney(3)|large_intestine(7)|liver(2)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	AGAGCTCCTACGGATTGCCCC	0.517000													46	156					0	0	1	0	0
ARMC2	84071	broad.mit.edu	37	6	109215691	109215691	+	Silent	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr6:109215691G>A	ENST00000392644.4	+	6	861	c.693G>A	c.(691-693)gcG>gcA	p.A231A	ARMC2_ENST00000368972.3_Silent_p.A66A	NM_032131.4	NP_115507.4	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	231							binding			endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|skin(1)	24		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		AGAGACATGCGAGGGCCTCAT	0.483000													21	4					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228437698	228437698	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr1:228437698G>A	ENST00000570156.2	+	15	4416	c.4342G>A	c.(4342-4344)Gca>Aca	p.A1448T	OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000422127.1_Missense_Mutation_p.A1356T|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000284548.11_Missense_Mutation_p.A1356T	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	426	Ig-like 15.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGAGCAGCTGGCACACAGGAA	0.627000													24	92					0	0	1	0	0
PIK3R1	5295	broad.mit.edu	37	5	67591318	67591319	+	Splice_Site	INS	-	-	A			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr5:67591318_67591319insA	ENST00000521381.1	+	14	2430		c.e14+2		PIK3R1_ENST00000336483.5_Splice_Site|PIK3R1_ENST00000521657.1_Splice_Site|PIK3R1_ENST00000523872.1_Splice_Site|PIK3R1_ENST00000274335.5_Splice_Site|PIK3R1_ENST00000320694.8_Splice_Site|PIK3R1_ENST00000396611.1_Splice_Site	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)						epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(2)|p.Y580fs*1(1)|p.0?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CACTGAAGAGTAAGTAGTTACT	0.356			"""Mis, F, O"""		"""gliobastoma, ovarian, colorectal"""					TCGA GBM(4;<1E-08)			18	27	---	---	---	---					
APOBEC2	10930	broad.mit.edu	37	6	41029171	41029172	+	Frame_Shift_Ins	INS	-	-	G			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr6:41029171_41029172insG	ENST00000244669.2	+	2	280_281	c.236_237insG	c.(235-237)aggfs	p.R79fs		NM_006789.3	NP_006780.1	Q9Y235	ABEC2_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2	79					DNA demethylation|mRNA processing		cytidine deaminase activity|RNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)|skin(1)	10	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCACAGGGCAAGGGGGGCCAAG	0.559													19	40	---	---	---	---					
MTHFD1L	25902	broad.mit.edu	37	6	151209057	151209057	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr6:151209057delC	ENST00000367321.3	+	7	994	c.720delC	c.(718-720)ttfs	p.F240fs	MTHFD1L_ENST00000367307.4_Frame_Shift_Del_p.F240fs	NM_001242767.1|NM_001242768.1|NM_015440.4	NP_001229696.1|NP_001229697.1|NP_056255.2	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	240	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	29		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		AATGCCTGTTCCAGAGAAAAG	0.428													31	77	---	---	---	---					
CDK2AP2	10263	broad.mit.edu	37	11	67275498	67275498	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr11:67275498delG	ENST00000301488.3	-	1	604	c.56delC	c.(55-57)ctfs	p.P19fs	CDK2AP2_ENST00000531506.1_Frame_Shift_Del_p.P19fs	NM_005851.3	NP_005842.1	O75956	CDKA2_HUMAN	cyclin-dependent kinase 2 associated protein 2	19										lung(1)	1						GCCCGGCCCAGGGGTGCTGGA	0.711													2	4	---	---	---	---					
UBL7	84993	broad.mit.edu	37	15	74744688	74744689	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr15:74744688_74744689delCT	ENST00000567435.1	-	4	798_799	c.335_336delAG	c.(334-336)gfs	p.E112fs	UBL7_ENST00000565335.1_Frame_Shift_Del_p.E112fs|UBL7_ENST00000361351.4_Frame_Shift_Del_p.E112fs|UBL7_ENST00000395081.2_Frame_Shift_Del_p.E112fs|UBL7_ENST00000564488.1_Frame_Shift_Del_p.E112fs			Q96S82	UBL7_HUMAN	ubiquitin-like 7 (bone marrow stromal cell-derived)	112							protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9						ACACCCGGAACTCTCTCATGGC	0.579													2	4	---	---	---	---					
TFAP4	7023	broad.mit.edu	37	16	4310592	4310593	+	Frame_Shift_Ins	INS	-	-	G			TCGA-ZG-A9L5-01A-12D-A41K-08	TCGA-ZG-A9L5-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd23f776-bd81-4c83-b0a2-6657ac9fd76d	0c8cd31c-0194-4b85-bb50-ba9f14c78b19	g.chr16:4310592_4310593insG	ENST00000204517.6	-	5	857_858	c.529_530insC	c.(529-531)ctcfs	p.L177fs		NM_003223.2	NP_003214.1	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer binding protein 4)	177	Leucine-zipper 2.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|endometrium(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						CTCCAGCGAGCGCACCTGGAGG	0.624													6	9	---	---	---	---