Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NR2C1	7181	broad.mit.edu	37	12	95452139	95452139	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr12:95452139C>T	ENST00000333003.5	-	5	821	c.491G>A	c.(490-492)cGc>cAc	p.R164H	NR2C1_ENST00000545833.1_5'UTR|NR2C1_ENST00000393101.3_Missense_Mutation_p.R164H|NR2C1_ENST00000330677.7_Missense_Mutation_p.R164H	NM_003297.3	NP_003288.2	P13056	NR2C1_HUMAN	nuclear receptor subfamily 2, group C, member 1	164	Required for interaction with KAT2B (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)	13						GTATTGACAGCGGTTTCGGTG	0.348000													5	61					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115142031	115142031	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr1:115142031T>C	ENST00000393274.1	-	16	2772	c.2147A>G	c.(2146-2148)tAt>tGt	p.Y716C	DENND2C_ENST00000481894.1_5'UTR|DENND2C_ENST00000393277.1_Intron|DENND2C_ENST00000393276.3_Missense_Mutation_p.Y659C	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	716	DENN.									NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGTGAACGGATACAGTGTAGC	0.458000													8	33					0	0	1	0	0
TM9SF4	9777	broad.mit.edu	37	20	30732918	30732918	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr20:30732918C>T	ENST00000217315.5	+	7	966	c.626C>T	c.(625-627)tCg>tTg	p.S209L	TM9SF4_ENST00000398022.2_Missense_Mutation_p.S226L			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	226						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GAGAAGAGTTCGTGCACTCTG	0.562000													8	30					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126336650	126336650	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr4:126336650G>A	ENST00000394329.3	+	5	6545	c.6532G>A	c.(6532-6534)Gca>Aca	p.A2178T	FAT4_ENST00000335110.5_Missense_Mutation_p.A476T	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2178	Cadherin 21.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.A2178S(2)|p.A2178P(2)		NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ACAAGTGTTCGCAGCAGATGG	0.398000													13	81					0	0	1	0	0
NGEF	25791	broad.mit.edu	37	2	233759485	233759485	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr2:233759485C>T	ENST00000264051.3	-	6	1248	c.970G>A	c.(970-972)Gtg>Atg	p.V324M	NGEF_ENST00000539537.1_Missense_Mutation_p.V47M|NGEF_ENST00000373552.4_Missense_Mutation_p.V232M|NGEF_ENST00000409079.1_Missense_Mutation_p.V232M	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	324	DH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		ACAGCCAGCACGTCCAGGACG	0.602000													7	37					0	0	1	0	0
SLC6A14	11254	broad.mit.edu	37	X	115576109	115576109	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chrX:115576109G>A	ENST00000371900.4	+	6	768	c.680G>A	c.(679-681)aGt>aAt	p.S227N		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	227					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	CAACGGTCAAGTGGAATGAAT	0.368000													10	19					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370518	35370518	+	Missense_Mutation	SNP	G	G	A	rs144823481		TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr1:35370518G>A	ENST00000373347.1	-	3	735	c.467C>T	c.(466-468)aCg>aTg	p.T156M	DLGAP3_ENST00000235180.4_Missense_Mutation_p.T156M			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	156					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				GGCAGTGCCCGTCCCTGGCGC	0.622000													4	20					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216243939	216243939	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr2:216243939G>A	ENST00000354785.4	-	34	5905	c.5536C>T	c.(5536-5538)Cgg>Tgg	p.R1846W	FN1_ENST00000359671.1_Missense_Mutation_p.R1755W|FN1_ENST00000357867.4_Missense_Mutation_p.R1665W|FN1_ENST00000490833.1_5'UTR|FN1_ENST00000336916.4_Missense_Mutation_p.R1755W|FN1_ENST00000356005.4_Missense_Mutation_p.R1665W|FN1_ENST00000323926.6_Missense_Mutation_p.R1846W|FN1_ENST00000357009.2_Missense_Mutation_p.R1755W|FN1_ENST00000346544.3_Missense_Mutation_p.R1755W|FN1_ENST00000345488.5_Missense_Mutation_p.R1755W|FN1_ENST00000421182.1_Missense_Mutation_p.R1665W|FN1_ENST00000443816.1_Missense_Mutation_p.R1665W|FN1_ENST00000446046.1_Missense_Mutation_p.R1755W|FN1_ENST00000432072.2_Missense_Mutation_p.R1756W			P02751	FINC_HUMAN	fibronectin 1	1847	Binds to FBLN1.|Fibronectin type-III 14.|Heparin-binding 2.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGGTCACCCGCACTCGATAT	0.527000													7	47					0	0	1	0	0
MFN2	9927	broad.mit.edu	37	1	12058885	12058885	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr1:12058885G>T	ENST00000235329.5	+	7	980	c.658G>T	c.(658-660)Gct>Tct	p.A220S	MFN2_ENST00000444836.1_Missense_Mutation_p.A220S	NM_014874.3	NP_055689.1	O95140	MFN2_HUMAN	mitofusin 2	220					blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	20	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TTGTCTGGATGCTGATGTGTT	0.552000													23	165					5.26018e-13	5.77588e-13	1	1	0
PNLIP	5406	broad.mit.edu	37	10	118306869	118306869	+	Missense_Mutation	SNP	C	C	T	rs140844816		TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr10:118306869C>T	ENST00000369221.2	+	3	138	c.110C>T	c.(109-111)aCg>aTg	p.T37M	PNLIP_ENST00000470562.1_3'UTR	NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	37					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TCAGGAATTACGGAAAGACCC	0.428000													14	53					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000403642.1_Silent_p.S281S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	48					0	0	1	0	0
PHF16	0	broad.mit.edu	37	X	46913789	46913789	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chrX:46913789G>A	ENST00000218343.4	+	9	1500	c.1202G>A	c.(1201-1203)cGg>cAg	p.R401Q	PHF16_ENST00000397189.1_Missense_Mutation_p.R401Q	NM_014735.3	NP_055550.1	Q92613	JADE3_HUMAN		401					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(2)	33						CAGAAGCTTCGGGAGCTGGAG	0.542000													9	17					0	0	1	0	0
HIP1R	9026	broad.mit.edu	37	12	123345916	123345916	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr12:123345916G>A	ENST00000253083.4	+	31	3139	c.3014G>A	c.(3013-3015)cGg>cAg	p.R1005Q		NM_003959.1	NP_003950.1	O75146	HIP1R_HUMAN	huntingtin interacting protein 1 related	1005	I/LWEQ.				receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			breast(1)|endometrium(5)|kidney(6)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	26	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		GGGGAGTTGCGGAAGCAACAC	0.657000													4	31					0	0	1	0	0
PCDHAC1	0	broad.mit.edu	37	5	140308818	140308818	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr5:140308818C>T	ENST00000253807.2	+	1	2341	c.2341C>T	c.(2341-2343)Cga>Tga	p.R781*	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHAC1_ENST00000409700.3_Nonsense_Mutation_p.R781*|PCDHA13_ENST00000289272.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCCGACCTGCGAAATCTTGC	0.468000													16	60					0	0	1	0	0
POM121C	100101267	broad.mit.edu	37	7	75066917	75066917	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr7:75066917T>C	ENST00000453279.2	-	7	1220	c.356A>G	c.(355-357)cAc>cGc	p.H119R	POM121C_ENST00000257665.5_Missense_Mutation_p.H361R	NM_001099415.1	NP_001092885.1	A8CG34	P121C_HUMAN	POM121 transmembrane nucleoporin C	361	Pore side (Potential).|Required for targeting to the nucleus and nuclear pore complex.				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14						CTTATTCAAGTGGTCATCTGA	0.473000													21	58					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13414687	13414687	+	Silent	SNP	G	G	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr19:13414687G>A	ENST00000360228.5	-	16	1997	c.1998C>T	c.(1996-1998)ggC>ggT	p.G666G	CACNA1A_ENST00000573710.2_Silent_p.G667G	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	667			T -> M (in FHM1 and EA2; dbSNP:rs121908212).		cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TCCAGTCTTCGCCCGTCAGGA	0.592000													20	92					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121383372	121383372	+	Silent	SNP	T	T	C			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr3:121383372T>C	ENST00000393667.3	-	22	9875	c.9765A>G	c.(9763-9765)ctA>ctG	p.L3255L	GOLGB1_ENST00000340645.5_Silent_p.L3245L	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	3245					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		CATGAATCATTAGAAAGTAGA	0.478000													11	33					0	0	1	0	0
MST1	4485	broad.mit.edu	37	3	49725284	49725284	+	Silent	SNP	C	C	T			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr3:49725284C>T	ENST00000449682.2	-	2	502	c.141G>A	c.(139-141)gaG>gaA	p.E47E	MST1_ENST00000545762.1_Silent_p.E33E|MST1_ENST00000494828.2_Intron|MST1_ENST00000383728.3_Intron	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	33	PAN.				proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GGTGCTGTAGCTCTGTGCCCC	0.597000													5	14					0	0	1	0	0
SHROOM2	357	broad.mit.edu	37	X	9900641	9900641	+	Silent	SNP	G	G	T			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chrX:9900641G>T	ENST00000380913.3	+	6	3408	c.3318G>T	c.(3316-3318)gtG>gtT	p.V1106V	SHROOM2_ENST00000418909.2_5'UTR|SHROOM2_ENST00000493668.1_3'UTR	NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	1106					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				ATGTGTATGTGGCCCGCCTGT	0.672000													7	12					0.00198382	0.00198382	1	1	0
KRT4	3851	broad.mit.edu	37	12	53202551	53202551	+	Silent	SNP	G	G	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr12:53202551G>A	ENST00000551956.1	-	5	1410	c.918C>T	c.(916-918)agC>agT	p.S306S	KRT4_ENST00000458244.2_Silent_p.S286S|KRT4_ENST00000293774.4_Silent_p.S380S			B4DRS2	B4DRS2_HUMAN	keratin 4	306						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						CGGCAATAATGCTGTCCAGGT	0.577000													18	50					0	0	1	0	0
MYCT1	80177	broad.mit.edu	37	6	153043116	153043116	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr6:153043116C>T	ENST00000367245.5	+	2	444	c.436C>T	c.(436-438)Cga>Tga	p.R146*	MYCT1_ENST00000529453.1_Intron	NM_025107.2	NP_079383.2	Q8N699	MYCT1_HUMAN	myc target 1	146						nucleus				NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	20		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		CACCTTCCAGCGACAAGCTTC	0.498000													10	62					0	0	1	0	0
HIST1H4E	8367	broad.mit.edu	37	6	26205164	26205164	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr6:26205164C>T	ENST00000360441.4	+	1	307	c.292C>T	c.(292-294)Ctt>Ttt	p.L98F		NM_003545.3	NP_003536.1	P62805	H4_HUMAN	histone cluster 1, H4e	98					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(2)	18		all_hematologic(11;0.196)				GGGACGCACTCTTTACGGCTT	0.532000													12	28					0	0	1	0	0
LIG4	3981	broad.mit.edu	37	13	108862028	108862028	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr13:108862028T>C	ENST00000356922.4	-	2	1861	c.1589A>G	c.(1588-1590)cAt>cGt	p.H530R	LIG4_ENST00000405925.1_Missense_Mutation_p.H530R|LIG4_ENST00000442234.1_Missense_Mutation_p.H530R	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	530					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					AGCTTTTCTATGAAAAGGCTT	0.418000								Non-homologous end-joining					19	66					0	0	1	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39261693	39261693	+	Missense_Mutation	SNP	A	A	T	rs113059833	by1000genomes	TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr17:39261693A>T	ENST00000391415.1	+	1	110	c.53A>T	c.(52-54)gAc>gTc	p.D18V		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	18						keratin filament		p.D18V(1)		central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						TGCGGCCAAGACCTCTGTCAG	0.627000													5	30					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887612	12887612	+	Missense_Mutation	SNP	T	T	C	rs60558629		TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr1:12887612T>C	ENST00000535591.1	-	3	440	c.245A>G	c.(244-246)cAt>cGt	p.H82R		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	82								p.H82R(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GAAGCACCCATGGGCCATAGC	0.488000													5	233					0	0	1	0	0
KRT4	3851	broad.mit.edu	37	12	53202552	53202552	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr12:53202552C>A	ENST00000551956.1	-	5	1409	c.917G>T	c.(916-918)aGc>aTc	p.S306I	KRT4_ENST00000458244.2_Missense_Mutation_p.S286I|KRT4_ENST00000293774.4_Missense_Mutation_p.S380I			B4DRS2	B4DRS2_HUMAN	keratin 4	306						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						GGCAATAATGCTGTCCAGGTC	0.582000													18	50					9.7654e-05	0.000101271	1	1	0
FRG1	2483	broad.mit.edu	37	4	190874231	190874231	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr4:190874231G>A	ENST00000226798.4	+	4	490	c.268G>A	c.(268-270)Ggc>Agc	p.G90S	FRG1_ENST00000514482.1_3'UTR	NM_004477.2	NP_004468.1	Q14331	FRG1_HUMAN	FSHD region gene 1	90					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus				NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		AGTTGATGAGGGCCCTAGTCC	0.284000													3	35					0	0	1	0	0
PCDHA9	0	broad.mit.edu	37	5	140228379	140228379	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr5:140228379C>T	ENST00000378122.3	+	1	1023	c.299C>T	c.(298-300)gCg>gTg	p.A100V	PCDHA9_ENST00000532602.1_Missense_Mutation_p.A100V|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCGGAGCGCGGAGTGCAGC	0.567000													21	123					0	0	1	0	0
ARHGEF38	54848	broad.mit.edu	37	4	106473931	106473931	+	Silent	SNP	C	C	T			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr4:106473931C>T	ENST00000420470.2	+	1	153	c.9C>T	c.(7-9)ccC>ccT	p.P3P	ARHGEF38_ENST00000265154.2_Silent_p.P3P	NM_001242729.1	NP_001229658.1	Q9NXL2	ARH38_HUMAN	Rho guanine nucleotide exchange factor (GEF) 38	3					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(3)	11						ATATGGAGCCCAAAGAAGCCA	0.473000													4	72					0	0	1	0	0
RBMS3	27303	broad.mit.edu	37	3	30029706	30029706	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr3:30029706T>C	ENST00000434693.2	+	13	1868	c.1168T>C	c.(1168-1170)Tct>Cct	p.S390P	RBMS3_ENST00000456853.1_Missense_Mutation_p.S388P|RBMS3_ENST00000383767.2_Missense_Mutation_p.S391P|RBMS3_ENST00000383766.2_Missense_Mutation_p.S373P|RBMS3_ENST00000396583.3_Missense_Mutation_p.S388P|RBMS3_ENST00000473799.1_3'UTR|RBMS3_ENST00000452462.1_Missense_Mutation_p.S375P|RBMS3_ENST00000273139.9_Missense_Mutation_p.S375P	NM_001003793.2	NP_001003793.1	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting protein 3	391						cytoplasm	nucleotide binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	11		Ovarian(412;0.0956)				GACAGCTGTTTCTATTGAAGT	0.423000													5	18					0	0	1	0	0
P2RY14	9934	broad.mit.edu	37	3	150931217	150931217	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr3:150931217G>T	ENST00000309170.3	-	3	1200	c.888C>A	c.(886-888)ttC>ttA	p.F296L	P2RY14_ENST00000424796.2_Missense_Mutation_p.F296L|MED12L_ENST00000474524.1_Intron|MED12L_ENST00000273432.4_Intron	NM_001081455.1|NM_014879.3	NP_001074924.1|NP_055694.3	Q15391	P2Y14_HUMAN	purinergic receptor P2Y, G-protein coupled, 14	296						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(1)	20			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGCATAGAAAGAAATAAATAA	0.363000													16	69					0.000422831	0.000430519	1	1	0
ALK	238	broad.mit.edu	37	2	29917842	29917842	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr2:29917842A>C	ENST00000389048.3	-	3	1732	c.826T>G	c.(826-828)Tat>Gat	p.Y276D	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	276	MAM 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GGAGGGGAATACTCCAGCTCA	0.577000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				15	48					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134034812	134034812	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr9:134034812G>A	ENST00000359428.5	+	18	2623	c.2479G>A	c.(2479-2481)Gat>Aat	p.D827N	RP11-544A12.4_ENST00000587408.1_RNA|RP11-544A12.4_ENST00000589667.1_RNA|RP11-544A12.4_ENST00000589128.1_RNA|RP11-544A12.4_ENST00000590461.1_RNA|RP11-544A12.4_ENST00000417798.2_RNA|RP11-544A12.4_ENST00000586290.1_RNA|RP11-544A12.4_ENST00000415391.2_RNA|NUP214_ENST00000451030.1_Missense_Mutation_p.D828N|RP11-544A12.4_ENST00000589540.1_RNA|NUP214_ENST00000411637.2_Missense_Mutation_p.D817N|RP11-544A12.4_ENST00000587264.1_RNA|RP11-544A12.4_ENST00000588378.1_RNA			P35658	NU214_HUMAN	nucleoporin 214kDa	827	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TGCTGTCCAAGATGTGAATGA	0.363000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								10	29					0	0	1	0	0
IGKV2-30	0	broad.mit.edu	37	2	89544412	89544412	+	RNA	SNP	C	C	T			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr2:89544412C>T	ENST00000468494.1	-	0	241																											ATAAATTAGGCGCCTTGGAGA	0.522000													30	97					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152327955	152327955	+	Silent	SNP	G	G	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr1:152327955G>A	ENST00000388718.5	-	3	2379	c.2307C>T	c.(2305-2307)agC>agT	p.S769S	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	769	Ser-rich.						calcium ion binding|structural molecule activity	p.S769S(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTTGGCCATAGCTAGACTGAC	0.517000													7	318					0	0	1	0	0
RHOA	387	broad.mit.edu	37	3	49412958	49412958	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr3:49412958A>C	ENST00000418115.1	-	2	449	c.65T>G	c.(64-66)cTc>cGc	p.L22R	RHOA_ENST00000454011.2_Missense_Mutation_p.L22R|RHOA_ENST00000422781.1_Missense_Mutation_p.L22R	NM_001664.2	NP_001655.1	P61586	RHOA_HUMAN	ras homolog family member A	22					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			cervix(1)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	GAAGACTATGAGCAAGCATGT	0.473000													21	89					0	0	1	0	0
B9D1	27077	broad.mit.edu	37	17	19247157	19247157	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr17:19247157G>A	ENST00000461069.2	-	6	462	c.418C>T	c.(418-420)Cgg>Tgg	p.R140W	B9D1_ENST00000395615.1_Missense_Mutation_p.R140W|B9D1_ENST00000477478.2_Silent_p.G115G|B9D1_ENST00000395616.3_Missense_Mutation_p.R140W|B9D1_ENST00000261499.4_Missense_Mutation_p.R140W|B9D1_ENST00000575403.1_Silent_p.G115G			Q9UPM9	B9D1_HUMAN	B9 protein domain 1	140					cilium assembly	centrosome|microtubule basal body	protein binding	p.R140W(1)		large_intestine(3)|urinary_tract(1)	4	all_cancers(12;2.04e-05)|all_epithelial(12;0.000806)|Hepatocellular(7;0.00345)|Breast(13;0.143)					TCGGGCCGCCGCCCCATGAAC	0.617000													7	34					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	48					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810767	7810767	+	Missense_Mutation	SNP	G	G	A	rs146082308		TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr19:7810767G>A	ENST00000315599.7	-	4	407	c.385C>T	c.(385-387)Cgg>Tgg	p.R129W	CD209_ENST00000301357.8_Missense_Mutation_p.R85W|CD209_ENST00000601951.1_Missense_Mutation_p.R105W|CD209_ENST00000204801.8_Missense_Mutation_p.R85W|CD209_ENST00000593821.1_Missense_Mutation_p.R85W|CD209_ENST00000593660.1_Missense_Mutation_p.R105W|CD209_ENST00000354397.6_Missense_Mutation_p.R129W|CD209_ENST00000394161.5_Intron|CD209_ENST00000394173.4_Intron|CD209_ENST00000601256.1_Missense_Mutation_p.R105W|CD209_ENST00000315591.8_Missense_Mutation_p.R105W|CD209_ENST00000602261.1_Missense_Mutation_p.R129W	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	129	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding	p.R129W(4)		endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GCCTTCAGCCGGGTCAGCTCC	0.567000													5	124					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55450938	55450938	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr19:55450938G>A	ENST00000588756.1	-	6	1735	c.1249C>T	c.(1249-1251)Ctc>Ttc	p.L417F	NLRP7_ENST00000592784.1_Missense_Mutation_p.L417F|NLRP7_ENST00000590030.1_Missense_Mutation_p.L417F|NLRP7_ENST00000328092.5_Missense_Mutation_p.L417F|NLRP7_ENST00000340844.2_Missense_Mutation_p.L417F|NLRP7_ENST00000446217.1_Missense_Mutation_p.L445F|NLRP7_ENST00000448121.2_Missense_Mutation_p.L417F			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	417	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		GCGGCCAGGAGGCTCAGCGTC	0.706000													6	24					0	0	1	0	0
TMEM145	284339	broad.mit.edu	37	19	42821926	42821926	+	Silent	SNP	G	G	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr19:42821926G>A	ENST00000598766.1	+	12	1038	c.1038G>A	c.(1036-1038)ctG>ctA	p.L346L	TMEM145_ENST00000301204.3_Silent_p.L322L			Q8NBT3	TM145_HUMAN	transmembrane protein 145	322						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				TCATTGGACTGCAGGTGGCGG	0.567000													3	43					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	45209834	45209834	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr12:45209834C>A	ENST00000429094.2	-	3	774	c.270G>T	c.(268-270)ttG>ttT	p.L90F	NELL2_ENST00000547172.1_5'UTR|NELL2_ENST00000551601.1_Missense_Mutation_p.L89F|NELL2_ENST00000548826.1_Missense_Mutation_p.L90F|NELL2_ENST00000549027.1_Missense_Mutation_p.L89F|NELL2_ENST00000395487.2_Missense_Mutation_p.L89F|NELL2_ENST00000333837.4_Missense_Mutation_p.L113F|NELL2_ENST00000452445.2_Missense_Mutation_p.L90F|NELL2_ENST00000437801.2_Missense_Mutation_p.L140F	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	90	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TTAGGGTCACCAAAATAGTAA	0.368000													21	71					3.62473e-10	3.82991e-10	1	1	0
PRAMEF11	440560	broad.mit.edu	37	1	12887686	12887686	+	Silent	SNP	T	T	C	rs59802947	by1000genomes	TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr1:12887686T>C	ENST00000535591.1	-	3	366	c.171A>G	c.(169-171)agA>agG	p.R57R		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	57								p.R57R(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GAAGTTTCCATCTCCTGTGGG	0.468000													6	174					0	0	1	0	0
TROVE2	6738	broad.mit.edu	37	1	193038185	193038185	+	Translation_Start_Site	SNP	A	A	T			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr1:193038185A>T	ENST00000416058.2	+	0	371				TROVE2_ENST00000367441.1_Start_Codon_SNP_p.M1L|TROVE2_ENST00000367443.1_Start_Codon_SNP_p.M1L|TROVE2_ENST00000367444.3_Start_Codon_SNP_p.M1L|TROVE2_ENST00000460715.2_Intron|TROVE2_ENST00000432079.1_Intron|TROVE2_ENST00000367446.3_Start_Codon_SNP_p.M1L|TROVE2_ENST00000400968.2_Start_Codon_SNP_p.M1L|TROVE2_ENST00000367445.3_Start_Codon_SNP_p.M1L			P10155	RO60_HUMAN	TROVE domain family, member 2						transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding			biliary_tract(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|urinary_tract(1)	21						ACAAAAAAAAATGGAGGAATC	0.353000													6	25					0	0	1	0	0
HADHB	3032	broad.mit.edu	37	2	26492860	26492860	+	Silent	SNP	G	G	A			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr2:26492860G>A	ENST00000317799.5	+	5	353	c.249G>A	c.(247-249)gcG>gcA	p.A83A	HADHB_ENST00000545822.1_Silent_p.A61A|HADHB_ENST00000537713.1_Intron|HADHB_ENST00000405867.3_Silent_p.A83A|HADHB_ENST00000494615.1_3'UTR	NM_000183.2	NP_000174.1	P55084	ECHB_HUMAN	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	83					fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTAGAGCAGCGCTTACGTAAG	0.343000													9	64					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93800893	93800893	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr11:93800893G>T	ENST00000315765.9	+	5	1048	c.1040G>T	c.(1039-1041)tGc>tTc	p.C347F		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	347	Plastocyanin-like 2.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				ATGATAACCTGCCAGGTCAGC	0.468000													10	31					2.74318e-10	2.95419e-10	1	1	0
BRPF1	7862	broad.mit.edu	37	3	9782470	9782470	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr3:9782470delA	ENST00000383829.2	+	4	1971	c.1567delA	c.(1567-1569)aafs	p.K523fs	BRPF1_ENST00000457855.1_Frame_Shift_Del_p.K523fs|BRPF1_ENST00000433861.2_Frame_Shift_Del_p.K523fs|BRPF1_ENST00000424362.1_Frame_Shift_Del_p.K523fs|BRPF1_ENST00000302054.3_Frame_Shift_Del_p.K523fs	NM_001003694.1	NP_001003694.1	P55201	BRPF1_HUMAN	bromodomain and PHD finger containing, 1	523	Interaction with MEAF6 and ING5.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	49	Medulloblastoma(99;0.227)					CAGGCTTAGTAAAATCACCAA	0.522													16	67	---	---	---	---					
KCNN2	3781	broad.mit.edu	37	5	113698631	113698632	+	In_Frame_Ins	INS	-	-	GCC	rs34838882	by1000genomes	TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr5:113698631_113698632insGCC	ENST00000512097.3	+	2	1177_1178	c.159_160insGCC	c.(157-162)gcccgc>gcGCCccgc	p.53_54AR>APR	KCNN2_ENST00000264773.3_In_Frame_Ins_p.53_54AR>APR			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	53	Poly-Ala.					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		CTGCAGCCGCTGCCGCCGCCGC	0.703													5	7	---	---	---	---					
FLT1	2321	broad.mit.edu	37	13	29068965	29068965	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr13:29068965delC	ENST00000282397.4	-	1	267	c.16delG	c.(16-18)acfs	p.D6fs	FLT1_ENST00000539099.1_Frame_Shift_Del_p.D6fs|FLT1_ENST00000541932.1_Frame_Shift_Del_p.D6fs	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	6					cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	ACCCCGGTGTCCCAGTAGCTG	0.751													2	4	---	---	---	---					
CHRNA3	0	broad.mit.edu	37	15	78913068	78913070	+	In_Frame_Del	DEL	CAG	CAG	-	rs72025661		TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr15:78913068_78913070delCAG	ENST00000326828.5	-	1	451_453	c.67_69delCTG	c.(67-69)del	p.L23del	CHRNA3_ENST00000348639.3_In_Frame_Del_p.L23del	NM_000743.4	NP_000734.2	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3 (neuronal)	23			Missing.		activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						gcagcagagacagcagcagcagc	0.768													2	4	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZG-A9LY-01A-11D-A41K-08	TCGA-ZG-A9LY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a1f1c7e-8d3b-4323-a37d-767b65089dbf	5c2da700-8b1e-4ca3-8960-f8f0028ca0d8	g.chr17:45219612delA	ENST00000066544.3	-	11	1454	c.1361delT	c.(1360-1362)cafs	p.L454fs	CDC27_ENST00000446365.2_Frame_Shift_Del_p.L393fs|CDC27_ENST00000531206.1_Frame_Shift_Del_p.L460fs|CDC27_ENST00000527547.1_Frame_Shift_Del_p.L454fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	454					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308													7	35	---	---	---	---