Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
FZD5	0	genome.wustl.edu	37	2	208632893	208632893	+	Nonsense_Mutation	SNP	T	T	A			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	2	208632893	208632893	T	A	SNP	FZD5	ENST00000295417	human	ensembl	74_37	-1	known	nonsense	c.571	p.K191*	1.000	NULL	pfam_Frizzled,pfam_Frizzled_dom,superfamily_Frizzled_dom,smart_Frizzled_dom,pfscan_Frizzled_dom,pfscan_GPCR_2-like,prints_Frizzled	-	no_errors	FZD5	HGNC	ENSG00000163251	tier1	-	-	53	0	0.00	21	14	40.00	41	0	0.00	23	13	36.11
BARHL2	0	genome.wustl.edu	37	1	91180171	91180171	+	Silent	SNP	G	G	A			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	1	91180171	91180171	G	A	SNP	BARHL2	ENST00000370445	human	ensembl	74_37	-1	known	silent	c.768	p.Y256	1.000	pfam_Homeobox_dom,superfamily_Homeodomain-like,smart_Homeobox_dom,pfscan_Homeobox_dom,prints_Homeobox_metazoa	pfam_Homeobox_dom,superfamily_Homeodomain-like,smart_Homeobox_dom,pfscan_Homeobox_dom,prints_Homeobox_metazoa	-	no_errors	BARHL2	HGNC	ENSG00000143032	tier1	-	-	75	0	0.00	42	13	23.64	46	0	0.00	32	9	21.95
STEAP1	0	genome.wustl.edu	37	7	89791383	89791383	+	Missense_Mutation	SNP	C	C	G			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	7	89791383	89791383	C	G	SNP	STEAP1	ENST00000297205	human	ensembl	74_37	+1	known	missense	c.753	p.H251Q	0.969	pfam_Fe3_Rdtase_TM_dom	pfam_Fe3_Rdtase_TM_dom	-	no_errors	STEAP1	HGNC	ENSG00000164647	tier1	-	-	109	0	0.00	65	26	28.57	64	0	0.00	41	16	28.07
RBM6	0	genome.wustl.edu	37	3	50005514	50005514	+	Missense_Mutation	SNP	A	A	C			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	3	50005514	50005514	A	C	SNP	RBM6	ENST00000266022	human	ensembl	74_37	+1	known	missense	c.656	p.D219A	0.978	NULL	pfam_G_patch_dom,smart_RRM_dom,smart_G_patch_dom,pfscan_G_patch_dom,pfscan_RRM_dom	-	no_errors	RBM6	HGNC	ENSG00000004534	tier1	-	-	39	0	0.00	20	7	25.93	139	0	0.00	78	63	44.68
SCN2A	0	genome.wustl.edu	37	2	166187935	166187935	+	Missense_Mutation	SNP	A	A	G			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	2	166187935	166187935	A	G	SNP	SCN2A	ENST00000283256	human	ensembl	74_37	+1	known	missense	c.2245	p.K749E	1.000	NULL	pfam_Ion_trans_dom,pfam_Na_trans_assoc,pfam_DUF3451,pfam_PKD1_2_channel,smart_IQ_motif_EF-hand-BS,prints_Na_channel_asu,prints_PKD_2,pfscan_IQ_motif_EF-hand-BS	-	no_errors	SCN2A	HGNC	ENSG00000136531	tier1	-	-	71	0	0.00	50	36	41.86	123	0	0.00	54	47	46.08
GRIA1	0	genome.wustl.edu	37	5	152873487	152873487	+	Splice_Site	SNP	G	G	A			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	5	152873487	152873487	G	A	SNP	GRIA1	ENST00000448073	human	ensembl	74_37	+1	known	splice_site	c.113-1	e2-1	1.000	-	-	-	no_errors	GRIA1	HGNC	ENSG00000155511	tier1	-	-	49	0	0.00	28	4	12.50	79	0	0.00	45	6	11.54
KCNK10	0	genome.wustl.edu	37	14	88652154	88652154	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	14	88652154	88652154	C	T	SNP	KCNK10	ENST00000312350	human	ensembl	74_37	-1	known	missense	c.1357	p.G453R	1.000	NULL	pfam_2pore_dom_K_chnl_dom,prints_2pore_dom_K_chnl_TREK,prints_2pore_dom_K_chnl,prints_2pore_dom_K_chnl_TRAAK,prints_2pore_dom_K_chnl_TASK	-	no_errors	KCNK10	HGNC	ENSG00000100433	tier1	-	-	141	0	0.00	39	30	43.48	114	0	0.00	29	30	50.85
KIF27	0	genome.wustl.edu	37	9	86530369	86530369	+	Silent	SNP	A	A	C			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	9	86530369	86530369	A	C	SNP	KIF27	ENST00000297814	human	ensembl	74_37	-1	known	silent	c.138	p.T46	0.998	pfam_Kinesin_motor_dom,superfamily_P-loop_NTPase,smart_Kinesin_motor_dom,pfscan_Kinesin_motor_dom	pfam_Kinesin_motor_dom,superfamily_P-loop_NTPase,smart_Kinesin_motor_dom,pfscan_Kinesin_motor_dom,prints_Kinesin_motor_dom	-	no_errors	KIF27	HGNC	ENSG00000165115	tier1	-	-	142	0	0.00	111	21	15.79	86	0	0.00	75	19	20.21
THTPA	0	genome.wustl.edu	37	14	24028936	24028936	+	R	SNP	T	T	A			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	14	24028936	24028936	T	A	SNP	THTPA	ENST00000553985	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.011	-	-	-	no_errors	RP11-66N24.4	Clone_based_vega_gene	ENSG00000157306	tier1	-	-	27	0	0.00	18	4	18.18	99	0	0.00	91	19	17.27
FRMPD4	0	genome.wustl.edu	37	X	12736131	12736131	+	Missense_Mutation	SNP	T	T	G			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	X	12736131	12736131	T	G	SNP	FRMPD4	ENST00000380682	human	ensembl	74_37	+1	known	missense	c.3186	p.S1062R	0.624	NULL	pfam_FERM_central,pfam_PDZ,superfamily_FERM_central,superfamily_PDZ,smart_PDZ,smart_Band_41_domain,pfscan_FERM_domain,pfscan_PDZ,pfscan_WW_dom	-	no_errors	FRMPD4	HGNC	ENSG00000169933	tier1	-	-	11	0	0.00	9	13	59.09	78	0	0.00	43	31	41.89
TRPM1	0	genome.wustl.edu	37	15	31339353	31339353	+	Silent	SNP	G	G	A			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	15	31339353	31339353	G	A	SNP	TRPM1	ENST00000542188	human	ensembl	74_37	-1	known	silent	c.1776	p.N592	0.749	NULL	pfam_Ion_trans_dom	-	no_errors	TRPM1	HGNC	ENSG00000134160	tier1	-	-	87	0	0.00	43	29	39.73	110	0	0.00	71	31	30.39
BAHCC1	0	genome.wustl.edu	37	17	79426613	79426613	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	17	79426613	79426613	C	T	SNP	BAHCC1	ENST00000307745	human	ensembl	74_37	+1	known	missense	c.5888	p.P1963L	0.998	NULL	pfam_BAH_dom,smart_BAH_dom,pfscan_BAH_dom	-	no_errors	RP11-1055B8.7	Clone_based_vega_gene	ENSG00000171282	tier1	-	-	69	0	0.00	23	28	53.85	51	0	0.00	29	34	53.97
HIPK1	0	genome.wustl.edu	37	1	114515911	114515911	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	1	114515911	114515911	G	A	SNP	HIPK1	ENST00000369558	human	ensembl	74_37	+1	known	missense	c.3410	p.G1137D	1.000	NULL	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	HIPK1	HGNC	ENSG00000163349	tier1	-	-	34	0	0.00	29	22	43.14	59	0	0.00	33	34	50.75
FCGBP	0	genome.wustl.edu	37	19	40363977	40363977	+	Missense_Mutation	SNP	T	T	G			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	19	40363977	40363977	T	G	SNP	FCGBP	ENST00000221347	human	ensembl	74_37	-1	known	missense	c.14665	p.K4889Q	0.000	pfam_VWF_type-D,smart_VWF_type-D	pfam_VWF_type-D,pfam_Unchr_dom_Cys-rich,pfam_TIL_dom,superfamily_TIL_dom,smart_Fol_N,smart_VWF_type-D,smart_Unchr_dom_Cys-rich,smart_EG-like_dom,smart_VWF_C,smart_VWC_out	-	no_errors	FCGBP	HGNC	ENSG00000090920	tier1	-	-	58	0	0.00	29	25	46.30	104	0	0.00	77	57	42.54
FAM46A	0	genome.wustl.edu	37	6	82459945	82459945	+	Missense_Mutation	SNP	C	C	G			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	6	82459945	82459945	C	G	SNP	FAM46A	ENST00000369754	human	ensembl	74_37	-1	known	missense	c.853	p.G285R	1.000	pfam_DUF1693	pfam_DUF1693	-	no_errors	FAM46A	HGNC	ENSG00000112773	tier1	-	-	55	0	0.00	23	21	47.73	91	0	0.00	48	37	43.02
RXFP3	0	genome.wustl.edu	37	5	33937261	33937261	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	5	33937261	33937261	C	T	SNP	RXFP3	ENST00000330120	human	ensembl	74_37	+1	known	missense	c.416	p.A139V	1.000	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Formyl_pep_rcpt	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_GPCR_Rhodpsn,prints_Formyl_pep_rcpt	-	no_errors	RXFP3	HGNC	ENSG00000182631	tier1	-	-	46	0	0.00	21	18	46.15	102	0	0.00	64	40	38.46
SCFD1	0	genome.wustl.edu	37	14	31091601	31091601	+	Silent	SNP	G	G	A			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	14	31091601	31091601	G	A	SNP	SCFD1	ENST00000458591	human	ensembl	74_37	+1	known	silent	c.57	p.Q19	1.000	superfamily_Sec1-like	pfam_Sec1-like,superfamily_Sec1-like	-	no_errors	SCFD1	HGNC	ENSG00000092108	tier1	-	-	92	0	0.00	44	35	44.30	79	0	0.00	29	40	57.97
KDELC1	0	genome.wustl.edu	37	13	103436678	103436678	+	R	SNP	T	T	A			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	13	103436678	103436678	T	A	SNP	KDELC1	ENST00000460338	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.121	-	-	-	no_errors	KDELC1	HGNC	ENSG00000134901	tier1	-	-	26	0	0.00	14	10	41.67	23	0	0.00	14	14	50.00
TRIOBP	0	genome.wustl.edu	37	22	38155238	38155238	+	Silent	SNP	G	G	A			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	22	38155238	38155238	G	A	SNP	TRIOBP	ENST00000406386	human	ensembl	74_37	+1	known	silent	c.6291	p.E2097	0.999	NULL	pfam_Pleckstrin_homology,smart_Pleckstrin_homology,pfscan_Pleckstrin_homology	-	no_errors	TRIOBP	HGNC	ENSG00000100106	tier1	-	-	38	0	0.00	12	21	63.64	35	0	0.00	22	19	45.24
LGALS12	0	genome.wustl.edu	37	11	63276351	63276351	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	11	63276351	63276351	G	C	SNP	LGALS12	ENST00000340246	human	ensembl	74_37	+1	known	missense	c.329	p.C110S	1.000	pfam_Galectin_CRD,superfamily_ConA-like_lec_gl_sf,smart_Galectin_CRD	pfam_Galectin_CRD,superfamily_ConA-like_lec_gl_sf,smart_Galectin_CRD	-	no_errors	LGALS12	HGNC	ENSG00000133317	tier1	-	-	49	0	0.00	23	16	41.03	58	0	0.00	41	25	37.88
HIPK1	0	genome.wustl.edu	37	1	114512653	114512653	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	1	114512653	114512653	G	C	SNP	HIPK1	ENST00000369558	human	ensembl	74_37	+1	known	missense	c.2847	p.L949F	1.000	NULL	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	HIPK1	HGNC	ENSG00000163349	tier1	-	-	79	0	0.00	56	33	37.08	94	0	0.00	45	33	42.31
UNC13A	0	genome.wustl.edu	37	19	17740964	17740964	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	19	17740964	17740964	C	T	SNP	UNC13A	ENST00000428389	human	ensembl	74_37	-1	known	missense	c.3923	p.R1308H	1.000	NULL	pfam_Munc13_subgr_dom-2,pfam_C2_dom,pfam_Ca-dep_secretion_activator,pfam_Prot_Kinase_C-like_PE/DAG-bd,superfamily_C2_dom,smart_C2_dom,smart_Prot_Kinase_C-like_PE/DAG-bd,pfscan_C2_dom,pfscan_Prot_Kinase_C-like_PE/DAG-bd,prints_C2_dom	-	no_errors	UNC13A	HGNC	ENSG00000130477	tier1	-	-	39	0	0.00	32	12	27.27	110	0	0.00	82	52	38.81
ATM	0	genome.wustl.edu	37	11	108159802	108159802	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	11	108159802	108159802	G	T	SNP	ATM	ENST00000278616	human	ensembl	74_37	+1	known	missense	c.4208	p.S1403I	1.000	superfamily_ARM-type_fold	pfam_PIK-rel_kinase_FAT,pfam_PI3/4_kinase_cat_dom,pfam_TAN,pfam_FATC,superfamily_Kinase-like_dom,superfamily_ARM-type_fold,smart_PI3/4_kinase_cat_dom,pfscan_PIK_FAT,pfscan_FATC,pfscan_PI3/4_kinase_cat_dom	-	no_errors	ATM	HGNC	ENSG00000149311	tier1	-	-	68	0	0.00	51	12	19.05	108	0	0.00	76	23	22.33
PRDM15	0	genome.wustl.edu	37	21	43230531	43230531	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	21	43230531	43230531	G	T	SNP	PRDM15	ENST00000269844	human	ensembl	74_37	-1	known	missense	c.3729	p.H1243Q	1.000	smart_Znf_C2H2-like	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_SET_dom,pfscan_Znf_C2H2	-	no_errors	PRDM15	HGNC	ENSG00000141956	tier1	-	-	29	0	0.00	22	4	15.38	11	0	0.00	15	2	11.76
ACOT13	0	genome.wustl.edu	37	6	24687908	24687908	+	R	DEL	A	A	-			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	A	A	A	-	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	6	24687908	24687908	A	-	DEL	ACOT13	ENST00000476436	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.636	-	-	-	no_errors	ACOT13	HGNC	ENSG00000112304	tier1			24	0	0.00	18	12	40.00	34	0	0.00	23	10	30.30
ARFGEF1	0	genome.wustl.edu	37	8	68172143	68172144	+	Frame_Shift_Ins	INS	-	-	TT			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	-	-	-	TT	-	-	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	8	68172143	68172144	-	TT	INS	ARFGEF1	ENST00000262215	human	ensembl	74_37	-1	known	frame_shift_ins	c.2142_2141	p.G716fs	1.000:1.000	pfam_Sec7_dom,superfamily_Sec7_dom,superfamily_ARM-type_fold,smart_Sec7_dom,pfscan_Sec7_dom	pfam_Sec7_dom,pfam_DUF1981_Sec7_assoc,superfamily_Sec7_dom,superfamily_ARM-type_fold,smart_Sec7_dom,pfscan_Sec7_dom	-	no_errors	ARFGEF1	HGNC	ENSG00000066777	tier1			84	0	0.00	36	23	38.98	121	0	0.00	81	45	35.71
ATM	0	genome.wustl.edu	37	11	108159797	108159797	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	A	A	A	-	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	11	108159797	108159797	A	-	DEL	ATM	ENST00000278616	human	ensembl	74_37	+1	known	frame_shift_del	c.4203	p.S1403fs	0.201	superfamily_ARM-type_fold	pfam_PIK-rel_kinase_FAT,pfam_PI3/4_kinase_cat_dom,pfam_TAN,pfam_FATC,superfamily_Kinase-like_dom,superfamily_ARM-type_fold,smart_PI3/4_kinase_cat_dom,pfscan_PIK_FAT,pfscan_FATC,pfscan_PI3/4_kinase_cat_dom	-	no_errors	ATM	HGNC	ENSG00000149311	tier1			71	0	0.00	51	12	19.05	113	0	0.00	77	22	22.22
GSTA5	0	genome.wustl.edu	37	6	52705543	52705543	+	Silent	SNP	C	C	G			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	6	52705543	52705543	C	G	SNP	GSTA5	ENST00000284562	human	ensembl	74_37	-1	known	silent	c.69	p.L23	1.000	pfam_Glutathione_S-Trfase_N,superfamily_Thioredoxin-like_fold,prints_GST_alpha	pfam_Glutathione_S-Trfase_N,pfam_GST_C,superfamily_Glutathione-S-Trfase_C-like,superfamily_Thioredoxin-like_fold,prints_GST_alpha	-	no_errors	GSTA5	HGNC	ENSG00000182793	tier1	-	-	67	0	0.00	31	18	36.73	19	0	0.00	8	9	52.94
PCNXL3	0	genome.wustl.edu	37	11	65402801	65402801	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	11	65402801	65402801	G	A	SNP	PCNXL3	ENST00000355703	human	ensembl	74_37	+1	known	missense	c.5066	p.S1689N	1.000	pfam_Pecanex	pfam_Pecanex	-	no_errors	PCNXL3	HGNC	ENSG00000197136	tier1	-	-	10	0	0.00	14	9	39.13	5	0	0.00	6	3	33.33
TP53	0	genome.wustl.edu	37	17	7577114	7577114	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	17	7577114	7577114	C	T	SNP	TP53	ENST00000269305	human	ensembl	74_37	-1	known	missense	c.824	p.C275Y	1.000	pfam_p53_D-bd,superfamily_p53-like_TF_D-bd,prints_p53_tumour_suppressor	pfam_p53_D-bd,pfam_p53_tetrameristn,pfam_p53_transactivation_domain,superfamily_p53-like_TF_D-bd,superfamily_p53_tetrameristn,prints_p53_tumour_suppressor	-	no_errors	TP53	HGNC	ENSG00000141510	tier1	-	-	51	0	0.00	3	19	82.61	113	0	0.00	4	51	89.47
FAM230C	0	genome.wustl.edu	37	22	21663186	21663187	+	R	INS	-	-	TAGCGA			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	22	21663186	21663187	-	TAGCGA	INS	FAM230C	ENST00000436681	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.002:0.008	-	-	-	no_errors	KB-1183D5.13	Clone_based_vega_gene	ENSG00000206142	tier1			0	0	0.00	2	0	0.00	0	0	0.00	2	0	0.00
FAM86B2	0	genome.wustl.edu	37	8	12293822	12293822	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	8	12293822	12293822	G	T	SNP	FAM86B2	ENST00000262365	human	ensembl	74_37	-1	known	missense	c.31	p.L11I	0.397	NULL	pfam_Nicotinamide_N-MeTfrase-like	-	no_errors	FAM86B2	HGNC	ENSG00000145002	tier1	-	-	50	0	0.00	36	8	18.18	2	0	0.00	1	0	0.00
CLCN1	0	genome.wustl.edu	37	7	143042676	143042676	+	Silent	SNP	C	C	T			TCGA-DX-A6B7-01A-11D-A307-09	TCGA-DX-A6B7-10A-01D-A307-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	fe12005c-6c77-45ca-a85d-e85367fa7567	6aff930d-fe20-4689-9af5-f730e5d138e0	7	143042676	143042676	C	T	SNP	CLCN1	ENST00000343257	human	ensembl	74_37	+1	known	silent	c.1993	p.L665	0.998	NULL	pfam_Cl-channel_volt-gated,pfam_CBS_dom,superfamily_Cl-channel_core,prints_Cl-channel_volt-gated,prints_Cl_channel-1	-	no_errors	CLCN1	HGNC	ENSG00000188037	tier1	-	-	174	0	0.00	87	62	41.61	4	0	0.00	3	2	40.00