Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
EXOSC7	0	genome.wustl.edu	37	3	45048925	45048925	+	Missense_Mutation	SNP	A	A	T			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	3	45048925	45048925	A	T	SNP	EXOSC7	ENST00000265564	human	ensembl	74_37	+1	known	missense	c.629	p.H210L	1.000	pfam_ExoRNase_PH_dom2,superfamily_ExoRNase_PH_dom2	pfam_ExoRNase_PH_dom1,pfam_ExoRNase_PH_dom2,superfamily_Ribosomal_S5_D2-typ_fold,superfamily_ExoRNase_PH_dom2	-	no_errors	EXOSC7	HGNC	ENSG00000075914	tier1	-	-	53	0	0.00	62	7	10.14	57	1	1.72	29	5	14.71
IL1RAPL1	0	genome.wustl.edu	37	X	29301312	29301312	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	X	29301312	29301312	G	A	SNP	IL1RAPL1	ENST00000302196	human	ensembl	74_37	+1	known	missense	c.340	p.G114S	1.000	smart_Ig_sub,pfscan_Ig-like_dom	pfam_TIR_dom,pfam_Ig_I-set,pfam_Immunoglobulin,superfamily_TIR_dom,smart_Ig_sub,smart_Ig_sub2,smart_TIR_dom,pfscan_TIR_dom,pfscan_Ig-like_dom	-	no_errors	IL1RAPL1	HGNC	ENSG00000169306	tier1	-	-	52	0	0.00	46	4	8.00	40	0	0.00	46	6	11.54
PROZ	0	genome.wustl.edu	37	13	113826312	113826312	+	Missense_Mutation	SNP	T	T	C			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	13	113826312	113826312	T	C	SNP	PROZ	ENST00000375547	human	ensembl	74_37	+1	known	missense	c.1096	p.F366L	1.000	pirsf_Pept_S1A_FX,pfam_Peptidase_S1,superfamily_Trypsin-like_Pept_dom,smart_Peptidase_S1,pfscan_Peptidase_S1	pirsf_Pept_S1A_FX,pfam_Peptidase_S1,pfam_GLA_domain,pfam_EG-like_dom,superfamily_Trypsin-like_Pept_dom,superfamily_GLA_domain,smart_GLA_domain,smart_EG-like_dom,smart_EGF-like_Ca-bd_dom,smart_Peptidase_S1,prints_GLA_domain,pfscan_EG-like_dom,pfscan_GLA_domain,pfscan_Peptidase_S1	-	no_errors	PROZ	HGNC	ENSG00000126231	tier1	-	-	95	0	0.00	100	22	17.74	82	0	0.00	68	11	13.92
FREM2	0	genome.wustl.edu	37	13	39265060	39265060	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	13	39265060	39265060	G	A	SNP	FREM2	ENST00000280481	human	ensembl	74_37	+1	known	missense	c.3579	p.M1193I	0.970	superfamily_Cadherin-like	pfam_Calx_beta,superfamily_Cadherin-like,smart_Calx_beta	-	no_errors	FREM2	HGNC	ENSG00000150893	tier1	-	-	75	0	0.00	60	13	17.81	101	0	0.00	70	13	15.66
GNB2L1	0	genome.wustl.edu	37	5	180670201	180670201	+	R	SNP	G	G	A			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	5	180670201	180670201	G	A	SNP	GNB2L1	ENST00000514318	human	ensembl	74_37	-1	putative	rna	NULL	NULL	0.003	-	-	-	no_errors	GNB2L1	HGNC	ENSG00000204628	tier1	-	-	58	0	0.00	45	4	8.16	67	0	0.00	81	14	14.74
ZNF521	0	genome.wustl.edu	37	18	22804482	22804482	+	Missense_Mutation	SNP	C	C	G			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	18	22804482	22804482	C	G	SNP	ZNF521	ENST00000361524	human	ensembl	74_37	-1	known	missense	c.3400	p.G1134R	0.992	NULL	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	ZNF521	HGNC	ENSG00000198795	tier1	-	-	115	0	0.00	123	17	12.14	58	0	0.00	86	10	10.42
ZNF710	0	genome.wustl.edu	37	15	90617472	90617472	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	15	90617472	90617472	G	A	SNP	ZNF710	ENST00000268154	human	ensembl	74_37	+1	known	missense	c.1775	p.R592Q	1.000	smart_Znf_C2H2-like,pfscan_Znf_C2H2	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	ZNF710	HGNC	ENSG00000140548	tier1	-	-	41	0	0.00	40	4	9.09	41	0	0.00	15	6	28.57
C1orf173	0	genome.wustl.edu	37	1	75078322	75078322	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	G	G	G	-	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	1	75078322	75078322	G	-	DEL	C1orf173	ENST00000326665	human	ensembl	74_37	-1	known	frame_shift_del	c.1172	p.S391fs	1.000	NULL	NULL	-	no_errors	C1orf173	HGNC	ENSG00000178965	tier1			107	0	0.00	111	20	15.27	149	0	0.00	101	22	17.89
A40	0	genome.wustl.edu	37	11	63720082	63720082	+	R	SNP	G	G	A			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	11	63720082	63720082	G	A	SNP	A40	ENST00000536939	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.002	-	-	-	no_errors	A40	HGNC	ENSG00000110583	tier1	-	-	65	0	0.00	91	8	8.08	57	0	0.00	42	4	8.70
CSMD2	0	genome.wustl.edu	37	1	34002679	34002679	+	Silent	SNP	C	C	T			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	1	34002679	34002679	C	T	SNP	CSMD2	ENST00000373381	human	ensembl	74_37	-1	known	silent	c.9822	p.T3274	0.656	superfamily_Sushi_SCR_CCP,pfscan_Sushi_SCR_CCP	pfam_CUB_dom,pfam_Sushi_SCR_CCP,superfamily_CUB_dom,superfamily_Sushi_SCR_CCP,smart_CUB_dom,smart_Sushi_SCR_CCP,pfscan_CUB_dom,pfscan_Sushi_SCR_CCP	-	no_errors	CSMD2	HGNC	ENSG00000121904	tier1	-	-	84	0	0.00	98	16	14.04	99	0	0.00	114	9	7.32
NF1	0	genome.wustl.edu	37	17	29560033	29560033	+	Missense_Mutation	SNP	C	C	G			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	17	29560033	29560033	C	G	SNP	NF1	ENST00000358273	human	ensembl	74_37	+1	known	missense	c.3510	p.H1170Q	1.000	superfamily_ARM-type_fold	pfam_RasGAP,superfamily_Rho_GTPase_activation_prot,superfamily_ARM-type_fold,superfamily_CRAL-TRIO_dom,smart_RasGAP,smart_CRAL-TRIO_dom,pfscan_CRAL-TRIO_dom,pfscan_RasGAP	-	no_errors	NF1	HGNC	ENSG00000196712	tier1	-	-	82	0	0.00	110	12	9.84	89	0	0.00	89	6	6.32
DLX2	0	genome.wustl.edu	37	2	172966994	172966994	+	Missense_Mutation	SNP	C	C	G			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	2	172966994	172966994	C	G	SNP	DLX2	ENST00000234198	human	ensembl	74_37	-1	known	missense	c.273	p.Q91H	1.000	pfam_Distal-less_N	pfam_Homeobox_dom,pfam_Distal-less_N,superfamily_Homeodomain-like,smart_Homeobox_dom,pfscan_Homeobox_dom,prints_HTH_motif,prints_Homeobox_metazoa	-	no_errors	DLX2	HGNC	ENSG00000115844	tier1	-	-	229	0	0.00	373	41	9.90	64	0	0.00	80	7	8.05
HNF1B	0	genome.wustl.edu	37	17	36104586	36104586	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	17	36104586	36104586	G	A	SNP	HNF1B	ENST00000225893	human	ensembl	74_37	-1	known	missense	c.290	p.A97V	1.000	pfam_HNF-1_N,superfamily_Lambda_D-bd_dom	pfam_HNF1b_C,pfam_HNF-1_N,pfam_Homeobox_dom,superfamily_Lambda_D-bd_dom,superfamily_Homeodomain-like,superfamily_HNF1_dimer_dom,smart_Homeobox_dom,pfscan_Homeobox_dom	-	no_errors	HNF1B	HGNC	ENSG00000108753	tier1	-	-	156	0	0.00	167	19	10.22	5	0	0.00	7	1	12.50
LOR	0	genome.wustl.edu	37	1	153233982	153233984	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	TCT	TCT					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	1	153233982	153233984	TCT	-	DEL	LOR	ENST00000368742	human	ensembl	74_37	+1	known	in_frame_del	c.557_559	p.VC186in_frame_delG	0.000:0.001:0.002	NULL	NULL	-	no_errors	LOR	HGNC	ENSG00000203782	tier1			10	0	0.00	9	4	30.77	1	0	0.00	1	0	0.00
PIPSL	0	genome.wustl.edu	37	10	95718421	95718421	+	R	SNP	C	C	T			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	10	95718421	95718421	C	T	SNP	PIPSL	ENST00000480546	human	ensembl	74_37	-1	putative	rna	NULL	NULL	0.148	-	-	-	no_errors	PIPSL	HGNC	ENSG00000180764	tier1	-	-	32	0	0.00	25	5	16.67	0	0	0.00	0	0	0.00
KIAA1598	0	genome.wustl.edu	37	10	118689409	118689409	+	Silent	SNP	T	T	C			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	10	118689409	118689409	T	C	SNP	KIAA1598	ENST00000392903	human	ensembl	74_37	-1	known	silent	c.963	p.E321	0.630	superfamily_Adenylate_cyclase-assoc_CAP_N	superfamily_Adenylate_cyclase-assoc_CAP_N	-	no_errors	KIAA1598	HGNC	ENSG00000187164	tier1	-	-	189	0	0.00	188	27	12.56	127	0	0.00	63	3	4.55
WNK2	0	genome.wustl.edu	37	9	96030314	96030326	+	Frame_Shift_Del	DEL	TCCCAAGCCAACG	TCCCAAGCCAACG	-			TCGA-DX-A6BG-01A-11D-A307-09	TCGA-DX-A6BG-10A-01D-A307-09	TCCCAAGCCAACG	TCCCAAGCCAACG					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	fecf5edc-7a04-4f9d-a478-20c262780124	e882eeb1-035e-495c-b29b-5fcef3b36cfc	9	96030314	96030326	TCCCAAGCCAACG	-	DEL	WNK2	ENST00000297954	human	ensembl	74_37	+1	known	frame_shift_del	c.3880_3892	p.S1294fs	0.968:1.000:0.997:1.000:0.962:0.188:0.002:0.001:0.000:0.037:0.042:0.034:0.972	NULL	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Kinase_OSR1/WNK_CCT,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	WNK2	HGNC	ENSG00000165238	tier1			68	0	0.00	57	3	5.00	68	0	0.00	57	3	5.00