Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SPNS3	201305	broad.mit.edu	37	17	4337299	4337299	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr17:4337299G>A	uc002fxt.3	+	0	81	c.37G>A	c.(37-39)Ggg>Agg	p.G13R	SPNS3_uc002fxu.3_5'UTR	NM_182538	NP_872344	Q6ZMD2	SPNS3_HUMAN	Homo sapiens spinster homolog 3 (Drosophila) (SPNS3), mRNA.	13					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						CCCTGAGCCTGGGCCAGGAGG	0.677000														14			3		0	0	1	0	0
LOC650368	650368	broad.mit.edu	37	11	3424149	3424149	+	RNA	SNP	C	T	T	rs112841660		TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr11:3424149C>T	uc010qxs.1	+	5		c.518C>T			LOC650368_uc001lxy.2_Non-coding_Transcript					Homo sapiens asparagine-linked glycosylation 1-like pseudogene (LOC650368), non-coding RNA.																		TCATAGAGGACGAAGACTTCT	0.562000														21			3		0	0	1	0	0
MMD2	221938	broad.mit.edu	37	7	4965137	4965137	+	Missense_Mutation	SNP	T	C	C			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr7:4965137T>C	uc003sno.4	-	1	270	c.74A>G	c.(73-75)cAc>cGc	p.H25R	MMD2_uc003snl.1_Non-coding_Transcript|MMD2_uc003snn.4_Missense_Mutation_p.H25R|MMD2_uc010ksq.3_Missense_Mutation_p.H25R	NM_001100600	NP_001094070	Q8IY49	PAQRA_HUMAN	Homo sapiens monocyte to macrophage differentiation-associated 2 (MMD2), transcript variant 1, mRNA.	25						integral to membrane	receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(11)	14		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.097)|OV - Ovarian serous cystadenocarcinoma(56;3.4e-14)		GTACCTCTTGTGGGCAGGGAC	0.582000														70			25		0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47746247	47746247	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr1:47746247G>A	uc001crd.1	-	11	2038	c.1883C>T	c.(1882-1884)tCc>tTc	p.S628F	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.S581F|STIL_uc010omo.1_Missense_Mutation_p.S628F|STIL_uc001crc.1_Missense_Mutation_p.S628F|STIL_uc001cre.1_Missense_Mutation_p.S628F|STIL_uc001crf.1_Missense_Mutation_p.S241F|STIL_uc001crg.1_Missense_Mutation_p.S581F	NM_001048166	NP_001041631	Q15468	STIL_HUMAN	Homo sapiens SCL/TAL1 interrupting locus (STIL), transcript variant 1, mRNA.	628	PIN1-binding (By similarity).				cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				ATCTTGAATGGATCCAACTGT	0.418000														141			47		0	0	1	0	0
PFKM	5213	broad.mit.edu	37	12	48536634	48536634	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr12:48536634G>A	uc001rrb.2	+	19	2210	c.1936G>A	c.(1936-1938)Ggc>Agc	p.G646S	PFKM_uc001rra.2_Missense_Mutation_p.G260S|PFKM_uc001rrc.3_Missense_Mutation_p.G575S|PFKM_uc001rrd.3_Missense_Mutation_p.G260S|PFKM_uc001rre.2_Missense_Mutation_p.G575S|PFKM_uc021qxj.1_Missense_Mutation_p.G575S|PFKM_uc001rrg.2_Missense_Mutation_p.G544S	NM_001166686	NP_001160160	P08237	K6PF_HUMAN	Homo sapiens phosphofructokinase, muscle (PFKM), transcript variant 1, mRNA.	575					fructose 6-phosphate metabolic process|glycolysis|muscle cell homeostasis	6-phosphofructokinase complex|apical plasma membrane	6-phosphofructokinase activity|ATP binding|identical protein binding|kinase binding|metal ion binding|protein C-terminus binding			NS(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						GACTATGGGTGGCTACTGTGG	0.542000														53			21		0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167245760	167245760	+	Missense_Mutation	SNP	T	C	C			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr3:167245760T>C	uc003fev.1	-	10	1700	c.1396A>G	c.(1396-1398)Act>Gct	p.T466A	WDR49_uc003feu.1_Missense_Mutation_p.T291A|WDR49_uc011bpd.1_Intron|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	Homo sapiens WD repeat domain 49 (WDR49), mRNA.	466										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						CTTATCAGAGTTGGGGCCTTG	0.393000														39			16		0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41385035	41385035	+	Missense_Mutation	SNP	G	T	T			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr21:41385035G>T	uc002yyq.1	-	32	6417	c.5965C>A	c.(5965-5967)Caa>Aaa	p.Q1989K	DSCAM_uc002yyr.1_Non-coding_Transcript	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Homo sapiens Down syndrome cell adhesion molecule (DSCAM), transcript variant 1, mRNA.	1989				HRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQK SRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQR EGAELGQAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV -> IGQVTSYICLHTLEWTFC (in Ref. 1; AAC17966).	cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding	p.S1988F(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGTGATTCTTGGGAGCTGCTC	0.562000														28			9		2.17888e-05	2.32914e-05	1	1	0
AK302694	0	broad.mit.edu	37	10	30993404	30993404	+	Silent	SNP	G	A	A	rs11008192	by1000genomes	TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr10:30993404G>A	uc010qdx.1	+	6	1100	c.558G>A	c.(556-558)acG>acA	p.T186T						SubName: Full=cDNA FLJ59642, highly similar to Supervillin;																		TGCCCCAGACGACAGCAGGTG	0.577000														27			3		0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57602232	57602232	+	Missense_Mutation	SNP	A	G	G			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr1:57602232A>G	uc009vzx.1	-	3	610	c.290T>C	c.(289-291)tTt>tCt	p.F97S	DAB1_uc001cyt.1_Missense_Mutation_p.F97S|DAB1_uc001cyq.1_Missense_Mutation_p.F97S|DAB1_uc001cyr.1_Missense_Mutation_p.F97S|DAB1_uc009vzw.1_Missense_Mutation_p.F97S|DAB1_uc001cys.1_Missense_Mutation_p.F97S	NM_021080	NP_066566	O75553	DAB1_HUMAN	Homo sapiens disabled homolog 1 (Drosophila) (DAB1), mRNA.	97	PID.				cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						CTTCTCATCAAAGATTTTGAT	0.413000														26			3		0	0	1	0	0
PRB2	653247	broad.mit.edu	37	12	11546389	11546389	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr12:11546389C>T	uc010shk.1	-	2	658	c.623G>A	c.(622-624)gGa>gAa	p.G208E		NM_006248	NP_006239			Homo sapiens proline-rich protein BstNI subfamily 2 (PRB2), mRNA.											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTTGTTGCCTCCTTGTGGGGG	0.602000														141			45		0	0	1	0	0
KLC2	64837	broad.mit.edu	37	11	66032657	66032657	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr11:66032657G>A	uc010rov.1	+	10	1528	c.1285G>A	c.(1285-1287)Gcc>Acc	p.A429T	KLC2_uc010row.1_Missense_Mutation_p.A429T|KLC2_uc001ohb.2_Missense_Mutation_p.A429T|KLC2_uc010rox.1_Missense_Mutation_p.A352T|KLC2_uc001ohc.2_Missense_Mutation_p.A429T|KLC2_uc001ohd.2_Missense_Mutation_p.A352T|KLC2_uc001ohe.1_Missense_Mutation_p.A290T	NM_001134775	NP_073733	Q9H0B6	KLC2_HUMAN	Homo sapiens kinesin light chain 2 (KLC2), transcript variant 3, mRNA.	429					blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	24						CCGGGACAGCGCCCCCTATGG	0.657000											OREG0021098	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		56			5		0	0	1	0	0
LRRC43	254050	broad.mit.edu	37	12	122674691	122674691	+	Missense_Mutation	SNP	C	A	A			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr12:122674691C>A	uc009zxm.3	+	4	702	c.677C>A	c.(676-678)tCc>tAc	p.S226Y	LRRC43_uc001ubw.4_Missense_Mutation_p.S41Y|LRRC43_uc009zxn.3_5'UTR	NM_001098519	NP_689972	Q8N309	LRC43_HUMAN	Homo sapiens leucine rich repeat containing 43 (LRRC43), transcript variant 1, mRNA.	226										NS(1)|endometrium(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(2)	19	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		AACCTCGTCTCCCTGGACCTG	0.647000														87			31		1.08312e-15	1.19917e-15	1	1	0
HDAC7	51564	broad.mit.edu	37	12	48177641	48177641	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr12:48177641C>T	uc010slo.2	-	25	3154	c.2959G>A	c.(2959-2961)Gaa>Aaa	p.E987K	HDAC7_uc001rqe.3_Missense_Mutation_p.E421K|HDAC7_uc001rqj.4_Missense_Mutation_p.E950K|HDAC7_uc001rqk.4_Missense_Mutation_p.E970K	NM_015401	NP_056216	Q8WUI4	HDAC7_HUMAN	Homo sapiens histone deacetylase 7 (HDAC7), transcript variant 1, mRNA.	948					negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|protein kinase C binding|repressing transcription factor binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25				GBM - Glioblastoma multiforme(48;0.137)		TTCATAGGTTCTTCCTCCTCC	0.602000														5			3		0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152521048	152521048	+	Missense_Mutation	SNP	C	A	A			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr2:152521048C>A	uc021vrb.1	-	41	5447	c.5418G>T	c.(5416-5418)aaG>aaT	p.K1806N	NEB_uc002txu.3_Missense_Mutation_p.K1806N|NEB_uc021vrc.1_Missense_Mutation_p.K1806N|NEB_uc010fnx.3_Missense_Mutation_p.K1806N|NEB_uc021vrd.1_Missense_Mutation_p.K1806N	NM_004543	NP_004534	P20929	NEBU_HUMAN	Homo sapiens nebulin (NEB), transcript variant 3, mRNA.	1806					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	Z disc|actin cytoskeleton|cytosol	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTCTTGCAGCCTTTATTGCAA	0.428000														5			5		0.000602214	0.000602214	1	1	0
C20orf72	92667	broad.mit.edu	37	20	17950555	17950555	+	Missense_Mutation	SNP	T	G	G			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr20:17950555T>G	uc002wqh.3	+	1	135	c.53T>G	c.(52-54)tTt>tGt	p.F18C	C20orf72_uc010gco.3_Non-coding_Transcript|C20orf72_uc010gcp.3_5'Flank|SNX5_uc002wqc.3_5'Flank|SNX5_uc002wqd.3_5'Flank|SNX5_uc002wqe.3_5'Flank|SNX5_uc010zrt.1_5'Flank|AK296947_uc021way.1_5'Flank	NM_052865	NP_443097	Q9BQP7	CT072_HUMAN	Homo sapiens chromosome 20 open reading frame 72 (C20orf72), mRNA.	18										breast(1)|large_intestine(2)|lung(2)|urinary_tract(2)	7						AGTTCAAAGTTTTCTGTGGAA	0.413000														70			15		0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92472755	92472755	+	Missense_Mutation	SNP	T	A	A			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr14:92472755T>A	uc001xzy.3	-	10	1939	c.1565A>T	c.(1564-1566)cAa>cTa	p.Q522L	TRIP11_uc010auf.2_Missense_Mutation_p.Q258L	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	Homo sapiens thyroid hormone receptor interactor 11 (TRIP11), mRNA.	522					transcription from RNA polymerase II promoter	Golgi apparatus|cytoskeleton|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		TCCTTCATTTTGTTGTTTTGA	0.289000			T	PDGFRB	AML									28			15		0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T	rs121913377		TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome					44			22		0	0	1	0	0
CCDC99	54908	broad.mit.edu	37	5	169021224	169021224	+	Missense_Mutation	SNP	C	T	T			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr5:169021224C>T	uc003mae.4	+	4	886	c.607C>T	c.(607-609)Cgc>Tgc	p.R203C	CCDC99_uc010jjj.3_Missense_Mutation_p.R132C|CCDC99_uc011deq.2_Missense_Mutation_p.R20C|CCDC99_uc010jjk.3_Intron	NM_017785	NP_060255	Q96EA4	SPDLY_HUMAN	Homo sapiens coiled-coil domain containing 99 (CCDC99), mRNA.	203					cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(8)|ovary(1)|skin(1)	25	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TAACCTAATGCGCCAGGTAGA	0.388000														46			7		0	0	1	0	0
PDK4	5166	broad.mit.edu	37	7	95216419	95216419	+	Missense_Mutation	SNP	C	G	G			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr7:95216419C>G	uc003uoa.3	-	9	1318	c.998G>C	c.(997-999)gGc>gCc	p.G333A	PDK4_uc003unz.3_Missense_Mutation_p.G121A	NM_002612	NP_002603	Q16654	PDK4_HUMAN	Homo sapiens pyruvate dehydrogenase kinase, isozyme 4 (PDK4), nuclear gene encoding mitochondrial protein, mRNA.	333	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15	all_cancers(62;1.06e-10)|all_epithelial(64;1.04e-09)|Lung NSC(181;0.128)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0151)			AATTGGCAAGCCGTAACCAAA	0.388000														8			16		0	0	1	0	0
X97876	0	broad.mit.edu	37	9	66499716	66499716	+	Missense_Mutation	SNP	A	G	G	rs141617852	by1000genomes	TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr9:66499716A>G	uc004aee.1	+	0	526	c.526A>G	c.(526-528)Aat>Gat	p.N176D	X97876_uc004aed.1_Non-coding_Transcript					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).																		CCTGGAGCCCAATCTGCTGGA	0.607000														38			8		0	0	1	0	0
GABRB2	2561	broad.mit.edu	37	5	160761893	160761893	+	Missense_Mutation	SNP	G	A	A			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr5:160761893G>A	uc003lys.1	-	7	916	c.698C>T	c.(697-699)tCc>tTc	p.S233F	GABRB2_uc011deh.1_Missense_Mutation_p.S72F|GABRB2_uc003lyr.1_Missense_Mutation_p.S233F|GABRB2_uc003lyt.1_Missense_Mutation_p.S233F|GABRB2_uc021yhg.1_Missense_Mutation_p.S170F	NM_021911	NP_068711	P47870	GBRB2_HUMAN	Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 2 (GABRB2), transcript variant 1, mRNA.	233					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	GABA-A receptor activity|chloride channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AAAGCTGAGGGATAACCTGGG	0.378000														45			9		0	0	1	0	0
VPRBP	9730	broad.mit.edu	37	3	51456246	51456246	+	Silent	SNP	G	A	A			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr3:51456246G>A	uc003dbe.2	-	14	3347	c.3162C>T	c.(3160-3162)ttC>ttT	p.F1054F	VPRBP_uc021wys.1_Silent_p.F1053F|VPRBP_uc003dbf.1_Silent_p.F383F	NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	Homo sapiens Vpr (HIV-1) binding protein (VPRBP), transcript variant 1, mRNA.	1107					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		CAAGCATCAGGAACCGCTCCC	0.498000														34			18		0	0	1	0	0
PORCN	64840	broad.mit.edu	37	X	48372982	48372982	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chrX:48372982G>A	uc010nie.1	+	9	1073	c.915G>A	c.(913-915)tgG>tgA	p.W305*	PORCN_uc004djr.1_Nonsense_Mutation_p.W300*|PORCN_uc004djs.1_Nonsense_Mutation_p.W294*|PORCN_uc011mlx.1_Nonsense_Mutation_p.W223*|PORCN_uc004dju.1_Nonsense_Mutation_p.W163*|PORCN_uc004djv.1_Nonsense_Mutation_p.W305*|PORCN_uc004djw.1_Nonsense_Mutation_p.W299*	NM_203475	NP_982301	Q9H237	PORCN_HUMAN	Homo sapiens porcupine homolog (Drosophila) (PORCN), transcript variant D, mRNA.	305					Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TCACAAGCTGGAACCTGCCCA	0.483000														41			20		0	0	1	0	0
COIL	8161	broad.mit.edu	37	17	55028117	55028118	+	Frame_Shift_Ins	INS	-	T	T			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chr17:55028117_55028118insT	uc002iuu.3	-	1	516_517	c.485_486insA	c.(484-486)aacfs	p.N162fs		NM_004645	NP_004636	P38432	COIL_HUMAN	Homo sapiens coilin (COIL), mRNA.	162						Cajal body|nucleolus	protein C-terminus binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	15	Breast(9;6.15e-08)					TTTTTCTCTTGTTTTTTTTGCT	0.366													---	167	---	---	7	---					
PCDH19	57526	broad.mit.edu	37	X	99663560	99663562	+	In_Frame_Del	DEL	CAG	-	-			TCGA-EB-A3XE-01A-12D-A23B-08	TCGA-EB-A3XE-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5cf76c0-b02b-4d85-a73d-fa18ff2b0eac	6e985c20-0123-4be3-9c88-2301cb76f604	g.chrX:99663560_99663562delCAG	uc010nmz.3	-	0	1710_1712	c.34_36delCTG	c.(34-36)ctgdel	p.L12del	PCDH19_uc004efw.4_In_Frame_Del_p.L12del|PCDH19_uc004efx.4_In_Frame_Del_p.L12del	NM_001184880	NP_001171809	Q8TAB3	PCD19_HUMAN	Homo sapiens protocadherin 19 (PCDH19), transcript variant 3, mRNA.	12					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						ACAGTATGGCCAGCAGCAGCAGC	0.665													---	5	---	---	3	---