Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZBED2	79413	broad.mit.edu	37	3	111312476	111312476	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:111312476C>T	ENST00000317012.4	-	2	1581	c.573G>A	c.(571-573)atG>atA	p.M191I	CD96_ENST00000352690.4_Intron|CD96_ENST00000438817.2_Intron|CD96_ENST00000283285.5_Intron	NM_024508.4	NP_078784.2	Q9BTP6	ZBED2_HUMAN	zinc finger, BED-type containing 2	191							DNA binding|metal ion binding			large_intestine(3)|lung(1)|skin(2)	6						CCTTCCACTTCATCTCCAGGA	0.557000													7	56					0	0	0.000157383	0	0
EPSTI1	94240	broad.mit.edu	37	13	43462503	43462503	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr13:43462503G>A	ENST00000313640.7	-	13	1180	c.1116C>T	c.(1114-1116)gaC>gaT	p.D372D	EPSTI1_ENST00000313624.7_3'UTR	NM_001002264.2	NP_001002264.1	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 (breast)	0										endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|skin(1)	17		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)		TGACTGCACGGTCAAGTGTGT	0.428000													15	41					0	0	0.000308642	0	0
TAAR9	134860	broad.mit.edu	37	6	132859650	132859650	+	RNA	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:132859650G>A	ENST00000434551.1	+	0	222					NM_175057.3	NP_778227.3	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9 (gene/pseudogene)							plasma membrane	G-protein coupled receptor activity					Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		TTGCGTCGCTGGCCTGTGCTG	0.498000													7	73					0	0	0.000157383	0	0
DNAH3	55567	broad.mit.edu	37	16	20975459	20975459	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr16:20975459G>A	ENST00000261383.3	-	53	9746	c.9747C>T	c.(9745-9747)tcC>tcT	p.S3249S	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3249	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TGTTACCCTTGGACATGGAGA	0.433000													25	133					0	0	0.000586117	0	0
ZNF831	128611	broad.mit.edu	37	20	57829603	57829603	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr20:57829603G>A	ENST00000371030.2	+	5	4839	c.4839G>A	c.(4837-4839)agG>agA	p.R1613R		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1613						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GTGACGGTAGGAAACGTCAGG	0.493000													7	65					0	0	8.12818e-05	0	0
C1QTNF9B	387911	broad.mit.edu	37	13	24470978	24470978	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr13:24470978C>T	ENST00000382137.3	-	1	216	c.148G>A	c.(148-150)Ggt>Agt	p.G50S	C1QTNF9B_ENST00000556521.1_5'UTR|C1QTNF9B-AS1_ENST00000417034.1_RNA|C1QTNF9B_ENST00000382140.2_Missense_Mutation_p.G50S|C1QTNF9B_ENST00000382145.1_Missense_Mutation_p.G50S|C1QTNF9B_ENST00000382057.3_Missense_Mutation_p.G50S	NM_001007537.1	NP_001007538.1	B2RNN3	C1T9B_HUMAN	C1q and tumor necrosis factor related protein 9B	50	Collagen-like 1.					collagen				breast(1)|central_nervous_system(1)|large_intestine(3)|lung(1)	6						CCTTTGTCACCCTTCGCTCCG	0.532000													5	28					0	0	0.000274275	0	0
FAT3	120114	broad.mit.edu	37	11	92592355	92592355	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:92592355G>A	ENST00000298047.6	+	20	11542	c.11525G>A	c.(11524-11526)gGa>gAa	p.G3842E	FAT3_ENST00000409404.2_Missense_Mutation_p.G3842E|FAT3_ENST00000525166.1_Missense_Mutation_p.G3692E|FAT3_ENST00000533797.1_Missense_Mutation_p.G177E			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3842	Laminin G-like.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGCTTTGCTGGAAACAGTTAC	0.388000										TCGA Ovarian(4;0.039)			47	277					0	0	0.000781405	0	0
CPEB2	132864	broad.mit.edu	37	4	15009173	15009173	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:15009173G>A	ENST00000538197.1	+	2	1907	c.1907G>A	c.(1906-1908)aGa>aAa	p.R636K	CPEB2_ENST00000507071.1_Missense_Mutation_p.R199K|CPEB2_ENST00000259997.5_Missense_Mutation_p.R199K|CPEB2_ENST00000541112.1_Missense_Mutation_p.R636K|RP11-665G4.1_ENST00000513384.1_RNA|CPEB2_ENST00000442003.2_Missense_Mutation_p.R636K|RP11-665G4.1_ENST00000502344.1_RNA|CPEB2_ENST00000382401.3_Missense_Mutation_p.R199K|CPEB2_ENST00000382395.3_Missense_Mutation_p.R199K|CPEB2_ENST00000345451.3_Missense_Mutation_p.R199K	NM_001177382.1	NP_001170853.1	Q7Z5Q1	CPEB2_HUMAN	cytoplasmic polyadenylation element binding protein 2	199					regulation of translation	cytoplasm	nucleotide binding|RNA binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|skin(3)	14						AATGTGTTCAGAACAGACAAC	0.368000													7	49					0	0	8.12818e-05	0	0
GRM8	2918	broad.mit.edu	37	7	126410017	126410017	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:126410017T>C	ENST00000339582.2	-	7	2067	c.1259A>G	c.(1258-1260)cAc>cGc	p.H420R	GRM8_ENST00000444921.2_Missense_Mutation_p.H420R|GRM8_ENST00000405249.1_Missense_Mutation_p.H420R|GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000358373.3_Missense_Mutation_p.H420R			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	420					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GAGATCTTTGTGCATATTGTG	0.428000										HNSCC(24;0.065)			5	41					0	0	0.00116845	0	0
CER1	9350	broad.mit.edu	37	9	14720113	14720113	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr9:14720113G>A	ENST00000380911.3	-	2	823	c.779C>T	c.(778-780)tCc>tTc	p.S260F		NM_005454.2	NP_005445.1	O95813	CER1_HUMAN	cerberus 1, DAN family BMP antagonist	260					BMP signaling pathway	extracellular space	cytokine activity			endometrium(2)|large_intestine(3)|lung(6)	11				GBM - Glioblastoma multiforme(50;3.16e-06)		TGGGATAAAGGAATCCTGGGA	0.468000													9	47					0	0	0.000673444	0	0
EPHA10	284656	broad.mit.edu	37	1	38227053	38227053	+	Missense_Mutation	SNP	C	C	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:38227053C>A	ENST00000319637.6	-	3	940	c.874G>T	c.(874-876)Ggg>Tgg	p.G292W	EPHA10_ENST00000373048.4_Intron|EPHA10_ENST00000427468.2_Intron	NM_173641.2	NP_775912.2	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	0						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				ACTCCCACCCCACGGCCCCCA	0.652000													12	48					2.32078e-09	1.18692e-08	0.000308642	1	0
OR6C74	254783	broad.mit.edu	37	12	55641806	55641806	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:55641806C>T	ENST00000343870.4	+	1	825	c.735C>T	c.(733-735)gtC>gtT	p.V245V		NM_001005490.1	NP_001005490.1	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C, member 74	245					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	12						ACATGGTGGTCGTGTCCATTT	0.388000													7	98					0	0	0.000157383	0	0
DNAJC5B	85479	broad.mit.edu	37	8	66963846	66963846	+	Missense_Mutation	SNP	G	G	A	rs141686243		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:66963846G>A	ENST00000276570.5	+	3	351	c.64G>A	c.(64-66)Gaa>Aaa	p.E22K	DNAJC5B_ENST00000519330.1_3'UTR	NM_033105.4	NP_149096.2	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	22	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding	p.E22K(2)		endometrium(3)|large_intestine(6)|liver(1)|lung(6)|prostate(1)|skin(3)	20		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			AGCTCTATACGAAATTCTTGG	0.398000													10	72					0	0	0.000442599	0	0
TXNL1	9352	broad.mit.edu	37	18	54293650	54293650	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr18:54293650G>A	ENST00000217515.6	-	2	341	c.137C>T	c.(136-138)tCt>tTt	p.S46F	TXNL1_ENST00000590954.1_Missense_Mutation_p.S46F|TXNL1_ENST00000540155.1_5'UTR	NM_004786.2	NP_004777.1	O43396	TXNL1_HUMAN	thioredoxin-like 1	46	Thioredoxin.				cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity			endometrium(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)		ATTACTCATAGAACTGAATGC	0.348000													20	135					0	0	0.00047179	0	0
NR2E3	10002	broad.mit.edu	37	15	72105937	72105937	+	RNA	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr15:72105937G>A	ENST00000398840.2	+	0	1145							Q9Y5X4	NR2E3_HUMAN	nuclear receptor subfamily 2, group E, member 3						phototransduction|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|endometrium(1)|lung(1)	3						GACCCCCACGGAGTTTGCCTG	0.607000													7	33					0	0	8.12818e-05	0	0
RP1L1	94137	broad.mit.edu	37	8	10465906	10465906	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:10465906G>A	ENST00000382483.3	-	4	5925	c.5702C>T	c.(5701-5703)cCa>cTa	p.P1901L		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1901					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		TTCTGACTCTGGCTGGACCTC	0.597000													9	118					0	0	0.000673444	0	0
ROPN1L	83853	broad.mit.edu	37	5	10461368	10461368	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:10461368C>T	ENST00000503804.1	+	5	1011	c.490C>T	c.(490-492)Ccc>Tcc	p.P164S	ROPN1L_ENST00000510520.1_3'UTR|ROPN1L_ENST00000274134.4_Missense_Mutation_p.P164S			Q96C74	ROP1L_HUMAN	rhophilin associated tail protein 1-like	164					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)	14						CGCTCGCATCCCCTTCAAGAC	0.567000													13	80					0	0	0.00185496	0	0
CELSR3	1951	broad.mit.edu	37	3	48688421	48688421	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:48688421G>A	ENST00000544264.1	-	15	6554	c.6274C>T	c.(6274-6276)Cac>Tac	p.H2092Y	CELSR3_ENST00000164024.4_Missense_Mutation_p.H2092Y			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2092	Laminin EGF-like.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGCCCGCTGTGGGGTGCACAT	0.657000													6	47					0	0	0.00116845	0	0
ST3GAL3	6487	broad.mit.edu	37	1	44360080	44360080	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:44360080C>T	ENST00000262915.3	+	7	712	c.535C>T	c.(535-537)Ctg>Ttg	p.L179L	ST3GAL3_ENST00000372372.2_Silent_p.L148L|ST3GAL3_ENST00000361746.4_Silent_p.L179L|ST3GAL3_ENST00000372374.2_Silent_p.L79L|ST3GAL3_ENST00000372366.1_Silent_p.L109L|ST3GAL3_ENST00000372377.4_Silent_p.L110L|ST3GAL3_ENST00000461375.1_3'UTR|ST3GAL3_ENST00000361812.4_Silent_p.L125L|ST3GAL3_ENST00000372368.2_Silent_p.L164L|ST3GAL3_ENST00000361392.4_Silent_p.L110L|ST3GAL3_ENST00000361400.4_Silent_p.L94L|ST3GAL3_ENST00000372367.1_Silent_p.L109L|ST3GAL3_ENST00000351035.3_Silent_p.L148L|ST3GAL3_ENST00000347631.2_Silent_p.L125L|ST3GAL3_ENST00000533933.1_Silent_p.L110L|ST3GAL3_ENST00000332628.6_Silent_p.L79L|ST3GAL3_ENST00000372362.2_Silent_p.L110L|ST3GAL3_ENST00000330208.2_Silent_p.L110L|ST3GAL3_ENST00000372365.1_Silent_p.L110L|ST3GAL3_ENST00000372375.2_Silent_p.L164L|ST3GAL3_ENST00000545417.1_Silent_p.L125L|ST3GAL3_ENST00000353126.3_Silent_p.L110L|ST3GAL3_ENST00000372369.1_Silent_p.L110L|ST3GAL3_ENST00000335430.6_Silent_p.L94L|ST3GAL3_ENST00000531816.1_Intron|ST3GAL3_ENST00000531993.1_Silent_p.L94L|ST3GAL3_ENST00000531451.1_Silent_p.L94L|ST3GAL3_ENST00000528371.1_Silent_p.L94L	NM_174963.3	NP_777623.2	Q11203	SIAT6_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	110					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(3)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				ACCCATGTTCCTGGATGACTC	0.507000													24	175					0	0	0.00178596	0	0
TMEM255A	55026	broad.mit.edu	37	X	119438286	119438286	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chrX:119438286G>A	ENST00000371369.4	-	2	345	c.119C>T	c.(118-120)tCc>tTc	p.S40F	TMEM255A_ENST00000440464.1_Missense_Mutation_p.S40F|TMEM255A_ENST00000309720.5_Missense_Mutation_p.S40F	NM_001104544.1	NP_001098014.1			transmembrane protein 255A																		AATTAACACGGACACAATAAG	0.443000													12	37					0	0	0.00136819	0	0
ZIM3	114026	broad.mit.edu	37	19	57646475	57646475	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:57646475C>T	ENST00000269834.1	-	5	1615	c.1230G>A	c.(1228-1230)caG>caA	p.Q410Q		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	410					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TATGAGTTTTCTGATGGCTAT	0.383000													15	155					0	0	0.000566183	0	0
TBXAS1	6916	broad.mit.edu	37	7	139636089	139636089	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:139636089C>T	ENST00000263552.6	+	9	974	c.436C>T	c.(436-438)Cct>Tct	p.P146S	TBXAS1_ENST00000425687.1_Missense_Mutation_p.P78S|TBXAS1_ENST00000414508.2_Missense_Mutation_p.P146S|TBXAS1_ENST00000411653.1_Missense_Mutation_p.P145S|TBXAS1_ENST00000448866.1_Missense_Mutation_p.P145S|TBXAS1_ENST00000436047.2_Missense_Mutation_p.P146S|TBXAS1_ENST00000458722.1_Missense_Mutation_p.P145S|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000416849.2_Missense_Mutation_p.P146S|TBXAS1_ENST00000336425.5_Missense_Mutation_p.P145S	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	145					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					TGCTTTCAGTCCTGAAAAGCT	0.483000													27	184					0	0	0.00106085	0	0
ALMS1	7840	broad.mit.edu	37	2	73653612	73653612	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:73653612C>T	ENST00000264448.6	+	6	1380	c.1269C>T	c.(1267-1269)gtC>gtT	p.V423V	ALMS1_ENST00000377715.1_Silent_p.V423V|ALMS1_ENST00000409009.1_Silent_p.V381V	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	423					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						AGTCTGACGTCATTACTCTGG	0.403000													28	228					0	0	0.001512	0	0
KIAA2018	205717	broad.mit.edu	37	3	113375292	113375292	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:113375292G>A	ENST00000316407.4	-	7	5647	c.5237C>T	c.(5236-5238)cCc>cTc	p.P1746L	KIAA2018_ENST00000491165.1_Intron|KIAA2018_ENST00000478658.1_Missense_Mutation_p.P1746L	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1746					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						ATTACTCTGGGGCTGTTGACT	0.428000													15	67					0	0	0.000219431	0	0
PCNXL4	64430	broad.mit.edu	37	14	60591538	60591538	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:60591538C>T	ENST00000406854.1	+	9	3203	c.2649C>T	c.(2647-2649)taC>taT	p.Y883Y	PCNXL4_ENST00000317623.4_Silent_p.Y649Y|PCNXL4_ENST00000535349.1_Silent_p.Y90Y|PCNXL4_ENST00000406949.1_Silent_p.Y649Y|PCNXL4_ENST00000404681.2_Silent_p.Y883Y					pecanex-like 4 (Drosophila)																		TATTAGGATACCCTGCTGTTG	0.413000													18	145					0	0	0.00074312	0	0
TYROBP	7305	broad.mit.edu	37	19	36395500	36395500	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:36395500G>A	ENST00000585901.2	-	5	424	c.406C>T	c.(406-408)Ctc>Ttc	p.L136F	TYROBP_ENST00000544690.2_Missense_Mutation_p.L94F|TYROBP_ENST00000424586.3_Missense_Mutation_p.L93F|TYROBP_ENST00000262629.4_Missense_Mutation_p.L105F|TYROBP_ENST00000589517.1_Missense_Mutation_p.L104F			O43914	TYOBP_HUMAN	TYRO protein tyrosine kinase binding protein	105					axon guidance|cell junction assembly|cellular defense response|intracellular signal transduction|regulation of immune response	integral to plasma membrane|intracellular	identical protein binding|receptor signaling protein activity			NS(1)|central_nervous_system(1)|large_intestine(1)|lung(4)|skin(1)	8	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGTGTGTTGAGGTCGCTGTAG	0.532000													5	27					0	0	8.12818e-05	0	0
BRINP3	339479	broad.mit.edu	37	1	190067958	190067958	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:190067958C>T	ENST00000367462.3	-	8	1722	c.1491G>A	c.(1489-1491)atG>atA	p.M497I	FAM5C_ENST00000534846.1_Missense_Mutation_p.M395I|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		497						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GCAGATATTTCATCTCGAGAT	0.498000													17	139					0	0	0.00121646	0	0
OR2A2	442361	broad.mit.edu	37	7	143807353	143807353	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:143807353G>A	ENST00000408979.2	+	1	747	c.678G>A	c.(676-678)aaG>aaA	p.K226K		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					CCATCCTGAAGATCCAGACAA	0.507000													11	83					0	0	0.000673444	0	0
OR5AK2	390181	broad.mit.edu	37	11	56756415	56756415	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:56756415C>T	ENST00000326855.2	+	1	69	c.27C>T	c.(25-27)gtC>gtT	p.V9V		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						GCACTGAAGTCACTGAATTCT	0.403000													24	136					0	0	0.000720815	0	0
PCDH18	54510	broad.mit.edu	37	4	138452705	138452705	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:138452705C>T	ENST00000344876.4	-	1	924	c.538G>A	c.(538-540)Gat>Aat	p.D180N	PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000412923.2_Missense_Mutation_p.D180N|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000507846.1_5'UTR	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	180	Cadherin 2.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TTAAAAAAATCATTGGCAGAG	0.483000													9	54					0	0	0.000274275	0	0
PLA2G5	5322	broad.mit.edu	37	1	20417110	20417110	+	Silent	SNP	C	C	T	rs144012929		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:20417110C>T	ENST00000375108.3	+	5	610	c.342C>T	c.(340-342)ctC>ctT	p.L114L	PLA2G5_ENST00000486277.1_3'UTR	NM_000929.2	NP_000920.1	P39877	PA2G5_HUMAN	phospholipase A2, group V	114					lipid catabolic process	extracellular region	calcium ion binding|calcium-dependent phospholipase A2 activity	p.L114L(1)		NS(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000249)|Lung NSC(340;0.000287)|Breast(348;0.000812)|Ovarian(437;0.00328)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;8.15e-05)|Kidney(64;0.000184)|GBM - Glioblastoma multiforme(114;0.00089)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0652)		ACCGGAAGCTCGTCTACTGCC	0.567000													7	78					0	0	8.12818e-05	0	0
ZNF585B	92285	broad.mit.edu	37	19	37677377	37677377	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:37677377G>A	ENST00000532828.2	-	5	1313	c.1062C>T	c.(1060-1062)tcC>tcT	p.S354S	ZNF585B_ENST00000312908.5_5'UTR|ZNF585B_ENST00000531805.1_Silent_p.S299S|CTC-454I21.3_ENST00000585860.2_Intron|ZNF585B_ENST00000527838.1_3'UTR	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	354					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAGTACATATGGAAGATTTCT	0.403000													12	105					0	0	0.00136819	0	0
PHLDB1	23187	broad.mit.edu	37	11	118498078	118498078	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:118498078C>T	ENST00000361417.2	+	7	950	c.539C>T	c.(538-540)cCc>cTc	p.P180L	PHLDB1_ENST00000356063.5_Missense_Mutation_p.P180L	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	180										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		ACACGGGGACCCTCTGCCTGT	0.542000													8	42					0	0	0.000274275	0	0
ZNFX1	57169	broad.mit.edu	37	20	47870326	47870326	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr20:47870326G>A	ENST00000396105.1	-	11	3228	c.2982C>T	c.(2980-2982)atC>atT	p.I994I	ZNFX1_ENST00000371754.4_Silent_p.I994I|ZNFX1_ENST00000371752.1_Silent_p.I994I	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	994							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CCTTCTGTAGGATCTGGCGGT	0.557000													14	194					0	0	0.00152264	0	0
KLKB1	3818	broad.mit.edu	37	4	187178420	187178420	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:187178420G>T	ENST00000264690.6	+	14	1813	c.1626G>T	c.(1624-1626)ttG>ttT	p.L542F	KLKB1_ENST00000513864.1_Intron	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	542	Peptidase S1.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		ATATTCCTTTGGTAACAAATG	0.318000													6	125					3.59834e-05	0.000182984	0.00116845	1	0
HIST2H2BA	337875	broad.mit.edu	37	1	120906358	120906358	+	RNA	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:120906358G>A	ENST00000430394.1	+	0	331					NR_027337.1																						GCTGCCCGGCGAGCTGGCCAA	0.637000													6	29					0	0	8.12818e-05	0	0
MST1R	4486	broad.mit.edu	37	3	49940718	49940718	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:49940718G>A	ENST00000296474.3	-	1	352	c.325C>T	c.(325-327)Cca>Tca	p.P109S	CTD-2330K9.2_ENST00000435478.1_RNA|MST1R_ENST00000344206.4_Missense_Mutation_p.P109S	NM_002447.2	NP_002438.2	Q04912	RON_HUMAN	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	109	Sema.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			cervix(1)|endometrium(5)|large_intestine(3)|lung(17)|ovary(5)|prostate(2)|skin(1)|urinary_tract(3)	37				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TGGGGTCCTGGGCCACAGGCT	0.677000													7	43					0	0	8.12818e-05	0	0
SREBF2	6721	broad.mit.edu	37	22	42271552	42271552	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr22:42271552C>T	ENST00000361204.4	+	7	1376	c.1210C>T	c.(1210-1212)Cta>Tta	p.L404L		NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	404	Interaction with LMNA (By similarity).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						TGCAGAGCTTCTAAAGGGCAT	0.507000													30	160					0	0	0.000339439	0	0
GPR152	390212	broad.mit.edu	37	11	67219361	67219361	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:67219361A>G	ENST00000312457.2	-	1	839	c.835T>C	c.(835-837)Tac>Cac	p.Y279H		NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	279						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			TAGTCGGAGTAGACCAGGGCC	0.637000													9	46					0	0	0.000274275	0	0
BRD8	10902	broad.mit.edu	37	5	137501622	137501622	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:137501622C>T	ENST00000254900.5	-	11	1544	c.1173G>A	c.(1171-1173)aaG>aaA	p.K391K	BRD8_ENST00000455658.2_Silent_p.K350K|BRD8_ENST00000402931.1_Silent_p.K391K|BRD8_ENST00000411594.2_Silent_p.K394K|BRD8_ENST00000230901.5_Silent_p.K464K	NM_139199.1	NP_631938.1	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	391					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CTAATTCTTCCTTCCCATCTA	0.438000													8	72					0	0	0.000157383	0	0
ADAP2	55803	broad.mit.edu	37	17	29276364	29276364	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:29276364C>T	ENST00000330889.3	+	7	1052	c.717C>T	c.(715-717)gcC>gcT	p.A239A	ADAP2_ENST00000580525.1_Silent_p.A245A	NM_018404.2	NP_060874.1	Q9NPF8	ADAP2_HUMAN	ArfGAP with dual PH domains 2	239					heart development|regulation of ARF GTPase activity	mitochondrial envelope|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|zinc ion binding	p.?(1)		breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						TAAAAATGGCCTTTCCTGAAC	0.527000													5	71					0	0	0.00116845	0	0
VWA8	23078	broad.mit.edu	37	13	42142384	42142384	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr13:42142384G>A	ENST00000379310.3	-	45	5735	c.5667C>T	c.(5665-5667)atC>atT	p.I1889I		NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		AAATCTGAGGGATATCCTTGG	0.468000													11	75					0	0	0.000673444	0	0
ZNF804B	219578	broad.mit.edu	37	7	88956692	88956692	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:88956692G>A	ENST00000333190.4	+	3	893	c.284G>A	c.(283-285)cGa>cAa	p.R95Q		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	95						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GAATTTGCTCGAAATGTAGCT	0.338000										HNSCC(36;0.09)			9	40					0	0	0.000274275	0	0
TTN	7273	broad.mit.edu	37	2	179654155	179654155	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:179654155C>T	ENST00000589042.1	-	13	2232	c.2008G>A	c.(2008-2010)Gaa>Aaa	p.E670K	TTN_ENST00000460472.2_Missense_Mutation_p.E624K|TTN_ENST00000342175.6_Missense_Mutation_p.E624K|TTN_ENST00000591111.1_Missense_Mutation_p.E670K|TTN_ENST00000359218.5_Missense_Mutation_p.E624K|TTN_ENST00000360870.5_Missense_Mutation_p.E670K|TTN_ENST00000342992.6_Missense_Mutation_p.E670K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	670							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTATTGTTTCTTGTTCTTTG	0.378000													10	82					0	0	0.000442599	0	0
ST3GAL3	6487	broad.mit.edu	37	1	44360079	44360079	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:44360079C>T	ENST00000262915.3	+	7	711	c.534C>T	c.(532-534)ttC>ttT	p.F178F	ST3GAL3_ENST00000372372.2_Silent_p.F147F|ST3GAL3_ENST00000361746.4_Silent_p.F178F|ST3GAL3_ENST00000372374.2_Silent_p.F78F|ST3GAL3_ENST00000372366.1_Silent_p.F108F|ST3GAL3_ENST00000372377.4_Silent_p.F109F|ST3GAL3_ENST00000461375.1_3'UTR|ST3GAL3_ENST00000361812.4_Silent_p.F124F|ST3GAL3_ENST00000372368.2_Silent_p.F163F|ST3GAL3_ENST00000361392.4_Silent_p.F109F|ST3GAL3_ENST00000361400.4_Silent_p.F93F|ST3GAL3_ENST00000372367.1_Silent_p.F108F|ST3GAL3_ENST00000351035.3_Silent_p.F147F|ST3GAL3_ENST00000347631.2_Silent_p.F124F|ST3GAL3_ENST00000533933.1_Silent_p.F109F|ST3GAL3_ENST00000332628.6_Silent_p.F78F|ST3GAL3_ENST00000372362.2_Silent_p.F109F|ST3GAL3_ENST00000330208.2_Silent_p.F109F|ST3GAL3_ENST00000372365.1_Silent_p.F109F|ST3GAL3_ENST00000372375.2_Silent_p.F163F|ST3GAL3_ENST00000545417.1_Silent_p.F124F|ST3GAL3_ENST00000353126.3_Silent_p.F109F|ST3GAL3_ENST00000372369.1_Silent_p.F109F|ST3GAL3_ENST00000335430.6_Silent_p.F93F|ST3GAL3_ENST00000531816.1_Intron|ST3GAL3_ENST00000531993.1_Silent_p.F93F|ST3GAL3_ENST00000531451.1_Silent_p.F93F|ST3GAL3_ENST00000528371.1_Silent_p.F93F	NM_174963.3	NP_777623.2	Q11203	SIAT6_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	109					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(3)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				CACCCATGTTCCTGGATGACT	0.507000													24	175					0	0	0.00178596	0	0
CEP164	22897	broad.mit.edu	37	11	117261579	117261579	+	Missense_Mutation	SNP	G	G	A	rs142184414	byFrequency	TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:117261579G>A	ENST00000278935.3	+	16	2168	c.2021G>A	c.(2020-2022)cGa>cAa	p.R674Q	CEP164_ENST00000533706.1_3'UTR	NM_014956.4	NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	674	Glu-rich.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		TCCTGGCTCCGAGCTCAGGTC	0.597000													7	54					0	0	8.12818e-05	0	0
FCF1	51077	broad.mit.edu	37	14	75200829	75200829	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:75200829C>T	ENST00000341162.4	+	7	558	c.504C>T	c.(502-504)atC>atT	p.I168I	FCF1_ENST00000553615.1_Silent_p.I153I|FCF1_ENST00000534938.2_Silent_p.I156I	NM_015962.4	NP_057046.1	Q9Y324	FCF1_HUMAN	FCF1 rRNA-processing protein	168					rRNA processing	nucleolus				breast(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(234;0.0037)		AAAGAAGAATCCGTAAGATTC	0.398000													5	47					0	0	0.000602214	0	0
STRC	161497	broad.mit.edu	37	15	43893725	43893725	+	Missense_Mutation	SNP	G	G	A	rs147990592		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr15:43893725G>A	ENST00000450892.2	-	24	4647	c.4570C>T	c.(4570-4572)Cgt>Tgt	p.R1524C	STRC_ENST00000541030.1_Missense_Mutation_p.R751C	NM_153700.2	NP_714544.1	Q7RTU9	STRC_HUMAN	stereocilin	1524					sensory perception of sound	cell surface		p.R1524G(1)		skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		TGCTCAGGACGAAATCCCCGG	0.532000													7	26					0	0	0.000274275	0	0
RTN1	6252	broad.mit.edu	37	14	60074019	60074019	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:60074019C>T	ENST00000267484.5	-	4	2292	c.1957G>A	c.(1957-1959)Gaa>Aaa	p.E653K	RTN1_ENST00000342503.4_Missense_Mutation_p.E85K|RTN1_ENST00000395090.1_Missense_Mutation_p.E70K|RTN1_ENST00000557422.1_5'UTR	NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	653	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		GGGTGGCCTTCGTCGGTTTTC	0.562000													5	23					0	0	0.00116845	0	0
PTPN21	11099	broad.mit.edu	37	14	88962767	88962767	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:88962767G>A	ENST00000556564.1	-	10	1206	c.922C>T	c.(922-924)Cag>Tag	p.Q308*	PTPN21_ENST00000554628.1_5'UTR|PTPN21_ENST00000328736.3_Nonsense_Mutation_p.Q308*	NM_007039.3	NP_008970.2	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type 21	308	FERM.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|liver(1)|lung(7)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						AGGTTACACTGGTTTAGTCTG	0.333000													10	68					0	0	0.000673444	0	0
NOSTRIN	115677	broad.mit.edu	37	2	169684702	169684702	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:169684702G>A	ENST00000444448.2	+	6	708	c.232G>A	c.(232-234)Gga>Aga	p.G78R	NOSTRIN_ENST00000397209.2_Missense_Mutation_p.G50R|NOSTRIN_ENST00000317647.7_Missense_Mutation_p.G78R|NOSTRIN_ENST00000421711.2_Missense_Mutation_p.G50R|NOSTRIN_ENST00000397206.2_5'UTR|NOSTRIN_ENST00000445023.2_5'UTR|NOSTRIN_ENST00000458381.2_Missense_Mutation_p.G78R			Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficking	78					endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	9						GGCCTCAGAGGGAATGAAATC	0.473000													6	65					0	0	8.12818e-05	0	0
EFEMP1	2202	broad.mit.edu	37	2	56098169	56098169	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:56098169G>A	ENST00000394555.2	-	9	1525	c.1090C>T	c.(1090-1092)Cct>Tct	p.P364S	EFEMP1_ENST00000394554.1_Missense_Mutation_p.P364S|EFEMP1_ENST00000355426.3_Missense_Mutation_p.P364S|EFEMP1_ENST00000424836.2_Missense_Mutation_p.P226S	NM_001039348.2|NM_001039349.2	NP_001034437.1|NP_001034438.1	Q12805	FBLN3_HUMAN	EGF containing fibulin-like extracellular matrix protein 1	364	EGF-like 6; calcium-binding (Potential).|Mediates interaction with TIMP3.				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity	p.P364S(1)		NS(1)|breast(2)|endometrium(4)|large_intestine(6)|lung(5)|ovary(5)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TCTTGACAAGGATTTCGTGGA	0.403000													6	55					0	0	0.00116845	0	0
FAM183B	340286	broad.mit.edu	37	7	38725506	38725506	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:38725506G>A	ENST00000409072.3	-	2	1034	c.100C>T	c.(100-102)Cac>Tac	p.H34Y						family with sequence similarity 183, member B											endometrium(1)|lung(7)	8						TACTGCGTGTGGAGTTTCTGG	0.537000													5	54					0	0	0.00116845	0	0
BAZ2B	29994	broad.mit.edu	37	2	160294890	160294890	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:160294890G>A	ENST00000392783.2	-	8	1712	c.1217C>T	c.(1216-1218)cCt>cTt	p.P406L	BAZ2B_ENST00000392782.1_Missense_Mutation_p.P404L|BAZ2B_ENST00000355831.2_Missense_Mutation_p.P406L|BAZ2B_ENST00000343439.5_Missense_Mutation_p.P404L	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	406					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						AAGAACATCAGGAGAAGGAAC	0.348000													7	47					0	0	8.12818e-05	0	0
PIWIL1	9271	broad.mit.edu	37	12	130847340	130847340	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:130847340G>A	ENST00000245255.3	+	17	2272	c.2000G>A	c.(1999-2001)aGa>aAa	p.R667K		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	667	Piwi.|RNA-binding (By similarity).				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		TTTCAGGATAGAGGACAGGAG	0.423000													9	50					0	0	0.000274275	0	0
DDHD2	23259	broad.mit.edu	37	8	38107265	38107265	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:38107265C>T	ENST00000397166.2	+	11	1813	c.1288C>T	c.(1288-1290)Cct>Tct	p.P430S	DDHD2_ENST00000520272.2_Missense_Mutation_p.P430S|DDHD2_ENST00000528888.1_3'UTR|DDHD2_ENST00000517385.1_Missense_Mutation_p.P49S	NM_015214.2	NP_056029.2	O94830	DDHD2_HUMAN	DDHD domain containing 2	430	SAM.				lipid catabolic process	centrosome	hydrolase activity|metal ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)|urinary_tract(2)	28	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			AATAGGAATTCCTTTAGGACC	0.348000													6	35					0	0	0.00116845	0	0
CRISPLD1	83690	broad.mit.edu	37	8	75928806	75928806	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:75928806C>T	ENST00000262207.4	+	7	1202	c.734C>T	c.(733-735)tCa>tTa	p.S245L	CRISPLD1_ENST00000523524.1_Missense_Mutation_p.S57L|CRISPLD1_ENST00000517786.1_Missense_Mutation_p.S59L	NM_031461.5	NP_113649.1	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain containing 1	245						extracellular region				biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			ACAGAAGGGTCAGACAGGTAT	0.358000													18	89					0	0	0.00074312	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146471374	146471374	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:146471374G>A	ENST00000361727.3	+	2	625	c.109G>A	c.(109-111)Gag>Aag	p.E37K		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	37	F5/8 type C.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AAAATGTGATGAGCCACTTGT	0.443000										HNSCC(39;0.1)			10	28					0	0	0.00185496	0	0
C18orf25	147339	broad.mit.edu	37	18	43843018	43843018	+	Silent	SNP	T	T	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr18:43843018T>A	ENST00000282059.6	+	5	1523	c.1149T>A	c.(1147-1149)gcT>gcA	p.A383A	C18orf25_ENST00000321319.6_Silent_p.A322A	NM_145055.3	NP_659492.1	Q96B23	CR025_HUMAN	chromosome 18 open reading frame 25	383										central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	11						AGACTTGGGCTTCACCAGCAG	0.493000													5	36					0	0	0.000602214	0	0
DGKB	1607	broad.mit.edu	37	7	14661117	14661117	+	Missense_Mutation	SNP	T	T	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:14661117T>A	ENST00000403951.2	-	15	1592	c.1173A>T	c.(1171-1173)gaA>gaT	p.E391D	DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000407950.1_Missense_Mutation_p.E383D|DGKB_ENST00000402815.1_Missense_Mutation_p.E390D|DGKB_ENST00000406247.3_Missense_Mutation_p.E391D|DGKB_ENST00000258767.5_Missense_Mutation_p.E391D|DGKB_ENST00000399322.3_Missense_Mutation_p.E391D|DGKB_ENST00000444700.2_Missense_Mutation_p.E372D			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	391					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	TTGATTGTCTTTCCTGTAAAA	0.289000													8	16					0	0	0.000274275	0	0
HAO2	51179	broad.mit.edu	37	1	119927555	119927555	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:119927555C>T	ENST00000361035.4	+	5	762	c.479C>T	c.(478-480)tCc>tTc	p.S160F	HAO2_ENST00000325945.3_Missense_Mutation_p.S147F	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	147	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		AGGGTAGAATCCCTAGGTTTC	0.463000													14	78					0	0	0.000422831	0	0
CDH23	64072	broad.mit.edu	37	10	73406389	73406389	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr10:73406389C>T	ENST00000398809.4	+	14	1854	c.1464C>T	c.(1462-1464)ttC>ttT	p.F488F	CDH23_ENST00000299366.7_Intron|CDH23_ENST00000461841.3_Silent_p.F533F|CDH23_ENST00000398842.3_Silent_p.F488F|CDH23_ENST00000224721.6_Intron	NM_052836.3	NP_443068.1	Q9H251	CAD23_HUMAN	cadherin-related 23	0	Cadherin 5.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GTCCCCGCTTCACTGCAGGGC	0.602000													7	63					0	0	0.000442599	0	0
PPM1E	22843	broad.mit.edu	37	17	57043082	57043082	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:57043082C>T	ENST00000308249.2	+	3	740	c.611C>T	c.(610-612)tCt>tTt	p.S204F		NM_014906.4	NP_055721.3	Q8WY54	PPM1E_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1E	213					protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			TTGGCCCGTTCTGTCTTCAGC	0.463000													39	218					0	0	0.000437636	0	0
C2orf16	84226	broad.mit.edu	37	2	27800558	27800558	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:27800558G>A	ENST00000408964.2	+	1	1170	c.1119G>A	c.(1117-1119)gaG>gaA	p.E373E		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	373								p.E373D(1)		breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					TGCAGGTAGAGAAAACTTTGC	0.463000													8	43					0	0	0.000274275	0	0
CNGB3	54714	broad.mit.edu	37	8	87666270	87666270	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:87666270C>T	ENST00000320005.5	-	7	920	c.873G>A	c.(871-873)agG>agA	p.R291R		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	291					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						TGTAGTGTTTCCTTAGCTCAT	0.289000													7	59					0	0	8.12818e-05	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29230729	29230729	+	RNA	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:29230729G>A	ENST00000441381.1	+	0	79																											GTGATGCAAGGAAAATGAAAA	0.398000													9	37					0	0	0.000274275	0	0
ZNF2	7549	broad.mit.edu	37	2	95845936	95845936	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:95845936C>T	ENST00000398107.2	+	3	589	c.67C>T	c.(67-69)Caa>Taa	p.Q23*	ZNF2_ENST00000340539.5_Nonsense_Mutation_p.Q65*|ZNF2_ENST00000453539.2_Nonsense_Mutation_p.Q65*|ZNF2_ENST00000295210.6_Intron|ZNF2_ENST00000425369.1_Intron	NM_001017396.1	NP_001017396.1	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2	65	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	12		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		TGTGATTTTCCAATTGAAGAG	0.463000													13	96					0	0	0.000219431	0	0
AXDND1	126859	broad.mit.edu	37	1	179462017	179462017	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:179462017G>A	ENST00000367618.3	+	20	2706	c.2319G>A	c.(2317-2319)atG>atA	p.M773I		NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	773										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						TAACAGCAATGGCTCTGAGTA	0.373000													10	55					0	0	0.000673444	0	0
EYA2	2139	broad.mit.edu	37	20	45644851	45644851	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr20:45644851C>T	ENST00000327619.5	+	5	704	c.330C>T	c.(328-330)tcC>tcT	p.S110S	EYA2_ENST00000317304.6_Silent_p.S110S|EYA2_ENST00000357410.3_Silent_p.S110S	NM_005244.4	NP_005235.3	O00167	EYA2_HUMAN	eyes absent homolog 2 (Drosophila)	110					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0241)				TGAACCATTCCCCTGGCCAGA	0.532000													14	117					0	0	0.000308642	0	0
OR10A5	144124	broad.mit.edu	37	11	6867192	6867192	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:6867192C>T	ENST00000299454.4	+	1	310	c.279C>T	c.(277-279)atC>atT	p.I93I	OR10A5_ENST00000379831.2_Silent_p.I97I			Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A, member 5	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	21		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ACACAACCATCTCCTTCCTTG	0.493000													8	64					0	0	0.000442599	0	0
CENPJ	55835	broad.mit.edu	37	13	25484108	25484108	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr13:25484108C>T	ENST00000381884.4	-	4	870	c.685G>A	c.(685-687)Gaa>Aaa	p.E229K	CENPJ_ENST00000545981.1_Missense_Mutation_p.E229K	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	229					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		TATGTTTCTTCCTGGGTTGGG	0.473000													19	104					0	0	0.00121646	0	0
NPAS4	266743	broad.mit.edu	37	11	66191943	66191943	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:66191943C>T	ENST00000311034.2	+	7	1758	c.1582C>T	c.(1582-1584)Cat>Tat	p.H528Y		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	528					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CAGCCCTGCCCATGAACAGCT	0.592000													13	134					0	0	0.000219431	0	0
DNAH5	1767	broad.mit.edu	37	5	13762921	13762921	+	Silent	SNP	T	T	C			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:13762921T>C	ENST00000265104.4	-	60	10295	c.10191A>G	c.(10189-10191)aaA>aaG	p.K3397K	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3397	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CACATACGCGTTTAGCAGTTT	0.398000									Kartagener syndrome				5	73					0	0	8.12818e-05	0	0
IGHV1OR15-9	390531	broad.mit.edu	37	15	20170215	20170215	+	RNA	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr15:20170215G>A	ENST00000338912.5	-	0	56																											GCTGTACCTGGGACTGGGCAC	0.557000													12	36					0	0	0.00185496	0	0
SNHG14	104472715	broad.mit.edu	37	15	25296640	25296640	+	RNA	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr15:25296640C>T	ENST00000549804.2	+	0	98				SNHG14_ENST00000552781.1_RNA|SNHG14_ENST00000547292.1_RNA|SNORD116-1_ENST00000384335.1_RNA																							ATGATGAGTCCCCTATAAAAA	0.473000													6	67					0	0	0.000157383	0	0
GHSR	2693	broad.mit.edu	37	3	172165933	172165933	+	Missense_Mutation	SNP	G	G	A	rs79053943	byFrequency	TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:172165933G>A	ENST00000241256.2	-	1	313	c.271C>T	c.(271-273)Ctc>Ttc	p.L91F	GHSR_ENST00000427970.1_Missense_Mutation_p.L91F	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	91					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			AGGAAGATGAGCAGATCGGAG	0.607000													5	31					0	0	8.12818e-05	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													5	49					0	0	0.000602214	0	0
ABCA9	10350	broad.mit.edu	37	17	66981228	66981228	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:66981228G>A	ENST00000340001.4	-	33	4461	c.4250C>T	c.(4249-4251)cCc>cTc	p.P1417L	ABCA9_ENST00000453985.2_Missense_Mutation_p.P1379L|ABCA9_ENST00000370732.2_Missense_Mutation_p.P1417L	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	1417	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					GGTCTTCACGGGAGCCTTCAG	0.527000													5	62					0	0	0.000602214	0	0
FHOD3	80206	broad.mit.edu	37	18	33952695	33952695	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr18:33952695C>T	ENST00000257209.4	+	3	447	c.325C>T	c.(325-327)Cat>Tat	p.H109Y	FHOD3_ENST00000590592.1_Missense_Mutation_p.H109Y|FHOD3_ENST00000359247.4_Missense_Mutation_p.H109Y|FHOD3_ENST00000445677.1_Missense_Mutation_p.H109Y	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	109	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				TGTGAGGGTCCATGCCTGCAT	0.498000													4	16					0	0	0.00116845	0	0
KCNH2	3757	broad.mit.edu	37	7	150648860	150648860	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:150648860G>A	ENST00000392968.2	-	5	2453	c.1333C>T	c.(1333-1335)Cgc>Tgc	p.R445C	KCNH2_ENST00000430723.3_Missense_Mutation_p.R541C|KCNH2_ENST00000262186.5_Missense_Mutation_p.R541C|KCNH2_ENST00000330883.4_Missense_Mutation_p.R201C			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	541					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TCTGAGTAGCGATCCAGCTTC	0.642000													4	23					0	0	0.00024832	0	0
PENK	5179	broad.mit.edu	37	8	57354177	57354177	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:57354177G>A	ENST00000314922.3	-	2	534	c.458C>T	c.(457-459)tCc>tTc	p.S153F	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Missense_Mutation_p.S153F	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	153					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity	p.S153C(1)		central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			CAGGTCTGAGGAATTGGCCAG	0.527000													19	76					0	0	0.00074312	0	0
ECE1	1889	broad.mit.edu	37	1	21551766	21551766	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:21551766C>T	ENST00000415912.2	-	17	2094	c.1969G>A	c.(1969-1971)Ggg>Agg	p.G657R	ECE1_ENST00000436918.2_Missense_Mutation_p.G673R|ECE1_ENST00000357071.4_Missense_Mutation_p.G661R|ECE1_ENST00000264205.6_Missense_Mutation_p.G670R|ECE1_ENST00000374893.6_Missense_Mutation_p.G673R	NM_001113348.1	NP_001106819.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	673					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		TTGAGACCCCCGTTGTCGGCG	0.647000													5	49					0	0	0.00116845	0	0
PPP1R16A	84988	broad.mit.edu	37	8	145722800	145722800	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:145722800C>T	ENST00000292539.4	+	2	1140	c.223C>T	c.(223-225)Ctt>Ttt	p.L75F	CTD-2517M22.14_ENST00000532766.1_RNA|CTD-2517M14.5_ENST00000569326.1_RNA|PPP1R16A_ENST00000435887.1_Missense_Mutation_p.L75F			Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory subunit 16A	75						plasma membrane	protein binding			NS(1)|endometrium(1)|kidney(2)|lung(3)|prostate(1)	8	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CAGTGTTGTCCTTCTGGAGGC	0.657000													7	22					0	0	0.000157383	0	0
SLC6A4	6532	broad.mit.edu	37	17	28537552	28537552	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:28537552G>A	ENST00000401766.2	-	10	1942	c.1430C>T	c.(1429-1431)tCc>tTc	p.S477F	SLC6A4_ENST00000261707.3_Missense_Mutation_p.S477F			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	477					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	GGTGACCAGGGATCCAAAGAA	0.592000													8	47					0	0	0.000157383	0	0
SERPINF2	5345	broad.mit.edu	37	17	1657539	1657539	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:1657539C>T	ENST00000324015.3	+	10	1264	c.1187C>T	c.(1186-1188)gCc>gTc	p.A396V	SERPINF2_ENST00000382061.4_Missense_Mutation_p.A396V|SERPINF2_ENST00000450523.2_Missense_Mutation_p.A332V	NM_000934.3	NP_000925.2	P08697	A2AP_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	396					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	GCGGCGGCGGCCACCAGCATT	0.652000													15	95					0	0	0.000308642	0	0
ZDHHC13	54503	broad.mit.edu	37	11	19187864	19187864	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:19187864A>G	ENST00000446113.2	+	14	1527	c.1406A>G	c.(1405-1407)cAc>cGc	p.H469R	ZDHHC13_ENST00000399351.3_Missense_Mutation_p.H339R	NM_019028.2	NP_061901.2	Q8IUH4	ZDH13_HUMAN	zinc finger, DHHC-type containing 13	469					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|palmitoyltransferase activity|signal transducer activity|zinc ion binding			NS(1)|kidney(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6						GGCAACCATCACTATTACATA	0.313000													5	34					0	0	0.000602214	0	0
PPP4R1	9989	broad.mit.edu	37	18	9557296	9557296	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr18:9557296G>A	ENST00000400556.3	-	15	2186	c.2113C>T	c.(2113-2115)Cca>Tca	p.P705S	PPP4R1_ENST00000400555.3_Missense_Mutation_p.P688S	NM_001042388.2	NP_001035847.1	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	705					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			large_intestine(1)|skin(2)	3						TTAAAAATTGGAACCAGATCT	0.368000													26	229					0	0	0.00178596	0	0
SCN11A	11280	broad.mit.edu	37	3	38936347	38936347	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:38936347G>A	ENST00000450244.1	-	15	2710	c.2512C>T	c.(2512-2514)Cga>Tga	p.R838*	SCN11A_ENST00000456224.3_Nonsense_Mutation_p.R838*|SCN11A_ENST00000302328.3_Nonsense_Mutation_p.R838*|SCN11A_ENST00000444237.2_Nonsense_Mutation_p.R838*			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	838					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CGGCGGAATCGATCCAGTGCT	0.453000													10	61					0	0	0.000442599	0	0
CREBBP	1387	broad.mit.edu	37	16	3823810	3823810	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr16:3823810G>A	ENST00000262367.5	-	13	3214	c.2405C>T	c.(2404-2406)tCc>tTc	p.S802F	CREBBP_ENST00000382070.3_Missense_Mutation_p.S764F	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	802					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CGCCCCGCTGGATGACGGGAA	0.607000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						7	58					0	0	0.000157383	0	0
PDE10A	10846	broad.mit.edu	37	6	165792793	165792793	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:165792793G>A	ENST00000366882.1	-	19	1999	c.1845C>T	c.(1843-1845)atC>atT	p.I615I	PDE10A_ENST00000539869.2_Silent_p.I625I|PDE10A_ENST00000354448.4_Silent_p.I615I			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	615					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CTTTGCGGATGATCTCAAGCA	0.418000													7	72					0	0	0.000442599	0	0
OR4K5	79317	broad.mit.edu	37	14	20388883	20388883	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:20388883C>T	ENST00000315915.4	+	1	143	c.118C>T	c.(118-120)Ctg>Ttg	p.L40L		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGTCATTGTGCTGGGAAATCT	0.403000													15	113					0	0	0.000422831	0	0
ZNF229	7772	broad.mit.edu	37	19	44934623	44934623	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:44934623C>T	ENST00000291187.4	-	6	637	c.315G>A	c.(313-315)gaG>gaA	p.E105E	CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000588931.1_Silent_p.E111E|ZNF229_ENST00000591289.1_Intron	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	111	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				CACCTGCCACCTCTTCCCAGA	0.443000													7	48					0	0	8.12818e-05	0	0
FOXN2	3344	broad.mit.edu	37	2	48586237	48586237	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:48586237C>T	ENST00000340553.3	+	4	850	c.589C>T	c.(589-591)Ctt>Ttt	p.L197F		NM_002158.3	NP_002149.2	P32314	FOXN2_HUMAN	forkhead box N2	197					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			TAAACCCAATCTTATCCAGGC	0.353000													5	63					0	0	0.000602214	0	0
MED13	9969	broad.mit.edu	37	17	60060354	60060354	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:60060354G>A	ENST00000397786.2	-	16	3086	c.3010C>T	c.(3010-3012)Cca>Tca	p.P1004S		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1004					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GGGGTGGATGGAGAAGGAAGA	0.507000													6	37					0	0	0.000157383	0	0
LCT	3938	broad.mit.edu	37	2	136566908	136566908	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:136566908C>T	ENST00000264162.2	-	8	3019	c.3009G>A	c.(3007-3009)ctG>ctA	p.L1003L		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1003	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		AGCCATTGATCAGCCTGTTGT	0.517000													5	44					0	0	0.000602214	0	0
MYLK	4638	broad.mit.edu	37	3	123419615	123419615	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:123419615G>A	ENST00000360772.3	-	19	3078	c.2700C>T	c.(2698-2700)ctC>ctT	p.L900L	MYLK_ENST00000475616.1_Silent_p.L900L|MYLK_ENST00000346322.5_Silent_p.L831L|MYLK_ENST00000360304.3_Silent_p.L900L|MYLK_ENST00000359169.1_Silent_p.L900L			Q15746	MYLK_HUMAN	myosin light chain kinase	900	5 X 28 AA approximate tandem repeats.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TCTTCCCCAGGAGGTCTCGGA	0.612000													5	48					0	0	0.000602214	0	0
TNIK	23043	broad.mit.edu	37	3	170786639	170786639	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:170786639G>A	ENST00000436636.2	-	30	4041	c.3697C>T	c.(3697-3699)Cat>Tat	p.H1233Y	TNIK_ENST00000488470.1_Missense_Mutation_p.H1178Y|TNIK_ENST00000460047.1_Missense_Mutation_p.H1170Y|TNIK_ENST00000369326.5_Missense_Mutation_p.H1211Y|TNIK_ENST00000357327.5_Missense_Mutation_p.H1204Y|TNIK_ENST00000284483.8_Missense_Mutation_p.H1225Y|TNIK_ENST00000341852.6_Missense_Mutation_p.H1149Y|TNIK_ENST00000470834.1_Missense_Mutation_p.H1196Y|TNIK_ENST00000538048.1_Missense_Mutation_p.H1185Y|TNIK_ENST00000475336.1_Missense_Mutation_p.H1141Y	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	1233	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GTACTTACATGAGATGGTATG	0.363000													7	39					0	0	0.000157383	0	0
NUP210L	91181	broad.mit.edu	37	1	153998161	153998161	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:153998161G>A	ENST00000368559.3	-	30	4050	c.3979C>T	c.(3979-3981)Ctc>Ttc	p.L1327F	NUP210L_ENST00000368553.1_Missense_Mutation_p.L260F|NUP210L_ENST00000271854.3_Missense_Mutation_p.L1327F	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	1327						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AAACACTTGAGAACACGAGAA	0.468000													22	191					0	0	0.000295444	0	0
ADCK2	90956	broad.mit.edu	37	7	140373513	140373513	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:140373513C>T	ENST00000072869.4	+	1	561	c.383C>T	c.(382-384)aCc>aTc	p.T128I	ADCK2_ENST00000476491.1_Missense_Mutation_p.T128I	NM_052853.3	NP_443085.2	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	128						integral to membrane	ATP binding|protein serine/threonine kinase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|skin(4)	15	Melanoma(164;0.00956)					AGCGTCTCCACCCTCTGGCTC	0.627000													6	82					0	0	8.12818e-05	0	0
DBN1	1627	broad.mit.edu	37	5	176886132	176886132	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:176886132G>A	ENST00000292385.5	-	12	1708	c.1099C>T	c.(1099-1101)Cca>Tca	p.P367S	DBN1_ENST00000393563.4_Missense_Mutation_p.P97S|DBN1_ENST00000393565.1_Missense_Mutation_p.P411S|DBN1_ENST00000309007.5_Missense_Mutation_p.P365S|DBN1_ENST00000512501.1_Missense_Mutation_p.P97S	NM_080881.2	NP_543157.1	Q16643	DREB_HUMAN	drebrin 1	365					actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(12)|ovary(1)|skin(2)	25	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCAGTGGTGGAGGCTGCGAG	0.677000													10	70					0	0	0.000978159	0	0
KAT8	84148	broad.mit.edu	37	16	31141818	31141818	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr16:31141818G>A	ENST00000543774.2	+	10	1383	c.1048G>A	c.(1048-1050)Gag>Aag	p.E350K	KAT8_ENST00000448516.2_Missense_Mutation_p.E350K|KAT8_ENST00000219797.4_Missense_Mutation_p.E350K			Q9H7Z6	MYST1_HUMAN	K(lysine) acetyltransferase 8	350					histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding										CGGCTCCCCGGAGAAGCCACT	0.607000													6	22					0	0	8.12818e-05	0	0
ST18	9705	broad.mit.edu	37	8	53092745	53092745	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:53092745C>T	ENST00000276480.7	-	9	897	c.214G>A	c.(214-216)Gaa>Aaa	p.E72K		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	72						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CTGCGGTCTTCTTGGCAGTCT	0.532000													18	150					0	0	0.000958276	0	0
SLCO1B7	338821	broad.mit.edu	37	12	21172247	21172247	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:21172247G>A	ENST00000421593.2	+	2	151	c.151G>A	c.(151-153)Gga>Aga	p.G51R	LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000554957.1_Intron|SLCO1B3_ENST00000553473.1_Intron|LST3_ENST00000381541.3_Intron	NM_001009562.4	NP_001009562.3			solute carrier organic anion transporter family, member 1B7 (non-functional)											endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(25)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						GAAGTTAATTGGAATTGGTTG	0.328000													10	44					0	0	0.000442599	0	0
KCNE1	3753	broad.mit.edu	37	21	35821668	35821668	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr21:35821668C>T	ENST00000337385.3	-	3	640	c.265G>A	c.(265-267)Gag>Aag	p.E89K	KCNE1_ENST00000399289.3_Missense_Mutation_p.E89K|KCNE1_ENST00000399284.1_Missense_Mutation_p.E89K|KCNE1_ENST00000432085.1_Missense_Mutation_p.E89K|KCNE1_ENST00000399286.2_Missense_Mutation_p.E89K|KCNE1_ENST00000416357.2_Missense_Mutation_p.E89K	NM_001270402.1|NM_001270403.1	NP_001257331.1|NP_001257332.1	P15382	KCNE1_HUMAN	potassium voltage-gated channel, Isk-related family, member 1	89					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound	lysosome	delayed rectifier potassium channel activity|potassium channel regulator activity			large_intestine(4)|lung(1)|ovary(2)	7					Indapamide(DB00808)	TTGTCCTTCTCTTGCCAGGCA	0.547000													42	370					0	0	0.00148497	0	0
ICA1L	130026	broad.mit.edu	37	2	203693608	203693608	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:203693608A>G	ENST00000392237.2	-	3	282	c.125T>C	c.(124-126)tTg>tCg	p.L42S	ICA1L_ENST00000358299.2_Missense_Mutation_p.L42S|ICA1L_ENST00000418208.1_Missense_Mutation_p.L42S|ICA1L_ENST00000425178.1_Missense_Mutation_p.L42S	NM_138468.4	NP_612477.3	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like	42										breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AGACGCCACCAAGTGCTCATC	0.398000													60	551					0	0	0.000781405	0	0
SCN2A	6326	broad.mit.edu	37	2	166234156	166234156	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:166234156G>A	ENST00000375437.2	+	23	4594	c.4304G>A	c.(4303-4305)cGa>cAa	p.R1435Q	SCN2A_ENST00000375427.2_Missense_Mutation_p.R1435Q|SCN2A_ENST00000283256.6_Missense_Mutation_p.R1435Q|SCN2A_ENST00000357398.3_Missense_Mutation_p.R1435Q	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1435					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GTTGATTCACGAAATGTAAGT	0.269000													7	68					0	0	0.000274275	0	0
MGAM	8972	broad.mit.edu	37	7	141752605	141752605	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:141752605C>T	ENST00000475668.2	+	26	3034	c.2980C>T	c.(2980-2982)Cct>Tct	p.P994S	MGAM_ENST00000549489.2_Missense_Mutation_p.P994S			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	994	P-type 2.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TTCTGGAGTCCCTTTTTGCTA	0.418000													12	103					0	0	0.000422831	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73074358	73074358	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:73074358C>T	ENST00000263674.3	+	15	5454	c.5104C>T	c.(5104-5106)Ccc>Tcc	p.P1702S		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1702					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						GCCTGGTGGTCCCTGCGGCAC	0.667000													5	22					0	0	0.000602214	0	0
UNC13C	440279	broad.mit.edu	37	15	54306429	54306429	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr15:54306429G>A	ENST00000545554.1	+	1	1329	c.1329G>A	c.(1327-1329)aaG>aaA	p.K443K	UNC13C_ENST00000537900.1_Silent_p.K443K|UNC13C_ENST00000260323.11_Silent_p.K443K			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	443					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AAATCAAGAAGAACAATTGGC	0.418000													24	113					0	0	0.00047179	0	0
FSTL4	23105	broad.mit.edu	37	5	132648406	132648406	+	Nonsense_Mutation	SNP	G	G	A	rs148048628		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:132648406G>A	ENST00000265342.7	-	6	916	c.667C>T	c.(667-669)Cga>Tga	p.R223*		NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	223						extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCGTCAAATCGGAGGAGGTCA	0.527000													5	39					0	0	0.00116845	0	0
OR4Q3	441669	broad.mit.edu	37	14	20215844	20215844	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:20215844C>T	ENST00000331723.1	+	1	258	c.258C>T	c.(256-258)ttC>ttT	p.F86F		NM_172194.1	NP_751944.1	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q, member 3	86					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(4)|endometrium(3)|kidney(2)|large_intestine(1)|lung(28)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TAGGGGATTTCCTACAGCAGG	0.458000													5	52					0	0	0.00116845	0	0
UIMC1	51720	broad.mit.edu	37	5	176395770	176395770	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:176395770G>A	ENST00000377219.2	-	6	1152	c.986C>T	c.(985-987)cCt>cTt	p.P329L	UIMC1_ENST00000511320.1_Missense_Mutation_p.P329L|UIMC1_ENST00000503273.1_5'UTR|UIMC1_ENST00000377227.4_Missense_Mutation_p.P329L|UIMC1_ENST00000506128.1_Intron	NM_016290.4	NP_057374.3	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	329	AIR.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(5)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	21	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GATCAGAGAAGGAGGTCTAGG	0.448000													18	81					0	0	0.000566183	0	0
FRMPD4	9758	broad.mit.edu	37	X	12736900	12736900	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chrX:12736900G>A	ENST00000380682.1	+	16	4461	c.3955G>A	c.(3955-3957)Gaa>Aaa	p.E1319K		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1319					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CAAGATTAAGGAAACCACAGG	0.453000													15	42					0	0	0.000308642	0	0
TRIM55	84675	broad.mit.edu	37	8	67066444	67066444	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:67066444G>A	ENST00000315962.4	+	9	1772	c.1399G>A	c.(1399-1401)Ggg>Agg	p.G467R	TRIM55_ENST00000276573.7_Missense_Mutation_p.G467R|TRIM55_ENST00000353317.5_Intron|TRIM55_ENST00000350034.4_Intron	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	467						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			CGAAGGTCTGGGGCAAATAGG	0.562000													5	25					0	0	0.00116845	0	0
MUC17	140453	broad.mit.edu	37	7	100677629	100677629	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:100677629C>T	ENST00000306151.4	+	3	2996	c.2932C>T	c.(2932-2934)Cct>Tct	p.P978S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	978	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACCTCGACTCCTAGTGAAGG	0.507000													24	182					0	0	0.000375601	0	0
SYTL4	94121	broad.mit.edu	37	X	99956480	99956480	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chrX:99956480C>T	ENST00000372981.1	-	3	486	c.300G>A	c.(298-300)tgG>tgA	p.W100*	SYTL4_ENST00000276141.6_Nonsense_Mutation_p.W100*|SYTL4_ENST00000455616.1_Nonsense_Mutation_p.W100*|SYTL4_ENST00000372989.1_Nonsense_Mutation_p.W100*|SYTL4_ENST00000263033.5_Nonsense_Mutation_p.W100*|SYTL4_ENST00000454200.2_Nonsense_Mutation_p.W100*			Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	100	RabBD.				exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(2)	27					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCTTGCACCTCCAGGTACCAT	0.547000													13	32					0	0	0.000422831	0	0
OR4C15	81309	broad.mit.edu	37	11	55322146	55322146	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:55322146C>T	ENST00000314644.2	+	1	364	c.364C>T	c.(364-366)Ctg>Ttg	p.L122L		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						CCTGTCCTTCCTGGATGCGTG	0.473000										HNSCC(20;0.049)			17	145					0	0	0.00074312	0	0
TLR7	51284	broad.mit.edu	37	X	12906163	12906163	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chrX:12906163T>C	ENST00000380659.3	+	3	2675	c.2536T>C	c.(2536-2538)Tcc>Ccc	p.S846P		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	846					cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	GTTCTCACTTTCCATATCTGT	0.443000													15	63					0	0	0.000422831	0	0
DZIP1	22873	broad.mit.edu	37	13	96293836	96293836	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr13:96293836C>T	ENST00000347108.3	-	3	742	c.310G>A	c.(310-312)Gag>Aag	p.E104K	DZIP1_ENST00000376829.2_Missense_Mutation_p.E104K|DZIP1_ENST00000361156.3_Missense_Mutation_p.E104K|DZIP1_ENST00000466027.1_5'UTR|DZIP1_ENST00000361396.2_Missense_Mutation_p.E104K			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	104					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			GGGCACTTCTCGTCTTCCAGC	0.602000													12	66					0	0	0.00185496	0	0
ACACA	31	broad.mit.edu	37	17	35598957	35598957	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:35598957G>A	ENST00000353139.5	-	23	3425	c.2944C>T	c.(2944-2946)Cta>Tta	p.L982L	ACACA_ENST00000394406.2_Silent_p.L945L|ACACA_ENST00000360679.3_Silent_p.L887L|ACACA_ENST00000335166.5_Silent_p.L867L	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	945					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TGGCTATCTAGGATGTTTGCA	0.423000													6	58					0	0	0.00116845	0	0
CCDC88C	440193	broad.mit.edu	37	14	91739956	91739956	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:91739956G>A	ENST00000389857.6	-	30	5186	c.5100C>T	c.(5098-5100)ttC>ttT	p.F1700F	CCDC88C_ENST00000331194.7_Silent_p.F224F	NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1700					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				TGGCCTTTCGGAAGTAGTCAC	0.607000													10	41					0	0	0.00185496	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20369288	20369288	+	RNA	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:20369288G>A	ENST00000593655.1	-	0	199																											TACGAAATTGGGATGACACGA	0.373000													18	92					0	0	0.000958276	0	0
FBXO9	26268	broad.mit.edu	37	6	52957292	52957292	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:52957292C>T	ENST00000244426.6	+	7	921	c.749C>T	c.(748-750)cCg>cTg	p.P250L	FBXO9_ENST00000370939.3_Missense_Mutation_p.P206L|FBXO9_ENST00000323557.7_Missense_Mutation_p.P240L	NM_012347.4	NP_036479.1	Q9UK97	FBX9_HUMAN	F-box protein 9	250						ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)|large_intestine(4)|lung(1)|pancreas(2)|skin(1)	9	Lung NSC(77;0.103)					AAACTTGTTCCGTACACGTCC	0.418000													13	123					0	0	0.000219431	0	0
SMPD2	6610	broad.mit.edu	37	6	109763198	109763198	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:109763198C>T	ENST00000258052.3	+	4	605	c.246C>T	c.(244-246)ctC>ctT	p.L82L		NM_003080.2	NP_003071.2	O60906	NSMA_HUMAN	sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)	82					induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|sphingomyelin metabolic process	integral to plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			endometrium(2)|lung(3)|stomach(1)|upper_aerodigestive_tract(2)	8		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.0137)|all cancers(137;0.0188)|OV - Ovarian serous cystadenocarcinoma(136;0.0228)|BRCA - Breast invasive adenocarcinoma(108;0.0566)		GCAGTGGCCTCTGTGTCTTCT	0.517000													31	184					0	0	0.000953801	0	0
NCOA4	8031	broad.mit.edu	37	10	51585487	51585487	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr10:51585487C>T	ENST00000452682.1	+	9	1886	c.1634C>T	c.(1633-1635)aCt>aTt	p.T545I	NCOA4_ENST00000438493.1_Missense_Mutation_p.T545I|NCOA4_ENST00000414907.2_Missense_Mutation_p.T363I|NCOA4_ENST00000443446.1_Missense_Mutation_p.T529I|NCOA4_ENST00000374087.4_Missense_Mutation_p.T529I|NCOA4_ENST00000374082.1_Intron|NCOA4_ENST00000344348.6_Missense_Mutation_p.T529I|NCOA4_ENST00000430396.2_Missense_Mutation_p.T429I	NM_001145260.1	NP_001138732.1	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4	529					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|skin(1)	5						CCCATGAATACTTCCTGGTGT	0.498000			T	RET	papillary thyroid								10	91					0	0	0.000442599	0	0
ZBTB18	10472	broad.mit.edu	37	1	244217908	244217908	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:244217908C>T	ENST00000358704.4	+	2	981	c.832C>T	c.(832-834)Ctg>Ttg	p.L278L		NM_001278196.1|NM_006352.4|NM_205768.2	NP_001265125.1|NP_006343.2|NP_991331.1			zinc finger and BTB domain containing 18																		GAGAAGCAACCTGGTGCAGGT	0.468000													7	50					0	0	0.000442599	0	0
OR1C1	26188	broad.mit.edu	37	1	247920941	247920941	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:247920941G>A	ENST00000408896.2	-	1	1041	c.768C>T	c.(766-768)atC>atT	p.I256I		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AATAGACGGCGATGGCTGTGC	0.522000													7	43					0	0	8.12818e-05	0	0
ACR	49	broad.mit.edu	37	22	51178298	51178298	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr22:51178298C>T	ENST00000216139.5	+	3	498	c.458C>T	c.(457-459)tCg>tTg	p.S153L	ACR_ENST00000529621.1_Missense_Mutation_p.S153L	NM_001097.2	NP_001088.2	P10323	ACRO_HUMAN	acrosin	153	Peptidase S1.				acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)		CCTCCCATTTCGTGTGGGCGC	0.547000													12	77					0	0	0.00136819	0	0
PNPO	55163	broad.mit.edu	37	17	46022027	46022027	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:46022027G>A	ENST00000225573.4	+	3	414	c.309G>A	c.(307-309)ggG>ggA	p.G103G	PNPO_ENST00000534893.1_Silent_p.G8G|PNPO_ENST00000544840.1_Silent_p.G103G|PNPO_ENST00000434554.2_Silent_p.G103G	NM_018129.3	NP_060599.1	Q9NVS9	PNPO_HUMAN	pyridoxamine 5'-phosphate oxidase	103					pyridoxine biosynthetic process	cytosol	FMN binding|pyridoxamine-phosphate oxidase activity			endometrium(2)|large_intestine(1)|lung(1)|urinary_tract(1)	5					Pyridoxal Phosphate(DB00114)	AGGGCTTCGGGAAAGATGGCT	0.502000													28	157					0	0	0.001512	0	0
TTBK1	84630	broad.mit.edu	37	6	43220587	43220587	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:43220587C>T	ENST00000259750.4	+	3	302	c.219C>T	c.(217-219)gtC>gtT	p.V73V	TTBK1_ENST00000304139.5_Silent_p.V22V	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	73	Protein kinase.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CCAAGCAGGTCCTCAAGATGG	0.617000													9	56					0	0	0.000673444	0	0
KSR2	283455	broad.mit.edu	37	12	118198993	118198993	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:118198993G>A	ENST00000425217.1	-	4	776	c.722C>T	c.(721-723)aCc>aTc	p.T241I	KSR2_ENST00000339824.5_Missense_Mutation_p.T270I	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	270	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGGGGTCACGGTGGTGACGAT	0.721000													23	167					0	0	0.00047179	0	0
IDH1	3417	broad.mit.edu	37	2	209116179	209116179	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:209116179G>A	ENST00000415913.1	-	3	478	c.97C>T	c.(97-99)Ccc>Tcc	p.P33S	IDH1_ENST00000345146.2_Missense_Mutation_p.P33S|IDH1_ENST00000446179.1_Missense_Mutation_p.P33S			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	33					2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.P33S(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TCCACGTAGGGAAAAATGAGT	0.423000			Mis		gliobastoma								9	61					0	0	0.000274275	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166862232	166862232	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:166862232C>T	ENST00000510118.1	-	16	1727	c.1387G>A	c.(1387-1389)Gac>Aac	p.D463N	RPS6KA2_ENST00000481261.2_Missense_Mutation_p.D349N|RPS6KA2_ENST00000265678.4_Missense_Mutation_p.D438N|RPS6KA2_ENST00000405189.3_Missense_Mutation_p.D349N|RPS6KA2_ENST00000503859.1_Missense_Mutation_p.D446N			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	438	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.D438N(1)|p.D446N(1)		central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		TACTCGGTGTCTGTGGCTTTA	0.587000													5	10					0	0	0.000602214	0	0
AAMP	14	broad.mit.edu	37	2	219134700	219134700	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:219134700G>A	ENST00000248450.4	-	1	280	c.110C>T	c.(109-111)cCg>cTg	p.P37L	AAMP_ENST00000444053.1_Missense_Mutation_p.P37L			Q13685	AAMP_HUMAN	angio-associated, migratory cell protein	37					angiogenesis|cell differentiation|positive regulation of endothelial cell migration|smooth muscle cell migration	cell surface|cytoplasm|plasma membrane	heparin binding			haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(4)|ovary(2)|skin(1)	11		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGGTCCGGCGGACCGGGATC	0.622000													16	95					0	0	0.000308642	0	0
TNFRSF8	943	broad.mit.edu	37	1	12175638	12175638	+	Missense_Mutation	SNP	C	C	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:12175638C>A	ENST00000263932.2	+	8	1020	c.798C>A	c.(796-798)gaC>gaA	p.D266E	TNFRSF8_ENST00000417814.2_Missense_Mutation_p.D155E	NM_001243.3	NP_001234.2	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	266					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		CCTTAGATGACCTTGTGGAGA	0.572000													7	92					2.17888e-05	0.000111011	0.000442599	1	0
S1PR1	1901	broad.mit.edu	37	1	101705419	101705419	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:101705419G>A	ENST00000305352.6	+	2	1254	c.879G>A	c.(877-879)gcG>gcA	p.A293A		NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	293					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity	p.A293A(1)		NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						TCTTCAGAGCGGAGTACTTCC	0.562000													26	151					0	0	0.00106085	0	0
SCN10A	6336	broad.mit.edu	37	3	38770223	38770223	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:38770223C>T	ENST00000449082.2	-	15	2449	c.2450G>A	c.(2449-2451)cGa>cAa	p.R817Q		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	817					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GATATTTTTTCGGTTGTTACG	0.537000													8	46					0	0	0.000274275	0	0
ALKBH2	121642	broad.mit.edu	37	12	109530455	109530455	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:109530455G>A	ENST00000429722.2	-	2	500	c.137C>T	c.(136-138)cCa>cTa	p.P46L	ALKBH2_ENST00000343075.3_Missense_Mutation_p.P46L|ALKBH2_ENST00000440112.2_Missense_Mutation_p.P46L	NM_001145374.1	NP_001138846.1	Q6NS38	ALKB2_HUMAN	alkB, alkylation repair homolog 2 (E. coli)	46					DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(3)|large_intestine(1)|lung(3)	8					Vitamin C(DB00126)	TCCATTCCCTGGGGCCTCTCT	0.582000								Direct reversal of damage					20	114					0	0	0.00121646	0	0
COBL	23242	broad.mit.edu	37	7	51095552	51095552	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:51095552C>T	ENST00000395542.2	-	12	3671	c.3487G>A	c.(3487-3489)Gac>Aac	p.D1163N	COBL_ENST00000265136.7_Missense_Mutation_p.D1081N			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	1081	WH2 2.									NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					CAAATACTGTCTGTTTCATTT	0.498000													11	90					0	0	0.00136819	0	0
ROR1	4919	broad.mit.edu	37	1	64643408	64643408	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:64643408G>A	ENST00000371079.1	+	9	2059	c.1684G>A	c.(1684-1686)Gag>Aag	p.E562K	ROR1_ENST00000545203.1_Missense_Mutation_p.E13K	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	562	Protein kinase.		E -> D (in a breast cancer sample; somatic mutation).		transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						GGATCTCCATGAGTTCCTCAT	0.488000													12	69					0	0	0.000978159	0	0
HAVCR1	26762	broad.mit.edu	37	5	156459882	156459882	+	Splice_Site	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:156459882C>T	ENST00000517644.1	-	4	283		c.e4-1		HAVCR1_ENST00000339252.3_Silent_p.K323K|HAVCR1_ENST00000425854.1_Intron|HAVCR1_ENST00000522693.1_Intron|HAVCR1_ENST00000544197.1_Silent_p.K323K|HAVCR1_ENST00000523175.1_Silent_p.K323K			Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1						interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTTGAACCTCCTTTTTGAAGA	0.338000													40	221					0	0	0.000781405	0	0
SLC12A7	10723	broad.mit.edu	37	5	1060544	1060544	+	Missense_Mutation	SNP	A	A	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:1060544A>T	ENST00000264930.5	-	21	2805	c.2762T>A	c.(2761-2763)tTc>tAc	p.F921Y		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	921					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CTCGTAGGTGAAAGCAGATAT	0.552000													7	58					0	0	0.000157383	0	0
CSRP2BP	57325	broad.mit.edu	37	20	18143107	18143107	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr20:18143107G>A	ENST00000278816.2	+	7	1839	c.1189G>A	c.(1189-1191)Gtg>Atg	p.V397M	CSRP2BP_ENST00000489634.2_Missense_Mutation_p.V269M|CSRP2BP_ENST00000435364.2_Missense_Mutation_p.V397M|CSRP2BP_ENST00000377681.2_Missense_Mutation_p.V396M			Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	397					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|stomach(1)	34						TTCTGGGCCAGTGGTTGGGGT	0.532000													5	17					0	0	0.000602214	0	0
BRWD3	254065	broad.mit.edu	37	X	79999689	79999689	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chrX:79999689G>A	ENST00000373275.4	-	8	871	c.655C>T	c.(655-657)Cgt>Tgt	p.R219C		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	219								p.R219C(1)		breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						GAGTGTCCACGAAGTGTAGCA	0.403000													11	36					0	0	0.00185496	0	0
UBASH3A	53347	broad.mit.edu	37	21	43857599	43857599	+	Splice_Site	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr21:43857599G>A	ENST00000319294.6	+	11	1426	c.1393_splice	c.e11-1	p.G465_splice	UBASH3A_ENST00000291535.6_Splice_Site_p.G427_splice|UBASH3A_ENST00000398367.1_Splice_Site_p.G427_splice	NM_018961.3	NP_061834.1	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing A	465	Phosphatase-like.					cytosol|nucleus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(9)|lung(12)|ovary(3)	28						ATTTTCCAGGGGACGCGCTAC	0.537000													9	44					0	0	0.000442599	0	0
SLC35F3	148641	broad.mit.edu	37	1	234452397	234452397	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:234452397C>T	ENST00000366618.3	+	5	1023	c.878C>T	c.(877-879)gCt>gTt	p.A293V	SLC35F3_ENST00000366617.3_Missense_Mutation_p.A224V	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	224					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			ATGACCTACGCTGATGGCTTC	0.582000													26	172					0	0	0.00047179	0	0
FPR1	2357	broad.mit.edu	37	19	52249918	52249918	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:52249918G>A	ENST00000595042.1	-	3	471	c.330C>T	c.(328-330)ttC>ttT	p.F110F	FPR1_ENST00000304748.4_Silent_p.F110F	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	110					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	AGACACTTCCGAACAAGTTGA	0.542000													7	60					0	0	0.000157383	0	0
CATSPERB	79820	broad.mit.edu	37	14	92159768	92159768	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:92159768C>T	ENST00000256343.3	-	8	828	c.672G>A	c.(670-672)tgG>tgA	p.W224*		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	224					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TCATGTTAAACCATGTGGTAT	0.353000													9	64					0	0	0.000673444	0	0
FAM209A	200232	broad.mit.edu	37	20	55100954	55100954	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr20:55100954C>T	ENST00000371328.3	+	2	667	c.344C>T	c.(343-345)aCc>aTc	p.T115I	GCNT7_ENST00000243913.4_5'UTR|FAM209A_ENST00000481560.1_3'UTR	NM_001012971.3	NP_001012989.2			family with sequence similarity 209, member A																		GCATTCAATACCTTAATGGAA	0.473000													7	78					0	0	0.000157383	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33751639	33751639	+	Silent	SNP	T	T	C			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:33751639T>C	ENST00000504830.1	-	3	839	c.504A>G	c.(502-504)caA>caG	p.Q168Q	ADAMTS12_ENST00000352040.3_Silent_p.Q168Q|ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000515401.1_Silent_p.Q168Q	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	168					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CATGTGGTAGTTGGAAAAATC	0.383000										HNSCC(64;0.19)			8	88					0	0	0.000157383	0	0
ZNF331	55422	broad.mit.edu	37	19	54080048	54080048	+	Silent	SNP	C	C	T	rs141196058		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:54080048C>T	ENST00000253144.9	+	7	1567	c.234C>T	c.(232-234)tcC>tcT	p.S78S	ZNF331_ENST00000449416.1_Silent_p.S78S|ZNF331_ENST00000411977.2_Silent_p.S78S|ZNF331_ENST00000513999.1_Silent_p.S78S|ZNF331_ENST00000512387.1_Silent_p.S78S|ZNF331_ENST00000511593.2_Silent_p.S78S|ZNF331_ENST00000511154.1_Silent_p.S78S|ZNF331_ENST00000513265.1_Silent_p.S78S	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	78	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S78S(1)		NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		GAAGTAAATCCCTTGGCCGTA	0.393000			T	?	follicular thyroid adenoma								7	75					0	0	8.12818e-05	0	0
MUC16	94025	broad.mit.edu	37	19	9088334	9088334	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:9088334G>A	ENST00000397910.4	-	1	3684	c.3481C>T	c.(3481-3483)Cct>Tct	p.P1161S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1161	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTGGGAGTAGGAGAAGAAGGA	0.488000													12	68					0	0	0.000219431	0	0
UBAC2	337867	broad.mit.edu	37	13	100020040	100020040	+	Splice_Site	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr13:100020040G>A	ENST00000376440.2	+	6	1205		c.e6-1		UBAC2_ENST00000460562.1_Splice_Site|UBAC2_ENST00000403766.3_Splice_Site	NM_177967.3	NP_808882.1	Q8NBM4	UBAC2_HUMAN	UBA domain containing 2							integral to membrane				breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)	10	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TCTCTTTTTAGGGAGGAATGA	0.463000													9	73					0	0	0.000274275	0	0
CEACAM5	1048	broad.mit.edu	37	19	42231208	42231208	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:42231208G>A	ENST00000221992.6	+	9	2195	c.2081G>A	c.(2080-2082)gGa>gAa	p.G694E	CEACAM5_ENST00000405816.1_Missense_Mutation_p.G694E|CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000398599.4_Missense_Mutation_p.G693E	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	694						anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		ATCATGATTGGAGTGCTGGTT	0.478000													45	308					0	0	0.000781405	0	0
PTCD2	79810	broad.mit.edu	37	5	71618054	71618054	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:71618054G>A	ENST00000380639.5	+	2	199	c.183G>A	c.(181-183)aaG>aaA	p.K61K	PTCD2_ENST00000543322.1_Silent_p.K61K|PTCD2_ENST00000536805.1_5'UTR|PTCD2_ENST00000503868.1_Silent_p.K61K	NM_024754.3	NP_079030.3	Q8WV60	PTCD2_HUMAN	pentatricopeptide repeat domain 2	61										breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(1)|skin(1)	11		Lung NSC(167;0.00237)|Ovarian(174;0.0175)|Prostate(461;0.141)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.73e-53)		TTCAACAAAAGAAAGTGGCTG	0.284000													27	182					0	0	0.00178596	0	0
ATP13A4	84239	broad.mit.edu	37	3	193120522	193120522	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:193120522G>A	ENST00000342695.4	-	30	3832	c.3510C>T	c.(3508-3510)acC>acT	p.T1170T	ATP13A4_ENST00000392443.3_Silent_p.T1151T|ATP13A4_ENST00000400270.2_Silent_p.T186T|ATP13A4_ENST00000482964.1_5'UTR	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	1170					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		CAGAGTGGGAGGTTTGGTTTA	0.468000													6	49					0	0	0.00116845	0	0
RYR2	6262	broad.mit.edu	37	1	237936894	237936894	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:237936894C>T	ENST00000366574.2	+	87	12038	c.11721C>T	c.(11719-11721)tcC>tcT	p.S3907S	RYR2_ENST00000360064.6_Silent_p.S3913S|RYR2_ENST00000542537.1_Silent_p.S3891S	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3907					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGAATTTCTCCAAAGCTATCC	0.348000													4	49					0	0	0.000602214	0	0
APOA4	337	broad.mit.edu	37	11	116691864	116691864	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:116691864G>A	ENST00000357780.3	-	3	1024	c.910C>T	c.(910-912)Cga>Tga	p.R304*		NM_000482.3	NP_000473.2			apolipoprotein A-IV											cervix(1)|endometrium(2)|lung(10)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		ACCCGGCGTCGGAACTCCTCC	0.652000													37	260					0	0	0.00170553	0	0
MYCBP2	23077	broad.mit.edu	37	13	77672557	77672557	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr13:77672557G>A	ENST00000407578.2	-	56	8998	c.8732C>T	c.(8731-8733)tCc>tTc	p.S2911F	MYCBP2-AS1_ENST00000593933.1_RNA|MYCBP2_ENST00000360084.5_Missense_Mutation_p.S396F|MYCBP2_ENST00000357337.6_Missense_Mutation_p.S2873F|MYCBP2_ENST00000482517.1_5'UTR|MYCBP2_ENST00000544440.2_Missense_Mutation_p.S2873F	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	2873					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AGATCCAGGGGAATCTGTAGA	0.468000													7	56					0	0	8.12818e-05	0	0
EPRS	2058	broad.mit.edu	37	1	220156683	220156683	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:220156683G>A	ENST00000366923.3	-	22	3417	c.3148C>T	c.(3148-3150)Cgt>Tgt	p.R1050C		NM_004446.2	NP_004437.2	P07814	SYEP_HUMAN	glutamyl-prolyl-tRNA synthetase	1050	Prolyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			breast(2)|endometrium(11)|kidney(2)|large_intestine(13)|lung(24)|ovary(1)|prostate(3)|skin(2)|stomach(2)|urinary_tract(3)	63				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	GCCCAGGGACGAAGAATATAA	0.378000													5	49					0	0	8.12818e-05	0	0
HERC5	51191	broad.mit.edu	37	4	89415451	89415451	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:89415451G>A	ENST00000264350.3	+	18	2566	c.2413G>A	c.(2413-2415)Gac>Aac	p.D805N	HERC5_ENST00000508159.1_Missense_Mutation_p.D443N	NM_016323.3	NP_057407.2	Q9UII4	HERC5_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 5	805	HECT.				innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			NS(2)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|liver(2)|lung(17)|ovary(4)|prostate(1)|skin(4)	53		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		ATCATTGGAAGACTTGAAAGA	0.393000													5	37					0	0	0.000602214	0	0
NCOA1	8648	broad.mit.edu	37	2	24991212	24991212	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:24991212C>T	ENST00000406961.1	+	23	4930	c.4278C>T	c.(4276-4278)acC>acT	p.T1426T	NCOA1_ENST00000405141.1_3'UTR|NCOA1_ENST00000348332.3_Silent_p.T1426T|NCOA1_ENST00000288599.5_3'UTR|NCOA1_ENST00000407230.1_3'UTR|NCOA1_ENST00000395856.3_Silent_p.T1425T			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	1426									PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GACCACAGACCCCCCAGGCCC	0.488000			T	PAX3	alveolar rhadomyosarcoma								7	43					0	0	0.000274275	0	0
FAM220A	84792	broad.mit.edu	37	7	6370297	6370297	+	Missense_Mutation	SNP	T	T	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:6370297T>A	ENST00000313324.4	-	2	956	c.489A>T	c.(487-489)gaA>gaT	p.E163D		NM_001037163.1	NP_001032240.1	Q7Z4H9	SIPAR_HUMAN	family with sequence similarity 220, member A	163						nucleus											AACTTCCCATTTCCGGCACTT	0.607000													5	42					0	0	0.000602214	0	0
TTC7A	57217	broad.mit.edu	37	2	47287978	47287978	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:47287978C>T	ENST00000319190.5	+	19	2591	c.2223C>T	c.(2221-2223)ttC>ttT	p.F741F	TTC7A_ENST00000263737.6_Silent_p.F387F|TTC7A_ENST00000394850.2_Silent_p.F765F|TTC7A_ENST00000409245.1_Silent_p.F707F	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	741							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			CGGGCCTCTTCCCCACTTCTC	0.602000													13	59					0	0	0.000422831	0	0
SCN9A	6335	broad.mit.edu	37	2	167140996	167140996	+	Splice_Site	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:167140996C>T	ENST00000409672.1	-	12	2287	c.1941_splice	c.e12+1	p.E647_splice	SCN9A_ENST00000409435.1_Silent_p.E647E|AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000303354.6_Silent_p.E648E|SCN9A_ENST00000375387.4_Silent_p.E648E	NM_002977.3	NP_002968.1	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	647						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	CTATTATCACCTCTGGCAGAA	0.527000													4	17					0	0	0.00024832	0	0
CRX	1406	broad.mit.edu	37	19	48339542	48339542	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:48339542G>A	ENST00000221996.7	+	3	349	c.143G>A	c.(142-144)cGg>cAg	p.R48Q	TPRX2P_ENST00000535362.1_Intron|CRX_ENST00000539067.1_Missense_Mutation_p.R48Q	NM_000554.4	NP_000545.1	O43186	CRX_HUMAN	cone-rod homeobox	48					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|urinary_tract(1)	23		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		ACCTTCACCCGGAGCCAACTG	0.637000													10	35					0	0	0.000442599	0	0
STAC	6769	broad.mit.edu	37	3	36527639	36527639	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:36527639G>A	ENST00000273183.3	+	5	885	c.585G>A	c.(583-585)aaG>aaA	p.K195K	STAC_ENST00000457375.2_Silent_p.K134K|STAC_ENST00000476388.1_3'UTR	NM_003149.1	NP_003140.1	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	195					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			endometrium(5)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(5)	32						GTGGCAATAAGGTGGACCCTG	0.582000													18	131					0	0	0.000295444	0	0
BTNL8	79908	broad.mit.edu	37	5	180335744	180335744	+	Missense_Mutation	SNP	G	G	A	rs139672035		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:180335744G>A	ENST00000231229.4	+	2	442	c.208G>A	c.(208-210)Ggg>Agg	p.G70R	BTNL8_ENST00000508408.1_Missense_Mutation_p.G70R|BTNL8_ENST00000511704.1_Intron|BTNL8_ENST00000400707.3_Intron|BTNL8_ENST00000340184.4_Missense_Mutation_p.G70R	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	70	Ig-like V-type 1.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTACAGGGACGGGAAGGACCA	0.532000													19	158					0	0	0.00152264	0	0
NOTCH2NL	388677	broad.mit.edu	37	1	145273351	145273351	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:145273351C>T	ENST00000369340.3	+	4	649	c.205C>T	c.(205-207)Cca>Tca	p.P69S	NOTCH2NL_ENST00000344859.3_Missense_Mutation_p.P69S|NOTCH2NL_ENST00000362074.6_Missense_Mutation_p.P69S|RP11-458D21.5_ENST00000468030.1_Missense_Mutation_p.P69S			Q7Z3S9	NT2NL_HUMAN	notch 2 N-terminal like	69	EGF-like 3.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	27						GACATCTCATCCATGCTTTGT	0.552000													45	1164					0	0	0.00128727	0	0
NFATC3	4775	broad.mit.edu	37	16	68224858	68224858	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr16:68224858C>T	ENST00000349223.5	+	9	2510	c.2286C>T	c.(2284-2286)tcC>tcT	p.S762S	NFATC3_ENST00000575270.1_Silent_p.S762S|NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000346183.3_Silent_p.S762S|NFATC3_ENST00000329524.4_Silent_p.S762S	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	762					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		TGACCTCATCCCATCTGCCAC	0.448000													7	47					0	0	8.12818e-05	0	0
PRRC2A	7916	broad.mit.edu	37	6	31596977	31596977	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:31596977C>T	ENST00000376033.2	+	13	2056	c.1822C>T	c.(1822-1824)Cct>Tct	p.P608S	PRRC2A_ENST00000376007.4_Missense_Mutation_p.P608S	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	608	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						GGTTCCTCCTCCTACCACACC	0.537000													7	83					0	0	8.12818e-05	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12855615	12855615	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:12855615G>A	ENST00000332296.7	+	4	998	c.895G>A	c.(895-897)Gaa>Aaa	p.E299K	PRAMEF1_ENST00000400814.3_Missense_Mutation_p.E54K	NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	299										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGAGAACTTGGAATTAACTTA	0.463000													11	87					0	0	0.000978159	0	0
ZSCAN31	64288	broad.mit.edu	37	6	28294165	28294165	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:28294165G>A	ENST00000414429.1	-	8	1902	c.999C>T	c.(997-999)ctC>ctT	p.L333L	ZSCAN31_ENST00000439158.1_Silent_p.L333L|ZSCAN31_ENST00000344279.6_Silent_p.L333L|ZSCAN31_ENST00000446474.1_Silent_p.L174L|ZSCAN31_ENST00000396838.2_Silent_p.L333L|ZSCAN31_ENST00000481934.1_5'UTR					zinc finger and SCAN domain containing 31																		ATGAGCTGAGGAGGAAAGCCT	0.502000													20	184					0	0	0.000295444	0	0
OR2A14	135941	broad.mit.edu	37	7	143826686	143826686	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:143826686C>T	ENST00000408899.2	+	1	536	c.481C>T	c.(481-483)Ctc>Ttc	p.L161F		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					CCCTTTAGTTCTCATCCTGAG	0.542000													24	213					0	0	0.00106085	0	0
ARRDC1	92714	broad.mit.edu	37	9	140508859	140508859	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr9:140508859C>T	ENST00000371421.4	+	6	791	c.727C>T	c.(727-729)Ctg>Ttg	p.L243L	ARRDC1_ENST00000491911.1_3'UTR	NM_152285.2	NP_689498.1	Q8N5I2	ARRD1_HUMAN	arrestin domain containing 1	243										breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|urinary_tract(1)	13	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000273)|Epithelial(140;0.000464)		CGAGCAGATCCTGGTGCCTGC	0.657000													11	69					0	0	0.000978159	0	0
RRP12	23223	broad.mit.edu	37	10	99139485	99139485	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr10:99139485G>A	ENST00000370992.4	-	14	1687	c.1576C>T	c.(1576-1578)Ccc>Tcc	p.P526S	RRP12_ENST00000536831.1_Missense_Mutation_p.P244S|RRP12_ENST00000315563.6_Missense_Mutation_p.P426S|RRP12_ENST00000414986.1_Missense_Mutation_p.P465S	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	526						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		GCCGTGTGGGGGAAATGAGGG	0.597000													8	32					0	0	0.000442599	0	0
GABRA2	2555	broad.mit.edu	37	4	46312230	46312230	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:46312230G>A	ENST00000510861.1	-	6	692	c.519C>T	c.(517-519)ttC>ttT	p.F173F	GABRA2_ENST00000514090.1_Silent_p.F173F|GABRA2_ENST00000540012.1_Silent_p.F118F|GABRA2_ENST00000356504.1_Silent_p.F173F|GABRA2_ENST00000381620.4_Silent_p.F173F|GABRA2_ENST00000507069.1_Silent_p.F173F|GABRA2_ENST00000515082.1_Silent_p.F173F			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	173					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CATCCATTGGGAAATCCTCCA	0.378000													9	72					0	0	0.000673444	0	0
CDH4	1002	broad.mit.edu	37	20	60485526	60485526	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr20:60485526C>T	ENST00000360469.5	+	9	1325	c.1237C>T	c.(1237-1239)Ctc>Ttc	p.L413F	CDH4_ENST00000543233.1_Missense_Mutation_p.L339F	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	413	Cadherin 3.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GGTCGCAAACCTCACGGTGAT	0.542000													4	31					0	0	0.00024832	0	0
DRGX	644168	broad.mit.edu	37	10	50574314	50574314	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr10:50574314G>A	ENST00000374139.2	-	6	649	c.639C>T	c.(637-639)gcC>gcT	p.A213A	DRGX_ENST00000434016.1_Silent_p.A218A			C9JW76	C9JW76_HUMAN	dorsal root ganglia homeobox	218					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	11						AGTGCTCGCGGGCCTTCATGC	0.677000													8	73					0	0	0.000442599	0	0
LY9	4063	broad.mit.edu	37	1	160783651	160783651	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:160783651C>T	ENST00000263285.5	+	3	710	c.680C>T	c.(679-681)cCc>cTc	p.P227L	LY9_ENST00000341032.4_Missense_Mutation_p.P227L|LY9_ENST00000368041.2_Missense_Mutation_p.P187L|LY9_ENST00000471816.1_3'UTR|LY9_ENST00000368040.1_5'UTR	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	227	Ig-like C2-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			GCCCAGAACCCCGTCAGCCAG	0.547000													6	115					0	0	0.000157383	0	0
NOX3	50508	broad.mit.edu	37	6	155774583	155774583	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:155774583G>A	ENST00000159060.2	-	4	397	c.295C>T	c.(295-297)Ctc>Ttc	p.L99F		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	99	Ferric oxidoreductase.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		TGAAATCTGAGGTTTTTGTCT	0.368000													27	271					0	0	0.00127121	0	0
OR5H1	26341	broad.mit.edu	37	3	97851872	97851872	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:97851872G>A	ENST00000354565.2	+	1	331	c.331G>A	c.(331-333)Gaa>Aaa	p.E111K	RP11-343D2.11_ENST00000508964.1_RNA	NM_001005338.1	NP_001005338.1	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H, member 1	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						TGTAACCACGGAATGTTTTCT	0.408000													16	163					0	0	0.00074312	0	0
GIN1	54826	broad.mit.edu	37	5	102432371	102432371	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:102432371G>A	ENST00000399004.2	-	7	1262	c.1168C>T	c.(1168-1170)Cct>Tct	p.P390S	GIN1_ENST00000508629.1_Intron	NM_017676.2	NP_060146.2	Q9NXP7	GIN1_HUMAN	gypsy retrotransposon integrase 1	390					DNA integration		DNA binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		ATGACACAAGGACCAACCCAT	0.393000													19	145					0	0	0.000586117	0	0
TTN	7273	broad.mit.edu	37	2	179597660	179597660	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:179597660C>T	ENST00000589042.1	-	55	16467	c.16243G>A	c.(16243-16245)Gag>Aag	p.E5415K	TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.E5098K|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.E4171K|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5098	Ig-like 35.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGATGATCTCCAAAGAGGCT	0.493000													6	34					0	0	8.12818e-05	0	0
UGP2	7360	broad.mit.edu	37	2	64085050	64085050	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:64085050C>T	ENST00000337130.5	+	3	711	c.235C>T	c.(235-237)Cag>Tag	p.Q79*	UGP2_ENST00000487469.1_Intron|UGP2_ENST00000467648.2_Nonsense_Mutation_p.Q68*|UGP2_ENST00000445915.2_Nonsense_Mutation_p.Q88*|UGP2_ENST00000394417.2_Nonsense_Mutation_p.Q68*	NM_006759.3	NP_006750.3	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2	79					glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)	18						GGGAAAAATCCAGAGACCCCC	0.413000													9	189					0	0	0.000274275	0	0
ZNF536	9745	broad.mit.edu	37	19	31039066	31039066	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:31039066G>A	ENST00000355537.3	+	4	2687	c.2540G>A	c.(2539-2541)gGa>gAa	p.G847E		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	847					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGTCTCCCTGGAATCGACTTC	0.577000													5	68					0	0	0.00116845	0	0
ZNF292	23036	broad.mit.edu	37	6	87969747	87969747	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:87969747C>T	ENST00000369577.3	+	8	6443	c.6400C>T	c.(6400-6402)Cat>Tat	p.H2134Y	ZNF292_ENST00000339907.4_Missense_Mutation_p.H2129Y	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	2134					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		CTTGATTCTCCATTACCAGGC	0.418000													14	68					0	0	0.000219431	0	0
MUC17	140453	broad.mit.edu	37	7	100679055	100679055	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:100679055G>A	ENST00000306151.4	+	3	4422	c.4358G>A	c.(4357-4359)gGa>gAa	p.G1453E		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1453	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTAGTGAAGGAAAGACTCCA	0.498000													25	173					0	0	0.00047179	0	0
MUC16	94025	broad.mit.edu	37	19	9083281	9083281	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:9083281G>A	ENST00000397910.4	-	1	8737	c.8534C>T	c.(8533-8535)cCc>cTc	p.P2845L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2845	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TATCCCTTTGGGTGCTGTTGA	0.507000													4	18					0	0	0.00024832	0	0
OR8B12	219858	broad.mit.edu	37	11	124413287	124413287	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:124413287C>T	ENST00000306842.2	-	1	288	c.264G>A	c.(262-264)aaG>aaA	p.K88K		NM_001005195.1	NP_001005195.1	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B, member 12	88					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		AAATGATGTTCTTCCTTGAGA	0.433000													7	64					0	0	0.000157383	0	0
MFSD5	84975	broad.mit.edu	37	12	53647900	53647900	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:53647900C>T	ENST00000534842.1	+	2	1749	c.1602C>T	c.(1600-1602)ttC>ttT	p.F534F	MFSD5_ENST00000329548.4_Silent_p.F427F	NM_001170790.1	NP_001164261.1	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing 5	427					transport	integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|skin(3)|urinary_tract(1)	16						TGGGACTCTTCACCGTGGTAA	0.542000													9	56					0	0	0.000442599	0	0
BRINP1	1620	broad.mit.edu	37	9	121929766	121929766	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr9:121929766G>A	ENST00000265922.3	-	8	2343	c.1882C>T	c.(1882-1884)Cta>Tta	p.L628L	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		628					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						TTTCGCAGTAGGGTAGGTAGC	0.537000													16	99					0	0	0.000422831	0	0
SULF2	55959	broad.mit.edu	37	20	46295078	46295078	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr20:46295078C>T	ENST00000359930.4	-	12	2582	c.1731G>A	c.(1729-1731)aaG>aaA	p.K577K	SULF2_ENST00000467815.1_Silent_p.K577K|SULF2_ENST00000361612.4_Silent_p.K577K|SULF2_ENST00000484875.1_Silent_p.K577K	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	577					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						CCCCACCATCCTTGTCATCTT	0.627000													8	59					0	0	0.000157383	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106558458	106558458	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:106558458G>A	ENST00000526355.1	-	8	2484	c.2016C>T	c.(2014-2016)ttC>ttT	p.F672F	GUCY1A2_ENST00000347596.2_Silent_p.F693F|GUCY1A2_ENST00000282249.2_Silent_p.F703F	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	672					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GAATGAATGTGAAACTTTCTT	0.408000													23	110					0	0	0.000586117	0	0
ADRA1A	148	broad.mit.edu	37	8	26628003	26628003	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:26628003G>A	ENST00000380573.3	-	3	2087	c.1064C>T	c.(1063-1065)gCc>gTc	p.A355V	ADRA1A_ENST00000380586.1_Missense_Mutation_p.A355V|ADRA1A_ENST00000519229.1_Missense_Mutation_p.A355V|ADRA1A_ENST00000380581.2_Intron|ADRA1A_ENST00000380582.3_Missense_Mutation_p.A355V|ADRA1A_ENST00000380587.1_Intron|ADRA1A_ENST00000276393.4_Missense_Mutation_p.A355V|ADRA1A_ENST00000354550.4_Missense_Mutation_p.A355V			P35348	ADA1A_HUMAN	adrenoceptor alpha 1A	355					activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|skin(1)	36		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	GTAGCCCAGGGCATGTTTGGA	0.542000													23	145					0	0	0.00047179	0	0
PIWIL4	143689	broad.mit.edu	37	11	94353025	94353025	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:94353025G>A	ENST00000299001.6	+	18	2479	c.2268G>A	c.(2266-2268)gtG>gtA	p.V756V	PIWIL4_ENST00000537419.1_Silent_p.V107V|RP11-867G2.8_ENST00000536540.1_RNA|RP11-867G2.8_ENST00000537874.1_RNA	NM_152431.2	NP_689644.2	Q7Z3Z4	PIWL4_HUMAN	piwi-like RNA-mediated gene silencing 4	756	Piwi.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|urinary_tract(2)	30		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GCACTGTTGTGGATTCAGAAG	0.443000													11	63					0	0	0.000978159	0	0
ATP8A2	51761	broad.mit.edu	37	13	26152961	26152961	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr13:26152961G>A	ENST00000381655.2	+	21	1933	c.1791G>A	c.(1789-1791)gtG>gtA	p.V597V	ATP8A2_ENST00000255283.8_Silent_p.V557V|ATP8A2_ENST00000491840.1_3'UTR	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	557					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		AGGATAATGTGATTTTTGAGA	0.373000													5	32					0	0	0.00116845	0	0
GRIK5	2901	broad.mit.edu	37	19	42558499	42558499	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:42558499C>T	ENST00000262895.3	-	8	1028	c.1029G>A	c.(1027-1029)ggG>ggA	p.G343G	GRIK5_ENST00000593562.1_Silent_p.G343G|GRIK5_ENST00000301218.4_Silent_p.G343G	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	343						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	TGAGGCTGGTCCCGTGGGGCC	0.652000													10	55					0	0	0.000673444	0	0
CENPN	55839	broad.mit.edu	37	16	81045558	81045558	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr16:81045558T>C	ENST00000305850.5	+	2	804	c.14T>C	c.(13-15)gTt>gCt	p.V5A	CENPN_ENST00000569461.1_3'UTR|CMC2_ENST00000565914.1_Intron|CENPN_ENST00000439957.3_Missense_Mutation_p.V5A|CENPN_ENST00000428963.2_Missense_Mutation_p.V5A|CENPN_ENST00000393335.3_Missense_Mutation_p.V5A|CENPN_ENST00000299572.5_Missense_Mutation_p.V5A	NM_001100624.2|NM_001270474.1	NP_001094094.2|NP_001257403.1	Q96H22	CENPN_HUMAN	centromere protein N	5					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm				breast(1)|large_intestine(5)|lung(4)	10						GATGAGACTGTTGCTGAGTTC	0.368000													4	29					0	0	0.00116845	0	0
ILDR1	286676	broad.mit.edu	37	3	121712760	121712760	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:121712760G>A	ENST00000273691.3	-	6	809	c.704C>T	c.(703-705)cCt>cTt	p.P235L	ILDR1_ENST00000460554.1_5'UTR|ILDR1_ENST00000462014.1_Missense_Mutation_p.P247L|ILDR1_ENST00000393631.1_Missense_Mutation_p.P190L|ILDR1_ENST00000344209.5_Missense_Mutation_p.P279L	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	279						cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		GGCGATGGGAGGCTGATTGGT	0.542000													4	47					0	0	0.00116845	0	0
UNC79	57578	broad.mit.edu	37	14	93954060	93954060	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:93954060C>T	ENST00000553484.1	+	5	825	c.671C>T	c.(670-672)tCa>tTa	p.S224L	UNC79_ENST00000393151.2_Missense_Mutation_p.S224L|UNC79_ENST00000256339.4_Missense_Mutation_p.S47L|UNC79_ENST00000555664.1_Missense_Mutation_p.S224L			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	224						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CTCTCTGCATCATCCATGCTA	0.388000													13	111					0	0	0.000308642	0	0
TMEM43	79188	broad.mit.edu	37	3	14176677	14176677	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:14176677C>T	ENST00000306077.4	+	9	979	c.725C>T	c.(724-726)tCc>tTc	p.S242F		NM_024334.2	NP_077310.1	Q9BTV4	TMM43_HUMAN	transmembrane protein 43	242						endoplasmic reticulum|Golgi apparatus|integral to membrane|nuclear inner membrane				breast(1)|cervix(3)|endometrium(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(2)	19						TTGCGTGTCTCCTTTTCCTAT	0.627000													4	19					0	0	0.000602214	0	0
FASTKD5	60493	broad.mit.edu	37	20	3127538	3127538	+	Missense_Mutation	SNP	G	G	A	rs114422732	by1000genomes	TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr20:3127538G>A	ENST00000380266.3	-	2	2500	c.2179C>T	c.(2179-2181)Cgg>Tgg	p.R727W	UBOX5-AS1_ENST00000446537.1_RNA|UBOX5_ENST00000217173.2_Intron|UBOX5_ENST00000348031.2_Intron	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	727	RAP.				apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						TAGCCAAGCCGAGCCAGCTGC	0.483000													17	70					0	0	0.000422831	0	0
TRBV5-5	28610	broad.mit.edu	37	7	142149026	142149026	+	RNA	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:142149026C>T	ENST00000390372.3	-	0	251																											AGCTGAGAATCGATCAGGGAA	0.517000													9	64					0	0	0.000274275	0	0
CAMK1	8536	broad.mit.edu	37	3	9799255	9799255	+	Missense_Mutation	SNP	C	C	T	rs56033923	by1000genomes	TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:9799255C>T	ENST00000256460.3	-	12	1258	c.1081G>A	c.(1081-1083)Gaa>Aaa	p.E361K	OGG1_ENST00000302008.8_Intron|OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302036.7_Intron|OGG1_ENST00000349503.5_Intron|OGG1_ENST00000449570.2_Intron	NM_003656.4	NP_003647.1	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	361			E -> K (in dbSNP:rs56033923).		cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	12	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		GGGGACAGTTCTGTGCCCGGC	0.682000													8	33					0	0	0.000442599	0	0
ABCC4	10257	broad.mit.edu	37	13	95858972	95858972	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr13:95858972G>A	ENST00000376887.4	-	8	1089	c.975C>T	c.(973-975)ttC>ttT	p.F325F	ABCC4_ENST00000412704.1_Silent_p.F325F|ABCC4_ENST00000538287.1_3'UTR|ABCC4_ENST00000536256.1_Silent_p.F250F|ABCC4_ENST00000431522.1_Silent_p.F325F	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	325	ABC transmembrane type-1 1.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	TGCTTGCACTGAAAAATGAAG	0.473000													17	163					0	0	0.00074312	0	0
CHD5	26038	broad.mit.edu	37	1	6202348	6202348	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:6202348G>A	ENST00000262450.3	-	15	2375	c.2276C>T	c.(2275-2277)tCc>tTc	p.S759F	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	759	Helicase ATP-binding.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GATGATGGTGGAGAGGGGCGC	0.642000													7	43					0	0	0.000157383	0	0
FER1L6	654463	broad.mit.edu	37	8	125082714	125082714	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:125082714G>A	ENST00000522917.1	+	30	4047	c.3841G>A	c.(3841-3843)Gac>Aac	p.D1281N	FER1L6_ENST00000399018.1_Missense_Mutation_p.D1281N|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1281						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAAGATATATGACGGTGATCT	0.418000													10	111					0	0	0.00185496	0	0
MYSM1	114803	broad.mit.edu	37	1	59139288	59139288	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:59139288C>T	ENST00000472487.1	-	11	1568	c.1529G>A	c.(1528-1530)gGa>gAa	p.G510E	MYSM1_ENST00000493821.1_5'UTR	NM_001085487.2	NP_001078956.1	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	510					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(7;9.36e-06)					ACACCAGTTTCCCCATGGGTC	0.383000													6	50					0	0	0.000157383	0	0
OR5D16	390144	broad.mit.edu	37	11	55606700	55606700	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:55606700C>T	ENST00000378396.1	+	1	473	c.473C>T	c.(472-474)tCc>tTc	p.S158F		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	158					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S158F(1)		cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				GTCGCATGTTCCCTGACACTC	0.448000													7	47					0	0	8.12818e-05	0	0
FAM129A	116496	broad.mit.edu	37	1	184792371	184792371	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:184792371C>T	ENST00000367511.3	-	8	1108	c.915G>A	c.(913-915)ctG>ctA	p.L305L	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	305					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						TCGTTCCTTCCAGGCCCTTTG	0.448000													13	52					0	0	0.00185496	0	0
TRIM55	84675	broad.mit.edu	37	8	67066485	67066485	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:67066485G>A	ENST00000315962.4	+	9	1813	c.1440G>A	c.(1438-1440)cgG>cgA	p.R480R	TRIM55_ENST00000276573.7_Silent_p.R480R|TRIM55_ENST00000353317.5_Intron|TRIM55_ENST00000350034.4_Intron	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	480						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			CGAATGTACGGAAGGCAGAAG	0.572000													5	36					0	0	0.000157383	0	0
ASB7	140460	broad.mit.edu	37	15	101169997	101169997	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr15:101169997C>T	ENST00000332783.7	+	5	1352	c.567C>T	c.(565-567)atC>atT	p.I189I	ASB7_ENST00000558747.1_Intron|ASB7_ENST00000343276.4_Silent_p.I189I	NM_198243.2	NP_937886.1	Q9H672	ASB7_HUMAN	ankyrin repeat and SOCS box containing 7	189					intracellular signal transduction					breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(2)	16	Lung NSC(78;0.00121)|all_lung(78;0.00152)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00168)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			ACGCCGTGATCAAAAGCAATC	0.483000													5	32					0	0	0.00116845	0	0
CYB5R4	51167	broad.mit.edu	37	6	84627781	84627781	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:84627781C>T	ENST00000369681.4	+	6	643	c.503C>T	c.(502-504)cCa>cTa	p.P168L		NM_016230.3	NP_057314.2	Q7L1T6	NB5R4_HUMAN	cytochrome b5 reductase 4	168	CS.				cell development|detection of oxygen|generation of precursor metabolites and energy|glucose homeostasis|insulin secretion|response to antibiotic|superoxide metabolic process	endoplasmic reticulum|perinuclear region of cytoplasm	cytochrome-b5 reductase activity|heme binding|NAD(P)H oxidase activity	p.P168>?(1)		breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	23		all_cancers(76;7e-07)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00128)		BRCA - Breast invasive adenocarcinoma(397;0.0871)		CCTAGTTATCCAAGGTATGCA	0.303000													9	82					0	0	0.000442599	0	0
NOX3	50508	broad.mit.edu	37	6	155774584	155774584	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:155774584G>A	ENST00000159060.2	-	4	396	c.294C>T	c.(292-294)aaC>aaT	p.N98N		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	98	Ferric oxidoreductase.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		GAAATCTGAGGTTTTTGTCTA	0.368000													26	269					0	0	0.00106085	0	0
OR5H2	79310	broad.mit.edu	37	3	98002486	98002486	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:98002486C>T	ENST00000355273.2	+	1	755	c.755C>T	c.(754-756)tCt>tTt	p.S252F	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	252					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						CATCTCTTATCTGTCTCTTTA	0.393000													8	46					0	0	0.000442599	0	0
ALPP	250	broad.mit.edu	37	2	233245442	233245442	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:233245442C>T	ENST00000392027.2	+	8	1244	c.975C>T	c.(973-975)ccC>ccT	p.P325P	AC068134.8_ENST00000441266.1_RNA|AC068134.8_ENST00000439072.1_RNA	NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	325						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		GCAGGAACCCCCGCGGCTTCT	0.647000													5	61					0	0	0.000157383	0	0
HMGB2	3148	broad.mit.edu	37	4	174253977	174253977	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:174253977C>T	ENST00000296503.5	-	4	1339	c.466G>A	c.(466-468)Gaa>Aaa	p.E156K	HMGB2_ENST00000446922.2_Missense_Mutation_p.E156K|HMGB2_ENST00000438704.2_Missense_Mutation_p.E156K			P26583	HMGB2_HUMAN	high mobility group box 2	156					base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|urinary_tract(3)	14		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TGTACCTTTTCATATTTCTCC	0.363000													11	173					0	0	0.000978159	0	0
TTN	7273	broad.mit.edu	37	2	179413377	179413377	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:179413377C>T	ENST00000589042.1	-	339	93200	c.92976G>A	c.(92974-92976)ggG>ggA	p.G30992G	TTN_ENST00000460472.2_Silent_p.G21927G|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Silent_p.G22119G|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000591111.1_Silent_p.G29351G|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Silent_p.G22052G|TTN_ENST00000342992.6_Silent_p.G28424G|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000438095.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29351	Fibronectin type-III 126.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGTATATTTCCCTGCATCAT	0.468000													15	114					0	0	0.000422831	0	0
NKAPL	222698	broad.mit.edu	37	6	28227579	28227579	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:28227579C>T	ENST00000343684.3	+	1	482	c.430C>T	c.(430-432)Cct>Tct	p.P144S		NM_001007531.1	NP_001007532.1	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	144										breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31						TCCAAAGTTCCCTCAGCTAGA	0.517000													19	145					0	0	0.00152264	0	0
EFCAB3	146779	broad.mit.edu	37	17	60472490	60472490	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:60472490C>T	ENST00000450662.2	+	8	656	c.585C>T	c.(583-585)atC>atT	p.I195I	EFCAB3_ENST00000305286.3_Silent_p.I143I	NM_001144933.1	NP_001138405.1	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3	143							calcium ion binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)	17			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			TGTTTGAAATCCTATCAAGGC	0.388000													21	119					0	0	0.000720815	0	0
OR8H1	219469	broad.mit.edu	37	11	56058290	56058290	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:56058290C>T	ENST00000313022.2	-	1	276	c.249G>A	c.(247-249)gcG>gcA	p.A83A		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	83					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					TCAGTAAGTTCGCTAAGGTTT	0.418000													18	231					0	0	0.00152264	0	0
OR2L3	391192	broad.mit.edu	37	1	248224258	248224258	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:248224258C>T	ENST00000359959.3	+	1	275	c.275C>T	c.(274-276)tCc>tTc	p.S92F	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	92					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			AAGTCTATCTCCTTCACTGGG	0.423000													17	186					0	0	0.00152264	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104961396	104961396	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chrX:104961396G>A	ENST00000372582.1	+	7	1565	c.809G>A	c.(808-810)gGa>gAa	p.G270E	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.G270E	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	270	Ig-like C2-type 3.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						GCATTCTTCGGATTCAGTGGA	0.433000													15	55					0	0	0.000308642	0	0
HEY1	23462	broad.mit.edu	37	8	80677781	80677781	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:80677781T>C	ENST00000337919.5	-	5	762	c.569A>G	c.(568-570)cAt>cGt	p.H190R	HEY1_ENST00000435063.2_5'UTR|HEY1_ENST00000354724.3_Missense_Mutation_p.H186R|HEY1_ENST00000523976.1_Missense_Mutation_p.H96R	NM_001040708.1	NP_001035798.1	Q9Y5J3	HEY1_HUMAN	hes-related family bHLH transcription factor with YRPW motif 1	186					angiogenesis|negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|transcription, DNA-dependent	nucleus	DNA binding|protein binding		HEY1/NCOA2(10)	cervix(1)|kidney(2)|large_intestine(5)|lung(14)	22	all_lung(9;5.1e-05)		Epithelial(68;0.076)|all cancers(69;0.179)			GTGCGGGTGATGTCCGAAGAC	0.692000			T	NCOA2	mesenchymal chondrosarcoma						OREG0018837	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	24					0	0	0.000602214	0	0
SLC8A3	6547	broad.mit.edu	37	14	70635016	70635016	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:70635016C>T	ENST00000381269.2	-	2	877	c.124G>A	c.(124-126)Ggg>Agg	p.G42R	SLC8A3_ENST00000528359.1_Missense_Mutation_p.G42R|SLC8A3_ENST00000534137.1_Missense_Mutation_p.G42R|SLC8A3_ENST00000357887.3_Missense_Mutation_p.G42R|SLC8A3_ENST00000356921.2_Missense_Mutation_p.G42R	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	42					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TTGTTCTGCCCTGTGCTTGGC	0.562000													5	20					0	0	0.000602214	0	0
HEPH	9843	broad.mit.edu	37	X	65409626	65409626	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chrX:65409626C>T	ENST00000519389.1	+	6	1250	c.1071C>T	c.(1069-1071)gtC>gtT	p.V357V	HEPH_ENST00000419594.1_Silent_p.V306V|HEPH_ENST00000441993.2_Silent_p.V306V|HEPH_ENST00000336279.5_Silent_p.V36V|HEPH_ENST00000374727.3_Silent_p.V306V|HEPH_ENST00000343002.2_Silent_p.V303V			Q9BQS7	HEPH_HUMAN	hephaestin	303	Plastocyanin-like 2.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						AAATTGATGTCCACACAGCAT	0.478000													7	16					0	0	8.12818e-05	0	0
TDRD5	163589	broad.mit.edu	37	1	179620142	179620142	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:179620142C>T	ENST00000444136.1	+	12	2191	c.1941C>T	c.(1939-1941)ttC>ttT	p.F647F	TDRD5_ENST00000367614.1_Silent_p.F647F|TDRD5_ENST00000294848.8_Silent_p.F647F	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	647					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						ATGTCTATTTCCATCATGTCT	0.383000													13	103					0	0	0.00185496	0	0
GRM3	2913	broad.mit.edu	37	7	86468472	86468472	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:86468472G>A	ENST00000361669.2	+	4	2741	c.1642G>A	c.(1642-1644)Gat>Aat	p.D548N	GRM3_ENST00000394720.2_Intron|GRM3_ENST00000546348.1_Missense_Mutation_p.D140N|GRM3_ENST00000439827.1_Intron|GRM3_ENST00000536043.1_Missense_Mutation_p.D420N	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	548					synaptic transmission	integral to plasma membrane		p.D548N(1)		NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TACCTGTATGGATTGTGGGTC	0.527000													7	88					0	0	0.000274275	0	0
IL1R2	7850	broad.mit.edu	37	2	102626224	102626224	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:102626224G>A	ENST00000332549.3	+	3	497	c.268G>A	c.(268-270)Gac>Aac	p.D90N	IL1R2_ENST00000393414.2_Missense_Mutation_p.D90N|IL1R2_ENST00000441002.1_Missense_Mutation_p.D90N	NM_004633.3	NP_004624.1	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II	90	Ig-like C2-type 1.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)	28					Anakinra(DB00026)	GTGGGCCCAGGACGGTGCTCT	0.597000													14	156					0	0	0.000566183	0	0
KCNJ3	3760	broad.mit.edu	37	2	155555733	155555733	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:155555733G>A	ENST00000295101.2	+	1	923	c.446G>A	c.(445-447)cGa>cAa	p.R149Q	KCNJ3_ENST00000544049.1_Missense_Mutation_p.R149Q	NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	149					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	TATGGCTACCGATACATCACA	0.557000													7	32					0	0	0.000157383	0	0
KLHDC1	122773	broad.mit.edu	37	14	50199475	50199475	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:50199475C>T	ENST00000359332.2	+	9	854	c.764C>T	c.(763-765)cCt>cTt	p.P255L	KLHDC1_ENST00000554512.1_3'UTR	NM_172193.2	NP_751943.1	Q8N7A1	KLDC1_HUMAN	kelch domain containing 1	255						cytoplasm				kidney(1)|large_intestine(1)|liver(2)|lung(5)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	12	all_epithelial(31;0.00244)|Breast(41;0.00964)					ACTTTAACACCTATAGCTGAT	0.333000													4	61					0	0	0.000602214	0	0
FBXO9	26268	broad.mit.edu	37	6	52957291	52957291	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:52957291C>T	ENST00000244426.6	+	7	920	c.748C>T	c.(748-750)Ccg>Tcg	p.P250S	FBXO9_ENST00000370939.3_Missense_Mutation_p.P206S|FBXO9_ENST00000323557.7_Missense_Mutation_p.P240S	NM_012347.4	NP_036479.1	Q9UK97	FBX9_HUMAN	F-box protein 9	250						ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)|large_intestine(4)|lung(1)|pancreas(2)|skin(1)	9	Lung NSC(77;0.103)					TAAACTTGTTCCGTACACGTC	0.418000													12	125					0	0	0.00185496	0	0
GPR65	8477	broad.mit.edu	37	14	88477602	88477602	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:88477602C>T	ENST00000267549.3	+	2	969	c.411C>T	c.(409-411)tcC>tcT	p.S137S	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	137					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						TCAGCCTGTCCATCTGGATAT	0.408000													15	127					0	0	0.000422831	0	0
ASXL1	171023	broad.mit.edu	37	20	31022685	31022685	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr20:31022685C>T	ENST00000375687.4	+	13	2594	c.2170C>T	c.(2170-2172)Ctg>Ttg	p.L724L	ASXL1_ENST00000306058.5_Silent_p.L719L	NM_015338.5	NP_056153.2	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	724					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						CCTGCCTTCTCTGAGAAAGGA	0.562000			"""F, N, Mis"""		"""MDS, CMML"""								4	26					0	0	0.000602214	0	0
WNT7A	7476	broad.mit.edu	37	3	13916511	13916511	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:13916511G>A	ENST00000285018.4	-	2	535	c.231C>T	c.(229-231)ttC>ttT	p.F77F	WNT7A_ENST00000497808.1_5'UTR	NM_004625.3	NP_004616.2	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family, member 7A	77					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	24						GGCCATTGCGGAACTGAAACT	0.607000													4	39					0	0	0.00116845	0	0
TRIT1	54802	broad.mit.edu	37	1	40312931	40312931	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:40312931G>A	ENST00000316891.5	-	8	981	c.967C>T	c.(967-969)Cgg>Tgg	p.R323W	TRIT1_ENST00000372818.1_Intron|TRIT1_ENST00000441669.2_Missense_Mutation_p.R241W|TRIT1_ENST00000545233.1_Missense_Mutation_p.R77W|TRIT1_ENST00000491865.1_5'UTR|TRIT1_ENST00000541099.1_Intron|TRIT1_ENST00000537223.1_Missense_Mutation_p.R19W|TRIT1_ENST00000537440.1_Missense_Mutation_p.R19W	NM_017646.4	NP_060116.2	Q9H3H1	MOD5_HUMAN	tRNA isopentenyltransferase 1	323	Interaction with substrate tRNA (By similarity).				tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			breast(1)|large_intestine(5)|liver(1)|lung(3)|ovary(2)|pancreas(1)|stomach(1)|urinary_tract(1)	15	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TTTTGTTTCCGGGCATATCTC	0.388000													6	49					0	0	0.000157383	0	0
TMEM99	147184	broad.mit.edu	37	17	38991348	38991348	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:38991348C>T	ENST00000301665.3	+	3	884	c.580C>T	c.(580-582)Cat>Tat	p.H194Y		NM_001195386.1|NM_001195387.1|NM_145274.3	NP_001182315.1|NP_001182316.1|NP_660317.2	Q8N816	TMM99_HUMAN	transmembrane protein 99	194						integral to membrane				cervix(1)|large_intestine(1)|lung(5)|skin(2)|urinary_tract(1)	10		Breast(137;0.000301)				TACTAGTTTTCATGACTTCTG	0.388000													8	63					0	0	0.000157383	0	0
DST	667	broad.mit.edu	37	6	56482993	56482993	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:56482993C>T	ENST00000370765.6	-	23	5946	c.5839G>A	c.(5839-5841)Gag>Aag	p.E1947K	DST_ENST00000370754.5_Intron|DST_ENST00000312431.6_Intron|DST_ENST00000244364.6_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000446842.2_Intron|DST_ENST00000361203.3_Intron|DST_ENST00000370769.4_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	1344					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTCTCTTTCTCGAGTGGAGCC	0.468000													5	48					0	0	0.000602214	0	0
ADCK2	90956	broad.mit.edu	37	7	140373514	140373514	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:140373514C>T	ENST00000072869.4	+	1	562	c.384C>T	c.(382-384)acC>acT	p.T128T	ADCK2_ENST00000476491.1_Silent_p.T128T	NM_052853.3	NP_443085.2	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	128						integral to membrane	ATP binding|protein serine/threonine kinase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|skin(4)	15	Melanoma(164;0.00956)					GCGTCTCCACCCTCTGGCTCC	0.627000													7	82					0	0	0.000157383	0	0
HLA-DOA	3111	broad.mit.edu	37	6	32974902	32974902	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:32974902C>T	ENST00000229829.5	-	4	779	c.704G>A	c.(703-705)gGc>gAc	p.G235D	HLA-DOA_ENST00000450833.2_Intron	NM_002119.3	NP_002110.1	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO alpha	235					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(1)	9						GAGGACGGTGCCCACGAGGAA	0.627000													8	68					0	0	0.000274275	0	0
STRA6	64220	broad.mit.edu	37	15	74473698	74473698	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr15:74473698G>A	ENST00000323940.5	-	17	1867	c.1622C>T	c.(1621-1623)gCc>gTc	p.A541V	STRA6_ENST00000449139.2_Missense_Mutation_p.A541V|STRA6_ENST00000574278.1_Missense_Mutation_p.A556V|STRA6_ENST00000574439.1_5'UTR|STRA6_ENST00000423167.2_Missense_Mutation_p.A532V|STRA6_ENST00000416286.3_Missense_Mutation_p.A533V|STRA6_ENST00000395105.4_Missense_Mutation_p.A541V|STRA6_ENST00000563965.1_Missense_Mutation_p.A580V|STRA6_ENST00000535552.1_Missense_Mutation_p.A578V	NM_001142617.1|NM_001142618.1|NM_001142619.1	NP_001136089.1|NP_001136090.1|NP_001136091.1	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid 6	541					adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(5)|skin(1)|stomach(2)	26						AAGGTGGATGGCGTTGTAGAG	0.632000													4	27					0	0	0.00024832	0	0
DLGAP3	58512	broad.mit.edu	37	1	35369961	35369961	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:35369961C>T	ENST00000373347.1	-	3	1292	c.1024G>A	c.(1024-1026)Gat>Aat	p.D342N	DLGAP3_ENST00000235180.4_Missense_Mutation_p.D342N			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	342					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				GGGTATCCATCCCGGCCCTGG	0.622000													8	48					0	0	0.000157383	0	0
ZNF280A	129025	broad.mit.edu	37	22	22868747	22868747	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr22:22868747G>A	ENST00000302097.3	-	2	1460	c.1208C>T	c.(1207-1209)tCg>tTg	p.S403L		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	403					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AAAGACCGACGATCTGTAATG	0.408000													7	88					0	0	0.000157383	0	0
OVGP1	5016	broad.mit.edu	37	1	111957374	111957374	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:111957374G>A	ENST00000369732.3	-	11	1804	c.1749C>T	c.(1747-1749)gtC>gtT	p.V583V		NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	583					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CTTCAGGGGTGACTGATATGT	0.517000													14	82					0	0	0.000219431	0	0
C4orf21	55345	broad.mit.edu	37	4	113524759	113524759	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:113524759G>A	ENST00000505019.1	-	10	3022	c.2897C>T	c.(2896-2898)cCa>cTa	p.P966L	C4orf21_ENST00000309071.5_Missense_Mutation_p.P966L	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	966										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		AGTGCTATCTGGAAACTGACT	0.413000													7	80					0	0	0.000157383	0	0
UNC13C	440279	broad.mit.edu	37	15	54305845	54305845	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr15:54305845G>A	ENST00000545554.1	+	1	745	c.745G>A	c.(745-747)Gaa>Aaa	p.E249K	UNC13C_ENST00000537900.1_Missense_Mutation_p.E249K|UNC13C_ENST00000260323.11_Missense_Mutation_p.E249K			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	249					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GATCTTTAAGGAACTTCAGGG	0.468000													14	51					0	0	0.000219431	0	0
GTF2H4	2968	broad.mit.edu	37	6	30880155	30880155	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:30880155C>T	ENST00000259895.4	+	11	1232	c.1009C>T	c.(1009-1011)Cgg>Tgg	p.R337W	GTF2H4_ENST00000376316.2_Missense_Mutation_p.R337W	NM_001517.4	NP_001508.1	Q92759	TF2H4_HUMAN	general transcription factor IIH, polypeptide 4, 52kDa	337			R -> Q (in dbSNP:rs3218820).		mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(3)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11						GATGCTCTATCGGTTCCCCAA	0.597000								Nucleotide excision repair (NER)					9	80					0	0	0.000978159	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44798971	44798971	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:44798971C>T	ENST00000309315.4	+	7	1028	c.905C>T	c.(904-906)tCc>tTc	p.S302F	ZMIZ2_ENST00000441627.1_Missense_Mutation_p.S302F|ZMIZ2_ENST00000265346.7_Missense_Mutation_p.S302F|ZMIZ2_ENST00000413916.1_Missense_Mutation_p.S270F|ZMIZ2_ENST00000433667.1_Missense_Mutation_p.S270F	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	302	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						CCTGCCCCCTCCCCTTCCTAC	0.652000													8	38					0	0	0.000274275	0	0
R3HDM1	23518	broad.mit.edu	37	2	136393490	136393490	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:136393490G>A	ENST00000264160.4	+	10	1099	c.729G>A	c.(727-729)aaG>aaA	p.K243K	R3HDM1_ENST00000409478.1_Silent_p.K199K|R3HDM1_ENST00000329971.3_Silent_p.K199K|R3HDM1_ENST00000410054.1_Silent_p.K187K|R3HDM1_ENST00000409606.1_Silent_p.K243K	NM_015361.2	NP_056176.2	Q15032	R3HD1_HUMAN	R3H domain containing 1	243							nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		AACATATTAAGGATGATAAAG	0.299000													20	160					0	0	0.000375601	0	0
CRYZL1	9946	broad.mit.edu	37	21	34975835	34975835	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr21:34975835G>A	ENST00000361534.2	-	8	551	c.412C>T	c.(412-414)Cca>Tca	p.P138S	CRYZL1_ENST00000381540.3_Missense_Mutation_p.P114S|CRYZL1_ENST00000381554.3_Missense_Mutation_p.P114S|AP000304.12_ENST00000429238.1_Intron|CRYZL1_ENST00000445393.1_Missense_Mutation_p.P76S|CRYZL1_ENST00000290244.5_Missense_Mutation_p.P99S			O95825	QORL1_HUMAN	crystallin, zeta (quinone reductase)-like 1	114					quinone cofactor metabolic process	cytosol	NADP binding|NADPH:quinone reductase activity|zinc ion binding			lung(1)|prostate(1)|urinary_tract(1)	3						ACCTTTTCTGGTTTATGAACT	0.433000													7	50					0	0	0.000157383	0	0
LYZL1	84569	broad.mit.edu	37	10	29599964	29599964	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr10:29599964G>A	ENST00000375500.3	+	5	618	c.561G>A	c.(559-561)tgG>tgA	p.W187*		NM_032517.4	NP_115906.3	Q6UWQ5	LYZL1_HUMAN	lysozyme-like 1	141					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			central_nervous_system(1)|cervix(2)|large_intestine(2)|lung(5)|skin(1)	11		Breast(68;0.203)				TGTCCGAGTGGAAAAAAGGCT	0.507000													13	142					0	0	0.000219431	0	0
BMS1P20	96610	broad.mit.edu	37	22	22657653	22657653	+	RNA	SNP	C	C	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr22:22657653C>A	ENST00000426066.1	+	0	65					NR_027293.1																						AATCGGGCCCCGATACTCAGG	0.498000													4	27					0.000602214	0.00305084	0.000602214	1	0
POLR2G	5436	broad.mit.edu	37	11	62532814	62532814	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:62532814C>T	ENST00000301788.7	+	5	441	c.336C>T	c.(334-336)tcC>tcT	p.S112S		NM_002696.2	NP_002687.1	P62487	RPB7_HUMAN	polymerase (RNA) II (DNA directed) polypeptide G	112					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA-directed RNA polymerase activity|protein binding|RNA binding			lung(3)	3						CCTTTCAGTCCATCCCTTCAG	0.463000													22	181					0	0	0.000878237	0	0
ANKRD50	57182	broad.mit.edu	37	4	125590863	125590863	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:125590863G>A	ENST00000504087.1	-	4	4606	c.3569C>T	c.(3568-3570)tCa>tTa	p.S1190L	ANKRD50_ENST00000515641.1_Missense_Mutation_p.S1011L	NM_020337.2	NP_065070.1	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	1190	Ser-rich.									NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(14)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	55						TCTCAAAGATGAATTTTTTGA	0.383000													21	83					0	0	0.00121646	0	0
HABP2	3026	broad.mit.edu	37	10	115337887	115337887	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr10:115337887G>A	ENST00000351270.3	+	6	647	c.551G>A	c.(550-552)gGg>gAg	p.G184E	HABP2_ENST00000537906.1_Missense_Mutation_p.G173R|HABP2_ENST00000541666.1_Missense_Mutation_p.G184E|HABP2_ENST00000542051.1_Missense_Mutation_p.G158E	NM_004132.3	NP_004123.1	Q14520	HABP2_HUMAN	hyaluronan binding protein 2	184	EGF-like 3.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		CAGTTCAAGGGGAAATTCTGT	0.547000													14	51					0	0	0.00074312	0	0
GRIK5	2901	broad.mit.edu	37	19	42546759	42546759	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:42546759C>T	ENST00000262895.3	-	11	1417	c.1418G>A	c.(1417-1419)gGg>gAg	p.G473E	GRIK5_ENST00000593562.1_Missense_Mutation_p.G473E|GRIK5_ENST00000301218.4_Missense_Mutation_p.G473E	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	473						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	CTCGGGCGCCCCGTACAGCCC	0.672000													4	49					0	0	0.00116845	0	0
NACA2	342538	broad.mit.edu	37	17	59668330	59668330	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:59668330C>T	ENST00000521764.1	-	1	233	c.212G>A	c.(211-213)cGg>cAg	p.R71Q		NM_199290.3	NP_954984.1	Q9H009	NACA2_HUMAN	nascent polypeptide-associated complex alpha subunit 2	71	NAC-A/B.				protein transport	cytoplasm|nucleus				large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	12	all_epithelial(1;3.12e-14)					CTTTTCACTCCGACTCTGTTT	0.458000													22	169					0	0	0.000295444	0	0
VHLL	391104	broad.mit.edu	37	1	156268578	156268578	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:156268578G>A	ENST00000339922.3	-	1	850	c.403C>T	c.(403-405)Ctg>Ttg	p.L135L		NM_001004319.2	NP_001004319.1	Q6RSH7	VHLL_HUMAN	von Hippel-Lindau tumor suppressor-like	135	Beta-domain.				protein ubiquitination	nucleus				endometrium(1)|lung(2)|ovary(1)	4	Hepatocellular(266;0.158)					ATACACTGCAGTGTGATGTTG	0.453000													16	123					0	0	0.00074312	0	0
OR4N2	390429	broad.mit.edu	37	14	20295781	20295781	+	Silent	SNP	C	C	T	rs141509885	byFrequency	TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:20295781C>T	ENST00000568211.1	+	1	174	c.174C>T	c.(172-174)ccC>ccT	p.P58P	OR4N2_ENST00000315947.1_Silent_p.P58P			Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P58P(1)		breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCACAGCCCCCCTCTATTTCT	0.463000													26	217					0	0	0.000878237	0	0
DNAH9	1770	broad.mit.edu	37	17	11660968	11660968	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:11660968C>T	ENST00000262442.3	+	35	7022	c.6954C>T	c.(6952-6954)ttC>ttT	p.F2318F	DNAH9_ENST00000454412.2_Silent_p.F2318F	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2318	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCATTTTGTTCGACAAGTATC	0.473000													11	42					0	0	0.000219431	0	0
OR1Q1	158131	broad.mit.edu	37	9	125377721	125377721	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr9:125377721G>A	ENST00000297913.2	+	1	774	c.705G>A	c.(703-705)tgG>tgA	p.W235*	RP11-64P14.7_ENST00000431442.1_RNA	NM_012364.1	NP_036496.1	Q15612	OR1Q1_HUMAN	olfactory receptor, family 1, subfamily Q, member 1	235					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.W235*(1)		NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)	17						AGGGCAGGTGGAAAACCTTTT	0.552000													14	70					0	0	0.00185496	0	0
EYA1	2138	broad.mit.edu	37	8	72123391	72123391	+	Splice_Site	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:72123391C>T	ENST00000340726.3	-	17	2337	c.1698_splice	c.e17+1	p.K566_splice	EYA1_ENST00000388740.3_Splice_Site_p.K533_splice|EYA1_ENST00000388743.2_Splice_Site_p.K565_splice|EYA1_ENST00000303824.7_Splice_Site_p.K560_splice|EYA1_ENST00000388742.4_Splice_Site_p.K566_splice|EYA1_ENST00000388741.2_Splice_Site_p.K532_splice|EYA1_ENST00000419131.1_Splice_Site_p.K531_splice	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	566					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			GAATGCTCACCTTTTTTGCTC	0.358000													5	85					0	0	8.12818e-05	0	0
EEF2K	29904	broad.mit.edu	37	16	22285017	22285017	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr16:22285017C>T	ENST00000263026.5	+	16	2309	c.1835C>T	c.(1834-1836)tCc>tTc	p.S612F		NM_013302.3	NP_037434.1	O00418	EF2K_HUMAN	eukaryotic elongation factor-2 kinase	612	Pseudosubstrate/autoinhibitory domain (Potential).				insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(8)|large_intestine(2)|lung(13)|ovary(1)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(48;0.0223)		GACAGGCAGTCCATGATCCTA	0.527000													10	42					0	0	0.000442599	0	0
STAC	6769	broad.mit.edu	37	3	36534657	36534657	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:36534657G>A	ENST00000273183.3	+	6	1002	c.702G>A	c.(700-702)gtG>gtA	p.V234V	STAC_ENST00000457375.2_Silent_p.V173V|STAC_ENST00000476388.1_3'UTR	NM_003149.1	NP_003140.1	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	234					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			endometrium(5)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(5)	32						CAGATCTTGTGGAGGTTCCTG	0.483000													7	88					0	0	0.000157383	0	0
UGP2	7360	broad.mit.edu	37	2	64085049	64085049	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:64085049C>T	ENST00000337130.5	+	3	710	c.234C>T	c.(232-234)atC>atT	p.I78I	UGP2_ENST00000487469.1_Intron|UGP2_ENST00000467648.2_Silent_p.I67I|UGP2_ENST00000445915.2_Silent_p.I87I|UGP2_ENST00000394417.2_Silent_p.I67I	NM_006759.3	NP_006750.3	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2	78					glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)	18						GGGGAAAAATCCAGAGACCCC	0.408000													9	193					0	0	0.000274275	0	0
OSM	5008	broad.mit.edu	37	22	30659972	30659972	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr22:30659972C>T	ENST00000215781.2	-	3	699	c.659G>A	c.(658-660)cGg>cAg	p.R220Q	OSM_ENST00000403389.1_Missense_Mutation_p.R199Q	NM_020530.4	NP_065391.1	P13725	ONCM_HUMAN	oncostatin M	220					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|skin(3)	11			Epithelial(10;0.206)			GCTGTGTCTCCGGCTCCGGTT	0.657000													7	53					0	0	0.000274275	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69046428	69046428	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:69046428A>G	ENST00000295381.3	+	9	1593	c.1174A>G	c.(1174-1176)Agg>Ggg	p.R392G	ARHGAP25_ENST00000467265.1_Missense_Mutation_p.R353G|ARHGAP25_ENST00000409202.3_Missense_Mutation_p.R393G|ARHGAP25_ENST00000479844.1_Missense_Mutation_p.R86G|ARHGAP25_ENST00000497079.1_Missense_Mutation_p.R386G|ARHGAP25_ENST00000409220.1_Missense_Mutation_p.R386G|ARHGAP25_ENST00000409030.3_Missense_Mutation_p.R385G	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	392					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						CCGAATTTCTAGGACAGACAG	0.537000													5	65					0	0	0.000602214	0	0
ADAM30	11085	broad.mit.edu	37	1	120437452	120437452	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:120437452C>T	ENST00000369400.1	-	1	1666	c.1508G>A	c.(1507-1509)aGa>aAa	p.R503K		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	503	Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CTGCATATATCTGGATCTGCA	0.458000													52	450					0	0	0.000781405	0	0
DNAH2	146754	broad.mit.edu	37	17	7722089	7722089	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:7722089C>T	ENST00000572933.1	+	70	12125	c.10665C>T	c.(10663-10665)atC>atT	p.I3555I	DNAH2_ENST00000389173.2_Silent_p.I3555I			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3555	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AGGATGAGATCCTGCGGTGAG	0.632000													6	38					0	0	0.00116845	0	0
STAT3	6774	broad.mit.edu	37	17	40467771	40467771	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:40467771G>A	ENST00000264657.5	-	24	2617	c.2305C>T	c.(2305-2307)Ccc>Tcc	p.P769S	STAT3_ENST00000588969.1_Missense_Mutation_p.P769S|STAT3_ENST00000585517.1_3'UTR|STAT3_ENST00000404395.3_Missense_Mutation_p.P768S|STAT3_ENST00000389272.3_Missense_Mutation_p.P671S	NM_003150.3|NM_139276.2	NP_003141.2|NP_644805.1	P40763	STAT3_HUMAN	signal transducer and activator of transcription 3 (acute-phase response factor)	769					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		CCTCACATGGGGGAGGTAGCG	0.557000									Hyperimmunoglobulin E Recurrent Infection Syndrome				8	56					0	0	0.000274275	0	0
MICAL1	64780	broad.mit.edu	37	6	109773593	109773593	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:109773593G>A	ENST00000368952.4	-	6	1035	c.745C>T	c.(745-747)Cga>Tga	p.R249*	MICAL1_ENST00000358807.3_Nonsense_Mutation_p.R230*|MICAL1_ENST00000358577.3_Nonsense_Mutation_p.R230*|MICAL1_ENST00000483856.1_5'UTR			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	230					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		CGCATTTCTCGAACTTTGAAG	0.537000													10	96					0	0	0.000442599	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651976	84651976	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr15:84651976G>A	ENST00000286744.5	+	21	3820	c.3596G>A	c.(3595-3597)gGa>gAa	p.G1199E	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.G1199E	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1199	Ig-like C2-type 2.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCCAGGATTGGAAATACAGTA	0.413000													20	135					0	0	0.00121646	0	0
OR10W1	81341	broad.mit.edu	37	11	58035019	58035019	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:58035019G>A	ENST00000395079.2	-	1	713	c.312C>T	c.(310-312)ttC>ttT	p.F104F		NM_207374.3	NP_997257.2	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W, member 1	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(1)	26		Breast(21;0.0589)				CAGCCAAGAGGAAGCAATCAG	0.537000													9	46					0	0	0.000673444	0	0
IL36B	27177	broad.mit.edu	37	2	113783768	113783768	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:113783768C>T	ENST00000259213.4	-	5	410	c.303G>A	c.(301-303)tgG>tgA	p.W101*		NM_014438.3	NP_055253.2	Q9NZH7	IL36B_HUMAN	interleukin 36, beta	101					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			kidney(1)|ovary(1)|pancreas(1)	3						caactagtttccagcaagtgt	0.468000													6	64					0	0	0.00116845	0	0
UGT3A2	167127	broad.mit.edu	37	5	36049295	36049295	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:36049295G>A	ENST00000282507.3	-	4	640	c.539C>T	c.(538-540)cCc>cTc	p.P180L	UGT3A2_ENST00000504954.1_Intron|UGT3A2_ENST00000545528.1_Intron|UGT3A2_ENST00000513300.1_Missense_Mutation_p.P146L	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	180						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATAAGACAAGGGGATTGGTAG	0.458000													9	34					0	0	0.000274275	0	0
UBAC2	337867	broad.mit.edu	37	13	100020041	100020041	+	Splice_Site	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr13:100020041G>A	ENST00000376440.2	+	6	1206	c.702_splice	c.e6-1	p.G235_splice	UBAC2_ENST00000460562.1_3'UTR|UBAC2_ENST00000403766.3_Splice_Site_p.G270_splice	NM_177967.3	NP_808882.1	Q8NBM4	UBAC2_HUMAN	UBA domain containing 2	270						integral to membrane				breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)	10	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CTCTTTTTAGGGAGGAATGAT	0.458000													9	72					0	0	0.000274275	0	0
C14orf39	317761	broad.mit.edu	37	14	60921826	60921826	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:60921826C>T	ENST00000321731.3	-	16	1555	c.1396G>A	c.(1396-1398)Gaa>Aaa	p.E466K		NM_174978.2	NP_777638.2	Q08AQ4	Q08AQ4_HUMAN	chromosome 14 open reading frame 39	466										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		GATTCCTTTTCTGTTTGAACT	0.299000													5	67					0	0	8.12818e-05	0	0
NPAS4	266743	broad.mit.edu	37	11	66191942	66191942	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:66191942C>T	ENST00000311034.2	+	7	1757	c.1581C>T	c.(1579-1581)gcC>gcT	p.A527A		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	527					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						GCAGCCCTGCCCATGAACAGC	0.592000													12	137					0	0	0.000219431	0	0
WIF1	11197	broad.mit.edu	37	12	65514233	65514233	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:65514233G>A	ENST00000286574.4	-	2	626	c.252C>T	c.(250-252)atC>atT	p.I84I		NM_007191.4	NP_009122.2	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1	84	WIF.				multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			cervix(1)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	21			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		TCATGGAATGGATATTGACAG	0.403000			T	HMGA2	pleomorphic salivary gland adenoma								15	109					0	0	0.000219431	0	0
DSCAML1	57453	broad.mit.edu	37	11	117651359	117651359	+	Silent	SNP	C	C	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:117651359C>A	ENST00000321322.6	-	2	394	c.393G>T	c.(391-393)ccG>ccT	p.P131P	DSCAML1_ENST00000527706.1_Intron	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	71	Ig-like C2-type 2.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GCCGGATGTGCGGCACGTCGT	0.667000													7	104					0.000157383	0.000798817	0.000157383	1	0
ME1	4199	broad.mit.edu	37	6	84117513	84117513	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:84117513G>A	ENST00000369705.3	-	2	302	c.186C>T	c.(184-186)ttC>ttT	p.F62F	ME1_ENST00000541327.1_Intron|ME1_ENST00000543031.1_Intron	NM_002395.4	NP_002386.1	P48163	MAOX_HUMAN	malic enzyme 1, NADP(+)-dependent, cytosolic	62					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			NS(2)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	TCAGATGCTCGAAATTTTTTA	0.383000													11	99					0	0	0.00136819	0	0
LUZP4	51213	broad.mit.edu	37	X	114540930	114540930	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chrX:114540930G>A	ENST00000371920.3	+	4	510	c.503G>A	c.(502-504)aGa>aAa	p.R168K	LUZP4_ENST00000451986.2_Missense_Mutation_p.R86K	NM_016383.3	NP_057467.1	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	168						nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						CACTTAGAGAGATCTCTTTCT	0.443000													16	43					0	0	0.000308642	0	0
STEAP1B	256227	broad.mit.edu	37	7	22533211	22533211	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:22533211G>A	ENST00000404369.4	-	3	744	c.329C>T	c.(328-330)cCa>cTa	p.P110L	STEAP1B_ENST00000406890.2_Missense_Mutation_p.P91L	NM_001164460.1	NP_001157932.1	Q6NZ63	STEAL_HUMAN	STEAP family member 1B	91						integral to membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			endometrium(1)|kidney(1)|lung(2)	4						GACCAGGATTGGAATTTTATA	0.388000													7	41					0	0	0.000274275	0	0
GLYATL1	92292	broad.mit.edu	37	11	58714518	58714518	+	Splice_Site	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:58714518G>A	ENST00000300079.5	+	3	198		c.e3-1		GLYATL1_ENST00000317391.4_Splice_Site|RP11-142C4.6_ENST00000533954.1_RNA	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1							mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	TATCTTTTCAGAGTTTCTTCT	0.388000													6	60					0	0	8.12818e-05	0	0
TTN	7273	broad.mit.edu	37	2	179596793	179596793	+	Splice_Site	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:179596793C>T	ENST00000589042.1	-	57	17127	c.16903_splice	c.e57+1	p.E5635_splice	TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Splice_Site_p.E5318_splice|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Splice_Site_p.E4391_splice|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5318	Ig-like 37.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAACACAAACCTTTGACTATT	0.453000													15	152					0	0	0.000422831	0	0
TAS2R38	5726	broad.mit.edu	37	7	141673246	141673246	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:141673246G>A	ENST00000547270.1	-	1	327	c.244C>T	c.(244-246)Cag>Tag	p.Q82*		NM_176817.4	NP_789787.4	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	82					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			NS(2)|breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)|stomach(1)	21	Melanoma(164;0.0171)					CTCAACTTCTGGAAGTGGGTA	0.527000													18	136					0	0	0.00188189	0	0
NPY1R	4886	broad.mit.edu	37	4	164246583	164246583	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:164246583G>A	ENST00000296533.2	-	3	1558	c.1027C>T	c.(1027-1029)Cgg>Tgg	p.R343W	NPY1R_ENST00000509586.1_Missense_Mutation_p.R100W	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	343					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding	p.R343W(1)		breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TCATCATCCCGAGACCGGAAA	0.393000													6	90					0	0	0.00116845	0	0
ADAM20	8748	broad.mit.edu	37	14	70990201	70990201	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:70990201G>A	ENST00000256389.3	-	2	1668	c.1424C>T	c.(1423-1425)aCc>aTc	p.T475I	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	425	Disintegrin.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		CTGCCGTATGGTTCCACAGTC	0.433000													22	120					0	0	0.000586117	0	0
SULF1	23213	broad.mit.edu	37	8	70536203	70536203	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:70536203C>T	ENST00000260128.4	+	15	2338	c.1621C>T	c.(1621-1623)Cgg>Tgg	p.R541W	SULF1_ENST00000419716.3_Missense_Mutation_p.R541W|SULF1_ENST00000402687.4_Missense_Mutation_p.R541W|SULF1_ENST00000458141.2_Missense_Mutation_p.R541W|SULF1_ENST00000521946.1_3'UTR	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	541					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TGTCCATACTCGGCAGACACG	0.413000													9	72					0	0	0.000673444	0	0
HAX1	10456	broad.mit.edu	37	1	154245824	154245824	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:154245824C>T	ENST00000328703.7	+	2	279	c.66C>T	c.(64-66)ccC>ccT	p.P22P	HAX1_ENST00000457918.2_Intron|HAX1_ENST00000483970.2_Silent_p.P22P|HAX1_ENST00000532105.1_Intron	NM_006118.3	NP_006109.2	O00165	HAX1_HUMAN	HCLS1 associated protein X-1	22	Required for localization in mitochondria (By similarity).					actin cytoskeleton|cytoplasmic membrane-bounded vesicle|lamellipodium|mitochondrion|nuclear membrane|sarcoplasmic reticulum|soluble fraction	interleukin-1 binding|protein N-terminus binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	15	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ACAGAGATCCCTTTTTTGGAG	0.493000									Kostmann syndrome				13	74					0	0	0.000219431	0	0
SPHKAP	80309	broad.mit.edu	37	2	228886589	228886589	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:228886589G>A	ENST00000392056.3	-	6	581	c.535C>T	c.(535-537)Ctg>Ttg	p.L179L	SPHKAP_ENST00000344657.5_Silent_p.L179L	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	179						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		AGACCAATCAGAAATTTGTTG	0.458000													9	57					0	0	0.000673444	0	0
PCOLCE	5118	broad.mit.edu	37	7	100200087	100200087	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:100200087C>T	ENST00000223061.5	+	1	288	c.8C>T	c.(7-9)cCt>cTt	p.P3L	PCOLCE_ENST00000496269.1_3'UTR|PCOLCE-AS1_ENST00000544873.1_RNA|PCOLCE-AS1_ENST00000442166.2_RNA	NM_002593.3	NP_002584.2	Q15113	PCOC1_HUMAN	procollagen C-endopeptidase enhancer	3					multicellular organismal development	extracellular space	collagen binding|heparin binding|peptidase activator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GCCATGCTGCCTGCAGCCACA	0.652000													5	39					0	0	0.000602214	0	0
AHNAK2	113146	broad.mit.edu	37	14	105415514	105415514	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:105415514C>T	ENST00000333244.5	-	7	6393	c.6274G>A	c.(6274-6276)Gac>Aac	p.D2092N	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2092						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCTTGATGTCCACCTGGGGG	0.617000													16	55					0	0	0.000422831	0	0
PRDM9	56979	broad.mit.edu	37	5	23524491	23524491	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:23524491C>T	ENST00000296682.3	+	10	1181	c.999C>T	c.(997-999)ttC>ttT	p.F333F		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	333	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						TGGTGGCCTTCCAGTACCACA	0.537000										HNSCC(3;0.000094)			6	40					0	0	0.000274275	0	0
CMAS	55907	broad.mit.edu	37	12	22199428	22199428	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:22199428A>G	ENST00000229329.2	+	1	321	c.191A>G	c.(190-192)aAg>aGg	p.K64R		NM_018686.4	NP_061156.1	Q8NFW8	NEUA_HUMAN	cytidine monophosphate N-acetylneuraminic acid synthetase	64					lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24						AAGAACATTAAGCACCTGGCG	0.692000													3	14					0	0	6.4e-05	0	0
CDCP1	64866	broad.mit.edu	37	3	45135052	45135052	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:45135052C>T	ENST00000296129.1	-	6	1478	c.1344G>A	c.(1342-1344)tgG>tgA	p.W448*		NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	448	CUB.					extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		CCAGCAGCTTCCAGGAGAAGT	0.597000													9	68					0	0	0.000442599	0	0
NDUFV3	4731	broad.mit.edu	37	21	44323701	44323701	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr21:44323701C>T	ENST00000354250.2	+	3	648	c.579C>T	c.(577-579)tcC>tcT	p.S193S	NDUFV3_ENST00000340344.3_Intron|NDUFV3_ENST00000460259.1_3'UTR	NM_021075.3	NP_066553.3	P56181	NDUV3_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	24					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	10				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	CCTCTCATTCCTTTGAAAACA	0.517000													9	82					0	0	0.000442599	0	0
CFAP54	144535	broad.mit.edu	37	12	97147664	97147664	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:97147664C>T	ENST00000524981.3	+	23	3181	c.3181C>T	c.(3181-3183)Ctt>Ttt	p.L1061F				Q6ZTY8	CL063_HUMAN		1035										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						AGCTGAAATCCTTTTTCAGAA	0.423000													6	47					0	0	0.00116845	0	0
LPPR2	64748	broad.mit.edu	37	19	11468409	11468409	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:11468409C>T	ENST00000251473.5	+	3	436	c.60C>T	c.(58-60)ttC>ttT	p.F20F	DKFZP761J1410_ENST00000591608.1_Silent_p.F20F|DKFZP761J1410_ENST00000586431.1_3'UTR	NM_001170635.1|NM_022737.2	NP_001164106.1|NP_073574.2																					GCTTTGTCTTCGTGGAGGTGA	0.582000													4	16					0	0	8.12818e-05	0	0
COL4A4	1286	broad.mit.edu	37	2	227967551	227967551	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:227967551A>G	ENST00000396625.3	-	15	1091	c.884T>C	c.(883-885)aTt>aCt	p.I295T	COL4A4_ENST00000329662.7_Missense_Mutation_p.I295T	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	295	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TTTTGCCCCAATACCAGATTC	0.383000													19	143					0	0	0.000375601	0	0
RNF133	168433	broad.mit.edu	37	7	122338646	122338646	+	Silent	SNP	A	A	G			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:122338646A>G	ENST00000340112.2	-	1	564	c.327T>C	c.(325-327)ggT>ggC	p.G109G	CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000313070.7_Intron|CADPS2_ENST00000449022.2_Intron|CADPS2_ENST00000412584.2_Intron	NM_139175.1	NP_631914.1	Q8WVZ7	RN133_HUMAN	ring finger protein 133	109	PA.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21						TGAAGGTACAACCTCCCCGTT	0.463000													11	117					0	0	0.00136819	0	0
KCNH5	27133	broad.mit.edu	37	14	63174561	63174561	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:63174561C>T	ENST00000322893.7	-	11	2900	c.2632G>A	c.(2632-2634)Gct>Act	p.A878T	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	878					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GCCTCCCCAGCCTTATCCAAA	0.502000													9	72					0	0	0.000442599	0	0
SLC38A11	151258	broad.mit.edu	37	2	165793875	165793875	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:165793875G>A	ENST00000303735.4	-	5	698	c.368C>T	c.(367-369)tCa>tTa	p.S123L	SLC38A11_ENST00000409662.1_Missense_Mutation_p.S145L|SLC38A11_ENST00000409149.3_Missense_Mutation_p.S145L|SLC38A11_ENST00000493887.1_5'UTR|SLC38A11_ENST00000409058.1_Missense_Mutation_p.S176L	NM_173512.2	NP_775783.1	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	145					amino acid transport|sodium ion transport	integral to membrane				endometrium(2)|large_intestine(4)|lung(8)|ovary(1)	15						TGGACCCAGTGAAATTGCCCT	0.358000													14	117					0	0	0.00074312	0	0
CCDC3	83643	broad.mit.edu	37	10	12940532	12940532	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr10:12940532T>G	ENST00000378839.1	-	7	1274	c.322A>C	c.(322-324)Aag>Cag	p.K108Q	CCDC3_ENST00000378825.3_Missense_Mutation_p.K233Q			Q9BQI4	CCDC3_HUMAN	coiled-coil domain containing 3	233						endoplasmic reticulum|extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|prostate(2)	11		Ovarian(717;0.0822)	BRCA - Breast invasive adenocarcinoma(52;0.163)			CGGCCCTTCTTACGCGCCTGC	0.667000													5	49					0	0	0.000602214	0	0
RAPGEF5	9771	broad.mit.edu	37	7	22306590	22306590	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:22306590C>T	ENST00000344041.6	-	7	642	c.330G>A	c.(328-330)agG>agA	p.R110R	RAPGEF5_ENST00000475788.1_5'UTR|RAPGEF5_ENST00000405243.1_Silent_p.R263R	NM_012294.3	NP_036426.3	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	0	N-terminal Ras-GEF.				nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|ovary(1)	6						TACCAGACTTCCTTGCTTTCA	0.393000													13	62					0	0	0.00185496	0	0
AC015849.16	0	broad.mit.edu	37	17	34236586	34236586	+	RNA	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:34236586G>A	ENST00000587132.1	-	0	1441																											CAGGTCCAAAGGTTGAAGTGT	0.468000													3	9					0	0	6.4e-05	0	0
C2CD3	26005	broad.mit.edu	37	11	73748620	73748620	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:73748620G>A	ENST00000334126.7	-	30	6010	c.5784C>T	c.(5782-5784)gaC>gaT	p.D1928D	C2CD3_ENST00000313663.7_Silent_p.D1928D			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1928						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					GCCCAAGATGGTCCCTACAGC	0.552000													17	83					0	0	0.000566183	0	0
FCRL4	83417	broad.mit.edu	37	1	157556203	157556203	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:157556203C>T	ENST00000271532.1	-	6	1025	c.890G>A	c.(889-891)gGg>gAg	p.G297E	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	297	Ig-like C2-type 4.					integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				AGCCTGGCCCCCTGAGGGCTG	0.612000													5	45					0	0	0.000157383	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41430298	41430298	+	RNA	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:41430298G>A	ENST00000599198.1	+	0	175					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						GCCCCTTTTGGGGAACCTTCT	0.577000													8	60					0	0	0.000274275	0	0
C1orf173	127254	broad.mit.edu	37	1	75036989	75036989	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:75036989C>T	ENST00000326665.5	-	14	4623	c.4405G>A	c.(4405-4407)Gga>Aga	p.G1469R	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1469	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCAGCTGCTCCTGTCTCCTGC	0.582000													10	96					0	0	0.00136819	0	0
KCNH5	27133	broad.mit.edu	37	14	63174974	63174974	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:63174974G>A	ENST00000322893.7	-	11	2487	c.2219C>T	c.(2218-2220)tCc>tTc	p.S740F	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	740					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ATTCTGTAAGGAGCGGCTCTC	0.532000													9	71					0	0	0.000274275	0	0
CDH23	64072	broad.mit.edu	37	10	73406336	73406336	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr10:73406336G>A	ENST00000224721.6	+	13	1431	c.1426G>A	c.(1426-1428)Gag>Aag	p.E476K	CDH23_ENST00000299366.7_Missense_Mutation_p.E516K|CDH23_ENST00000461841.3_Missense_Mutation_p.E516K|CDH23_ENST00000398842.3_Missense_Mutation_p.E471K|CDH23_ENST00000398809.4_Missense_Mutation_p.E471K	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	471	Cadherin 5.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CAGCCTGTACGAGAACGTCAC	0.582000													11	98					0	0	0.00136819	0	0
FPR1	2357	broad.mit.edu	37	19	52249706	52249706	+	Missense_Mutation	SNP	G	G	A	rs146075164		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:52249706G>A	ENST00000595042.1	-	3	683	c.542C>T	c.(541-543)tCg>tTg	p.S181L	FPR1_ENST00000304748.4_Missense_Mutation_p.S181L	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	181					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity	p.S181L(1)		endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	GGTCCAGGGCGAAAAGTTAAA	0.527000													12	67					0	0	0.00136819	0	0
LIMCH1	22998	broad.mit.edu	37	4	41683077	41683077	+	Splice_Site	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:41683077G>A	ENST00000313860.7	+	20	2619		c.e20+1		LIMCH1_ENST00000509277.1_Splice_Site|LIMCH1_ENST00000503057.1_Splice_Site|LIMCH1_ENST00000508501.1_Splice_Site|LIMCH1_ENST00000513024.1_Splice_Site|LIMCH1_ENST00000511496.1_Splice_Site|LIMCH1_ENST00000381753.4_Splice_Site|LIMCH1_ENST00000512632.1_Splice_Site|LIMCH1_ENST00000512820.1_Splice_Site|LIMCH1_ENST00000514096.1_Splice_Site|LIMCH1_ENST00000396595.3_Splice_Site|LIMCH1_ENST00000512946.1_Splice_Site	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1						actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						TGGGACAATGGTGAGACCACA	0.408000													8	103					0	0	0.000274275	0	0
DENND3	22898	broad.mit.edu	37	8	142185557	142185557	+	Splice_Site	SNP	A	A	G			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:142185557A>G	ENST00000519811.1	+	14	2604	c.2535_splice	c.e14+1	p.E845_splice	DENND3_ENST00000424248.1_Splice_Site_p.E713_splice|DENND3_ENST00000262585.2_Splice_Site_p.E765_splice			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	765										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			AGAAATATAGAGGTAAGGACA	0.567000											OREG0019025	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	55					0	0	0.000157383	0	0
PPP6C	5537	broad.mit.edu	37	9	127912080	127912080	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr9:127912080G>A	ENST00000451402.1	-	8	1121	c.901C>T	c.(901-903)Cgt>Tgt	p.R301C	PPP6C_ENST00000415905.1_Missense_Mutation_p.R242C|PPP6C_ENST00000373547.4_Missense_Mutation_p.R264C|PPP6C_ENST00000373546.3_Missense_Mutation_p.R117C	NM_001123355.1	NP_001116827.1	O00743	PPP6_HUMAN	protein phosphatase 6, catalytic subunit	264					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity	p.R264C(3)|p.R301C(1)		NS(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(2)|ovary(1)|skin(3)	14						TTTCCACAACGATAGCAGTAA	0.403000													5	48					0	0	0.000602214	0	0
HYOU1	10525	broad.mit.edu	37	11	118922275	118922275	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:118922275C>T	ENST00000404233.3	-	13	1525	c.1401G>A	c.(1399-1401)cgG>cgA	p.R467R	HYOU1_ENST00000525859.1_Silent_p.R467R|HYOU1_ENST00000529972.1_Silent_p.R467R|HYOU1_ENST00000543287.1_Silent_p.R380R	NM_001130991.1|NM_006389.3	NP_001124463.1|NP_006380.1	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1	467						endoplasmic reticulum lumen	ATP binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(10)|prostate(1)|skin(2)	33	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		AGAAGAGTACCCGTTTATTGT	0.542000													7	44					0	0	8.12818e-05	0	0
SERPINB7	8710	broad.mit.edu	37	18	61471612	61471612	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr18:61471612C>T	ENST00000398019.2	+	8	1211	c.886C>T	c.(886-888)Ctg>Ttg	p.L296L	SERPINB7_ENST00000336429.2_Silent_p.L296L|SERPINB7_ENST00000540675.1_Silent_p.L279L|SERPINB7_ENST00000546027.1_Silent_p.L296L	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	296					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity	p.L296L(1)		central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				AGCCCTAGGGCTGAAAGATAT	0.393000													6	51					0	0	8.12818e-05	0	0
BMP4	652	broad.mit.edu	37	14	54416795	54416795	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:54416795C>T	ENST00000245451.4	-	4	1575	c.1182G>A	c.(1180-1182)ctG>ctA	p.L394L	BMP4_ENST00000558984.1_Silent_p.L394L|BMP4_ENST00000417573.1_Silent_p.L394L|BMP4_ENST00000559087.1_Silent_p.L394L	NM_001202.3	NP_001193.2	P12644	BMP4_HUMAN	bone morphogenetic protein 4	394					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|prostate(3)|urinary_tract(1)	19						GATAATTTTTCAGTACCACCT	0.473000													7	75					0	0	0.000157383	0	0
SCN11A	11280	broad.mit.edu	37	3	38949515	38949515	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:38949515C>T	ENST00000450244.1	-	10	1596	c.1398G>A	c.(1396-1398)agG>agA	p.R466R	SCN11A_ENST00000456224.3_Silent_p.R466R|SCN11A_ENST00000302328.3_Silent_p.R466R|SCN11A_ENST00000444237.2_Silent_p.R466R			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	466					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AGAAGGACTTCCTTTTCTTAT	0.403000													12	80					0	0	0.000978159	0	0
UNC13B	10497	broad.mit.edu	37	9	35403774	35403774	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr9:35403774C>T	ENST00000378495.3	+	39	4742	c.4520C>T	c.(4519-4521)tCc>tTc	p.S1507F	UNC13B_ENST00000378496.4_Missense_Mutation_p.S1526F|UNC13B_ENST00000396787.1_Missense_Mutation_p.S1538F	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	1507	C2 3.				excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GGGCCCGAGTCCTATGAGTTG	0.552000													6	31					0	0	8.12818e-05	0	0
SCN11A	11280	broad.mit.edu	37	3	38924850	38924850	+	Missense_Mutation	SNP	G	G	C			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:38924850G>C	ENST00000450244.1	-	18	3291	c.3093C>G	c.(3091-3093)agC>agG	p.S1031R	SCN11A_ENST00000456224.3_Missense_Mutation_p.S993R|SCN11A_ENST00000302328.3_Missense_Mutation_p.S1031R|SCN11A_ENST00000444237.2_Missense_Mutation_p.S1031R			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1031					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TCTTGTCCACGCTACAGCATG	0.433000													7	63					0	0	0.000157383	0	0
SZT2	23334	broad.mit.edu	37	1	43896717	43896717	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:43896717C>T	ENST00000562955.1	+	32	4701	c.4701C>T	c.(4699-4701)ccC>ccT	p.P1567P	SZT2_ENST00000372442.1_Silent_p.P725P	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1624						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						TGACTTTGCCCCTGGAAGTGG	0.617000													5	43					0	0	0.00116845	0	0
OR5V1	81696	broad.mit.edu	37	6	29323829	29323829	+	Silent	SNP	C	C	T	rs140570809		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:29323829C>T	ENST00000377154.1	-	4	443	c.144G>A	c.(142-144)acG>acA	p.T48T	OR5V1_ENST00000543825.1_Silent_p.T48T			Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V, member 1	48					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(3)|large_intestine(3)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						CAGTCACAGTCGTCAAGATAA	0.388000													16	168					0	0	0.00152264	0	0
PSG3	5671	broad.mit.edu	37	19	43233378	43233378	+	Silent	SNP	A	A	G			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:43233378A>G	ENST00000327495.5	-	5	1324	c.1140T>C	c.(1138-1140)ttT>ttC	p.F380F	PSG3_ENST00000595140.1_Silent_p.F380F	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	380	Ig-like C2-type 3.			Missing (in Ref. 9).	defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				TCTGGGGGATAAAGAGCTTTT	0.458000													20	179					0	0	0.00188189	0	0
GPR98	84059	broad.mit.edu	37	5	89949582	89949582	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:89949582C>T	ENST00000405460.2	+	20	4287	c.4191C>T	c.(4189-4191)tcC>tcT	p.S1397S		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1397					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity	p.S1397S(1)		NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGACACTTTCCCTTCATTATA	0.373000													5	24					0	0	0.000602214	0	0
LCA5	167691	broad.mit.edu	37	6	80223044	80223044	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:80223044G>A	ENST00000392959.1	-	4	1216	c.605C>T	c.(604-606)tCc>tTc	p.S202F	LCA5_ENST00000369846.4_Missense_Mutation_p.S202F|LCA5_ENST00000467898.2_Missense_Mutation_p.S202F	NM_181714.3	NP_859065.2	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	202					protein transport	cilium axoneme|microtubule basal body	protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	32		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		TTTCTGTAAGGAAAATTTTGT	0.378000													12	69					0	0	0.000978159	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				7	70					0	0	0.000157383	0	0
ARRDC1	92714	broad.mit.edu	37	9	140508858	140508858	+	Silent	SNP	C	C	T	rs113768660		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr9:140508858C>T	ENST00000371421.4	+	6	790	c.726C>T	c.(724-726)atC>atT	p.I242I	ARRDC1_ENST00000491911.1_3'UTR	NM_152285.2	NP_689498.1	Q8N5I2	ARRD1_HUMAN	arrestin domain containing 1	242										breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|urinary_tract(1)	13	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000273)|Epithelial(140;0.000464)		ACGAGCAGATCCTGGTGCCTG	0.657000													10	68					0	0	0.000673444	0	0
MYH6	4624	broad.mit.edu	37	14	23863388	23863388	+	Silent	SNP	G	G	A	rs148596692		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:23863388G>A	ENST00000405093.3	-	21	2644	c.2574C>T	c.(2572-2574)ttC>ttT	p.F858F	MYH6_ENST00000356287.3_Silent_p.F858F	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	858					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TGATGCGCCCGAACTCTTCCT	0.572000													10	70					0	0	0.000978159	0	0
AMICA1	120425	broad.mit.edu	37	11	118074365	118074365	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:118074365G>A	ENST00000292067.7	-	5	961	c.520C>T	c.(520-522)Cgt>Tgt	p.R174C	AMICA1_ENST00000533261.1_Missense_Mutation_p.R173C|AMICA1_ENST00000356289.5_Missense_Mutation_p.R184C|AMICA1_ENST00000526620.1_Missense_Mutation_p.R145C	NM_153206.2	NP_694938.2	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen 1	184	Ig-like V-type 2.				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane		p.R174G(1)|p.R174C(1)		central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|stomach(2)	20	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		TGGTAGTAACGAAATACAATC	0.502000													5	43					0	0	0.00116845	0	0
HHLA2	11148	broad.mit.edu	37	3	108070690	108070690	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:108070690C>T	ENST00000467562.1	+	4	274	c.100C>T	c.(100-102)Cct>Tct	p.P34S	HHLA2_ENST00000357759.5_Silent_p.F10F|HHLA2_ENST00000489514.2_Silent_p.F10F|HHLA2_ENST00000491820.1_Silent_p.F10F|HHLA2_ENST00000467761.1_Silent_p.F10F			Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2	0						integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|ovary(1)	18						TGTCTTTCTTCCTCATTCTCA	0.358000													7	41					0	0	0.000274275	0	0
TAGAP	117289	broad.mit.edu	37	6	159457774	159457774	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:159457774G>A	ENST00000367066.3	-	10	1612	c.1281C>T	c.(1279-1281)ttC>ttT	p.F427F	TAGAP_ENST00000326965.6_Silent_p.F249F|RP1-111C20.4_ENST00000606466.1_RNA|RP1-111C20.4_ENST00000606470.1_RNA|RP1-111C20.4_ENST00000607796.1_RNA|RP1-111C20.4_ENST00000607391.1_RNA	NM_054114.3	NP_473455.2	Q8N103	TAGAP_HUMAN	T-cell activation RhoGTPase activating protein	427					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(2)|skin(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		GCACTGCAGGGAAGACCTCCT	0.572000													12	59					0	0	0.00136819	0	0
SPACA1	81833	broad.mit.edu	37	6	88768451	88768451	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:88768451G>A	ENST00000237201.1	+	4	502	c.385G>A	c.(385-387)Gaa>Aaa	p.E129K		NM_030960.2	NP_112222.1	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1	129						integral to membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	20		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		ACCAATTTCAGAAAGTCTTGA	0.318000													9	49					0	0	0.000274275	0	0
SLC9A2	6549	broad.mit.edu	37	2	103300737	103300737	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:103300737G>A	ENST00000233969.2	+	5	1509	c.1367G>A	c.(1366-1368)cGg>cAg	p.R456Q		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	456						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						GTGTTTCCTCGGAAAAAATTG	0.433000													13	132					0	0	0.000308642	0	0
PPFIA2	8499	broad.mit.edu	37	12	81741500	81741500	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:81741500C>T	ENST00000550584.2	-	17	2339	c.2044G>A	c.(2044-2046)Gaa>Aaa	p.E682K	PPFIA2_ENST00000333447.7_Missense_Mutation_p.E664K|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000552948.1_Missense_Mutation_p.E682K|PPFIA2_ENST00000541570.2_Missense_Mutation_p.E249K|PPFIA2_ENST00000443686.3_Missense_Mutation_p.E583K|PPFIA2_ENST00000549396.1_Missense_Mutation_p.E682K|PPFIA2_ENST00000549325.1_Missense_Mutation_p.E664K|PPFIA2_ENST00000548586.1_Missense_Mutation_p.E682K|PPFIA2_ENST00000407050.4_Missense_Mutation_p.E608K|PPFIA2_ENST00000541017.1_5'UTR|PPFIA2_ENST00000550359.2_Missense_Mutation_p.E529K	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	608										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						ACTCTATTTTCAATTTCTTCA	0.418000													7	87					0	0	0.000274275	0	0
PPP4R1	9989	broad.mit.edu	37	18	9557295	9557295	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr18:9557295G>A	ENST00000400556.3	-	15	2187	c.2114C>T	c.(2113-2115)cCa>cTa	p.P705L	PPP4R1_ENST00000400555.3_Missense_Mutation_p.P688L	NM_001042388.2	NP_001035847.1	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	705					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			large_intestine(1)|skin(2)	3						ATTAAAAATTGGAACCAGATC	0.363000													28	226					0	0	0.000491102	0	0
HTR4	3360	broad.mit.edu	37	5	147889130	147889130	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:147889130G>A	ENST00000360693.3	-	6	1103	c.965C>T	c.(964-966)gCc>gTc	p.A322V	HTR4_ENST00000314512.6_Missense_Mutation_p.A322V|HTR4_ENST00000377888.3_Missense_Mutation_p.A322V|HTR4_ENST00000362016.2_Missense_Mutation_p.A336V|HTR4_ENST00000354217.2_Missense_Mutation_p.A322V|HTR4_ENST00000520514.1_Missense_Mutation_p.A322V|HTR4_ENST00000521530.1_Missense_Mutation_p.A322V|HTR4_ENST00000521735.1_Missense_Mutation_p.A322V|HTR4_ENST00000517929.1_Missense_Mutation_p.A322V	NM_001040173.2	NP_001035263.1	Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	322					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	GATGAGGAAGGCACGTCTAAA	0.502000													9	35					0	0	0.000274275	0	0
CCDC67	159989	broad.mit.edu	37	11	93088569	93088569	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:93088569T>C	ENST00000298050.3	+	3	162	c.62T>C	c.(61-63)tTa>tCa	p.L21S	CCDC67_ENST00000527307.1_Missense_Mutation_p.L21S|CCDC67_ENST00000530053.1_3'UTR	NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	21										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				CTTCAGGAATTAATGGAACAA	0.368000													16	75					0	0	0.00121646	0	0
SPATA18	132671	broad.mit.edu	37	4	52945947	52945947	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:52945947C>T	ENST00000295213.4	+	9	1591	c.1217C>T	c.(1216-1218)tCa>tTa	p.S406L	SPATA18_ENST00000419395.2_Missense_Mutation_p.S374L	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	406					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			CCCAAGATTTCATTCCCTCCT	0.438000													22	170					0	0	0.00047179	0	0
ZNF667	63934	broad.mit.edu	37	19	56952847	56952847	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:56952847T>C	ENST00000504904.3	-	7	2236	c.1517A>G	c.(1516-1518)aAg>aGg	p.K506R	ZNF667_ENST00000292069.6_Missense_Mutation_p.K506R|ZNF667_ENST00000342634.3_Missense_Mutation_p.K634R|ZNF667_ENST00000591790.1_3'UTR			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	506					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		GCTGAAGGCCTTCCCACACTG	0.463000													3	39					0	0	0.00024832	0	0
HYOU1	10525	broad.mit.edu	37	11	118922276	118922276	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:118922276C>T	ENST00000404233.3	-	13	1524	c.1400G>A	c.(1399-1401)cGg>cAg	p.R467Q	HYOU1_ENST00000525859.1_Missense_Mutation_p.R467Q|HYOU1_ENST00000529972.1_Missense_Mutation_p.R467Q|HYOU1_ENST00000543287.1_Missense_Mutation_p.R380Q	NM_001130991.1|NM_006389.3	NP_001124463.1|NP_006380.1	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1	467						endoplasmic reticulum lumen	ATP binding|protein binding	p.R467Q(1)		NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(10)|prostate(1)|skin(2)	33	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		GAAGAGTACCCGTTTATTGTG	0.537000													8	43					0	0	0.000157383	0	0
BRAF	673	broad.mit.edu	37	7	140453135	140453135	+	Silent	SNP	C	C	T	rs121913377		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:140453135C>T	ENST00000288602.6	-	15	1860	c.1800G>A	c.(1798-1800)gtG>gtA	p.V600V		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(36)|p.V600D(16)|p.V600_K601>E(12)|p.T599_R603>I(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.V600V(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	ATCGAGATTTCACTGTAGCTA	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				7	70					0	0	0.000157383	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42439446	42439446	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr15:42439446C>T	ENST00000397272.3	-	13	1392	c.1301G>A	c.(1300-1302)gGa>gAa	p.G434E	PLA2G4F_ENST00000382396.4_Missense_Mutation_p.G432E	NM_213600.3	NP_998765.3	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	432	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		GGACAAAGCTCCCATCTTACT	0.627000													9	24					0	0	0.000673444	0	0
BBS7	55212	broad.mit.edu	37	4	122766756	122766756	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:122766756G>A	ENST00000264499.4	-	11	1316	c.1133C>T	c.(1132-1134)tCc>tTc	p.S378F	BBS7_ENST00000506636.1_Missense_Mutation_p.S378F	NM_176824.2	NP_789794.1	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7	378					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						TATACCAAAGGAAGGTACTGC	0.348000									Bardet-Biedl syndrome				8	70					0	0	0.000274275	0	0
GRIA4	2893	broad.mit.edu	37	11	105623907	105623907	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:105623907G>A	ENST00000393127.2	+	4	894	c.448G>A	c.(448-450)Gaa>Aaa	p.E150K	GRIA4_ENST00000393125.2_Missense_Mutation_p.E150K|GRIA4_ENST00000530497.1_Missense_Mutation_p.E150K|GRIA4_ENST00000428631.2_Missense_Mutation_p.E150K|GRIA4_ENST00000282499.5_Missense_Mutation_p.E150K|GRIA4_ENST00000525187.1_Missense_Mutation_p.E150K	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	150					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	GGATCACTACGAATGGAACTG	0.443000													21	69					0	0	0.000295444	0	0
WSCD1	23302	broad.mit.edu	37	17	6023963	6023963	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:6023963G>A	ENST00000574946.1	+	9	2100	c.1710G>A	c.(1708-1710)agG>agA	p.R570R	WSCD1_ENST00000574232.1_Silent_p.R570R|WSCD1_ENST00000539421.1_Silent_p.R570R|WSCD1_ENST00000573634.1_Silent_p.R454R|WSCD1_ENST00000317744.5_Silent_p.R570R			Q658N2	WSCD1_HUMAN	WSC domain containing 1	570						integral to membrane	sulfotransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)	35						GGCTGCCCAGGGAGTATGTGC	0.652000													10	45					0	0	0.000978159	0	0
TRIM63	84676	broad.mit.edu	37	1	26384907	26384907	+	Missense_Mutation	SNP	C	C	T	rs61749355	byFrequency	TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:26384907C>T	ENST00000374272.3	-	5	943	c.805G>A	c.(805-807)Gag>Aag	p.E269K		NM_032588.3	NP_115977.2	Q969Q1	TRI63_HUMAN	tripartite motif containing 63, E3 ubiquitin protein ligase	269	COS.					cytoplasm|microtubule|nucleus	ligase activity|signal transducer activity|titin binding|zinc ion binding			kidney(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;0.000154)|all_lung(284;0.00021)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;9.15e-26)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000767)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CCCCCAGGCTCGTCCAGGGAC	0.552000													9	63					0	0	0.000274275	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	171433	171433	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:171433G>A	ENST00000283426.6	+	14	2906	c.2856G>A	c.(2854-2856)aaG>aaA	p.K952K		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	952	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		ACCTGCTCAAGGAGGCCAGCT	0.672000													5	25					0	0	0.000602214	0	0
TBC1D10A	83874	broad.mit.edu	37	22	30689645	30689645	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr22:30689645G>A	ENST00000215790.7	-	8	1209	c.1045C>T	c.(1045-1047)Cag>Tag	p.Q349*	RP1-130H16.18_ENST00000447976.1_Nonsense_Mutation_p.Q223*|TBC1D10A_ENST00000403362.1_Nonsense_Mutation_p.Q261*|TBC1D10A_ENST00000403477.3_Nonsense_Mutation_p.Q356*	NM_031937.2	NP_114143.1	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	349						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						TGTACCTCCTGGACCAGAAAG	0.637000													5	34					0	0	8.12818e-05	0	0
BAZ2B	29994	broad.mit.edu	37	2	160294891	160294891	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:160294891G>A	ENST00000392783.2	-	8	1711	c.1216C>T	c.(1216-1218)Cct>Tct	p.P406S	BAZ2B_ENST00000392782.1_Missense_Mutation_p.P404S|BAZ2B_ENST00000355831.2_Missense_Mutation_p.P406S|BAZ2B_ENST00000343439.5_Missense_Mutation_p.P404S	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	406					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						AGAACATCAGGAGAAGGAACT	0.353000													7	48					0	0	8.12818e-05	0	0
STAB2	55576	broad.mit.edu	37	12	104111553	104111553	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:104111553C>T	ENST00000388887.2	+	44	4821	c.4617C>T	c.(4615-4617)gcC>gcT	p.A1539A		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1539	EGF-like 13.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GACAGGCTGCCTGTAACTGTT	0.507000													16	156					0	0	0.000566183	0	0
PENK	5179	broad.mit.edu	37	8	57354293	57354293	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:57354293C>T	ENST00000314922.3	-	2	418	c.342G>A	c.(340-342)atG>atA	p.M114I	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Missense_Mutation_p.M114I	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	114					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			AAAGCTCATCCATTTTCTTCA	0.498000													11	98					0	0	0.000673444	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	171434	171434	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:171434G>A	ENST00000283426.6	+	14	2907	c.2857G>A	c.(2857-2859)Gag>Aag	p.E953K		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	953	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CCTGCTCAAGGAGGCCAGCTG	0.677000													5	25					0	0	0.000602214	0	0
FAM171B	165215	broad.mit.edu	37	2	187605078	187605078	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:187605078G>A	ENST00000304698.5	+	2	565	c.362G>A	c.(361-363)gGa>gAa	p.G121E		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	121						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						AAAAGCAATGGAGCAGTGCTG	0.408000													6	61					0	0	0.00116845	0	0
PTH2R	5746	broad.mit.edu	37	2	209292968	209292968	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:209292968C>T	ENST00000272847.2	+	2	331	c.118C>T	c.(118-120)Ctt>Ttt	p.L40F	PTH2R_ENST00000413482.1_3'UTR	NM_005048.2	NP_005039.1	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor	40						integral to plasma membrane	parathyroid hormone receptor activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(21)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		GCAGATTGTCCTTGTGCTGAA	0.418000													7	46					0	0	0.000442599	0	0
PLG	5340	broad.mit.edu	37	6	161160173	161160173	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:161160173G>A	ENST00000308192.9	+	16	2014	c.1951G>A	c.(1951-1953)Gaa>Aaa	p.E651K		NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	651	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GCATGTTCAGGAAATAGAAGT	0.498000													12	77					0	0	0.000978159	0	0
CEP128	145508	broad.mit.edu	37	14	81302605	81302605	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:81302605G>A	ENST00000555265.1	-	12	1376	c.1001C>T	c.(1000-1002)tCc>tTc	p.S334F	CEP128_ENST00000216517.6_Missense_Mutation_p.S334F|CEP128_ENST00000281129.3_Missense_Mutation_p.S334F			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	334						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						CTGTTGCTTGGAAATCTGAGA	0.403000													26	100					0	0	0.000878237	0	0
BCAM	4059	broad.mit.edu	37	19	45315759	45315759	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:45315759C>T	ENST00000391955.1	+	4	502	c.458C>T	c.(457-459)tCc>tTc	p.S153F	BCAM_ENST00000270233.6_Missense_Mutation_p.S153F			P50895	BCAM_HUMAN	basal cell adhesion molecule (Lutheran blood group)	153	Ig-like V-type 2.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				ACTGAGGTCTCCCCCAACAAA	0.652000													28	187					0	0	0.001512	0	0
TRIM42	287015	broad.mit.edu	37	3	140397075	140397075	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:140397075G>A	ENST00000286349.3	+	1	195	c.4G>A	c.(4-6)Gaa>Aaa	p.E2K		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	2						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						AGGCACCATGGAAACTGCTAT	0.512000													20	99					0	0	0.000958276	0	0
KIF5A	3798	broad.mit.edu	37	12	57969485	57969485	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:57969485C>T	ENST00000455537.2	+	17	2242	c.1968C>T	c.(1966-1968)caC>caT	p.H656H	KIF5A_ENST00000286452.5_Silent_p.H567H	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	656					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						AGAAGCGGCACCTGGAAGAGT	0.557000													17	137					0	0	0.00121646	0	0
ZNF382	84911	broad.mit.edu	37	19	37101568	37101568	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:37101568G>A	ENST00000435416.1	+	2	1651	c.156G>A	c.(154-156)aaG>aaA	p.K52K	ZNF382_ENST00000423582.1_Silent_p.K3K|ZNF382_ENST00000439428.1_Silent_p.K51K|ZNF382_ENST00000292928.2_Silent_p.K52K			Q96SR6	ZN382_HUMAN	zinc finger protein 382	52	KRAB.|Mediates interaction with TRIM28 (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	34	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			ACATGGCTAAGCCTGATATGA	0.378000													10	80					0	0	0.00136819	0	0
TRIT1	54802	broad.mit.edu	37	1	40312932	40312932	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:40312932G>A	ENST00000316891.5	-	8	980	c.966C>T	c.(964-966)gcC>gcT	p.A322A	TRIT1_ENST00000372818.1_Intron|TRIT1_ENST00000441669.2_Silent_p.A240A|TRIT1_ENST00000545233.1_Silent_p.A76A|TRIT1_ENST00000491865.1_5'UTR|TRIT1_ENST00000541099.1_Intron|TRIT1_ENST00000537223.1_Silent_p.A18A|TRIT1_ENST00000537440.1_Silent_p.A18A	NM_017646.4	NP_060116.2	Q9H3H1	MOD5_HUMAN	tRNA isopentenyltransferase 1	322	Interaction with substrate tRNA (By similarity).				tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			breast(1)|large_intestine(5)|liver(1)|lung(3)|ovary(2)|pancreas(1)|stomach(1)|urinary_tract(1)	15	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TTTGTTTCCGGGCATATCTCT	0.393000													6	49					0	0	0.000157383	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593025	96593025	+	Missense_Mutation	SNP	C	C	T	rs75189823	by1000genomes	TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:96593025C>T	ENST00000456556.1	-	28	1960	c.1876G>A	c.(1876-1878)Gat>Aat	p.D626N						ankyrin repeat domain 36C									p.D626N(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TCTTTCTCATCACTTGTAGCC	0.318000													5	42					0	0	0.000602214	0	0
HCRTR2	3062	broad.mit.edu	37	6	55039521	55039521	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:55039521G>A	ENST00000370862.3	+	1	472	c.136G>A	c.(136-138)Gaa>Aaa	p.E46K		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	46					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CCTGTGGAGGGAATACCTGCA	0.537000													12	65					0	0	0.00136819	0	0
CORIN	10699	broad.mit.edu	37	4	47647134	47647134	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:47647134G>A	ENST00000273857.4	-	14	1920	c.1921C>T	c.(1921-1923)Cca>Tca	p.P641S	CORIN_ENST00000502252.1_Missense_Mutation_p.P574S|CORIN_ENST00000505909.1_Missense_Mutation_p.P604S|CORIN_ENST00000508498.1_Missense_Mutation_p.P502S|CORIN_ENST00000504584.1_Missense_Mutation_p.P604S	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	641	LDL-receptor class A 6.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						GGGCAGTCTGGGAACCCATCG	0.388000													13	91					0	0	0.000422831	0	0
ELTD1	64123	broad.mit.edu	37	1	79392765	79392765	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:79392765C>T	ENST00000370742.3	-	8	952	c.889G>A	c.(889-891)Gtt>Att	p.V297I		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	297					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		ACAAATGCAACTGCAACATTG	0.274000													6	45					0	0	0.00116845	0	0
TNRC6A	27327	broad.mit.edu	37	16	24831512	24831512	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr16:24831512C>T	ENST00000395799.3	+	22	5262	c.5133C>T	c.(5131-5133)acC>acT	p.T1711T	TNRC6A_ENST00000315183.7_Silent_p.T1662T|TNRC6A_ENST00000432286.2_Silent_p.T189T	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1711	Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		TTACAAACACCTCTCTGGCTC	0.493000													8	100					0	0	0.000673444	0	0
NACA2	342538	broad.mit.edu	37	17	59668329	59668329	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:59668329C>T	ENST00000521764.1	-	1	234	c.213G>A	c.(211-213)cgG>cgA	p.R71R		NM_199290.3	NP_954984.1	Q9H009	NACA2_HUMAN	nascent polypeptide-associated complex alpha subunit 2	71	NAC-A/B.				protein transport	cytoplasm|nucleus		p.R71R(1)		large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	12	all_epithelial(1;3.12e-14)					TCTTTTCACTCCGACTCTGTT	0.463000													23	172					0	0	0.000375601	0	0
NLRP13	126204	broad.mit.edu	37	19	56410190	56410190	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:56410190C>T	ENST00000588751.1	-	10	2927	c.2903G>A	c.(2902-2904)gGa>gAa	p.G968E	NLRP13_ENST00000342929.3_Missense_Mutation_p.G968E			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	968							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TAGCTTCACTCCATCATCCTG	0.458000													9	76					0	0	0.000673444	0	0
PNMT	5409	broad.mit.edu	37	17	37826222	37826222	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:37826222G>A	ENST00000269582.2	+	3	747	c.429G>A	c.(427-429)aaG>aaA	p.K143K	PNMT_ENST00000581428.1_3'UTR|PNMT_ENST00000394246.1_Silent_p.K45K	NM_002686.3	NP_002677.1	P11086	PNMT_HUMAN	phenylethanolamine N-methyltransferase	143					catecholamine biosynthetic process|hormone biosynthetic process	cytosol	phenylethanolamine N-methyltransferase activity			NS(1)|breast(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GGCAGGATAAGGAGCGCCAGC	0.657000													4	46					0	0	0.000602214	0	0
OSBP2	23762	broad.mit.edu	37	22	31289498	31289498	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr22:31289498G>A	ENST00000332585.6	+	10	2143	c.2039G>A	c.(2038-2040)aGg>aAg	p.R680K	OSBP2_ENST00000401475.1_Missense_Mutation_p.R313K|OSBP2_ENST00000535268.1_Missense_Mutation_p.R224K|OSBP2_ENST00000446658.2_Missense_Mutation_p.R679K|OSBP2_ENST00000403222.3_Missense_Mutation_p.R514K|OSBP2_ENST00000407373.1_Missense_Mutation_p.R507K|OSBP2_ENST00000382310.3_Missense_Mutation_p.R631K|OSBP2_ENST00000437268.2_Missense_Mutation_p.R422K|OSBP2_ENST00000496575.1_3'UTR	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	680					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						TACGTGTGGAGGAAGAGCACC	0.632000													9	56					0	0	0.000442599	0	0
RREB1	6239	broad.mit.edu	37	6	7248820	7248820	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:7248820C>T	ENST00000379938.2	+	13	5385	c.4848C>T	c.(4846-4848)atC>atT	p.I1616I	RREB1_ENST00000334984.6_Silent_p.I1350I|RREB1_ENST00000349384.6_Silent_p.I1561I|RREB1_ENST00000379933.3_Silent_p.I1561I	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	1561					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				ACCAGCGGATCCACCAGAAAG	0.557000													5	30					0	0	0.000602214	0	0
ZNF280A	129025	broad.mit.edu	37	22	22868501	22868501	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr22:22868501C>T	ENST00000302097.3	-	2	1706	c.1454G>A	c.(1453-1455)gGg>gAg	p.G485E		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	485					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		ACGAGGGAACCCTTGCAGTTG	0.438000													14	73					0	0	0.000422831	0	0
TRIM17	51127	broad.mit.edu	37	1	228596831	228596831	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:228596831G>A	ENST00000456946.2	-	6	1300	c.925C>T	c.(925-927)Ctt>Ttt	p.L309F	TRIM17_ENST00000366697.2_Intron|TRIM17_ENST00000366698.2_Intron|TRIM17_ENST00000295033.3_Intron|RP11-245P10.4_ENST00000436779.1_RNA	NM_001134855.1	NP_001128327.1	Q9Y577	TRI17_HUMAN	tripartite motif containing 17	0	B30.2/SPRY.				protein autoubiquitination	intracellular	protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)	10		Prostate(94;0.0724)				GCATCGCCAAGAGATCCTGGG	0.592000													8	50					0	0	0.000274275	0	0
POT1	25913	broad.mit.edu	37	7	124469352	124469352	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:124469352G>A	ENST00000357628.3	-	16	2148	c.1550C>T	c.(1549-1551)tCc>tTc	p.S517F	POT1_ENST00000393329.1_Missense_Mutation_p.S386F	NM_015450.2	NP_056265.2	Q9NUX5	POTE1_HUMAN	protection of telomeres 1	517					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47						ATCAACCAGGGAATTTAGATT	0.303000													6	85					0	0	0.000157383	0	0
MRAS	22808	broad.mit.edu	37	3	138091750	138091750	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:138091750G>A	ENST00000289104.4	+	2	672	c.25G>A	c.(25-27)Gac>Aac	p.D9N	MRAS_ENST00000464896.1_Intron|MRAS_ENST00000474559.1_Missense_Mutation_p.D9N|MRAS_ENST00000423968.2_Missense_Mutation_p.D9N	NM_001085049.2|NM_001252090.1|NM_001252091.1|NM_012219.4	NP_001078518.1|NP_001239019.1|NP_001239020.1|NP_036351.3	O14807	RASM_HUMAN	muscle RAS oncogene homolog	9					actin cytoskeleton organization|muscle organ development|Ras protein signal transduction	intracellular|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity			kidney(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	14						CGTCCCCAGTGACAACCTCCC	0.527000													35	215					0	0	0.000692331	0	0
SELE	6401	broad.mit.edu	37	1	169698654	169698654	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:169698654C>T	ENST00000333360.7	-	6	1015	c.876G>A	c.(874-876)tgG>tgA	p.W292*	SELE_ENST00000367776.1_Nonsense_Mutation_p.W292*|SELE_ENST00000367782.4_Nonsense_Mutation_p.W292*|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367780.4_Nonsense_Mutation_p.W230*|SELE_ENST00000367774.1_Nonsense_Mutation_p.W292*|SELE_ENST00000367779.4_Nonsense_Mutation_p.W292*|SELE_ENST00000367777.1_Nonsense_Mutation_p.W292*|SELE_ENST00000367775.1_Nonsense_Mutation_p.W230*|SELE_ENST00000367781.4_Nonsense_Mutation_p.W292*	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	292	Sushi 2.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					TCTCGTTGTCCCAATTCCCAG	0.453000													5	82					0	0	0.00116845	0	0
PPM1H	57460	broad.mit.edu	37	12	63114014	63114014	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:63114014C>T	ENST00000228705.6	-	6	1310	c.1010G>A	c.(1009-1011)aGg>aAg	p.R337K	PPM1H_ENST00000551214.1_5'UTR	NM_020700.1	NP_065751.1	Q9ULR3	PPM1H_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1H	337	PP2C-like.						phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)	18			GBM - Glioblastoma multiforme(1;0.000443)|BRCA - Breast invasive adenocarcinoma(9;0.209)	GBM - Glioblastoma multiforme(28;0.0126)		CTGTACTCTCCTTGGAAACTC	0.428000													14	133					0	0	0.000422831	0	0
FAM92B	339145	broad.mit.edu	37	16	85141674	85141674	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr16:85141674G>A	ENST00000539556.1	-	3	442	c.287C>T	c.(286-288)cCc>cTc	p.P96L		NM_198491.1	NP_940893.1	Q6ZTR7	FA92B_HUMAN	family with sequence similarity 92, member B	96										breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	16						GAGCTTCAGGGGGTTGACCAC	0.642000													11	37					0	0	0.000978159	0	0
ALDH7A1	501	broad.mit.edu	37	5	125906538	125906538	+	Missense_Mutation	SNP	C	C	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:125906538C>A	ENST00000409134.3	-	8	928	c.709G>T	c.(709-711)Gtt>Ttt	p.V237F	ALDH7A1_ENST00000413020.1_5'UTR|ALDH7A1_ENST00000553117.1_Missense_Mutation_p.V237F|ALDH7A1_ENST00000447989.2_Missense_Mutation_p.V264F	NM_001182.4|NM_001201377.1	NP_001173.2|NP_001188306.1	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	237					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			endometrium(1)|kidney(4)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	TCCTCCAGAACCTTGGCTATT	0.408000													18	147					1.00905e-13	5.1704e-13	0.00121646	1	0
BAI3	577	broad.mit.edu	37	6	69703712	69703712	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:69703712C>T	ENST00000370598.1	+	11	2608	c.1787C>T	c.(1786-1788)tCc>tTc	p.S596F		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	596					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GATGGAATGTCCCAGGTGACC	0.438000													32	201					0	0	0.00058488	0	0
PRDX5	25824	broad.mit.edu	37	11	64087253	64087253	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:64087253G>A	ENST00000265462.4	+	2	347	c.219G>A	c.(217-219)ggG>ggA	p.G73G	PRDX5_ENST00000352435.4_Silent_p.G73G|PRDX5_ENST00000347941.4_Intron	NM_012094.4	NP_036226.1	P30044	PRDX5_HUMAN	peroxiredoxin 5	73	Thioredoxin.				cell redox homeostasis|cellular response to reactive oxygen species|inflammatory response|negative regulation of apoptosis	cytosolic part|mitochondrion|peroxisome	caspase inhibitor activity|peroxidase activity|peroxiredoxin activity			breast(1)|kidney(1)|lung(1)|skin(1)	4					Auranofin(DB00995)	GGGAGCCAGGGAACAAGGTGA	0.597000													11	86					0	0	0.000219431	0	0
TMEM71	137835	broad.mit.edu	37	8	133740055	133740055	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:133740055G>A	ENST00000356838.3	-	6	750	c.608C>T	c.(607-609)tCg>tTg	p.S203L	TMEM71_ENST00000523829.1_Missense_Mutation_p.S222L|TMEM71_ENST00000377901.4_Intron	NM_144649.2	NP_653250.2	Q6P5X7	TMM71_HUMAN	transmembrane protein 71	222						integral to membrane				endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TGAATGATCCGAACTATTCTC	0.438000													10	108					0	0	0.000442599	0	0
LILRB4	11006	broad.mit.edu	37	19	55175697	55175697	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:55175697G>A	ENST00000391736.1	+	6	731	c.416G>A	c.(415-417)aGc>aAc	p.S139N	LILRB4_ENST00000430952.2_Missense_Mutation_p.S139N|LILRB4_ENST00000391734.3_Missense_Mutation_p.S139N|LILRB4_ENST00000270452.2_Missense_Mutation_p.S139N|LILRB4_ENST00000391733.3_Missense_Mutation_p.S139N	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	139	Ig-like C2-type 2.					integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		TCAGGAAAGAGCGTGACCCTG	0.572000													16	54					0	0	0.000308642	0	0
DIXDC1	85458	broad.mit.edu	37	11	111855995	111855995	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:111855995G>A	ENST00000440460.2	+	9	1252	c.955G>A	c.(955-957)Gag>Aag	p.E319K	DIXDC1_ENST00000389821.4_3'UTR|DIXDC1_ENST00000315253.5_Missense_Mutation_p.E108K	NM_001037954.2	NP_001033043.1	Q155Q3	DIXC1_HUMAN	DIX domain containing 1	320					multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	17		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		AGATGAACAGGAGAGGCCCTT	0.443000													4	16					0	0	0.000602214	0	0
PGC	5225	broad.mit.edu	37	6	41704688	41704688	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:41704688C>T	ENST00000373025.3	-	9	1131	c.1069G>A	c.(1069-1071)Ggc>Agc	p.G357S		NM_002630.3	NP_002621.1	P20142	PEPC_HUMAN	progastricsin (pepsinogen C)	357					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|skin(1)	16	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			AGGGGCTGGCCGTTCTGGGAG	0.557000													8	52					0	0	0.000442599	0	0
OR8A1	390275	broad.mit.edu	37	11	124440858	124440858	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:124440858C>T	ENST00000284287.3	+	1	966	c.894C>T	c.(892-894)atC>atT	p.I298I		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		CCACGGTAATCCCCATGTTGA	0.448000													7	30					0	0	0.000157383	0	0
CHST4	10164	broad.mit.edu	37	16	71570929	71570929	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr16:71570929C>T	ENST00000338482.5	+	3	692	c.349C>T	c.(349-351)Ccc>Tcc	p.P117S	CHST4_ENST00000539698.3_Missense_Mutation_p.P117S|RP11-510M2.9_ENST00000572693.1_RNA|CHST4_ENST00000572450.1_Missense_Mutation_p.P117S|ZNF19_ENST00000568446.1_Intron			Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4	117					cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			cervix(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	21						GGAACCTGGTCCCCGGAGACA	0.592000													13	36					0	0	0.000219431	0	0
MIR99AHG	388815	broad.mit.edu	37	21	17566918	17566918	+	RNA	SNP	C	C	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr21:17566918C>A	ENST00000458468.1	+	0	409					NR_027790.1																						CAGAAAATAGCACACTTTTAC	0.398000													8	45					4.68919e-08	2.39363e-07	0.000673444	1	0
POLE	5426	broad.mit.edu	37	12	133233953	133233953	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:133233953G>A	ENST00000320574.5	-	28	3484	c.3441C>T	c.(3439-3441)atC>atT	p.I1147I	POLE_ENST00000535270.1_Silent_p.I1120I	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	1147					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GGGCCGCAGGGATGGTGATGA	0.577000								DNA polymerases (catalytic subunits)					7	50					0	0	0.000157383	0	0
SALL3	27164	broad.mit.edu	37	18	76752127	76752127	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr18:76752127G>A	ENST00000575389.2	+	2	136	c.136G>A	c.(136-138)Ggg>Agg	p.G46R	SALL3_ENST00000536229.3_5'UTR|SALL3_ENST00000572928.1_3'UTR|SALL3_ENST00000537592.2_Missense_Mutation_p.G46R			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	46					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GAGCCGCAGCGGGGGCGAGGA	0.706000													4	13					0	0	0.00024832	0	0
ZNF662	389114	broad.mit.edu	37	3	42956557	42956557	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:42956557C>T	ENST00000541208.1	+	5	1361	c.992C>T	c.(991-993)cCt>cTt	p.P331L	KRBOX1_ENST00000426937.1_Intron|ZNF662_ENST00000422021.1_Intron|ZNF662_ENST00000328199.6_Missense_Mutation_p.P357L|ZNF662_ENST00000440367.2_Missense_Mutation_p.P331L			Q6ZS27	ZN662_HUMAN	zinc finger protein 662	331					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|large_intestine(6)|lung(5)|upper_aerodigestive_tract(1)	15				KIRC - Kidney renal clear cell carcinoma(284;0.217)		GGGGAGAAGCCTTACGAATGT	0.493000													5	39					0	0	0.00116845	0	0
OR1E1	8387	broad.mit.edu	37	17	3301630	3301630	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:3301630G>A	ENST00000322608.2	-	1	74	c.75C>T	c.(73-75)aaC>aaT	p.N25N		NM_003553.2	NP_003544.2	P30953	OR1E1_HUMAN	olfactory receptor, family 1, subfamily E, member 1	25					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(2)|lung(5)	10						CATAGCACAGGTTTTGCTGCT	0.517000													11	73					0	0	0.000219431	0	0
HAO2	51179	broad.mit.edu	37	1	119936434	119936434	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:119936434C>T	ENST00000361035.4	+	9	1349	c.1066C>T	c.(1066-1068)Cga>Tga	p.R356*	HAO2_ENST00000325945.3_Nonsense_Mutation_p.R343*|HAO2_ENST00000482991.1_3'UTR	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	343					fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		TGAGATCAATCGAAACTTGGT	0.478000													17	116					0	0	0.00074312	0	0
CELF3	11189	broad.mit.edu	37	1	151677575	151677575	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:151677575C>T	ENST00000290583.4	-	12	2133	c.1340G>A	c.(1339-1341)gGc>gAc	p.G447D	RP11-98D18.1_ENST00000457548.1_RNA|CELF3_ENST00000290585.4_Missense_Mutation_p.G397D|CELF3_ENST00000470688.1_5'UTR|CELF3_ENST00000392706.3_Missense_Mutation_p.G242D	NM_001172648.1|NM_007185.4	NP_001166119.1|NP_009116.3	Q5SZQ8	CELF3_HUMAN	CUGBP, Elav-like family member 3	447	RRM 3.				nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding	p.G447D(1)		central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	21						GCGCTTCATGCCGATCTGGAA	0.642000													8	45					0	0	0.000157383	0	0
MYO15A	51168	broad.mit.edu	37	17	18029750	18029750	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:18029750G>A	ENST00000205890.5	+	5	4184	c.3846G>A	c.(3844-3846)cgG>cgA	p.R1282R		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	1282	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					ACAACGGACGGGCCCTGGGAG	0.627000													5	34					0	0	0.000602214	0	0
CD164L2	388611	broad.mit.edu	37	1	27709047	27709047	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:27709047C>T	ENST00000374027.3	-	2	262	c.199G>A	c.(199-201)Gac>Aac	p.D67N	CD164L2_ENST00000374025.3_Missense_Mutation_p.D67N|CD164L2_ENST00000374030.1_Missense_Mutation_p.D67N	NM_207397.2	NP_997280.1	Q6UWJ8	C16L2_HUMAN	CD164 sialomucin-like 2	67						integral to membrane				endometrium(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CGCGCTCTGTCTCCCTCCACG	0.642000													8	32					0	0	0.000274275	0	0
MOGAT3	346606	broad.mit.edu	37	7	100844110	100844110	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:100844110G>A	ENST00000223114.4	-	1	192	c.26C>T	c.(25-27)cCc>cTc	p.P9L	MOGAT3_ENST00000379423.3_Missense_Mutation_p.P9L|MOGAT3_ENST00000440203.2_Missense_Mutation_p.P9L	NM_178176.2	NP_835470.1	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	9					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(3)	22	Lung NSC(181;0.168)|all_lung(186;0.215)					AGTGGTTGGGGGCTGCAGGGT	0.567000													7	21					0	0	0.000442599	0	0
MYH6	4624	broad.mit.edu	37	14	23865537	23865537	+	Silent	SNP	C	C	G			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr14:23865537C>G	ENST00000405093.3	-	20	2455	c.2385G>C	c.(2383-2385)cgG>cgC	p.R795R	MYH6_ENST00000356287.3_Silent_p.R795R	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	795	IQ.		R -> Q (in CMH14; late onset).		adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TGAGCTGGCCCCGGGCTTGGG	0.587000													8	49					0	0	0.000157383	0	0
PRTG	283659	broad.mit.edu	37	15	55930818	55930818	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr15:55930818G>A	ENST00000389286.4	-	14	2428	c.2381C>T	c.(2380-2382)gCc>gTc	p.A794V		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	794	Fibronectin type-III 4.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TAATCGAACGGCAAATTCGTA	0.388000													10	55					0	0	0.000442599	0	0
PODN	127435	broad.mit.edu	37	1	53542943	53542943	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:53542943C>T	ENST00000371500.3	+	8	1091	c.750C>T	c.(748-750)gtC>gtT	p.V250V	PODN_ENST00000395871.2_Intron|RP11-334A14.5_ENST00000447867.1_RNA|PODN_ENST00000312553.5_Silent_p.V269V	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	221					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						ACGTCGAGGTCCTCATCCTGT	0.632000													12	104					0	0	0.00136819	0	0
CXXC5	51523	broad.mit.edu	37	5	139060581	139060581	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:139060581G>A	ENST00000302517.3	+	2	1187	c.473G>A	c.(472-474)gGa>gAa	p.G158E	CXXC5_ENST00000511048.1_Missense_Mutation_p.G158E|CXXC5_ENST00000515038.1_3'UTR	NM_016463.7	NP_057547.5	Q7LFL8	CXXC5_HUMAN	CXXC finger protein 5	158					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|nucleus	DNA binding|signal transducer activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGCCGAGGGACAGCTGACG	0.632000													9	63					0	0	0.000274275	0	0
DGKG	1608	broad.mit.edu	37	3	186006576	186006576	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:186006576G>A	ENST00000265022.3	-	6	1006	c.467C>T	c.(466-468)tCc>tTc	p.S156F	DGKG_ENST00000382164.4_Missense_Mutation_p.S156F|DGKG_ENST00000344484.4_Missense_Mutation_p.S156F|DGKG_ENST00000544847.1_Missense_Mutation_p.S156F	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	156	Poly-Ser.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	TACCACTGGGGATTCCGAGCT	0.572000													18	197					0	0	0.000375601	0	0
OR4C11	219429	broad.mit.edu	37	11	55371070	55371070	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:55371070C>T	ENST00000302231.4	-	1	804	c.780G>A	c.(778-780)ccG>ccA	p.P260P		NM_001004700.2	NP_001004700.2	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C, member 11	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						GGAAAGTGGTCGGGGGGCGTG	0.438000													6	49					0	0	0.00116845	0	0
SACS	26278	broad.mit.edu	37	13	23904564	23904564	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr13:23904564G>A	ENST00000382298.3	-	10	14039	c.13451C>T	c.(13450-13452)gCt>gTt	p.A4484V	SACS_ENST00000402364.1_Missense_Mutation_p.A3734V|SACS_ENST00000382292.3_Missense_Mutation_p.A4484V	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	4484	HEPN.				cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TGCAATCAAAGCTAACTTGGT	0.408000													17	135					0	0	0.00074312	0	0
TTN	7273	broad.mit.edu	37	2	179418078	179418078	+	Missense_Mutation	SNP	A	A	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:179418078A>T	ENST00000589042.1	-	335	89773	c.89549T>A	c.(89548-89550)aTt>aAt	p.I29850N	TTN_ENST00000460472.2_Missense_Mutation_p.I20785N|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.I20977N|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.I28209N|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.I20910N|TTN_ENST00000342992.6_Missense_Mutation_p.I27282N|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000438095.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	28209	Fibronectin type-III 117.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCTTTGGCAATAACAGAAGT	0.403000													23	211					0	0	0.00188189	0	0
OR2W1	26692	broad.mit.edu	37	6	29012269	29012269	+	Silent	SNP	C	C	T	rs144276666		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:29012269C>T	ENST00000377175.1	-	1	748	c.684G>A	c.(682-684)acG>acA	p.T228T		NM_030903.3	NP_112165.1	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W, member 1	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T228T(1)		endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|skin(1)	23						CTTTTGACTTCGTTCTCAGCA	0.393000													11	93					0	0	0.00136819	0	0
TTN	7273	broad.mit.edu	37	2	179599144	179599144	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:179599144G>A	ENST00000589042.1	-	52	15631	c.15407C>T	c.(15406-15408)tCg>tTg	p.S5136L	TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.S4819L|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.S3892L|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4819	Ig-like 32.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTATTAAACGAAAAGATCTC	0.383000													41	176					0	0	0.000509022	0	0
NCKAP1	10787	broad.mit.edu	37	2	183795425	183795425	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:183795425G>A	ENST00000360982.2	-	28	3727	c.2969C>T	c.(2968-2970)tCg>tTg	p.S990L	NCKAP1_ENST00000361354.3_Missense_Mutation_p.S984L|NCKAP1_ENST00000478449.1_5'UTR	NM_205842.1	NP_995314.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1	984					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding	p.S990L(1)		breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			CATTTTACCCGATTTTTGTGA	0.353000													6	26					0	0	8.12818e-05	0	0
FGR	2268	broad.mit.edu	37	1	27943786	27943786	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:27943786C>T	ENST00000374005.3	-	6	738	c.450G>A	c.(448-450)ggG>ggA	p.G150G	FGR_ENST00000545953.1_Intron|FGR_ENST00000399173.1_Silent_p.G150G|FGR_ENST00000374004.1_Silent_p.G150G	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	150	SH2.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CATCCTTTCTCCCAATCTTTC	0.572000													8	43					0	0	0.000442599	0	0
ABCA4	24	broad.mit.edu	37	1	94520779	94520779	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:94520779C>T	ENST00000370225.3	-	16	2561	c.2475G>A	c.(2473-2475)ggG>ggA	p.G825G	ABCA4_ENST00000535735.1_Silent_p.G751G	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	825					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TGGGACTGTTCCCGATGTTGC	0.542000													7	52					0	0	0.000274275	0	0
ZNF532	55205	broad.mit.edu	37	18	56586307	56586307	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr18:56586307C>T	ENST00000336078.4	+	4	1564	c.788C>T	c.(787-789)tCg>tTg	p.S263L	ZNF532_ENST00000591808.1_Missense_Mutation_p.S263L|ZNF532_ENST00000591083.1_Missense_Mutation_p.S263L|ZNF532_ENST00000591230.1_Missense_Mutation_p.S263L|ZNF532_ENST00000589288.1_Missense_Mutation_p.S263L	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	263					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						AAGACAAAGTCGTCCTCCAAG	0.557000													8	44					0	0	0.000274275	0	0
VWA3B	200403	broad.mit.edu	37	2	98804438	98804438	+	Splice_Site	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:98804438G>A	ENST00000477737.1	+	10	1516	c.1311_splice	c.e10-1	p.E438_splice	VWA3B_ENST00000451075.2_Splice_Site_p.E288_splice|VWA3B_ENST00000435344.1_Splice_Site_p.E438_splice	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	438										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						ATCTCCTTAGGAGACGAACAA	0.483000													5	17					0	0	0.000157383	0	0
CD163L1	283316	broad.mit.edu	37	12	7585054	7585054	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:7585054G>A	ENST00000313599.3	-	4	781	c.724C>T	c.(724-726)Cat>Tat	p.H242Y	CD163L1_ENST00000396630.1_Missense_Mutation_p.H242Y|CD163L1_ENST00000416109.2_Missense_Mutation_p.H252Y			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	242	SRCR 2.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						CTGCAGTCATGATTTCCCCAT	0.423000													10	52					0	0	0.000673444	0	0
ZNF287	57336	broad.mit.edu	37	17	16469860	16469860	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:16469860C>T	ENST00000395824.1	-	3	1097	c.480G>A	c.(478-480)tgG>tgA	p.W160*	ZNF287_ENST00000395825.3_Nonsense_Mutation_p.W160*			Q9HBT7	ZN287_HUMAN	zinc finger protein 287	153					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|prostate(1)|urinary_tract(1)	20				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		AGTCATTTAGCCATCCTGTCT	0.443000													18	141					0	0	0.000958276	0	0
CSMD2	114784	broad.mit.edu	37	1	34015885	34015885	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:34015885C>T	ENST00000373381.4	-	56	8985	c.8809G>A	c.(8809-8811)Gga>Aga	p.G2937R		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2913	Sushi 21.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ACCACTGCTCCCACAGTATAA	0.592000													10	47					0	0	0.000673444	0	0
RUSC2	9853	broad.mit.edu	37	9	35559262	35559262	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr9:35559262C>T	ENST00000455600.1	+	9	3950	c.3381C>T	c.(3379-3381)aaC>aaT	p.N1127N		NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1127	RUN.					cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			ACCTCTATAACCACGAAGGTA	0.478000													4	41					0	0	0.000602214	0	0
OR10S1	219873	broad.mit.edu	37	11	123847469	123847469	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:123847469C>T	ENST00000531945.1	-	1	1019	c.930G>A	c.(928-930)aaG>aaA	p.K310K		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GCAGAGCATGCTTCACCTCCT	0.527000													8	47					0	0	0.000442599	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798623	55798623	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:55798623C>T	ENST00000313555.1	+	1	729	c.729C>T	c.(727-729)tcC>tcT	p.S243S		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					CTTGTGCTTCCCACCTCATAG	0.448000													20	131					0	0	0.00152264	0	0
PPP1R32	220004	broad.mit.edu	37	11	61254516	61254516	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:61254516G>A	ENST00000338608.2	+	10	1056	c.931G>A	c.(931-933)Gag>Aag	p.E311K	PPP1R32_ENST00000432063.2_Missense_Mutation_p.E291K	NM_145017.2	NP_659454.2	Q7Z5V6	CK066_HUMAN	protein phosphatase 1, regulatory subunit 32	311																	GCTTGGCCGGGAGACTGTGGG	0.582000													17	105					0	0	0.000566183	0	0
RP1	6101	broad.mit.edu	37	8	55540655	55540655	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:55540655G>A	ENST00000220676.1	+	4	4361	c.4213G>A	c.(4213-4215)Gaa>Aaa	p.E1405K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1405					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTGCCTAAGTGAAAAAGAAGC	0.318000													12	51					0	0	0.00136819	0	0
DDX52	11056	broad.mit.edu	37	17	35988707	35988707	+	Missense_Mutation	SNP	C	C	T	rs146312035	byFrequency	TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:35988707C>T	ENST00000349699.2	-	6	800	c.757G>A	c.(757-759)Gag>Aag	p.E253K	DDX52_ENST00000394367.3_Missense_Mutation_p.E145K	NM_007010.3	NP_008941.2	Q9Y2R4	DDX52_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 52	253	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			biliary_tract(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(5)|ovary(1)|skin(3)	17		Breast(25;0.00637)|Ovarian(249;0.15)				TTTATTAACTCTCTGTGAATC	0.313000													7	71					0	0	0.000157383	0	0
ATP10D	57205	broad.mit.edu	37	4	47525090	47525090	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:47525090C>T	ENST00000273859.3	+	4	816	c.547C>T	c.(547-549)Ctc>Ttc	p.L183F	ATP10D_ENST00000504445.1_Missense_Mutation_p.L183F	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	183					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						CTTTATTCGCCTCTCCTGCAA	0.393000													11	66					0	0	0.00136819	0	0
IGF2	3481	broad.mit.edu	37	11	2156739	2156739	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:2156739C>T	ENST00000416167.2	-	2	1181	c.15G>A	c.(13-15)atG>atA	p.M5I	IGF2_ENST00000381392.1_Missense_Mutation_p.M5I|IGF2_ENST00000381406.4_Missense_Mutation_p.M5I|IGF2_ENST00000434045.2_Missense_Mutation_p.M61I|IGF2_ENST00000418738.2_Missense_Mutation_p.M5I|IGF2_ENST00000381395.1_Missense_Mutation_p.M5I|IGF2_ENST00000300632.5_Missense_Mutation_p.M5I|IGF2_ENST00000381389.1_Missense_Mutation_p.M5I|IGF2_ENST00000337883.6_Missense_Mutation_p.M5I			P01344	IGF2_HUMAN	insulin-like growth factor 2 (somatomedin A)	5					glucose metabolic process|ossification|phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling|positive regulation of activated T cell proliferation|positive regulation of cell division|positive regulation of glycogen (starch) synthase activity|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|skeletal system development	extracellular space	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|protein serine/threonine kinase activator activity|receptor activator activity			central_nervous_system(1)|kidney(1)|lung(1)|pancreas(1)|skin(1)|urinary_tract(1)	6		all_epithelial(84;5.04e-06)|Breast(177;0.000777)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.0179)|COAD - Colon adenocarcinoma(6;0.029)	BRCA - Breast invasive adenocarcinoma(625;1.09e-05)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		TCGACTTCCCCATTGGGATTC	0.637000													4	18					0	0	0.000602214	0	0
TAS2R43	259289	broad.mit.edu	37	12	11244805	11244805	+	Silent	SNP	A	A	T	rs149617536	by1000genomes	TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:11244805A>T	ENST00000531678.1	-	1	107	c.24T>A	c.(22-24)atT>atA	p.I8I	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_Intron	NM_176884.2	NP_795365.2	P59537	T2R43_HUMAN	taste receptor, type 2, member 43	8					detection of chemical stimulus involved in sensory perception of bitter taste	cilium membrane|motile cilium	bitter taste receptor activity			endometrium(1)|ovary(1)|prostate(2)|urinary_tract(1)	5			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		GACTGGAAAAAATGATGGGTA	0.378000													5	30					0	0	8.12818e-05	0	0
ERCC3	2071	broad.mit.edu	37	2	128047347	128047347	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:128047347G>A	ENST00000493187.2	-	5	846	c.383C>T	c.(382-384)cCc>cTc	p.P128L	ERCC3_ENST00000285398.2_Missense_Mutation_p.P192L			P19447	ERCC3_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 3	192					cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	31	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TCGGATCACGGGGTCCTGGAG	0.532000			"""Mis, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				19	81					0	0	0.00188189	0	0
PABPC3	5042	broad.mit.edu	37	13	25671984	25671984	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr13:25671984C>T	ENST00000281589.3	+	1	1685	c.1648C>T	c.(1648-1650)Cct>Tct	p.P550S		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	550	PABC.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		ATCTGCCCCTCCTCAAAAGCA	0.468000													14	99					0	0	0.000308642	0	0
CREBBP	1387	broad.mit.edu	37	16	3823809	3823809	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr16:3823809G>A	ENST00000262367.5	-	13	3215	c.2406C>T	c.(2404-2406)tcC>tcT	p.S802S	CREBBP_ENST00000382070.3_Silent_p.S764S	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	802					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TCGCCCCGCTGGATGACGGGA	0.607000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						7	57					0	0	0.000157383	0	0
IL36G	56300	broad.mit.edu	37	2	113742450	113742450	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:113742450G>A	ENST00000259205.4	+	5	403	c.334G>A	c.(334-336)Gag>Aag	p.E112K	IL36G_ENST00000376489.2_Missense_Mutation_p.E77K	NM_019618.2	NP_062564.1	Q9NZH8	IL36G_HUMAN	interleukin 36, gamma	112					cell-cell signaling	extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						TGGCCAACCCGAGCCCGTGAA	0.493000													25	121					0	0	0.00127121	0	0
CD244	51744	broad.mit.edu	37	1	160801166	160801166	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:160801166C>T	ENST00000368034.4	-	9	1246	c.1069G>A	c.(1069-1071)Gag>Aag	p.E357K	CD244_ENST00000368033.3_Missense_Mutation_p.E362K|CD244_ENST00000322302.7_Missense_Mutation_p.E265K	NM_001166663.1|NM_001166664.1|NM_016382.3	NP_001160135.1|NP_001160136.1|NP_057466.1	Q9BZW8	CD244_HUMAN	CD244 molecule, natural killer cell receptor 2B4	362					blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	18	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TTCTCCAGCTCTTTGCGGCTC	0.473000													11	116					0	0	0.000422831	0	0
ATP8B4	79895	broad.mit.edu	37	15	50152396	50152396	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr15:50152396G>A	ENST00000284509.6	-	28	3715	c.3574C>T	c.(3574-3576)Ctg>Ttg	p.L1192L	ATP8B4_ENST00000559829.1_Silent_p.L1192L	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	1192					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TTGACTCACAGTTTCACTGTT	0.403000													23	115					0	0	0.000878237	0	0
PTPRK	5796	broad.mit.edu	37	6	128561213	128561213	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:128561213C>T	ENST00000368227.3	-	5	1026	c.660G>A	c.(658-660)ggG>ggA	p.G220G	PTPRK_ENST00000368207.3_Silent_p.G220G|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368226.4_Silent_p.G220G|PTPRK_ENST00000368215.3_Silent_p.G220G|PTPRK_ENST00000368213.5_Silent_p.G220G|PTPRK_ENST00000532331.1_Silent_p.G220G|PTPRK_ENST00000368210.3_Silent_p.G220G			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	220	Ig-like C2-type.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		CAGCATCTCTCCCTGTGGCAA	0.443000													6	58					0	0	8.12818e-05	0	0
KIF5A	3798	broad.mit.edu	37	12	57969486	57969486	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:57969486C>T	ENST00000455537.2	+	17	2243	c.1969C>T	c.(1969-1971)Ctg>Ttg	p.L657L	KIF5A_ENST00000286452.5_Silent_p.L568L	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	657					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						GAAGCGGCACCTGGAAGAGTC	0.552000													17	139					0	0	0.00121646	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45566864	45566864	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr18:45566864C>T	ENST00000588982.1	-	3	1116	c.615G>A	c.(613-615)agG>agA	p.R205R	ZBTB7C_ENST00000332053.2_Silent_p.R205R|ZBTB7C_ENST00000535628.2_Silent_p.R205R|ZBTB7C_ENST00000590800.1_Silent_p.R205R|ZBTB7C_ENST00000586438.1_Silent_p.R205R			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	205						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						CAGGGAAGTCCCTGGGGGTGT	0.572000													12	66					0	0	0.00185496	0	0
DNAH10	196385	broad.mit.edu	37	12	124350550	124350550	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:124350550T>C	ENST00000409039.3	+	40	6768	c.6743T>C	c.(6742-6744)gTt>gCt	p.V2248A		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2248	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGTGGAATGGTTTATGTGGAT	0.333000													7	73					0	0	0.000274275	0	0
KLKB1	3818	broad.mit.edu	37	4	187159439	187159439	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:187159439G>A	ENST00000264690.6	+	6	705	c.518G>A	c.(517-519)gGa>gAa	p.G173E	KLKB1_ENST00000513864.1_Missense_Mutation_p.G173E	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	173	Apple 2.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		TACAGTCCCGGAGGAACACCT	0.458000													6	51					0	0	0.000157383	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94668540	94668540	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:94668540C>T	ENST00000260526.6	-	10	1070	c.888G>A	c.(886-888)agG>agA	p.R296R	ARHGAP29_ENST00000370217.3_Silent_p.R296R	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	296					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TTTCATTTTTCCTTCCAAGTA	0.294000													8	88					0	0	0.000274275	0	0
DUSP23	54935	broad.mit.edu	37	1	159751976	159751976	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:159751976C>T	ENST00000368107.1	+	2	399	c.301C>T	c.(301-303)Cgc>Tgc	p.R101C	DUSP23_ENST00000368109.1_Missense_Mutation_p.R101C|DUSP23_ENST00000368108.3_Missense_Mutation_p.R101C			Q9BVJ7	DUS23_HUMAN	dual specificity phosphatase 23	101	Tyrosine-protein phosphatase.					cytosol|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			lung(1)	1	all_hematologic(112;0.0537)					GGGCTTTGGCCGCACTGGCAC	0.617000													5	45					0	0	8.12818e-05	0	0
CD177	57126	broad.mit.edu	37	19	43858513	43858513	+	RNA	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:43858513C>T	ENST00000378009.4	+	0	390				CD177_ENST00000607517.1_RNA|CD177_ENST00000378012.2_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				TCGTTAACTCCCTCCCGCTTT	0.672000													5	54					0	0	0.00116845	0	0
VSIG10	54621	broad.mit.edu	37	12	118517355	118517355	+	Silent	SNP	A	A	G			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:118517355A>G	ENST00000359236.5	-	4	997	c.721T>C	c.(721-723)Ttg>Ctg	p.L241L		NM_019086.5	NP_061959.2	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	241	Ig-like C2-type 3.					integral to membrane				endometrium(5)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|urinary_tract(1)	17						GTAAGCTGCAACATGAACGAT	0.552000													14	65					0	0	0.000308642	0	0
EDN1	1906	broad.mit.edu	37	6	12296257	12296257	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:12296257C>T	ENST00000379375.5	+	5	863	c.596C>T	c.(595-597)cCc>cTc	p.P199L		NM_001168319.1|NM_001955.4	NP_001161791.1|NP_001946.3	P05305	EDN1_HUMAN	endothelin 1	199					artery smooth muscle contraction|calcium-mediated signaling|leukocyte activation|negative regulation of blood coagulation|negative regulation of cellular protein metabolic process|negative regulation of nitric-oxide synthase biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|nitric oxide transport|peptide hormone secretion|phosphatidylinositol 3-kinase cascade|positive regulation of cardiac muscle hypertrophy|positive regulation of cell size|positive regulation of endothelial cell migration|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of JUN kinase activity|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of sarcomere organization|positive regulation of smooth muscle cell proliferation|prostaglandin biosynthetic process|protein kinase C deactivation|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	cytoplasm|extracellular space	cytokine activity|endothelin A receptor binding|endothelin B receptor binding|hormone activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	13	all_cancers(95;0.241)|Breast(50;0.0266)|Ovarian(93;0.12)	all_hematologic(90;0.117)				AAAGGCAAGCCCTCCAGAGAG	0.488000													14	158					0	0	0.000422831	0	0
SERPINI2	5276	broad.mit.edu	37	3	167159941	167159941	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:167159941G>A	ENST00000476257.1	-	10	1472	c.1174C>T	c.(1174-1176)Cct>Tct	p.P392S	SERPINI2_ENST00000461846.1_Missense_Mutation_p.P392S|SERPINI2_ENST00000264677.4_Missense_Mutation_p.P392S|SERPINI2_ENST00000471111.1_Missense_Mutation_p.P392S			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	392					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						TGGGTGTCAGGATTTGTCACT	0.323000													7	28					0	0	0.000274275	0	0
BAGE2	85319	broad.mit.edu	37	21	11047514	11047514	+	RNA	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr21:11047514C>T	ENST00000470054.1	-	0	740									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTACAGATTTCATAATTCGTT	0.348000													8	385					0	0	0.000274275	0	0
CASS4	57091	broad.mit.edu	37	20	55028110	55028110	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr20:55028110C>T	ENST00000371336.3	+	5	2079	c.1878C>T	c.(1876-1878)acC>acT	p.T626T	CASS4_ENST00000360314.3_Silent_p.T626T|CASS4_ENST00000434344.1_Intron	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	626					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						AAAAGAGTACCCCTTCCACTA	0.413000													6	32					0	0	8.12818e-05	0	0
UNC13B	10497	broad.mit.edu	37	9	35382413	35382413	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr9:35382413C>T	ENST00000378495.3	+	20	2690	c.2468C>T	c.(2467-2469)aCc>aTc	p.T823I	UNC13B_ENST00000378496.4_Missense_Mutation_p.T823I|UNC13B_ENST00000396787.1_Missense_Mutation_p.T835I	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	823					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GTGATGAGCACCTTACTGGCC	0.502000													17	89					0	0	0.000566183	0	0
PTPN13	5783	broad.mit.edu	37	4	87684145	87684145	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:87684145C>T	ENST00000436978.1	+	24	4299	c.3819C>T	c.(3817-3819)acC>acT	p.T1273T	PTPN13_ENST00000427191.2_Silent_p.T1254T|PTPN13_ENST00000316707.6_Silent_p.T1082T|PTPN13_ENST00000411767.2_Silent_p.T1273T|PTPN13_ENST00000511467.1_Silent_p.T1273T	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	1273						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		GTGACCAAACCTGGCAGGAAT	0.478000													5	46					0	0	0.00116845	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	169640	169640	+	Missense_Mutation	SNP	A	A	C			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:169640A>C	ENST00000283426.6	+	12	2644	c.2594A>C	c.(2593-2595)cAc>cCc	p.H865P		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	865	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CACCAGCAGCACTTCCTCCGG	0.602000													7	94					0	0	8.12818e-05	0	0
PRDM9	56979	broad.mit.edu	37	5	23518034	23518034	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr5:23518034C>T	ENST00000296682.3	+	5	528	c.346C>T	c.(346-348)Cag>Tag	p.Q116*		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	116					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GCGTAAACACCAGAAGGTAAG	0.408000										HNSCC(3;0.000094)			16	110					0	0	0.000566183	0	0
ITGB4	3691	broad.mit.edu	37	17	73748645	73748645	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:73748645C>T	ENST00000200181.3	+	32	4282	c.4095C>T	c.(4093-4095)gtC>gtT	p.V1365V	ITGB4_ENST00000449880.2_Silent_p.V1365V|ITGB4_ENST00000339591.3_Silent_p.V1365V|GALK1_ENST00000225614.2_Intron|ITGB4_ENST00000579662.1_Silent_p.V1365V|ITGB4_ENST00000450894.3_Silent_p.V1365V	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	1365					cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGCCCAGCGTCTCCGATGACA	0.612000													5	56					0	0	0.00116845	0	0
ANGPTL2	23452	broad.mit.edu	37	9	129870958	129870958	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr9:129870958C>T	ENST00000373425.3	-	2	670	c.53G>A	c.(52-54)gGa>gAa	p.G18E	RALGPS1_ENST00000373434.1_Intron|RALGPS1_ENST00000259351.5_Intron|ANGPTL2_ENST00000373417.1_Intron|RALGPS1_ENST00000394022.3_Intron|RALGPS1_ENST00000424082.2_Intron|RALGPS1_ENST00000373436.1_Intron	NM_012098.2	NP_036230.1	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2	18					multicellular organismal development|signal transduction	extracellular space	receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|urinary_tract(1)	18						TGCAACAGCTCCCATGGCAGC	0.547000													6	26					0	0	8.12818e-05	0	0
EPHA7	2045	broad.mit.edu	37	6	93967959	93967959	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:93967959C>T	ENST00000369303.4	-	11	2152	c.1968G>A	c.(1966-1968)ggG>ggA	p.G656G		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	656	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CATCTCTTTTCCCTGGAAGTT	0.388000													18	120					0	0	0.00152264	0	0
HIVEP1	3096	broad.mit.edu	37	6	12121818	12121818	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:12121818A>G	ENST00000379388.2	+	4	2122	c.1790A>G	c.(1789-1791)cAg>cGg	p.Q597R		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	597					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AAGGACCTTCAGGTGACAAAC	0.507000													10	77					0	0	0.00185496	0	0
MUC16	94025	broad.mit.edu	37	19	9064628	9064628	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:9064628C>T	ENST00000397910.4	-	3	23021	c.22818G>A	c.(22816-22818)agG>agA	p.R7606R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7608	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGCAGAAATCCTGGGGATGG	0.478000													10	41					0	0	0.000673444	0	0
SLC2A14	144195	broad.mit.edu	37	12	7982503	7982503	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:7982503G>A	ENST00000543909.1	-	10	1200	c.441C>T	c.(439-441)ggC>ggT	p.G147G	SLC2A14_ENST00000535295.1_Silent_p.G38G|SLC2A14_ENST00000431042.2_Silent_p.G124G|SLC2A14_ENST00000542505.1_Intron|SLC2A14_ENST00000539924.1_Silent_p.G162G|SLC2A14_ENST00000542546.1_Silent_p.G38G|SLC2A14_ENST00000340749.5_Silent_p.G124G|SLC2A14_ENST00000396589.2_Silent_p.G147G			Q8TDB8	GTR14_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 14	147					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	38				Kidney(36;0.0883)		TAACCAAGCGGCCCAGGATCA	0.532000													7	31					0	0	0.000442599	0	0
PNPT1	87178	broad.mit.edu	37	2	55913524	55913524	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:55913524G>A	ENST00000447944.2	-	3	364	c.278C>T	c.(277-279)tCc>tTc	p.S93F		NM_033109.3	NP_149100.2	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	93					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CATAAACTGGGAAGGGGAAGG	0.378000													10	37					0	0	0.000978159	0	0
CHD5	26038	broad.mit.edu	37	1	6172219	6172219	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:6172219G>A	ENST00000262450.3	-	35	5220	c.5121C>T	c.(5119-5121)atC>atT	p.I1707I	CHD5_ENST00000378021.1_Silent_p.I564I	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1707					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CCCCGTCCGCGATGTTGAACA	0.517000													7	32					0	0	8.12818e-05	0	0
XKR6	286046	broad.mit.edu	37	8	10755821	10755821	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:10755821G>A	ENST00000416569.2	-	3	1593	c.1567C>T	c.(1567-1569)Ccc>Tcc	p.P523S	XKR6_ENST00000304437.2_Missense_Mutation_p.P244S	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	523						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		ACATCGGGGGGCAAAGGGATG	0.602000													7	29					0	0	0.000157383	0	0
VWA7	80737	broad.mit.edu	37	6	31742303	31742303	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:31742303C>T	ENST00000375686.3	-	5	948	c.711G>A	c.(709-711)ccG>ccA	p.P237P	VWA7_ENST00000447450.1_Silent_p.P237P|VWA7_ENST00000375688.4_Silent_p.P237P|VWA7_ENST00000467576.1_5'UTR	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	237						extracellular region											CTGGAGGTTTCGGGGGATGAG	0.542000													15	157					0	0	0.000566183	0	0
ZNF512B	57473	broad.mit.edu	37	20	62595261	62595261	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr20:62595261G>A	ENST00000450537.1	-	9	1546	c.1486C>T	c.(1486-1488)Cct>Tct	p.P496S	ZNF512B_ENST00000217130.3_Missense_Mutation_p.P496S|ZNF512B_ENST00000369888.1_Missense_Mutation_p.P496S			Q96KM6	Z512B_HUMAN	zinc finger protein 512B	496					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(4)|skin(1)	33	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					TGCTCTTCAGGGCCACCTGTG	0.652000													7	36					0	0	8.12818e-05	0	0
UGT2B7	7364	broad.mit.edu	37	4	69964304	69964304	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:69964304G>A	ENST00000305231.7	+	2	814	c.768G>A	c.(766-768)tgG>tgA	p.W256*	UGT2B7_ENST00000508661.1_Nonsense_Mutation_p.W256*|UGT2B7_ENST00000509763.1_3'UTR	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	256					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CTGACGTATGGCTTATTCGAA	0.408000													7	90					0	0	0.000442599	0	0
MZF1	7593	broad.mit.edu	37	19	59073677	59073677	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:59073677G>A	ENST00000215057.2	-	6	2527	c.1967C>T	c.(1966-1968)cCc>cTc	p.P656L	AC016629.8_ENST00000600726.1_RNA|AC016629.8_ENST00000593642.1_RNA|MZF1_ENST00000599369.1_Missense_Mutation_p.P656L|MZF1_ENST00000594234.1_3'UTR|AC016629.8_ENST00000600534.1_RNA	NM_001267033.1|NM_198055.1	NP_001253962.1|NP_932172.1	P28698	MZF1_HUMAN	myeloid zinc finger 1	656					viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		GCCGCACTCGGGGCAGGCGAA	0.692000													3	7					0	0	6.4e-05	0	0
ZEB2	9839	broad.mit.edu	37	2	145147437	145147437	+	Missense_Mutation	SNP	G	G	C			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:145147437G>C	ENST00000558170.2	-	10	4410	c.3226C>G	c.(3226-3228)Cac>Gac	p.H1076D	ZEB2_ENST00000303660.4_Missense_Mutation_p.H1076D|ZEB2_ENST00000539609.3_Missense_Mutation_p.H1052D|ZEB2_ENST00000409487.3_Missense_Mutation_p.H1076D	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	1076						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		GAATACCTGTGATTCATGTGC	0.592000													5	49					0	0	0.000602214	0	0
SPAG11B	10407	broad.mit.edu	37	8	7308681	7308681	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:7308681C>T	ENST00000297498.2	-	3	421	c.255G>A	c.(253-255)agG>agA	p.R85R	SPAG11B_ENST00000528168.1_Silent_p.R32R|SPAG11B_ENST00000359758.5_Intron|SPAG11B_ENST00000398462.2_Intron|SPAG11B_ENST00000458665.1_Intron|SPAG11B_ENST00000361111.2_Intron	NM_016512.3	NP_057596.1	Q08648	SG11B_HUMAN	sperm associated antigen 11B	85					spermatogenesis	extracellular region				large_intestine(2)|lung(3)|urinary_tract(1)	6				COAD - Colon adenocarcinoma(149;0.0162)|READ - Rectum adenocarcinoma(644;0.236)		CCACACAGATCCTAAATGAGG	0.463000													8	214					0	0	0.000274275	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54925472	54925472	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:54925472C>T	ENST00000474759.1	+	25	2289	c.2241C>T	c.(2239-2241)acC>acT	p.T747T	CACNA2D3_ENST00000490478.1_Silent_p.T653T|CACNA2D3-AS1_ENST00000471265.1_RNA|CACNA2D3_ENST00000288197.5_Silent_p.T747T|CACNA2D3_ENST00000415676.2_Silent_p.T747T	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	747						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		AGCAGCTCACCAATCAGTAAG	0.507000													11	29					0	0	0.000978159	0	0
RSPH6A	81492	broad.mit.edu	37	19	46307945	46307945	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:46307945G>A	ENST00000221538.3	-	3	1360	c.1218C>T	c.(1216-1218)tcC>tcT	p.S406S	RSPH6A_ENST00000597055.1_Silent_p.S406S|RSPH6A_ENST00000600188.1_Silent_p.S142S	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	406						intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						GCTTCCATACGGACTTAGGGA	0.647000													5	33					0	0	0.00116845	0	0
PCLO	27445	broad.mit.edu	37	7	82390062	82390062	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:82390062G>A	ENST00000333891.8	-	24	15518	c.15181C>T	c.(15181-15183)Caa>Taa	p.Q5061*		NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4984					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ACCTTTTTTTGGGTAGAAATA	0.303000													4	23					0	0	0.00024832	0	0
DNM3	26052	broad.mit.edu	37	1	172348277	172348277	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:172348277C>T	ENST00000358155.4	+	18	2189	c.2013C>T	c.(2011-2013)atC>atT	p.I671I	DNM3_ENST00000367731.1_Silent_p.I667I|DNM3_ENST00000355305.5_Silent_p.I677I	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	677	GED.				endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						ACAAATGTATCCGAGATCTAA	0.398000													5	24					0	0	0.00116845	0	0
CER1	9350	broad.mit.edu	37	9	14720112	14720112	+	Silent	SNP	G	G	A	rs142384565		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr9:14720112G>A	ENST00000380911.3	-	2	824	c.780C>T	c.(778-780)tcC>tcT	p.S260S		NM_005454.2	NP_005445.1	O95813	CER1_HUMAN	cerberus 1, DAN family BMP antagonist	260					BMP signaling pathway	extracellular space	cytokine activity			endometrium(2)|large_intestine(3)|lung(6)	11				GBM - Glioblastoma multiforme(50;3.16e-06)		CTGGGATAAAGGAATCCTGGG	0.468000													9	46					0	0	0.000673444	0	0
UGT2B28	54490	broad.mit.edu	37	4	70155457	70155457	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr4:70155457G>A	ENST00000335568.5	+	4	1079	c.1077G>A	c.(1075-1077)caG>caA	p.Q359Q	UGT2B28_ENST00000511240.1_Intron	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	359					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	GGATACCCCAGAATGACCTTC	0.353000													8	21					0	0	0.000274275	0	0
EAF2	55840	broad.mit.edu	37	3	121573544	121573544	+	Missense_Mutation	SNP	C	C	T	rs143406125		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr3:121573544C>T	ENST00000273668.2	+	3	283	c.212C>T	c.(211-213)cCa>cTa	p.P71L	EAF2_ENST00000451944.2_Missense_Mutation_p.P71L	NM_018456.4	NP_060926.2	Q96CJ1	EAF2_HUMAN	ELL associated factor 2	71	Necessary for interaction with ELL.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)	9				GBM - Glioblastoma multiforme(114;0.0972)		GGTTCAACTCCACCAGTAACT	0.323000													6	55					0	0	0.00116845	0	0
FFAR4	338557	broad.mit.edu	37	10	95347082	95347082	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr10:95347082C>T	ENST00000371483.4	+	4	906	c.850C>T	c.(850-852)Ctc>Ttc	p.L284F	FFAR4_ENST00000371481.4_Missense_Mutation_p.L268F|FFAR4_ENST00000604414.1_Intron	NM_181745.3	NP_859529.2			free fatty acid receptor 4																		CACCCTCTTCCTCCTCATGGT	0.567000													14	94					0	0	0.00185496	0	0
SAMHD1	25939	broad.mit.edu	37	20	35547838	35547838	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr20:35547838G>A	ENST00000262878.4	-	7	980	c.781C>T	c.(781-783)Cct>Tct	p.P261S	SAMHD1_ENST00000373694.5_Missense_Mutation_p.P46S	NM_015474.3	NP_056289.2	Q9Y3Z3	SAMH1_HUMAN	SAM domain and HD domain 1	261	HD.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	20		Myeloproliferative disorder(115;0.00878)				TCTTCTTCAGGGATGAGACCA	0.348000													15	63					0	0	0.000308642	0	0
ATG2A	23130	broad.mit.edu	37	11	64668062	64668062	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:64668062G>A	ENST00000421419.2	-	31	4488	c.4374C>T	c.(4372-4374)tcC>tcT	p.S1458S	ATG2A_ENST00000377264.3_Silent_p.S1456S			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1456							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						CAGAGCAGCGGGAAGGGGAGC	0.662000													4	42					0	0	0.00024832	0	0
CACNA1E	777	broad.mit.edu	37	1	181741317	181741317	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr1:181741317G>A	ENST00000526775.1	+	36	5197	c.5032G>A	c.(5032-5034)Gat>Aat	p.D1678N	CACNA1E_ENST00000367573.2_Missense_Mutation_p.D1697N|CACNA1E_ENST00000367570.1_Missense_Mutation_p.D1697N|CACNA1E_ENST00000367567.4_Missense_Mutation_p.D1304N|CACNA1E_ENST00000360108.3_Missense_Mutation_p.D1678N|CACNA1E_ENST00000357570.5_Missense_Mutation_p.D1648N|CACNA1E_ENST00000358338.5_Missense_Mutation_p.D1629N	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1697					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CTGCGGCACCGATCTGGCCTA	0.557000													9	88					0	0	0.000673444	0	0
ALPK2	115701	broad.mit.edu	37	18	56184319	56184319	+	Missense_Mutation	SNP	C	C	T	rs151328897		TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr18:56184319C>T	ENST00000361673.3	-	9	5974	c.5761G>A	c.(5761-5763)Gag>Aag	p.E1921K		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1921	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TGCAGCTCCTCCGTGGCGATC	0.547000													6	60					0	0	0.00116845	0	0
BRPF3	27154	broad.mit.edu	37	6	36168987	36168987	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:36168987C>T	ENST00000357641.6	+	2	1141	c.888C>T	c.(886-888)atC>atT	p.I296I	BRPF3_ENST00000443324.2_Silent_p.I296I|BRPF3_ENST00000534694.1_Silent_p.I296I|BRPF3_ENST00000534400.1_Silent_p.I296I|BRPF3_ENST00000543502.1_Silent_p.I296I|BRPF3_ENST00000339717.7_Silent_p.I296I	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	296					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						CCATCTGGATCCCTGAAGTCT	0.547000													8	61					0	0	0.000673444	0	0
EBF2	64641	broad.mit.edu	37	8	25708162	25708162	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr8:25708162G>A	ENST00000520164.1	-	15	2181	c.1644C>T	c.(1642-1644)ccC>ccT	p.P548P	EBF2_ENST00000408929.3_Silent_p.P400P|EBF2_ENST00000535548.1_3'UTR	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	548					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GGGAGCCTTGGGGCCTGATGA	0.522000													11	96					0	0	0.000978159	0	0
TENM4	26011	broad.mit.edu	37	11	78380468	78380468	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:78380468G>A	ENST00000278550.7	-	32	7384	c.6922C>T	c.(6922-6924)Cac>Tac	p.H2308Y		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		TGCAGGTGGTGGCTGTGGCTG	0.602000													12	76					0	0	0.00136819	0	0
CATSPERG	57828	broad.mit.edu	37	19	38858697	38858697	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:38858697C>T	ENST00000409235.3	+	26	3055	c.2940C>T	c.(2938-2940)agC>agT	p.S980S	CATSPERG_ENST00000410018.1_Silent_p.S940S|CATSPERG_ENST00000215069.4_3'UTR	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	980					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						GGACCAACAGCCTTATCTGGA	0.612000													5	71					0	0	0.00116845	0	0
OR56A3	390083	broad.mit.edu	37	11	5968762	5968762	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:5968762C>T	ENST00000329564.6	+	1	193	c.186C>T	c.(184-186)ccC>ccT	p.P62P		NM_001003443.2	NP_001003443.2	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A, member 3	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(27)|stomach(1)|upper_aerodigestive_tract(1)	41		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCACCAGCCCCTGTACTACC	0.612000													13	82					0	0	0.00136819	0	0
SCAF11	9169	broad.mit.edu	37	12	46320763	46320763	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr12:46320763G>A	ENST00000465950.1	-	1	2985	c.1776C>T	c.(1774-1776)tcC>tcT	p.S592S	SCAF11_ENST00000549162.1_Silent_p.S715S|SCAF11_ENST00000419565.2_Silent_p.S907S|SCAF11_ENST00000369367.3_Silent_p.S907S			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	907					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						TCTGGGACCTGGATTTTTCTC	0.453000													7	99					0	0	0.000274275	0	0
KIAA1841	84542	broad.mit.edu	37	2	61361297	61361297	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:61361297G>A	ENST00000295031.5	+	21	2431	c.2054G>A	c.(2053-2055)gGc>gAc	p.G685D		NM_032506.2	NP_115895.2	Q6NSI8	K1841_HUMAN	KIAA1841	0										breast(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	25			Epithelial(17;0.193)			cccagagacggcactgtgtct	0.403000													9	39					0	0	0.000442599	0	0
EPO	2056	broad.mit.edu	37	7	100320727	100320727	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:100320727G>A	ENST00000252723.2	+	5	734	c.553G>A	c.(553-555)Ggg>Agg	p.G185R		NM_000799.2	NP_000790.2	P01588	EPO_HUMAN	erythropoietin	185					blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)|endometrium(2)|lung(7)|prostate(1)	12	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	GCTGTACACAGGGGAGGCCTG	0.587000													6	59					0	0	8.12818e-05	0	0
GRM8	2918	broad.mit.edu	37	7	126086239	126086239	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr7:126086239C>T	ENST00000339582.2	-	10	3426	c.2618G>A	c.(2617-2619)gGa>gAa	p.G873E	GRM8_ENST00000444921.2_Missense_Mutation_p.G873E|GRM8_ENST00000358373.3_Missense_Mutation_p.G873E			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	873					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TCTGTCATTTCCTTTTTGGAT	0.438000										HNSCC(24;0.065)			21	120					0	0	0.00121646	0	0
ANKS1A	23294	broad.mit.edu	37	6	35046409	35046409	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:35046409C>T	ENST00000360359.3	+	14	2397	c.2259C>T	c.(2257-2259)ctC>ctT	p.L753L	ANKS1A_ENST00000535627.1_Intron|ANKS1A_ENST00000470698.1_3'UTR	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	753	SAM 1.					cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						GGAAGCTGCTCCAGGCGGCAC	0.647000													7	65					0	0	0.000442599	0	0
FRG1B	284802	broad.mit.edu	37	20	29632694	29632694	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr20:29632694G>A	ENST00000278882.3	+	8	889	c.509G>A	c.(508-510)gGa>gAa	p.G170E	FRG1B_ENST00000358464.4_Missense_Mutation_p.G170E																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						CAGAAAGATGGATTTTTGCAT	0.318000													14	848					0	0	0.000219431	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883592	228883592	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr2:228883592C>T	ENST00000392056.3	-	7	2024	c.1978G>A	c.(1978-1980)Gaa>Aaa	p.E660K	SPHKAP_ENST00000344657.5_Missense_Mutation_p.E660K	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	660						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		ACGACATTTTCTGAGCACAGG	0.433000													13	112					0	0	0.000308642	0	0
LILRA3	11026	broad.mit.edu	37	19	54802724	54802724	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr19:54802724C>T	ENST00000391745.1	-	9	1084	c.768G>A	c.(766-768)ggG>ggA	p.G256G	LILRA3_ENST00000251390.3_Silent_p.G239G|LILRA3_ENST00000391744.3_Silent_p.G175G					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCAGCTTCTCCCCAGGGGCCA	0.597000													5	28					0	0	8.12818e-05	0	0
DIAPH3	81624	broad.mit.edu	37	13	60545066	60545066	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr13:60545066G>A	ENST00000400324.4	-	16	2099	c.1879C>T	c.(1879-1881)Cta>Tta	p.L627L	DIAPH3_ENST00000400330.1_Silent_p.L627L|DIAPH3_ENST00000377908.2_Silent_p.L616L|DIAPH3_ENST00000267215.4_Silent_p.L627L|DIAPH3_ENST00000465066.1_5'UTR|DIAPH3_ENST00000400319.1_Silent_p.L557L|DIAPH3_ENST00000400320.1_Silent_p.L581L	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	627	FH1.|Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		AGGATTGGTAGAGGAGGAGAA	0.458000													5	77					0	0	0.00116845	0	0
CATSPER1	117144	broad.mit.edu	37	11	65793650	65793650	+	Silent	SNP	G	G	A			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr11:65793650G>A	ENST00000312106.5	-	1	338	c.201C>T	c.(199-201)caC>caT	p.H67H		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	67	His-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						AGGCTTGGTCGTGGAAGTCTT	0.607000													11	83					0	0	0.00136819	0	0
AKAP1	8165	broad.mit.edu	37	17	55193620	55193620	+	Silent	SNP	C	C	T			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr17:55193620C>T	ENST00000337714.3	+	7	2663	c.2430C>T	c.(2428-2430)atC>atT	p.I810I	AKAP1_ENST00000571629.1_Silent_p.I810I|AKAP1_ENST00000572557.1_Silent_p.I810I|AKAP1_ENST00000539273.1_Silent_p.I810I	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	810	Tudor.				blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					TCCGGCAAATCAGGTGAGCGG	0.582000													10	59					0	0	0.000673444	0	0
MBOAT1	154141	broad.mit.edu	37	6	20102606	20102606	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr6:20102606delT	ENST00000541730.1	-	12	1547	c.952delA	c.(952-954)tafs	p.I319fs	MBOAT1_ENST00000324607.7_Frame_Shift_Del_p.I468fs			Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain containing 1	468					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(5)	20	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			AATAGTATTATCAGGAGACTT	0.353													9	90	---	---	---	---					
MYO18B	84700	broad.mit.edu	37	22	26317359	26317360	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-BF-A1PX-01A-12D-A19A-08	TCGA-BF-A1PX-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aed7006f-6ea1-4251-b6a2-17919eae8030	c341afa8-58ab-493f-a0fd-4d44754effff	g.chr22:26317359_26317360insAA	ENST00000335473.7	+	34	5750_5751	c.5500_5501insAA	c.(5500-5502)gaafs	p.E1834fs	MYO18B_ENST00000407587.2_Frame_Shift_Ins_p.E1835fs|MYO18B_ENST00000536101.1_Frame_Shift_Ins_p.E1834fs	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1834	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GGAGGAGCTGGAGAAAGTGCAC	0.574													2	4	---	---	---	---