Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIF2B	84643	broad.mit.edu	37	17	51901912	51901912	+	Silent	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr17:51901912C>T	ENST00000268919.4	+	1	1674	c.1518C>T	c.(1516-1518)tcC>tcT	p.S506S		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	506					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TCCGGGACTCCTTTATAGGCC	0.483000													9	40					0	0	0.000442599	0	0
SNIP1	79753	broad.mit.edu	37	1	38005830	38005830	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr1:38005830C>T	ENST00000296215.6	-	3	926	c.854G>A	c.(853-855)cGa>cAa	p.R285Q		NM_024700.3	NP_078976.2	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein 1	285	FHA.				production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			breast(2)|cervix(2)|endometrium(1)|large_intestine(3)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	25		Myeloproliferative disorder(586;0.0393)				GCGGCGGTGTCGACCCAGTAG	0.468000													18	53					0	0	0.00074312	0	0
RFC2	5982	broad.mit.edu	37	7	73646517	73646517	+	Silent	SNP	C	C	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr7:73646517C>A	ENST00000055077.3	-	11	1044	c.984G>T	c.(982-984)gcG>gcT	p.A328A	RFC2_ENST00000352131.3_Silent_p.A294A	NM_181471.1	NP_852136.1	P35250	RFC2_HUMAN	replication factor C (activator 1) 2, 40kDa	328					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(3)	8						TCACTCCTTCCGCTATTTTCA	0.433000													4	48					0.000602214	0.00888513	0.000602214	1	0
ZFP42	132625	broad.mit.edu	37	4	188924150	188924150	+	Silent	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr4:188924150C>T	ENST00000326866.4	+	4	597	c.189C>T	c.(187-189)ctC>ctT	p.L63L	ZFP42_ENST00000509524.1_Silent_p.L63L	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	63					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		CTCAGGCTCTCGGAGGGGATG	0.512000													14	48					0	0	0.000308642	0	0
FAM78B	149297	broad.mit.edu	37	1	166135377	166135377	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr1:166135377T>C	ENST00000338353.3	-	2	698	c.109A>G	c.(109-111)Acc>Gcc	p.T37A	FAM78B_ENST00000354422.3_Missense_Mutation_p.T37A			Q5VT40	FA78B_HUMAN	family with sequence similarity 78, member B	37										central_nervous_system(1)|endometrium(5)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					ATGGGCGAGGTCTCCTCGATG	0.652000													5	7					0	0	0.000157383	0	0
KCNN4	3783	broad.mit.edu	37	19	44271811	44271811	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr19:44271811G>A	ENST00000262888.3	-	8	1563	c.1168C>T	c.(1168-1170)Cgg>Tgg	p.R390W		NM_002250.2	NP_002241.1	O15554	KCNN4_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	390					defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding	p.R390W(1)		biliary_tract(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)	TCCAGGGCCCGGTGTGAGCTG	0.622000													14	79					0	0	0.000308642	0	0
POLA2	23649	broad.mit.edu	37	11	65036175	65036175	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr11:65036175T>A	ENST00000265465.3	+	4	860	c.329T>A	c.(328-330)tTg>tAg	p.L110*	POLA2_ENST00000541089.1_5'UTR	NM_002689.2	NP_002680.2	Q14181	DPOA2_HUMAN	polymerase (DNA directed), alpha 2, accessory subunit	110					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding			endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	11					Dacarbazine(DB00851)	GAAATCCTCTTGAACTCTTAC	0.373000													13	16					0	0	0.00074312	0	0
NDUFA4	4697	broad.mit.edu	37	7	10977742	10977742	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr7:10977742T>A	ENST00000339600.5	-	3	362	c.164A>T	c.(163-165)aAa>aTa	p.K55I		NM_002489.3	NP_002480.1	O00483	NDUA4_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa	55					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			large_intestine(2)|lung(1)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)	NADH(DB00157)	GGGACCCAGTTTGTTCCAGGG	0.318000													13	36					0	0	0.000422831	0	0
PKP1	5317	broad.mit.edu	37	1	201286702	201286702	+	Silent	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr1:201286702C>T	ENST00000263946.3	+	5	1100	c.849C>T	c.(847-849)gtC>gtT	p.V283V	PKP1_ENST00000367324.3_Silent_p.V283V|PKP1_ENST00000475988.1_3'UTR|PKP1_ENST00000352845.3_Silent_p.V283V	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	283					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						CCTGGCAGGTCTATCAGCTGG	0.547000													9	61					0	0	0.000978159	0	0
KIAA1614	57710	broad.mit.edu	37	1	180885324	180885324	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr1:180885324G>A	ENST00000367588.4	+	2	140	c.85G>A	c.(85-87)Gtg>Atg	p.V29M		NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	29										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						AGCCAGCCCCGTGGAGGGGAC	0.607000													11	47					0	0	0.000219431	0	0
C6orf222	389384	broad.mit.edu	37	6	36288968	36288968	+	Silent	SNP	T	T	G			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr6:36288968T>G	ENST00000437635.2	-	10	1809	c.1632A>C	c.(1630-1632)gcA>gcC	p.A544A		NM_001010903.4	NP_001010903.3	P0C671	CF222_HUMAN	chromosome 6 open reading frame 222	544										breast(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(4)|urinary_tract(4)	26						CTTGGAGAAGTGCCACAAGCT	0.542000													10	1					0	0	0.000442599	0	0
C7orf31	136895	broad.mit.edu	37	7	25176283	25176283	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr7:25176283G>A	ENST00000409280.1	-	10	1389	c.1081C>T	c.(1081-1083)Cct>Tct	p.P361S	C7orf31_ENST00000283905.3_Missense_Mutation_p.P361S			Q8N865	CG031_HUMAN	chromosome 7 open reading frame 31	361										autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|skin(2)|stomach(1)	14						AAAACTCTAGGAGTACAATCT	0.453000													26	56					0	0	0.000878237	0	0
NUP210	23225	broad.mit.edu	37	3	13438970	13438970	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr3:13438970C>T	ENST00000254508.5	-	3	405	c.323G>A	c.(322-324)cGc>cAc	p.R108H		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	108					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					GGCATCACAGCGCAGGACCTG	0.622000													14	21					0	0	0.000566183	0	0
MARK1	4139	broad.mit.edu	37	1	220777410	220777410	+	Splice_Site	SNP	T	T	G			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr1:220777410T>G	ENST00000402574.1	+	6	1023	c.19_splice	c.e6-1	p.G7_splice	MARK1_ENST00000366917.4_Splice_Site_p.G142_splice|MARK1_ENST00000366918.4_Splice_Site_p.G120_splice	NM_018650.3	NP_061120.3	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	142					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		CTGATTCAGGTGAAGTATTTG	0.323000													12	96					0	0	0.000308642	0	0
ZNF711	7552	broad.mit.edu	37	X	84526576	84526576	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chrX:84526576G>T	ENST00000360700.4	+	10	3052	c.2166G>T	c.(2164-2166)ttG>ttT	p.L722F	ZNF711_ENST00000395402.1_Missense_Mutation_p.L684F|ZNF711_ENST00000276123.3_Missense_Mutation_p.L676F|ZNF711_ENST00000373165.3_Missense_Mutation_p.L676F|ZNF711_ENST00000542798.1_Missense_Mutation_p.L518F			Q9Y462	ZN711_HUMAN	zinc finger protein 711	676					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						ATCAGCCATTGAAATGTAAAA	0.373000													18	45					3.52763e-06	5.56994e-05	0.000566183	1	0
NOLC1	9221	broad.mit.edu	37	10	103917932	103917932	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr10:103917932G>A	ENST00000405356.1	+	5	803	c.568G>A	c.(568-570)Gtg>Atg	p.V190M	NOLC1_ENST00000605788.1_Missense_Mutation_p.V190M|NOLC1_ENST00000603742.1_5'UTR|NOLC1_ENST00000488254.2_Missense_Mutation_p.V191M			Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	190	11 X 12 AA approximate repeats of an acidic serine cluster.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	31		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		GATAACACCTGTGACAGTTAA	0.512000													6	27					0	0	8.12818e-05	0	0
ASMT	438	broad.mit.edu	37	X	1746653	1746653	+	Silent	SNP	G	G	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chrX:1746653G>A	ENST00000381241.3	+	4	631	c.432G>A	c.(430-432)acG>acA	p.T144T	ASMT_ENST00000381229.4_Silent_p.T144T|RP13-297E16.3_ENST00000509780.1_RNA|ASMT_ENST00000381233.3_Silent_p.T144T	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	144					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGCTTTTTACGGCCATCTACA	0.393000													11	190					0	0	0.000219431	0	0
ZNF462	58499	broad.mit.edu	37	9	109689800	109689800	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr9:109689800C>T	ENST00000277225.5	+	3	3896	c.3607C>T	c.(3607-3609)Cgg>Tgg	p.R1203W	ZNF462_ENST00000457913.1_Missense_Mutation_p.R1203W|ZNF462_ENST00000441147.2_Missense_Mutation_p.R48W			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1203					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						TTATGGGAACCGGACGGTCAA	0.527000													162	122					0	0	0.000781405	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55047086	55047086	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr19:55047086G>A	ENST00000335056.3	+	4	669	c.631G>A	c.(631-633)Gac>Aac	p.D211N	KIR3DX1_ENST00000482404.1_3'UTR																endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		GGCTCCCAGTGACCCCCTGGA	0.547000													7	60					0	0	0.000157383	0	0
KLHL40	131377	broad.mit.edu	37	3	42728091	42728091	+	Silent	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr3:42728091C>T	ENST00000287777.4	+	1	1081	c.981C>T	c.(979-981)ggC>ggT	p.G327G		NM_152393.2	NP_689606.2			kelch-like family member 40																		GTGAGGAGGGCGCTGTGGCCT	0.572000													12	29					0	0	0.000978159	0	0
EPPK1	83481	broad.mit.edu	37	8	144946344	144946344	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr8:144946344C>T	ENST00000525985.1	-	2	1149	c.1078G>A	c.(1078-1080)Gag>Aag	p.E360K				P58107	EPIPL_HUMAN	epiplakin 1	360						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACGGCCTGCTCGGCCACCAGG	0.662000													4	24					0	0	0.00024832	0	0
PHTF2	57157	broad.mit.edu	37	7	77583129	77583129	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr7:77583129C>A	ENST00000416283.2	+	17	2279	c.2153C>A	c.(2152-2154)cCg>cAg	p.P718Q	PHTF2_ENST00000248550.7_Missense_Mutation_p.P752Q|PHTF2_ENST00000307305.8_Missense_Mutation_p.P714Q|PHTF2_ENST00000422959.2_Missense_Mutation_p.P718Q|PHTF2_ENST00000275575.7_Missense_Mutation_p.P662Q	NM_001127357.1|NM_020432.4	NP_001120829.1|NP_065165.3	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	752					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	19						ACAATGAATCCGCTGCTTTAT	0.373000													4	48					0.000602214	0.00888513	0.000602214	1	0
PCDHB12	56124	broad.mit.edu	37	5	140590562	140590562	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr5:140590562G>C	ENST00000239450.2	+	1	2272	c.2083G>C	c.(2083-2085)Gcc>Ccc	p.A695P	PCDHB12_ENST00000541609.1_Missense_Mutation_p.A358P	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		695					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGGCGTTGGCCTCAGTGTC	0.711000													22	76					0	0	0.000295444	0	0
PCF11	51585	broad.mit.edu	37	11	82879917	82879917	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr11:82879917G>A	ENST00000298281.4	+	8	2992	c.2540G>A	c.(2539-2541)cGg>cAg	p.R847Q		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	847	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						GGTGGTTTTCGGTTTGAAGGT	0.567000													16	28					0	0	0.000422831	0	0
DLGAP2	9228	broad.mit.edu	37	8	1624758	1624758	+	Silent	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr8:1624758C>T	ENST00000421627.2	+	8	2156	c.2022C>T	c.(2020-2022)gtC>gtT	p.V674V		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	753					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ACCACTCTGTCGGGGTGCAAG	0.542000													6	2					0	0	0.00116845	0	0
SSBP2	23635	broad.mit.edu	37	5	80762838	80762838	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr5:80762838G>T	ENST00000320672.4	-	9	803	c.593C>A	c.(592-594)cCc>cAc	p.P198H	SSBP2_ENST00000509053.1_Missense_Mutation_p.P168H|SSBP2_ENST00000505980.1_Missense_Mutation_p.P178H|SSBP2_ENST00000514493.1_Missense_Mutation_p.P168H|SSBP2_ENST00000515395.1_Missense_Mutation_p.P176H	NM_001256732.1|NM_001256733.1|NM_012446.3	NP_001243661.1|NP_001243662.1|NP_036578.2	P81877	SSBP2_HUMAN	single-stranded DNA binding protein 2	198	Gly-rich.|Pro-rich.				regulation of transcription, DNA-dependent	cytoplasm|nucleus	single-stranded DNA binding		SSBP2/JAK2(4)	central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10		Lung NSC(167;0.00154)|all_lung(232;0.00179)|Ovarian(174;0.0338)		OV - Ovarian serous cystadenocarcinoma(54;1.07e-41)|Epithelial(54;2.79e-35)|all cancers(79;1.18e-29)		ATTCAGTGGGGGTCTCATTGC	0.393000													13	27					1.15088e-07	1.84962e-06	0.000422831	1	0
RNF148	378925	broad.mit.edu	37	7	122342619	122342619	+	Silent	SNP	G	G	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr7:122342619G>A	ENST00000434824.1	-	1	402	c.186C>T	c.(184-186)ttC>ttT	p.F62F	CADPS2_ENST00000313070.7_Intron|CADPS2_ENST00000412584.2_Intron|CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000449022.2_Intron|RNF148_ENST00000447240.1_Intron	NM_198085.1	NP_932351.1	Q8N7C7	RN148_HUMAN	ring finger protein 148	62						integral to membrane	zinc ion binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(7)	16						AATGATTCCCGAACACTCCAC	0.468000													13	24					0	0	0.000219431	0	0
PKDREJ	10343	broad.mit.edu	37	22	46654923	46654923	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr22:46654923T>C	ENST00000253255.5	-	1	4296	c.4297A>G	c.(4297-4299)Agt>Ggt	p.S1433G		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1433					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ATTAAGACACTTTCAATTCCT	0.343000													11	66					0	0	0.000978159	0	0
CTSG	1511	broad.mit.edu	37	14	25043625	25043625	+	Silent	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr14:25043625C>T	ENST00000216336.2	-	4	456	c.420G>A	c.(418-420)acG>acA	p.T140T		NM_001911.2	NP_001902.1	P08311	CATG_HUMAN	cathepsin G	140	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity	p.T140T(1)		autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(265;0.0269)		CAGTGCACAGCGTCCCGGGTC	0.612000													14	34					0	0	0.000422831	0	0
LILRB4	11006	broad.mit.edu	37	19	55176302	55176302	+	Splice_Site	SNP	T	T	G			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr19:55176302T>G	ENST00000391736.1	+	7	1021		c.e7+2		LILRB4_ENST00000391734.3_Splice_Site|LILRB4_ENST00000430952.2_Splice_Site|LILRB4_ENST00000391733.3_Splice_Site|LILRB4_ENST00000270452.2_Splice_Site	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4							integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		CAACAGCTGGTGAGTCTCAGA	0.572000													12	9					0	0	0.000978159	0	0
IMPG2	50939	broad.mit.edu	37	3	101022994	101022994	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr3:101022994A>T	ENST00000193391.7	-	3	684	c.497T>A	c.(496-498)aTg>aAg	p.M166K		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	166					visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						ACTTACCTTCATGATTAAGCT	0.393000													17	40					0	0	0.00074312	0	0
GLRB	2743	broad.mit.edu	37	4	158059985	158059985	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr4:158059985G>A	ENST00000264428.4	+	7	905	c.635G>A	c.(634-636)cGa>cAa	p.R212Q	GLRB_ENST00000541722.1_Missense_Mutation_p.R212Q|GLRB_ENST00000509282.1_Missense_Mutation_p.R212Q|GLRB_ENST00000512619.1_Intron	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	212					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	GATGATTTACGATTTATCTGG	0.259000													13	71					0	0	0.000308642	0	0
TP63	8626	broad.mit.edu	37	3	189349361	189349361	+	Silent	SNP	C	C	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr3:189349361C>A	ENST00000264731.3	+	1	146	c.57C>A	c.(55-57)atC>atA	p.I19I	TP63_ENST00000418709.2_Silent_p.I19I|TP63_ENST00000382063.4_Silent_p.I19I|TP63_ENST00000440651.2_Silent_p.I19I|TP63_ENST00000320472.5_Silent_p.I19I|TP63_ENST00000392460.3_Silent_p.I19I	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	19	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ACCCTTACATCCAGCGGTGAG	0.398000										HNSCC(45;0.13)			15	20					5.01169e-05	0.000764496	0.000566183	1	0
COL4A2	1284	broad.mit.edu	37	13	111137367	111137367	+	Silent	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr13:111137367C>T	ENST00000360467.5	+	33	3324	c.3018C>T	c.(3016-3018)ggC>ggT	p.G1006G		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1006	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GATACCTGGGCGCAAAAGGTG	0.627000													3	8					0	0	6.4e-05	0	0
C1orf173	127254	broad.mit.edu	37	1	75055422	75055422	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr1:75055422T>G	ENST00000326665.5	-	12	2287	c.2069A>C	c.(2068-2070)aAa>aCa	p.K690T	RP4-612J11.1_ENST00000416017.1_RNA|C1orf173_ENST00000420661.2_Missense_Mutation_p.K493T	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	690	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AGAAACATGTTTCCCGGACTT	0.453000													66	72					0	0	0.000781405	0	0
TMC3	342125	broad.mit.edu	37	15	81625347	81625347	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr15:81625347C>G	ENST00000558726.1	-	22	2854	c.2719G>C	c.(2719-2721)Gaa>Caa	p.E907Q	TMC3_ENST00000359440.5_Missense_Mutation_p.E906Q|RP11-761I4.3_ENST00000559781.1_RNA|RP11-761I4.3_ENST00000560851.1_RNA|RP11-761I4.3_ENST00000560973.1_RNA			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	906						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						AAATGTCTTTCTGGCCAGACA	0.522000													17	44					0	0	0.000958276	0	0
RSBN1L	222194	broad.mit.edu	37	7	77325804	77325804	+	Silent	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr7:77325804C>T	ENST00000334955.7	+	1	45	c.18C>T	c.(16-18)agC>agT	p.S6S		NM_198467.2	NP_940869.2	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like	6						nucleus				central_nervous_system(1)|endometrium(12)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AACCGCCGAGCCCCGTGCACT	0.692000													45	9					0	0	0.000781405	0	0
AHNAK2	113146	broad.mit.edu	37	14	105408731	105408731	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr14:105408731C>T	ENST00000333244.5	-	7	13176	c.13057G>A	c.(13057-13059)Gct>Act	p.A4353T	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4353						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCCAGATCAGCGGAAGGGGGC	0.622000													29	68					0	0	0.00106085	0	0
ZBTB26	57684	broad.mit.edu	37	9	125681625	125681625	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr9:125681625T>C	ENST00000373656.3	-	2	662	c.589A>G	c.(589-591)Aaa>Gaa	p.K197E	ZBTB26_ENST00000373654.1_Missense_Mutation_p.K197E	NM_020924.2	NP_065975.1	Q9HCK0	ZBT26_HUMAN	zinc finger and BTB domain containing 26	197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)	11						TGATCTTTTTTACTTCTAACC	0.388000													12	39					0	0	0.000151284	0	0
WASH6P	653440	broad.mit.edu	37	X	155255094	155255094	+	RNA	SNP	T	T	C			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chrX:155255094T>C	ENST00000285718.7	+	0	1399				WASH6P_ENST00000461007.1_RNA																							TGCTCTGACATGGACACAGCC	0.617000													3	6					0	0	6.4e-05	0	0
PIK3R4	30849	broad.mit.edu	37	3	130405181	130405181	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr3:130405181C>T	ENST00000356763.3	-	15	3906	c.3349G>A	c.(3349-3351)Gtg>Atg	p.V1117M	PIK3R4_ENST00000512677.1_5'UTR	NM_014602.2	NP_055417.1	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	1117					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(6)|large_intestine(16)|lung(28)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	77						GAGCCATTCACAGTGGCATAG	0.463000													14	41					0	0	0.000151284	0	0
CPEB1	64506	broad.mit.edu	37	15	83226697	83226697	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr15:83226697C>T	ENST00000563800.1	-	4	2225	c.500G>A	c.(499-501)gGa>gAa	p.G167E	CPEB1_ENST00000564522.1_Missense_Mutation_p.G65E|CPEB1_ENST00000562019.1_Missense_Mutation_p.G140E|CPEB1_ENST00000450751.2_Missense_Mutation_p.G65E|CPEB1_ENST00000423133.2_Missense_Mutation_p.G65E|CPEB1_ENST00000398591.2_Missense_Mutation_p.G65E|CPEB1_ENST00000398592.2_Intron|CPEB1_ENST00000261723.6_Missense_Mutation_p.G143E|CPEB1_ENST00000568757.1_Missense_Mutation_p.G65E|RP11-379H8.1_ENST00000568285.1_Intron|CPEB1_ENST00000568128.1_Missense_Mutation_p.G140E			Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding protein 1	140					mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding	p.G65E(1)		breast(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(1)|skin(1)	28			BRCA - Breast invasive adenocarcinoma(143;0.229)			GGGGGGTTTTCCTAGGACATT	0.522000													17	31					0	0	0.00121646	0	0
SERPINI2	5276	broad.mit.edu	37	3	167183148	167183148	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr3:167183148C>T	ENST00000476257.1	-	6	1010	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K	SERPINI2_ENST00000461846.1_Missense_Mutation_p.E238K|SERPINI2_ENST00000471111.1_Missense_Mutation_p.E238K|SERPINI2_ENST00000264677.4_Missense_Mutation_p.E238K			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	238					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						TAAGACAATTCTAAAACTTGG	0.313000													5	71					0	0	0.000602214	0	0
SNX33	257364	broad.mit.edu	37	15	75942635	75942635	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr15:75942635G>C	ENST00000308527.5	+	1	2389	c.1192G>C	c.(1192-1194)Gtg>Ctg	p.V398L		NM_153271.1	NP_695003.1	Q8WV41	SNX33_HUMAN	sorting nexin 33	398	BAR.				cell communication		phosphatidylinositol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|soft_tissue(1)|urinary_tract(2)	19						GCTCAGCACTGTGGCATCAGA	0.572000													7	23					0	0	0.000157383	0	0
CSMD1	64478	broad.mit.edu	37	8	3081268	3081268	+	Silent	SNP	G	G	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr8:3081268G>A	ENST00000602557.1	-	29	5025	c.4470C>T	c.(4468-4470)atC>atT	p.I1490I	CSMD1_ENST00000602723.1_Silent_p.I1490I|CSMD1_ENST00000542608.1_Silent_p.I1489I|CSMD1_ENST00000539096.1_Silent_p.I1489I|CSMD1_ENST00000400186.3_Silent_p.I1490I|CSMD1_ENST00000537824.1_Silent_p.I1489I|CSMD1_ENST00000520002.1_Silent_p.I1490I|CSMD1_ENST00000523387.1_5'UTR			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1490	CUB 9.					integral to membrane		p.I1489I(1)|p.I1218I(1)		breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ATATCAAGGCGATGACAAAGT	0.428000													21	62					0	0	0.000720815	0	0
RAC1	5879	broad.mit.edu	37	7	6439807	6439807	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr7:6439807T>G	ENST00000348035.4	+	4	489	c.276T>G	c.(274-276)aaT>aaG	p.N92K	RAC1_ENST00000488373.1_3'UTR|RAC1_ENST00000356142.4_Missense_Mutation_p.N111K	NM_006908.4	NP_008839.2	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	92					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			cervix(1)|endometrium(1)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	8		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	CATTTGAAAATGTCCGTGCAA	0.338000													23	55					0	0	0.00127121	0	0
PAPPA2	60676	broad.mit.edu	37	1	176709190	176709190	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr1:176709190C>A	ENST00000367662.3	+	14	5173	c.4009C>A	c.(4009-4011)Cat>Aat	p.H1337N		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1337					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CCTTTTCCACCATACCACCTC	0.488000													24	126					3.6726e-16	6.00971e-15	0.000586117	1	0
ITGB1	3688	broad.mit.edu	37	10	33196037	33196037	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr10:33196037T>C	ENST00000423113.1	-	15	2365	c.2366A>G	c.(2365-2367)aAt>aGt	p.N789S	ITGB1_ENST00000396033.2_Intron|ITGB1_ENST00000302278.3_Intron|ITGB1_ENST00000374956.4_Intron	NM_033668.2	NP_391988.1	P05556	ITB1_HUMAN	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	789					axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Ovarian(717;1.34e-05)|Breast(68;0.0634)				ATTCTTGAAATTATTAATAGG	0.308000													51	60					0	0	0.000781405	0	0
ZNF629	23361	broad.mit.edu	37	16	30794344	30794344	+	Silent	SNP	G	G	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr16:30794344G>A	ENST00000262525.4	-	3	1512	c.1305C>T	c.(1303-1305)tgC>tgT	p.C435C		NM_001080417.1	NP_001073886.1	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(3)|urinary_tract(1)	22			Colorectal(24;0.198)			AGCTCTTGCCGCAGTCGGCGC	0.612000													29	36					0	0	0.00127121	0	0
SMAD6	4091	broad.mit.edu	37	15	67073772	67073772	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr15:67073772G>A	ENST00000288840.5	+	4	2421	c.1390G>A	c.(1390-1392)Gtc>Atc	p.V464I	SMAD6_ENST00000338426.4_Missense_Mutation_p.V203I	NM_005585.4	NP_005576.3	O43541	SMAD6_HUMAN	SMAD family member 6	464	MH2.				BMP signaling pathway|immune response|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of caspase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of SMAD protein complex assembly|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of S phase of mitotic cell cycle|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	cytosol|transcription factor complex	co-SMAD binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I activin receptor binding|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			lung(1)|skin(1)	2						CCCCAACAGCGTCCGCATCAG	0.682000													13	19					0	0	0.000219431	0	0
SMARCA2	6595	broad.mit.edu	37	9	2161877	2161877	+	Silent	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr9:2161877C>T	ENST00000382203.1	+	28	4382	c.4173C>T	c.(4171-4173)atC>atT	p.I1391I	SMARCA2_ENST00000382186.1_Silent_p.I55I|SMARCA2_ENST00000324954.5_Silent_p.I55I|SMARCA2_ENST00000302401.3_Silent_p.I97I|SMARCA2_ENST00000382194.1_Silent_p.I1391I|SMARCA2_ENST00000357248.2_Silent_p.I1391I|SMARCA2_ENST00000382185.1_Silent_p.I55I|SMARCA2_ENST00000349721.2_Silent_p.I1391I			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1391					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ACGCTATCATCGATACTGTGA	0.488000													9	17					0	0	0.000274275	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													4	51					0	0	0.00116845	0	0
RQCD1	9125	broad.mit.edu	37	2	219447748	219447748	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr2:219447748T>C	ENST00000273064.6	+	3	634	c.259T>C	c.(259-261)Tct>Cct	p.S87P	RQCD1_ENST00000295701.5_Missense_Mutation_p.S87P|RQCD1_ENST00000542068.1_Missense_Mutation_p.S87P|RQCD1_ENST00000509807.2_Missense_Mutation_p.S87P	NM_005444.2	NP_005435.1	Q92600	RCD1_HUMAN	RCD1 required for cell differentiation1 homolog (S. pombe)	87					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|sex differentiation|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|prostate(3)|skin(1)	15		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000192)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCACACCAGTCTAACAGAGT	0.388000													17	41					0	0	0.000375601	0	0
WNK2	65268	broad.mit.edu	37	9	95993181	95993181	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr9:95993181G>T	ENST00000297954.4	+	3	866	c.866G>T	c.(865-867)cGg>cTg	p.R289L	WNK2_ENST00000427277.2_5'UTR|WNK2_ENST00000395475.2_Missense_Mutation_p.R275L|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000395477.2_Missense_Mutation_p.R289L|WNK2_ENST00000349097.3_5'UTR			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	289	Protein kinase.				intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						TACCTGAAGCGGTTCAAGGTG	0.622000													20	5					1.15919e-05	0.000179874	0.00121646	1	0
PITPNM2	57605	broad.mit.edu	37	12	123482052	123482052	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr12:123482052C>T	ENST00000280562.5	-	10	1497	c.1292G>A	c.(1291-1293)gGa>gAa	p.G431E	PITPNM2_ENST00000542749.1_Missense_Mutation_p.G431E|PITPNM2_ENST00000392428.1_Missense_Mutation_p.G152E|PITPNM2_ENST00000320201.4_Missense_Mutation_p.G431E			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	431					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		GATGGTGCCTCCGTGCAGCAC	0.642000													25	46					0	0	0.000720815	0	0
PNN	5411	broad.mit.edu	37	14	39648305	39648305	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr14:39648305G>A	ENST00000216832.4	+	7	576	c.509G>A	c.(508-510)cGc>cAc	p.R170H	PNN_ENST00000557680.1_3'UTR|PNN_ENST00000553331.1_3'UTR	NM_002687.3	NP_002678.2	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	170	Necessary for interaction with RNPS1.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)|stomach(1)	27	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		CAAAAGCGGCGCCAGGAAATT	0.358000													12	27					0	0	0.000151284	0	0
SNHG12	85028	broad.mit.edu	37	1	28906819	28906820	+	RNA	INS	-	-	A	rs147786269		TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr1:28906819_28906820insA	ENST00000488745.1	-	0	1100				SNHG12_ENST00000475441.1_RNA|SNHG12_ENST00000531126.1_RNA|SNHG12_ENST00000483436.1_RNA																							gactccgtctcaaaaaaaaaaa	0.490													3	4	---	---	---	---					
NPHP3	27031	broad.mit.edu	37	3	132440872	132440873	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr3:132440872_132440873delAC	ENST00000326682.8	-	1	403_404	c.327_328delGT	c.(325-330)tttgfs	p.LL109fs	NPHP3_ENST00000383282.2_Frame_Shift_Del_p.LL109fs|NPHP3-AS1_ENST00000489343.1_RNA|NPHP3_ENST00000343113.4_Frame_Shift_Del_p.LL109fs|NPHP3_ENST00000337331.5_Frame_Shift_Del_p.LL109fs			Q7Z494	NPHP3_HUMAN	nephronophthisis 3 (adolescent)	109					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(15)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CCCATGGACAACAACTCCTGGT	0.673													13	36	---	---	---	---					
NOL8	55035	broad.mit.edu	37	9	95072931	95072932	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr9:95072931_95072932insT	ENST00000545558.1	-	9	2990_2991	c.2498_2499insA	c.(2497-2499)actfs	p.T833fs	NOL8_ENST00000442668.2_Frame_Shift_Ins_p.T833fs|NOL8_ENST00000542053.1_Frame_Shift_Ins_p.T765fs|NOL8_ENST00000358855.4_Frame_Shift_Ins_p.T765fs|NOL8_ENST00000535387.1_Frame_Shift_Ins_p.T795fs			Q76FK4	NOL8_HUMAN	nucleolar protein 8	833					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						TATCAAACAGCTTCCCTGATGT	0.396													27	61	---	---	---	---					
SIPA1	6494	broad.mit.edu	37	11	65414446	65414446	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr11:65414446delG	ENST00000394224.3	+	8	2237	c.1941delG	c.(1939-1941)ctfs	p.L647fs	SIPA1_ENST00000534313.1_Frame_Shift_Del_p.L647fs|SIPA1_ENST00000394227.3_Frame_Shift_Del_p.L545fs|SIPA1_ENST00000527525.1_Frame_Shift_Del_p.L545fs	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	647					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						AGCAGCAGCTGGACCTGTACC	0.721													2	4	---	---	---	---					
MYO19	80179	broad.mit.edu	37	17	34883406	34883407	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr17:34883406_34883407delCT	ENST00000431794.3	-	5	797_798	c.275_276delAG	c.(274-276)gfs	p.E92fs	MYO19_ENST00000544606.1_Intron|MYO19_ENST00000268852.9_Frame_Shift_Del_p.E92fs|MYO19_ENST00000586007.1_Frame_Shift_Del_p.E92fs	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	92	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CAGCATGGTACTCTCTCATTAG	0.579													15	20	---	---	---	---					
RP11-53I6.2	0	broad.mit.edu	37	18	29656288	29656288	+	RNA	DEL	T	T	-			TCGA-FS-A1ZU-06A-12D-A196-08	TCGA-FS-A1ZU-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe8c62a6-c113-46e8-ab91-fdb90bb6a59f	7a49b1e5-5fb7-4a7e-85ba-f4c357089023	g.chr18:29656288delT	ENST00000583184.1	+	0	539																											tgtttttttgttttttttttg	0.438													2	4	---	---	---	---