Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NDUFS3	4722	broad.mit.edu	37	11	47603718	47603718	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr11:47603718G>C	ENST00000263774.4	+	5	542	c.460G>C	c.(460-462)Gag>Cag	p.E154Q	NDUFS3_ENST00000533507.1_3'UTR	NM_004551.2	NP_004542.1	O75489	NDUS3_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	154					induction of apoptosis|mitochondrial electron transport, NADH to ubiquinone|negative regulation of cell growth|reactive oxygen species metabolic process|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)	9					NADH(DB00157)	GACGCCCATTGAGTCTGCTGT	0.522000													6	75					0	0	1	0	0
SLC7A14	57709	broad.mit.edu	37	3	170216549	170216549	+	Silent	SNP	C	C	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr3:170216549C>T	ENST00000231706.4	-	4	981	c.666G>A	c.(664-666)ctG>ctA	p.L222L	CLDN11_ENST00000486975.1_Intron|CLDN11_ENST00000451576.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14	222						integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			CCCATACTGCCAGGTTCAGCA	0.517000													3	42					0	0	1	0	0
EWSR1	2130	broad.mit.edu	37	22	29688155	29688155	+	Silent	SNP	C	C	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr22:29688155C>T	ENST00000397938.2	+	10	1361	c.1042C>T	c.(1042-1044)Cta>Tta	p.L348L	EWSR1_ENST00000331029.7_Intron|EWSR1_ENST00000414183.2_Silent_p.L353L|EWSR1_ENST00000332035.6_Silent_p.L292L|EWSR1_ENST00000332050.6_Silent_p.L275L|EWSR1_ENST00000406548.1_Silent_p.L347L	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	348		Breakpoint for insertion to form EWSR1- FEV fusion protein.			regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						AGATCTTGATCTAGGTAATTT	0.388000			T	"""FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"""	"""Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"""								25	34					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43603548	43603548	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr22:43603548T>A	ENST00000360835.3	-	21	2932	c.2806A>T	c.(2806-2808)Att>Ttt	p.I936F		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	936					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				ACTTTCAAAATTTCCTGGTGG	0.607000													11	184					0	0	1	0	0
MICALL1	85377	broad.mit.edu	37	22	38329058	38329058	+	Silent	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr22:38329058G>A	ENST00000215957.6	+	13	2373	c.2247G>A	c.(2245-2247)caG>caA	p.Q749Q	MICALL1_ENST00000402631.1_3'UTR	NM_033386.3	NP_203744.1	Q8N3F8	MILK1_HUMAN	MICAL-like 1	749						cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	24	Melanoma(58;0.045)					TCAAGCAGCAGAACCTGGAGC	0.602000													54	90					0	0	1	0	0
ZFP14	57677	broad.mit.edu	37	19	36832163	36832163	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr19:36832163G>A	ENST00000270001.7	-	5	680	c.565C>T	c.(565-567)Caa>Taa	p.Q189*		NM_020917.2	NP_065968.1	Q9HCL3	ZFP14_HUMAN	ZFP14 zinc finger protein	189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	26	Esophageal squamous(110;0.162)					CTCAGGTGTTGACTAAGTGTT	0.408000													12	92					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152623200	152623200	+	Splice_Site	SNP	T	T	C			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr6:152623200T>C	ENST00000367255.5	-	92	17948		c.e92-2		SYNE1_ENST00000265368.4_Splice_Site|SYNE1_ENST00000356820.4_Splice_Site|SYNE1_ENST00000341594.5_Splice_Site|SYNE1_ENST00000448038.1_Splice_Site|SYNE1_ENST00000423061.1_Splice_Site	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1						cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CGCCAGCTCCTGAGGAAACAT	0.532000										HNSCC(10;0.0054)			23	32					0	0	1	0	0
POF1B	79983	broad.mit.edu	37	X	84634218	84634218	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chrX:84634218G>A	ENST00000262753.4	-	2	387	c.242C>T	c.(241-243)aCc>aTc	p.T81I	POF1B_ENST00000373145.3_Missense_Mutation_p.T81I	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	81							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						GTAGGAGGAGGTGGTTTTGAG	0.507000													5	10					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87810828	87810828	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr7:87810828G>A	ENST00000398204.4	+	27	2632	c.2309G>A	c.(2308-2310)gGg>gAg	p.G770E	ADAM22_ENST00000398209.3_Missense_Mutation_p.G770E|ADAM22_ENST00000265727.7_Missense_Mutation_p.G806E|ADAM22_ENST00000315984.7_Missense_Mutation_p.G770E|ADAM22_ENST00000398201.4_Missense_Mutation_p.G806E	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	806					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			AGGTCAAATGGGCTCTCTCAT	0.368000													17	21					0	0	1	0	0
APOL5	80831	broad.mit.edu	37	22	36124892	36124892	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr22:36124892C>G	ENST00000249044.2	+	4	1249	c.1249C>G	c.(1249-1251)Cca>Gca	p.P417A		NM_030642.1	NP_085145.1	Q9BWW9	APOL5_HUMAN	apolipoprotein L, 5	417					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|skin(2)|urinary_tract(1)	19						CCAGCCAGCCCCACCAGCACC	0.627000													4	62					0	0	1	0	0
PRPF6	24148	broad.mit.edu	37	20	62663321	62663321	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr20:62663321G>A	ENST00000535781.1	+	19	2588	c.2477G>A	c.(2476-2478)cGc>cAc	p.R826H	ZNF512B_ENST00000450537.1_Intron|ZNF512B_ENST00000217130.3_Intron			O94906	PRP6_HUMAN	pre-mRNA processing factor 6	866					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					TGGTTCCACCGCACTGTGAAG	0.592000													4	109					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110827615	110827615	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr13:110827615C>A	ENST00000375820.4	-	37	3269	c.3148G>T	c.(3148-3150)Ggg>Tgg	p.G1050W		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1050	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCTGCCTGCCCTTTCTCTCCT	0.572000													5	30					8.12818e-05	8.40372e-05	1	1	0
HCRTR2	3062	broad.mit.edu	37	6	55147214	55147214	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr6:55147214C>A	ENST00000370862.3	+	7	1633	c.1297C>A	c.(1297-1299)Cca>Aca	p.P433T		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	433					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AAGCACACTCCCAGCAGCCAA	0.408000													3	23					2.56e-06	2.69241e-06	1	1	0
MICALL1	85377	broad.mit.edu	37	22	38328830	38328830	+	Silent	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr22:38328830G>A	ENST00000215957.6	+	12	2295	c.2169G>A	c.(2167-2169)gtG>gtA	p.V723V	MICALL1_ENST00000402631.1_3'UTR	NM_033386.3	NP_203744.1	Q8N3F8	MILK1_HUMAN	MICAL-like 1	723						cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	24	Melanoma(58;0.045)					ACATGCTGGTGGACTGGTTCA	0.622000													30	70					0	0	1	0	0
OR4C13	283092	broad.mit.edu	37	11	49974838	49974838	+	Silent	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr11:49974838G>A	ENST00000555099.1	+	1	896	c.864G>A	c.(862-864)agG>agA	p.R288R		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	288					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						ACACCTTGAGGAATGCTCAAA	0.383000													24	54					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118284445	118284445	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chrX:118284445C>T	ENST00000402510.2	-	1	97	c.98G>A	c.(97-99)cGa>cAa	p.R33Q		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	33										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						CCTGGCCCCTCGGTCCCTGGG	0.602000													26	10					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48388513	48388513	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr10:48388513A>T	ENST00000224600.4	-	1	2478	c.2365T>A	c.(2365-2367)Tac>Aac	p.Y789N		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	789	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GCCGTGGAGTAGCTGCCAGGG	0.617000													13	4					0	0	1	0	0
SYN2	6854	broad.mit.edu	37	3	12224814	12224814	+	RNA	SNP	C	C	G			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr3:12224814C>G	ENST00000432424.2	+	0	1483							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						TCTTCCAGAGCGGAACACTTA	0.488000													4	9					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86416245	86416245	+	Silent	SNP	C	C	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr7:86416245C>T	ENST00000361669.2	+	3	2236	c.1137C>T	c.(1135-1137)atC>atT	p.I379I	GRM3_ENST00000394720.2_Silent_p.I377I|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000439827.1_Silent_p.I379I|GRM3_ENST00000536043.1_Silent_p.I251I	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	379					synaptic transmission	integral to plasma membrane		p.I379M(1)		NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	ACCTGGCCATCGACAGCAGCA	0.567000													29	7					0	0	1	0	0
MICALL1	85377	broad.mit.edu	37	22	38328629	38328629	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr22:38328629G>A	ENST00000215957.6	+	11	2212	c.2086G>A	c.(2086-2088)Gat>Aat	p.D696N	MICALL1_ENST00000402631.1_3'UTR	NM_033386.3	NP_203744.1	Q8N3F8	MILK1_HUMAN	MICAL-like 1	696						cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	24	Melanoma(58;0.045)					GCGCCGGCTGGATGCCCTGGA	0.672000													13	65					0	0	1	0	0
CYP20A1	57404	broad.mit.edu	37	2	204154579	204154579	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr2:204154579C>T	ENST00000356079.4	+	10	1186	c.1063C>T	c.(1063-1065)Cga>Tga	p.R355*	CYP20A1_ENST00000461371.1_3'UTR|CYP20A1_ENST00000429815.2_Nonsense_Mutation_p.R363*	NM_177538.2	NP_803882.1	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A, polypeptide 1	355						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			cervix(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	11						AAAAATTGACCGATTTATTAT	0.333000													13	26					0	0	1	0	0
SULT4A1	25830	broad.mit.edu	37	22	44221895	44221895	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr22:44221895C>T	ENST00000330884.4	-	7	961	c.841G>A	c.(841-843)Gac>Aac	p.D281N	SULT4A1_ENST00000540422.1_Missense_Mutation_p.D168N	NM_014351.3	NP_055166.1	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	281					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity			kidney(1)|large_intestine(3)|lung(4)|ovary(1)	9		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		AAATAAAAGTCAAACGTGAGG	0.413000													139	271					0	0	1	0	0
OMG	4974	broad.mit.edu	37	17	29622049	29622049	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr17:29622049A>G	ENST00000247271.4	-	2	1562	c.1301T>C	c.(1300-1302)gTt>gCt	p.V434A	NF1_ENST00000356175.3_Intron|NF1_ENST00000358273.4_Intron	NM_002544.4	NP_002535.3	P23515	OMGP_HUMAN	oligodendrocyte myelin glycoprotein	434					cell adhesion|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	anchored to membrane|plasma membrane		p.0?(8)|p.?(3)		breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)|stomach(1)	13		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;1.81e-13)|Epithelial(4;4.04e-12)|OV - Ovarian serous cystadenocarcinoma(4;9.49e-12)|GBM - Glioblastoma multiforme(4;0.121)		CATGACCACAACATTGAGCAA	0.408000													7	41					0	0	1	0	0
RFX6	222546	broad.mit.edu	37	6	117246759	117246759	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr6:117246759G>T	ENST00000332958.2	+	16	1838	c.1822G>T	c.(1822-1824)Gga>Tga	p.G608*		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	608					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						CAGTCAACCTGGAGGCCTAGG	0.547000													7	26					0.0293803	0.0293803	1	1	0
MICALL1	85377	broad.mit.edu	37	22	38328584	38328584	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr22:38328584G>A	ENST00000215957.6	+	11	2167	c.2041G>A	c.(2041-2043)Gag>Aag	p.E681K	MICALL1_ENST00000402631.1_3'UTR	NM_033386.3	NP_203744.1	Q8N3F8	MILK1_HUMAN	MICAL-like 1	681						cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	24	Melanoma(58;0.045)					GTACATCCCTGAGGAGGACAT	0.632000													29	93					0	0	1	0	0
CNRIP1	25927	broad.mit.edu	37	2	68544407	68544407	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr2:68544407A>C	ENST00000263655.3	-	2	817	c.212T>G	c.(211-213)cTg>cGg	p.L71R	CNRIP1_ENST00000409559.3_Missense_Mutation_p.L71R|CNRIP1_ENST00000481714.1_5'UTR|CNRIP1_ENST00000409862.1_Missense_Mutation_p.L71R	NM_015463.2	NP_056278.1	Q96F85	CNRP1_HUMAN	cannabinoid receptor interacting protein 1	71							protein binding			kidney(1)|large_intestine(5)|liver(1)|lung(1)|skin(1)	9						CTTCAGTTCCAGTGGGACAAG	0.483000													9	40					0	0	1	0	0
MDFIC	29969	broad.mit.edu	37	7	114619817	114619817	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr7:114619817G>C	ENST00000393486.1	+	4	1064	c.474G>C	c.(472-474)aaG>aaC	p.K158N	MDFIC_ENST00000257724.3_Missense_Mutation_p.K267N	NM_001166345.1|NM_199072.4	NP_001159817.1|NP_951038.1	Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing	158					activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|nucleolus|nucleus	cyclin binding|Tat protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	8						TTTCCCAAAAGACAGGCTCTT	0.328000													13	56					0	0	1	0	0
CDKL5	6792	broad.mit.edu	37	X	18627601	18627601	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chrX:18627601A>G	ENST00000379989.3	+	15	2348	c.2063A>G	c.(2062-2064)gAc>gGc	p.D688G	CDKL5_ENST00000463994.1_3'UTR|CDKL5_ENST00000379996.3_Missense_Mutation_p.D688G	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	688					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					GTGTATCATGACCCACACTCT	0.438000													32	3					0	0	1	0	0
PLA2G7	7941	broad.mit.edu	37	6	46679259	46679259	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr6:46679259C>A	ENST00000274793.7	-	7	833	c.637G>T	c.(637-639)Gag>Tag	p.E213*	PLA2G7_ENST00000537365.1_Nonsense_Mutation_p.E213*|PLA2G7_ENST00000541026.1_Nonsense_Mutation_p.E86*|PLA2G7_ENST00000538237.1_Nonsense_Mutation_p.E168*	NM_005084.3	NP_005075.3	Q13093	PAFA_HUMAN	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	213					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|skin(1)|soft_tissue(1)	14			Lung(136;0.192)			TGTGTCTCCTCCTCTTGTTTC	0.408000													24	53					3.5997e-14	3.99239e-14	1	1	0
GRAMD4	23151	broad.mit.edu	37	22	47022726	47022726	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr22:47022726C>G	ENST00000406902.1	+	2	243	c.30C>G	c.(28-30)ttC>ttG	p.F10L	GRAMD4_ENST00000361034.3_Missense_Mutation_p.F10L			Q6IC98	GRAM4_HUMAN	GRAM domain containing 4	10					apoptosis	integral to membrane|mitochondrial membrane				breast(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	12		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		AAATCAGGTTCAGAGGTCACA	0.552000													46	206					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32740400	32740400	+	Silent	SNP	G	G	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr1:32740400G>T	ENST00000333070.4	+	3	268	c.168G>T	c.(166-168)ccG>ccT	p.P56P	LCK_ENST00000336890.5_Silent_p.P56P|LCK_ENST00000373564.3_Silent_p.P56P	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	56	Interactions with CD4 and CD8 (By similarity).				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	GCTCCAATCCGCCGGCTTCCC	0.617000			T	TRB@	T-ALL								11	16					6.42651e-13	7.00031e-13	1	1	0
GANC	2595	broad.mit.edu	37	15	42632949	42632949	+	Silent	SNP	C	C	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr15:42632949C>T	ENST00000318010.8	+	18	2389	c.2149C>T	c.(2149-2151)Ctg>Ttg	p.L717L		NM_198141.2	NP_937784.2	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	717					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		TGAATACATGCTGGGTGAGCA	0.403000													18	26					0	0	1	0	0
GPR20	2843	broad.mit.edu	37	8	142367699	142367699	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr8:142367699G>A	ENST00000377741.3	-	2	415	c.325C>T	c.(325-327)Cgc>Tgc	p.R109C		NM_005293.2	NP_005284.2	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	109						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(3)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	15	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			ACAGCGAAGCGCGTGGGCAGG	0.617000													17	68					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587657	43587657	+	RNA	SNP	C	C	T	rs148404065	by1000genomes	TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr17:43587657C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GGTGACAACACATCTGTTTTA	0.323000													3	21					0	0	1	0	0
MICALL1	85377	broad.mit.edu	37	22	38328608	38328608	+	Missense_Mutation	SNP	G	G	A	rs142424154		TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr22:38328608G>A	ENST00000215957.6	+	11	2191	c.2065G>A	c.(2065-2067)Gat>Aat	p.D689N	MICALL1_ENST00000402631.1_3'UTR	NM_033386.3	NP_203744.1	Q8N3F8	MILK1_HUMAN	MICAL-like 1	689						cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	24	Melanoma(58;0.045)					TGGAGAGATGGATACCATTGA	0.657000													21	81					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57181813	57181813	+	Silent	SNP	C	C	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr4:57181813C>T	ENST00000504228.1	+	6	2250	c.2145C>T	c.(2143-2145)gtC>gtT	p.V715V	KIAA1211_ENST00000264229.6_Silent_p.V715V|KIAA1211_ENST00000541073.1_Silent_p.V708V			Q6ZU35	K1211_HUMAN	KIAA1211	715										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CTCCGCCAGTCAATGCAAAGT	0.572000													11	86					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20585751	20585751	+	Silent	SNP	C	C	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr14:20585751C>T	ENST00000315543.4	+	1	186	c.186C>T	c.(184-186)ttC>ttT	p.F62F		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TTGCCCTCTTCTCGGTTATCT	0.413000													8	117					0	0	1	0	0
ENTPD3	956	broad.mit.edu	37	3	40468888	40468888	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr3:40468888C>A	ENST00000301825.3	+	11	1597	c.1479C>A	c.(1477-1479)ttC>ttA	p.F493L	ENTPD3-AS1_ENST00000425156.1_RNA|ENTPD3-AS1_ENST00000439293.1_RNA|ENTPD3_ENST00000456402.1_Missense_Mutation_p.F493L|ENTPD3-AS1_ENST00000452768.1_RNA	NM_001248.2	NP_001239.2	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase 3	493						integral to membrane	ATP binding|hydrolase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		CCCTCGCTTTCTTCACAGCGG	0.547000													17	29					9.16793e-09	9.81129e-09	1	1	0
APOL5	80831	broad.mit.edu	37	22	36116679	36116679	+	Silent	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr22:36116679G>A	ENST00000249044.2	+	2	120	c.120G>A	c.(118-120)ggG>ggA	p.G40G		NM_030642.1	NP_085145.1	Q9BWW9	APOL5_HUMAN	apolipoprotein L, 5	40					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|skin(2)|urinary_tract(1)	19						AGGTCTGGGGGAAGTCCccag	0.512000													3	15					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9059510	9059510	+	Silent	SNP	C	C	G			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr19:9059510C>G	ENST00000397910.4	-	3	28139	c.27936G>C	c.(27934-27936)gtG>gtC	p.V9312V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9314	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CACCAGTGGGCACACTAGAAA	0.502000													5	82					0	0	1	0	0
MICALL1	85377	broad.mit.edu	37	22	38328586	38328586	+	Silent	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr22:38328586G>A	ENST00000215957.6	+	11	2169	c.2043G>A	c.(2041-2043)gaG>gaA	p.E681E	MICALL1_ENST00000402631.1_3'UTR	NM_033386.3	NP_203744.1	Q8N3F8	MILK1_HUMAN	MICAL-like 1	681						cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	24	Melanoma(58;0.045)					ACATCCCTGAGGAGGACATCC	0.637000													29	94					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41566384	41566384	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr8:41566384G>A	ENST00000396942.1	-	17	1993	c.1910C>T	c.(1909-1911)aCg>aTg	p.T637M	ANK1_ENST00000396945.1_Missense_Mutation_p.T637M|ANK1_ENST00000352337.4_Missense_Mutation_p.T637M|ANK1_ENST00000347528.4_Missense_Mutation_p.T637M|ANK1_ENST00000289734.7_Missense_Mutation_p.T637M|ANK1_ENST00000379758.2_Missense_Mutation_p.T637M|ANK1_ENST00000265709.8_Missense_Mutation_p.T670M			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	637	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GTGAAGGGGCGTCACACCTTG	0.622000													30	59					0	0	1	0	0
SYNGR1	9145	broad.mit.edu	37	22	39770401	39770401	+	Silent	SNP	C	C	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr22:39770401C>T	ENST00000328933.5	+	2	195	c.180C>T	c.(178-180)atC>atT	p.I60I	SYNGR1_ENST00000318801.4_Silent_p.I60I|SYNGR1_ENST00000216155.7_Silent_p.I60I|SYNGR1_ENST00000406293.3_Silent_p.I60I|SYNGR1_ENST00000381535.4_Silent_p.I61I	NM_004711.4	NP_004702.2			synaptogyrin 1											endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	7	Melanoma(58;0.04)					AGTTCTGCATCTACAACCGCA	0.642000													85	129					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238245160	238245160	+	Silent	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr2:238245160G>A	ENST00000295550.4	-	40	9035	c.8583C>T	c.(8581-8583)aaC>aaT	p.N2861N	COL6A3_ENST00000353578.4_Silent_p.N2655N|COL6A3_ENST00000347401.3_Silent_p.N2660N|COL6A3_ENST00000346358.4_Silent_p.N2661N|COL6A3_ENST00000472056.1_Silent_p.N2254N|COL6A3_ENST00000409809.1_Silent_p.N2655N	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2861	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TTGAAGTAACGTTATTCGGAA	0.398000													39	28					0	0	1	0	0
FCAR	2204	broad.mit.edu	37	19	55396865	55396865	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr19:55396865C>T	ENST00000355524.3	+	3	299	c.289C>T	c.(289-291)Cgc>Tgc	p.R97C	FCAR_ENST00000359272.4_Missense_Mutation_p.R85C|FCAR_ENST00000345937.4_Missense_Mutation_p.R97C|FCAR_ENST00000469767.1_Missense_Mutation_p.R97C|FCAR_ENST00000353758.4_Intron|FCAR_ENST00000482092.2_3'UTR|FCAR_ENST00000391723.3_Missense_Mutation_p.R85C|FCAR_ENST00000391724.3_Missense_Mutation_p.R85C|FCAR_ENST00000391725.3_Missense_Mutation_p.R97C|FCAR_ENST00000391726.3_Missense_Mutation_p.R85C	NM_002000.2	NP_001991.1	P24071	FCAR_HUMAN	Fc fragment of IgA, receptor for	97	Ig-like C2-type 1.				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity	p.R97G(2)		breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(2)	24				GBM - Glioblastoma multiforme(193;0.0443)		CAAGGCAGGGCGCTATCAGTG	0.502000													6	15					0	0	1	0	0
PITRM1	10531	broad.mit.edu	37	10	3189774	3189774	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr10:3189774C>G	ENST00000380989.2	-	19	2266	c.2228G>C	c.(2227-2229)gGg>gCg	p.G743A	PITRM1_ENST00000224949.4_Missense_Mutation_p.G742A|PITRM1-AS1_ENST00000601046.1_RNA|PITRM1-AS1_ENST00000598280.1_RNA|PITRM1_ENST00000464395.1_5'UTR|PITRM1_ENST00000451104.2_Missense_Mutation_p.G644A|PITRM1_ENST00000380994.1_Missense_Mutation_p.G300A	NM_001242307.1|NM_014889.3	NP_001229236.1|NP_055704.2	E7ES23	E7ES23_HUMAN	pitrilysin metallopeptidase 1	644					proteolysis		metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|urinary_tract(3)	33						CTGATCCATCCCGCTGAAGGT	0.527000													10	87					0	0	1	0	0
APOL5	80831	broad.mit.edu	37	22	36116626	36116626	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr22:36116626G>C	ENST00000249044.2	+	2	67	c.67G>C	c.(67-69)Ggt>Cgt	p.G23R		NM_030642.1	NP_085145.1	Q9BWW9	APOL5_HUMAN	apolipoprotein L, 5	23					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|skin(2)|urinary_tract(1)	19						CTTGGGAGAAGGTTGTAAAGA	0.502000													8	19					0	0	1	0	0
CCR4	1233	broad.mit.edu	37	3	32994926	32994926	+	Silent	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr3:32994926G>A	ENST00000330953.5	+	2	180	c.12G>A	c.(10-12)acG>acA	p.T4T		NM_005508.4	NP_005499.1	P51679	CCR4_HUMAN	chemokine (C-C motif) receptor 4	4					chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response	integral to plasma membrane				NS(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)|stomach(1)	16						TGAACCCCACGGATATAGCAG	0.468000													6	20					0	0	1	0	0
PNKP	11284	broad.mit.edu	37	19	50365526	50365526	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr19:50365526G>A	ENST00000322344.3	-	12	1151	c.1042C>T	c.(1042-1044)Cgc>Tgc	p.R348C	PNKP_ENST00000600910.1_Missense_Mutation_p.R348C|PNKP_ENST00000596014.1_Missense_Mutation_p.R348C|PNKP_ENST00000600573.1_Missense_Mutation_p.R317C	NM_007254.3	NP_009185.2	Q96T60	PNKP_HUMAN	polynucleotide kinase 3'-phosphatase	348					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|urinary_tract(1)	19		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		GGCCCTGAGCGGGAGACAGTC	0.716000								Other BER factors					6	3					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175092773	175092773	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr1:175092773A>C	ENST00000239462.4	+	12	3001	c.2888A>C	c.(2887-2889)aAg>aCg	p.K963T		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	963	Fibronectin type-III 8.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CAGGAGAGCAAGAAGGCTGAC	0.622000													14	25					0	0	1	0	0
UTY	7404	broad.mit.edu	37	Y	15469761	15469761	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chrY:15469761A>T	ENST00000331397.4	-	13	2281	c.1274T>A	c.(1273-1275)tTa>tAa	p.L425*	UTY_ENST00000545955.1_Nonsense_Mutation_p.L500*|UTY_ENST00000540140.1_Nonsense_Mutation_p.L422*|UTY_ENST00000538878.1_Nonsense_Mutation_p.L392*|UTY_ENST00000537580.1_Nonsense_Mutation_p.L470*|UTY_ENST00000382896.4_Nonsense_Mutation_p.L470*|UTY_ENST00000362096.4_Nonsense_Mutation_p.L425*|UTY_ENST00000329134.5_Nonsense_Mutation_p.L425*	NM_001258267.1|NM_007125.4	NP_001245196.1|NP_009056.3	O14607	UTY_HUMAN	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	425					chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(1)|lung(6)	7						TCATACCTGTAATTTCTGTGG	0.343000													8	2					0	0	1	0	0
PPAP2B	8613	broad.mit.edu	37	1	57002733	57002733	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr1:57002733C>T	ENST00000371250.3	-	2	742	c.191G>A	c.(190-192)cGa>cAa	p.R64Q		NM_003713.4	NP_003704.3	O14495	LPP3_HUMAN	phosphatidic acid phosphatase type 2B	64					canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|germ cell migration|homotypic cell-cell adhesion|negative regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|sphingolipid metabolic process	adherens junction|Golgi apparatus|integral to membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|protein binding|sphingosine-1-phosphate phosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						GTAAAACCCTCGGTGGTAAGG	0.488000													15	28					0	0	1	0	0
GPX1	2876	broad.mit.edu	37	3	49395674	49395679	+	In_Frame_Del	DEL	GCCGCC	GCCGCC	-	rs56041243		TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr3:49395674_49395679delGCCGCC	ENST00000419783.1	-	1	354_359	c.33_38delGGCGGC	c.(31-39)gcc>gc	p.AAA11del	GPX1_ENST00000496791.1_5'UTR|GPX1_ENST00000419349.1_In_Frame_Del_p.AAA11del	NM_000581.2	NP_000572.2	P07203	GPX1_HUMAN	glutathione peroxidase 1	11					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding	p.A12_A13delAA(1)		breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CACCGACTGGgccgccgccgccgccg	0.694													3	4	---	---	---	---					
LOC101927237	101927237	broad.mit.edu	37	4	68311853	68311855	+	RNA	DEL	GAG	GAG	-			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr4:68311853_68311855delGAG	ENST00000502400.1	-	0	34																											TCTCTATGGCGAGGAGGAGGAGG	0.547													2	4	---	---	---	---					
MYO10	4651	broad.mit.edu	37	5	16764407	16764408	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr5:16764407_16764408insT	ENST00000513610.1	-	12	1731_1732	c.1277_1278insA	c.(1276-1278)gttfs	p.V426fs		NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	426	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						TAGACTTGAAGTCCTCATTGCC	0.470													11	1091	---	---	---	---					
HR	55806	broad.mit.edu	37	8	21977633	21977633	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr8:21977633delC	ENST00000381418.4	-	13	4310	c.2830delG	c.(2830-2832)atfs	p.D944fs	HR_ENST00000312841.8_Frame_Shift_Del_p.D944fs	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	944							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GTGTCCTCATCCCCCAAAGCT	0.657													2	4	---	---	---	---					
OVOS2	144203	broad.mit.edu	37	12	31270080	31270081	+	RNA	INS	-	-	AAA	rs112314315		TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr12:31270080_31270081insAAA	ENST00000542490.1	-	0	52																				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(25)|prostate(3)|stomach(3)|urinary_tract(1)	41						CGTTAAACTGGATCTCACTGGA	0.505													6	7	---	---	---	---					
HECTD4	283450	broad.mit.edu	37	12	112622883	112622885	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr12:112622883_112622885delGAG	ENST00000550722.1	-	61	9842_9844	c.9447_9449delCTC	c.(9445-9450)tcg>tc	p.SS3151del	HECTD4_ENST00000430131.2_In_Frame_Del_p.SS2875del|HECTD4_ENST00000377560.5_In_Frame_Del_p.SS3125del	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TGGGGAGGACGAGGAGGAGGAGG	0.601													2	4	---	---	---	---					
NF1	4763	broad.mit.edu	37	17	29527570	29527571	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr17:29527570_29527571insT	ENST00000358273.4	+	9	1402_1403	c.1019_1020insT	c.(1018-1020)tgtfs	p.C340fs	NF1_ENST00000431387.4_Frame_Shift_Ins_p.C340fs|NF1_ENST00000356175.3_Frame_Shift_Ins_p.C340fs	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	340					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(6)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GAAGATAACTCTGTCATTTTCC	0.381			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			12	20	---	---	---	---					
KIZ-AS1	101929591	broad.mit.edu	37	20	21142442	21142442	+	RNA	DEL	A	A	-	rs113752643		TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr20:21142442delA	ENST00000591761.1	-	0	5142				RP5-872K7.7_ENST00000425746.2_RNA|PLK1S1_ENST00000457464.1_RNA																							TCATTTCTGGAAAAAAAAAAA	0.363													2	4	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26114629	26114629	+	RNA	DEL	C	C	-			TCGA-FS-A4F4-06A-12D-A25O-08	TCGA-FS-A4F4-10B-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64DB7DA9-EAC4-4C57-9263-606F4693D72F	40B28800-15B2-4DAA-BDEA-491C7F5CDED9	g.chr20:26114629delC	ENST00000416563.1	-	0	160																											AATGCCAATACAACCAGTCAC	0.642													2	4	---	---	---	---