Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SARDH	1757	broad.mit.edu	37	9	136529067	136529067	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr9:136529067C>T	uc004cep.4	-	20	2835	c.2701G>A	c.(2701-2703)Gct>Act	p.A901T	SARDH_uc004ceo.3_Missense_Mutation_p.A901T|SARDH_uc011mdo.2_Missense_Mutation_p.A733T|SARDH_uc011mdn.2_Missense_Mutation_p.A901T|SARDH_uc004cen.3_Missense_Mutation_p.A351T	NM_001134707	NP_009032	Q9UL12	SARDH_HUMAN	Homo sapiens sarcosine dehydrogenase (SARDH), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.	901					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TTCAGGTGAGCCTGGGCACCA	0.577000													7	140					0	0	1	0	0
RPRD1A	55197	broad.mit.edu	37	18	33606928	33606928	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr18:33606928G>A	uc002kzg.3	-	5	730	c.724C>T	c.(724-726)Cga>Tga	p.R242*	RPRD1A_uc002kze.1_Nonsense_Mutation_p.R206*|RPRD1A_uc010dmw.3_Nonsense_Mutation_p.R206*|RPRD1A_uc010dmx.3_Nonsense_Mutation_p.R242*	NM_018170	NP_060640	Q96P16	RPR1A_HUMAN	Homo sapiens regulation of nuclear pre-mRNA domain containing 1A (RPRD1A), mRNA.	242								p.R242R(2)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|urinary_tract(2)	12						GCTAACATTCGAGTGAGTTGC	0.403000													6	98					0	0	1	0	0
TGDS	23483	broad.mit.edu	37	13	95248340	95248340	+	Silent	SNP	C	C	T			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr13:95248340C>T	uc001vlw.3	-	0	172	c.51G>A	c.(49-51)gcG>gcA	p.A17A		NM_014305	NP_055120	O95455	TGDS_HUMAN	Homo sapiens TDP-glucose 4,6-dehydratase (TGDS), mRNA.	17					cellular metabolic process		coenzyme binding|dTDP-glucose 4,6-dehydratase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	8	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					GGACCCGCTTCGCAAAGCCGC	0.607000													23	25					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11333436	11333436	+	Missense_Mutation	SNP	G	G	C			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr19:11333436G>C	uc002mqs.4	-	25	3256	c.3215C>G	c.(3214-3216)cCc>cGc	p.P1072R	DOCK6_uc010xlq.2_Missense_Mutation_p.P411R	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	Homo sapiens dedicator of cytokinesis 6 (DOCK6), mRNA.	1072					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						GGACACAGAGGGGGAGGGCGA	0.612000													3	3					0	0	1	0	0
FBXO18	84893	broad.mit.edu	37	10	5948520	5948520	+	Silent	SNP	C	C	T			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr10:5948520C>T	uc001iit.3	+	3	935	c.831C>T	c.(829-831)ttC>ttT	p.F277F	FBXO18_uc001iir.3_Silent_p.F152F|FBXO18_uc001iis.3_Silent_p.F226F|FBXO18_uc009xig.3_Silent_p.F152F	NM_032807	NP_835363	Q8NFZ0	FBX18_HUMAN	Homo sapiens F-box protein, helicase, 18 (FBXO18), transcript variant 1, mRNA.	226					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						TGTTTGCCTTCCTCCCGGTGG	0.572000													7	142					0	0	1	0	0
ZNF709	163051	broad.mit.edu	37	19	12637690	12637690	+	Missense_Mutation	SNP	T	T	A			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr19:12637690T>A	uc002mty.3	-	3	1442	c.1232A>T	c.(1231-1233)cAc>cTc	p.H411L	ZNF709_uc002mtx.4_Intron	NM_144976	NP_659413	Q8N972	ZN709_HUMAN	Homo sapiens zinc finger protein 564 (ZNF564), mRNA.	466					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|upper_aerodigestive_tract(3)	6						AGTTCTTTCGTGTATTTGAAA	0.408000													26	246					0	0	1	0	0
POMT2	29954	broad.mit.edu	37	14	77778315	77778315	+	Missense_Mutation	SNP	C	C	G			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr14:77778315C>G	uc001xti.2	-	1	511	c.310G>C	c.(310-312)Gat>Cat	p.D104H	POMT2_uc010asr.2_Intron	NM_013382	NP_037514	Q9UKY4	POMT2_HUMAN	Homo sapiens protein-O-mannosyltransferase 2 (POMT2), mRNA.	104					protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			breast(2)|endometrium(2)|large_intestine(1)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	14			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		GGGTGCACATCAAAGAAAAAT	0.433000													15	41					0	0	1	0	0
TRAF3IP3	80342	broad.mit.edu	37	1	209933458	209933458	+	Missense_Mutation	SNP	G	G	C			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr1:209933458G>C	uc001hho.3	+	2	494	c.74G>C	c.(73-75)cGc>cCc	p.R25P	TRAF3IP3_uc001hhm.2_Missense_Mutation_p.R25P|TRAF3IP3_uc001hhn.3_Missense_Mutation_p.R25P|TRAF3IP3_uc009xcr.3_Missense_Mutation_p.R25P	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	Homo sapiens TRAF3 interacting protein 3 (TRAF3IP3), mRNA.	25						integral to membrane	protein binding	p.R25C(1)		breast(2)|endometrium(1)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32				OV - Ovarian serous cystadenocarcinoma(81;0.045)		AAGTGTGAGCGCAGGCAAGAG	0.627000													4	49					0	0	1	0	0
POMT2	29954	broad.mit.edu	37	14	77778367	77778367	+	Silent	SNP	C	C	T			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr14:77778367C>T	uc001xti.2	-	1	459	c.258G>A	c.(256-258)gaG>gaA	p.E86E	POMT2_uc010asr.2_Intron	NM_013382	NP_037514	Q9UKY4	POMT2_HUMAN	Homo sapiens protein-O-mannosyltransferase 2 (POMT2), mRNA.	86					protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			breast(2)|endometrium(2)|large_intestine(1)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	14			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		CAAAGTGAGTCTCATCCCAAC	0.373000													20	36					0	0	1	0	0
TDRD7	23424	broad.mit.edu	37	9	100245294	100245294	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr9:100245294C>T	uc004axj.3	+	14	2801	c.2576C>T	c.(2575-2577)tCt>tTt	p.S859F	TDRD7_uc011lux.2_Missense_Mutation_p.S785F|TDRD7_uc010msp.1_Missense_Mutation_p.S111F|TDRD7_uc011luy.2_Missense_Mutation_p.S179F	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	Homo sapiens tudor domain containing 7 (TDRD7), mRNA.	859					lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Acute lymphoblastic leukemia(62;0.158)				GGAGCTGACTCTCCCAACAGC	0.463000													40	51					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64967027	64967027	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr10:64967027G>A	uc001jmn.3	-	9	4702	c.4402C>T	c.(4402-4404)Caa>Taa	p.Q1468*	JMJD1C_uc001jml.3_Nonsense_Mutation_p.Q1249*|JMJD1C_uc001jmm.3_Nonsense_Mutation_p.Q1180*|JMJD1C_uc010qiq.2_Nonsense_Mutation_p.Q1286*|JMJD1C_uc009xpi.3_Nonsense_Mutation_p.Q1286*|JMJD1C_uc009xpj.2_Non-coding_Transcript|JMJD1C_uc009xpk.1_Nonsense_Mutation_p.Q505*	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	Homo sapiens jumonji domain containing 1C (JMJD1C), transcript variant 1, mRNA.	1468					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					GAACTGGGTTGAACAACACTT	0.433000													76	98					0	0	1	0	0
ZFAND5	7763	broad.mit.edu	37	9	74971943	74971943	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr9:74971943G>A	uc010moy.1	-	4	678	c.397C>T	c.(397-399)Cag>Tag	p.Q133*	ZFAND5_uc010mox.1_Nonsense_Mutation_p.Q30*|ZFAND5_uc004aix.2_Nonsense_Mutation_p.Q133*|ZFAND5_uc004aiw.2_Nonsense_Mutation_p.Q133*|ZFAND5_uc004aiy.2_Nonsense_Mutation_p.Q133*	NM_006007	NP_005998	O76080	ZFAN5_HUMAN	Homo sapiens zinc finger, AN1-type domain 5 (ZFAND5), transcript variant c, mRNA.	133							DNA binding|zinc ion binding	p.Q133*(2)|p.Q133Q(1)		cervix(1)|kidney(2)|lung(2)|prostate(1)	6						GTACTGGGCTGAGAAACTGAT	0.383000													35	51					0	0	1	0	0
RIOK2	55781	broad.mit.edu	37	5	96498929	96498929	+	Splice_Site	SNP	C	C	T			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr5:96498929C>T	uc003kmz.3	-	10	1605	c.1495_splice	c.e10-1	p.E499_splice		NM_018343	NP_060813	Q9BVS4	RIOK2_HUMAN	Homo sapiens RIO kinase 2 (yeast) (RIOK2), transcript variant 1, mRNA.	499	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|urinary_tract(2)	23		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		TTCACCAGTTCCTGGAAAGAT	0.328000													39	49					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	26107935	26107935	+	Silent	SNP	C	C	T			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr15:26107935C>T	uc010ayu.3	-	0	415	c.309G>A	c.(307-309)gtG>gtA	p.V103V	ATP10A_uc001zax.3_Non-coding_Transcript	NM_024490	NP_077816	O60312	AT10A_HUMAN	Homo sapiens ATPase, class V, type 10A (ATP10A), mRNA.	103					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GGAAGGCGTTCACCGCCGGCA	0.652000													6	14					0	0	1	0	0
MOS	4342	broad.mit.edu	37	8	57026479	57026479	+	Silent	SNP	C	C	T			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr8:57026479C>T	uc011leb.2	-	0	63	c.63G>A	c.(61-63)gcG>gcA	p.A21A		NM_005372	NP_005363	P00540	MOS_HUMAN	Homo sapiens v-mos Moloney murine sarcoma viral oncogene homolog (MOS), mRNA.	21							ATP binding|protein binding|protein serine/threonine kinase activity	p.A21A(2)		breast(1)|central_nervous_system(1)|large_intestine(5)|lung(12)|ovary(1)|urinary_tract(2)	22			Epithelial(17;0.00117)|all cancers(17;0.00879)			TGCAGGGCCGCGCGTCCACCG	0.706000													23	36					0	0	1	0	0
LPAR6	10161	broad.mit.edu	37	13	48985608	48985608	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr13:48985608C>T	uc010acu.3	-	0	2046	c.952G>A	c.(952-954)Gaa>Aaa	p.E318K	RB1_uc001vcb.3_Intron|LPAR6_uc001vcc.1_Intron|LPAR6_uc001vce.3_Missense_Mutation_p.E318K|LPAR6_uc001vcf.3_Missense_Mutation_p.E318K	NM_001162498	NP_005758	P43657	LPAR6_HUMAN	Homo sapiens lysophosphatidic acid receptor 6 (LPAR6), transcript variant 3, mRNA.	318						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.0?(15)|p.?(4)		NS(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	14						CCATGAACTTCAGAGAATCTG	0.343000													66	87					0	0	1	0	0
LMAN2L	81562	broad.mit.edu	37	2	97405604	97405604	+	Silent	SNP	C	C	T			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr2:97405604C>T	uc002swv.3	-	0	210	c.174G>A	c.(172-174)tcG>tcA	p.S58S	LMAN2L_uc002swu.3_Silent_p.S58S|LMAN2L_uc010yuu.2_5'UTR|LMAN2L_uc010yut.2_5'UTR|LMAN2L_uc010yuv.2_5'UTR|LMAN2L_uc010yuw.2_5'UTR|LMAN2L_uc010yux.2_5'UTR	NM_001142292	NP_001135764	Q9H0V9	LMA2L_HUMAN	Homo sapiens lectin, mannose-binding 2-like (LMAN2L), transcript variant 1, mRNA.	58	L-type lectin-like.				ER to Golgi vesicle-mediated transport|protein folding|protein transport	ER to Golgi transport vesicle|Golgi membrane|endoplasmic reticulum membrane|integral to membrane	mannose binding|metal ion binding			NS(1)|breast(1)|endometrium(1)|lung(2)|skin(1)|urinary_tract(1)	7						GGTAGGGCTTCGACAGCGAGT	0.627000													33	51					0	0	1	0	0
FAM84A	151354	broad.mit.edu	37	2	14774447	14774447	+	Missense_Mutation	SNP	C	C	T			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr2:14774447C>T	uc002rbz.2	+	1	632	c.344C>T	c.(343-345)gCg>gTg	p.A115V	FAM84A_uc021ved.1_Missense_Mutation_p.A115V|AX747684_uc002rca.1_5'Flank	NM_145175	NP_660158	Q96KN4	FA84A_HUMAN	Homo sapiens family with sequence similarity 84, member A (FAM84A), mRNA.	115										endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(1;0.00969)			GCGGTCACCGCGCTGCCAGCG	0.692000													5	14					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111965622	111965622	+	Missense_Mutation	SNP	G	G	C			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr1:111965622G>C	uc001eba.3	-	5	591	c.535C>G	c.(535-537)Ctg>Gtg	p.L179V	OVGP1_uc001eaz.3_Missense_Mutation_p.L141V|OVGP1_uc010owb.2_5'UTR	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	Homo sapiens oviductal glycoprotein 1, 120kDa (OVGP1), mRNA.	179					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		GACAGCAGCAGCCTCGGGCGC	0.542000													110	106					0	0	1	0	0
O3FAR1	338557	broad.mit.edu	37	10	95326832	95326832	+	Missense_Mutation	SNP	A	A	G			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr10:95326832A>G	uc010qnt.2	+	0	411	c.355A>G	c.(355-357)Acc>Gcc	p.T119A	O3FAR1_uc010qnu.2_Missense_Mutation_p.T119A	NM_181745	NP_859529	Q5NUL3	O3FA1_HUMAN	Homo sapiens omega-3 fatty acid receptor 1 (O3FAR1), transcript variant 1, mRNA.	119					negative regulation of cytokine secretion|negative regulation of inflammatory response|regulation of glucose transport	integral to membrane|plasma membrane	fatty acid binding			breast(1)|endometrium(1)|kidney(2)|lung(6)|prostate(2)	12						CTACGTGATGACCCTGAGCGG	0.687000													18	24					0	0	1	0	0
SPIB	6689	broad.mit.edu	37	19	50931366	50931366	+	Missense_Mutation	SNP	G	G	A			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr19:50931366G>A	uc002psd.3	+	5	587	c.562G>A	c.(562-564)Gtg>Atg	p.V188M	SPIB_uc021uyc.1_Missense_Mutation_p.V157M|SPIB_uc002pse.3_3'UTR|SPIB_uc010ycc.2_Missense_Mutation_p.V97M	NM_003121	NP_003112	Q01892	SPIB_HUMAN	Homo sapiens Spi-B transcription factor (Spi-1/PU.1 related) (SPIB), transcript variant 1, mRNA.	188					regulation of transcription from RNA polymerase II promoter	cytoplasm|microtubule cytoskeleton|nucleus	sequence-specific DNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)	14		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		GCGTGAGTGCGTGTGGTGGGT	0.682000													3	3					0	0	1	0	0
VAPA	9218	broad.mit.edu	37	18	9950521	9950521	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr18:9950521C>T	uc002koj.3	+	5	981	c.682C>T	c.(682-684)Cag>Tag	p.Q228*	VAPA_uc002kok.3_Nonsense_Mutation_p.Q183*	NM_003574	NP_003565	Q9P0L0	VAPA_HUMAN	Homo sapiens VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa (VAPA), transcript variant 1, mRNA.	183					cell death|cellular membrane fusion|neuron projection development|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein localization in endoplasmic reticulum|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane|vesicle	protein heterodimerization activity|signal transducer activity|structural molecule activity			breast(1)|lung(2)|prostate(1)	4						TAAAAGACTTCAGGGAGAAAT	0.378000													47	41					0	0	1	0	0
TGFBR3	7049	broad.mit.edu	37	1	92200373	92200373	+	Silent	SNP	T	T	C			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr1:92200373T>C	uc001doh.3	-	4	1043	c.528A>G	c.(526-528)gaA>gaG	p.E176E	TGFBR3_uc009wde.3_5'UTR|TGFBR3_uc010osy.2_Silent_p.E134E|TGFBR3_uc001doi.3_Silent_p.E176E|TGFBR3_uc001doj.3_Silent_p.E176E	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	Homo sapiens transforming growth factor, beta receptor III (TGFBR3), transcript variant 1, mRNA.	176					BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	PDZ domain binding|SMAD binding|coreceptor activity|heparin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(24)|ovary(3)|prostate(4)|skin(1)|stomach(1)|urinary_tract(3)	55		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		CTATCTTGAGTTCGGTGAATG	0.378000													13	308					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	185929649	185929649	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr3:185929649C>A	uc003fqa.3	-	20	2389	c.1852G>T	c.(1852-1854)Gaa>Taa	p.E618*	DGKG_uc003fqb.3_Nonsense_Mutation_p.E579*|DGKG_uc003fqc.3_Nonsense_Mutation_p.E593*|DGKG_uc011brx.2_Nonsense_Mutation_p.E559*	NM_001346	NP_001337	P49619	DGKG_HUMAN	Homo sapiens diacylglycerol kinase, gamma 90kDa (DGKG), transcript variant 1, mRNA.	618					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	GTGCCAAATTCAAAGTACCAC	0.453000													4	100					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128134235	128134238	+	Frame_Shift_Del	DEL	ACTA	ACTA	-	rs150659844		TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr6:128134235_128134238delACTA	uc011ebt.2	-	3	1697_1700	c.1548_1551delTAGT	c.(1546-1551)gttagtfs	p.V516fs	THEMIS_uc010kfa.3_Frame_Shift_Del_p.V419fs|THEMIS_uc021zfa.1_Frame_Shift_Del_p.V516fs|THEMIS_uc010kfb.3_Frame_Shift_Del_p.V481fs	NM_001164685	NP_001158157	Q8N1K5	THMS1_HUMAN	Homo sapiens thymocyte selection associated (THEMIS), transcript variant 1, mRNA.	516	CABIT 2.				T cell receptor signaling pathway|negative T cell selection|positive T cell selection	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						TAGAGAAATTACTAACTAACTGAA	0.441													50	76	---	---	---	---					
PLEC	5339	broad.mit.edu	37	8	145009091	145009091	+	Frame_Shift_Del	DEL	G	G	-	rs137853160		TCGA-DE-A0Y2-01A-11D-A10S-08	TCGA-DE-A0Y2-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3423951-7bef-4dbe-be7c-c46c37ed2ffb	aef4af62-4d81-4cdb-9cd8-069dd8a3b6e7	g.chr8:145009091delG	uc003zaf.1	-	8	1413	c.1243delC	c.(1243-1245)cagfs	p.Q415fs	PLEC_uc003zab.1_Frame_Shift_Del_p.Q278fs|PLEC_uc003zac.1_Frame_Shift_Del_p.Q282fs|PLEC_uc003zad.2_Frame_Shift_Del_p.Q278fs|PLEC_uc003zae.1_Frame_Shift_Del_p.Q246fs|PLEC_uc003zag.1_Frame_Shift_Del_p.Q256fs|PLEC_uc003zah.2_Frame_Shift_Del_p.Q264fs|PLEC_uc003zaj.2_Frame_Shift_Del_p.Q305fs	NM_201380	NP_958782	Q15149	PLEC_HUMAN	Homo sapiens plectin (PLEC), transcript variant 6, mRNA.	415	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CAGCGCAGCTGCAGCTCCTGC	0.706													19	31	---	---	---	---