Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AMPD2	271	broad.mit.edu	37	1	110170763	110170763	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A1QD-01A-11D-A14W-08	TCGA-DJ-A1QD-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02432cdc-0578-4137-a58f-1283ba3cff5b	c370d1ca-9037-4ff8-98a8-201c758d33a5	g.chr1:110170763T>C	uc009wfh.1	+	10	1843	c.1301T>C	c.(1300-1302)aTc>aCc	p.I434T	AMPD2_uc009wfg.1_Non-coding_Transcript|AMPD2_uc001dyb.1_Missense_Mutation_p.I353T|AMPD2_uc001dyc.1_Missense_Mutation_p.I434T|AMPD2_uc010ovr.1_Missense_Mutation_p.I359T|AMPD2_uc010ovs.1_Missense_Mutation_p.I316T|AMPD2_uc001dyd.1_Missense_Mutation_p.I315T|AMPD2_uc001dye.1_5'Flank	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	Homo sapiens adenosine monophosphate deaminase 2 (AMPD2), transcript variant 1, mRNA.	434					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			breast(1)|large_intestine(3)|ovary(2)|skin(1)	7		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		CTGCGCTTCATCAAGCGGGCA	0.597000													4	20					0	0	1	0	0
KLHL10	317719	broad.mit.edu	37	17	40001678	40001678	+	Missense_Mutation	SNP	C	C	A			TCGA-DJ-A1QD-01A-11D-A14W-08	TCGA-DJ-A1QD-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02432cdc-0578-4137-a58f-1283ba3cff5b	c370d1ca-9037-4ff8-98a8-201c758d33a5	g.chr17:40001678C>A	uc010cxr.3	+	2	1127	c.985C>A	c.(985-987)Cgt>Agt	p.R329S	KLHL10_uc010wfv.1_Missense_Mutation_p.R323S|KLHL10_uc010wfw.2_Missense_Mutation_p.R241S	NM_152467	NP_689680	Q6JEL2	KLH10_HUMAN	Homo sapiens kelch-like 10 (Drosophila) (KLHL10), mRNA.	329						cytoplasm				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26		Breast(137;0.000162)				AGAGAGTCCCCGTGCCTACCA	0.493000													3	54					0	0	1	0	0
SPINK9	643394	broad.mit.edu	37	5	147716006	147716006	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A1QD-01A-11D-A14W-08	TCGA-DJ-A1QD-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02432cdc-0578-4137-a58f-1283ba3cff5b	c370d1ca-9037-4ff8-98a8-201c758d33a5	g.chr5:147716006C>T	uc003lpe.1	+	1	132	c.77C>T	c.(76-78)aCg>aTg	p.T26M	AK054753_uc003lpb.1_Intron	NM_001040433	NP_001035523	Q5DT21	ISK9_HUMAN	Homo sapiens serine peptidase inhibitor, Kazal type 9 (SPINK9), mRNA.	26	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)|urinary_tract(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCAAACAGACGAAACAGATG	0.303000													24	88					0	0	1	0	0
KIAA1432	57589	broad.mit.edu	37	9	5765543	5765543	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A1QD-01A-11D-A14W-08	TCGA-DJ-A1QD-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02432cdc-0578-4137-a58f-1283ba3cff5b	c370d1ca-9037-4ff8-98a8-201c758d33a5	g.chr9:5765543G>A	uc003zjl.4	+	18	3051	c.2860G>A	c.(2860-2862)Gag>Aag	p.E954K	KIAA1432_uc003zjh.3_Missense_Mutation_p.E912K|KIAA1432_uc003zji.3_Missense_Mutation_p.E912K|KIAA1432_uc003zjj.1_Missense_Mutation_p.E454K	NM_001206557	NP_001193486	Q4ADV7	RIC1_HUMAN	Homo sapiens KIAA1432 (KIAA1432), transcript variant 3, mRNA.	991						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TGGAGAATCTGAGACACCTCC	0.458000													17	168					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DJ-A1QD-01A-11D-A14W-08	TCGA-DJ-A1QD-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02432cdc-0578-4137-a58f-1283ba3cff5b	c370d1ca-9037-4ff8-98a8-201c758d33a5	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				18	41					0	0	1	0	0
VNN2	8875	broad.mit.edu	37	6	133070907	133070907	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A1QD-01A-11D-A14W-08	TCGA-DJ-A1QD-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02432cdc-0578-4137-a58f-1283ba3cff5b	c370d1ca-9037-4ff8-98a8-201c758d33a5	g.chr6:133070907C>T	uc003qdt.3	-	5	1309	c.1298G>A	c.(1297-1299)gGc>gAc	p.G433D	VNN2_uc003qds.3_Missense_Mutation_p.G142D|VNN2_uc010kgb.3_Missense_Mutation_p.G212D|VNN2_uc003qdv.3_Missense_Mutation_p.G380D	NM_004665	NP_004656	O95498	VNN2_HUMAN	Homo sapiens vanin 2 (VNN2), transcript variant 1, mRNA.	433					cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		TCCAAATGTGCCACTGAGGGA	0.393000													3	40					0	0	1	0	0
TMEM176B	28959	broad.mit.edu	37	7	150493471	150493471	+	Missense_Mutation	SNP	C	C	T	rs141592438	byFrequency	TCGA-DJ-A1QD-01A-11D-A14W-08	TCGA-DJ-A1QD-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02432cdc-0578-4137-a58f-1283ba3cff5b	c370d1ca-9037-4ff8-98a8-201c758d33a5	g.chr7:150493471C>T	uc022apx.1	-	0	313	c.187G>A	c.(187-189)Gag>Aag	p.E63K	TMEM176B_uc003whu.4_Missense_Mutation_p.E63K|TMEM176B_uc003whv.4_Missense_Mutation_p.E63K|TMEM176B_uc003whw.4_Missense_Mutation_p.E63K	NM_014020	NP_054739	Q3YBM2	T176B_HUMAN	Homo sapiens transmembrane protein 176B (TMEM176B), transcript variant 1, mRNA.	63					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane		p.E63Q(2)		cervix(1)|large_intestine(4)|lung(10)|ovary(1)|skin(3)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCCAGCTGCTCATAACCAATC	0.498000													21	36					0	0	1	0	0
BIN2	51411	broad.mit.edu	37	12	51696492	51696492	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A1QD-01A-11D-A14W-08	TCGA-DJ-A1QD-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02432cdc-0578-4137-a58f-1283ba3cff5b	c370d1ca-9037-4ff8-98a8-201c758d33a5	g.chr12:51696492T>C	uc001ryg.3	-	3	342	c.290A>G	c.(289-291)gAg>gGg	p.E97G	BIN2_uc009zlz.3_Missense_Mutation_p.E97G|BIN2_uc001ryh.3_5'UTR|BIN2_uc010sng.2_Missense_Mutation_p.E71G	NM_016293	NP_057377	Q9UBW5	BIN2_HUMAN	Homo sapiens bridging integrator 2 (BIN2), mRNA.	97	BAR.					cytoplasm	protein binding			NS(2)|breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(3)	31						CTTCAGCTCCTCATGACCGTC	0.468000													3	164					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89401667	89401667	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A1QD-01A-11D-A14W-08	TCGA-DJ-A1QD-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02432cdc-0578-4137-a58f-1283ba3cff5b	c370d1ca-9037-4ff8-98a8-201c758d33a5	g.chr15:89401667G>A	uc010upo.1	+	11	6225	c.5851G>A	c.(5851-5853)Gcc>Acc	p.A1951T	ACAN_uc010upp.1_Missense_Mutation_p.A1951T|ACAN_uc002bna.2_Non-coding_Transcript	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	Homo sapiens aggrecan (ACAN), transcript variant 2, mRNA.	1951					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGCTCCAACAGCCCAAGAGGC	0.517000													13	64					0	0	1	0	0
CCDC132	55610	broad.mit.edu	37	7	92869233	92869233	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A1QD-01A-11D-A14W-08	TCGA-DJ-A1QD-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02432cdc-0578-4137-a58f-1283ba3cff5b	c370d1ca-9037-4ff8-98a8-201c758d33a5	g.chr7:92869233C>T	uc003umo.3	+	1	216	c.88C>T	c.(88-90)Cgg>Tgg	p.R30W	CCDC132_uc003ump.3_5'UTR|CCDC132_uc003umr.3_Non-coding_Transcript|CCDC132_uc011khz.2_Missense_Mutation_p.R30W|CCDC132_uc003umn.3_Missense_Mutation_p.R30W	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	Homo sapiens coiled-coil domain containing 132 (CCDC132), transcript variant 1, mRNA.	30										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			AGAGAGTCTCCGGGTCCCTGG	0.393000													3	79					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228437938	228437938	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A1QD-01A-11D-A14W-08	TCGA-DJ-A1QD-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02432cdc-0578-4137-a58f-1283ba3cff5b	c370d1ca-9037-4ff8-98a8-201c758d33a5	g.chr1:228437938G>A	uc009xez.1	+	13	4350	c.4306G>A	c.(4306-4308)Gca>Aca	p.A1436T	OBSCN_uc001hsn.3_Missense_Mutation_p.A1436T	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	Homo sapiens obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (OBSCN), transcript variant 2, mRNA.	1436					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	M band|Z disc|cytosol	ATP binding|Rho guanyl-nucleotide exchange factor activity|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CCTGGACGTGGCAGGTCAGTG	0.632000													4	106					0	0	1	0	0