Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DMP1	1758	broad.mit.edu	37	4	88584444	88584444	+	Missense_Mutation	SNP	A	A	T			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr4:88584444A>T	uc003hqv.3	+	5	1618	c.1514A>T	c.(1513-1515)gAt>gTt	p.D505V	DMP1_uc003hqw.3_Missense_Mutation_p.D489V	NM_004407	NP_004398	Q13316	DMP1_HUMAN	Homo sapiens dentin matrix acidic phosphoprotein 1 (DMP1), transcript variant 1, mRNA.	505					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		GGGGACCAAGATGACAATGAC	0.413000													56	88					0	0	1	0	0
HIST1H4J	8363	broad.mit.edu	37	6	27791912	27791912	+	Missense_Mutation	SNP	C	C	G			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr6:27791912C>G	uc003njp.3	+	0	10	c.10C>G	c.(10-12)Cgc>Ggc	p.R4G	FKSG63_uc003njq.2_5'Flank	NM_021968	NP_778224	P62805	H4_HUMAN	Homo sapiens histone cluster 1, H4j (HIST1H4J), mRNA.	4					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(2)|ovary(1)|pancreas(1)	4						CATGTCTGGCCGCGGCAAAGG	0.612000													10	24					0	0	1	0	0
MS4A12	54860	broad.mit.edu	37	11	60274284	60274284	+	Silent	SNP	C	C	G			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr11:60274284C>G	uc001npr.3	+	5	729	c.672C>G	c.(670-672)gcC>gcG	p.A224A	MS4A12_uc021qkb.1_Silent_p.A178A	NM_017716	NP_060186	Q9NXJ0	M4A12_HUMAN	Homo sapiens membrane-spanning 4-domains, subfamily A, member 12 (MS4A12), transcript variant 1, mRNA.	224						integral to membrane	receptor activity			breast(1)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)	17						CCCATTTTGCCAACCAAGCAA	0.418000													11	39					0	0	1	0	0
TMEM38B	55151	broad.mit.edu	37	9	108483839	108483839	+	Silent	SNP	G	G	A	rs141978983		TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr9:108483839G>A	uc004bcu.1	+	2	408	c.291G>A	c.(289-291)ccG>ccA	p.P97P	TMEM38B_uc010mtn.1_Intron	NM_018112	NP_060582	Q9NVV0	TM38B_HUMAN	Homo sapiens transmembrane protein 38B (TMEM38B), mRNA.	97						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	13						TTTTTTGCCCGCATGACCTAG	0.353000													3	38					0	0	1	0	0
TMEM101	84336	broad.mit.edu	37	17	42090386	42090386	+	Silent	SNP	G	G	T			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr17:42090386G>T	uc002ieu.3	-	2	481	c.456C>A	c.(454-456)ctC>ctA	p.L152L	TMEM101_uc010wis.2_Silent_p.L94L	NM_032376	NP_115752	Q96IK0	TM101_HUMAN	Homo sapiens transmembrane protein 101 (TMEM101), mRNA.	152					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		Breast(137;0.0264)|Prostate(33;0.0861)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CCACACAGATGAGGTAGATAC	0.597000													3	29					0	0	1	0	0
MBD6	114785	broad.mit.edu	37	12	57919484	57919484	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr12:57919484C>T	uc001soj.1	+	5	957	c.733C>T	c.(733-735)Cct>Tct	p.P245S	MBD6_uc001sok.1_Missense_Mutation_p.P112S|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	Homo sapiens methyl-CpG binding domain protein 6 (MBD6), mRNA.	245	Pro-rich.					chromosome|nucleus	DNA binding|chromatin binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|urinary_tract(1)	31						CCTGGGCTCTCCTCCGGCCCC	0.612000													4	226					0	0	1	0	0
INHBC	3626	broad.mit.edu	37	12	57843479	57843479	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr12:57843479A>G	uc001snv.1	+	1	860	c.733A>G	c.(733-735)Agg>Ggg	p.R245G		NM_005538	NP_005529	P55103	INHBC_HUMAN	Homo sapiens inhibin, beta C (INHBC), mRNA.	245					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						AGGAGGGTCCAGGATGTGCTG	0.577000													19	48					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152328852	152328852	+	Silent	SNP	C	C	T			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr1:152328852C>T	uc001ezw.4	-	2	1483	c.1410G>A	c.(1408-1410)ggG>ggA	p.G470G	AK056431_uc001ezv.3_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	Homo sapiens filaggrin family member 2 (FLG2), mRNA.	470	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGAGCTAGACCCATGCTGGT	0.522000													6	145					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091784	29091784	+	Missense_Mutation	SNP	C	C	A			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr22:29091784C>A	uc003adt.1	-	11	1374	c.1302G>T	c.(1300-1302)ttG>ttT	p.L434F	CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_Non-coding_Transcript|CHEK2_uc010gvk.1_Non-coding_Transcript|CHEK2_uc003ads.1_Missense_Mutation_p.L170F|CHEK2_uc010gvh.1_Missense_Mutation_p.L300F|CHEK2_uc010gvi.1_Intron|CHEK2_uc003adu.1_Missense_Mutation_p.L391F|CHEK2_uc003adv.1_Missense_Mutation_p.L362F|CHEK2_uc003adx.1_Missense_Mutation_p.L170F	NM_001005735	NP_001005735	O96017	CHK2_HUMAN	Homo sapiens checkpoint kinase 2 (CHEK2), transcript variant 3, mRNA.	391	Protein kinase.				DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|cell cycle|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CTTCAGGCGCCAAGTAGGTGG	0.423000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					26	14					0	0	1	0	0
ITGA10	8515	broad.mit.edu	37	1	145534935	145534935	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr1:145534935G>A	uc001eoa.3	+	14	1914	c.1838G>A	c.(1837-1839)cGa>cAa	p.R613Q	ITGA10_uc010oyv.2_Missense_Mutation_p.R482Q|ITGA10_uc009wiw.3_Missense_Mutation_p.R470Q|ITGA10_uc010oyw.2_Missense_Mutation_p.R558Q	NM_003637	NP_003628	O75578	ITA10_HUMAN	Homo sapiens integrin, alpha 10 (ITGA10), mRNA.	613					cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity	p.R613Q(2)|p.G612S(1)		NS(1)|breast(2)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TACTTTGGCCGAAGTGTGGAT	0.577000													33	73					0	0	1	0	0
NOMO1	23420	broad.mit.edu	37	16	14958553	14958553	+	Missense_Mutation	SNP	G	G	T			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr16:14958553G>T	uc002dcv.3	+	12	1573	c.1507G>T	c.(1507-1509)Gca>Tca	p.A503S		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	Homo sapiens NODAL modulator 1 (NOMO1), mRNA.	503						integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(6)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|skin(2)	30						ACAGTTCTTGGCATCAGTTTC	0.468000													63	151					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	rs11554290		TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr1:115256529T>C	uc009wgu.3	-	2	436	c.182A>G	c.(181-183)cAa>cGa	p.Q61R		NM_002524	NP_002515	P01111	RASN_HUMAN	Homo sapiens neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS), mRNA.	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		Ras protein signal transduction|activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(1713)|p.Q61K(635)|p.Q61L(370)|p.Q61H(123)|p.Q61P(46)|p.Q61E(9)|p.G60E(6)|p.Q61?(5)|p.Q61Q(3)|p.G60R(1)|p.G60>?(1)|p.Q61*(1)|p.Q61_E62>HK(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			55	106					0	0	1	0	0
ICAM3	3385	broad.mit.edu	37	19	10449575	10449575	+	Silent	SNP	C	C	T			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr19:10449575C>T	uc002mob.2	-	1	181	c.126G>A	c.(124-126)gtG>gtA	p.V42V	ICAM3_uc010dxd.1_5'UTR|ICAM3_uc010xlf.1_Intron	NM_002162	NP_002153	P32942	ICAM3_HUMAN	Homo sapiens intercellular adhesion molecule 3 (ICAM3), mRNA.	42					cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	13			OV - Ovarian serous cystadenocarcinoma(20;6.13e-09)|Epithelial(33;9.69e-06)|all cancers(31;2.05e-05)			CAGCAGAGAGCACAGGGTTCT	0.552000													22	37					0	0	1	0	0
C6orf211	79624	broad.mit.edu	37	6	151779565	151779565	+	Missense_Mutation	SNP	G	G	C			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr6:151779565G>C	uc003qok.1	+	2	509	c.250G>C	c.(250-252)Gat>Cat	p.D84H	C6orf211_uc011ees.1_5'UTR	NM_024573	NP_078849	Q9H993	CF211_HUMAN	Homo sapiens chromosome 6 open reading frame 211 (C6orf211), mRNA.	84							protein binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(7)	15			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)		GAAATTTGTTGATACTGATAT	0.363000													29	50					0	0	1	0	0
THBS2	7058	broad.mit.edu	37	6	169637364	169637364	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr6:169637364G>A	uc003qwt.3	-	9	1626	c.1378C>T	c.(1378-1380)Cgc>Tgc	p.R460C		NM_003247	NP_003238	P35442	TSP2_HUMAN	Homo sapiens thrombospondin 2 (THBS2), mRNA.	460	TSP type-1 2.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		AGACGGATGCGTGTGATATTG	0.607000													23	25					0	0	1	0	0
HTR3A	3359	broad.mit.edu	37	11	113853948	113853948	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr11:113853948A>G	uc010rxb.2	+	4	732	c.499A>G	c.(499-501)Atc>Gtc	p.I167V	HTR3A_uc010rxa.2_Missense_Mutation_p.I167V|HTR3A_uc009yyx.3_Non-coding_Transcript|HTR3A_uc010rxc.2_Missense_Mutation_p.I146V	NM_213621	NP_998786	P46098	5HT3A_HUMAN	Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3A (HTR3A), transcript variant 1, mRNA.	161					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	TAGCCTCGACATCTACAACTT	0.547000													9	142					0	0	1	0	0
PLCD4	84812	broad.mit.edu	37	2	219501103	219501103	+	Missense_Mutation	SNP	T	T	A			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr2:219501103T>A	uc021vwx.1	+	14	2509	c.2170T>A	c.(2170-2172)Tgc>Agc	p.C724S		NM_032726	NP_116115	Q9BRC7	PLCD4_HUMAN	Homo sapiens phospholipase C, delta 4 (PLCD4), mRNA.	724					intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GCCTTGGACCTGCATGCAACA	0.552000													4	267					0	0	1	0	0
PPCS	79717	broad.mit.edu	37	1	42925432	42925432	+	Silent	SNP	T	T	C			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr1:42925432T>C	uc001chl.3	+	2	835	c.771T>C	c.(769-771)gcT>gcC	p.A257A	PPCS_uc001chk.3_Silent_p.A84A	NM_024664	NP_078940	Q9HAB8	PPCS_HUMAN	Homo sapiens phosphopantothenoylcysteine synthetase (PPCS), transcript variant 1, mRNA.	257					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|skin(3)	12	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TGGTGGTGGCTAATATCCTTG	0.398000													3	137					0	0	1	0	0
C16orf91	283951	broad.mit.edu	37	16	1470345	1470345	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr16:1470345C>T	uc010uvd.2	-	3	772	c.772G>A	c.(772-774)Gcg>Acg	p.A258T	C16orf91_uc002clr.3_Missense_Mutation_p.A101T	NM_001010878	NP_001010878	Q4G0I0	CSMT1_HUMAN	Homo sapiens chromosome 16 open reading frame 91 (C16orf91), mRNA.	101						integral to membrane		p.E257K(1)		breast(1)|endometrium(1)|kidney(1)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11						CACTGGTCCGCCTCGCTCTCC	0.617000													41	73					0	0	1	0	0
PTPN2	5771	broad.mit.edu	37	18	12817199	12817199	+	Missense_Mutation	SNP	C	C	A			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr18:12817199C>A	uc002krp.3	-	5	855	c.661G>T	c.(661-663)Ggg>Tgg	p.G221W	PTPN2_uc002krn.3_Missense_Mutation_p.G244W|PTPN2_uc002krl.3_Missense_Mutation_p.G221W|PTPN2_uc002krm.3_Missense_Mutation_p.G221W	NM_002828	NP_002819	P17706	PTN2_HUMAN	Homo sapiens protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 1, mRNA.	221	Substrate binding (By similarity).|Tyrosine-protein phosphatase.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway	endoplasmic reticulum|nucleoplasm	protein binding	p.G221G(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|prostate(1)|skin(3)	13		Lung NSC(161;8.94e-06)				CCAGAGCGCCCAATGCCTGCA	0.423000													4	115					0	0	1	0	0
C1orf112	55732	broad.mit.edu	37	1	169811624	169811624	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr1:169811624C>T	uc001ggp.3	+	18	2102	c.1792C>T	c.(1792-1794)Caa>Taa	p.Q598*	C1orf112_uc001ggj.3_Non-coding_Transcript|C1orf112_uc001ggq.3_Nonsense_Mutation_p.Q598*|C1orf112_uc009wvt.3_Nonsense_Mutation_p.Q275*|C1orf112_uc009wvu.1_Nonsense_Mutation_p.Q474*|C1orf112_uc001ggr.3_Nonsense_Mutation_p.Q463*|C1orf112_uc010plv.2_Nonsense_Mutation_p.Q540*	NM_018186	NP_060656	Q9NSG2	CA112_HUMAN	Homo sapiens chromosome 1 open reading frame 112 (C1orf112), mRNA.	598										breast(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|stomach(1)	34	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TACAGGAAAACAAACTGCAAT	0.368000													26	59					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875916	247875916	+	Silent	SNP	A	A	G			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr1:247875916A>G	uc001idj.1	-	0	142	c.142T>C	c.(142-144)Ttg>Ctg	p.L48L		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	Homo sapiens olfactory receptor, family 6, subfamily F, member 1 (OR6F1), mRNA.	48					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GTGCTCACCAACATCAAGATA	0.473000													9	113					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	65016141	65016141	+	Missense_Mutation	SNP	C	C	A			TCGA-DJ-A1QG-01A-11D-A14W-08	TCGA-DJ-A1QG-10A-01D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6423bb49-a2d1-4c64-9da3-21d387df5510	1de19931-dbc5-4464-9c0c-3cc08cbd4846	g.chr16:65016141C>A	uc002eoi.3	-	7	1497	c.1063G>T	c.(1063-1065)Gac>Tac	p.D355Y	CDH11_uc010cdn.3_Intron|CDH11_uc002eoj.3_Missense_Mutation_p.D355Y|CDH11_uc010vin.2_Missense_Mutation_p.D229Y|CDH11_uc002eok.1_Non-coding_Transcript	NM_001797	NP_001788	P55287	CAD11_HUMAN	Homo sapiens cadherin 11, type 2, OB-cadherin (osteoblast) (CDH11), mRNA.	355	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		AACTTCGGGTCGATGTGCACG	0.468000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			29	47					0	0	1	0	0