Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GNAL	2774	broad.mit.edu	37	18	11753670	11753670	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr18:11753670G>A	uc002kqc.2	+	2	920	c.493G>A	c.(493-495)Gat>Aat	p.D165N	GNAL_uc002kqd.2_Missense_Mutation_p.D88N|GNAL_uc010dkz.2_Missense_Mutation_p.D88N	NM_182978	NP_892023	P38405	GNAL_HUMAN	Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type (GNAL), transcript variant 1, mRNA.	88					activation of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception of smell|synaptic transmission	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|adenylate cyclase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(4)|ovary(1)	12						AAATGTTAAAGATGCTATCGT	0.318000													11	16					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179419249	179419249	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr2:179419249G>A	uc021vsy.1	-	280	81346	c.81121C>T	c.(81121-81123)Cga>Tga	p.R27041*	MIR548N_uc021vsx.1_Intron|LOC100506866_uc002umo.3_Intron|LOC100506866_uc002ump.2_Intron|TTN_uc021vsz.1_Nonsense_Mutation_p.R20736*|TTN_uc021vta.1_Nonsense_Mutation_p.R20669*|TTN_uc021vtb.1_Nonsense_Mutation_p.R20544*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	Homo sapiens titin (TTN), transcript variant N2-A, mRNA.	27968	Fibronectin type-III 97.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCACGGCTCGGACCCGGAAG	0.433000													9	21					0	0	1	0	0
ZNF679	168417	broad.mit.edu	37	7	63720697	63720697	+	Silent	SNP	A	A	G			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr7:63720697A>G	uc003tsx.3	+	2	407	c.138A>G	c.(136-138)ttA>ttG	p.L46L		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	Homo sapiens zinc finger protein 679 (ZNF679), mRNA.	46	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|skin(1)|stomach(1)	18						ATGTGATGTTAGAGAACTACA	0.378000													3	124					0	0	1	0	0
C19orf60	55049	broad.mit.edu	37	19	18701721	18701721	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr19:18701721C>T	uc002njv.4	+	3	628	c.511C>T	c.(511-513)Cgg>Tgg	p.R171W	C19orf60_uc002nju.2_Missense_Mutation_p.R183W|C19orf60_uc010ebs.3_Missense_Mutation_p.R149W	NM_001100418	NP_001093888	Q96EN9	CS060_HUMAN	Homo sapiens chromosome 19 open reading frame 60 (C19orf60), transcript variant 1, mRNA.	171							protein binding										GGACGCTGTACGGATGCAGCA	0.622000													3	11					0	0	1	0	0
D2HGDH	728294	broad.mit.edu	37	2	242680473	242680473	+	Silent	SNP	A	A	G			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr2:242680473A>G	uc002wce.1	+	2	491	c.318A>G	c.(316-318)ccA>ccG	p.P106P	D2HGDH_uc010zpc.1_Non-coding_Transcript|D2HGDH_uc010fzq.1_5'UTR|D2HGDH_uc002wcg.1_Non-coding_Transcript	NM_152783	NP_689996	Q8N465	D2HDH_HUMAN	Homo sapiens D-2-hydroxyglutarate dehydrogenase (D2HGDH), nuclear gene encoding mitochondrial protein, mRNA.	106	FAD-binding PCMH-type.				2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding			breast(1)|endometrium(3)|lung(10)|skin(1)|urinary_tract(1)	16		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		TGCTGAGGCCACGGACGTCGG	0.622000													4	26					0	0	1	0	0
FGD4	121512	broad.mit.edu	37	12	32778653	32778653	+	Missense_Mutation	SNP	A	A	T			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr12:32778653A>T	uc010ske.2	+	13	2121	c.2037A>T	c.(2035-2037)aaA>aaT	p.K679N	FGD4_uc001rlc.3_Missense_Mutation_p.K652N|FGD4_uc001rky.3_Missense_Mutation_p.K319N|FGD4_uc001rkz.3_Missense_Mutation_p.K567N|FGD4_uc001rla.3_Missense_Mutation_p.K223N|FGD4_uc001rlb.1_Non-coding_Transcript	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	Homo sapiens FYVE, RhoGEF and PH domain containing 4 (FGD4), mRNA.	567	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	Golgi apparatus|cytoskeleton|cytosol|filopodium|lamellipodium|ruffle	Rho guanyl-nucleotide exchange factor activity|metal ion binding|small GTPase binding	p.A679V(1)		breast(1)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	27	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					TGTGTATGAAATGTAAAGAAC	0.378000													8	49					0	0	1	0	0
UBXN6	80700	broad.mit.edu	37	19	4446104	4446104	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr19:4446104G>A	uc002man.2	-	9	1239	c.1142C>T	c.(1141-1143)gCc>gTc	p.A381V	UBXN6_uc002mam.2_Missense_Mutation_p.A328V	NM_025241	NP_079517	Q9BZV1	UBXN6_HUMAN	Homo sapiens UBX domain protein 6 (UBXN6), transcript variant 1, mRNA.	381	UBX.					microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	12						CCCTCCCGAGGCCAGCAGCTC	0.677000													8	36					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60837359	60837359	+	Missense_Mutation	SNP	A	A	C			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr17:60837359A>C	uc010dds.3	-	3	504	c.219T>G	c.(217-219)agT>agG	p.S73R	MARCH10_uc010ddr.3_Missense_Mutation_p.S73R|MARCH10_uc002jag.4_Missense_Mutation_p.S73R|MARCH10_uc002jah.2_Missense_Mutation_p.S73R	NM_152598	NP_689811	Q8NA82	MARHA_HUMAN	Homo sapiens membrane-associated ring finger (C3HC4) 10 (MARCH10), transcript variant 1, mRNA.	73							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						CATCCTCCTCACTAGAACTCT	0.423000													13	52					0	0	1	0	0
KDM4B	23030	broad.mit.edu	37	19	5111518	5111518	+	Silent	SNP	C	C	G			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr19:5111518C>G	uc010xil.1	+	10	1474	c.1248C>G	c.(1246-1248)ccC>ccG	p.P416P	KDM4B_uc002mbq.4_Intron|KDM4B_uc010xim.2_Intron|KDM4B_uc002mbr.4_Intron	NM_015015	NP_055830	O94953	KDM4B_HUMAN	Homo sapiens lysine (K)-specific demethylase 4B (KDM4B), mRNA.	414					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						AGGCAGGTCCCGGCCTAGGAG	0.642000													3	34					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35399705	35399705	+	Missense_Mutation	SNP	C	C	G			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr9:35399705C>G	uc003zwr.3	+	34	4360	c.4068C>G	c.(4066-4068)gaC>gaG	p.D1356E	UNC13B_uc003zwq.3_Missense_Mutation_p.D1356E	NM_006377	NP_006368	O14795	UN13B_HUMAN	Homo sapiens unc-13 homolog B (C. elegans) (UNC13B), mRNA.	1356	MHD2.				excretion|induction of apoptosis|intracellular signal transduction	Golgi apparatus|cell junction|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			CAGTCCTTGACCTCGCCCTGG	0.547000													11	159					0	0	1	0	0
TRPM4	54795	broad.mit.edu	37	19	49671841	49671841	+	Missense_Mutation	SNP	G	G	A			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr19:49671841G>A	uc002pmw.3	+	5	752	c.644G>A	c.(643-645)gGt>gAt	p.G215D	TRPM4_uc010emu.3_Missense_Mutation_p.G215D|TRPM4_uc010yak.2_5'UTR|TRPM4_uc002pmx.3_Missense_Mutation_p.G41D|TRPM4_uc010emv.3_Missense_Mutation_p.G100D|TRPM4_uc010yal.2_5'UTR	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	Homo sapiens transient receptor potential cation channel, subfamily M, member 4 (TRPM4), transcript variant 1, mRNA.	215					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	Golgi apparatus|endoplasmic reticulum|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding	p.R214R(1)		breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CGGTGGCGCGGTGACCCGGAG	0.657000													12	37					0	0	1	0	0
IFFO1	25900	broad.mit.edu	37	12	6659951	6659951	+	Silent	SNP	G	G	A			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr12:6659951G>A	uc010sfe.2	-	2	894	c.840C>T	c.(838-840)gcC>gcT	p.A280A	IFFO1_uc001qoy.3_Non-coding_Transcript|IFFO1_uc001qoz.2_5'Flank|IFFO1_uc001qpa.2_5'Flank|IFFO1_uc001qpb.1_5'Flank|IFFO1_uc001qpc.2_Silent_p.A280A|IFFO1_uc001qpf.2_Silent_p.A280A|IFFO1_uc001qpe.2_Non-coding_Transcript|IFFO1_uc001qpg.3_5'Flank	NM_001193457	NP_001180386	Q0D2I5	IFFO1_HUMAN	Homo sapiens intermediate filament family orphan 1 (IFFO1), transcript variant 5, mRNA.	280						intermediate filament				central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	20						CAGCCTCCTGGGCTTCCTGCA	0.582000													11	43					0	0	1	0	0
SH2D4A	63898	broad.mit.edu	37	8	19231046	19231046	+	Missense_Mutation	SNP	A	A	G			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr8:19231046A>G	uc003wzb.3	+	7	1381	c.923A>G	c.(922-924)cAg>cGg	p.Q308R	SH2D4A_uc011kym.2_Missense_Mutation_p.Q263R|SH2D4A_uc003wzc.3_Missense_Mutation_p.Q308R	NM_022071	NP_071354	Q9H788	SH24A_HUMAN	Homo sapiens SH2 domain containing 4A (SH2D4A), transcript variant 1, mRNA.	308						cytoplasm|nucleus	protein binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|stomach(1)	16				Colorectal(111;0.0732)		AACAGAAATCAGGGAGTGGTG	0.383000													3	30					0	0	1	0	0
CCRL1	51554	broad.mit.edu	37	3	132319255	132319255	+	Missense_Mutation	SNP	A	A	C			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr3:132319255A>C	uc003eow.3	+	1	97	c.14A>C	c.(13-15)cAg>cCg	p.Q5P	NPHP3_uc003eov.4_Intron|NPHP3_uc011blr.1_Intron|CCRL1_uc003eox.3_Missense_Mutation_p.Q5P	NM_016557	NP_848540	Q9NPB9	CCRL1_HUMAN	Homo sapiens chemokine (C-C motif) receptor-like 1 (CCRL1), transcript variant 2, mRNA.	5					chemotaxis|immune response	integral to plasma membrane	C-C chemokine receptor activity			breast(1)|endometrium(4)|large_intestine(6)|lung(6)	17						GCTTTGGAACAGAACCAGTCA	0.338000													5	7					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25890631	25890631	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr8:25890631T>C	uc003xes.2	-	5	786	c.521A>G	c.(520-522)gAg>gGg	p.E174G	DOCK5_uc003xek.3_Intron|EBF2_uc003xet.2_Missense_Mutation_p.E174G	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	Homo sapiens early B-cell factor 2 (EBF2), mRNA.	174					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		CGATGGAGTCTCATTTCGGTT	0.393000													3	79					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157504590	157504590	+	Missense_Mutation	SNP	C	C	A			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr1:157504590C>A	uc009wsm.3	-	7	1653	c.1495G>T	c.(1495-1497)Ggt>Tgt	p.G499C	FCRL5_uc001fqu.3_Missense_Mutation_p.G499C|FCRL5_uc010phv.1_Missense_Mutation_p.G499C|FCRL5_uc010phw.1_Missense_Mutation_p.G414C|FCRL5_uc001fqv.1_Missense_Mutation_p.G499C|FCRL5_uc010phx.2_Missense_Mutation_p.G250C	NM_001195388	NP_001182317	Q96RD9	FCRL5_HUMAN	Homo sapiens Fc receptor-like 5 (FCRL5), transcript variant 2, mRNA.	499	Ig-like C2-type 5.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TGTGGGGAACCTCTCTGGACT	0.527000													12	42					0	0	1	0	0
GPR151	134391	broad.mit.edu	37	5	145895152	145895152	+	Missense_Mutation	SNP	A	A	T			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr5:145895152A>T	uc003lod.1	-	0	525	c.525T>A	c.(523-525)ttT>ttA	p.F175L		NM_194251	NP_919227	Q8TDV0	GP151_HUMAN	Homo sapiens G protein-coupled receptor 151 (GPR151), mRNA.	175						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(2)	14			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGATGGTGCTAAAGAACCATT	0.522000													12	39					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				10	50					0	0	1	0	0
LYPD6B	130576	broad.mit.edu	37	2	150017336	150017336	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr2:150017336delT	uc002twv.1	+	2	465	c.64delT	c.(64-66)ttcfs	p.F22fs	LYPD6B_uc002tww.1_Intron|LYPD6B_uc002twx.1_Intron	NM_177964	NP_808879	Q8NI32	LPD6B_HUMAN	Homo sapiens LY6/PLAUR domain containing 6B (LYPD6B), mRNA.	0						anchored to membrane|plasma membrane				endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11						GACAACCACATTCTCCTTCTC	0.468													2	4	---	---	---	---					
NEFM	4741	broad.mit.edu	37	8	24774945	24774945	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DJ-A2Q3-01A-11D-A18F-08	TCGA-DJ-A2Q3-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ddec4477-986f-45fd-9d67-3c0b60db69ce	75811819-5756-4255-9e6c-397b11987a25	g.chr8:24774945delA	uc003xed.4	+	2	1610	c.1577delA	c.(1576-1578)gaafs	p.E526fs	NEFM_uc011lac.1_Frame_Shift_Del_p.E526fs|NEFM_uc010lue.3_Frame_Shift_Del_p.E150fs	NM_005382	NP_005373	P07197	NFM_HUMAN	Homo sapiens neurofilament, medium polypeptide (NEFM), transcript variant 1, mRNA.	526	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		gaggaaggggaaaaggaggaa	0.488													2	4	---	---	---	---