Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
WASH2P	375260	broad.mit.edu	37	2	114355097	114355097	+	Silent	SNP	C	C	T			TCGA-DJ-A3VB-01A-11D-A23M-08	TCGA-DJ-A3VB-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8ed773-385b-403c-84c7-b844e09dc4c1	0332cc08-f29e-466a-a43f-a653c565ab06	g.chr2:114355097C>T	uc002tkh.3	+	3	532	c.474C>T	c.(472-474)tcC>tcT	p.S158S	WASH2P_uc002tka.3_Non-coding_Transcript|WASH2P_uc002tkd.3_Non-coding_Transcript|WASH2P_uc010fkz.1_Non-coding_Transcript|WASH2P_uc002tkf.2_Non-coding_Transcript					Homo sapiens WAS protein family homolog 2 pseudogene (WASH2P), non-coding RNA.																		TCGACCCCTCCGGTGGCCGGG	0.647000													7	15					0	0	1	0	0
GRK1	6011	broad.mit.edu	37	13	114324127	114324127	+	Silent	SNP	C	C	T			TCGA-DJ-A3VB-01A-11D-A23M-08	TCGA-DJ-A3VB-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8ed773-385b-403c-84c7-b844e09dc4c1	0332cc08-f29e-466a-a43f-a653c565ab06	g.chr13:114324127C>T	uc010tkf.2	+	1	930	c.825C>T	c.(823-825)atC>atT	p.I275I		NM_002929	NP_002920	Q15835	RK_HUMAN	Homo sapiens G protein-coupled receptor kinase 1 (GRK1), mRNA.	275	Protein kinase.				regulation of G-protein coupled receptor protein signaling pathway|rhodopsin mediated phototransduction|rhodopsin mediated signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|rhodopsin kinase activity|signal transducer activity			ovary(2)	2	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.00696)|all_epithelial(44;0.00347)|all_lung(25;0.0221)|Breast(118;0.0411)|Lung NSC(25;0.0839)	all cancers(43;0.234)			GAGGTGACATCAGGTAAGGGC	0.597000													7	139					0	0	1	0	0
SLC40A1	30061	broad.mit.edu	37	2	190439928	190439928	+	Missense_Mutation	SNP	G	G	C	rs28939076		TCGA-DJ-A3VB-01A-11D-A23M-08	TCGA-DJ-A3VB-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8ed773-385b-403c-84c7-b844e09dc4c1	0332cc08-f29e-466a-a43f-a653c565ab06	g.chr2:190439928G>C	uc002uqp.4	-	2	581	c.230C>G	c.(229-231)gCc>gGc	p.A77G	SLC40A1_uc002uqq.2_Missense_Mutation_p.A77G	NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	Homo sapiens solute carrier family 40 (iron-regulated transporter), member 1 (SLC40A1), mRNA.	77			A -> D (in HFE4).		anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			ACCGATGATGGCTCCCAGGAC	0.493000													154	304					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77763175	77763175	+	Missense_Mutation	SNP	T	T	C			TCGA-DJ-A3VB-01A-11D-A23M-08	TCGA-DJ-A3VB-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8ed773-385b-403c-84c7-b844e09dc4c1	0332cc08-f29e-466a-a43f-a653c565ab06	g.chr13:77763175T>C	uc021rks.1	-	29	4429	c.4162A>G	c.(4162-4164)Acc>Gcc	p.T1388A	MYCBP2_uc010aev.3_Missense_Mutation_p.T754A	NM_015057	NP_055872	O75592	MYCB2_HUMAN	Homo sapiens MYC binding protein 2 (MYCBP2), mRNA.	1350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CCATCACTGGTTGGAAGTCTA	0.343000													29	42					0	0	1	0	0
MCM4	4173	broad.mit.edu	37	8	48883923	48883923	+	Missense_Mutation	SNP	A	A	T			TCGA-DJ-A3VB-01A-11D-A23M-08	TCGA-DJ-A3VB-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8ed773-385b-403c-84c7-b844e09dc4c1	0332cc08-f29e-466a-a43f-a653c565ab06	g.chr8:48883923A>T	uc003xqk.2	+	12	2649	c.1823A>T	c.(1822-1824)aAt>aTt	p.N608I	MCM4_uc003xql.2_Missense_Mutation_p.N608I|MCM4_uc011ldi.2_Missense_Mutation_p.N595I	NM_182746	NP_877423	P33991	MCM4_HUMAN	Homo sapiens minichromosome maintenance complex component 4 (MCM4), transcript variant 2, mRNA.	608	MCM.				DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|cell cycle checkpoint	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(7)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	44		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				TGTCAGCTCAATGCGCGCACC	0.498000													18	69					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DJ-A3VB-01A-11D-A23M-08	TCGA-DJ-A3VB-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8ed773-385b-403c-84c7-b844e09dc4c1	0332cc08-f29e-466a-a43f-a653c565ab06	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				29	48					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119916995	119916995	+	Silent	SNP	C	C	T			TCGA-DJ-A3VB-01A-11D-A23M-08	TCGA-DJ-A3VB-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8ed773-385b-403c-84c7-b844e09dc4c1	0332cc08-f29e-466a-a43f-a653c565ab06	g.chr12:119916995C>T	uc001txe.3	+	3	903	c.438C>T	c.(436-438)acC>acT	p.T146T	AF086288_uc001txf.3_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	Homo sapiens coiled-coil domain containing 60 (CCDC60), mRNA.	146										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		CCTCGCTAACCGAGGCTCACG	0.478000													32	43					0	0	1	0	0
FPGT-TNNI3K	100526835	broad.mit.edu	37	1	74715180	74715180	+	Missense_Mutation	SNP	C	C	T	rs79045456		TCGA-DJ-A3VB-01A-11D-A23M-08	TCGA-DJ-A3VB-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8ed773-385b-403c-84c7-b844e09dc4c1	0332cc08-f29e-466a-a43f-a653c565ab06	g.chr1:74715180C>T	uc001dge.2	+	4	557	c.490C>T	c.(490-492)Cgc>Tgc	p.R164C	FPGT-TNNI3K_uc001dgc.2_Missense_Mutation_p.R164C|FPGT-TNNI3K_uc001dgd.3_Missense_Mutation_p.R164C|FPGT-TNNI3K_uc001dgf.2_Missense_Mutation_p.R63C	NM_001112808	NP_001106279	Q59H18	TNI3K_HUMAN	Homo sapiens FPGT-TNNI3K readthrough (FPGT-TNNI3K), transcript variant 1, mRNA.	63						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding										TTTAAATTACCGCACTGAAAA	0.333000													7	50					0	0	1	0	0
LRPAP1	4043	broad.mit.edu	37	4	3516526	3516526	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A3VB-01A-11D-A23M-08	TCGA-DJ-A3VB-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8ed773-385b-403c-84c7-b844e09dc4c1	0332cc08-f29e-466a-a43f-a653c565ab06	g.chr4:3516526C>T	uc003ghh.4	-	6	1049	c.964G>A	c.(964-966)Gag>Aag	p.E322K		NM_002337	NP_002328	P30533	AMRP_HUMAN	Homo sapiens low density lipoprotein receptor-related protein associated protein 1 (LRPAP1), mRNA.	322	LDL receptor binding (Potential).				negative regulation of protein binding|negative regulation of very-low-density lipoprotein particle clearance|protein folding|vesicle-mediated transport	cell surface|integral to membrane|plasma membrane	asialoglycoprotein receptor activity|heparin binding|low-density lipoprotein particle receptor binding|receptor antagonist activity|unfolded protein binding|very-low-density lipoprotein particle receptor binding			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	14				UCEC - Uterine corpus endometrioid carcinoma (64;0.165)		GCGTGCTTCTCGCGGCTGCGG	0.662000													42	87					0	0	1	0	0
ZNF630	57232	broad.mit.edu	37	X	47918136	47918136	+	Silent	SNP	A	A	G			TCGA-DJ-A3VB-01A-11D-A23M-08	TCGA-DJ-A3VB-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8ed773-385b-403c-84c7-b844e09dc4c1	0332cc08-f29e-466a-a43f-a653c565ab06	g.chrX:47918136A>G	uc004div.4	-	4	1947	c.1695T>C	c.(1693-1695)caT>caC	p.H565H	ZNF630_uc010nhz.1_Intron|ZNF630_uc022bvr.1_Silent_p.H551H|ZNF630_uc022bvs.1_Silent_p.H565H	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	Homo sapiens zinc finger protein 630 (ZNF630), transcript variant 1, mRNA.	565					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(6)|lung(11)|ovary(1)	19						TCTCTCCAGTATGACCTCTCT	0.453000													4	15					0	0	1	0	0
EXOC3L2	90332	broad.mit.edu	37	19	45721473	45721473	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A3VB-01A-11D-A23M-08	TCGA-DJ-A3VB-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8ed773-385b-403c-84c7-b844e09dc4c1	0332cc08-f29e-466a-a43f-a653c565ab06	g.chr19:45721473C>T	uc002pay.1	-	6	686	c.645G>A	c.(643-645)atG>atA	p.M215I		NM_138568	NP_612635	Q2M3D2	EX3L2_HUMAN	Homo sapiens exocyst complex component 3-like 2 (EXOC3L2), mRNA.	215										endometrium(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		GCTCGTCCTGCATTCTGCGCA	0.667000													5	8					0	0	1	0	0
GPR139	124274	broad.mit.edu	37	16	20043241	20043241	+	Missense_Mutation	SNP	C	C	T			TCGA-DJ-A3VB-01A-11D-A23M-08	TCGA-DJ-A3VB-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db8ed773-385b-403c-84c7-b844e09dc4c1	0332cc08-f29e-466a-a43f-a653c565ab06	g.chr16:20043241C>T	uc002dgu.1	-	1	1040	c.878G>A	c.(877-879)cGc>cAc	p.R293H	GPR139_uc010vaw.1_Missense_Mutation_p.R200H	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	Homo sapiens G protein-coupled receptor 139 (GPR139), mRNA.	293						integral to membrane|plasma membrane		p.R293R(1)		autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						TGCCATGGTGCGGAACCGCTT	0.512000													75	141					0	0	1	0	0