Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RC3H2	54542	broad.mit.edu	37	9	125639844	125639844	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A22I-01A-11D-A17V-08	TCGA-EM-A22I-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e0636a7b-490a-44e0-8512-062c989896ce	db5dcc71-4c5c-4843-9048-3c25cf68feb4	g.chr9:125639844A>G	uc010mwc.1	-	8	1472	c.1231T>C	c.(1231-1233)Tac>Cac	p.Y411H	RC3H2_uc004bnc.2_Non-coding_Transcript|RC3H2_uc004bnd.1_Missense_Mutation_p.Y411H|RC3H2_uc004bne.4_Missense_Mutation_p.Y411H|RC3H2_uc011lzf.2_Missense_Mutation_p.Y148H|RC3H2_uc011lzg.2_Missense_Mutation_p.Y411H	NM_001100588	NP_001094058	Q9HBD1	RC3H2_HUMAN	Homo sapiens ring finger and CCCH-type domains 2 (RC3H2), transcript variant 1, mRNA.	411						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding	p.Y411*(1)		breast(3)|central_nervous_system(1)|endometrium(6)|large_intestine(4)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						CTAGTCTTGTATTTGCTGTTT	0.418000													7	176					0	0	1	0	0
CACNB1	782	broad.mit.edu	37	17	37333738	37333738	+	Silent	SNP	C	C	T			TCGA-EM-A22I-01A-11D-A17V-08	TCGA-EM-A22I-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e0636a7b-490a-44e0-8512-062c989896ce	db5dcc71-4c5c-4843-9048-3c25cf68feb4	g.chr17:37333738C>T	uc002hrm.2	-	12	1405	c.1197G>A	c.(1195-1197)gaG>gaA	p.E399E	CACNB1_uc002hrl.1_Silent_p.E171E|CACNB1_uc002hrn.3_Silent_p.E399E|CACNB1_uc002hro.3_Silent_p.E444E	NM_000723	NP_000714	Q02641	CACB1_HUMAN	Homo sapiens calcium channel, voltage-dependent, beta 1 subunit (CACNB1), transcript variant 1, mRNA.	399					axon guidance	voltage-gated calcium channel complex				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	16					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	CCGCCAGATGCTCGCAGGCAT	0.607000													16	27					0	0	1	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47621731	47621731	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A22I-01A-11D-A17V-08	TCGA-EM-A22I-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e0636a7b-490a-44e0-8512-062c989896ce	db5dcc71-4c5c-4843-9048-3c25cf68feb4	g.chr20:47621731C>T	uc002xtx.4	+	25	3709	c.3557C>T	c.(3556-3558)cCc>cTc	p.P1186L	ARFGEF2_uc010zyf.2_Missense_Mutation_p.P479L	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	Homo sapiens ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) (ARFGEF2), mRNA.	1186					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	Golgi membrane|cytosol	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TTTCTGAGGCCCTTTGAGCAT	0.448000													12	91					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72831798	72831798	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A22I-01A-11D-A17V-08	TCGA-EM-A22I-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e0636a7b-490a-44e0-8512-062c989896ce	db5dcc71-4c5c-4843-9048-3c25cf68feb4	g.chr16:72831798G>C	uc002fck.3	-	8	5456	c.4783C>G	c.(4783-4785)Cct>Gct	p.P1595A	ZFHX3_uc002fcl.3_Missense_Mutation_p.P681A	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	Homo sapiens zinc finger homeobox 3 (ZFHX3), transcript variant A, mRNA.	1595					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.P1595L(1)		NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CACTTAAAAGGTTTGTTGTCT	0.488000													21	48					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47944122	47944122	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A22I-01A-11D-A17V-08	TCGA-EM-A22I-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e0636a7b-490a-44e0-8512-062c989896ce	db5dcc71-4c5c-4843-9048-3c25cf68feb4	g.chr7:47944122C>T	uc003tny.2	-	11	1818	c.1784G>A	c.(1783-1785)cGg>cAg	p.R595Q		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	Homo sapiens polycystic kidney disease 1 like 1 (PKD1L1), mRNA.	595	PKD 2.				cell-cell adhesion	integral to membrane		p.R595W(1)	BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						GGACGTGAGCCGATTGGCCAC	0.537000													15	39					0	0	1	0	0
RBM11	54033	broad.mit.edu	37	21	15599326	15599326	+	Silent	SNP	A	A	G			TCGA-EM-A22I-01A-11D-A17V-08	TCGA-EM-A22I-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e0636a7b-490a-44e0-8512-062c989896ce	db5dcc71-4c5c-4843-9048-3c25cf68feb4	g.chr21:15599326A>G	uc002yjo.4	+	4	600	c.558A>G	c.(556-558)tcA>tcG	p.S186S	RBM11_uc002yjn.4_Silent_p.S72S|RBM11_uc002yjp.4_Silent_p.S72S	NM_144770	NP_658983	P57052	RBM11_HUMAN	Homo sapiens RNA binding motif protein 11 (RBM11), mRNA.	186							RNA binding|nucleotide binding			endometrium(3)|kidney(3)|lung(7)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		GACCCAGCTCATATAAATGGA	0.453000													7	199					0	0	1	0	0
C10orf99	387695	broad.mit.edu	37	10	85944480	85944480	+	Silent	SNP	G	G	A			TCGA-EM-A22I-01A-11D-A17V-08	TCGA-EM-A22I-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e0636a7b-490a-44e0-8512-062c989896ce	db5dcc71-4c5c-4843-9048-3c25cf68feb4	g.chr10:85944480G>A	uc001kcu.3	+	2	258	c.204G>A	c.(202-204)gaG>gaA	p.E68E		NM_207373	NP_997256	Q6UWK7	CJ099_HUMAN	Homo sapiens chromosome 10 open reading frame 99 (C10orf99), mRNA.	68						extracellular region		p.P67>?(1)		endometrium(1)|lung(1)|pancreas(1)|prostate(1)	4						TTGAGCCAGAGCCCCGCCTTT	0.577000													5	60					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-EM-A22I-01A-11D-A17V-08	TCGA-EM-A22I-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e0636a7b-490a-44e0-8512-062c989896ce	db5dcc71-4c5c-4843-9048-3c25cf68feb4	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				9	25					0	0	1	0	0
HCFC1	3054	broad.mit.edu	37	X	153228845	153228845	+	Silent	SNP	G	G	A			TCGA-EM-A22I-01A-11D-A17V-08	TCGA-EM-A22I-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e0636a7b-490a-44e0-8512-062c989896ce	db5dcc71-4c5c-4843-9048-3c25cf68feb4	g.chrX:153228845G>A	uc004fjp.3	-	3	1071	c.543C>T	c.(541-543)ggC>ggT	p.G181G		NM_005334	NP_005325	P51610	HCFC1_HUMAN	Homo sapiens host cell factor C1 (VP16-accessory protein) (HCFC1), mRNA.	181					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex|MLL5-L complex|Set1C/COMPASS complex|mitochondrion	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCACTCCAGAGCCTGGCCGTA	0.527000													24	44					0	0	1	0	0
LRRCC1	85444	broad.mit.edu	37	8	86050374	86050374	+	Missense_Mutation	SNP	T	T	A			TCGA-EM-A22I-01A-11D-A17V-08	TCGA-EM-A22I-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e0636a7b-490a-44e0-8512-062c989896ce	db5dcc71-4c5c-4843-9048-3c25cf68feb4	g.chr8:86050374T>A	uc003ycw.3	+	15	2806	c.2598T>A	c.(2596-2598)gaT>gaA	p.D866E	LRRCC1_uc022awx.1_Missense_Mutation_p.D773E|LRRCC1_uc010maa.2_Missense_Mutation_p.D567E|LRRCC1_uc003ycy.3_Missense_Mutation_p.D846E	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	Homo sapiens leucine rich repeat and coiled-coil domain containing 1 (LRRCC1), mRNA.	866					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						CACAACTGGATGAGGTACTTG	0.318000													11	12					0	0	1	0	0
ANAPC2	29882	broad.mit.edu	37	9	140074764	140074765	+	Missense_Mutation	DNP	GC	GC	AT			TCGA-EM-A22I-01A-11D-A17V-08	TCGA-EM-A22I-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e0636a7b-490a-44e0-8512-062c989896ce	db5dcc71-4c5c-4843-9048-3c25cf68feb4	g.chr9:140074764_140074765GC>AT	uc004clr.1	-	9	1831_1832	c.1758_1759GC>AT	c.(1756-1761)cagcca>caATca	p.P587S	ANAPC2_uc004clq.1_Missense_Mutation_p.P443S	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	Homo sapiens anaphase promoting complex subunit 2 (ANAPC2), mRNA.	587					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		CCGAACGGTGGCTGCTCCTCTG	0.644000													4	77					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145113595	145113595	+	Splice_Site	SNP	C	C	T			TCGA-EM-A22I-01A-11D-A17V-08	TCGA-EM-A22I-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e0636a7b-490a-44e0-8512-062c989896ce	db5dcc71-4c5c-4843-9048-3c25cf68feb4	g.chr8:145113595C>T	uc003zar.3	-	6	670	c.588_splice	c.e6-1	p.T196_splice	OPLAH_uc003zat.1_Splice_Site	NM_017570	NP_060040	O14841	OPLA_HUMAN	Homo sapiens 5-oxoprolinase (ATP-hydrolysing) (OPLAH), mRNA.	196							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CTGGGCCCACCTATGACAAAA	0.657000													4	21					0	0	1	0	0