Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PCM1	5108	broad.mit.edu	37	8	17830011	17830011	+	Missense_Mutation	SNP	T	T	G			TCGA-EM-A2CK-01A-11D-A17V-08	TCGA-EM-A2CK-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83e36900-8a9a-4356-94d0-ca431a535382	68d9273f-e401-4444-a139-1cb3ae1f89f5	g.chr8:17830011T>G	uc022asj.1	+	21	3897	c.3875T>G	c.(3874-3876)tTt>tGt	p.F1292C	PCM1_uc003wyi.4_Missense_Mutation_p.F1253C|PCM1_uc011kyh.2_Missense_Mutation_p.F1253C|PCM1_uc003wyj.4_Missense_Mutation_p.F1254C|PCM1_uc011kyi.2_Missense_Mutation_p.F115C|PCM1_uc011kyj.2_5'UTR|PCM1_uc003wyk.4_5'UTR	NM_006197	NP_006188	Q15154	PCM1_HUMAN	Homo sapiens pericentriolar material 1 (PCM1), mRNA.	1253	Interaction with HAP1.				G2/M transition of mitotic cell cycle|centrosome organization|cilium assembly|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	breast(4)|endometrium(8)|kidney(5)|large_intestine(16)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	48				Colorectal(111;0.0789)		AGACGCCAGTTTGATGAAGAA	0.393000			T	"""RET, JAK2"""	"""papillary thyroid, CML, MPD"""								6	94					0	0	1	0	0
CYP11B1	1584	broad.mit.edu	37	8	143957756	143957756	+	Missense_Mutation	SNP	C	C	G			TCGA-EM-A2CK-01A-11D-A17V-08	TCGA-EM-A2CK-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83e36900-8a9a-4356-94d0-ca431a535382	68d9273f-e401-4444-a139-1cb3ae1f89f5	g.chr8:143957756C>G	uc010mey.3	-	6	1075	c.1068G>C	c.(1066-1068)caG>caC	p.Q356H	CYP11B1_uc010mex.3_5'Flank|CYP11B1_uc003yxh.3_5'UTR|CYP11B1_uc003yxi.3_Missense_Mutation_p.Q285H|CYP11B1_uc003yxj.3_Missense_Mutation_p.Q285H	NM_000497	NP_000488	P15538	C11B1_HUMAN	Homo sapiens cytochrome P450, family 11, subfamily B, polypeptide 1 (CYP11B1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	285					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	TGCTGGTGTACTGTTGAGGGC	0.582000									Familial Hyperaldosteronism type I				4	43					0	0	1	0	0
PPP1R1C	151242	broad.mit.edu	37	2	182852550	182852550	+	Silent	SNP	C	C	A			TCGA-EM-A2CK-01A-11D-A17V-08	TCGA-EM-A2CK-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83e36900-8a9a-4356-94d0-ca431a535382	68d9273f-e401-4444-a139-1cb3ae1f89f5	g.chr2:182852550C>A	uc010frm.1	+	1	374	c.87C>A	c.(85-87)ggC>ggA	p.G29G	PPP1R1C_uc002uoo.3_Intron|PPP1R1C_uc002uop.1_Intron|PPP1R1C_uc010frn.1_Intron	NM_001080545	NP_001074014	Q8WVI7	PPR1C_HUMAN	Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 1C (PPP1R1C), mRNA.	27					signal transduction	cytoplasm	protein phosphatase inhibitor activity			NS(1)|breast(1)|endometrium(2)|large_intestine(2)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0628)			ATTAGCTGGGCTTTTGTCGTT	0.443000													53	73					0	0	1	0	0
LRRC8A	56262	broad.mit.edu	37	9	131670993	131670993	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A2CK-01A-11D-A17V-08	TCGA-EM-A2CK-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83e36900-8a9a-4356-94d0-ca431a535382	68d9273f-e401-4444-a139-1cb3ae1f89f5	g.chr9:131670993C>T	uc004bwl.4	+	2	1804	c.1550C>T	c.(1549-1551)aCa>aTa	p.T517I	LRRC8A_uc010myp.3_Missense_Mutation_p.T517I|LRRC8A_uc010myq.3_Missense_Mutation_p.T517I	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	Homo sapiens leucine rich repeat containing 8 family, member A (LRRC8A), transcript variant 2, mRNA.	517					pre-B cell differentiation	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(3)	28						AGCCTGAAGACACTGGAGGAG	0.622000													15	41					0	0	1	0	0
HRAS	3265	broad.mit.edu	37	11	533874	533874	+	Missense_Mutation	SNP	T	T	C	rs121913233		TCGA-EM-A2CK-01A-11D-A17V-08	TCGA-EM-A2CK-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83e36900-8a9a-4356-94d0-ca431a535382	68d9273f-e401-4444-a139-1cb3ae1f89f5	g.chr11:533874T>C	uc001lpv.3	-	2	370	c.182A>G	c.(181-183)cAg>cGg	p.Q61R	HRAS_uc010qvw.2_Missense_Mutation_p.Q61R|HRAS_uc010qvx.2_Missense_Mutation_p.Q61R|HRAS_uc010qvy.2_Non-coding_Transcript	NM_005343	NP_005334	P01112	RASH_HUMAN	Homo sapiens v-Ha-ras Harvey rat sarcoma viral oncogene homolog (HRAS), transcript variant 1, mRNA.	61			Q -> K (in follicular thyroid carcinoma samples; somatic mutation; increases transformation of cultured cell lines; dbSNP:rs28933406).|Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).		Ras protein signal transduction|activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|synaptic transmission	Golgi membrane|cytosol|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(265)|p.Q61L(230)|p.Q61K(59)|p.Q61H(20)|p.Q61P(6)|p.Q61?(1)|p.Q61Q(1)|p.Q61E(1)		adrenal_gland(1)|bone(3)|breast(7)|cervix(23)|endometrium(4)|haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(2)|liver(1)|lung(16)|oesophagus(2)|penis(2)|pituitary(10)|prostate(31)|salivary_gland(24)|skin(184)|soft_tissue(38)|stomach(14)|testis(5)|thymus(1)|thyroid(173)|upper_aerodigestive_tract(122)|urinary_tract(225)	901		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GTACTCCTCCTGGCCGGCGGT	0.597000	Q61L(KNS62_LUNG)|Q61L(KYSE30_OESOPHAGUS)|Q61L(NCIH1915_LUNG)	6	Mis		"""infrequent sarcomas, rare other types"""	"""rhadomyosarcoma, ganglioneuroblastoma, bladder"""			Costello syndrome	HNSCC(11;0.0054)			52	72					0	0	1	0	0
FHL3	2275	broad.mit.edu	37	1	38463709	38463709	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A2CK-01A-11D-A17V-08	TCGA-EM-A2CK-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83e36900-8a9a-4356-94d0-ca431a535382	68d9273f-e401-4444-a139-1cb3ae1f89f5	g.chr1:38463709G>C	uc001cck.3	-	3	606	c.427C>G	c.(427-429)Ccc>Gcc	p.P143A	FHL3_uc001ccm.3_Missense_Mutation_p.P35A|FHL3_uc009vvl.2_Missense_Mutation_p.P143A	NM_004468	NP_004459	Q13643	FHL3_HUMAN	Homo sapiens four and a half LIM domains 3 (FHL3), transcript variant 1, mRNA.	143	LIM zinc-binding 2.				muscle organ development		zinc ion binding	p.P143S(2)		endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	5	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CCCTTGTCGGGCACAAAAGAA	0.622000													47	81					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56690784	56690784	+	Nonsense_Mutation	SNP	G	G	A	rs141801212	byFrequency	TCGA-EM-A2CK-01A-11D-A17V-08	TCGA-EM-A2CK-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83e36900-8a9a-4356-94d0-ca431a535382	68d9273f-e401-4444-a139-1cb3ae1f89f5	g.chr17:56690784G>A	uc010dcz.2	-	8	1139	c.1021C>T	c.(1021-1023)Cga>Tga	p.R341*	TEX14_uc002iwr.2_Nonsense_Mutation_p.R335*|TEX14_uc002iws.2_Nonsense_Mutation_p.R335*|TEX14_uc010dda.2_Nonsense_Mutation_p.R115*	NM_001201457	NP_001188386	Q8IWB6	TEX14_HUMAN	Homo sapiens testis expressed 14 (TEX14), transcript variant 3, mRNA.	341	Protein kinase.					cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CAGTTTACTCGTTCATGAAGG	0.517000													41	75					0	0	1	0	0
UBOX5	22888	broad.mit.edu	37	20	3090865	3090865	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A2CK-01A-11D-A17V-08	TCGA-EM-A2CK-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83e36900-8a9a-4356-94d0-ca431a535382	68d9273f-e401-4444-a139-1cb3ae1f89f5	g.chr20:3090865C>T	uc002whw.3	-	4	1683	c.1513G>A	c.(1513-1515)Ggc>Agc	p.G505S	LOC100134015_uc002whv.1_Intron|UBOX5_uc002whx.3_Missense_Mutation_p.G451S|UBOX5_uc002why.1_Missense_Mutation_p.R503Q	NM_014948	NP_055763	O94941	RNF37_HUMAN	Homo sapiens U-box domain containing 5 (UBOX5), transcript variant 1, mRNA.	505						nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	20						AGGAGGTGGCCGCAGGGCAGC	0.627000													5	154					0	0	1	0	0
LRFN3	79414	broad.mit.edu	37	19	36430922	36430922	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A2CK-01A-11D-A17V-08	TCGA-EM-A2CK-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83e36900-8a9a-4356-94d0-ca431a535382	68d9273f-e401-4444-a139-1cb3ae1f89f5	g.chr19:36430922G>A	uc002oco.3	+	1	1047	c.595G>A	c.(595-597)Gct>Act	p.A199T		NM_024509	NP_078785	Q9BTN0	LRFN3_HUMAN	Homo sapiens leucine rich repeat and fibronectin type III domain containing 3 (LRFN3), mRNA.	199					cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane				cervix(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	12	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GCCCGCCGGCGCTTTTTCCCG	0.677000													74	156					0	0	1	0	0
MOG	4340	broad.mit.edu	37	6	29639214	29639214	+	Missense_Mutation	SNP	C	C	G			TCGA-EM-A2CK-01A-11D-A17V-08	TCGA-EM-A2CK-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83e36900-8a9a-4356-94d0-ca431a535382	68d9273f-e401-4444-a139-1cb3ae1f89f5	g.chr6:29639214C>G	uc003nne.3	+	7	975	c.746C>G	c.(745-747)gCc>gGc	p.A249G	MOG_uc003nna.3_3'UTR|MOG_uc011dlt.2_3'UTR|MOG_uc011dlv.2_3'UTR|MOG_uc011dlu.2_3'UTR|MOG_uc003nnf.3_3'UTR|MOG_uc003nng.3_Missense_Mutation_p.A226G|MOG_uc003nni.3_3'UTR|MOG_uc003nnh.3_Missense_Mutation_p.A210G|MOG_uc003nnj.3_3'UTR|MOG_uc003nnk.3_Missense_Mutation_p.A203G	NM_002433	NP_002424	Q16653	MOG_HUMAN	Homo sapiens myelin oligodendrocyte glycoprotein (MOG), transcript variant beta1, mRNA.	0					cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|skin(2)	19						CACCTGGAAGCCCTCTCTGGC	0.488000													40	66					0	0	1	0	0
CHST8	64377	broad.mit.edu	37	19	34262953	34262953	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A2CK-01A-11D-A17V-08	TCGA-EM-A2CK-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	83e36900-8a9a-4356-94d0-ca431a535382	68d9273f-e401-4444-a139-1cb3ae1f89f5	g.chr19:34262953G>A	uc002nus.4	+	4	765	c.260G>A	c.(259-261)cGc>cAc	p.R87H	CHST8_uc002nut.4_Missense_Mutation_p.R87H|CHST8_uc002nuu.3_Missense_Mutation_p.R87H	NM_001127895	NP_071912	Q9H2A9	CHST8_HUMAN	Homo sapiens carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 (CHST8), transcript variant 2, mRNA.	87					carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(5)	27	Esophageal squamous(110;0.162)					CCGAGGGGCCGCAACCTGCCA	0.667000													14	30					0	0	1	0	0